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One of the main ingredients in the proof is a rigorous implementation of the fermionic cluster expansion of Gaudin et al. (1971) [15]."}],"title":"Ground state energy of the dilute spin-polarized Fermi gas: Upper bound via cluster expansion","_id":"14931","date_created":"2024-02-04T23:00:53Z","author":[{"full_name":"Lauritsen, Asbjørn Bækgaard","orcid":"0000-0003-4476-2288","id":"e1a2682f-dc8d-11ea-abe3-81da9ac728f1","first_name":"Asbjørn Bækgaard","last_name":"Lauritsen"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert"}],"status":"public","supplementarymaterial":"no","date_updated":"2026-10-21T08:29:09Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"record":[{"status":"public","id":"18135","relation":"dissertation_contains"}]},"citation":{"mla":"Lauritsen, Asbjørn Bækgaard, and Robert Seiringer. “Ground State Energy of the Dilute Spin-Polarized Fermi Gas: Upper Bound via Cluster Expansion.” <i>Journal of Functional Analysis</i>, vol. 286, no. 7, 110320, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.jfa.2024.110320\">10.1016/j.jfa.2024.110320</a>.","ama":"Lauritsen AB, Seiringer R. Ground state energy of the dilute spin-polarized Fermi gas: Upper bound via cluster expansion. <i>Journal of Functional Analysis</i>. 2024;286(7). doi:<a href=\"https://doi.org/10.1016/j.jfa.2024.110320\">10.1016/j.jfa.2024.110320</a>","ista":"Lauritsen AB, Seiringer R. 2024. Ground state energy of the dilute spin-polarized Fermi gas: Upper bound via cluster expansion. Journal of Functional Analysis. 286(7), 110320.","ieee":"A. B. Lauritsen and R. Seiringer, “Ground state energy of the dilute spin-polarized Fermi gas: Upper bound via cluster expansion,” <i>Journal of Functional Analysis</i>, vol. 286, no. 7. Elsevier, 2024.","short":"A.B. Lauritsen, R. Seiringer, Journal of Functional Analysis 286 (2024).","chicago":"Lauritsen, Asbjørn Bækgaard, and Robert Seiringer. “Ground State Energy of the Dilute Spin-Polarized Fermi Gas: Upper Bound via Cluster Expansion.” <i>Journal of Functional Analysis</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.jfa.2024.110320\">https://doi.org/10.1016/j.jfa.2024.110320</a>.","apa":"Lauritsen, A. B., &#38; Seiringer, R. (2024). Ground state energy of the dilute spin-polarized Fermi gas: Upper bound via cluster expansion. <i>Journal of Functional Analysis</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jfa.2024.110320\">https://doi.org/10.1016/j.jfa.2024.110320</a>"},"project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","call_identifier":"H2020","grant_number":"694227"},{"_id":"bda63fe5-d553-11ed-ba76-a16e3d2f256b","name":"Mathematical Challenges in BCS Theory of Superconductivity","grant_number":"I06427"}],"publication_identifier":{"eissn":["1096-0783"],"issn":["0022-1236"]},"acknowledgement":"A.B.L. would like to thank Johannes Agerskov and Jan Philip Solovej for valuable discussions. We thank Alessandro Giuliani for helpful discussions and for pointing out the reference [18]. Funding from the European Union's Horizon 2020 research and innovation programme under the ERC grant agreement No 694227 is acknowledged. Financial support by the Austrian Science Fund (FWF) through project number I 6427-N (as part of the SFB/TRR 352) is gratefully acknowledged.","ec_funded":1,"publication":"Journal of Functional Analysis","scopus_import":"1","issue":"7","language":[{"iso":"eng"}]},{"acknowledgement":"We thank Armel Nicolas, Bella Bruszel and Ewelina Dutkiewicz from the ISTA Mass Spectrometry Service (Lab Services Facilities) for all Proteomics work, including samples preparation, LC/MS data acquisition, searches and data evaluation. We thank Prof. Peter Jonas for his suggestion on the involvement of potassium channels and members of the Neuroethology group for their comments on the manuscript. Katalin Szigeti and Julie Murmann for experimental help. This research was supported by the Scientific Service Units of ISTA through resources provided by the Lab Support Facility, the Imaging and Optics Facility, the Machine Shop Unit and the Preclinical Facility, especially Freyja Langer and Michael Schunn. ","status":"public","date_created":"2024-05-13T15:04:04Z","author":[{"full_name":"Burnett, Laura","orcid":"0000-0002-8937-410X","last_name":"Burnett","first_name":"Laura","id":"3B717F68-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter","first_name":"Peter","last_name":"Koppensteiner","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Symonova","first_name":"Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2012-9947","full_name":"Symonova, Olga"},{"full_name":"Masson, Tomas","orcid":"0000-0002-2634-6283","last_name":"Masson","first_name":"Tomas","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207"},{"full_name":"Vega Zuniga, Tomas A","first_name":"Tomas A","last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ximena","last_name":"Contreras","id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena"},{"first_name":"Thomas","last_name":"Rülicke","full_name":"Rülicke, Thomas"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"},{"full_name":"Jösch, Maximilian A","orcid":"0000-0002-3937-1330","last_name":"Jösch","first_name":"Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87"}],"title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","_id":"15385","abstract":[{"text":"Relevant information about the data can be found in the 'Readme_Data.txt' file. \r\nA previous version of the publication can be found on BioRxiv: https://www.biorxiv.org/content/10.1101/2022.10.11.511691v4\r\nand published in Plos Biology (2024)","lang":"eng"}],"oa_version":"Published Version","type":"research_data","citation":{"ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.” Institute of Science and Technology Austria, 2024.","ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>.","short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, (2024).","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>","mla":"Burnett, Laura, et al. <i>Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>.","apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>."},"related_material":{"record":[{"status":"public","id":"17142","relation":"used_in_publication"}]},"date_updated":"2026-10-21T08:31:42Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","corr_author":"1","oa":1,"day":"15","publisher":"Institute of Science and Technology Austria","month":"05","department":[{"_id":"MaJö"},{"_id":"PreCl"},{"_id":"SiHi"},{"_id":"RySh"},{"_id":"GaNo"}],"doi":"10.15479/AT:ISTA:15385","file":[{"date_created":"2024-05-15T06:09:17Z","checksum":"9205eb0876f0f08552dbad80d6884b4b","success":1,"relation":"main_file","creator":"mjoesch","access_level":"open_access","file_id":"15396","file_size":"1149617663","content_type":"application/zip","date_updated":"2024-05-15T06:09:17Z","file_name":"PatchClamp.zip"},{"creator":"mjoesch","relation":"main_file","access_level":"open_access","date_created":"2024-05-15T06:09:12Z","success":1,"file_size":"564903112","date_updated":"2024-05-15T06:09:12Z","content_type":"application/zip","file_name":"SiliconProbe.zip","file_id":"15397"},{"file_name":"WesternBlot.zip","content_type":"application/zip","date_updated":"2024-05-15T06:09:14Z","file_size":"11685703","file_id":"15398","access_level":"open_access","creator":"mjoesch","relation":"main_file","success":1,"checksum":"49a807bbab06b5fada38f532e2176e2e","date_created":"2024-05-15T06:09:14Z"},{"success":1,"date_created":"2024-05-15T06:09:38Z","checksum":"beeeeaa43770090f3b291209ed6b0623","access_level":"open_access","relation":"main_file","creator":"mjoesch","file_id":"15399","date_updated":"2024-05-15T06:09:38Z","content_type":"application/zip","file_name":"Behaviour.zip","file_size":"1335626779"},{"file_size":18841,"file_name":"Readme_Data.txt","date_updated":"2024-05-16T09:08:20Z","content_type":"text/plain","file_id":"15400","creator":"mjoesch","relation":"main_file","access_level":"open_access","date_created":"2024-05-16T09:08:20Z","checksum":"8862ad7719388304d1d19f8e7db8bb00","success":1}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"ddc":["570"],"year":"2024","article_processing_charge":"No","keyword":["ASD","periaqueductal gray","perception","behavior","potassium channels"],"has_accepted_license":"1","date_published":"2024-05-15T00:00:00Z","file_date_updated":"2024-05-16T09:08:20Z","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"Bio"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:15385"},{"isi":1,"volume":42,"file":[{"success":1,"date_created":"2025-01-09T07:48:01Z","checksum":"57d5fafb16f02dcb9f7dddb1bd7e2a71","access_level":"open_access","creator":"dernst","relation":"main_file","file_id":"18784","date_updated":"2025-01-09T07:48:01Z","content_type":"application/pdf","file_name":"2024_NatureBiotech_Michalska.pdf","file_size":26065165}],"researchdata_availability":"yes","doi":"10.1038/s41587-023-01911-8","day":"01","corr_author":"1","oa":1,"external_id":{"isi":["001065254200001"],"pmid":["37653226"]},"department":[{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"JoDa"},{"_id":"Bio"},{"_id":"RySh"}],"month":"07","publisher":"Springer Nature","date_published":"2024-07-01T00:00:00Z","file_date_updated":"2025-01-09T07:48:01Z","has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","fulldoi":"https://doi.org/10.1038/s41587-023-01911-8","das_tickbox":"1","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["570"],"quality_controlled":"1","pmid":1,"year":"2024","publication_status":"published","intvolume":"        42","OA_type":"hybrid","OA_place":"publisher","language":[{"iso":"eng"}],"publication":"Nature Biotechnology","scopus_import":"1","publication_identifier":{"eissn":["1546-1696"],"issn":["1087-0156"]},"acknowledgement":"We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).","ec_funded":1,"related_material":{"link":[{"relation":"software","url":"https://github.com/danzllab/CATS"}],"record":[{"status":"deleted","relation":"dissertation_contains","id":"18660"},{"status":"public","id":"13126","relation":"research_data"},{"status":"public","relation":"dissertation_contains","id":"18674"}]},"project":[{"call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","grant_number":"I03600"},{"grant_number":"W1232","_id":"2548AE96-B435-11E9-9278-68D0E5697425","name":"Molecular Drug Targets","call_identifier":"FWF"},{"name":"Synaptic communication in neuronal microcircuits","call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312"},{"grant_number":"LS18-022","name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","grant_number":"715508"},{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"},{"grant_number":"101026635","call_identifier":"H2020","name":"Synaptic computations of the hippocampal CA3 circuitry","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9"}],"page":"1051-1064","citation":{"chicago":"Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>.","apa":"Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2024). Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>","mla":"Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>, vol. 42, Springer Nature, 2024, pp. 1051–64, doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>.","ama":"Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. 2024;42:1051-1064. doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>","short":"J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology 42 (2024) 1051–1064.","ieee":"J. M. Michalska <i>et al.</i>, “Imaging brain tissue architecture across millimeter to nanometer scales,” <i>Nature Biotechnology</i>, vol. 42. Springer Nature, pp. 1051–1064, 2024.","ista":"Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2024. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 42, 1051–1064."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"yes","date_updated":"2026-10-21T08:36:20Z","_id":"14257","title":"Imaging brain tissue architecture across millimeter to nanometer scales","status":"public","author":[{"full_name":"Michalska, Julia M","orcid":"0000-0003-3862-1235","first_name":"Julia M","last_name":"Michalska","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87"},{"id":"46E28B80-F248-11E8-B48F-1D18A9856A87","last_name":"Lyudchik","first_name":"Julia","full_name":"Lyudchik, Julia"},{"id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Velicky","orcid":"0000-0002-2340-7431","full_name":"Velicky, Philipp"},{"full_name":"Korinkova, Hana","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed","first_name":"Hana","last_name":"Korinkova"},{"full_name":"Watson, Jake","orcid":"0000-0002-8698-3823","last_name":"Watson","first_name":"Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E"},{"full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","first_name":"Alban","last_name":"Cenameri"},{"first_name":"Christoph M","last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M"},{"full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207","first_name":"Nicole","last_name":"Amberg","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Venturino, Alessandro","orcid":"0000-0003-2356-9403","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","last_name":"Venturino","first_name":"Alessandro"},{"first_name":"Karl","last_name":"Roessler","full_name":"Roessler, Karl"},{"last_name":"Czech","first_name":"Thomas","full_name":"Czech, Thomas"},{"full_name":"Höftberger, Romana","last_name":"Höftberger","first_name":"Romana"},{"orcid":"0000-0001-8635-0877","full_name":"Siegert, Sandra","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","first_name":"Sandra","last_name":"Siegert"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"},{"first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"},{"first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973"}],"date_created":"2023-09-03T22:01:15Z","article_type":"original","type":"journal_article","oa_version":"Published Version","abstract":[{"text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.","lang":"eng"}]},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"yes","date_updated":"2026-10-21T08:35:21Z","DOAJ_listed":"1","citation":{"apa":"Früh, S., Boudkkazi, S., Koppensteiner, P., Sereikaite, V., Chen, L. Y., Fernandez-Fernandez, D., … Bettler, B. (2024). Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.adk5462\">https://doi.org/10.1126/sciadv.adk5462</a>","chicago":"Früh, Simon, Sami Boudkkazi, Peter Koppensteiner, Vita Sereikaite, Li Yuan Chen, Diego Fernandez-Fernandez, Pascal D. Rem, et al. “Monoallelic de Novo AJAP1 Loss-of- Function Variants Disrupt Trans-Synaptic Control of Neurotransmitter Release.” <i>Science Advances</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/sciadv.adk5462\">https://doi.org/10.1126/sciadv.adk5462</a>.","ista":"Früh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen LY, Fernandez-Fernandez D, Rem PD, Ulrich D, Schwenk J, Chen Z, Monnier EL, Fritzius T, Innocenti SM, Besseyrias V, Trovò L, Stawarski M, Argilli E, Sherr EH, Van Bon B, Kamsteeg EJ, Iascone M, Pilotta A, Cutrì MR, Azamian MS, Hernández-García A, Lalani SR, Rosenfeld JA, Zhao X, Vogel TP, Ona H, Scott DA, Scheiffele P, Strømgaard K, Tafti M, Gassmann M, Fakler B, Shigemoto R, Bettler B. 2024. Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release. Science Advances. 10(28), adk5462.","short":"S. Früh, S. Boudkkazi, P. Koppensteiner, V. Sereikaite, L.Y. Chen, D. Fernandez-Fernandez, P.D. Rem, D. Ulrich, J. Schwenk, Z. Chen, E.L. Monnier, T. Fritzius, S.M. Innocenti, V. Besseyrias, L. Trovò, M. Stawarski, E. Argilli, E.H. Sherr, B. Van Bon, E.J. Kamsteeg, M. Iascone, A. Pilotta, M.R. Cutrì, M.S. Azamian, A. Hernández-García, S.R. Lalani, J.A. Rosenfeld, X. Zhao, T.P. Vogel, H. Ona, D.A. Scott, P. Scheiffele, K. Strømgaard, M. Tafti, M. Gassmann, B. Fakler, R. Shigemoto, B. Bettler, Science Advances 10 (2024).","ieee":"S. Früh <i>et al.</i>, “Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release,” <i>Science Advances</i>, vol. 10, no. 28. American Association for the Advancement of Science, 2024.","ama":"Früh S, Boudkkazi S, Koppensteiner P, et al. Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release. <i>Science Advances</i>. 2024;10(28). doi:<a href=\"https://doi.org/10.1126/sciadv.adk5462\">10.1126/sciadv.adk5462</a>","mla":"Früh, Simon, et al. “Monoallelic de Novo AJAP1 Loss-of- Function Variants Disrupt Trans-Synaptic Control of Neurotransmitter Release.” <i>Science Advances</i>, vol. 10, no. 28, adk5462, American Association for the Advancement of Science, 2024, doi:<a href=\"https://doi.org/10.1126/sciadv.adk5462\">10.1126/sciadv.adk5462</a>."},"article_type":"original","oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"Adherens junction–associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid type B receptors (GBRs), which inhibit neurotransmitter release at most synapses in the brain. Here, we show that AJAP1 is selectively expressed in dendrites and trans-synaptically recruits GBRs to presynaptic sites of neurons expressing AJAP1. We have identified several monoallelic AJAP1 variants in individuals with epilepsy and/or neurodevelopmental disorders. Specifically, we show that the variant p.(W183C) lacks binding to GBRs, resulting in the inability to recruit them. Ultrastructural analysis revealed significantly decreased presynaptic GBR levels in Ajap1−/− and Ajap1W183C/+ mice. Consequently, these mice exhibited reduced GBR-mediated presynaptic inhibition at excitatory and inhibitory synapses, along with impaired synaptic plasticity. Our study reveals that AJAP1 enables the postsynaptic neuron to regulate the level of presynaptic GBR-mediated inhibition, supporting the clinical relevance of loss-of-function AJAP1 variants."}],"_id":"17280","title":"Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release","status":"public","author":[{"last_name":"Früh","first_name":"Simon","full_name":"Früh, Simon"},{"first_name":"Sami","last_name":"Boudkkazi","full_name":"Boudkkazi, Sami"},{"id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","last_name":"Koppensteiner","first_name":"Peter","full_name":"Koppensteiner, Peter","orcid":"0000-0002-3509-1948"},{"first_name":"Vita","last_name":"Sereikaite","full_name":"Sereikaite, Vita"},{"full_name":"Chen, Li Yuan","first_name":"Li Yuan","last_name":"Chen"},{"full_name":"Fernandez-Fernandez, Diego","last_name":"Fernandez-Fernandez","first_name":"Diego"},{"first_name":"Pascal D.","last_name":"Rem","full_name":"Rem, Pascal D."},{"last_name":"Ulrich","first_name":"Daniel","full_name":"Ulrich, Daniel"},{"last_name":"Schwenk","first_name":"Jochen","full_name":"Schwenk, Jochen"},{"first_name":"Ziyang","last_name":"Chen","full_name":"Chen, Ziyang"},{"full_name":"Monnier, Elodie Le","first_name":"Elodie Le","last_name":"Monnier"},{"full_name":"Fritzius, Thorsten","last_name":"Fritzius","first_name":"Thorsten"},{"first_name":"Sabrina M.","last_name":"Innocenti","full_name":"Innocenti, Sabrina M."},{"full_name":"Besseyrias, Valérie","last_name":"Besseyrias","first_name":"Valérie"},{"full_name":"Trovò, Luca","last_name":"Trovò","first_name":"Luca"},{"full_name":"Stawarski, Michal","last_name":"Stawarski","first_name":"Michal"},{"first_name":"Emanuela","last_name":"Argilli","full_name":"Argilli, Emanuela"},{"last_name":"Sherr","first_name":"Elliott H.","full_name":"Sherr, Elliott H."},{"full_name":"Van Bon, Bregje","last_name":"Van Bon","first_name":"Bregje"},{"last_name":"Kamsteeg","first_name":"Erik Jan","full_name":"Kamsteeg, Erik Jan"},{"first_name":"Maria","last_name":"Iascone","full_name":"Iascone, Maria"},{"first_name":"Alba","last_name":"Pilotta","full_name":"Pilotta, Alba"},{"full_name":"Cutrì, Maria R.","last_name":"Cutrì","first_name":"Maria R."},{"full_name":"Azamian, Mahshid S.","first_name":"Mahshid S.","last_name":"Azamian"},{"full_name":"Hernández-García, Andrés","last_name":"Hernández-García","first_name":"Andrés"},{"first_name":"Seema R.","last_name":"Lalani","full_name":"Lalani, Seema R."},{"full_name":"Rosenfeld, Jill A.","last_name":"Rosenfeld","first_name":"Jill A."},{"last_name":"Zhao","first_name":"Xiaonan","full_name":"Zhao, Xiaonan"},{"full_name":"Vogel, Tiphanie P.","first_name":"Tiphanie P.","last_name":"Vogel"},{"full_name":"Ona, Herda","first_name":"Herda","last_name":"Ona"},{"last_name":"Scott","first_name":"Daryl A.","full_name":"Scott, Daryl A."},{"full_name":"Scheiffele, Peter","first_name":"Peter","last_name":"Scheiffele"},{"full_name":"Strømgaard, Kristian","first_name":"Kristian","last_name":"Strømgaard"},{"first_name":"Mehdi","last_name":"Tafti","full_name":"Tafti, Mehdi"},{"full_name":"Gassmann, Martin","last_name":"Gassmann","first_name":"Martin"},{"full_name":"Fakler, Bernd","last_name":"Fakler","first_name":"Bernd"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Bernhard","last_name":"Bettler","full_name":"Bettler, Bernhard"}],"date_created":"2024-07-21T22:01:01Z","language":[{"iso":"eng"}],"OA_place":"publisher","OA_type":"gold","publication_identifier":{"eissn":["2375-2548"]},"acknowledgement":"Ajap1HA/HA and Ajap1W183C/+ mice were generated in collaboration with Pawel Pelczar at the center for transgenic models at the University of Basel, Switzerland. We thank the imaging core facility (IMCF, University of Basel) and in particular A. Ferrand for the technical assistance provided on the OMX 3D-SIM microscope.\r\nThis work was supported by a grant from the Swiss National Science Foundation (SNF) to B.B. (31003A-152970, 310030B-201291), an NIH grant to E.A. and E.H.S. (R01NS058721), DFG grants to B.F. (TRR 152 project ID 239283807, FA 332/15-1, 16-1), and grants to P.S. from AIMS-2-TRIALS, which are supported by the Innovative Medicines Initiatives from the European Commission joint undertaking under grant agreement No 777394.","publication":"Science Advances","issue":"28","scopus_import":"1","fulldoi":"https://doi.org/10.1126/sciadv.adk5462","das_tickbox":"1","date_published":"2024-07-12T00:00:00Z","file_date_updated":"2024-07-22T06:29:27Z","has_accepted_license":"1","article_processing_charge":"Yes","year":"2024","pmid":1,"quality_controlled":"1","publication_status":"published","intvolume":"        10","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["570"],"volume":10,"file":[{"file_name":"2024_ScienceAdv_Früh.pdf","date_updated":"2024-07-22T06:29:27Z","content_type":"application/pdf","file_size":7241489,"file_id":"17287","access_level":"open_access","relation":"main_file","creator":"dernst","success":1,"checksum":"9cbc4501fcd4ba1c0811fd244031422b","date_created":"2024-07-22T06:29:27Z"}],"doi":"10.1126/sciadv.adk5462","researchdata_availability":"yes (supplementary data)","article_number":"adk5462","isi":1,"external_id":{"pmid":["38985877"],"isi":["001280159000022"]},"department":[{"_id":"RySh"},{"_id":"PreCl"}],"month":"07","publisher":"American Association for the Advancement of Science","dataavailabilitystatement":"All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.","day":"12","oa":1},{"doi_confirm":"1","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"JoDa"}],"month":"12","day":"18","oa":1,"corr_author":"1","researchdata_availability":"no","doi":"10.15479/at:ista:18674","file":[{"file_name":"18122024_PhDthesis_corrected_final_pdfa.pdf","content_type":"application/pdf","date_updated":"2024-12-18T14:17:34Z","file_size":160536833,"file_id":"18675","access_level":"open_access","relation":"main_file","creator":"jlyudchi","success":1,"checksum":"1b42b8073e2bc09fc504da52372248c1","date_created":"2024-12-18T14:17:34Z"},{"file_id":"18676","file_name":"18122024_PhDthesis_corrected_final_JL_markup.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2024-12-18T14:41:53Z","file_size":99172203,"checksum":"b4da84624060745519723698f7ddf54b","date_created":"2024-12-18T14:21:06Z","access_level":"closed","relation":"source_file","creator":"jlyudchi"}],"publication_status":"published","year":"2024","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"ddc":["004"],"das_tickbox":"0","degree_awarded":"PhD","fulldoi":"https://doi.org/10.15479/at:ista:18674","acknowledged_ssus":[{"_id":"Bio"}],"has_accepted_license":"1","date_published":"2024-12-18T00:00:00Z","alternative_title":["ISTA Thesis"],"file_date_updated":"2024-12-18T14:41:53Z","article_processing_charge":"No","ec_funded":1,"publication_identifier":{"isbn":[" 978-3-99078-051-0"],"issn":["2663-337X"]},"language":[{"iso":"eng"}],"OA_place":"publisher","supervisor":[{"full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87"}],"type":"dissertation","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue requires volumetric imaging at nanoscale spatial resolution. While light microscopy excels at visualizing specific molecules and individual cells, achieving dense, synapse-level circuit reconstruction has not been possible with any light microscopy technique. Thus, the goal of my work was to develop image and data analysis pipelines for brain tissue visualization and reconstruction with light microscopy. To achieve dense circuit reconstruction with single-synapse resolution, I developed both conventional and deep-learning-based synapse detection algorithms, as well as connectivity analysis pipelines that integrate synapse detection with volumetric segmentation of brain tissue."}],"title":"Image analysis for brain tissue reconstruction with super-resolution light microscopy","_id":"18674","date_created":"2024-12-18T14:24:43Z","author":[{"full_name":"Lyudchik, Julia","id":"46E28B80-F248-11E8-B48F-1D18A9856A87","last_name":"Lyudchik","first_name":"Julia"}],"status":"public","date_updated":"2026-10-21T08:36:19Z","supplementarymaterial":"no","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"record":[{"status":"public","id":"11160","relation":"part_of_dissertation"},{"status":"public","id":"13267","relation":"part_of_dissertation"},{"id":"18677","relation":"part_of_dissertation","status":"public"},{"id":"14257","relation":"part_of_dissertation","status":"public"}]},"citation":{"ista":"Lyudchik J. 2024. Image analysis for brain tissue reconstruction with super-resolution light microscopy. Institute of Science and Technology Austria.","ieee":"J. Lyudchik, “Image analysis for brain tissue reconstruction with super-resolution light microscopy,” Institute of Science and Technology Austria, 2024.","short":"J. Lyudchik, Image Analysis for Brain Tissue Reconstruction with Super-Resolution Light Microscopy, Institute of Science and Technology Austria, 2024.","mla":"Lyudchik, Julia. <i>Image Analysis for Brain Tissue Reconstruction with Super-Resolution Light Microscopy</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:18674\">10.15479/at:ista:18674</a>.","ama":"Lyudchik J. Image analysis for brain tissue reconstruction with super-resolution light microscopy. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:18674\">10.15479/at:ista:18674</a>","apa":"Lyudchik, J. (2024). <i>Image analysis for brain tissue reconstruction with super-resolution light microscopy</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:18674\">https://doi.org/10.15479/at:ista:18674</a>","chicago":"Lyudchik, Julia. “Image Analysis for Brain Tissue Reconstruction with Super-Resolution Light Microscopy.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:18674\">https://doi.org/10.15479/at:ista:18674</a>."},"page":"217","project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program"}]},{"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-8979"],"eissn":["1089-7550"]},"ec_funded":1,"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 949120). This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria (ISTA) through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing Facility, and Lab Support Facility. The authors wish to thank Dmytro Rak and Juan Carlos Sobarzo for letting us use their equipment. The authors wish to thank the contributions of the whole Waitukaitis Group for useful discussions and feedback.","publication":"Journal of Applied Physics","issue":"4","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"yes","date_updated":"2026-10-21T08:39:25Z","related_material":{"record":[{"relation":"dissertation_contains","id":"22684","status":"public"}]},"project":[{"grant_number":"949120","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","call_identifier":"H2020","name":"Tribocharge: a multi-scale approach to an enduring problem in physics"}],"citation":{"chicago":"Lenton, Isaac C, Felix Pertl, Lubuna B Shafeek, and Scott R Waitukaitis. “Beyond the Blur: Using Experimentally Determined Point Spread Functions to Improve Scanning Kelvin Probe Imaging.” <i>Journal of Applied Physics</i>. AIP Publishing, 2024. <a href=\"https://doi.org/10.1063/5.0215151\">https://doi.org/10.1063/5.0215151</a>.","apa":"Lenton, I. C., Pertl, F., Shafeek, L. B., &#38; Waitukaitis, S. R. (2024). Beyond the blur: Using experimentally determined point spread functions to improve scanning Kelvin probe imaging. <i>Journal of Applied Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0215151\">https://doi.org/10.1063/5.0215151</a>","mla":"Lenton, Isaac C., et al. “Beyond the Blur: Using Experimentally Determined Point Spread Functions to Improve Scanning Kelvin Probe Imaging.” <i>Journal of Applied Physics</i>, vol. 136, no. 4, 045305, AIP Publishing, 2024, doi:<a href=\"https://doi.org/10.1063/5.0215151\">10.1063/5.0215151</a>.","ama":"Lenton IC, Pertl F, Shafeek LB, Waitukaitis SR. Beyond the blur: Using experimentally determined point spread functions to improve scanning Kelvin probe imaging. <i>Journal of Applied Physics</i>. 2024;136(4). doi:<a href=\"https://doi.org/10.1063/5.0215151\">10.1063/5.0215151</a>","short":"I.C. Lenton, F. Pertl, L.B. Shafeek, S.R. Waitukaitis, Journal of Applied Physics 136 (2024).","ista":"Lenton IC, Pertl F, Shafeek LB, Waitukaitis SR. 2024. Beyond the blur: Using experimentally determined point spread functions to improve scanning Kelvin probe imaging. Journal of Applied Physics. 136(4), 045305.","ieee":"I. C. Lenton, F. Pertl, L. B. Shafeek, and S. R. Waitukaitis, “Beyond the blur: Using experimentally determined point spread functions to improve scanning Kelvin probe imaging,” <i>Journal of Applied Physics</i>, vol. 136, no. 4. AIP Publishing, 2024."},"article_type":"original","type":"journal_article","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Scanning Kelvin probe microscopy (SKPM) is a powerful technique for investigating the electrostatic properties of material surfaces, enabling the imaging of variations in work function, topology, surface charge density, or combinations thereof. Regardless of the underlying signal source, SKPM results in a voltage image, which is spatially distorted due to the finite size of the probe, long-range electrostatic interactions, mechanical and electrical noise, and the finite response time of the electronics. In order to recover the underlying signal, it is necessary to deconvolve the measurement with an appropriate point spread function (PSF) that accounts the aforementioned distortions, but determining this PSF is difficult. Here, we describe how such PSFs can be determined experimentally and show how they can be used to recover the underlying information of interest. We first consider the physical principles that enable SKPM and discuss how these affect the system PSF. We then show how one can experimentally measure PSFs by looking at well-defined features, and that these compare well to simulated PSFs, provided scans are performed extremely slowly and carefully. Next, we work at realistic scan speeds and show that the idealized PSFs fail to capture temporal distortions in the scan direction. While simulating PSFs for these situations would be quite challenging, we show that measuring PSFs with similar scan conditions works well. Our approach clarifies the basic principles and inherent challenges to SKPM measurements and gives practical methods to improve results."}],"_id":"17373","title":"Beyond the blur: Using experimentally determined point spread functions to improve scanning Kelvin probe imaging","date_created":"2024-08-04T22:01:21Z","status":"public","author":[{"id":"a550210f-223c-11ec-8182-e2d45e817efb","last_name":"Lenton","first_name":"Isaac C","full_name":"Lenton, Isaac C","orcid":"0000-0002-5010-6984"},{"id":"6313aec0-15b2-11ec-abd3-ed67d16139af","last_name":"Pertl","first_name":"Felix","full_name":"Pertl, Felix","orcid":"0000-0003-0463-5794"},{"orcid":"0000-0001-7180-6050","full_name":"Shafeek, Lubuna B","last_name":"Shafeek","first_name":"Lubuna B","id":"3CD37A82-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Scott R","last_name":"Waitukaitis","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","full_name":"Waitukaitis, Scott R","orcid":"0000-0002-2299-3176"}],"volume":136,"file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-08-05T08:19:58Z","checksum":"6141d05cd68d540a7446dce9490975db","success":1,"file_size":2537502,"date_updated":"2024-08-05T08:19:58Z","content_type":"application/pdf","file_name":"2024_JourApplPhysics_Lenton.pdf","file_id":"17386"}],"doi":"10.1063/5.0215151","researchdata_availability":"upon request","article_number":"045305","isi":1,"external_id":{"isi":["001281681100003"]},"month":"07","department":[{"_id":"ScWa"},{"_id":"NanoFab"}],"publisher":"AIP Publishing","day":"28","dataavailabilitystatement":"The data that support the findings of this study are available from the corresponding author upon reasonable request.","corr_author":"1","oa":1,"fulldoi":"https://doi.org/10.1063/5.0215151","das_tickbox":"1","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"file_date_updated":"2024-08-05T08:19:58Z","date_published":"2024-07-28T00:00:00Z","has_accepted_license":"1","article_processing_charge":"No","year":"2024","quality_controlled":"1","publication_status":"published","intvolume":"       136","ddc":["530"],"tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"}},{"article_number":"102771","volume":5,"file":[{"success":1,"checksum":"3f0ee62e04bf5a44b45b035662826e95","date_created":"2024-07-16T11:50:03Z","access_level":"open_access","creator":"dernst","relation":"main_file","file_id":"17260","file_name":"2024_STARProtoc_Amberg.pdf","content_type":"application/pdf","date_updated":"2024-07-16T11:50:03Z","file_size":8871807}],"doi":"10.1016/j.xpro.2023.102771","researchdata_availability":"not applicable","dataavailabilitystatement":"No custom code or dataset was generated in this protocol.","day":"15","corr_author":"1","oa":1,"external_id":{"pmid":["38070137"]},"month":"03","department":[{"_id":"SiHi"}],"publisher":"Elsevier","file_date_updated":"2024-07-16T11:50:03Z","date_published":"2024-03-15T00:00:00Z","has_accepted_license":"1","keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Neuroscience"],"article_processing_charge":"Yes (in subscription journal)","fulldoi":"https://doi.org/10.1016/j.xpro.2023.102771","das_tickbox":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["570"],"pmid":1,"year":"2024","quality_controlled":"1","publication_status":"published","intvolume":"         5","language":[{"iso":"eng"}],"publication":"STAR Protocols","issue":"1","scopus_import":"1","acknowledgement":"This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging & Optics Facility (IOF) and Preclinical Facilities (PCF). N.A. received support from FWF Firnberg-Programme (T 1031). G.C. received support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 754411 as an ISTplus postdoctoral fellow. This work was also supported by IST Austria institutional funds, FWF SFB F78 to S.H., and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725780 LinPro) to S.H.","publication_identifier":{"issn":["2666-1667"]},"ec_funded":1,"project":[{"grant_number":"T01031","_id":"268F8446-B435-11E9-9278-68D0E5697425","name":"Role of Eed in neural stem cell lineage progression","call_identifier":"FWF"},{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","grant_number":"F7805"},{"grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020"}],"citation":{"apa":"Amberg, N., Cheung, G. T., &#38; Hippenmeyer, S. (2024). Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">https://doi.org/10.1016/j.xpro.2023.102771</a>","chicago":"Amberg, Nicole, Giselle T Cheung, and Simon Hippenmeyer. “Protocol for Sorting Cells from Mouse Brains Labeled with Mosaic Analysis with Double Markers by Flow Cytometry.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">https://doi.org/10.1016/j.xpro.2023.102771</a>.","ieee":"N. Amberg, G. T. Cheung, and S. Hippenmeyer, “Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry,” <i>STAR Protocols</i>, vol. 5, no. 1. Elsevier, 2024.","ista":"Amberg N, Cheung GT, Hippenmeyer S. 2024. Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. STAR Protocols. 5(1), 102771.","short":"N. Amberg, G.T. Cheung, S. Hippenmeyer, STAR Protocols 5 (2024).","mla":"Amberg, Nicole, et al. “Protocol for Sorting Cells from Mouse Brains Labeled with Mosaic Analysis with Double Markers by Flow Cytometry.” <i>STAR Protocols</i>, vol. 5, no. 1, 102771, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">10.1016/j.xpro.2023.102771</a>.","ama":"Amberg N, Cheung GT, Hippenmeyer S. Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. <i>STAR Protocols</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">10.1016/j.xpro.2023.102771</a>"},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-21T08:40:15Z","supplementarymaterial":"no","_id":"14683","title":"Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry","date_created":"2023-12-13T11:48:05Z","author":[{"last_name":"Amberg","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3183-8207","full_name":"Amberg, Nicole"},{"orcid":"0000-0001-8457-2572","full_name":"Cheung, Giselle T","id":"471195F6-F248-11E8-B48F-1D18A9856A87","first_name":"Giselle T","last_name":"Cheung"},{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061"}],"status":"public","article_type":"review","oa_version":"Published Version","type":"journal_article","abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables the generation of genetic mosaic tissue in mice and high-resolution phenotyping at the individual cell level. Here, we present a protocol for isolating MADM-labeled cells with high yield for downstream molecular analyses using fluorescence-activated cell sorting (FACS). We describe steps for generating MADM-labeled mice, perfusion, single-cell suspension, and debris removal. We then detail procedures for cell sorting by FACS and downstream analysis. This protocol is suitable for embryonic to adult mice.\r\nFor complete details on the use and execution of this protocol, please refer to Contreras et al. (2021).1","lang":"eng"}]},{"language":[{"iso":"eng"}],"OA_type":"gold","OA_place":"publisher","publication_identifier":{"eissn":["2666-1667"]},"acknowledgement":"We thank A. Heger for mouse breeding support. This work was supported by the Scientific Service Units of IST Austria through resources provided by the Imaging & Optics and Preclinical facilities. G.C. received funding from the European Commission (IST plus postdoctoral fellowship); S.H. was funded by ISTA institutional funds and the Austrian Science Fund Special Research Programmes (FWF SFB-F78 Neuro Stem Modulation).","ec_funded":1,"publication":"STAR Protocols","scopus_import":"1","issue":"3","supplementarymaterial":"yes","date_updated":"2026-10-21T09:14:52Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"apa":"Cheung, G. T., Streicher, C., &#38; Hippenmeyer, S. (2024). Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2024.103157\">https://doi.org/10.1016/j.xpro.2024.103157</a>","chicago":"Cheung, Giselle T, Carmen Streicher, and Simon Hippenmeyer. “Protocol for Quantitative Reconstruction of Cell Lineage Using Mosaic Analysis with Double Markers in Mice.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2024.103157\">https://doi.org/10.1016/j.xpro.2024.103157</a>.","ieee":"G. T. Cheung, C. Streicher, and S. Hippenmeyer, “Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice,” <i>STAR Protocols</i>, vol. 5, no. 3. Elsevier, 2024.","short":"G.T. Cheung, C. Streicher, S. Hippenmeyer, STAR Protocols 5 (2024).","ista":"Cheung GT, Streicher C, Hippenmeyer S. 2024. Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice. STAR Protocols. 5(3), 103157.","mla":"Cheung, Giselle T., et al. “Protocol for Quantitative Reconstruction of Cell Lineage Using Mosaic Analysis with Double Markers in Mice.” <i>STAR Protocols</i>, vol. 5, no. 3, 103157, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2024.103157\">10.1016/j.xpro.2024.103157</a>.","ama":"Cheung GT, Streicher C, Hippenmeyer S. Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice. <i>STAR Protocols</i>. 2024;5(3). doi:<a href=\"https://doi.org/10.1016/j.xpro.2024.103157\">10.1016/j.xpro.2024.103157</a>"},"project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","grant_number":"F7805"}],"type":"journal_article","oa_version":"Published Version","article_type":"original","abstract":[{"text":"The generation of diverse cell types during development is fundamental to brain\r\nfunctions. We outline a protocol to quantitatively assess the clonal output of individual neural progenitors using mosaic analysis with double markers (MADM) in\r\nmice. We first describe steps to acquire and reconstruct adult MADM clones in\r\nthe superior colliculus. Then we detail analysis pipelines to determine clonal\r\ncomposition and architecture. This protocol enables the buildup of quantitative\r\nframeworks of lineage progression with precise spatial resolution in the brain.\r\nFor complete details on the use and execution of this protocol, please refer to\r\nCheung et al.1","lang":"eng"}],"title":"Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice","_id":"17187","author":[{"orcid":"0000-0001-8457-2572","full_name":"Cheung, Giselle T","first_name":"Giselle T","last_name":"Cheung","id":"471195F6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Streicher, Carmen","last_name":"Streicher","first_name":"Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon"}],"status":"public","date_created":"2024-06-30T22:01:04Z","volume":5,"researchdata_availability":"yes (supplementary data)","doi":"10.1016/j.xpro.2024.103157","file":[{"file_id":"18809","file_size":5186071,"date_updated":"2025-01-09T12:12:40Z","content_type":"application/pdf","file_name":"2024_STARProtoc_Cheung.pdf","checksum":"d8a8cdba82a394e731aa699ace1ae433","date_created":"2025-01-09T12:12:40Z","success":1,"creator":"dernst","relation":"main_file","access_level":"open_access"}],"article_number":"103157","external_id":{"pmid":["38935508"]},"publisher":"Elsevier","department":[{"_id":"SiHi"}],"month":"09","dataavailabilitystatement":"No dataset was generated while composing this protocol. A FIJI macro script “3DSerialSectionAlignmentLineROI.ijm” and a Microsoft Excel template used in this protocol are provided as supplementary materials.","day":"20","corr_author":"1","oa":1,"das_tickbox":"1","fulldoi":"https://doi.org/10.1016/j.xpro.2024.103157","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"APC_amount":"804 EUR","has_accepted_license":"1","date_published":"2024-09-20T00:00:00Z","file_date_updated":"2025-01-09T12:12:40Z","article_processing_charge":"Yes","publication_status":"published","quality_controlled":"1","year":"2024","pmid":1,"intvolume":"         5","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"ddc":["570"]},{"APC_amount":"804 EUR","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"},{"_id":"PreCl"}],"fulldoi":"https://doi.org/10.1016/j.xpro.2024.103168","das_tickbox":"1","article_processing_charge":"Yes","date_published":"2024-09-20T00:00:00Z","file_date_updated":"2025-01-09T12:16:53Z","has_accepted_license":"1","intvolume":"         5","year":"2024","quality_controlled":"1","pmid":1,"publication_status":"published","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"ddc":["570"],"file":[{"file_size":6445556,"date_updated":"2025-01-09T12:16:53Z","content_type":"application/pdf","file_name":"2024_STARProtoc_Cheung2.pdf","file_id":"18810","relation":"main_file","creator":"dernst","access_level":"open_access","checksum":"464f52ecc6ec92f509552823bb82bf79","date_created":"2025-01-09T12:16:53Z","success":1}],"doi":"10.1016/j.xpro.2024.103168","researchdata_availability":"not applicable","volume":5,"article_number":"103168","month":"09","department":[{"_id":"SiHi"},{"_id":"PreCl"}],"publisher":"Elsevier","external_id":{"pmid":["38968076"]},"corr_author":"1","oa":1,"day":"20","dataavailabilitystatement":"No dataset or new code was generated while composing this protocol.","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"no","date_updated":"2026-10-21T09:15:51Z","project":[{"grant_number":"F7805","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression"}],"citation":{"ama":"Cheung GT, Pauler F, Koppensteiner P, Hippenmeyer S. Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq. <i>STAR Protocols</i>. 2024;5(3). doi:<a href=\"https://doi.org/10.1016/j.xpro.2024.103168\">10.1016/j.xpro.2024.103168</a>","mla":"Cheung, Giselle T., et al. “Protocol for Mapping Cell Lineage and Cell-Type Identity of Clonally-Related Cells in Situ Using MADM-CloneSeq.” <i>STAR Protocols</i>, vol. 5, no. 3, 103168, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2024.103168\">10.1016/j.xpro.2024.103168</a>.","ieee":"G. T. Cheung, F. Pauler, P. Koppensteiner, and S. Hippenmeyer, “Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq,” <i>STAR Protocols</i>, vol. 5, no. 3. Elsevier, 2024.","short":"G.T. Cheung, F. Pauler, P. Koppensteiner, S. Hippenmeyer, STAR Protocols 5 (2024).","ista":"Cheung GT, Pauler F, Koppensteiner P, Hippenmeyer S. 2024. Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq. STAR Protocols. 5(3), 103168.","chicago":"Cheung, Giselle T, Florian Pauler, Peter Koppensteiner, and Simon Hippenmeyer. “Protocol for Mapping Cell Lineage and Cell-Type Identity of Clonally-Related Cells in Situ Using MADM-CloneSeq.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2024.103168\">https://doi.org/10.1016/j.xpro.2024.103168</a>.","apa":"Cheung, G. T., Pauler, F., Koppensteiner, P., &#38; Hippenmeyer, S. (2024). Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2024.103168\">https://doi.org/10.1016/j.xpro.2024.103168</a>"},"abstract":[{"text":"The lineage relationship of clonally-related cells offers important insights into the ontogeny and cytoarchitecture of the brain in health and disease. Here, we provide a protocol to concurrently assess cell lineage relationship and cell-type identity among clonally-related cells in situ. We first describe the preparation and screening of acute brain slices containing clonally-related cells labeled using mosaic analysis with double markers (MADM). We then outline steps to collect RNA from individual cells for downstream applications and cell-type identification using RNA sequencing.\r\nFor complete details on the use and execution of this protocol, please refer to Cheung et al.\r\n1","lang":"eng"}],"article_type":"original","oa_version":"Published Version","type":"journal_article","author":[{"full_name":"Cheung, Giselle T","orcid":"0000-0001-8457-2572","last_name":"Cheung","first_name":"Giselle T","id":"471195F6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Pauler, Florian","orcid":"0000-0002-7462-0048","first_name":"Florian","last_name":"Pauler","id":"48EA0138-F248-11E8-B48F-1D18A9856A87"},{"id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Koppensteiner","orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter"},{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"status":"public","date_created":"2024-07-14T22:01:10Z","_id":"17232","title":"Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq","language":[{"iso":"eng"}],"OA_type":"gold","OA_place":"publisher","acknowledgement":"We thank R. Beattie and T. Asenov for designing and producing components of the multi-well slice recover chamber. We thank R. Shigemoto for providing equipment access. We thank C. Streicher and A. Heger for mouse breeding support. This work was supported by the Scientific Service Units of IST Austria through resources provided by the Imaging & Optics, Miba Machine Shop, and Preclinical facilities. G.C. received funding from the European Commission (IST plus postdoctoral fellowship) and S.H. was funded by ISTA institutional funds and the Austrian Science Fund Special Research Programmes (FWF SFB-F78 Neuro Stem Modulation).","publication_identifier":{"eissn":["2666-1667"]},"issue":"3","scopus_import":"1","publication":"STAR Protocols"},{"language":[{"iso":"eng"}],"acknowledgement":"We thank Florian Pauler for discussion and his expert technical support. This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging and Optics Facility (IOF) and Preclinical Facility (PCF). A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences.","publication_identifier":{"eissn":["2666-1667"]},"issue":"1","scopus_import":"1","publication":"STAR Protocols","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-21T09:13:13Z","supplementarymaterial":"no","project":[{"name":"Molecular mechanisms of radial neuronal migration","_id":"2625A13E-B435-11E9-9278-68D0E5697425","grant_number":"24812"}],"citation":{"chicago":"Hansen, Andi H, and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>.","apa":"Hansen, A. H., &#38; Hippenmeyer, S. (2024). Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>","ama":"Hansen AH, Hippenmeyer S. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>","mla":"Hansen, Andi H., and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>, vol. 5, no. 1, 102795, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>.","ieee":"A. H. Hansen and S. Hippenmeyer, “Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers,” <i>STAR Protocols</i>, vol. 5, no. 1. Elsevier, 2024.","ista":"Hansen AH, Hippenmeyer S. 2024. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. 5(1), 102795.","short":"A.H. Hansen, S. Hippenmeyer, STAR Protocols 5 (2024)."},"related_material":{"link":[{"url":"http://github.com/hippenmeyerlab","relation":"software"}]},"abstract":[{"lang":"eng","text":"Mosaic analysis with double markers (MADM) technology enables the sparse labeling of genetically defined neurons. We present a protocol for time-lapse imaging of cortical projection neuron migration in mice using MADM. We describe steps for the isolation, culturing, and 4D imaging of neuronal dynamics in MADM-labeled brain tissue. While this protocol is compatible with other single-cell labeling methods, the MADM approach provides a genetic platform for the functional assessment of cell-autonomous candidate gene function and the relative contribution of non-cell-autonomous effects.\r\n\r\nFor complete details on the use and execution of this protocol, please refer to Hansen et al. (2022),1 Contreras et al. (2021),2 and Amberg and Hippenmeyer (2021).3"}],"article_type":"review","oa_version":"Published Version","type":"journal_article","status":"public","date_created":"2024-01-14T23:00:56Z","author":[{"id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H","last_name":"Hansen","full_name":"Hansen, Andi H"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"}],"_id":"14794","title":"Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers","file":[{"file_id":"17264","file_size":3758943,"file_name":"2024_STARProtoc_Hansen.pdf","content_type":"application/pdf","date_updated":"2024-07-16T12:04:46Z","date_created":"2024-07-16T12:04:46Z","checksum":"4644d537451c5c114a9d7c7829b65bba","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access"}],"doi":"10.1016/j.xpro.2023.102795","researchdata_availability":"yes","volume":5,"article_number":"102795","department":[{"_id":"SiHi"}],"month":"03","publisher":"Elsevier","external_id":{"pmid":["38165800"]},"oa":1,"corr_author":"1","dataavailabilitystatement":"All scripts that were used to prepare data and figures for this manuscript are available via GitHub at http://github.com/hippenmeyerlab. GitHub DOI is listed in the key resources table. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","day":"15","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"fulldoi":"https://doi.org/10.1016/j.xpro.2023.102795","das_tickbox":"1","article_processing_charge":"Yes","date_published":"2024-03-15T00:00:00Z","file_date_updated":"2024-07-16T12:04:46Z","has_accepted_license":"1","intvolume":"         5","quality_controlled":"1","year":"2024","pmid":1,"publication_status":"published","ddc":["570"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"}},{"publication_identifier":{"eissn":["2470-0053"],"issn":["2470-0045"]},"scopus_import":"1","issue":"3","publication":"Physical Review E","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The tendency of materials to order in triboelectric series has prompted suggestions that contact electrification might have a single, unified underlying description. However, the possibility of “triboelectric cycles,” i.e., series that loop back onto themselves, is seemingly at odds with such a coherent description. In this work, we propose that if multiple charge carrying species are at play, both triboelectric series and cycles are possible. We show how series arise naturally if only a single charge carrier species is involved and if the driving mechanism is approach toward thermodynamic equilibrium, and simultaneously, that cycles are forbidden under such conditions. Suspecting multiple carriers might relax the situation, we affirm this is the case by explicit construction of a cycle involving two carriers, and then extend this to show how more complex cycles emerge. Our work highlights the importance of series and cycles towards determining the underlying mechanism(s) and carrier(s) in contact electrification."}],"type":"journal_article","oa_version":"None","article_type":"letter_note","status":"public","date_created":"2024-04-14T22:01:03Z","author":[{"full_name":"Sobarzo Ponce, Juan Carlos A","last_name":"Sobarzo Ponce","first_name":"Juan Carlos A","id":"4B807D68-AE37-11E9-AC72-31CAE5697425"},{"first_name":"Scott R","last_name":"Waitukaitis","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2299-3176","full_name":"Waitukaitis, Scott R"}],"title":"Multiple charge carrier species as a possible cause for triboelectric cycles","_id":"15322","date_updated":"2026-10-21T08:38:31Z","supplementarymaterial":"no","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ieee":"J. C. A. Sobarzo Ponce and S. R. Waitukaitis, “Multiple charge carrier species as a possible cause for triboelectric cycles,” <i>Physical Review E</i>, vol. 109, no. 3. American Physical Society, 2024.","ista":"Sobarzo Ponce JCA, Waitukaitis SR. 2024. Multiple charge carrier species as a possible cause for triboelectric cycles. Physical Review E. 109(3), L032108.","short":"J.C.A. Sobarzo Ponce, S.R. Waitukaitis, Physical Review E 109 (2024).","mla":"Sobarzo Ponce, Juan Carlos A., and Scott R. Waitukaitis. “Multiple Charge Carrier Species as a Possible Cause for Triboelectric Cycles.” <i>Physical Review E</i>, vol. 109, no. 3, L032108, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/PhysRevE.109.L032108\">10.1103/PhysRevE.109.L032108</a>.","ama":"Sobarzo Ponce JCA, Waitukaitis SR. Multiple charge carrier species as a possible cause for triboelectric cycles. <i>Physical Review E</i>. 2024;109(3). doi:<a href=\"https://doi.org/10.1103/PhysRevE.109.L032108\">10.1103/PhysRevE.109.L032108</a>","apa":"Sobarzo Ponce, J. C. A., &#38; Waitukaitis, S. R. (2024). Multiple charge carrier species as a possible cause for triboelectric cycles. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.109.L032108\">https://doi.org/10.1103/PhysRevE.109.L032108</a>","chicago":"Sobarzo Ponce, Juan Carlos A, and Scott R Waitukaitis. “Multiple Charge Carrier Species as a Possible Cause for Triboelectric Cycles.” <i>Physical Review E</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/PhysRevE.109.L032108\">https://doi.org/10.1103/PhysRevE.109.L032108</a>."},"related_material":{"record":[{"relation":"dissertation_contains","id":"20203","status":"public"}]},"publisher":"American Physical Society","department":[{"_id":"ScWa"}],"month":"03","external_id":{"pmid":["38632754"],"isi":["001199745200004"]},"corr_author":"1","day":"29","researchdata_availability":"no","doi":"10.1103/PhysRevE.109.L032108","volume":109,"isi":1,"article_number":"L032108","intvolume":"       109","publication_status":"published","pmid":1,"year":"2024","quality_controlled":"1","das_tickbox":"0","fulldoi":"https://doi.org/10.1103/PhysRevE.109.L032108","article_processing_charge":"No","date_published":"2024-03-29T00:00:00Z"},{"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"acknowledgement":"We thank Bernhardt Steinwender, Jorgen Eilenberg, and Nicolai V. Meyling for the fungal strains. We further thank Chengshu Wang for providing the short sequencing reads for M. guizhouense ARESF977 he used for his published genome assembly, and Kristian Ullrich for help in the bioinformatics analysis for methylation pattern in Nanopore reads, and the VBC and the Max Planck Society for the use of their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg for discussion, and Tal Dagan and Jens Rolff for comments on a previous version of the manuscript. Fig. 1A was created with BioRender.com. This study received funding by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German Research Foundation (DFG grant HA9263/1-1) to M.H.","ec_funded":1,"publication":"Proceedings of the National Academy of Sciences of the United States of America","scopus_import":"1","issue":"11","language":[{"iso":"eng"}],"OA_type":"hybrid","OA_place":"publisher","oa_version":"Published Version","type":"journal_article","article_type":"original","abstract":[{"lang":"eng","text":"Entire chromosomes are typically only transmitted vertically from one generation to the next. The horizontal transfer of such chromosomes has long been considered improbable, yet gained recent support in several pathogenic fungi where it may affect the fitness or host specificity. To date, it is unknown how these transfers occur, how common they are and whether they can occur between different species. In this study, we show multiple independent instances of horizontal transfers of the same accessory chromosome between two distinct strains of the asexual entomopathogenic fungus<jats:italic>Metarhizium robertsii</jats:italic>during experimental co-infection of its insect host, the Argentine ant. Notably, only the one chromosome – but no other – was transferred from the donor to the recipient strain. The recipient strain, now harboring the accessory chromosome, exhibited a competitive advantage under certain host conditions. By phylogenetic analysis we further demonstrate that the same accessory chromosome was horizontally transferred in a natural environment between<jats:italic>M. robertsii</jats:italic>and another congeneric insect pathogen,<jats:italic>M. guizhouense</jats:italic>. Hence horizontal chromosome transfer is not limited to the observed frequent events within species during experimental infections but also occurs naturally across species. The transferred accessory chromosome contains genes that might be involved in its preferential horizontal transfer, encoding putative histones and histone-modifying enzymes, but also putative virulence factors that may support its establishment. Our study reveals that both intra- and interspecies horizontal transfer of entire chromosomes is more frequent than previously assumed, likely representing a not uncommon mechanism for gene exchange.</jats:p><jats:sec><jats:title>Significance Statement</jats:title><jats:p>The enormous success of bacterial pathogens has been attributed to their ability to exchange genetic material between one another. Similarly, in eukaryotes, horizontal transfer of genetic material allowed the spread of virulence factors across species. The horizontal transfer of whole chromosomes could be an important pathway for such exchange of genetic material, but little is known about the origin of transferable chromosomes and how frequently they are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes that are non-essential but may provide fitness benefits - is common during fungal co-infections and is even possible between distant pathogenic species, highlighting the importance of horizontal gene transfer via chromosome transfer also for the evolution and function of eukaryotic pathogens."}],"title":"Frequent horizontal chromosome transfer between asexual fungal insect pathogens","_id":"14478","status":"public","author":[{"first_name":"Michael","last_name":"Habig","full_name":"Habig, Michael"},{"full_name":"Grasse, Anna V","first_name":"Anna V","last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Judith","last_name":"Müller","full_name":"Müller, Judith"},{"full_name":"Stukenbrock, Eva H.","first_name":"Eva H.","last_name":"Stukenbrock"},{"last_name":"Leitner","first_name":"Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","full_name":"Leitner, Hanna"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer"}],"date_created":"2023-10-31T13:30:00Z","supplementarymaterial":"yes","date_updated":"2026-10-21T10:25:57Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ista":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. 2024. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings of the National Academy of Sciences of the United States of America. 121(11), e2316284121.","ieee":"M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer, “Frequent horizontal chromosome transfer between asexual fungal insect pathogens,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 11. National Academy of Sciences, 2024.","short":"M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","mla":"Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 11, e2316284121, National Academy of Sciences, 2024, doi:<a href=\"https://doi.org/10.1073/pnas.2316284121\">10.1073/pnas.2316284121</a>.","ama":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2024;121(11). doi:<a href=\"https://doi.org/10.1073/pnas.2316284121\">10.1073/pnas.2316284121</a>","apa":"Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., &#38; Cremer, S. (2024). Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2316284121\">https://doi.org/10.1073/pnas.2316284121</a>","chicago":"Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2024. <a href=\"https://doi.org/10.1073/pnas.2316284121\">https://doi.org/10.1073/pnas.2316284121</a>."},"project":[{"grant_number":"771402","call_identifier":"H2020","name":"Epidemics in ant societies on a chip","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"}],"external_id":{"isi":["001207630200005"],"pmid":["38442176"]},"publisher":"National Academy of Sciences","department":[{"_id":"SyCr"}],"month":"03","day":"12","dataavailabilitystatement":"Sequencing reads have been deposited in the Sequence Read Archive and are available under the BioProject PRJNA1017668 (67). The Nanopore-based assemblies and Gene annotations were deposited at NCBI under the BioProjects PRJNA1015426 (68), PRJNA1015429 (69), and PRJNA1015431 (70). All source data for the figures are given in Datasets S3–S14. Note that of the total of 2,626 spore-clones shown in Fig. 2, 872 had been produced, analyzed for strain identity and previously published in Stock et al. (35). The production and strain-identification of the remaining 1,754 spore-derived clones, as well as the presence/absence characterization of chrA within all 883 R3 spore-clones were performed in this study.","oa":1,"corr_author":"1","volume":121,"doi":"10.1073/pnas.2316284121","researchdata_availability":"yes","file":[{"checksum":"f5e871db617b682edc71fcd08670dc81","date_created":"2024-03-19T09:02:57Z","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access","file_id":"15124","file_size":5750361,"date_updated":"2024-03-19T09:02:57Z","content_type":"application/pdf","file_name":"2024_PNAS_Habig.pdf"}],"isi":1,"article_number":"e2316284121","publication_status":"published","year":"2024","quality_controlled":"1","pmid":1,"intvolume":"       121","ddc":["570"],"tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"das_tickbox":"1","fulldoi":"https://doi.org/10.1073/pnas.2316284121","APC_amount":"3040,36 EUR","has_accepted_license":"1","date_published":"2024-03-12T00:00:00Z","file_date_updated":"2024-03-19T09:02:57Z","article_processing_charge":"Yes (in subscription journal)"},{"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["570"],"pmid":1,"quality_controlled":"1","year":"2024","publication_status":"published","intvolume":"       112","date_published":"2024-01-17T00:00:00Z","file_date_updated":"2024-02-06T13:56:15Z","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","fulldoi":"https://doi.org/10.1016/j.neuron.2023.11.009","das_tickbox":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"PreCl"}],"day":"17","dataavailabilitystatement":"All data generated and analyzed in this study are included in the paper and/or supplementary materials. Raw sequencing data has been deposited at Gene Expression Omnibus (GEO). All scripts that were used to prepare data and figures for this manuscript