[{"related_material":{"link":[{"relation":"software","url":"https://github.com/paloha/faket/"}]},"oa":1,"date_updated":"2026-10-20T08:54:10Z","isi":1,"file":[{"access_level":"open_access","date_created":"2025-08-05T12:15:13Z","content_type":"application/pdf","file_size":4367530,"checksum":"f346bc357a66a88cca3d0eb95793fb73","relation":"main_file","creator":"dernst","file_name":"2025_Structure_Harar.pdf","success":1,"date_updated":"2025-08-05T12:15:13Z","file_id":"20130"}],"oa_version":"Published Version","publication":"Structure","intvolume":"        33","file_date_updated":"2025-08-05T12:15:13Z","_id":"19443","month":"04","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-03-23T23:01:27Z","article_type":"original","department":[{"_id":"AlMi"}],"acknowledgement":"The IMP and D.H. are generously funded by Boehringer Ingelheim. We thank Julius Berner from the Mathematical Data Science group @ UniVie, Ilja Gubins and Marten Chaillet from the SHREC team, and the members of the Haselbach lab for helpful discussions.","title":"FakET: Simulating cryo-electron tomograms with neural style transfer","abstract":[{"text":"In cryo-electron microscopy, accurate particle localization and classification are imperative. Recent deep learning solutions, though successful, require extensive training datasets. The protracted generation time of physics-based models, often employed to produce these datasets, limits their broad applicability. We introduce FakET, a method based on neural style transfer, capable of simulating the forward operator of any cryo transmission electron microscope. It can be used to adapt a synthetic training dataset according to reference data producing high-quality simulated micrographs or tilt-series. To assess the quality of our generated data, we used it to train a state-of-the-art localization and classification architecture and compared its performance with a counterpart trained on benchmark data. Remarkably, our technique matches the performance, boosts data generation speed 750x, uses 33x less memory, and scales well to typical transmission electron microscope detector sizes. It leverages GPU acceleration and parallel processing. The source code is available at https://github.com/paloha/faket/.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by/4.0/","quality_controlled":"1","publisher":"Cell Press","status":"public","issue":"4","doi":"10.1016/j.str.2025.01.020","OA_type":"hybrid","citation":{"mla":"Harar, Pavol, et al. “FakET: Simulating Cryo-Electron Tomograms with Neural Style Transfer.” <i>Structure</i>, vol. 33, no. 4, Cell Press, 2025, p. 820–827.e4, doi:<a href=\"https://doi.org/10.1016/j.str.2025.01.020\">10.1016/j.str.2025.01.020</a>.","ama":"Harar P, Herrmann L, Grohs P, Haselbach D. FakET: Simulating cryo-electron tomograms with neural style transfer. <i>Structure</i>. 2025;33(4):820-827.e4. doi:<a href=\"https://doi.org/10.1016/j.str.2025.01.020\">10.1016/j.str.2025.01.020</a>","ista":"Harar P, Herrmann L, Grohs P, Haselbach D. 2025. FakET: Simulating cryo-electron tomograms with neural style transfer. Structure. 33(4), 820–827.e4.","ieee":"P. Harar, L. Herrmann, P. Grohs, and D. Haselbach, “FakET: Simulating cryo-electron tomograms with neural style transfer,” <i>Structure</i>, vol. 33, no. 4. Cell Press, p. 820–827.e4, 2025.","short":"P. Harar, L. Herrmann, P. Grohs, D. Haselbach, Structure 33 (2025) 820–827.e4.","apa":"Harar, P., Herrmann, L., Grohs, P., &#38; Haselbach, D. (2025). FakET: Simulating cryo-electron tomograms with neural style transfer. <i>Structure</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.str.2025.01.020\">https://doi.org/10.1016/j.str.2025.01.020</a>","chicago":"Harar, Pavol, Lukas Herrmann, Philipp Grohs, and David Haselbach. “FakET: Simulating Cryo-Electron Tomograms with Neural Style Transfer.” <i>Structure</i>. Cell Press, 2025. <a href=\"https://doi.org/10.1016/j.str.2025.01.020\">https://doi.org/10.1016/j.str.2025.01.020</a>."},"publication_status":"published","OA_place":"publisher","volume":33,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2025","language":[{"iso":"eng"}],"external_id":{"isi":["001463196100001"],"pmid":["39947174"]},"pmid":1,"date_published":"2025-04-03T00:00:00Z","has_accepted_license":"1","fulldoi":"https://doi.org/10.1016/j.str.2025.01.020","ddc":["570"],"type":"journal_article","article_processing_charge":"Yes (in subscription journal)","PlanS_conform":"1","day":"03","publication_identifier":{"eissn":["1878-4186"],"issn":["0969-2126"]},"scopus_import":"1","author":[{"last_name":"Harar","orcid":"0000-0001-5206-1794","id":"e03d953a-6e8c-11ef-99e4-f0717d385cd5","first_name":"Pavol","full_name":"Harar, Pavol"},{"full_name":"Herrmann, Lukas","first_name":"Lukas","last_name":"Herrmann"},{"last_name":"Grohs","full_name":"Grohs, Philipp","first_name":"Philipp"},{"last_name":"Haselbach","first_name":"David","full_name":"Haselbach, David"}],"corr_author":"1","page":"820-827.e4"},{"page":"645-654","corr_author":"1","scopus_import":"1","publication_identifier":{"issn":["0166-2236"],"eissn":["1878-108X"]},"author":[{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"Hetzer, Martin W","orcid":"0000-0002-2111-992X","last_name":"Hetzer"},{"first_name":"Tomohisa","full_name":"Toda, Tomohisa","last_name":"Toda"}],"day":"01","type":"journal_article","PlanS_conform":"1","article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","ddc":["570"],"fulldoi":"https://doi.org/10.1016/j.tins.2025.07.004","date_published":"2025-09-01T00:00:00Z","external_id":{"pmid":["40744775"],"isi":["001568965400001"]},"pmid":1,"language":[{"iso":"eng"}],"OA_place":"publisher","publication_status":"published","citation":{"short":"M. Hetzer, T. Toda, Trends in Neurosciences 48 (2025) 645–654.","ieee":"M. Hetzer and T. Toda, “Long-lived cellular molecules in the brain,” <i>Trends in Neurosciences</i>, vol. 48, no. 9. Cell Press, pp. 645–654, 2025.","chicago":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>. Cell Press, 2025. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>.","apa":"Hetzer, M., &#38; Toda, T. (2025). Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>","ama":"Hetzer M, Toda T. Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. 2025;48(9):645-654. doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>","mla":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>, vol. 48, no. 9, Cell Press, 2025, pp. 645–54, doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>.","ista":"Hetzer M, Toda T. 2025. Long-lived cellular molecules in the brain. Trends in Neurosciences. 48(9), 645–654."},"year":"2025","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":48,"doi":"10.1016/j.tins.2025.07.004","OA_type":"hybrid","quality_controlled":"1","issue":"9","status":"public","publisher":"Cell Press","acknowledgement":"The work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (470322152 – T1347/3-1; 497658532 – T1347/4-1; 507965872 – T1347/5-1; and 460333672 – CRC1540 Exploring Brain Mechanics) to T.T., the Schram Foundation (T.T.), the European Research Council (ERC-2018-STG, 804468 EAGER; ERC-2023-COG, 101125034 NEUTIME) to T.T., the Hans-Georg Geis und Xue Hong Dong-Geis Foundation and Forschungsstiftung Medizin am Universitätsklinikum Erlangen to T.T., and the Interdisciplinary Centre for Clinical Research Erlangen (Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Erlangen; P162 to T.T.). We thank Dr Laura J. Harrison for editing assistance.","abstract":[{"lang":"eng","text":"In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity."}],"title":"Long-lived cellular molecules in the brain","date_created":"2025-08-10T22:01:29Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MaHe"}],"article_type":"original","_id":"20154","month":"09","oa_version":"Published Version","publication":"Trends in Neurosciences","file_date_updated":"2025-12-29T13:47:27Z","intvolume":"        48","date_updated":"2026-10-20T08:54:50Z","isi":1,"file":[{"content_type":"application/pdf","date_created":"2025-12-29T13:47:27Z","access_level":"open_access","relation":"main_file","checksum":"90942491b499f70b0bf48b8aec2e7387","file_size":327847,"file_name":"2025_TrendsNeurosciences_Hetzer.pdf","creator":"dernst","file_id":"20873","date_updated":"2025-12-29T13:47:27Z","success":1}],"oa":1},{"isi":1,"date_updated":"2026-10-20T08:55:09Z","publication":"Current Biology","oa_version":"None","intvolume":"        35","_id":"20427","month":"09","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-10-05T22:01:35Z","article_type":"letter_note","department":[{"_id":"MiSi"}],"abstract":[{"lang":"eng","text":"Animal cells migrating up chemotactic gradients often show speed oscillations. A new study describes a molecular circuit that switches zebrafish germ cells between phases of straight runs, tumbling and directional reorientation."}],"title":"Cell migration: How animal cells run and tumble","quality_controlled":"1","publisher":"Cell Press","issue":"18","status":"public","doi":"10.1016/j.cub.2025.08.016","OA_type":"closed access","publication_status":"published","citation":{"ama":"LI Z, Sixt MK. Cell migration: How animal cells run and tumble. <i>Current Biology</i>. 2025;35(18):R890-R892. doi:<a href=\"https://doi.org/10.1016/j.cub.2025.08.016\">10.1016/j.cub.2025.08.016</a>","mla":"LI, ZIQIANG, and Michael K. Sixt. “Cell Migration: How Animal Cells Run and Tumble.” <i>Current Biology</i>, vol. 35, no. 18, Cell Press, 2025, pp. R890–92, doi:<a href=\"https://doi.org/10.1016/j.cub.2025.08.016\">10.1016/j.cub.2025.08.016</a>.","ista":"LI Z, Sixt MK. 2025. Cell migration: How animal cells run and tumble. Current Biology. 35(18), R890–R892.","short":"Z. LI, M.K. Sixt, Current Biology 35 (2025) R890–R892.","ieee":"Z. LI and M. K. Sixt, “Cell migration: How animal cells run and tumble,” <i>Current Biology</i>, vol. 35, no. 18. Cell Press, pp. R890–R892, 2025.","chicago":"LI, ZIQIANG, and Michael K Sixt. “Cell Migration: How Animal Cells Run and Tumble.” <i>Current Biology</i>. Cell Press, 2025. <a href=\"https://doi.org/10.1016/j.cub.2025.08.016\">https://doi.org/10.1016/j.cub.2025.08.016</a>.","apa":"LI, Z., &#38; Sixt, M. K. (2025). Cell migration: How animal cells run and tumble. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2025.08.016\">https://doi.org/10.1016/j.cub.2025.08.016</a>"},"year":"2025","volume":35,"language":[{"iso":"eng"}],"pmid":1,"external_id":{"isi":["001592664700001"],"pmid":["40987270"]},"date_published":"2025-09-22T00:00:00Z","fulldoi":"https://doi.org/10.1016/j.cub.2025.08.016","type":"journal_article","article_processing_charge":"No","day":"22","publication_identifier":{"eissn":["1879-0445"]},"scopus_import":"1","author":[{"id":"922e68bb-1727-11ee-857c-966e8cc1b6c3","first_name":"Ziqiang","full_name":"Li, Ziqiang","last_name":"Li"},{"full_name":"Sixt, Michael K","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-6620-9179"}],"page":"R890-R892","corr_author":"1"},{"date_updated":"2026-10-20T08:56:33Z","file":[{"success":1,"date_updated":"2025-06-04T05:43:27Z","file_id":"19790","file_name":"2025_DevelopmentalCell_Jaeger.pdf","creator":"dernst","relation":"main_file","checksum":"a83a4cb58f5941096d3ad91ca0172594","file_size":11936258,"date_created":"2025-06-04T05:43:27Z","content_type":"application/pdf","access_level":"open_access"}],"isi":1,"oa":1,"related_material":{"record":[{"id":"22667","status":"public","relation":"dissertation_contains"},{"status":"public","id":"22803","relation":"research_data"}]},"das_tickbox":"1","file_date_updated":"2025-06-04T05:43:27Z","intvolume":"        60","oa_version":"Published Version","publication":"Developmental Cell","dataavailabilitystatement":"FAMD RStudio code and raw data used for analysis of post-metamorphic P. waltl injection outcomes are available via Dryad repository: https://doi.org/10.5061/dryad.mpg4f4r89. