[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2022","date_created":"2022-02-25T07:52:11Z","ddc":["570"],"project":[{"name":"Molecular Mechanisms of Cerebral Cortex Development","_id":"25D61E48-B435-11E9-9278-68D0E5697425","grant_number":"618444","call_identifier":"FP7"},{"grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of radial neuronal migration"}],"date_published":"2022-07-07T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":1,"date_updated":"2026-04-07T13:29:13Z","publication_status":"published","external_id":{"pmid":["38596707"]},"department":[{"_id":"SiHi"},{"_id":"BjHo"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"ec_funded":1,"abstract":[{"lang":"eng","text":"The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lamination are associated with neurodevelopmental diseases. The developmental principle of cortical layer formation depends on concerted radial projection neuron migration, from their birthplace to their final target position. Radial migration occurs in defined sequential steps, regulated by a large array of signaling pathways. However, based on genetic loss-of-function experiments, most studies have thus far focused on the role of cell-autonomous gene function. Yet, cortical neuron migration in situ is a complex process and migrating neurons traverse along diverse cellular compartments and environments. The role of tissue-wide properties and genetic state in radial neuron migration is however not clear. Here we utilized mosaic analysis with double markers (MADM) technology to either sparsely or globally delete gene function, followed by quantitative single-cell phenotyping. The MADM-based gene ablation paradigms in combination with computational modeling demonstrated that global tissue-wide effects predominate cell-autonomous gene function albeit in a gene-specific manner. Our results thus suggest that the genetic landscape in a tissue critically affects the overall migration phenotype of individual cortical projection neurons. In a broader context, our findings imply that global tissue-wide effects represent an essential component of the underlying etiology associated with focal malformations of cortical development in particular, and neurological diseases in general."}],"doi":"10.1093/oons/kvac009","file_date_updated":"2023-08-16T08:00:30Z","file":[{"success":1,"content_type":"application/pdf","date_created":"2023-08-16T08:00:30Z","relation":"main_file","checksum":"822e76e056c07099d1fb27d1ece5941b","file_id":"14061","file_name":"2023_OxfordOpenNeuroscience_Hansen.pdf","date_updated":"2023-08-16T08:00:30Z","file_size":4846551,"access_level":"open_access","creator":"dernst"}],"intvolume":"         1","publication":"Oxford Open Neuroscience","type":"journal_article","day":"07","status":"public","quality_controlled":"1","month":"07","publisher":"Oxford University Press","publication_identifier":{"eissn":["2753-149X"]},"article_number":"kvac009","article_processing_charge":"No","article_type":"original","issue":"1","_id":"10791","corr_author":"1","oa":1,"language":[{"iso":"eng"}],"author":[{"first_name":"Andi H","last_name":"Hansen","full_name":"Hansen, Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","last_name":"Pauler","full_name":"Pauler, Florian","orcid":"0000-0002-7462-0048"},{"first_name":"Michael","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","last_name":"Riedl","full_name":"Riedl, Michael","orcid":"0000-0003-4844-6311"},{"last_name":"Streicher","full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen"},{"last_name":"Heger","full_name":"Heger, Anna-Magdalena","id":"4B76FFD2-F248-11E8-B48F-1D18A9856A87","first_name":"Anna-Magdalena"},{"id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","full_name":"Laukoter, Susanne","orcid":"0000-0002-7903-3010","last_name":"Laukoter","first_name":"Susanne"},{"first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","last_name":"Sommer","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M"},{"full_name":"Nicolas, Armel","last_name":"Nicolas","id":"2A103192-F248-11E8-B48F-1D18A9856A87","first_name":"Armel"},{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","first_name":"Björn"},{"full_name":"Tsai, Li Huei","last_name":"Tsai","first_name":"Li Huei"},{"full_name":"Rülicke, Thomas","last_name":"Rülicke","first_name":"Thomas"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","first_name":"Simon"}],"title":"Tissue-wide effects override cell-intrinsic gene function in radial neuron migration","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"12726"},{"id":"14530","status":"public","relation":"dissertation_contains"}]},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"PreCl"},{"_id":"Bio"}],"oa_version":"Published Version","acknowledgement":"A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences. This work also received support from IST Austria institutional funds; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007–2013) under REA grant agreement No 618444 to S.H.