@article{680,
  abstract     = {In order to respond reliably to specific features of their environment, sensory neurons need to integrate multiple incoming noisy signals. Crucially, they also need to compete for the interpretation of those signals with other neurons representing similar features. The form that this competition should take depends critically on the noise corrupting these signals. In this study we show that for the type of noise commonly observed in sensory systems, whose variance scales with the mean signal, sensory neurons should selectively divide their input signals by their predictions, suppressing ambiguous cues while amplifying others. Any change in the stimulus context alters which inputs are suppressed, leading to a deep dynamic reshaping of neural receptive fields going far beyond simple surround suppression. Paradoxically, these highly variable receptive fields go alongside and are in fact required for an invariant representation of external sensory features. In addition to offering a normative account of context-dependent changes in sensory responses, perceptual inference in the presence of signal-dependent noise accounts for ubiquitous features of sensory neurons such as divisive normalization, gain control and contrast dependent temporal dynamics.},
  author       = {Chalk, Matthew J and Masset, Paul and Gutkin, Boris and Denève, Sophie},
  issn         = {1553-734X},
  journal      = {PLoS Computational Biology},
  number       = {6},
  publisher    = {Public Library of Science},
  title        = {{Sensory noise predicts divisive reshaping of receptive fields}},
  doi          = {10.1371/journal.pcbi.1005582},
  volume       = {13},
  year         = {2017},
}

@article{681,
  abstract     = {Two-player games on graphs provide the theoretical framework for many important problems such as reactive synthesis. While the traditional study of two-player zero-sum games has been extended to multi-player games with several notions of equilibria, they are decidable only for perfect-information games, whereas several applications require imperfect-information. In this paper we propose a new notion of equilibria, called doomsday equilibria, which is a strategy profile where all players satisfy their own objective, and if any coalition of players deviates and violates even one of the players' objective, then the objective of every player is violated. We present algorithms and complexity results for deciding the existence of doomsday equilibria for various classes of ω-regular objectives, both for imperfect-information games, and for perfect-information games. We provide optimal complexity bounds for imperfect-information games, and in most cases for perfect-information games.},
  author       = {Chatterjee, Krishnendu and Doyen, Laurent and Filiot, Emmanuel and Raskin, Jean},
  issn         = {0890-5401},
  journal      = {Information and Computation},
  pages        = {296 -- 315},
  publisher    = {Elsevier},
  title        = {{Doomsday equilibria for omega-regular games}},
  doi          = {10.1016/j.ic.2016.10.012},
  volume       = {254},
  year         = {2017},
}

@inproceedings{683,
  abstract     = {Given a triangulation of a point set in the plane, a flip deletes an edge e whose removal leaves a convex quadrilateral, and replaces e by the opposite diagonal of the quadrilateral. It is well known that any triangulation of a point set can be reconfigured to any other triangulation by some sequence of flips. We explore this question in the setting where each edge of a triangulation has a label, and a flip transfers the label of the removed edge to the new edge. It is not true that every labelled triangulation of a point set can be reconfigured to every other labelled triangulation via a sequence of flips, but we characterize when this is possible. There is an obvious necessary condition: for each label l, if edge e has label l in the first triangulation and edge f has label l in the second triangulation, then there must be some sequence of flips that moves label l from e to f, ignoring all other labels. Bose, Lubiw, Pathak and Verdonschot formulated the Orbit Conjecture, which states that this necessary condition is also sufficient, i.e. that all labels can be simultaneously mapped to their destination if and only if each label individually can be mapped to its destination. We prove this conjecture. Furthermore, we give a polynomial-time algorithm to find a sequence of flips to reconfigure one labelled triangulation to another, if such a sequence exists, and we prove an upper bound of O(n7) on the length of the flip sequence. Our proof uses the topological result that the sets of pairwise non-crossing edges on a planar point set form a simplicial complex that is homeomorphic to a high-dimensional ball (this follows from a result of Orden and Santos; we give a different proof based on a shelling argument). The dual cell complex of this simplicial ball, called the flip complex, has the usual flip graph as its 1-skeleton. We use properties of the 2-skeleton of the flip complex to prove the Orbit Conjecture.},
  author       = {Lubiw, Anna and Masárová, Zuzana and Wagner, Uli},
  location     = {Brisbane, Australia},
  publisher    = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
  title        = {{A proof of the orbit conjecture for flipping edge labelled triangulations}},
  doi          = {10.4230/LIPIcs.SoCG.2017.49},
  volume       = {77},
  year         = {2017},
}