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","month":"03","_id":"15016","department":[{"_id":"LoSw"},{"_id":"MaDe"},{"_id":"GaNo"}],"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2024-02-20T09:20:32Z","title":"Adeno-associated viral tools to trace neural development and connectivity across amphibians","abstract":[{"text":"Amphibians, by virtue of their phylogenetic position, provide invaluable insights on nervous system evolution, development, and remodeling. The genetic toolkit for amphibians, however, remains limited. Recombinant adeno-associated viral vectors (AAVs) are a powerful alternative to transgenesis for labeling and manipulating neurons. Although successful in mammals, AAVs have never been shown to transduce amphibian cells efficiently. We screened AAVs in three amphibian species—the frogs Xenopus laevis and Pelophylax bedriagae and the salamander Pleurodeles waltl—and identified at least two AAV serotypes per species that transduce neurons. In developing amphibians, AAVs labeled groups of neurons generated at the same time during development. In the mature brain, AAVrg retrogradely traced long-range projections. Our study introduces AAVs as a tool for amphibian research, establishes a generalizable workflow for AAV screening in new species, and expands opportunities for cross-species comparisons of nervous system development, function, and evolution.","lang":"eng"}],"acknowledgement":"We thank members of the Sweeney, Tosches, Shein-Idelson, Yamaguchi, Kelley, and Cline Labs for their contributions to this project, discussion, and support. We additionally thank the Beckman Institute CLOVER Center and Viviana Gradinaru (Caltech), Kimberly Ritola (UNC NeuroTools), and Flavia Gomez-Leite (ISTA Viral Core) for AAV production and consultation; Andras Simon and Alberto Joven (Karolinska Institute) for feedback; Elizabeth Bagnato-Cohen (Columbia) for project coordination; our animal care and imaging facilities; the amphibian stock centers (NXR, EXRC, and XenopusExpress); and our funding sources: NSF IOS 2110086 (D.B.K., L.B.S., M.A.T., A.Y., and H.T.C.); US-Israel Binational Science Foundation (BSF) 2020702 (M.S.-I.); FTI Strategy Lower Austria Dissertation FT121-D-046 (D.V.); Horizon Europe ERC Starting Grant 101041551 and Special Research Programme (SFB) of the Austrian Science Fund (FWF) project F7814-B (L.B.S.); NIH grant R35GM146973, Rita Allen Foundation Award GA_032522_FE, and CZI Ben Barres Early Career Acceleration Award 2023-331758 (M.A.T.); EMBO Long-Term Fellowship ALTF 874-2021 (A.D.); and NSF GRFP DGE 2036197 (E.C.B.J.).","status":"public","issue":"5","publisher":"Cell Press","project":[{"name":"Development of V1 interneuron diversity during swim-to-walk transition of Xenopus metamorphosis","_id":"bd73af52-d553-11ed-ba76-912049f0ac7a","grant_number":"FTI21-D-046"},{"name":"Development and Evolution of Tetrapod Motor Circuits","_id":"ebb66355-77a9-11ec-83b8-b8ac210a4dae","grant_number":"101041551"},{"grant_number":"F7814","_id":"8da85f50-16d5-11f0-9cad-eab8b0ff6c9e","name":"Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb transition: cell type to connection diversity"}],"quality_controlled":"1","OA_type":"hybrid","doi":"10.1016/j.devcel.2024.10.025","volume":60,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2025","researchdata_availability":"yes","OA_place":"publisher","citation":{"chicago":"Jaeger, Eliza C.B., David Vijatovic, Astrid Deryckere, Nikol Zorin, Akemi L. Nguyen, Georgiy Ivanian, Jamie Woych, et al. “Adeno-Associated Viral Tools to Trace Neural Development and Connectivity across Amphibians.” <i>Developmental Cell</i>. Cell Press, 2025. <a href=\"https://doi.org/10.1016/j.devcel.2024.10.025\">https://doi.org/10.1016/j.devcel.2024.10.025</a>.","apa":"Jaeger, E. C. B., Vijatovic, D., Deryckere, A., Zorin, N., Nguyen, A. L., Ivanian, G., … Sweeney, L. B. (2025). Adeno-associated viral tools to trace neural development and connectivity across amphibians. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2024.10.025\">https://doi.org/10.1016/j.devcel.2024.10.025</a>","short":"E.C.B. Jaeger, D. Vijatovic, A. Deryckere, N. Zorin, A.L. Nguyen, G. Ivanian, J. Woych, R.C. Arnold, A. Ortega Gurrola, A. Shvartsman, F. Barbieri, F.-A. Toma, G.J. Gorbsky, M.E. Horb, H.T. Cline, T.F. Shay, D.B. Kelley, A. Yamaguchi, M. Shein-Idelson, M.A. Tosches, L.B. Sweeney, Developmental Cell 60 (2025) 794–812.e6.","ieee":"E. C. B. Jaeger <i>et al.</i>, “Adeno-associated viral tools to trace neural development and connectivity across amphibians,” <i>Developmental Cell</i>, vol. 60, no. 5. Cell Press, p. 794–812.e6, 2025.","ista":"Jaeger ECB, Vijatovic D, Deryckere A, Zorin N, Nguyen AL, Ivanian G, Woych J, Arnold RC, Ortega Gurrola A, Shvartsman A, Barbieri F, Toma F-A, Gorbsky GJ, Horb ME, Cline HT, Shay TF, Kelley DB, Yamaguchi A, Shein-Idelson M, Tosches MA, Sweeney LB. 2025. Adeno-associated viral tools to trace neural development and connectivity across amphibians. Developmental Cell. 60(5), 794–812.e6.","ama":"Jaeger ECB, Vijatovic D, Deryckere A, et al. Adeno-associated viral tools to trace neural development and connectivity across amphibians. <i>Developmental Cell</i>. 2025;60(5):794-812.e6. doi:<a href=\"https://doi.org/10.1016/j.devcel.2024.10.025\">10.1016/j.devcel.2024.10.025</a>","mla":"Jaeger, Eliza C. B., et al. “Adeno-Associated Viral Tools to Trace Neural Development and Connectivity across Amphibians.” <i>Developmental Cell</i>, vol. 60, no. 5, Cell Press, 2025, p. 794–812.e6, doi:<a href=\"https://doi.org/10.1016/j.devcel.2024.10.025\">10.1016/j.devcel.2024.10.025</a>."},"publication_status":"published","language":[{"iso":"eng"}],"pmid":1,"external_id":{"isi":["001444798600001"],"pmid":["39603234"]},"date_published":"2025-03-10T00:00:00Z","ddc":["570"],"fulldoi":"https://doi.org/10.1016/j.devcel.2024.10.025","has_accepted_license":"1","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"}],"article_processing_charge":"Yes (via OA deal)","type":"journal_article","day":"10","author":[{"first_name":"Eliza C.B.","full_name":"Jaeger, Eliza C.B.","last_name":"Jaeger"},{"full_name":"Vijatovic, David","id":"cf391e77-ec3c-11ea-a124-d69323410b58","first_name":"David","last_name":"Vijatovic","orcid":"0000-0002-5494-0941"},{"first_name":"Astrid","full_name":"Deryckere, Astrid","last_name":"Deryckere"},{"full_name":"Zorin, Nikol","first_name":"Nikol","last_name":"Zorin"},{"last_name":"Nguyen","full_name":"Nguyen, Akemi L.","first_name":"Akemi L."},{"first_name":"Georgiy","id":"eaf2b366-cfd1-11ee-bbdf-c8790f800a05","full_name":"Ivanian, Georgiy","last_name":"Ivanian","orcid":"0009-0002-3999-3735"},{"last_name":"Woych","full_name":"Woych, Jamie","first_name":"Jamie"},{"last_name":"Arnold","full_name":"Arnold, Rebecca C","first_name":"Rebecca C","id":"d6cce458-14c9-11ed-a755-c1c8fc6fde6f"},{"last_name":"Ortega Gurrola","full_name":"Ortega Gurrola, Alonso","first_name":"Alonso"},{"first_name":"Arik","full_name":"Shvartsman, Arik","last_name":"Shvartsman"},{"full_name":"Barbieri, Francesca","id":"a9492887-8972-11ed-ae7b-bfae10998254","first_name":"Francesca","last_name":"Barbieri"},{"last_name":"Toma","first_name":"Florina-Alexandra","id":"85dd99f2-15b2-11ec-abd3-d1ae4d57f3b5","full_name":"Toma, Florina-Alexandra"},{"last_name":"Gorbsky","first_name":"Gary J.","full_name":"Gorbsky, Gary J."},{"last_name":"Horb","first_name":"Marko E.","full_name":"Horb, Marko E."},{"full_name":"Cline, Hollis T.","first_name":"Hollis T.","last_name":"Cline"},{"full_name":"Shay, Timothy F.","first_name":"Timothy F.","last_name":"Shay"},{"full_name":"Kelley, Darcy B.","first_name":"Darcy B.","last_name":"Kelley"},{"full_name":"Yamaguchi, Ayako","first_name":"Ayako","last_name":"Yamaguchi"},{"last_name":"Shein-Idelson","first_name":"Mark","full_name":"Shein-Idelson, Mark"},{"first_name":"Maria Antonietta","full_name":"Tosches, Maria Antonietta","last_name":"Tosches"},{"full_name":"Sweeney, Lora Beatrice Jaeger","first_name":"Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","orcid":"0000-0001-9242-5601","last_name":"Sweeney"}],"publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"scopus_import":"1","supplementarymaterial":"yes","page":"794-812.e6","corr_author":"1"},{"issue":"1","status":"public","publisher":"Cell Press","quality_controlled":"1","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","title":"Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1","abstract":[{"lang":"eng","text":"Brassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signalling initiation, which requires binding of BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter, ABCB19, functions as a BR exporter, and together with its close homologue, ABCB1, positively regulate BR signalling. Here, we demonstrate that ABCB1 is another BR transporter. The ATP hydrolysis activity of ABCB1 was stimulated by bioactive BRs, and its transport activity was confirmed in proteoliposomes and protoplasts. Structures of ABCB1 in substrate-unbound (apo), brassinolide (BL)-bound, and ATP plus BL-bound states were determined. In the BL-bound structure, BL was bound to the hydrophobic cavity formed by the transmembrane domain, and triggered local conformational changes. Together, our data provide additional insights into the ABC transporter-mediated BR export."}],"acknowledgement":"We thank the Cryo-EM Center of the University of Science and Technology of China for the EM facility support. We thank Yaowei Wang, Yongming Luo, and Nemanja Vukašinović (VIB-UGhent, Belgium) for useful discussions and technical support. L.S. is supported by an Outstanding Young Scholar Award from the Qiu Shi Science and Technologies Foundation and a Young Scholar Award from the Cyrus Tang Foundation. No conflict of interest is declared.","year":"2025","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"volume":6,"researchdata_availability":"yes","citation":{"ista":"Wei H, Zhu H, Ying W, Janssens H, Kvasnica M, Winne J, Gao Y, Friml J, Ma Q, Tan S, Liu X, Russinova E, Sun L. 2025. Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1. Plant Communications. 6(1), 101181.","ama":"Wei H, Zhu H, Ying W, et al. Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1. <i>Plant Communications</i>. 2025;6(1). doi:<a href=\"https://doi.org/10.1016/j.xplc.2024.101181\">10.1016/j.xplc.2024.101181</a>","mla":"Wei, H., et al. “Structural Insights into Brassinosteroid Export Mediated by the Arabidopsis ABC Transporter ABCB1.” <i>Plant Communications</i>, vol. 6, no. 1, 101181, Cell Press, 2025, doi:<a href=\"https://doi.org/10.1016/j.xplc.2024.101181\">10.1016/j.xplc.2024.101181</a>.","chicago":"Wei, H, H Zhu, W Ying, H Janssens, M Kvasnica, JM Winne, Y Gao, et al. “Structural Insights into Brassinosteroid Export Mediated by the Arabidopsis ABC Transporter ABCB1.” <i>Plant Communications</i>. Cell Press, 2025. <a href=\"https://doi.org/10.1016/j.xplc.2024.101181\">https://doi.org/10.1016/j.xplc.2024.101181</a>.","apa":"Wei, H., Zhu, H., Ying, W., Janssens, H., Kvasnica, M., Winne, J., … Sun, L. (2025). Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1. <i>Plant Communications</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.xplc.2024.101181\">https://doi.org/10.1016/j.xplc.2024.101181</a>","short":"H. Wei, H. Zhu, W. Ying, H. Janssens, M. Kvasnica, J. Winne, Y. Gao, J. Friml, Q. Ma, S. Tan, X. Liu, E. Russinova, L. Sun, Plant Communications 6 (2025).","ieee":"H. Wei <i>et al.</i>, “Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1,” <i>Plant Communications</i>, vol. 6, no. 1. Cell Press, 2025."},"publication_status":"published","OA_place":"publisher","OA_type":"gold","doi":"10.1016/j.xplc.2024.101181","file_date_updated":"2025-04-16T09:02:05Z","intvolume":"         6","oa_version":"Published Version","publication":"Plant Communications","isi":1,"file":[{"creator":"dernst","file_name":"2025_PlantComm_Wei.pdf","success":1,"date_updated":"2025-04-16T09:02:05Z","file_id":"19575","access_level":"open_access","date_created":"2025-04-16T09:02:05Z","content_type":"application/pdf","checksum":"7b0e4511e43cc0da06730c3edb7c1167","file_size":4443183,"relation":"main_file"}],"date_updated":"2026-10-20T08:56:15Z","oa":1,"das_tickbox":"1","department":[{"_id":"JiFr"}],"article_type":"original","date_created":"2024-12-04T11:21:16Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","dataavailabilitystatement":"The ABCB1 structures in the substrate-unbound state, BL-bound state, and ATP plus BL-bound state have been deposited in the Protein Data Bank under accession codes 8ZPX, 8ZPZ, and 8ZQ4, respectively. The corresponding cryo-EM density maps have been deposited in the Electron Microscopy Data Bank under accession codes EMD-60366, EMD-60369, and EMD-60370, respectively.","month":"01","_id":"18619","DOAJ_listed":"1","day":"13","article_processing_charge":"Yes","type":"journal_article","supplementarymaterial":"yes","article_number":"101181","author":[{"full_name":"Wei, H","first_name":"H","last_name":"Wei"},{"full_name":"Zhu, H","first_name":"H","last_name":"Zhu"},{"first_name":"W","full_name":"Ying, W","last_name":"Ying"},{"first_name":"H","full_name":"Janssens, H","last_name":"Janssens"},{"last_name":"Kvasnica","first_name":"M","full_name":"Kvasnica, M"},{"first_name":"JM","full_name":"Winne, JM","last_name":"Winne"},{"last_name":"Gao","full_name":"Gao, Y","first_name":"Y"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří"},{"last_name":"Ma","first_name":"Q","full_name":"Ma, Q"},{"first_name":"S","full_name":"Tan, S","last_name":"Tan"},{"full_name":"Liu, X","first_name":"X","last_name":"Liu"},{"last_name":"Russinova","full_name":"Russinova, E","first_name":"E"},{"full_name":"Sun, L","first_name":"L","last_name":"Sun"}],"publication_identifier":{"issn":["2590-3462"]},"scopus_import":"1","date_published":"2025-01-13T00:00:00Z","pmid":1,"external_id":{"pmid":["39497419"],"isi":["001416757300001"]},"language":[{"iso":"eng"}],"ddc":["580"],"fulldoi":"https://doi.org/10.1016/j.xplc.2024.101181","has_accepted_license":"1"},{"year":"2025","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":37,"OA_place":"publisher","publication_status":"published","citation":{"ista":"Gallei MC, Truckenbrodt SM, Kreuzinger C, Inumella S, Vistunou V, Sommer CM, Tavakoli M, Agudelo Duenas N, Vorlaufer J, Jahr W, Randuch M, Johnson AJ, Benková E, Friml J, Danzl JG. 2025. Super-resolution expansion microscopy in plant roots. The Plant Cell. 37(4), koaf006.","ama":"Gallei MC, Truckenbrodt SM, Kreuzinger C, et al. Super-resolution expansion microscopy in plant roots. <i>The Plant Cell</i>. 