\r\nAPC funding was obtained by IST Austria institutional funds.\r\nWe thank A. Sommer and C. Czepe (VBCF GmbH, NGS Unit), L. Andersen, J. Sonntag and J. Renno for technical support and/or initial experiments; M. Sixt, J. Nimpf and all members of the Hippenmeyer lab for discussion. This research was supported by the Scientific Service Units of IST Austria through resources provided by the Imaging and Optics Facility, Lab Support Facility and Preclinical Facility.","pmid":1,"citation":{"ista":"Hansen AH, Pauler F, Riedl M, Streicher C, Heger A-M, Laukoter S, Sommer CM, Nicolas A, Hof B, Tsai LH, Rülicke T, Hippenmeyer S. 2022. Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. Oxford Open Neuroscience. 1(1), kvac009.","apa":"Hansen, A. H., Pauler, F., Riedl, M., Streicher, C., Heger, A.-M., Laukoter, S., … Hippenmeyer, S. (2022). Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. <i>Oxford Open Neuroscience</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/oons/kvac009\">https://doi.org/10.1093/oons/kvac009</a>","ieee":"A. H. Hansen <i>et al.</i>, “Tissue-wide effects override cell-intrinsic gene function in radial neuron migration,” <i>Oxford Open Neuroscience</i>, vol. 1, no. 1. Oxford University Press, 2022.","short":"A.H. Hansen, F. Pauler, M. Riedl, C. Streicher, A.-M. Heger, S. Laukoter, C.M. Sommer, A. Nicolas, B. Hof, L.H. Tsai, T. Rülicke, S. Hippenmeyer, Oxford Open Neuroscience 1 (2022).","ama":"Hansen AH, Pauler F, Riedl M, et al. Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. <i>Oxford Open Neuroscience</i>. 2022;1(1). doi:<a href=\"https://doi.org/10.1093/oons/kvac009\">10.1093/oons/kvac009</a>","chicago":"Hansen, Andi H, Florian Pauler, Michael Riedl, Carmen Streicher, Anna-Magdalena Heger, Susanne Laukoter, Christoph M Sommer, et al. “Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration.” <i>Oxford Open Neuroscience</i>. Oxford University Press, 2022. <a href=\"https://doi.org/10.1093/oons/kvac009\">https://doi.org/10.1093/oons/kvac009</a>.","mla":"Hansen, Andi H., et al. “Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration.” <i>Oxford Open Neuroscience</i>, vol. 1, no. 1, kvac009, Oxford University Press, 2022, doi:<a href=\"https://doi.org/10.1093/oons/kvac009\">10.1093/oons/kvac009</a>."},"has_accepted_license":"1"},{"date_updated":"2023-10-17T13:06:52Z","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"author":[{"full_name":"Schaaf, Zachary","last_name":"Schaaf","first_name":"Zachary"},{"last_name":"Tat","full_name":"Tat, Lyvin","first_name":"Lyvin"},{"last_name":"Cannizzaro","full_name":"Cannizzaro, Noemi","first_name":"Noemi"},{"full_name":"Green, Ralph","last_name":"Green","first_name":"Ralph"},{"last_name":"Rülicke","full_name":"Rülicke, Thomas","first_name":"Thomas"},{"first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer"},{"full_name":"Zarbalis, K","last_name":"Zarbalis","first_name":"K"}],"date_published":"2022-02-16T00:00:00Z","article_processing_charge":"No","_id":"10792","month":"02","year":"2022","date_created":"2022-02-25T07:53:26Z","publisher":"Research Square","main_file_link":[{"open_access":"1","url":"https://doi.org/10.21203/rs.3.rs-1316167/v1"}],"publication_identifier":{"eissn":["2693-5015"]},"day":"16","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"preprint","status":"public","page":"30","citation":{"mla":"Schaaf, Zachary, et al. <i>WDFY3 Cell Autonomously Controls Neuronal Migration</i>. Research Square, doi:<a href=\"https://doi.org/10.21203/rs.3.rs-1316167/v1\">10.21203/rs.3.rs-1316167/v1</a>.","chicago":"Schaaf, Zachary, Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke, Simon Hippenmeyer, and K Zarbalis. “WDFY3 Cell Autonomously Controls Neuronal Migration.” Research Square, n.d. <a href=\"https://doi.org/10.21203/rs.3.rs-1316167/v1\">https://doi.org/10.21203/rs.3.rs-1316167/v1</a>.","apa":"Schaaf, Z., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer, S., &#38; Zarbalis, K. (n.d.). WDFY3 cell autonomously controls neuronal migration. Research Square. <a href=\"https://doi.org/10.21203/rs.3.rs-1316167/v1\">https://doi.org/10.21203/rs.3.rs-1316167/v1</a>","ista":"Schaaf Z, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis K. WDFY3 cell autonomously controls neuronal migration. <a href=\"https://doi.org/10.21203/rs.3.rs-1316167/v1\">10.21203/rs.3.rs-1316167/v1</a>.","short":"Z. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer, K. Zarbalis, (n.d.).","ieee":"Z. Schaaf <i>et al.