@article{684,
  abstract     = {We generalize winning conditions in two-player games by adding a structural acceptance condition called obligations. Obligations are orthogonal to the linear winning conditions that define whether a play is winning. Obligations are a declaration that player 0 can achieve a certain value from a configuration. If the obligation is met, the value of that configuration for player 0 is 1. We define the value in such games and show that obligation games are determined. For Markov chains with Borel objectives and obligations, and finite turn-based stochastic parity games with obligations we give an alternative and simpler characterization of the value function. Based on this simpler definition we show that the decision problem of winning finite turn-based stochastic parity games with obligations is in NP∩co-NP. We also show that obligation games provide a game framework for reasoning about p-automata. © 2017 The Association for Symbolic Logic.},
  author       = {Chatterjee, Krishnendu and Piterman, Nir},
  issn         = {1943-5886},
  journal      = {Journal of Symbolic Logic},
  number       = {2},
  pages        = {420 -- 452},
  publisher    = {Cambridge University Press},
  title        = {{Obligation blackwell games and p-automata}},
  doi          = {10.1017/jsl.2016.71},
  volume       = {82},
  year         = {2017},
}

@inproceedings{6841,
  abstract     = {In classical machine learning, regression is treated as a black box process of identifying a suitable function from a hypothesis set without attempting to gain insight into the mechanism connecting inputs and outputs. In the natural sciences, however, finding an interpretable function for a phenomenon is the prime goal as it allows to understand and generalize results. This paper proposes a novel type of function learning network, called equation learner (EQL), that can learn analytical expressions and is able to extrapolate to unseen domains. It is implemented as an end-to-end differentiable feed-forward network and allows for efficient gradient based training. Due to sparsity regularization concise interpretable expressions can be obtained. Often the true underlying source expression is identified.},
  author       = {Martius, Georg S and Lampert, Christoph},
  booktitle    = {5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings},
  location     = {Toulon, France},
  publisher    = {International Conference on Learning Representations},
  title        = {{Extrapolation and learning equations}},
  year         = {2017},
}

@article{685,
  abstract     = {By applying methods and principles from the physical sciences to biological problems, D'Arcy Thompson's On Growth and Form demonstrated how mathematical reasoning reveals elegant, simple explanations for seemingly complex processes. This has had a profound influence on subsequent generations of developmental biologists. We discuss how this influence can be traced through twentieth century morphologists, embryologists and theoreticians to current research that explores the molecular and cellular mechanisms of tissue growth and patterning, including our own studies of the vertebrate neural tube.},
  author       = {Briscoe, James and Kicheva, Anna},
  issn         = {0925-4773},
  journal      = {Mechanisms of Development},
  pages        = {26 -- 31},
  publisher    = {Elsevier},
  title        = {{The physics of development 100 years after D'Arcy Thompson's “on growth and form”}},
  doi          = {10.1016/j.mod.2017.03.005},
  volume       = {145},
  year         = {2017},
}

@article{686,
  abstract     = {Tissues are thought to behave like fluids with a given surface tension. Differences in tissue surface tension (TST) have been proposed to trigger cell sorting and tissue envelopment. D'Arcy Thompson in his seminal book ‘On Growth and Form’ has introduced this concept of differential TST as a key physical mechanism dictating tissue formation and organization within the developing organism. Over the past century, many studies have picked up the concept of differential TST and analyzed the role and cell biological basis of TST in development, underlining the importance and influence of this concept in developmental biology.},
  author       = {Heisenberg, Carl-Philipp J},
  issn         = {0925-4773},
  journal      = {Mechanisms of Development},
  pages        = {32 -- 37},
  publisher    = {Elsevier},
  title        = {{D'Arcy Thompson's ‘on growth and form’: From soap bubbles to tissue self organization}},
  doi          = {10.1016/j.mod.2017.03.006},
  volume       = {145},
  year         = {2017},
}