2025;37(4). doi:<a href=\"https://doi.org/10.1093/plcell/koaf006\">10.1093/plcell/koaf006</a>","mla":"Gallei, Michelle C., et al. “Super-Resolution Expansion Microscopy in Plant Roots.” <i>The Plant Cell</i>, vol. 37, no. 4, koaf006, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/plcell/koaf006\">10.1093/plcell/koaf006</a>.","chicago":"Gallei, Michelle C, Sven M Truckenbrodt, Caroline Kreuzinger, Syamala Inumella, Vitali Vistunou, Christoph M Sommer, Mojtaba Tavakoli, et al. “Super-Resolution Expansion Microscopy in Plant Roots.” <i>The Plant Cell</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/plcell/koaf006\">https://doi.org/10.1093/plcell/koaf006</a>.","apa":"Gallei, M. C., Truckenbrodt, S. M., Kreuzinger, C., Inumella, S., Vistunou, V., Sommer, C. M., … Danzl, J. G. (2025). Super-resolution expansion microscopy in plant roots. <i>The Plant Cell</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/plcell/koaf006\">https://doi.org/10.1093/plcell/koaf006</a>","short":"M.C. Gallei, S.M. Truckenbrodt, C. Kreuzinger, S. Inumella, V. Vistunou, C.M. Sommer, M. Tavakoli, N. Agudelo Duenas, J. Vorlaufer, W. Jahr, M. Randuch, A.J. Johnson, E. Benková, J. Friml, J.G. Danzl, The Plant Cell 37 (2025).","ieee":"M. C. Gallei <i>et al.</i>, “Super-resolution expansion microscopy in plant roots,” <i>The Plant Cell</i>, vol. 37, no. 4. Oxford University Press, 2025."},"OA_type":"hybrid","doi":"10.1093/plcell/koaf006","publisher":"Oxford University Press","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"},{"call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program"},{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"name":"UltraX - achieving sub-nanometer resolution in light microscopy using iterative X10 microscopy in combination with nanobodies and STED","grant_number":"ALTF 679-2018","_id":"269B5B22-B435-11E9-9278-68D0E5697425"},{"name":"Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy","_id":"6285a163-2b32-11ec-9570-8e204ca2dba5","grant_number":"26137"},{"name":"Molecular Drug Targets","call_identifier":"FWF","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425","grant_number":"W1232-B24"}],"status":"public","issue":"4","quality_controlled":"1","abstract":[{"lang":"eng","text":"Super-resolution methods provide far better spatial resolution than the optical diffraction limit of about half the wavelength of light (∼200-300 nm). Nevertheless, they have yet to attain widespread use in plants, largely due to plants’ challenging optical properties. Expansion microscopy improves effective resolution by isotropically increasing the physical distances between sample structures while preserving relative spatial arrangements and clearing the sample. However, its application to plants has been hindered by the rigid, mechanically cohesive structure of plant tissues. Here, we report on whole-mount expansion microscopy of thale cress (Arabidopsis thaliana) root tissues (PlantEx), achieving a four-fold resolution increase over conventional microscopy. Our results highlight the microtubule cytoskeleton organization and interaction between molecularly defined cellular constituents. Combining PlantEx with stimulated emission depletion (STED) microscopy, we increase nanoscale resolution and visualize the complex organization of subcellular organelles from intact tissues by example of the densely packed COPI-coated vesicles associated with the Golgi apparatus and put these into a cellular structural context. Our results show that expansion microscopy can be applied to increase effective imaging resolution in Arabidopsis root specimens. "}],"title":"Super-resolution expansion microscopy in plant roots","acknowledgement":"We gratefully acknowledge support by the Scientific Service Units at ISTA, including the Imaging and Optics and Lab Support facilities and the mechanical workshop and Library. We thank Philipp Velicky for STED microscope alignment.\r\nThis project has received funding from the European Research Council under the Horizon 2020 Framework Programme (grant agreement No 742985, J.F.). It has also received funding from the Horizon 2020 Framework Programme under the Marie Skłodowska-Curie Grant Agreement No. 665385 (M.G.). S.T. has received funding as an ISTplus Fellow from the Horizon 2020 Framework Programme under Marie Skłodowska-Curie grant agreement no. 754411 and from EMBO via a Long-Term Fellowship (grant number ALTF 679-2018). M.R.T. received funding from the Austrian Academy of Sciences with DOC fellowship no. 26137. The project has further received funding from the Austrian Science Fund, via grant DK W1232 (M.R.T., N.A.D., and J.G.D). W.J. received a postdoctoral fellowship from the Human Frontier Science Program (LT000557/2018). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.","article_type":"original","department":[{"_id":"EvBe"},{"_id":"JoDa"},{"_id":"JiFr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-02-05T06:52:06Z","month":"04","ec_funded":1,"_id":"19003","intvolume":"        37","file_date_updated":"2025-07-31T07:03:43Z","publication":"The Plant Cell","oa_version":"Published Version","oa":1,"isi":1,"file":[{"content_type":"application/pdf","date_created":"2025-07-31T07:03:43Z","access_level":"open_access","relation":"main_file","file_size":53904111,"checksum":"9d3f8218ff37a29f29c48a7bbe831bd3","creator":"dernst","file_name":"2025_PlantCell_Gallei.pdf","date_updated":"2025-07-31T07:03:43Z","file_id":"20092","success":1}],"date_updated":"2026-10-20T09:19:12Z","related_material":{"record":[{"relation":"research_data","id":"18837","status":"public"},{"id":"18689","status":"public","relation":"earlier_version"}]},"article_number":"koaf006","corr_author":"1","author":[{"last_name":"Gallei","orcid":"0000-0003-1286-7368","full_name":"Gallei, Michelle C","first_name":"Michelle C","id":"35A03822-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Truckenbrodt","id":"45812BD4-F248-11E8-B48F-1D18A9856A87","first_name":"Sven M","full_name":"Truckenbrodt, Sven M"},{"full_name":"Kreuzinger, Caroline","first_name":"Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kreuzinger"},{"last_name":"Inumella","orcid":"0009-0002-5890-120X","id":"F8660870-D756-11E9-98C5-34DFE5697425","first_name":"Syamala","full_name":"Inumella, Syamala"},{"full_name":"Vistunou, Vitali","first_name":"Vitali","id":"7e146587-8972-11ed-ae7b-d7a32ea86a81","last_name":"Vistunou"},{"first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","full_name":"Sommer, Christoph M","last_name":"Sommer","orcid":"0000-0003-1216-9105"},{"full_name":"Tavakoli, Mojtaba","first_name":"Mojtaba","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87","last_name":"Tavakoli","orcid":"0000-0002-7667-6854"},{"full_name":"Agudelo Duenas, Nathalie","first_name":"Nathalie","id":"40E7F008-F248-11E8-B48F-1D18A9856A87","last_name":"Agudelo Duenas"},{"orcid":"0009-0000-7590-3501","last_name":"Vorlaufer","first_name":"Jakob","id":"937696FA-C996-11E9-8C7C-CF13E6697425","full_name":"Vorlaufer, Jakob"},{"id":"425C1CE8-F248-11E8-B48F-1D18A9856A87","first_name":"Wiebke","full_name":"Jahr, Wiebke","last_name":"Jahr","orcid":"0000-0003-0201-2315"},{"last_name":"Randuch","full_name":"Randuch, Marek","first_name":"Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae"},{"last_name":"Johnson","orcid":"0000-0002-2739-8843","first_name":"Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","full_name":"Johnson, Alexander J"},{"full_name":"Benková, Eva","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","orcid":"0000-0002-8510-9739"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","full_name":"Friml, Jiří"},{"last_name":"Danzl","orcid":"0000-0001-8559-3973","first_name":"Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G"}],"publication_identifier":{"issn":["1040-4651"],"eissn":["1532-298X"]},"scopus_import":"1","day":"01","article_processing_charge":"Yes (via OA deal)","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"E-Lib"},{"_id":"M-Shop"}],"PlanS_conform":"1","type":"journal_article","fulldoi":"https://doi.org/10.1093/plcell/koaf006","ddc":["580"],"has_accepted_license":"1","external_id":{"isi":["001462763100001"],"pmid":["39792900"]},"date_published":"2025-04-01T00:00:00Z","pmid":1,"language":[{"iso":"eng"}]},{"has_accepted_license":"1","fulldoi":"https://doi.org/10.1038/s41467-025-63852-x","ddc":["000"],"date_published":"2025-10-01T00:00:00Z","external_id":{"pmid":["41034200"],"isi":["001586620700015"]},"pmid":1,"language":[{"iso":"eng"}],"article_number":"8763","corr_author":"1","supplementarymaterial":"no","publication_identifier":{"eissn":["2041-1723"]},"scopus_import":"1","author":[{"first_name":"Daniel S.","full_name":"King, Daniel S.","last_name":"King"},{"last_name":"Kim","first_name":"Dongjin","full_name":"Kim, Dongjin"},{"last_name":"Zhong","full_name":"Zhong, Peichen","first_name":"Peichen"},{"first_name":"Bingqing","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","full_name":"Cheng, Bingqing","last_name":"Cheng","orcid":"0000-0002-3584-9632"}],"day":"01","type":"journal_article","article_processing_charge":"Yes","PlanS_conform":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-10-12T22:01:25Z","article_type":"original","department":[{"_id":"BiCh"}],"DOAJ_listed":"1","_id":"20452","month":"10","dataavailabilitystatement":"The training sets, training scripts, MD input files, and trained CACE potentials are available at https://github.com/BingqingCheng/cace-lr-fit; see https://doi.org/10.5281/zenodo.16415061. Source data for all figures are provided with this paper. Source data are provided with this paper.","publication":"Nature Communications","oa_version":"Published Version","intvolume":"        16","file_date_updated":"2025-10-13T07:54:51Z","related_material":{"record":[{"relation":"research_data","status":"public","id":"22770"}]},"das_tickbox":"1","oa":1,"date_updated":"2026-10-20T09:48:07Z","isi":1,"file":[{"date_updated":"2025-10-13T07:54:51Z","file_id":"20460","success":1,"creator":"dernst","file_name":"2025_NatureComm_King.pdf","relation":"main_file","checksum":"34b6005d349bbff85839c4e51d6c8725","file_size":4907055,"content_type":"application/pdf","date_created":"2025-10-13T07:54:51Z","access_level":"open_access"}],"citation":{"chicago":"King, Daniel S., Dongjin Kim, Peichen Zhong, and Bingqing Cheng. “Machine Learning of Charges and Long-Range Interactions from Energies and Forces.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-63852-x\">https://doi.org/10.1038/s41467-025-63852-x</a>.","apa":"King, D. S., Kim, D., Zhong, P., &#38; Cheng, B. (2025). Machine learning of charges and long-range interactions from energies and forces. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-63852-x\">https://doi.org/10.1038/s41467-025-63852-x</a>","short":"D.S. King, D. Kim, P. Zhong, B. Cheng, Nature Communications 16 (2025).","ieee":"D. S. King, D. Kim, P. Zhong, and B. Cheng, “Machine learning of charges and long-range interactions from energies and forces,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ista":"King DS, Kim D, Zhong P, Cheng B. 2025. Machine learning of charges and long-range interactions from energies and forces. Nature Communications. 16, 8763.","ama":"King DS, Kim D, Zhong P, Cheng B. Machine learning of charges and long-range interactions from energies and forces. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-63852-x\">10.1038/s41467-025-63852-x</a>","mla":"King, Daniel S., et al. “Machine Learning of Charges and Long-Range Interactions from Energies and Forces.” <i>Nature Communications</i>, vol. 16, 8763, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-63852-x\">10.1038/s41467-025-63852-x</a>."