</i>, “WDFY3 cell autonomously controls neuronal migration.” Research Square.","ama":"Schaaf Z, Tat L, Cannizzaro N, et al. WDFY3 cell autonomously controls neuronal migration. doi:<a href=\"https://doi.org/10.21203/rs.3.rs-1316167/v1\">10.21203/rs.3.rs-1316167/v1</a>"},"pmid":1,"oa_version":"Preprint","abstract":[{"lang":"eng","text":"Background\r\nProper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate. Any disturbance in this process during prenatal stages may lead to neuronal migration disorders (NMDs), which can vary in extent from focal to global. Furthermore, NMDs show a substantial comorbidity with other neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous work demonstrated focal neuronal migration defects in mice carrying loss-of-function alleles of the recognized autism risk gene WDFY3. However, the cellular origins of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide critical insight into WDFY3-dependent disease pathology .\r\nMethods\r\nHere, in an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic analysis with double markers (MADM). MADM technology enabled us to genetically distinctly track and phenotypically analyze mutant and wild type cells concomitantly in vivo using immunofluorescent techniques.\r\nResults\r\nWe revealed a cell autonomous requirement of WDFY3 for accurate laminar positioning of cortical projection neurons and elimination of mispositioned cells during early postnatal life. In addition, we identified significant deviations in dendritic arborization, as well as synaptic density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant neurons in Wdfy3-MADM reporter mice at postnatal stages. Limitations While Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD pathology that remain inaccessible to investigation in humans, like most animal models, they do not a perfectly replicate all aspects of human ASD biology. The lack of human data makes it indeterminate whether morphological deviations described here apply to ASD patients.\r\nConclusions\r\nOur genetic approach revealed several cell autonomous requirements of Wdfy3 in neuronal development that could underly the pathogenic mechanisms of WDFY3-related ASD conditions. The results are also consistent with findings in other ASD animal models and patients and suggest an important role for Wdfy3 in regulating neuronal function and interconnectivity in postnatal life."}],"doi":"10.21203/rs.3.rs-1316167/v1","title":"WDFY3 cell autonomously controls neuronal migration","publication_status":"submitted","department":[{"_id":"SiHi"}],"external_id":{"pmid":["PPR454733"]}},{"volume":58,"date_updated":"2025-04-14T07:43:48Z","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"date_published":"2022-02-01T00:00:00Z","year":"2022","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2007.08272"}],"date_created":"2022-02-27T23:01:50Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        58","publication":"Annales de l'institut Henri Poincare (B) Probability and Statistics","abstract":[{"lang":"eng","text":"We consider symmetric partial exclusion and inclusion processes in a general graph in contact with reservoirs, where we allow both for edge disorder and well-chosen site disorder. We extend the classical dualities to this context and then we derive new orthogonal polynomial dualities. From the classical dualities, we derive the uniqueness of the non-equilibrium steady state and obtain correlation inequalities. Starting from the orthogonal polynomial dualities, we show universal properties of n-point correlation functions in the non-equilibrium steady state for systems with at most two different reservoir parameters, such as a chain with reservoirs at left and right ends."},{"lang":"fre","text":"Nous considérons des processus d’exclusion partielle, et des processus d’inclusion sur un graphe général en contact avec des réservoirs. Nous autorisons la présence de inhomogenéités sur les arrêts ainsi que sur les sommets du graph. Nous généralisons les “dualités classiques” dans ce contexte et nous démontrons des nouvelles dualités orthogonales. À partir des dualités classiques, nous démontrons l’unicité de l’état stationnaire non-équilibre, ainsi que des inégalités de corrélation. À partir des dualités orthogonales nous démontrons des propriétés universelles des fonctions de corrélation à n points dans l’état stationnaire non-équilibre pour des systèmes avec deux paramètres de réservoirs inégaux, comme par exemple une chaîne avec des réservoirs à droite et à gauche."