@article{687,
  abstract     = {Pursuing the similarity between the Kontsevich-Soibelman construction of the cohomological Hall algebra (CoHA) of BPS states and Lusztig's construction of canonical bases for quantum enveloping algebras, and the similarity between the integrality conjecture for motivic Donaldson-Thomas invariants and the PBW theorem for quantum enveloping algebras, we build a coproduct on the CoHA associated to a quiver with potential. We also prove a cohomological dimensional reduction theorem, further linking a special class of CoHAs with Yangians, and explaining how to connect the study of character varieties with the study of CoHAs.},
  author       = {Davison, Ben},
  issn         = {0033-5606},
  journal      = {Quarterly Journal of Mathematics},
  number       = {2},
  pages        = {635 -- 703},
  publisher    = {Oxford University Press},
  title        = {{The critical CoHA of a quiver with potential}},
  doi          = {10.1093/qmath/haw053},
  volume       = {68},
  year         = {2017},
}

@inproceedings{688,
  abstract     = {We show that the framework of topological data analysis can be extended from metrics to general Bregman divergences, widening the scope of possible applications. Examples are the Kullback - Leibler divergence, which is commonly used for comparing text and images, and the Itakura - Saito divergence, popular for speech and sound. In particular, we prove that appropriately generalized čech and Delaunay (alpha) complexes capture the correct homotopy type, namely that of the corresponding union of Bregman balls. Consequently, their filtrations give the correct persistence diagram, namely the one generated by the uniformly growing Bregman balls. Moreover, we show that unlike the metric setting, the filtration of Vietoris-Rips complexes may fail to approximate the persistence diagram. We propose algorithms to compute the thus generalized čech, Vietoris-Rips and Delaunay complexes and experimentally test their efficiency. Lastly, we explain their surprisingly good performance by making a connection with discrete Morse theory. },
  author       = {Edelsbrunner, Herbert and Wagner, Hubert},
  issn         = {1868-8969},
  location     = {Brisbane, Australia},
  pages        = {391--3916},
  publisher    = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
  title        = {{Topological data analysis with Bregman divergences}},
  doi          = {10.4230/LIPIcs.SoCG.2017.39},
  volume       = {77},
  year         = {2017},
}

@article{689,
  abstract     = {Rett syndrome modeling in monkey mirrors the human disorder.},
  author       = {Novarino, Gaia},
  issn         = {1946-6234},
  journal      = {Science Translational Medicine},
  number       = {393},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Rett syndrome modeling goes simian}},
  doi          = {10.1126/scitranslmed.aan8196},
  volume       = {9},
  year         = {2017},
}

@article{693,
  abstract     = {Many central synapses contain a single presynaptic active zone and a single postsynaptic density. Vesicular release statistics at such “simple synapses” indicate that they contain a small complement of docking sites where vesicles repetitively dock and fuse. In this work, we investigate functional and morphological aspects of docking sites at simple synapses made between cerebellar parallel fibers and molecular layer interneurons. Using immunogold labeling of SDS-treated freeze-fracture replicas, we find that Cav2.1 channels form several clusters per active zone with about nine channels per cluster. The mean value and range of intersynaptic variation are similar for Cav2.1 cluster numbers and for functional estimates of docking-site numbers obtained from the maximum numbers of released vesicles per action potential. Both numbers grow in relation with synaptic size and decrease by a similar extent with age between 2 wk and 4 wk postnatal. Thus, the mean docking-site numbers were 3.15 at 2 wk (range: 1–10) and 2.03 at 4 wk (range: 1–4), whereas the mean numbers of Cav2.1 clusters were 2.84 at 2 wk (range: 1–8) and 2.37 at 4 wk (range: 1–5). These changes were accompanied by decreases of miniature current amplitude (from 93 pA to 56 pA), active-zone surface area (from 0.0427 μm2 to 0.0234 μm2), and initial success rate (from 0.609 to 0.353), indicating a tightening of synaptic transmission with development. Altogether, these results suggest a close correspondence between the number of functionally defined vesicular docking sites and that of clusters of voltage-gated calcium channels. },
  author       = {Miki, Takafumi and Kaufmann, Walter and Malagon, Gerardo and Gomez, Laura and Tabuchi, Katsuhiko and Watanabe, Masahiko and Shigemoto, Ryuichi and Marty, Alain},
  issn         = {0027-8424},
  journal      = {PNAS},
  number       = {26},
  pages        = {E5246 -- E5255},
  publisher    = {National Academy of Sciences},
  title        = {{Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses}},
  doi          = {10.1073/pnas.1704470114},
  volume       = {114},
  year         = {2017},
}