},"OA_place":"publisher","publication_status":"published","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":16,"researchdata_availability":"no","year":"2025","doi":"10.1038/s41467-025-63852-x","OA_type":"gold","quality_controlled":"1","publisher":"Springer Nature","status":"public","acknowledgement":"We thank Chunyi Zhang for providing the TiO2(101)/NaCl+NaOH+HCl(aq) dataset and for useful discussions. We thank Jia-Xin Zhu for providing the Pt(111)/KF(aq) dataset. We thank Tsz Wai Ko and Jonas Finkler for useful discussions and for the DFT-optimized Au2-MgO(001) structures. We thank Junmin Chen for discussions. D.K and B.C. acknowledge funding from Toyota Research Institute Synthesis Advanced Research Challenge. D.S.K. and P.Z. acknowledge funding from BIDMaP Postdoctoral Fellowship.","title":"Machine learning of charges and long-range interactions from energies and forces","abstract":[{"lang":"eng","text":"Accurate modeling of long-range forces is critical in atomistic simulations, as they play a central role in determining the properties of material and chemical systems. However, standard machine learning interatomic potentials (MLIPs) often rely on short-range approximations, limiting their applicability to systems with significant electrostatics and dispersion forces. We recently introduced the Latent Ewald Summation (LES) method, which captures long-range electrostatics without explicitly learning atomic charges or charge equilibration. We benchmark LES on diverse and challenging systems, including charged molecules, ionic liquids, electrolyte solutions, polar dipeptides, surface adsorption, electrolyte/solid interfaces, and solid-solid interfaces. Here we show that LES can reproduce the exact atomic charges for classical systems with fixed charges and can infer dipole and quadrupole moments, as well as the dipole derivative with respect to atomic positions, for quantum mechanical systems. Moreover, LES can achieve better accuracy in energy and force predictions compared to methods that explicitly learn from charges."}]},{"article_processing_charge":"No","title":"BingqingCheng/cace-lr-fit: V0","type":"research_data_reference","day":"24","publisher":"Zenodo","status":"public","OA_type":"green","author":[{"full_name":"Cheng, Bingqing","first_name":"Bingqing","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","last_name":"Cheng","orcid":"0000-0002-3584-9632"},{"last_name":"King","full_name":"King, Daniel","first_name":"Daniel"},{"full_name":"Kim, Dongjin","first_name":"Dongjin","last_name":"Kim"},{"first_name":"Peichen","full_name":"Zhong, Peichen","last_name":"Zhong"}],"doi":"10.5281/zenodo.16415060","main_file_link":[{"url":"https://doi.org/10.5281/zenodo.16415061","open_access":"1"}],"year":"2025","citation":{"ista":"Cheng B, King D, Kim D, Zhong P. 2025. BingqingCheng/cace-lr-fit: V0, Zenodo, <a href=\"https://doi.org/10.5281/zenodo.16415060\">10.5281/zenodo.16415060</a>.","mla":"Cheng, Bingqing, et al. <i>BingqingCheng/Cace-Lr-Fit: V0</i>. Zenodo, 2025, doi:<a href=\"https://doi.org/10.5281/zenodo.16415060\">10.5281/zenodo.16415060</a>.","ama":"Cheng B, King D, Kim D, Zhong P. BingqingCheng/cace-lr-fit: V0. 2025. doi:<a href=\"https://doi.org/10.5281/zenodo.16415060\">10.5281/zenodo.16415060</a>","apa":"Cheng, B., King, D., Kim, D., &#38; Zhong, P. (2025). BingqingCheng/cace-lr-fit: V0. Zenodo. <a href=\"https://doi.org/10.5281/zenodo.16415060\">https://doi.org/10.5281/zenodo.16415060</a>","chicago":"Cheng, Bingqing, Daniel King, Dongjin Kim, and Peichen Zhong. “BingqingCheng/Cace-Lr-Fit: V0.” Zenodo, 2025. <a href=\"https://doi.org/10.5281/zenodo.16415060\">https://doi.org/10.5281/zenodo.16415060</a>.","ieee":"B. Cheng, D. King, D. Kim, and P. Zhong, “BingqingCheng/cace-lr-fit: V0.” Zenodo, 2025.","short":"B. Cheng, D. King, D. Kim, P. Zhong, (2025)."},"OA_place":"repository","oa":1,"date_updated":"2026-10-20T09:48:08Z","related_material":{"record":[{"id":"20452","status":"public","relation":"used_in_publication"}]},"date_published":"2025-07-24T00:00:00Z","oa_version":"None","fulldoi":"https://doi.org/10.5281/zenodo.16415060","month":"07","ddc":["000"],"_id":"22770","department":[{"_id":"BiCh"}],"date_created":"2026-08-27T12:13:55Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"article_type":"original","department":[{"_id":"MiLe"},{"_id":"MaSe"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-12-29T23:01:58Z","month":"01","dataavailabilitystatement":"Data for this article, including potential energy curves, Auger decay rates and spectral lines, are available at ZENODO at https://doi.org/10.5281/zenodo.13833475.","_id":"18710","ec_funded":1,"intvolume":"        27","file_date_updated":"2025-04-16T09:46:45Z","oa_version":"Published Version","publication":"Physical Chemistry Chemical Physics","oa":1,"isi":1,"date_updated":"2026-10-21T07:56:55Z","file":[{"creator":"dernst","file_name":"2025_PCCP_Hrast.pdf","file_id":"19581","date_updated":"2025-04-16T09:46:45Z","success":1,"access_level":"open_access","content_type":"application/pdf","date_created":"2025-04-16T09:46:45Z","file_size":1270582,"checksum":"d035683179547b41b811107a8649aab0","relation":"main_file"}],"related_material":{"record":[{"relation":"research_data","id":"18716","status":"public"},{"id":"22866","status":"public","relation":"research_data"}]},"das_tickbox":"1","year":"2025","tmp":{"short":"CC BY-NC (3.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)"},"researchdata_availability":"yes","volume":27,"citation":{"ista":"Hrast M, Ljubotina M, Zitnik M. 2025. Ab initio Auger spectrum of the ultrafast dissociating 2p3/2−1σ* resonance in HCl. Physical Chemistry Chemical Physics. 27(3), 1473–1482.","ama":"Hrast M, Ljubotina M, Zitnik M. Ab initio Auger spectrum of the ultrafast dissociating 2p3/2−1σ* resonance in HCl. <i>Physical Chemistry Chemical Physics</i>. 2025;27(3):1473-1482. doi:<a href=\"https://doi.org/10.1039/d4cp03727h\">10.1039/d4cp03727h</a>","mla":"Hrast, Mateja, et al. “Ab Initio Auger Spectrum of the Ultrafast Dissociating 2p3/2−1σ* Resonance in HCl.” <i>Physical Chemistry Chemical Physics</i>, vol. 27, no. 3, Royal Society of Chemistry, 2025, pp. 1473–82, doi:<a href=\"https://doi.org/10.1039/d4cp03727h\">10.1039/d4cp03727h</a>.","chicago":"Hrast, Mateja, Marko Ljubotina, and Matjaz Zitnik. “Ab Initio Auger Spectrum of the Ultrafast Dissociating 2p3/2−1σ* Resonance in HCl.” <i>Physical Chemistry Chemical Physics</i>. Royal Society of Chemistry, 2025. <a href=\"https://doi.org/10.1039/d4cp03727h\">https://doi.org/10.1039/d4cp03727h</a>.","apa":"Hrast, M., Ljubotina, M., &#38; Zitnik, M. (2025). Ab initio Auger spectrum of the ultrafast dissociating 2p3/2−1σ* resonance in HCl. <i>Physical Chemistry Chemical Physics</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d4cp03727h\">https://doi.org/10.1039/d4cp03727h</a>","short":"M. Hrast, M. Ljubotina, M. Zitnik, Physical Chemistry Chemical Physics 27 (2025) 1473–1482.","ieee":"M. Hrast, M. Ljubotina, and M. Zitnik, “Ab initio Auger spectrum of the ultrafast dissociating 2p3/2−1σ* resonance in HCl,” <i>Physical Chemistry Chemical Physics</i>, vol. 27, no. 3. Royal Society of Chemistry, pp. 1473–1482, 2025."},"publication_status":"published","OA_place":"publisher","OA_type":"hybrid","doi":"10.1039/d4cp03727h","publisher":"Royal Society of Chemistry","project":[{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770","call_identifier":"H2020","name":"Angulon: physics and applications of a new quasiparticle"}],"issue":"3","status":"public","license":"https://creativecommons.org/licenses/by-nc/3.0/","quality_controlled":"1","title":"Ab initio Auger spectrum of the ultrafast dissociating 2p3/2−1σ* resonance in HCl","abstract":[{"text":"We present an ab initio theoretical method to calculate the resonant Auger spectrum in the presence of ultrafast dissociation. The method is demonstrated by deriving the L-VV resonant Auger spectrum mediated by the 2p3/2−1σ* resonance in HCl, where the electronic Auger decay and nuclear dissociation occur on the same time scale. The Auger decay rates are calculated within the one-center approximation and are shown to vary significantly with the inter-nuclear distance. A quantum-mechanical description of dissociation is effectuated by propagating the corresponding Franck–Condon factors. The calculated profiles of Auger spectral lines resemble those of atomic Auger decay but here the characteristic tails extend towards lower electron kinetic energies, which reflect specific features of the potential energy curves. The presented method can describe the resonant Auger spectrum for an arbitrary speed of dissociation and simplifies to known approximations in the limiting cases.","lang":"eng"}],"acknowledgement":"This publication is based upon work from COST Action CA18212 – Molecular Dynamics in the GAS phase (MD-GAS), supported by COST (European Cooperation in Science and Technology). This work was financially supported by the Slovenian Research Agency in the framework of research program P1-0112 Studies of Atoms, Molecules and Structures by Photons and Particles. Part of this work was financed by the European Research Council (ERC) through the Starting Grant No. 801770 (ANGULON). The authors acknowledge P. Lablanquie, H. Iwayama, F. Penent, K. Soejima and E. Shigemasa for sharing their unpublished experimental spectra on HCl.","fulldoi":"https://doi.org/10.1039/d4cp03727h","ddc":["530"],"has_accepted_license":"1","pmid":1,"date_published":"2025-01-21T00:00:00Z","external_id":{"isi":["001379819100001"],"pmid":["39698879"]},"language":[{"iso":"eng"}],"supplementarymaterial":"no","corr_author":"1","page":"1473-1482","author":[{"last_name":"Hrast","id":"48dbb294-2a9c-11ef-905d-f56be71f0e5d","first_name":"Mateja","full_name":"Hrast, Mateja"},{"id":"F75EE9BE-5C90-11EA-905D-16643DDC885E","first_name":"Marko","full_name":"Ljubotina, Marko","last_name":"Ljubotina","orcid":"0000-0003-0038-7068"},{"first_name":"Matjaz","full_name":"Zitnik, Matjaz","last_name":"Zitnik"}],"scopus_import":"1","publication_identifier":{"issn":["1463-9076"]},"day":"21","article_processing_charge":"Yes (via OA deal)","type":"journal_article"},{"article_processing_charge":"Yes (in subscription journal)","type":"journal_article","day":"01","author":[{"first_name":"Yi","full_name":"Pan, Yi","last_name":"Pan"},{"full_name":"Hochgerner, Mathias","first_name":"Mathias","last_name":"Hochgerner"},{"id":"d63197a3-c188-11ed-9387-8d33a3f13871","first_name":"Malgorzata Anna","full_name":"Cichon, Malgorzata Anna","last_name":"Cichon"},{"last_name":"Benezeder","first_name":"Theresa","full_name":"Benezeder, Theresa"},{"first_name":"Thomas","full_name":"Bieber, Thomas","last_name":"Bieber"},{"full_name":"Wolf, Peter","first_name":"Peter","last_name":"Wolf"}],"publication_identifier":{"eissn":["1468-3083"],"issn":["0926-9959"]},"scopus_import":"1","supplementarymaterial":"no","page":"278-289","language":[{"iso":"eng"}],"pmid":1,"external_id":{"isi":["001292894900001"],"pmid":["39157943"]},"date_published":"2025-02-01T00:00:00Z","fulldoi":"https://doi.org/10.1111/jdv.20291","ddc":["570"],"has_accepted_license":"1","abstract":[{"lang":"eng","text":"Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide. AD is a highly complex disease with different subtypes. Many elements of AD pathophysiology have been described, but if/how they interact with each other or which mechanisms are important in which patients is still unclear. Langerhans cells (LCs) are antigen-presenting cells (APCs) in the epidermis. Depending on the context, they can act either pro- or anti-inflammatory. Many different studies have investigated LCs in the context of AD and found them to be connected to all major mechanisms of AD pathophysiology. As APCs, LCs recruit other immune cells and shape the immune response, especially adaptive immunity via polarization of T cells. As sentinel cells, LCs are primary sensors of the skin microbiome and are important for the decision of immunity versus tolerance. LCs are also involved with the integrity of the skin barrier by influencing tight junctions. Finally, LCs are important cells in the neuro-immune crosstalk in the skin. In this review, we provide an overview about the many different roles of LCs in AD. Understanding LCs might bring us closer to a more complete understanding of this highly complex disease. Potentially, modulating LCs might offer new options for targeted therapies for AD patients."}],"title":"Langerhans cells: Central players in the pathophysiology of atopic dermatitis","acknowledgement":"This work was supported by the CK-CARE of the KühneFoundation, Switzerland; the China Scholarship Counciland Shanghai Biocelline Enterprise Co. Ltd, China.","publisher":"Wiley","issue":"2","status":"public","quality_controlled":"1","OA_type":"hybrid","doi":"10.1111/jdv.20291","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":39,"researchdata_availability":"not applicable","year":"2025","citation":{"ieee":"Y. Pan, M. Hochgerner, M. A. Cichon, T. Benezeder, T. Bieber, and P. Wolf, “Langerhans cells: Central players in the pathophysiology of atopic dermatitis,” <i>Journal of the European Academy of Dermatology and Venereology</i>, vol. 39, no. 2. Wiley, pp. 278–289, 2025.","short":"Y. Pan, M. Hochgerner, M.A. Cichon, T. Benezeder, T. Bieber, P. Wolf, Journal of the European Academy of Dermatology and Venereology 39 (2025) 278–289.","apa":"Pan, Y., Hochgerner, M., Cichon, M. A., Benezeder, T., Bieber, T., &#38; Wolf, P. (2025). Langerhans cells: Central players in the pathophysiology of atopic dermatitis. <i>Journal of the European Academy of Dermatology and Venereology</i>. Wiley. <a href=\"https://doi.org/10.1111/jdv.20291\">https://doi.org/10.1111/jdv.20291</a>","chicago":"Pan, Yi, Mathias Hochgerner, Malgorzata Anna Cichon, Theresa Benezeder, Thomas Bieber, and Peter Wolf. “Langerhans Cells: Central Players in the Pathophysiology of Atopic Dermatitis.” <i>Journal of the European Academy of Dermatology and Venereology</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/jdv.20291\">https://doi.org/10.1111/jdv.20291</a>.","mla":"Pan, Yi, et al. “Langerhans Cells: Central Players in the Pathophysiology of Atopic Dermatitis.” <i>Journal of the European Academy of Dermatology and Venereology</i>, vol. 39, no. 2, Wiley, 2025, pp. 278–89, doi:<a href=\"https://doi.org/10.1111/jdv.20291\">10.1111/jdv.20291</a>.","ama":"Pan Y, Hochgerner M, Cichon MA, Benezeder T, Bieber T, Wolf P. Langerhans cells: Central players in the pathophysiology of atopic dermatitis. <i>Journal of the European Academy of Dermatology and Venereology</i>. 