are available via GitHub at https://github.com/fpauler. Accession numbers and github DOI are listed in the key resources table. Files for 3D printing of acute slice recovery chamber (3D model 361319) are deposited to https://www.printables.com.","oa":1,"corr_author":"1","external_id":{"pmid":["38096816"],"isi":["001163937900001"]},"month":"01","department":[{"_id":"SiHi"},{"_id":"RySh"}],"publisher":"Elsevier","isi":1,"volume":112,"file":[{"file_id":"14944","file_size":5942467,"date_updated":"2024-02-06T13:56:15Z","content_type":"application/pdf","file_name":"2024_Neuron_Cheung.pdf","checksum":"32b3788f7085cf44a84108d8faaff3ce","date_created":"2024-02-06T13:56:15Z","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access"}],"doi":"10.1016/j.neuron.2023.11.009","researchdata_availability":"yes","_id":"12875","title":"Multipotent progenitors instruct ontogeny of the superior colliculus","date_created":"2023-04-27T09:41:48Z","author":[{"id":"471195F6-F248-11E8-B48F-1D18A9856A87","first_name":"Giselle T","last_name":"Cheung","full_name":"Cheung, Giselle T","orcid":"0000-0001-8457-2572"},{"full_name":"Pauler, Florian","orcid":"0000-0002-7462-0048","first_name":"Florian","last_name":"Pauler","id":"48EA0138-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter","last_name":"Koppensteiner","first_name":"Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Krausgruber, Thomas","last_name":"Krausgruber","first_name":"Thomas"},{"id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","last_name":"Streicher","first_name":"Carmen","full_name":"Streicher, Carmen"},{"full_name":"Schrammel, Martin","id":"f13e7cae-e8bd-11ed-841a-96dedf69f46d","last_name":"Schrammel","first_name":"Martin"},{"full_name":"Özgen, Natalie Y","last_name":"Özgen","first_name":"Natalie Y","id":"e68ece33-f6e0-11ea-865d-ae1031dcc090"},{"first_name":"Alexis","last_name":"Ivec","id":"1d144691-e8be-11ed-9b33-bdd3077fad4c","full_name":"Ivec, Alexis"},{"last_name":"Bock","first_name":"Christoph","full_name":"Bock, Christoph"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"first_name":"Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"status":"public","article_type":"original","oa_version":"Published Version","type":"journal_article","abstract":[{"text":"The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. However, the developmental principles directing the generation of SC cell-type diversity are not understood. Here, we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic mosaic analysis with double markers (MADM)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally related cell lineages revealed that radial glial progenitors (RGPs) in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at the single-RGP/-cell level of the mammalian SC ontogeny.","lang":"eng"}],"related_material":{"link":[{"url":"https://ista.ac.at/en/news/the-pedigree-of-brain-cells/","relation":"press_release","description":"News on ISTA Website"}]},"project":[{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","grant_number":"F7805"}],"page":"230-246.e11","citation":{"apa":"Cheung, G. T., Pauler, F., Koppensteiner, P., Krausgruber, T., Streicher, C., Schrammel, M., … Hippenmeyer, S. (2024). Multipotent progenitors instruct ontogeny of the superior colliculus. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2023.11.009\">https://doi.org/10.1016/j.neuron.2023.11.009</a>","chicago":"Cheung, Giselle T, Florian Pauler, Peter Koppensteiner, Thomas Krausgruber, Carmen Streicher, Martin Schrammel, Natalie Y Özgen, et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” <i>Neuron</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.neuron.2023.11.009\">https://doi.org/10.1016/j.neuron.2023.11.009</a>.","ieee":"G. T. Cheung <i>et al.</i>, “Multipotent progenitors instruct ontogeny of the superior colliculus,” <i>Neuron</i>, vol. 112, no. 2. Elsevier, p. 230–246.e11, 2024.","ista":"Cheung GT, Pauler F, Koppensteiner P, Krausgruber T, Streicher C, Schrammel M, Özgen NY, Ivec A, Bock C, Shigemoto R, Hippenmeyer S. 2024. Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. 112(2), 230–246.e11.","short":"G.T. Cheung, F. Pauler, P. Koppensteiner, T. Krausgruber, C. Streicher, M. Schrammel, N.Y. Özgen, A. Ivec, C. Bock, R. Shigemoto, S. Hippenmeyer, Neuron 112 (2024) 230–246.e11.","ama":"Cheung GT, Pauler F, Koppensteiner P, et al. Multipotent progenitors instruct ontogeny of the superior colliculus. <i>Neuron</i>. 2024;112(2):230-246.e11. doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.11.009\">10.1016/j.neuron.2023.11.009</a>","mla":"Cheung, Giselle T., et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” <i>Neuron</i>, vol. 112, no. 2, Elsevier, 2024, p. 230–246.e11, doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.11.009\">10.1016/j.neuron.2023.11.009</a>."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"yes","date_updated":"2026-10-21T09:51:58Z","publication":"Neuron","issue":"2","scopus_import":"1","publication_identifier":{"issn":["0896-6273"]},"acknowledgement":"We thank Liqun Luo for his continued support, for providing essential resources for generating Fzd10-CreER mice which were generated in his laboratory, and for comments on the manuscript; W. Zhong for providing Nestin-Cre transgenic mouse line for this study; A. Heger for mouse colony management; R. Beattie and T. Asenov for designing and producing components of acute slice recovery chamber for MADM-CloneSeq experiments; and K. Leopold, J. Rodarte and N. Amberg for initial experiments, technical support and/or assistance. This study was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging & Optics Facility (IOF), Laboratory Support Facility (LSF), Miba Machine Shop, and Pre-clinical Facility (PCF). G.C. received funding from European Commission (IST plus postdoctoral fellowship). This work was supported by ISTA institutional\r\nfunds; the Austrian Science Fund Special Research Programmes (FWF SFB F78 Neuro Stem Modulation) to S.H. ","language":[{"iso":"eng"}]},{"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["540"],"publication_status":"published","pmid":1,"quality_controlled":"1","year":"2024","intvolume":"         7","has_accepted_license":"1","date_published":"2024-01-22T00:00:00Z","file_date_updated":"2024-07-16T11:59:24Z","article_processing_charge":"Yes (in subscription journal)","keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"das_tickbox":"0","fulldoi":"https://doi.org/10.1021/acsaem.3c02223","main_file_link":[{"url":"https://doi.org/10.1021/acsaem.3c02223","open_access":"1"}],"day":"22","oa":1,"external_id":{"pmid":["38273966"],"isi":["001146733200001"]},"publisher":"American Chemical Society","department":[{"_id":"StFr"}],"month":"01","isi":1,"volume":7,"researchdata_availability":"no","doi":"10.1021/acsaem.3c02223","file":[{"file_id":"17262","date_updated":"2024-07-16T11:59:24Z","content_type":"application/pdf","file_name":"2024_ACSAppElecMaterials_Jethwa.pdf","file_size":5607177,"success":1,"date_created":"2024-07-16T11:59:24Z","checksum":"2841e86a041d249ac0df2531b7f9aec1","access_level":"open_access","creator":"dernst","relation":"main_file"}],"title":"Exploring the landscape of heterocyclic quinones for redox flow batteries","_id":"14733","date_created":"2024-01-05T09:20:48Z","author":[{"first_name":"Rajesh B","last_name":"Jethwa","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f","orcid":"0000-0002-0404-4356","full_name":"Jethwa, Rajesh B"},{"first_name":"Dominic","last_name":"Hey","full_name":"Hey, Dominic"},{"full_name":"Kerber, Rachel N.","last_name":"Kerber","first_name":"Rachel N."},{"first_name":"Andrew D.","last_name":"Bond","full_name":"Bond, Andrew D."},{"full_name":"Wright, Dominic S.","first_name":"Dominic S.","last_name":"Wright"},{"full_name":"Grey, Clare P.","first_name":"Clare P.","last_name":"Grey"}],"status":"public","type":"journal_article","oa_version":"Published Version","article_type":"original","abstract":[{"text":"Redox flow batteries (RFBs) rely on the development of cheap, highly soluble, and high-energy-density electrolytes. Several candidate quinones have already been investigated in the literature as two-electron anolytes or catholytes, benefiting from fast kinetics, high tunability, and low cost. Here, an investigation of nitrogen-rich fused heteroaromatic quinones was carried out to explore avenues for electrolyte development. These quinones were synthesized and screened by using electrochemical techniques. The most promising candidate, 4,8-dioxo-4,8-dihydrobenzo[1,2-d:4,5-d′]bis([1,2,3]triazole)-1,5-diide (−0.68 V(SHE)), was tested in both an asymmetric and symmetric full-cell setup resulting in capacity fade rates of 0.35% per cycle and 0.0124% per cycle, respectively. In situ ultraviolet-visible spectroscopy (UV–Vis), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR) spectroscopies were used to investigate the electrochemical stability of the charged species during operation. UV–Vis spectroscopy, supported by density functional theory (DFT) modeling, reaffirmed that the two-step charging mechanism observed during battery operation consisted of two, single-electron transfers. The radical concentration during battery operation and the degree of delocalization of the unpaired electron were quantified with NMR and EPR spectroscopy.","lang":"eng"}],"citation":{"apa":"Jethwa, R. B., Hey, D., Kerber, R. N., Bond, A. D., Wright, D. S., &#38; Grey, C. P. (2024). Exploring the landscape of heterocyclic quinones for redox flow batteries. <i>ACS Applied Energy Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsaem.3c02223\">https://doi.org/10.1021/acsaem.3c02223</a>","chicago":"Jethwa, Rajesh B, Dominic Hey, Rachel N. Kerber, Andrew D. Bond, Dominic S. Wright, and Clare P. Grey. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” <i>ACS Applied Energy Materials</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/acsaem.3c02223\">https://doi.org/10.1021/acsaem.3c02223</a>.","ieee":"R. B. Jethwa, D. Hey, R. N. Kerber, A. D. Bond, D. S. Wright, and C. P. Grey, “Exploring the landscape of heterocyclic quinones for redox flow batteries,” <i>ACS Applied Energy Materials</i>, vol. 7, no. 2. American Chemical Society, pp. 414–426, 2024.","ista":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. 2024. Exploring the landscape of heterocyclic quinones for redox flow batteries. ACS Applied Energy Materials. 7(2), 414–426.","short":"R.B. Jethwa, D. Hey, R.N. Kerber, A.D. Bond, D.S. Wright, C.P. Grey, ACS Applied Energy Materials 7 (2024) 414–426.","mla":"Jethwa, Rajesh B., et al. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” <i>ACS Applied Energy Materials</i>, vol. 7, no. 2, American Chemical Society, 2024, pp. 414–26, doi:<a href=\"https://doi.org/10.1021/acsaem.3c02223\">10.1021/acsaem.3c02223</a>.","ama":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. Exploring the landscape of heterocyclic quinones for redox flow batteries. <i>ACS Applied Energy Materials</i>. 2024;7(2):414-426. doi:<a href=\"https://doi.org/10.1021/acsaem.3c02223\">10.1021/acsaem.3c02223</a>"},"page":"414-426","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","grant_number":"101034413"}],"date_updated":"2026-10-21T09:53:30Z","supplementarymaterial":"yes","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"ACS Applied Energy Materials","scopus_import":"1","issue":"2","publication_identifier":{"eissn":["2574-0962"]},"ec_funded":1,"language":[{"iso":"eng"}]},{"has_accepted_license":"1","date_published":"2024-07-08T00:00:00Z","file_date_updated":"2024-07-16T11:54:46Z","article_processing_charge":"Yes (via OA deal)","keyword":["General Chemistry","Catalysis"],"das_tickbox":"0","fulldoi":"https://doi.org/10.1002/anie.202316476","ddc":["540"],"tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication_status":"published","year":"2024","pmid":1,"quality_controlled":"1","intvolume":"        63","isi":1,"article_number":"e202316476","volume":63,"doi":"10.1002/anie.202316476","researchdata_availability":"no","file":[{"file_id":"17261","file_size":4766445,"content_type":"application/pdf","date_updated":"2024-07-16T11:54:46Z","file_name":"2024_AngChemieInt_Jethwa.pdf","date_created":"2024-07-16T11:54:46Z","checksum":"fe2c23454279eb9d76ed6ca9970c21c7","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access"}],"day":"08","corr_author":"1","oa":1,"external_id":{"isi":["001241932700001"],"pmid":["38095355"]},"publisher":"Wiley","month":"07","department":[{"_id":"StFr"},{"_id":"GradSch"}],"related_material":{"record":[{"status":"public","id":"20607","relation":"dissertation_contains"}]},"citation":{"apa":"Jethwa, R. B., Mondal, S., Pant, B., &#38; Freunberger, S. A. (2024). To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202316476\">https://doi.org/10.1002/anie.202316476</a>","chicago":"Jethwa, Rajesh B, Soumyadip Mondal, Bhargavi Pant, and Stefan Alexander Freunberger. “To DISP or Not? The Far‐reaching Reaction Mechanisms Underpinning Lithium‐air Batteries.” <i>Angewandte Chemie International Edition</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/anie.202316476\">https://doi.org/10.1002/anie.202316476</a>.","ista":"Jethwa RB, Mondal S, Pant B, Freunberger SA. 2024. To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. Angewandte Chemie International Edition. 