@article{694,
  abstract     = {A change regarding the extent of adhesion - hereafter referred to as adhesion plasticity - between adhesive and less-adhesive states of mammalian cells is important for their behavior. To investigate adhesion plasticity, we have selected a stable isogenic subpopulation of human MDA-MB-468 breast carcinoma cells growing in suspension. These suspension cells are unable to re-adhere to various matrices or to contract three-dimensional collagen lattices. By using transcriptome analysis, we identified the focal adhesion protein tensin3 (Tns3) as a determinant of adhesion plasticity. Tns3 is strongly reduced at mRNA and protein levels in suspension cells. Furthermore, by transiently challenging breast cancer cells to grow under non-adherent conditions markedly reduces Tns3 protein expression, which is regained upon re-adhesion. Stable knockdown of Tns3 in parental MDA-MB-468 cells results in defective adhesion, spreading and migration. Tns3-knockdown cells display impaired structure and dynamics of focal adhesion complexes as determined by immunostaining. Restoration of Tns3 protein expression in suspension cells partially rescues adhesion and focal contact composition. Our work identifies Tns3 as a crucial focal adhesion component regulated by, and functionally contributing to, the switch between adhesive and non-adhesive states in MDA-MB-468 cancer cells.},
  author       = {Veß, Astrid and Blache, Ulrich and Leitner, Laura and Kurz, Angela and Ehrenpfordt, Anja and Sixt, Michael K and Posern, Guido},
  issn         = {0021-9533},
  journal      = {Journal of Cell Science},
  number       = {13},
  pages        = {2172 -- 2184},
  publisher    = {Company of Biologists},
  title        = {{A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity}},
  doi          = {10.1242/jcs.200899},
  volume       = {130},
  year         = {2017},
}

@inproceedings{697,
  abstract     = {De, Trevisan and Tulsiani [CRYPTO 2010] show that every distribution over n-bit strings which has constant statistical distance to uniform (e.g., the output of a pseudorandom generator mapping n-1 to n bit strings), can be distinguished from the uniform distribution with advantage epsilon by a circuit of size O( 2^n epsilon^2). We generalize this result, showing that a distribution which has less than k bits of min-entropy, can be distinguished from any distribution with k bits of delta-smooth min-entropy with advantage epsilon by a circuit of size O(2^k epsilon^2/delta^2). As a special case, this implies that any distribution with support at most 2^k (e.g., the output of a pseudoentropy generator mapping k to n bit strings) can be distinguished from any given distribution with min-entropy k+1 with advantage epsilon by a circuit of size O(2^k epsilon^2). Our result thus shows that pseudoentropy distributions face basically the same non-uniform attacks as pseudorandom distributions. },
  author       = {Pietrzak, Krzysztof Z and Skórski, Maciej},
  issn         = {1868-8969},
  location     = {Warsaw, Poland},
  publisher    = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
  title        = {{Non uniform attacks against pseudoentropy}},
  doi          = {10.4230/LIPIcs.ICALP.2017.39},
  volume       = {80},
  year         = {2017},
}