2025;39(2):278-289. doi:<a href=\"https://doi.org/10.1111/jdv.20291\">10.1111/jdv.20291</a>","ista":"Pan Y, Hochgerner M, Cichon MA, Benezeder T, Bieber T, Wolf P. 2025. Langerhans cells: Central players in the pathophysiology of atopic dermatitis. Journal of the European Academy of Dermatology and Venereology. 39(2), 278–289."},"publication_status":"published","OA_place":"publisher","oa":1,"date_updated":"2026-10-21T07:59:34Z","isi":1,"file":[{"success":1,"file_id":"19583","date_updated":"2025-04-16T09:59:37Z","creator":"dernst","file_name":"2025_JEADV_Pan.pdf","relation":"main_file","file_size":457698,"checksum":"12555ddb3490daf10b8d44e334e7312e","date_created":"2025-04-16T09:59:37Z","content_type":"application/pdf","access_level":"open_access"}],"das_tickbox":"1","intvolume":"        39","file_date_updated":"2025-04-16T09:59:37Z","publication":"Journal of the European Academy of Dermatology and Venereology","oa_version":"Published Version","month":"02","dataavailabilitystatement":"Data sharing not applicable to this article as no data sets were generated or analysed during the review.","_id":"17459","article_type":"original","department":[{"_id":"MiSi"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-08-25T22:01:07Z"},{"fulldoi":"https://doi.org/10.1007/s10107-024-02066-3","language":[{"iso":"eng"}],"date_published":"2025-03-01T00:00:00Z","external_id":{"isi":["001176048100003"],"arxiv":["2301.09217"]},"arxiv":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2301.09217","open_access":"1"}],"scopus_import":"1","publication_identifier":{"eissn":["1436-4646"],"issn":["0025-5610"]},"author":[{"last_name":"Zheng","first_name":"Da Wei","full_name":"Zheng, Da Wei"},{"full_name":"Henzinger, Monika H","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","last_name":"Henzinger"}],"page":"881-894","corr_author":"1","supplementarymaterial":"no","type":"journal_article","article_processing_charge":"No","day":"01","ec_funded":1,"_id":"15121","month":"03","date_created":"2024-03-17T23:00:58Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"MoHe"}],"article_type":"original","das_tickbox":"0","related_material":{"record":[{"relation":"earlier_version","id":"13236","status":"public"}]},"isi":1,"date_updated":"2026-10-21T08:03:01Z","oa":1,"oa_version":"Preprint","publication":"Mathematical Programming","intvolume":"       210","doi":"10.1007/s10107-024-02066-3","OA_type":"green","publication_status":"published","citation":{"ista":"Zheng DW, Henzinger M. 2025. Multiplicative auction algorithm for approximate maximum weight bipartite matching. Mathematical Programming. 210, 881–894.","ama":"Zheng DW, Henzinger M. Multiplicative auction algorithm for approximate maximum weight bipartite matching. <i>Mathematical Programming</i>. 2025;210:881-894. doi:<a href=\"https://doi.org/10.1007/s10107-024-02066-3\">10.1007/s10107-024-02066-3</a>","mla":"Zheng, Da Wei, and Monika Henzinger. “Multiplicative Auction Algorithm for Approximate Maximum Weight Bipartite Matching.” <i>Mathematical Programming</i>, vol. 210, Springer Nature, 2025, pp. 881–94, doi:<a href=\"https://doi.org/10.1007/s10107-024-02066-3\">10.1007/s10107-024-02066-3</a>.","chicago":"Zheng, Da Wei, and Monika Henzinger. “Multiplicative Auction Algorithm for Approximate Maximum Weight Bipartite Matching.” <i>Mathematical Programming</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s10107-024-02066-3\">https://doi.org/10.1007/s10107-024-02066-3</a>.","apa":"Zheng, D. W., &#38; Henzinger, M. (2025). Multiplicative auction algorithm for approximate maximum weight bipartite matching. <i>Mathematical Programming</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10107-024-02066-3\">https://doi.org/10.1007/s10107-024-02066-3</a>","short":"D.W. Zheng, M. Henzinger, Mathematical Programming 210 (2025) 881–894.","ieee":"D. W. Zheng and M. Henzinger, “Multiplicative auction algorithm for approximate maximum weight bipartite matching,” <i>Mathematical Programming</i>, vol. 210. Springer Nature, pp. 881–894, 2025."},"OA_place":"repository","volume":210,"year":"2025","researchdata_availability":"no","acknowledgement":"The first author thanks Chandra Chekuri for useful discussions about this paper. This work was done in part at the University of Vienna. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101019564 “The Design of Modern Fully Dynamic Data Structures (MoDynStruct)” and from the Austrian Science Fund (FWF) project “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P 33775-N, with additional funding from the netidee SCIENCE Stiftung, 2020–2024.","abstract":[{"lang":"eng","text":"We present an auction algorithm using multiplicative instead of constant weight updates to compute a (1-E)-approximate maximum weight matching (MWM) in a bipartite graph with n vertices and m edges in time 0(mE-1), beating the running time of the fastest known approximation algorithm of Duan and Pettie [JACM ’14] that runs in 0(mE-1 log E-1). Our algorithm is very simple and it can be extended to give a dynamic data structure that maintains a (1-E)-approximate maximum weight matching under (1) one-sided vertex deletions (with incident edges) and (2) one-sided vertex insertions (with incident edges sorted by weight) to the other side. The total time time used is 0(mE-1), where m is the sum of the number of initially existing and inserted edges."}],"title":"Multiplicative auction algorithm for approximate maximum weight bipartite matching","quality_controlled":"1","status":"public","project":[{"grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","call_identifier":"H2020","name":"The design and evaluation of modern fully dynamic data structures"},{"_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","grant_number":"P33775","name":"Fast Algorithms for a Reactive Network Layer"}],"publisher":"Springer Nature"},{"OA_place":"publisher","publication_status":"published","citation":{"short":"A. Martín‐Belmonte, C. Aguado, R. Alfaro‐Ruiz, A. Kulik, L. de la Ossa, A.E. Moreno‐Martínez, S. Alberquilla, L. García‐Carracedo, M. Fernández, A. Fajardo‐Serrano, E. Aso, R. Shigemoto, E.D. Martín, Y. Fukazawa, F. Ciruela, R. Luján, Brain Pathology 35 (2025).","ieee":"A. Martín‐Belmonte <i>et al.</i>, “Nanoarchitecture of CaV&#62;2.1 channels and GABAB receptors in the mouse hippocampus: Impact of APP/PS1 pathology,” <i>Brain Pathology</i>, vol. 35, no. 2. Wiley, 2025.","chicago":"Martín‐Belmonte, Alejandro, Carolina Aguado, Rocío Alfaro‐Ruiz, Akos Kulik, Luis de la Ossa, Ana Esther Moreno‐Martínez, Samuel Alberquilla, et al. “Nanoarchitecture of CaV&#62;2.1 Channels and GABAB Receptors in the Mouse Hippocampus: Impact of APP/PS1 Pathology.” <i>Brain Pathology</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/bpa.13279\">https://doi.org/10.1111/bpa.13279</a>.","apa":"Martín‐Belmonte, A., Aguado, C., Alfaro‐Ruiz, R., Kulik, A., de la Ossa, L., Moreno‐Martínez, A. E., … Luján, R. (2025). Nanoarchitecture of CaV&#62;2.1 channels and GABAB receptors in the mouse hippocampus: Impact of APP/PS1 pathology. <i>Brain Pathology</i>. Wiley. <a href=\"https://doi.org/10.1111/bpa.13279\">https://doi.org/10.1111/bpa.13279</a>","ama":"Martín‐Belmonte A, Aguado C, Alfaro‐Ruiz R, et al. Nanoarchitecture of CaV&#62;2.1 channels and GABAB receptors in the mouse hippocampus: Impact of APP/PS1 pathology. <i>Brain Pathology</i>. 2025;35(2). doi:<a href=\"https://doi.org/10.1111/bpa.13279\">10.1111/bpa.13279</a>","mla":"Martín‐Belmonte, Alejandro, et al. “Nanoarchitecture of CaV&#62;2.1 Channels and GABAB Receptors in the Mouse Hippocampus: Impact of APP/PS1 Pathology.” <i>Brain Pathology</i>, vol. 35, no. 2, e13279, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/bpa.13279\">10.1111/bpa.13279</a>.","ista":"Martín‐Belmonte A, Aguado C, Alfaro‐Ruiz R, Kulik A, de la Ossa L, Moreno‐Martínez AE, Alberquilla S, García‐Carracedo L, Fernández M, Fajardo‐Serrano A, Aso E, Shigemoto R, Martín ED, Fukazawa Y, Ciruela F, Luján R. 2025. Nanoarchitecture of CaV&#62;2.1 channels and GABAB receptors in the mouse hippocampus: Impact of APP/PS1 pathology. Brain Pathology. 35(2), e13279."},"volume":35,"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"researchdata_availability":"upon request","year":"2025","doi":"10.1111/bpa.13279","OA_type":"gold","quality_controlled":"1","status":"public","issue":"2","publisher":"Wiley","acknowledgement":"Funding sources were Spanish Ministerio de Economía y Competitividad, Junta de Comunidades de Castilla-La Mancha (Spain), Life Science Innovation Center at University of Fukui and German Research Foundation.\r\nGrants RTI2018-095812-B-I00 and PID2021-125875OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” to Rafael Luján. This study was also supported by a grant from Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000229 and SBPLY/21/180501/000064) and Universidad de Castilla-La Mancha (2023-GRIN-34187) to Rafael Luján, and Life Science Innovation Center (Research and Education Program for Life Science) at University of Fukui and JSPS KAKENHI Grant Numbers 16H04662, 17K19446, 18H05120 to Yugo Fukazawa and Margarita Salas fellowship from Ministerio de Universidades and Universidad de Castilla-La Mancha to Alejandro Martín-Belmonte. German Research Foundation (DFG FOR 2143) and BIOSS-2 to Akos Kulik.","abstract":[{"text":"Voltage-gated CaV2.1 (P/Q-type) Ca2+ channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and to processes such as learning and memory. Despite their recognized importance in neural function, there is limited information on their potential involvement in neurodegenerative conditions such as Alzheimer's disease (AD). Here, we aimed to explore the impact of AD pathology on the density and nanoscale compartmentalization of CaV2.1 channels in the hippocampus in association with GABAB receptors. Histoblotting experiments showed that the density of CaV2.1 channel was significantly reduced in the hippocampus of APP/PS1 mice in a laminar-dependent manner. CaV2.1 channel was enriched in the active zone of the axon terminals and was present at a very low density over the surface of dendritic tree of the CA1 pyramidal cells, as shown by quantitative SDS-digested freeze-fracture replica labelling (SDS-FRL). In APP/PS1 mice, the density of CaV2.1 channel in the active zone was significantly reduced in the strata radiatum and lacunosum-moleculare, while it remained unaltered in the stratum oriens. The decline in Cav2.1 channel density was found to be associated with a corresponding impairment in the GABAergic synaptic function, as evidenced by electrophysiological experiments carried out in the hippocampus of APP/PS1 mice. Remarkably, double SDS-FRL showed a co-clustering of CaV2.1 channel and GABAB1 receptor in nanodomains (~40–50 nm) in wild type mice, while in APP/PS1 mice this nanoarchitecture was absent. Together, these findings suggest that the AD pathology-induced reduction in CaV2.1 channel density and CaV2.1-GABAB1 de-clustering may play a role in the synaptic transmission alterations shown in the AD hippocampus. Therefore, uncovering these layer-dependent changes in P/Q calcium currents associated with AD pathology can benefit the development of future strategies for AD management.","lang":"eng"}],"title":"Nanoarchitecture of CaV>2.1 channels and GABAB receptors in the mouse hippocampus: Impact of APP/PS1 pathology","date_created":"2024-07-22T07:48:20Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"RySh"}],"article_type":"original","_id":"17293","DOAJ_listed":"1","dataavailabilitystatement":"All data used and/or analyzed during the current study are available from the corresponding author on reasonable request.","month":"03","publication":"Brain Pathology","oa_version":"Published Version","file_date_updated":"2025-04-16T09:56:08Z","intvolume":"        35","das_tickbox":"1","file":[{"creator":"dernst","file_name":"2025_BrainPathology_MartinBelmonte.pdf","success":1,"file_id":"19582","date_updated":"2025-04-16T09:56:08Z","access_level":"open_access","date_created":"2025-04-16T09:56:08Z","content_type":"application/pdf","file_size":8767863,"checksum":"75a172800ab2e949abb66fba97cf70f0","relation":"main_file"}],"isi":1,"date_updated":"2026-10-21T08:30:00Z","oa":1,"article_number":"e13279","supplementarymaterial":"yes","publication_identifier":{"eissn":["1750-3639"],"issn":["1015-6305"]},"scopus_import":"1","author":[{"last_name":"Martín‐Belmonte","full_name":"Martín‐Belmonte, Alejandro","first_name":"Alejandro"},{"first_name":"Carolina","full_name":"Aguado, Carolina","last_name":"Aguado"},{"first_name":"Rocío","full_name":"Alfaro‐Ruiz, Rocío","last_name":"Alfaro‐Ruiz"},{"last_name":"Kulik","full_name":"Kulik, Akos","first_name":"Akos"},{"first_name":"Luis","full_name":"de la Ossa, Luis","last_name":"de la Ossa"},{"last_name":"Moreno‐Martínez","full_name":"Moreno‐Martínez, Ana Esther","first_name":"Ana Esther"},{"first_name":"Samuel","full_name":"Alberquilla, Samuel","last_name":"Alberquilla"},{"full_name":"García‐Carracedo, Lucía","first_name":"Lucía","last_name":"García‐Carracedo"},{"full_name":"Fernández, Miriam","first_name":"Miriam","last_name":"Fernández"},{"full_name":"Fajardo‐Serrano, Ana","first_name":"Ana","last_name":"Fajardo‐Serrano"},{"last_name":"Aso","first_name":"Ester","full_name":"Aso, Ester"},{"full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Martín","full_name":"Martín, Eduardo D.","first_name":"Eduardo D."