63(28), e202316476.","ieee":"R. B. Jethwa, S. Mondal, B. Pant, and S. A. Freunberger, “To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries,” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 28. Wiley, 2024.","short":"R.B. Jethwa, S. Mondal, B. Pant, S.A. Freunberger, Angewandte Chemie International Edition 63 (2024).","mla":"Jethwa, Rajesh B., et al. “To DISP or Not? The Far‐reaching Reaction Mechanisms Underpinning Lithium‐air Batteries.” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 28, e202316476, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/anie.202316476\">10.1002/anie.202316476</a>.","ama":"Jethwa RB, Mondal S, Pant B, Freunberger SA. To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. <i>Angewandte Chemie International Edition</i>. 2024;63(28). doi:<a href=\"https://doi.org/10.1002/anie.202316476\">10.1002/anie.202316476</a>"},"project":[{"grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"date_updated":"2026-10-21T10:25:05Z","supplementarymaterial":"no","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries","_id":"14687","author":[{"id":"4cc538d5-803f-11ed-ab7e-8139573aad8f","last_name":"Jethwa","first_name":"Rajesh B","orcid":"0000-0002-0404-4356","full_name":"Jethwa, Rajesh B"},{"last_name":"Mondal","first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","full_name":"Mondal, Soumyadip"},{"full_name":"Pant, Bhargavi","first_name":"Bhargavi","last_name":"Pant","id":"50c64d4d-eb97-11eb-a6c2-d33e5e14f112"},{"orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"}],"date_created":"2023-12-15T16:10:13Z","status":"public","oa_version":"Published Version","type":"journal_article","article_type":"review","abstract":[{"text":"The short history of research on Li-O2 batteries has seen a remarkable number of mechanistic U-turns over the years. From the initial use of carbonate electrolytes, that were then found to be entirely unsuitable, to the belief that (su)peroxide was solely responsible for degradation, before the more reactive singlet oxygen was found to form, to the hypothesis that capacity depends on a competing surface/solution mechanism before a practically exclusive solution mechanism was identified. Herein, we argue for an ever-fresh look at the reported data without bias towards supposedly established explanations. We explain how the latest findings on rate and capacity limits, as well as the origin of side reactions, are connected via the disproportionation (DISP) step in the (dis)charge mechanism. Therefrom, directions emerge for the design of electrolytes and mediators on how to suppress side reactions and to enable high rate and high reversible capacity.","lang":"eng"}],"language":[{"iso":"eng"}],"publication":"Angewandte Chemie International Edition","scopus_import":"1","issue":"28","acknowledgement":"S.A.F. is indebted to ISTA for support. R.B.J. thanks the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413 for funding. B.P. thanks Alistore ERI for providing a PhD scholarship.","publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"ec_funded":1},{"publication_identifier":{"eissn":["1364-5498"],"issn":["1359-6640"]},"publication":"Faraday Discussions","scopus_import":"1","language":[{"iso":"eng"}],"article_type":"original","type":"journal_article","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Singlet oxygen (1O2) formation is now recognised as a key aspect of non-aqueous oxygen redox chemistry. For identifying 1O2, chemical trapping via 9,10-dimethylanthracene (DMA) to form the endoperoxide (DMA-O2) has become the mainstay method due to its sensitivity, selectivity, and ease of use. While DMA has been shown to be selective for 1O2, rather than forming DMA-O2 with a wide variety of potentially reactive O-containing species, false positives might hypothetically be obtained in the presence of previously overlooked species. Here, we first give unequivocal direct spectroscopic proof by the 1O2-specific near infrared (NIR) emission at 1270 nm for the previously proposed 1O2 formation pathways, which centre around superoxide disproportionation. We then show that peroxocarbonates, common intermediates in metal-O2 and metal carbonate electrochemistry, do not produce false-positive DMA-O2. Moreover, we identify a previously unreported 1O2-forming pathway through the reaction of CO2 with superoxide. Overall, we give unequivocal proof for 1O2 formation in non-aqueous oxygen redox and show that chemical trapping with DMA is a reliable method to assess 1O2 formation."}],"_id":"13044","title":"Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes","author":[{"full_name":"Mondal, Soumyadip","last_name":"Mondal","first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48"},{"full_name":"Jethwa, Rajesh B","orcid":"0000-0002-0404-4356","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f","first_name":"Rajesh B","last_name":"Jethwa"},{"id":"50c64d4d-eb97-11eb-a6c2-d33e5e14f112","last_name":"Pant","first_name":"Bhargavi","full_name":"Pant, Bhargavi"},{"full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","last_name":"Hauschild","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"}],"status":"public","date_created":"2023-05-22T06:53:34Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-21T10:24:27Z","supplementarymaterial":"yes","related_material":{"record":[{"status":"public","id":"20607","relation":"dissertation_contains"}]},"license":"https://creativecommons.org/licenses/by-nc/3.0/","citation":{"apa":"Mondal, S., Jethwa, R. B., Pant, B., Hauschild, R., &#38; Freunberger, S. A. (2024). Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd00088e\">https://doi.org/10.1039/d3fd00088e</a>","chicago":"Mondal, Soumyadip, Rajesh B Jethwa, Bhargavi Pant, Robert Hauschild, and Stefan Alexander Freunberger. “Singlet Oxygen in Non-Aqueous Oxygen Redox: Direct Spectroscopic Evidence for Formation Pathways and Reliability of Chemical Probes.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d3fd00088e\">https://doi.org/10.1039/d3fd00088e</a>.","ieee":"S. Mondal, R. B. Jethwa, B. Pant, R. Hauschild, and S. A. Freunberger, “Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes,” <i>Faraday Discussions</i>, vol. 248. Royal Society of Chemistry, pp. 175–189, 2024.","short":"S. Mondal, R.B. Jethwa, B. Pant, R. Hauschild, S.A. Freunberger, Faraday Discussions 248 (2024) 175–189.","ista":"Mondal S, Jethwa RB, Pant B, Hauschild R, Freunberger SA. 2024. Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. Faraday Discussions. 248, 175–189.","ama":"Mondal S, Jethwa RB, Pant B, Hauschild R, Freunberger SA. Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. <i>Faraday Discussions</i>. 2024;248:175-189. doi:<a href=\"https://doi.org/10.1039/d3fd00088e\">10.1039/d3fd00088e</a>","mla":"Mondal, Soumyadip, et al. “Singlet Oxygen in Non-Aqueous Oxygen Redox: Direct Spectroscopic Evidence for Formation Pathways and Reliability of Chemical Probes.” <i>Faraday Discussions</i>, vol. 248, Royal Society of Chemistry, 2024, pp. 175–89, doi:<a href=\"https://doi.org/10.1039/d3fd00088e\">10.1039/d3fd00088e</a>."},"page":"175-189","external_id":{"isi":["001070423500001"],"pmid":["37750344"]},"department":[{"_id":"StFr"},{"_id":"Bio"}],"month":"01","publisher":"Royal Society of Chemistry","day":"01","corr_author":"1","oa":1,"volume":248,"file":[{"date_created":"2024-07-16T07:46:39Z","checksum":"6515a227ed3e8942496fe6a1feeffd18","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access","file_id":"17249","file_size":1303733,"date_updated":"2024-07-16T07:46:39Z","content_type":"application/pdf","file_name":"2024_FaradayDiscussions_Mondal.pdf"}],"doi":"10.1039/d3fd00088e","researchdata_availability":"no","isi":1,"quality_controlled":"1","pmid":1,"year":"2024","publication_status":"published","intvolume":"       248","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (3.0)","name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode"},"ddc":["540"],"fulldoi":"https://doi.org/10.1039/d3fd00088e","das_tickbox":"0","date_published":"2024-01-01T00:00:00Z","file_date_updated":"2024-07-16T07:46:39Z","has_accepted_license":"1","keyword":["Physical and Theoretical Chemistry"],"article_processing_charge":"Yes (via OA deal)"},{"intvolume":"       248","publication_status":"published","quality_controlled":"1","year":"2024","pmid":1,"article_processing_charge":"No","keyword":["Physical and Theoretical Chemistry"],"date_published":"2024-01-29T00:00:00Z","das_tickbox":"0","fulldoi":"https://doi.org/10.1039/d3fd90062b","day":"29","publisher":"Royal Society of Chemistry","department":[{"_id":"StFr"}],"month":"01","external_id":{"isi":["001130090400001"],"pmid":["38112202"]},"isi":1,"doi":"10.1039/d3fd90062b","researchdata_availability":"no","volume":248,"date_created":"2023-12-20T10:48:09Z","status":"public","author":[{"first_name":"Lynden A.","last_name":"Archer","full_name":"Archer, Lynden A."},{"last_name":"Bruce","first_name":"Peter G.","full_name":"Bruce, Peter G."},{"full_name":"Calvo, Ernesto J.","first_name":"Ernesto J.","last_name":"Calvo"},{"full_name":"Dewar, Daniel","last_name":"Dewar","first_name":"Daniel"},{"last_name":"Ellison","first_name":"James H. J.","full_name":"Ellison, James H. J."},{"full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"last_name":"Gao","first_name":"Xiangwen","full_name":"Gao, Xiangwen"},{"first_name":"Laurence J.","last_name":"Hardwick","full_name":"Hardwick, Laurence J."},{"full_name":"Horwitz, Gabriela","last_name":"Horwitz","first_name":"Gabriela"},{"first_name":"Jürgen","last_name":"Janek","full_name":"Janek, Jürgen"},{"first_name":"Lee R.","last_name":"Johnson","full_name":"Johnson, Lee R."},{"full_name":"Jordan, Jack W.","last_name":"Jordan","first_name":"Jack W."},{"first_name":"Shoichi","last_name":"Matsuda","full_name":"Matsuda, Shoichi"},{"last_name":"Menkin","first_name":"Svetlana","full_name":"Menkin, Svetlana"},{"full_name":"Mondal, Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","last_name":"Mondal","first_name":"Soumyadip"},{"first_name":"Qianyuan","last_name":"Qiu","full_name":"Qiu, Qianyuan"},{"last_name":"Samarakoon","first_name":"Thukshan","full_name":"Samarakoon, Thukshan"},{"full_name":"Temprano, Israel","last_name":"Temprano","first_name":"Israel"},{"last_name":"Uosaki","first_name":"Kohei","full_name":"Uosaki, Kohei"},{"last_name":"Vailaya","first_name":"Ganesh","full_name":"Vailaya, Ganesh"},{"last_name":"Wachsman","first_name":"Eric D.","full_name":"Wachsman, Eric D."},{"last_name":"Wu","first_name":"Yiying","full_name":"Wu, Yiying"},{"full_name":"Ye, Shen","first_name":"Shen","last_name":"Ye"}],"title":"Towards practical metal–oxygen batteries: General discussion","_id":"14701","type":"journal_article","oa_version":"None","article_type":"letter_note","citation":{"apa":"Archer, L. A., Bruce, P. G., Calvo, E. J., Dewar, D., Ellison, J. H. J., Freunberger, S. A., … Ye, S. (2024). Towards practical metal–oxygen batteries: General discussion. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd90062b\">https://doi.org/10.1039/d3fd90062b</a>","chicago":"Archer, Lynden A., Peter G. Bruce, Ernesto J. Calvo, Daniel Dewar, James H. J. Ellison, Stefan Alexander Freunberger, Xiangwen Gao, et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d3fd90062b\">https://doi.org/10.1039/d3fd90062b</a>.","ista":"Archer LA, Bruce PG, Calvo EJ, Dewar D, Ellison JHJ, Freunberger SA, Gao X, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Menkin S, Mondal S, Qiu Q, Samarakoon T, Temprano I, Uosaki K, Vailaya G, Wachsman ED, Wu Y, Ye S. 2024. Towards practical metal–oxygen batteries: General discussion. Faraday Discussions. 248, 392–411.","ieee":"L. A. Archer <i>et al.</i>, “Towards practical metal–oxygen batteries: General discussion,” <i>Faraday Discussions</i>, vol. 248. Royal Society of Chemistry, pp. 392–411, 2024.","short":"L.A. Archer, P.G. Bruce, E.J. Calvo, D. Dewar, J.H.J. Ellison, S.A. Freunberger, X. Gao, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Menkin, S. Mondal, Q. Qiu, T. Samarakoon, I. Temprano, K. Uosaki, G. Vailaya, E.D. Wachsman, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 392–411.","ama":"Archer LA, Bruce PG, Calvo EJ, et al. Towards practical metal–oxygen batteries: General discussion. <i>Faraday Discussions</i>. 2024;248:392-411. doi:<a href=\"https://doi.org/10.1039/d3fd90062b\">10.1039/d3fd90062b</a>","mla":"Archer, Lynden A., et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” <i>Faraday Discussions</i>, vol. 248, Royal Society of Chemistry, 2024, pp. 392–411, doi:<a href=\"https://doi.org/10.1039/d3fd90062b\">10.1039/d3fd90062b</a>."