@article{698,
  abstract     = {Extracellular matrix signals from the microenvironment regulate gene expression patterns and cell behavior. Using a combination of experiments and geometric models, we demonstrate correlations between cell geometry, three-dimensional (3D) organization of chromosome territories, and gene expression. Fluorescence in situ hybridization experiments showed that micropatterned fibroblasts cultured on anisotropic versus isotropic substrates resulted in repositioning of specific chromosomes, which contained genes that were differentially regulated by cell geometries. Experiments combined with ellipsoid packing models revealed that the mechanosensitivity of chromosomes was correlated with their orientation in the nucleus. Transcription inhibition experiments suggested that the intermingling degree was more sensitive to global changes in transcription than to chromosome radial positioning and its orientations. These results suggested that cell geometry modulated 3D chromosome arrangement, and their neighborhoods correlated with gene expression patterns in a predictable manner. This is central to understanding geometric control of genetic programs involved in cellular homeostasis and the associated diseases. },
  author       = {Wang, Yejun and Nagarajan, Mallika and Uhler, Caroline and Shivashankar, Gv},
  issn         = {1059-1524},
  journal      = {Molecular Biology of the Cell},
  number       = {14},
  pages        = {1997 -- 2009},
  publisher    = {American Society for Cell Biology},
  title        = {{Orientation and repositioning of chromosomes correlate with cell geometry dependent gene expression}},
  doi          = {10.1091/mbc.E16-12-0825},
  volume       = {28},
  year         = {2017},
}

@article{699,
  abstract     = {In antagonistic symbioses, such as host–parasite interactions, one population’s success is the other’s loss. In mutualistic symbioses, such as division of labor, both parties can gain, but they might have different preferences over the possible mutualistic arrangements. The rates of evolution of the two populations in a symbiosis are important determinants of which population will be more successful: Faster evolution is thought to be favored in antagonistic symbioses (the “Red Queen effect”), but disfavored in certain mutualistic symbioses (the “Red King effect”). However, it remains unclear which biological parameters drive these effects. Here, we analyze the effects of the various determinants of evolutionary rate: generation time, mutation rate, population size, and the intensity of natural selection. Our main results hold for the case where mutation is infrequent. Slower evolution causes a long-term advantage in an important class of mutualistic interactions. Surprisingly, less intense selection is the strongest driver of this Red King effect, whereas relative mutation rates and generation times have little effect. In antagonistic interactions, faster evolution by any means is beneficial. Our results provide insight into the demographic evolution of symbionts. },
  author       = {Veller, Carl and Hayward, Laura and Nowak, Martin and Hilbe, Christian},
  issn         = {0027-8424},
  journal      = {PNAS},
  number       = {27},
  pages        = {E5396 -- E5405},
  publisher    = {National Academy of Sciences},
  title        = {{The red queen and king in finite populations}},
  doi          = {10.1073/pnas.1702020114},
  volume       = {114},
  year         = {2017},
}

@article{702,
  abstract     = {Leading autism-associated mutation in mouse partially mimics human disorder.

},
  author       = {Novarino, Gaia},
  issn         = {1946-6234},
  journal      = {Science Translational Medicine},
  number       = {399},
  pages        = {eaao0972},
  publisher    = {American Association for the Advancement of Science},
  title        = {{The riddle of CHD8 haploinsufficiency in autism spectrum disorder}},
  doi          = {10.1126/scitranslmed.aao0972},
  volume       = {9},
  year         = {2017},
}

@article{706,
  abstract     = {A hippocampal mossy fiber synapse has a complex structure and is implicated in learning and memory. In this synapse, the mossy fiber boutons attach to the dendritic shaft by puncta adherentia junctions and wrap around a multiply-branched spine, forming synaptic junctions. We have recently shown using transmission electron microscopy, immunoelectron microscopy and serial block face-scanning electron microscopy that atypical puncta adherentia junctions are formed in the afadin-deficient mossy fiber synapse and that the complexity of postsynaptic spines and mossy fiber boutons, the number of spine heads, the area of postsynaptic densities and the density of synaptic vesicles docked to active zones are decreased in the afadin-deficient synapse. We investigated here the roles of afadin in the functional differentiations of the mossy fiber synapse using the afadin-deficient mice. The electrophysiological studies showed that both the release probability of glutamate and the postsynaptic responsiveness to glutamate were markedly reduced, but not completely lost, in the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation nor long-term depression was affected. These results indicate that afadin plays roles in the functional differentiations of the presynapse and the postsynapse of the hippocampal mossy fiber synapse.},
  author       = {Geng, Xiaoqi and Maruo, Tomohiko and Mandai, Kenji and Supriyanto, Irwan and Miyata, Muneaki and Sakakibara, Shotaro and Mizoguchi, Akira and Takai, Yoshimi and Mori, Masahiro},
  issn         = {1356-9597},
  journal      = {Genes to Cells},
  number       = {8},
  pages        = {715 -- 722},
  publisher    = {Wiley-Blackwell},
  title        = {{Roles of afadin in functional differentiations of hippocampal mossy fiber synapse}},
  doi          = {10.1111/gtc.12508},
  volume       = {22},
  year         = {2017},
}