},{"first_name":"Yugo","full_name":"Fukazawa, Yugo","last_name":"Fukazawa"},{"last_name":"Ciruela","first_name":"Francisco","full_name":"Ciruela, Francisco"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"}],"day":"01","type":"journal_article","article_processing_charge":"Yes","has_accepted_license":"1","ddc":["570"],"fulldoi":"https://doi.org/10.1111/bpa.13279","date_published":"2025-03-01T00:00:00Z","pmid":1,"external_id":{"isi":["001250034200001"],"pmid":["38887180"]},"language":[{"iso":"eng"}]},{"type":"journal_article","PlanS_conform":"1","article_processing_charge":"Yes (via OA deal)","day":"01","scopus_import":"1","publication_identifier":{"issn":["1424-0637"]},"author":[{"orcid":"0000-0003-4476-2288","last_name":"Lauritsen","full_name":"Lauritsen, Asbjørn Bækgaard","first_name":"Asbjørn Bækgaard","id":"e1a2682f-dc8d-11ea-abe3-81da9ac728f1"}],"page":"203-243","corr_author":"1","supplementarymaterial":"no","language":[{"iso":"eng"}],"date_published":"2025-01-01T00:00:00Z","external_id":{"pmid":["39926012"],"isi":["001261197700002"]},"pmid":1,"has_accepted_license":"1","ddc":["510"],"fulldoi":"https://doi.org/10.1007/s00023-024-01450-1","acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria).\r\nWe thank Alessandro Giuliani and Robert Seiringer for helpful discussions and Robert Seiringer for his comments on the manuscript. Financial support by the Austrian Science Fund (FWF) through Grant https://doi.org/10.55776/I6427 (as part of the SFB/TRR 352) is gratefully acknowledged.","abstract":[{"text":"We prove an upper bound on the energy density of the dilute spin-\\(\\frac {1}{2}\\) Fermi gas capturing the leading correction to the kinetic energy\\(8\\pi a\\rho _\\uparrow\\rho _\\downarrow\\) with an error of size smaller than\\(a\\rho^{2}(a^ 3\\rho)^{1/3-\\varepsilon}\\) for any\\(\\varepsilon> 0\\), where a denotes the scattering length of the interaction. The result is valid for a large class of interactions including interactions with a hard core. A central ingredient in the proof is a rigorous version of a fermionic cluster expansion adapted from the formal expansion of Gaudin et al. (Nucl Phys A 176(2):237–260, 1971. https://doi.org/10.1016/0375-9474(71)90267-3).","lang":"eng"}],"title":"Almost optimal upper bound for the ground state energy of a dilute Fermi gas via cluster expansion","quality_controlled":"1","status":"public","publisher":"Springer Nature","project":[{"grant_number":"I06427","_id":"bda63fe5-d553-11ed-ba76-a16e3d2f256b","name":"Mathematical Challenges in BCS Theory of Superconductivity"}],"doi":"10.1007/s00023-024-01450-1","OA_type":"hybrid","OA_place":"publisher","citation":{"chicago":"Lauritsen, Asbjørn Bækgaard. “Almost Optimal Upper Bound for the Ground State Energy of a Dilute Fermi Gas via Cluster Expansion.” <i>Annales Henri Poincare</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s00023-024-01450-1\">https://doi.org/10.1007/s00023-024-01450-1</a>.","apa":"Lauritsen, A. B. (2025). Almost optimal upper bound for the ground state energy of a dilute Fermi gas via cluster expansion. <i>Annales Henri Poincare</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00023-024-01450-1\">https://doi.org/10.1007/s00023-024-01450-1</a>","short":"A.B. Lauritsen, Annales Henri Poincare 26 (2025) 203–243.","ieee":"A. B. Lauritsen, “Almost optimal upper bound for the ground state energy of a dilute Fermi gas via cluster expansion,” <i>Annales Henri Poincare</i>, vol. 26. Springer Nature, pp. 203–243, 2025.","ista":"Lauritsen AB. 2025. Almost optimal upper bound for the ground state energy of a dilute Fermi gas via cluster expansion. Annales Henri Poincare. 26, 203–243.","ama":"Lauritsen AB. Almost optimal upper bound for the ground state energy of a dilute Fermi gas via cluster expansion. <i>Annales Henri Poincare</i>. 2025;26:203-243. doi:<a href=\"https://doi.org/10.1007/s00023-024-01450-1\">10.1007/s00023-024-01450-1</a>","mla":"Lauritsen, Asbjørn Bækgaard. “Almost Optimal Upper Bound for the Ground State Energy of a Dilute Fermi Gas via Cluster Expansion.” <i>Annales Henri Poincare</i>, vol. 26, Springer Nature, 2025, pp. 203–43, doi:<a href=\"https://doi.org/10.1007/s00023-024-01450-1\">10.1007/s00023-024-01450-1</a>."},"publication_status":"published","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":26,"year":"2025","researchdata_availability":"no","das_tickbox":"0","related_material":{"record":[{"status":"public","id":"18135","relation":"dissertation_contains"}]},"date_updated":"2026-10-21T08:28:52Z","file":[{"file_id":"20125","date_updated":"2025-08-05T11:42:27Z","success":1,"creator":"dernst","file_name":"2025_AnnalesHenriPoincare_Lauritsen.pdf","relation":"main_file","checksum":"01b6572f55f721e97498522c85072ed2","file_size":797241,"content_type":"application/pdf","date_created":"2025-08-05T11:42:27Z","access_level":"open_access"}],"isi":1,"oa":1,"oa_version":"Published Version","publication":"Annales Henri Poincare","file_date_updated":"2025-08-05T11:42:27Z","intvolume":"        26","_id":"17240","month":"01","date_created":"2024-07-14T22:01:12Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"RoSe"}],"article_type":"original"},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2025","publication_status":"published","OA_place":"publisher","citation":{"ista":"Sobarzo Ponce JCA. 2025. Tribocharging of identical insulators: Triboelectric series, triboelectric cycles and surface charges. Institute of Science and Technology Austria.","ama":"Sobarzo Ponce JCA. Tribocharging of identical insulators: Triboelectric series, triboelectric cycles and surface charges. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20203\">10.15479/AT-ISTA-20203</a>","mla":"Sobarzo Ponce, Juan Carlos A. <i>Tribocharging of Identical Insulators: Triboelectric Series, Triboelectric Cycles and Surface Charges</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20203\">10.15479/AT-ISTA-20203</a>.","chicago":"Sobarzo Ponce, Juan Carlos A. “Tribocharging of Identical Insulators: Triboelectric Series, Triboelectric Cycles and Surface Charges.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20203\">https://doi.org/10.15479/AT-ISTA-20203</a>.","apa":"Sobarzo Ponce, J. C. A. (2025). <i>Tribocharging of identical insulators: Triboelectric series, triboelectric cycles and surface charges</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20203\">https://doi.org/10.15479/AT-ISTA-20203</a>","short":"J.C.A. Sobarzo Ponce, Tribocharging of Identical Insulators: Triboelectric Series, Triboelectric Cycles and Surface Charges, Institute of Science and Technology Austria, 2025.","ieee":"J. C. A. Sobarzo Ponce, “Tribocharging of identical insulators: Triboelectric series, triboelectric cycles and surface charges,” Institute of Science and Technology Austria, 2025."},"doi":"10.15479/AT-ISTA-20203","status":"public","project":[{"call_identifier":"H2020","grant_number":"949120","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","name":"Tribocharge: a multi-scale approach to an enduring problem in physics"}],"publisher":"Institute of Science and Technology Austria","supervisor":[{"full_name":"Waitukaitis, Scott R","first_name":"Scott R","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","last_name":"Waitukaitis","orcid":"0000-0002-2299-3176"}],"title":"Tribocharging of identical insulators: Triboelectric series, triboelectric cycles and surface charges","abstract":[{"lang":"eng","text":"Tribocharging, or contact electrification, is the phenomenon in which two initially neutral materials exchange electric charge through contact and subsequent separation. While it is widely observed in everyday life and crucial to numerous natural processes, even the most basic aspects of tribocharging are still a mystery—what are the charge carriers involved and what drives their exchange? This work spans three separate projects that address different aspects of tribocharging. First, we introduce a novel strategy combining Finite Element Method (FEM) simulations with Kelvin Probe Force Microscopy (KPFM) to quantitatively extract surface charge density from surface voltage maps. Second, we present a simple theoretical model that allows for the existence of triboelectric cycles, under the assumption that multiple charge carrying species are involved. Third, we present experimental evidence that identical materials can spontaneously evolve into a triboelectric series, driven by contact history. Modeling this behavior enables the replication of experimental results with simulations, and even experimentally forcing the appearance of a pre-designed series by manipulating contact history. Together, the findings from these projects challenge traditional views on tribocharging, provide new tools for probing it, and open up new avenues of research—all with the hopes of bringing us closer to understanding this puzzling phenomenon."}],"acknowledgement":"The project in Chapter 2 has received funding from the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation programme (Grant Agreement\r\nNo. 949120).\r\nThe project in Chapter 3 has received funding from the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation programme (Grant Agreement\r\nNo. 949120).\r\nThe project in Chapter 4 has received financing from the European Research Council grant\r\nagreement No. 949120 under the European Union’s Horizon 2020 research and innovation\r\nprogramme. The Analytical Instrumentation Center of the TU Wien acknowledges support by\r\nthe FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge the state\r\nof Lower Austria and the European Regional Development Fund under grant no. WST3-F542638/004-2021.\r\n","department":[{"_id":"GradSch"},{"_id":"ScWa"}],"date_created":"2025-08-21T11:42:59Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","month":"08","ec_funded":1,"_id":"20203","file_date_updated":"2025-08-28T08:19:07Z","oa_version":"Published Version","date_updated":"2026-10-21T08:38:30Z","file":[{"relation":"main_file","file_size":12667200,"checksum":"661b9d3786cfc985be811befc3262bf5","content_type":"application/pdf","date_created":"2025-08-27T14:50:32Z","access_level":"open_access","date_updated":"2025-08-27T14:50:32Z","file_id":"20237","success":1,"file_name":"2025_Sobarzo_JuanCarlos_Thesis.pdf","creator":"jsobarzo"},{"file_id":"20238","date_updated":"2025-08-28T08:19:07Z","creator":"jsobarzo","file_name":"2025_Sobarzo_JuanCarlos_Thesis.zip","checksum":"ca2f24e6c3b55912982521707552a0f5","file_size":18940521,"relation":"source_file","access_level":"closed","date_created":"2025-08-27T14:50:32Z","content_type":"application/x-zip-compressed"}],"oa":1,"related_material":{"record":[{"status":"public","id":"12109","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"19278"},{"id":"15322","status":"public","relation":"part_of_dissertation"}]},"page":"96","corr_author":"1","author":[{"full_name":"Sobarzo Ponce, Juan Carlos A","first_name":"Juan Carlos A","id":"4B807D68-AE37-11E9-AC72-31CAE5697425","last_name":"Sobarzo Ponce"}],"doi_confirm":"1","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-062-6"]},"day":"27","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"article_processing_charge":"No","type":"dissertation","ddc":["530"],"degree_awarded":"PhD","fulldoi":"https://doi.org/10.15479/AT-ISTA-20203","has_accepted_license":"1","date_published":"2025-08-27T00:00:00Z","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}]},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2025","citation":{"ama":"Mondal S. Oxygen and sulfur redox: Conversion kinetics and phase equilibria. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20607\">10.15479/AT-ISTA-20607</a>","mla":"Mondal, Soumyadip. <i>Oxygen and Sulfur Redox: Conversion Kinetics and Phase Equilibria</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20607\">10.15479/AT-ISTA-20607</a>.","ista":"Mondal S. 2025. Oxygen and sulfur redox: Conversion kinetics and phase equilibria. Institute of Science and Technology Austria.","short":"S. Mondal, Oxygen and Sulfur Redox: Conversion Kinetics and Phase Equilibria, Institute of Science and Technology Austria, 2025.","ieee":"S. Mondal, “Oxygen and sulfur redox: Conversion kinetics and phase equilibria,” Institute of Science and Technology Austria, 2025.","chicago":"Mondal, Soumyadip. “Oxygen and Sulfur Redox: Conversion Kinetics and Phase Equilibria.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20607\">https://doi.org/10.15479/AT-ISTA-20607</a>.","apa":"Mondal, S. (2025). <i>Oxygen and sulfur redox: Conversion kinetics and phase equilibria</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20607\">https://doi.org/10.15479/AT-ISTA-20607</a>"},"OA_place":"publisher","publication_status":"published","doi":"10.15479/AT-ISTA-20607","status":"public","project":[{"grant_number":"P37169","_id":"8df062be-16d5-11f0-9cad-f559b6612c7e","name":"Singlet oxygen in non-aqueous oxygen redox chemistry"},{"grant_number":"COE05","_id":"5eaf4378-b033-11f1-b276-f928018a46c1","name":"Materials for Energy Conversion and Storage (Freunberger)"}],"publisher":"Institute of Science and Technology Austria","supervisor":[{"full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger"}],"title":"Oxygen and sulfur redox: Conversion kinetics and phase equilibria","acknowledgement":"I gratefully acknowledge the support of the ISTA Graduate School and the Scientific Service Units of\r\nISTA, whose resources made this work possible—especially the Imaging & Optics Facility, the Lab\r\nSupport Facility, and the Miba Machine Shop. I would like to thank two staff scientists in particular:\r\nRobert Hauschild (Imaging & Optics Facility) and Daniel Balazs (Lab Support Facility), for their\r\nassistance and advice. My PhD was partially funded by the Austrian Science Fund (FWF)\r\n(10.55776/P37169 and 10.55776/COE5).","department":[{"_id":"GradSch"},{"_id":"StFr"}],"date_created":"2025-11-07T12:40:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"09","_id":"20607","file_date_updated":"2025-11-13T16:47:47Z","oa_version":"Published 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V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Lindorfer","full_name":"Lindorfer, Lukas","first_name":"Lukas","id":"85f0e6d3-06b3-11ec-8982-8c5049fa4455"},{"full_name":"Robb, Jennifer","first_name":"Jennifer","id":"7bc2734a-e2c6-11ea-9824-a2ed5f0662a8","last_name":"Robb"},{"first_name":"Farnaz","id":"0344bfb9-3feb-11ee-87e9-c27edc800bcd","full_name":"Beikzadeh Abbasi, Farnaz","last_name":"Beikzadeh Abbasi"},{"full_name":"Strahodinsky, Florian","first_name":"Florian","id":"979E35EE-C996-11E9-8C7C-CF13E6697425","last_name":"Strahodinsky"},{"full_name":"Leitner, Hanna","first_name":"Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","last_name":"Leitner"},{"last_name":"Rajendran","full_name":"Rajendran, Harikrishnan","id":"876b6b34-8ff4-11ec-97c9-8d95a7aae416","first_name":"Harikrishnan"},{"full_name":"Schmitt, Thomas","first_name":"Thomas","last_name":"Schmitt"},{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, 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Here we show by behavioural, chemical, immunological and infection load analyses that sick ant pupae instead actively emit a chemical signal that in itself is sufficient to trigger their own destruction by colony members. In our experiments, this altruistic disease-signalling was performed only by worker but not queen pupae. The lack of signalling by queen pupae did not constitute cheating behaviour, but reflected their superior immune capabilities. Worker pupae suffered from extensive pathogen replication whereas queen pupae were able to restrain their infection. Our data suggest the evolution of a finely-tuned signalling system in which it is not the induction of an individual’s immune response, but rather its failure to overcome the infection, that triggers pupal signalling for sacrifice. This demonstrates a balanced interplay between individual and social immunity that efficiently achieves whole-colony health."}],"acknowledgement":"We thank Joergen Eilenberg and Nicolai V. Meyling for the fungal strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant collection. We also thank the Social Immunity team, in particular David Moreno Martínez, Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular support, as well as Friedrich Fochler for technical support with the chemical analysis, and the ISTA Lab Support Facility, including the mass spectrometry unit, for general and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull and Michael Sixt for project discussion, and the Social Immunity team for comments on the manuscript. The study was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation Programme (No. 771402; EPIDEMICSonCHIP) to SC.","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"researchdata_availability":"no","volume":16,"year":"2025","citation":{"apa":"Dawson, E., Hönigsberger, M., Kampleitner, N., Grasse, A. V., Lindorfer, L., Robb, J., … Cremer, S. (2025). Altruistic disease signalling in ant colonies. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-66175-z\">https://doi.org/10.1038/s41467-025-66175-z</a>","chicago":"Dawson, Erika, Michaela Hönigsberger, Niklas Kampleitner, Anna V Grasse, Lukas Lindorfer, Jennifer Robb, Farnaz Beikzadeh, et al. “Altruistic Disease Signalling in Ant Colonies.” <i>Nature Communications</i>. 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Nature Communications. 16, 10511.","mla":"Dawson, Erika, et al. “Altruistic Disease Signalling in Ant Colonies.” <i>Nature Communications</i>, vol. 16, 10511, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-66175-z\">10.1038/s41467-025-66175-z</a>.","ama":"Dawson E, Hönigsberger M, Kampleitner N, et al. 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Meyling for the fungal strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant collection. We also thank the Social Immunity team, in particular David Moreno Martínez, Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular support, as well as Friedrich Fochler for technical support with the chemical analysis, and the ISTA Lab Support Facility, including the mass spectrometry unit, for general and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull and Michael Sixt for project discussion and the Social Immunity team for comments on the manuscript. The study was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation Programme (No. 771402; EPIDEMICSonCHIP) to SC. ","title":"Altruistic disease signalling in ant colonies","abstract":[{"text":"Sick individuals often conceal their disease status to group members, thereby preventing social exclusion or aggression. Here we show by behavioural, chemical, immunological and infection load analyses that sick ant pupae instead actively emit a chemical signal that in itself is sufficient to trigger their own destruction by colony members. In our experiments, this altruistic disease-signalling was performed only by worker but not queen pupae. The lack of signalling by queen pupae did not constitute cheating behaviour, but reflected their superior immune capabilities. Worker pupae suffered from extensive pathogen replication whereas queen pupae were able to restrain their infection. Our data suggest the evolution of a finely-tuned signalling system in which it is not the induction of an individual’s immune response, but rather its failure to overcome the infection, that triggers pupal signalling for sacrifice. This demonstrates a balanced interplay between individual and social immunity that efficiently achieves whole-colony health. ","lang":"eng"}],"citation":{"apa":"Cremer, S. (2025). Altruistic disease signalling in ant colonies. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20471\">https://doi.org/10.15479/AT-ISTA-20471</a>","chicago":"Cremer, Sylvia. “Altruistic Disease Signalling in Ant Colonies.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20471\">https://doi.org/10.15479/AT-ISTA-20471</a>.","ieee":"S. Cremer, “Altruistic disease signalling in ant colonies.” Institute of Science and Technology Austria, 2025.","short":"S. Cremer, (2025).","ista":"Cremer S. 2025. Altruistic disease signalling in ant colonies, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-20471\">10.15479/AT-ISTA-20471</a>.","mla":"Cremer, Sylvia. <i>Altruistic Disease Signalling in Ant Colonies</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20471\">10.15479/AT-ISTA-20471</a>.","ama":"Cremer S. Altruistic disease signalling in ant colonies. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20471\">10.15479/AT-ISTA-20471</a>"},"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"year":"2025","doi":"10.15479/AT-ISTA-20471","date_published":"2025-10-16T00:00:00Z","keyword":["host-parasite interactions","social insects","social immunity","chemical communication","cooperation"],"has_accepted_license":"1","ddc":["570"],"fulldoi":"https://doi.org/10.15479/AT-ISTA-20471","day":"16","type":"research_data","contributor":[{"id":"31B4E2D0-F248-11E8-B48F-1D18A9856A87","first_name":"Erika","last_name":"Dawson"},{"last_name":"Hönigsberger","id":"953894f3-25bd-11ec-8556-f70a9d38ef60","first_name":"Michaela"},{"id":"2AC57FAC-F248-11E8-B48F-1D18A9856A87","first_name":"Niklas","last_name":"Kampleitner"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","last_name":"Grasse"},{"id":"85f0e6d3-06b3-11ec-8982-8c5049fa4455","first_name":"Lukas","last_name":"Lindorfer"},{"last_name":"Robb","first_name":"Jennifer","id":"7bc2734a-e2c6-11ea-9824-a2ed5f0662a8"},{"first_name":"Farnaz","id":"0344bfb9-3feb-11ee-87e9-c27edc800bcd","last_name":"Beikzadeh Abbasi"},{"first_name":"Florian","id":"979E35EE-C996-11E9-8C7C-CF13E6697425","last_name":"Strahodinsky"},{"first_name":"Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","last_name":"Leitner"},{"last_name":"Rajendran","id":"876b6b34-8ff4-11ec-97c9-8d95a7aae416","first_name":"Harikrishnan"},{"first_name":"Thomas","last_name":"Schmitt"},{"orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"article_processing_charge":"No","corr_author":"1","author":[{"orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","full_name":"Cremer, Sylvia"}]},{"day":"01","article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","type":"journal_article","supplementarymaterial":"no","page":"1646-1660","corr_author":"1","author":[{"first_name":"Bartosz","full_name":"Naskręcki, Bartosz","last_name":"Naskręcki"},{"last_name":"Verzobio","orcid":"0000-0002-0854-0306","full_name":"Verzobio, Matteo","id":"7aa8f170-131e-11ed-88e1-a9efd01027cb","first_name":"Matteo"}],"scopus_import":"1","publication_identifier":{"issn":["0308-2105"],"eissn":["1473-7124"]},"arxiv":1,"external_id":{"isi":["001174907100001"],"arxiv":["2203.02015"]},"date_published":"2025-10-01T00:00:00Z","language":[{"iso":"eng"}],"keyword":["Elliptic curves","Néron models","division polynomials","height functions","discrete valuation rings"],"fulldoi":"https://doi.org/10.1017/prm.2024.7","ddc":["510"],"has_accepted_license":"1","publisher":"Cambridge University Press","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"}],"status":"public","issue":"5","quality_controlled":"1","abstract":[{"lang":"eng","text":"In this note, we prove a formula for the cancellation exponent  kv,n between division polynomials  ψn  and  ϕn  associated with a sequence  {nP}n∈N of points on an elliptic curve  E  defined over a discrete valuation field  K. The formula greatly generalizes the previously known special cases and treats also the case of non-standard Kodaira types for non-perfect residue fields."}],"title":"Common valuations of division polynomials","acknowledgement":"Silverman, and Paul Voutier for the comments on the earlier version of this paper. The first author acknowledges the support by Dioscuri programme initiated by the Max Planck Society, jointly managed with the National Science Centre (Poland), and mutually funded by the Polish Ministry of Science and Higher Education and the German Federal Ministry of Education and Research. The second author has been supported by MIUR (Italy) through PRIN 2017 ‘Geometric, algebraic and analytic methods in arithmetic’ and has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 101034413.","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":155,"researchdata_availability":"no","year":"2025","citation":{"ista":"Naskręcki B, Verzobio M. 2025. Common valuations of division polynomials. Proceedings of the Royal Society of Edinburgh Section A: Mathematics. 