}],"ec_funded":1,"doi":"10.1214/21-AIHP1163","publication_status":"published","external_id":{"arxiv":["2007.08272"],"isi":["000752489300010"]},"department":[{"_id":"JaMa"}],"language":[{"iso":"eng"}],"oa":1,"author":[{"first_name":"Simone","full_name":"Floreani, Simone","last_name":"Floreani"},{"first_name":"Frank","full_name":"Redig, Frank","last_name":"Redig"},{"first_name":"Federico","last_name":"Sau","full_name":"Sau, Federico","id":"E1836206-9F16-11E9-8814-AEFDE5697425"}],"article_processing_charge":"No","article_type":"original","_id":"10797","issue":"1","quality_controlled":"1","month":"02","publisher":"Institute of Mathematical Statistics","publication_identifier":{"issn":["0246-0203"]},"type":"journal_article","day":"01","status":"public","page":"220-247","citation":{"ieee":"S. Floreani, F. Redig, and F. Sau, “Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium correlations,” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 58, no. 1. Institute of Mathematical Statistics, pp. 220–247, 2022.","ama":"Floreani S, Redig F, Sau F. Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium correlations. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. 2022;58(1):220-247. doi:<a href=\"https://doi.org/10.1214/21-AIHP1163\">10.1214/21-AIHP1163</a>","short":"S. Floreani, F. Redig, F. Sau, Annales de l’institut Henri Poincare (B) Probability and Statistics 58 (2022) 220–247.","apa":"Floreani, S., Redig, F., &#38; Sau, F. (2022). Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium correlations. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/21-AIHP1163\">https://doi.org/10.1214/21-AIHP1163</a>","ista":"Floreani S, Redig F, Sau F. 2022. Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium correlations. Annales de l’institut Henri Poincare (B) Probability and Statistics. 58(1), 220–247.","chicago":"Floreani, Simone, Frank Redig, and Federico Sau. “Orthogonal Polynomial Duality of Boundary Driven Particle Systems and Non-Equilibrium Correlations.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics, 2022. <a href=\"https://doi.org/10.1214/21-AIHP1163\">https://doi.org/10.1214/21-AIHP1163</a>.","mla":"Floreani, Simone, et al. “Orthogonal Polynomial Duality of Boundary Driven Particle Systems and Non-Equilibrium Correlations.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 58, no. 1, Institute of Mathematical Statistics, 2022, pp. 220–47, doi:<a href=\"https://doi.org/10.1214/21-AIHP1163\">10.1214/21-AIHP1163</a>."},"arxiv":1,"scopus_import":"1","oa_version":"Preprint","acknowledgement":"The authors would like to thank Gioia Carinci and Cristian Giardinà for useful discussions. F.R. and S.F. thank Jean-René Chazottes for a stay at CPHT (Institut Polytechnique de Paris), in the realm of Chaire d’Alembert (Paris-Saclay University), where part of this work was performed. S.F. acknowledges Simona Villa for her support in creating the picture. S.F. acknowledges financial support from NWO via the grant TOP1.17.019. F.S. acknowledges financial support from the European Union’s Horizon 2020 research and innovation programme under the Marie-Skłodowska-Curie grant agreement No. 754411.","isi":1,"title":"Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium correlations"},{"has_accepted_license":"1","citation":{"apa":"Konstantinov, N. H. (2022). <i>Robustness and fairness in machine learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>","ista":"Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute of Science and Technology Austria.","short":"N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute of Science and Technology Austria, 2022.","ieee":"N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute of Science and Technology Austria, 2022.","ama":"Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>","mla":"Konstantinov, Nikola H. <i>Robustness and Fairness in Machine Learning</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>.","chicago":"Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>."},"oa_version":"Published Version","related_material":{"record":[{"id":"10802","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"10803"},{"status":"public","relation":"part_of_dissertation","id":"6590"},{"status":"public","relation":"part_of_dissertation","id":"8724"}]},"title":"Robustness and fairness in machine learning","supervisor":[{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","full_name":"Lampert, Christoph","orcid":"0000-0001-8622-7887","last_name":"Lampert","first_name":"Christoph"}],"author":[{"id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87","full_name":"Konstantinov, Nikola H","orcid":"0009-0009-5204-7621","last_name":"Konstantinov","first_name":"Nikola H"}],"language":[{"iso":"eng"}],"oa":1,"corr_author":"1","_id":"10799","keyword":["robustness","fairness","machine learning","PAC learning","adversarial