},"page":"392-411","supplementarymaterial":"no","date_updated":"2026-10-21T09:52:47Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","publication":"Faraday Discussions","publication_identifier":{"issn":["1359-6640"],"eissn":["1364-5498"]},"language":[{"iso":"eng"}]},{"publication":"Faraday Discussions","scopus_import":"1","publication_identifier":{"issn":["1359-6640"],"eissn":["1364-5498"]},"language":[{"iso":"eng"}],"title":"Materials for stable metal–oxygen battery cathodes: general discussion","_id":"14702","status":"public","author":[{"full_name":"Attard, Gary A.","last_name":"Attard","first_name":"Gary A."},{"first_name":"Ernesto J.","last_name":"Calvo","full_name":"Calvo, Ernesto J."},{"last_name":"Curtiss","first_name":"Larry A.","full_name":"Curtiss, Larry A."},{"last_name":"Dewar","first_name":"Daniel","full_name":"Dewar, Daniel"},{"last_name":"Ellison","first_name":"James H. J.","full_name":"Ellison, James H. J."},{"full_name":"Gao, Xiangwen","last_name":"Gao","first_name":"Xiangwen"},{"last_name":"Grey","first_name":"Clare P.","full_name":"Grey, Clare P."},{"full_name":"Hardwick, Laurence J.","first_name":"Laurence J.","last_name":"Hardwick"},{"first_name":"Gabriela","last_name":"Horwitz","full_name":"Horwitz, Gabriela"},{"full_name":"Janek, Juergen","last_name":"Janek","first_name":"Juergen"},{"full_name":"Johnson, Lee R.","last_name":"Johnson","first_name":"Lee R."},{"full_name":"Jordan, Jack W.","first_name":"Jack W.","last_name":"Jordan"},{"last_name":"Matsuda","first_name":"Shoichi","full_name":"Matsuda, Shoichi"},{"last_name":"Mondal","first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","full_name":"Mondal, Soumyadip"},{"last_name":"Neale","first_name":"Alex R.","full_name":"Neale, Alex R."},{"last_name":"Ortiz-Vitoriano","first_name":"Nagore","full_name":"Ortiz-Vitoriano, Nagore"},{"first_name":"Israel","last_name":"Temprano","full_name":"Temprano, Israel"},{"last_name":"Vailaya","first_name":"Ganesh","full_name":"Vailaya, Ganesh"},{"full_name":"Wachsman, Eric D.","last_name":"Wachsman","first_name":"Eric D."},{"last_name":"Wang","first_name":"Hsien-Hau","full_name":"Wang, Hsien-Hau"},{"first_name":"Yiying","last_name":"Wu","full_name":"Wu, Yiying"},{"last_name":"Ye","first_name":"Shen","full_name":"Ye, Shen"}],"date_created":"2023-12-20T10:49:43Z","type":"journal_article","oa_version":"None","article_type":"letter_note","citation":{"ieee":"G. A. Attard <i>et al.</i>, “Materials for stable metal–oxygen battery cathodes: general discussion,” <i>Faraday Discussions</i>, vol. 248. Royal Society of Chemistry, pp. 75–88, 2024.","short":"G.A. Attard, E.J. Calvo, L.A. Curtiss, D. Dewar, J.H.J. Ellison, X. Gao, C.P. Grey, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Mondal, A.R. Neale, N. Ortiz-Vitoriano, I. Temprano, G. Vailaya, E.D. Wachsman, H.-H. Wang, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 75–88.","ista":"Attard GA, Calvo EJ, Curtiss LA, Dewar D, Ellison JHJ, Gao X, Grey CP, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Mondal S, Neale AR, Ortiz-Vitoriano N, Temprano I, Vailaya G, Wachsman ED, Wang H-H, Wu Y, Ye S. 2024. Materials for stable metal–oxygen battery cathodes: general discussion. Faraday Discussions. 248, 75–88.","mla":"Attard, Gary A., et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” <i>Faraday Discussions</i>, vol. 248, Royal Society of Chemistry, 2024, pp. 75–88, doi:<a href=\"https://doi.org/10.1039/d3fd90059b\">10.1039/d3fd90059b</a>.","ama":"Attard GA, Calvo EJ, Curtiss LA, et al. Materials for stable metal–oxygen battery cathodes: general discussion. <i>Faraday Discussions</i>. 2024;248:75-88. doi:<a href=\"https://doi.org/10.1039/d3fd90059b\">10.1039/d3fd90059b</a>","apa":"Attard, G. A., Calvo, E. J., Curtiss, L. A., Dewar, D., Ellison, J. H. J., Gao, X., … Ye, S. (2024). Materials for stable metal–oxygen battery cathodes: general discussion. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd90059b\">https://doi.org/10.1039/d3fd90059b</a>","chicago":"Attard, Gary A., Ernesto J. Calvo, Larry A. Curtiss, Daniel Dewar, James H. J. Ellison, Xiangwen Gao, Clare P. Grey, et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d3fd90059b\">https://doi.org/10.1039/d3fd90059b</a>."},"page":"75-88","date_updated":"2026-10-21T09:53:09Z","supplementarymaterial":"no","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","day":"29","external_id":{"pmid":["38109098"],"isi":["001130029600001"]},"publisher":"Royal Society of Chemistry","department":[{"_id":"StFr"}],"month":"01","isi":1,"volume":248,"doi":"10.1039/d3fd90059b","researchdata_availability":"no","publication_status":"published","quality_controlled":"1","year":"2024","pmid":1,"intvolume":"       248","date_published":"2024-01-29T00:00:00Z","article_processing_charge":"No","keyword":["Physical and Theoretical Chemistry"],"das_tickbox":"0","fulldoi":"https://doi.org/10.1039/d3fd90059b"},{"issue":"7","scopus_import":"1","publication":"Nature Catalysis","publication_identifier":{"issn":["2520-1158"]},"language":[{"iso":"eng"}],"status":"public","date_created":"2024-07-29T07:05:33Z","author":[{"full_name":"Mondal, Soumyadip","first_name":"Soumyadip","last_name":"Mondal","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48"},{"orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","last_name":"Freunberger"}],"_id":"17333","title":"Catalysing rate and capacity","abstract":[{"lang":"eng","text":"Aqueous zinc-ion batteries are attractive due to their low cost, environmental friendliness, and exceptional performance, but the latter remains poorly understood. Now, a fast catalytic step involved in oxygen redox catalysis is shown to contribute to capacity at a high rate."}],"article_type":"letter_note","oa_version":"None","type":"journal_article","page":"759-760","citation":{"apa":"Mondal, S., &#38; Freunberger, S. A. (2024). Catalysing rate and capacity. <i>Nature Catalysis</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41929-024-01184-7\">https://doi.org/10.1038/s41929-024-01184-7</a>","chicago":"Mondal, Soumyadip, and Stefan Alexander Freunberger. “Catalysing Rate and Capacity.” <i>Nature Catalysis</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41929-024-01184-7\">https://doi.org/10.1038/s41929-024-01184-7</a>.","ieee":"S. Mondal and S. A. Freunberger, “Catalysing rate and capacity,” <i>Nature Catalysis</i>, vol. 7, no. 7. Springer Nature, pp. 759–760, 2024.","short":"S. Mondal, S.A. Freunberger, Nature Catalysis 7 (2024) 759–760.","ista":"Mondal S, Freunberger SA. 2024. Catalysing rate and capacity. Nature Catalysis. 7(7), 759–760.","ama":"Mondal S, Freunberger SA. Catalysing rate and capacity. <i>Nature Catalysis</i>. 2024;7(7):759-760. doi:<a href=\"https://doi.org/10.1038/s41929-024-01184-7\">10.1038/s41929-024-01184-7</a>","mla":"Mondal, Soumyadip, and Stefan Alexander Freunberger. “Catalysing Rate and Capacity.” <i>Nature Catalysis</i>, vol. 7, no. 7, Springer Nature, 2024, pp. 759–60, doi:<a href=\"https://doi.org/10.1038/s41929-024-01184-7\">10.1038/s41929-024-01184-7</a>."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"no","date_updated":"2026-10-21T09:52:22Z","corr_author":"1","day":"26","department":[{"_id":"StFr"}],"month":"07","publisher":"Springer Nature","external_id":{"isi":["001278986700012"]},"isi":1,"doi":"10.1038/s41929-024-01184-7","researchdata_availability":"no","volume":7,"intvolume":"         7","quality_controlled":"1","year":"2024","publication_status":"published","article_processing_charge":"No","date_published":"2024-07-26T00:00:00Z","fulldoi":"https://doi.org/10.1038/s41929-024-01184-7","das_tickbox":"0"},{"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["000","570"],"intvolume":"        38","year":"2024","quality_controlled":"1","publication_status":"published","article_processing_charge":"No","file_date_updated":"2025-01-27T11:42:24Z","date_published":"2024-09-25T00:00:00Z","conference":{"name":"ICML: International Conference on Machine Learning","end_date":"2024-07-26","start_date":"2024-07-26"},"has_accepted_license":"1","arxiv":1,"das_tickbox":"0","corr_author":"1","oa":1,"day":"25","month":"09","department":[{"_id":"SyCr"},{"_id":"FrLo"},{"_id":"GradSch"}],"publisher":"Curran Associates","external_id":{"arxiv":["2405.17151"]},"file":[{"file_id":"18896","file_name":"2024_ICML_Cadei.pdf","content_type":"application/pdf","date_updated":"2025-01-27T11:42:24Z","file_size":4453014,"success":1,"checksum":"beedf05388bbdb7ddda81ec3d5ec7026","date_created":"2025-01-27T11:42:24Z","access_level":"open_access","creator":"dernst","relation":"main_file"}],"researchdata_availability":"yes","volume":38,"status":"public","author":[{"id":"0fa8b76f-72f0-11ef-b75a-a5da96e5ad6b","first_name":"Riccardo","last_name":"Cadei","full_name":"Cadei, Riccardo"},{"last_name":"Lindorfer","first_name":"Lukas","id":"85f0e6d3-06b3-11ec-8982-8c5049fa4455","full_name":"Lindorfer, Lukas"},{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schmid, Cordelia","last_name":"Schmid","first_name":"Cordelia"},{"full_name":"Locatello, Francesco","orcid":"0000-0002-4850-0683","id":"26cfd52f-2483-11ee-8040-88983bcc06d4","last_name":"Locatello","first_name":"Francesco"}],"date_created":"2025-01-14T07:27:26Z","_id":"18847","title":"Smoke and mirrors in causal downstream tasks","abstract":[{"lang":"eng","text":"Machine Learning and AI have the potential to transform data-driven\r\nscientific discovery, enabling accurate predictions for several scientific\r\nphenomena. As many scientific questions are inherently causal, this paper looks\r\nat the causal inference task of treatment effect estimation, where the outcome\r\nof interest is recorded in high-dimensional observations in a Randomized\r\nControlled Trial (RCT). Despite being the simplest possible causal setting and\r\na perfect fit for deep learning, we theoretically find that many common choices\r\nin the literature may lead to biased estimates. To test the practical impact of\r\nthese considerations, we recorded ISTAnt, the first real-world benchmark for\r\ncausal inference downstream tasks on high-dimensional observations as an RCT\r\nstudying how garden ants (Lasius neglectus) respond to microparticles applied\r\nonto their colony members by hygienic grooming. Comparing 6 480 models\r\nfine-tuned from state-of-the-art visual backbones, we find that the sampling\r\nand modeling choices significantly affect the accuracy of the causal estimate,\r\nand that classification accuracy is not a proxy thereof. We further validated\r\nthe analysis, repeating it on a synthetically generated visual data set\r\ncontrolling the causal model. Our results suggest that future benchmarks should\r\ncarefully consider real downstream scientific questions, especially causal\r\nones. Further, we highlight guidelines for representation learning methods to\r\nhelp answer causal questions in the sciences."}],"oa_version":"Published Version","type":"conference","citation":{"ama":"Cadei R, Lindorfer L, Cremer S, Schmid C, Locatello F. Smoke and mirrors in causal downstream tasks. In: <i>ICML 2024 Workshop AI4Science</i>. Vol 38. Curran Associates; 2024.","mla":"Cadei, Riccardo, et al. “Smoke and Mirrors in Causal Downstream Tasks.” <i>ICML 2024 Workshop AI4Science</i>, vol. 38, Curran Associates, 2024.","ista":"Cadei R, Lindorfer L, Cremer S, Schmid C, Locatello F. 2024. Smoke and mirrors in causal downstream tasks. ICML 2024 Workshop AI4Science. ICML: International Conference on Machine Learning vol. 38.","short":"R. Cadei, L. Lindorfer, S. Cremer, C. Schmid, F. Locatello, in:, ICML 2024 Workshop AI4Science, Curran Associates, 2024.","ieee":"R. Cadei, L. Lindorfer, S. Cremer, C. Schmid, and F. Locatello, “Smoke and mirrors in causal downstream tasks,” in <i>ICML 2024 Workshop AI4Science</i>, 2024, vol. 38.","chicago":"Cadei, Riccardo, Lukas Lindorfer, Sylvia Cremer, Cordelia Schmid, and Francesco Locatello. “Smoke and Mirrors in Causal Downstream Tasks.” In <i>ICML 2024 Workshop AI4Science</i>, Vol. 38. Curran Associates, 2024.","apa":"Cadei, R., Lindorfer, L., Cremer, S., Schmid, C., &#38; Locatello, F. (2024). Smoke and mirrors in causal downstream tasks. In <i>ICML 2024 Workshop AI4Science</i> (Vol. 38). Curran Associates."},"related_material":{"link":[{"relation":"software","url":"https://github.com/CausalLearningAI/ISTAnt"}],"record":[{"status":"public","id":"18895","relation":"research_data"},{"status":"public","relation":"later_version","id":"19509"}]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","supplementarymaterial":"yes","date_updated":"2026-10-21T10:52:44Z","scopus_import":"1","publication":"ICML 2024 Workshop AI4Science","acknowledgement":"We thank Piersilvio De Bartolomeis, and the full Causal Learning and Artificial Intelligence (CLAI) group at ISTA for the extremely helpful discussions. Riccardo Cadei was supported by a Google Research Scholar Award and a Google Initiated Gift to Francesco Locatello. We thank the Social Immunity team at ISTA particularly Michaela Hönigsberger and Wilfrid Jean Louis, for supporting the ecological experiment and Farnaz Beikzadeh Abbasi, Luisa Fiebig and Martin Estermann for annotating ant behavior in ISTAnt.","OA_place":"publisher","OA_type":"gold","language":[{"iso":"eng"}]}]