155(5), 1646–1660.","mla":"Naskręcki, Bartosz, and Matteo Verzobio. “Common Valuations of Division Polynomials.” <i>Proceedings of the Royal Society of Edinburgh Section A: Mathematics</i>, vol. 155, no. 5, Cambridge University Press, 2025, pp. 1646–60, doi:<a href=\"https://doi.org/10.1017/prm.2024.7\">10.1017/prm.2024.7</a>.","ama":"Naskręcki B, Verzobio M. Common valuations of division polynomials. <i>Proceedings of the Royal Society of Edinburgh Section A: Mathematics</i>. 2025;155(5):1646-1660. doi:<a href=\"https://doi.org/10.1017/prm.2024.7\">10.1017/prm.2024.7</a>","apa":"Naskręcki, B., &#38; Verzobio, M. (2025). Common valuations of division polynomials. <i>Proceedings of the Royal Society of Edinburgh Section A: Mathematics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/prm.2024.7\">https://doi.org/10.1017/prm.2024.7</a>","chicago":"Naskręcki, Bartosz, and Matteo Verzobio. “Common Valuations of Division Polynomials.” <i>Proceedings of the Royal Society of Edinburgh Section A: Mathematics</i>. Cambridge University Press, 2025. <a href=\"https://doi.org/10.1017/prm.2024.7\">https://doi.org/10.1017/prm.2024.7</a>.","ieee":"B. Naskręcki and M. Verzobio, “Common valuations of division polynomials,” <i>Proceedings of the Royal Society of Edinburgh Section A: Mathematics</i>, vol. 155, no. 5. Cambridge University Press, pp. 1646–1660, 2025.","short":"B. Naskręcki, M. Verzobio, Proceedings of the Royal Society of Edinburgh Section A: Mathematics 155 (2025) 1646–1660."},"publication_status":"published","OA_place":"publisher","OA_type":"hybrid","doi":"10.1017/prm.2024.7","intvolume":"       155","file_date_updated":"2025-12-30T06:45:47Z","publication":"Proceedings of the Royal Society of Edinburgh Section A: Mathematics","oa_version":"Published Version","oa":1,"isi":1,"date_updated":"2026-10-21T11:01:35Z","file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2025-12-30T06:45:47Z","file_size":477624,"checksum":"c5ec6e29aca2fb4533cb95fac409a0b2","relation":"main_file","creator":"dernst","file_name":"2025_ProceedingsRoyalSocEdinburghA_Naskrecki.pdf","file_id":"20878","date_updated":"2025-12-30T06:45:47Z","success":1}],"das_tickbox":"0","article_type":"original","department":[{"_id":"TiBr"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2023-01-16T11:45:22Z","month":"10","_id":"12311","ec_funded":1},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-12-22T23:01:48Z","article_type":"original","department":[{"_id":"TiBr"}],"_id":"18705","month":"04","dataavailabilitystatement":"Data sharing is not applicable to this article as no datasets were generated or analysed\r\nduring the current study.","oa_version":"Published Version","publication":"Mathematische Annalen","intvolume":"       391","file_date_updated":"2025-04-16T09:38:55Z","das_tickbox":"1","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"18293"}]},"oa":1,"file":[{"file_size":650021,"checksum":"dcf57a8b01332c36e0cf2b0d1aeecb36","relation":"main_file","access_level":"open_access","date_created":"2025-04-16T09:38:55Z","content_type":"application/pdf","success":1,"date_updated":"2025-04-16T09:38:55Z","file_id":"19579","file_name":"2025_MathAnnalen_Glas.pdf","creator":"dernst"}],"isi":1,"date_updated":"2026-10-21T11:06:30Z","citation":{"ama":"Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms over Fq(t). <i>Mathematische Annalen</i>. 2025;391:5485-5533. doi:<a href=\"https://doi.org/10.1007/s00208-024-03035-z\">10.1007/s00208-024-03035-z</a>","mla":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” <i>Mathematische Annalen</i>, vol. 391, Springer Nature, 2025, pp. 5485–533, doi:<a href=\"https://doi.org/10.1007/s00208-024-03035-z\">10.1007/s00208-024-03035-z</a>.","ista":"Glas J, Hochfilzer L. 2025. On a question of Davenport and diagonal cubic forms over Fq(t). Mathematische Annalen. 391, 5485–5533.","short":"J. Glas, L. Hochfilzer, Mathematische Annalen 391 (2025) 5485–5533.","ieee":"J. Glas and L. Hochfilzer, “On a question of Davenport and diagonal cubic forms over Fq(t),” <i>Mathematische Annalen</i>, vol. 391. Springer Nature, pp. 5485–5533, 2025.","chicago":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” <i>Mathematische Annalen</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s00208-024-03035-z\">https://doi.org/10.1007/s00208-024-03035-z</a>.","apa":"Glas, J., &#38; Hochfilzer, L. (2025). On a question of Davenport and diagonal cubic forms over Fq(t). <i>Mathematische Annalen</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00208-024-03035-z\">https://doi.org/10.1007/s00208-024-03035-z</a>"},"OA_place":"publisher","publication_status":"published","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":391,"researchdata_availability":"not applicable","year":"2025","doi":"10.1007/s00208-024-03035-z","OA_type":"hybrid","quality_controlled":"1","publisher":"Springer Nature","status":"public","acknowledgement":"Open Access funding enabled and organized by Projekt DEAL.\r\nThe authors would like to thank Tim Browning for suggesting this project. Further they are grateful for his and Damaris Schindler’s helpful comments. We would also like to thank Efthymios Sofos for bringing Davenport’s question to our attention and Keith Matthews for providing us with scanned copies of the original correspondence. Finally we would like to thank the reviewer for helpful comments.","abstract":[{"lang":"eng","text":"Given a non-singular diagonal cubic hypersurface X⊂Pn−1 over Fq(t) with char(Fq)≠3, we show that the number of rational points of height at most |P| is O(|P|3+ε) for n=6 and O(|P|2+ε) for n=4. In fact, if n=4 and char(Fq)>3 we prove that the number of rational points away from any rational line contained in X is bounded by O(|P|3/2+ε). From the result in 6 variables we deduce weak approximation for diagonal cubic hypersurfaces for n≥7 over Fq(t) when char(Fq)>3 and handle Waring's problem for cubes in 7 variables over Fq(t) when char(Fq)≠3. Our results answer a question of Davenport regarding the number of solutions of bounded height to x31+x32+x33=x34+x35+x36 with xi∈Fq[t]."}],"title":"On a question of Davenport and diagonal cubic forms over Fq(t)","has_accepted_license":"1","fulldoi":"https://doi.org/10.1007/s00208-024-03035-z","ddc":["510"],"date_published":"2025-04-01T00:00:00Z","external_id":{"isi":["001376740400001"],"arxiv":["2208.05422"]},"arxiv":1,"language":[{"iso":"eng"}],"page":"5485-5533","corr_author":"1","supplementarymaterial":"no","publication_identifier":{"issn":["0025-5831"],"eissn":["1432-1807"]},"scopus_import":"1","author":[{"last_name":"Glas","id":"d6423cba-dc74-11ea-a0a7-ee61689ff5fb","first_name":"Jakob","full_name":"Glas, Jakob"},{"last_name":"Hochfilzer","first_name":"Leonhard","full_name":"Hochfilzer, Leonhard"}],"day":"01","type":"journal_article","article_processing_charge":"Yes (via OA deal)"},{"has_accepted_license":"1","fulldoi":"https://doi.org/10.1007/s10703-024-00447-0","ddc":["000"],"language":[{"iso":"eng"}],"date_published":"2025-05-01T00:00:00Z","external_id":{"isi":["001230084200001"],"arxiv":["2002.06465"]},"arxiv":1,"publication_identifier":{"eissn":["1572-8102"],"issn":["0925-9856"]},"scopus_import":"1","author":[{"full_name":"Bartocci, Ezio","first_name":"Ezio","last_name":"Bartocci"},{"first_name":"Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","full_name":"Ferrere, Thomas","last_name":"Ferrere","orcid":"0000-0001-5199-3143"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724","last_name":"Henzinger"},{"full_name":"Nickovic, Dejan","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","first_name":"Dejan","last_name":"Nickovic"},{"full_name":"Oliveira da Costa, Ana","first_name":"Ana","id":"f347ec37-6676-11ee-b395-a888cb7b4fb4","last_name":"Oliveira da Costa","orcid":"0000-0002-8741-5799"}],"page":"3-48","corr_author":"1","supplementarymaterial":"yes","type":"journal_article","article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","day":"01","ec_funded":1,"_id":"17094","month":"05","dataavailabilitystatement":"This manuscript has no associated data.\r\n\r\n","date_created":"2024-06-02T22:00:57Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","department":[{"_id":"ToHe"}],"das_tickbox":"1","related_material":{"record":[{"id":"11355","status":"public","relation":"shorter_version"}]},"oa":1,"date_updated":"2026-10-21T12:02:29Z","file":[{"checksum":"244a71a916103b8ea08e9d0bab32bcd9","file_size":3860690,"relation":"main_file","access_level":"open_access","date_created":"2025-12-30T06:50:12Z","content_type":"application/pdf","success":1,"file_id":"20879","date_updated":"2025-12-30T06:50:12Z","creator":"dernst","file_name":"2025_FormalMethodsSysDesign_Bartocci.pdf"}],"isi":1,"publication":"Formal Methods in System Design","oa_version":"Published Version","intvolume":"        66","file_date_updated":"2025-12-30T06:50:12Z","doi":"10.1007/s10703-024-00447-0","OA_type":"hybrid","publication_status":"published","citation":{"ama":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Oliveira da Costa A. Information-flow interfaces. <i>Formal Methods in System Design</i>. 2025;66:3-48. doi:<a href=\"https://doi.org/10.1007/s10703-024-00447-0\">10.1007/s10703-024-00447-0</a>","mla":"Bartocci, Ezio, et al. “Information-Flow Interfaces.” <i>Formal Methods in System Design</i>, vol. 66, Springer Nature, 2025, pp. 3–48, doi:<a href=\"https://doi.org/10.1007/s10703-024-00447-0\">10.1007/s10703-024-00447-0</a>.","ista":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Oliveira da Costa A. 2025. Information-flow interfaces. Formal Methods in System Design. 66, 3–48.","short":"E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A. Oliveira da Costa, Formal Methods in System Design 66 (2025) 3–48.","ieee":"E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. Oliveira da Costa, “Information-flow interfaces,” <i>Formal Methods in System Design</i>, vol. 66. Springer Nature, pp. 3–48, 2025.","chicago":"Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and Ana Oliveira da Costa. “Information-Flow Interfaces.” <i>Formal Methods in System Design</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s10703-024-00447-0\">https://doi.org/10.1007/s10703-024-00447-0</a>.","apa":"Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., &#38; Oliveira da Costa, A. (2025). Information-flow interfaces. <i>Formal Methods in System Design</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10703-024-00447-0\">https://doi.org/10.1007/s10703-024-00447-0</a>"},"OA_place":"publisher","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":66,"year":"2025","researchdata_availability":"not applicable","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 956123 and it was funded in part by the Austrian Science Fund (FWF) project W1255-N23, by the Austrian FWF project ZK-35, by the FWF project SpyCoDe 10.55776/F85 and by the ERC-2020-AdG 101020093. This paper extends the text and the results of the manuscript published at FASE 2022 [1].","title":"Information-flow interfaces","abstract":[{"text":"Contract-based design is a promising methodology for taming the complexity of developing sophisticated systems. A formal contract distinguishes between assumptions, which are constraints that the designer of a component puts on the environments in which the component can be used safely, and guarantees, which are promises that the designer asks from the team that implements the component. A theory of formal contracts can be formalized as an interface theory, which supports the composition and refinement of both assumptions and guarantees. Although there is a rich landscape of contract-based design methods that address functional and extra-functional properties, we present the first interface theory designed to ensure system-wide security properties. Our framework provides a refinement relation and a composition operation that support both incremental design and independent implementability. We develop our theory for both stateless and stateful interfaces. Additionally, we introduce information-flow contracts where assumptions and guarantees are sets of flow relations. We use these contracts to illustrate how to enrich information-flow interfaces with a semantic view. We illustrate the applicability of our framework with two examples inspired by the automotive domain.","lang":"eng"}],"quality_controlled":"1","publisher":"Springer Nature","project":[{"call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software"},{"name":"Interface Theory for Security and Privacy","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","grant_number":"F8502"}],"status":"public"}]