learning"],"article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-015-2"]},"month":"03","OA_place":"publisher","status":"public","page":"176","day":"08","type":"dissertation","file":[{"checksum":"626bc523ae8822d20e635d0e2d95182e","file_id":"10823","relation":"main_file","date_created":"2022-03-06T11:42:54Z","content_type":"application/pdf","success":1,"creator":"nkonstan","access_level":"open_access","date_updated":"2022-03-06T11:42:54Z","file_size":4204905,"file_name":"thesis.pdf"},{"content_type":"application/x-zip-compressed","date_created":"2022-03-06T11:42:57Z","relation":"source_file","file_id":"10824","checksum":"e2ca2b88350ac8ea1515b948885cbcb1","date_updated":"2022-03-10T12:11:48Z","file_size":22841103,"file_name":"thesis.zip","access_level":"closed","creator":"nkonstan"}],"file_date_updated":"2022-03-10T12:11:48Z","degree_awarded":"PhD","doi":"10.15479/at:ista:10799","alternative_title":["ISTA Thesis"],"abstract":[{"lang":"eng","text":"Because of the increasing popularity of machine learning methods, it is becoming important to understand the impact of learned components on automated decision-making systems and to guarantee that their consequences are beneficial to society. In other words, it is necessary to ensure that machine learning is sufficiently trustworthy to be used in real-world applications. This thesis studies two properties of machine learning models that are highly desirable for the\r\nsake of reliability: robustness and fairness. In the first part of the thesis we study the robustness of learning algorithms to training data corruption. Previous work has shown that machine learning models are vulnerable to a range\r\nof training set issues, varying from label noise through systematic biases to worst-case data manipulations. This is an especially relevant problem from a present perspective, since modern machine learning methods are particularly data hungry and therefore practitioners often have to rely on data collected from various external sources, e.g. from the Internet, from app users or via crowdsourcing. Naturally, such sources vary greatly in the quality and reliability of the\r\ndata they provide. With these considerations in mind, we study the problem of designing machine learning algorithms that are robust to corruptions in data coming from multiple sources. We show that, in contrast to the case of a single dataset with outliers, successful learning within this model is possible both theoretically and practically, even under worst-case data corruptions. The second part of this thesis deals with fairness-aware machine learning. There are multiple areas where machine learning models have shown promising results, but where careful considerations are required, in order to avoid discrimanative decisions taken by such learned components. Ensuring fairness can be particularly challenging, because real-world training datasets are expected to contain various forms of historical bias that may affect the learning process. In this thesis we show that data corruption can indeed render the problem of achieving fairness impossible, by tightly characterizing the theoretical limits of fair learning under worst-case data manipulations. However, assuming access to clean data, we also show how fairness-aware learning can be made practical in contexts beyond binary classification, in particular in the challenging learning to rank setting."}],"ec_funded":1,"department":[{"_id":"GradSch"},{"_id":"ChLa"}],"publication_status":"published","date_updated":"2026-04-07T14:19:48Z","date_published":"2022-03-08T00:00:00Z","project":[{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"}],"ddc":["000"],"date_created":"2022-02-28T13:03:49Z","year":"2022","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"year":"2022","date_created":"2022-02-28T14:05:42Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-04-07T14:19:48Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":23,"date_published":"2022-05-01T00:00:00Z","ddc":["004"],"abstract":[{"lang":"eng","text":"Addressing fairness concerns about machine learning models is a crucial step towards their long-term adoption in real-world automated systems. While many approaches have been developed for training fair models from data, little is known about the robustness of these methods to data corruption. In this work we consider fairness-aware learning under worst-case data manipulations. We show that an adversary can in some situations force any learner to return an overly biased classifier, regardless of the sample size and with or without degrading\r\naccuracy, and that the strength of the excess bias increases for learning problems with underrepresented protected groups in the data. We also prove that our hardness results are tight up to constant factors. To this end, we study two natural learning algorithms that optimize for both accuracy and fairness and show that these algorithms enjoy guarantees that are order-optimal in terms of the corruption ratio and the protected groups frequencies in the large data\r\nlimit."