@article{707,
  abstract     = {We answer a question of M. Gromov on the waist of the unit ball.},
  author       = {Akopyan, Arseniy and Karasev, Roman},
  issn         = {0024-6093},
  journal      = {Bulletin of the London Mathematical Society},
  number       = {4},
  pages        = {690 -- 693},
  publisher    = {Wiley},
  title        = {{A tight estimate for the waist of the ball }},
  doi          = {10.1112/blms.12062},
  volume       = {49},
  year         = {2017},
}

@article{708,
  abstract     = {In the developing and adult brain, oligodendrocyte precursor cells (OPCs) are influenced by neuronal activity: they are involved in synaptic signaling with neurons, and their proliferation and differentiation into myelinating glia can be altered by transient changes in neuronal firing. An important question that has been unanswered is whether OPCs can discriminate different patterns of neuronal activity and respond to them in a distinct way. Here, we demonstrate in brain slices that the pattern of neuronal activity determines the functional changes triggered at synapses between axons and OPCs. Furthermore, we show that stimulation of the corpus callosum at different frequencies in vivo affects proliferation and differentiation of OPCs in a dissimilar way. Our findings suggest that neurons do not influence OPCs in “all-or-none” fashion but use their firing pattern to tune the response and behavior of these nonneuronal cells.},
  author       = {Nagy, Balint and Hovhannisyan, Anahit and Barzan, Ruxandra and Chen, Ting and Kukley, Maria},
  issn         = {1544-9173},
  journal      = {PLoS Biology},
  number       = {8},
  publisher    = {Public Library of Science},
  title        = {{Different patterns of neuronal activity trigger distinct responses of oligodendrocyte precursor cells in the corpus callosum}},
  doi          = {10.1371/journal.pbio.2001993},
  volume       = {15},
  year         = {2017},
}

@article{709,
  abstract     = {Adipose tissues play key roles in energy homeostasis. Brown adipocytes and beige adipocytes in white adipose tissue (WAT) share the similar characters of thermogenesis, both of them could be potential targets for obesity management. Several thermo-sensitive transient receptor potential channels (thermoTRPs) are shown to be involved in adipocyte biology. However, the expression pattern of thermoTRPs in adipose tissues from obese mice is still unknown. The mRNA expression of thermoTRPs in subcutaneous WAT (sWAT) and interscapular brown adipose tissue (iBAT) from lean and obese mice were measured using reverse transcriptase-quantitative PCRs (RT-qPCR). The results demonstrated that all 10 thermoTRPs are expressed in both iBAT and sWAT, and without significant difference in the mRNA expression level of thermoTRPs between these two tissues. Moreover, Trpv1 and Trpv3 mRNA expression levels in both iBAT and sWAT were significantly decreased in high fat diet (HFD)-induced obese mice and db/db (leptin receptor deficient) mice. Trpm2 mRNA expression level was significantly decreased only in sWAT from HFD-induced obese mice and db/db mice. On the other hand, Trpv2 and Trpv4 mRNA expression levels in iBAT and sWAT were significantly increased in HFD-induced obese mice and db/db mice. Taken together, we conclude that all 10 thermoTRPs are expressed in iBAT and sWAT. And several thermoTRPs differentially expressed in adipose tissues from HFD-induced obese mice and db/db mice, suggesting a potential involvement in anti-obesity regulations.},
  author       = {Sun, Wuping and Li, Chen and Zhang, Yonghong and Jiang, Changyu and Zhai, Ming-Zhu and Zhou, Qian and Xiao, Lizu and Deng, Qiwen},
  issn         = {1065-6995},
  journal      = {Cell Biology International},
  number       = {8},
  pages        = {908 -- 913},
  publisher    = {Wiley-Blackwell},
  title        = {{Gene expression changes of thermo sensitive transient receptor potential channels in obese mice}},
  doi          = {10.1002/cbin.10783},
  volume       = {41},
  year         = {2017},
}