}],"publication_status":"published","department":[{"_id":"ChLa"}],"external_id":{"arxiv":["2102.06004"]},"intvolume":"        23","file":[{"date_created":"2022-07-12T15:08:28Z","success":1,"content_type":"application/pdf","checksum":"9cac897b54a0ddf3a553a2c33e88cfda","file_id":"11570","relation":"main_file","access_level":"open_access","file_name":"2022_JournalMachineLearningResearch_Konstantinov.pdf","file_size":551862,"date_updated":"2022-07-12T15:08:28Z","creator":"kschuh"}],"publication":"Journal of Machine Learning Research","file_date_updated":"2022-07-12T15:08:28Z","month":"05","quality_controlled":"1","publication_identifier":{"eissn":["1533-7928"],"issn":["1532-4435"]},"publisher":"ML Research Press","day":"01","type":"journal_article","status":"public","page":"1-60","oa":1,"language":[{"iso":"eng"}],"author":[{"id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87","orcid":"0009-0009-5204-7621","full_name":"Konstantinov, Nikola H","last_name":"Konstantinov","first_name":"Nikola H"},{"first_name":"Christoph","last_name":"Lampert","full_name":"Lampert, Christoph","orcid":"0000-0002-4561-241X","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"No","article_type":"original","_id":"10802","keyword":["Fairness","robustness","data poisoning","trustworthy machine learning","PAC learning"],"corr_author":"1","acknowledgement":"The authors thank Eugenia Iofinova and Bernd Prach for providing feedback on early versions of this paper. This publication was made possible by an ETH AI Center postdoctoral fellowship to Nikola Konstantinov.","oa_version":"Published Version","scopus_import":"1","related_material":{"record":[{"id":"13241","relation":"shorter_version","status":"public"},{"relation":"dissertation_contains","status":"public","id":"10799"}]},"title":"Fairness-aware PAC learning from corrupted data","arxiv":1,"citation":{"ama":"Konstantinov NH, Lampert C. Fairness-aware PAC learning from corrupted data. <i>Journal of Machine Learning Research</i>. 2022;23:1-60.","ieee":"N. H. Konstantinov and C. Lampert, “Fairness-aware PAC learning from corrupted data,” <i>Journal of Machine Learning Research</i>, vol. 23. ML Research Press, pp. 1–60, 2022.","short":"N.H. Konstantinov, C. Lampert, Journal of Machine Learning Research 23 (2022) 1–60.","apa":"Konstantinov, N. H., &#38; Lampert, C. (2022). Fairness-aware PAC learning from corrupted data. <i>Journal of Machine Learning Research</i>. ML Research Press.","ista":"Konstantinov NH, Lampert C. 2022. Fairness-aware PAC learning from corrupted data. Journal of Machine Learning Research. 23, 1–60.","chicago":"Konstantinov, Nikola H, and Christoph Lampert. “Fairness-Aware PAC Learning from Corrupted Data.” <i>Journal of Machine Learning Research</i>. ML Research Press, 2022.","mla":"Konstantinov, Nikola H., and Christoph Lampert. “Fairness-Aware PAC Learning from Corrupted Data.” <i>Journal of Machine Learning Research</i>, vol. 23, ML Research Press, 2022, pp. 1–60."},"has_accepted_license":"1"},{"volume":20,"date_updated":"2023-08-02T14:41:44Z","date_published":"2022-08-01T00:00:00Z","date_created":"2022-03-04T04:33:49Z","year":"2022","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Nature Reviews Microbiology","intvolume":"        20","doi":"10.1038/s41579-022-00700-5","abstract":[{"text":"Several promising strategies based on combining or cycling different antibiotics have been proposed to increase efficacy and counteract resistance evolution, but we still lack a deep understanding of the physiological responses and genetic mechanisms that underlie antibiotic interactions and the clinical applicability of these strategies. In antibiotic-exposed bacteria, the combined effects of physiological stress responses and emerging resistance mutations (occurring at different time scales) generate complex and often unpredictable dynamics. In this Review, we present our current understanding of bacterial cell physiology and genetics of responses to antibiotics. We emphasize recently discovered mechanisms of synergistic and antagonistic drug interactions, hysteresis in temporal interactions between antibiotics that arise from microbial physiology and interactions between antibiotics and resistance mutations that can cause collateral sensitivity or cross-resistance. We discuss possible connections between the different phenomena and indicate relevant research directions. A better and more unified understanding of drug and genetic interactions is likely to advance antibiotic therapy.","lang":"eng"}],"external_id":{"isi":["000763891900001"],"pmid":["35241807"]},"department":[{"_id":"CaGu"}],"publication_status":"published","author":[{"first_name":"Roderich","full_name":"Römhild, Roderich","orcid":"0000-0001-9480-5261","last_name":"Römhild","id":"68E56E44-62B0-11EA-B963-444F3DDC885E"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X","first_name":"Mark Tobias"},{"first_name":"Dan I.","last_name":"Andersson","full_name":"Andersson, Dan I."}],"language":[{"iso":"eng"}],"keyword":["General Immunology and Microbiology","Microbiology","Infectious Diseases"],"_id":"10812","article_type":"review","article_processing_charge":"No","publication_identifier":{"eissn":["1740-1534"],"issn":["1740-1526"]},"publisher":"Springer Nature","month":"08","quality_controlled":"1","page":"478-490","status":"public","type":"journal_article","day":"01","citation":{"mla":"Römhild, Roderich, et al. “The Physiology and Genetics of Bacterial Responses to Antibiotic Combinations.” <i>Nature Reviews Microbiology</i>, vol. 20, Springer Nature, 2022, pp. 478–90, doi:<a href=\"https://doi.org/10.1038/s41579-022-00700-5\">10.1038/s41579-022-00700-5</a>.","chicago":"Römhild, Roderich, Mark Tobias Bollenbach, and Dan I. Andersson. “The Physiology and Genetics of Bacterial Responses to Antibiotic Combinations.” <i>Nature Reviews Microbiology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41579-022-00700-5\">https://doi.org/10.1038/s41579-022-00700-5</a>.","apa":"Römhild, R., Bollenbach, M. T., &#38; Andersson, D. I. (2022). The physiology and genetics of bacterial responses to antibiotic combinations. <i>Nature Reviews Microbiology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41579-022-00700-5\">https://doi.org/10.1038/s41579-022-00700-5</a>","ista":"Römhild R, Bollenbach MT, Andersson DI. 2022. The physiology and genetics of bacterial responses to antibiotic combinations. Nature Reviews Microbiology. 20, 478–490.","ieee":"R. Römhild, M. T. Bollenbach, and D. I. Andersson, “The physiology and genetics of bacterial responses to antibiotic combinations,” <i>Nature Reviews Microbiology</i>, vol. 20. Springer Nature, pp. 478–490, 2022.","short":"R. Römhild, M.T. Bollenbach, D.I. Andersson, Nature Reviews Microbiology 20 (2022) 478–490.","ama":"Römhild R, Bollenbach MT, Andersson DI. The physiology and genetics of bacterial responses to antibiotic combinations. <i>Nature Reviews Microbiology</i>. 2022;20:478-490. doi:<a href=\"https://doi.org/10.1038/s41579-022-00700-5\">10.1038/s41579-022-00700-5</a>"},"pmid":1,"isi":1,"acknowledgement":"The authors thank B. Kavčič and H. Schulenburg for constructive feedback on the manuscript.","oa_version":"None","scopus_import":"1","title":"The physiology and genetics of bacterial responses to antibiotic combinations"},{"intvolume":"         5","publication":"Nature Catalysis","publication_status":"published","department":[{"_id":"StFr"}],"external_id":{"isi":["000763879400001"]},"abstract":[{"text":"Redox mediators could catalyse otherwise slow and energy-inefficient cycling of Li–S and Li–O2 batteries by shuttling electrons or holes between the electrode and the solid insulating storage materials. For mediators to work efficiently they need to oxidize the solid with fast kinetics but with the lowest possible overpotential. However, the dependence of kinetics and overpotential is unclear, which hinders informed improvement. Here, we find that when the redox potentials of mediators are tuned via, for example, Li+ concentration in the electrolyte, they exhibit distinct threshold potentials, where the kinetics accelerate several-fold within a range as small as 10 mV. This phenomenon is independent of types of mediator and electrolyte. The acceleration originates from the overpotentials required to activate fast Li+/e− extraction and the following chemical step at specific abundant surface facets. Efficient redox catalysis at insulating solids therefore requires careful consideration of the surface conditions of the storage materials and electrolyte-dependent redox potentials, which may be tuned by salt concentrations or solvents.","lang":"eng"}],"doi":"10.1038/s41929-022-00752-z","date_published":"2022-03-03T00:00:00Z","date_updated":"2024-10-09T21:01:46Z","volume":5,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","year":"2022","date_created":"2022-03-04T07:50:10Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.21203/rs.3.rs-750965/v1"}],"citation":{"mla":"Cao, Deqing, et al. “Threshold Potentials for Fast Kinetics during Mediated Redox Catalysis of Insulators in Li–O2 and Li–S Batteries.” <i>Nature Catalysis</i>, vol. 5, Springer Nature, 2022, pp. 193–201, doi:<a href=\"https://doi.org/10.1038/s41929-022-00752-z\">10.1038/s41929-022-00752-z</a>.","chicago":"Cao, Deqing, Xiaoxiao Shen, Aiping Wang, Fengjiao Yu, Yuping Wu, Siqi Shi, Stefan Alexander Freunberger, and Yuhui Chen. “Threshold Potentials for Fast Kinetics during Mediated Redox Catalysis of Insulators in Li–O2 and Li–S Batteries.” <i>Nature Catalysis</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41929-022-00752-z\">https://doi.org/10.1038/s41929-022-00752-z</a>.","ieee":"D. Cao <i>et al.</i>, “Threshold potentials for fast kinetics during mediated redox catalysis of insulators in Li–O2 and Li–S batteries,” <i>Nature Catalysis</i>, vol. 5. Springer Nature, pp. 193–201, 2022.","ama":"Cao D, Shen X, Wang A, et al. Threshold potentials for fast kinetics during mediated redox catalysis of insulators in Li–O2 and Li–S batteries. <i>Nature Catalysis</i>. 2022;5:193-201. doi:<a href=\"https://doi.org/10.1038/s41929-022-00752-z\">10.1038/s41929-022-00752-z</a>","short":"D. Cao, X. Shen, A. Wang, F. Yu, Y. Wu, S. Shi, S.A. Freunberger, Y. Chen, Nature Catalysis 5 (2022) 193–201.","apa":"Cao, D., Shen, X., Wang, A., Yu, F., Wu, Y., Shi, S., … Chen, Y. (2022). Threshold potentials for fast kinetics during mediated redox catalysis of insulators in Li–O2 and Li–S batteries. <i>Nature Catalysis</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41929-022-00752-z\">https://doi.org/10.1038/s41929-022-00752-z</a>","ista":"Cao D, Shen X, Wang A, Yu F, Wu Y, Shi S, Freunberger SA, Chen Y. 2022. Threshold potentials for fast kinetics during mediated redox catalysis of insulators in Li–O2 and Li–S batteries. Nature Catalysis. 5, 193–201."},"title":"Threshold potentials for fast kinetics during mediated redox catalysis of insulators in Li–O2 and Li–S batteries","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"9978"}]},"oa_version":"Preprint","scopus_import":"1","acknowledgement":"This work was financially supported by the National Natural Science Foundation of China (grant nos. 51773092, 21975124, 11874254, 51802187 and U2030206). It was further supported by Fujian science & technology innovation laboratory for energy devices of China (21C-LAB), Key Research Project of Zhejiang Laboratory (grant no. 2021PE0AC02) and the Cultivation Program for the Excellent Doctoral Dissertation of Nanjing Tech University. S.A.F. is indebted to IST Austria for support.","isi":1,"article_type":"original","article_processing_charge":"No","_id":"10813","keyword":["Process Chemistry and Technology","Biochemistry","Bioengineering","Catalysis"],"corr_author":"1","oa":1,"language":[{"iso":"eng"}],"author":[{"full_name":"Cao, Deqing","last_name":"Cao","first_name":"Deqing"},{"full_name":"Shen, Xiaoxiao","last_name":"Shen","first_name":"Xiaoxiao"},{"last_name":"Wang","full_name":"Wang, Aiping","first_name":"Aiping"},{"full_name":"Yu, Fengjiao","last_name":"Yu","first_name":"Fengjiao"},{"full_name":"Wu, Yuping","last_name":"Wu","first_name":"Yuping"},{"full_name":"Shi, Siqi","last_name":"Shi","first_name":"Siqi"},{"first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"full_name":"Chen, Yuhui","last_name":"Chen","first_name":"Yuhui"}],"day":"03","type":"journal_article","page":"193-201","status":"public","month":"03","quality_controlled":"1","publication_identifier":{"issn":["2520-1158"]},"publisher":"Springer Nature"},{"title":"When different norms lead to same billiard trajectories?","acknowledgement":"AA was supported by European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 78818 Alpha). RK was supported by the Federal professorship program Grant 1.456.2016/1.4 and the Russian Foundation for Basic Research Grants 18-01-00036 and 19-01-00169. Open access funding provided by Institute of Science and Technology (IST Austria). The authors thank Alexey Balitskiy, Milena Radnović, and Serge Tabachnikov for useful discussions.","oa_version":"Published Version","scopus_import":"1","has_accepted_license":"1","arxiv":1,"citation":{"apa":"Akopyan, A., &#38; Karasev, R. (2022). When different norms lead to same billiard trajectories? <i>European Journal of Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40879-020-00405-0\">https://doi.org/10.1007/s40879-020-00405-0</a>","ista":"Akopyan A, Karasev R. 2022. When different norms lead to same billiard trajectories? European Journal of Mathematics. 8(4), 1309–1312.","ama":"Akopyan A, Karasev R. When different norms lead to same billiard trajectories? <i>European Journal of Mathematics</i>. 2022;8(4):1309-1312. doi:<a href=\"https://doi.org/10.1007/s40879-020-00405-0\">10.1007/s40879-020-00405-0</a>","ieee":"A. Akopyan and R. Karasev, “When different norms lead to same billiard trajectories?,” <i>European Journal of Mathematics</i>, vol. 8, no. 4. Springer Nature, pp. 1309–1312, 2022.","short":"A. Akopyan, R. Karasev, European Journal of Mathematics 8 (2022) 1309–1312.","mla":"Akopyan, Arseniy, and Roman Karasev. “When Different Norms Lead to Same Billiard Trajectories?” <i>European Journal of Mathematics</i>, vol. 8, no. 4, Springer Nature, 2022, pp. 1309–12, doi:<a href=\"https://doi.org/10.1007/s40879-020-00405-0\">10.1007/s40879-020-00405-0</a>.","chicago":"Akopyan, Arseniy, and Roman Karasev. “When Different Norms Lead to Same Billiard Trajectories?” <i>European Journal of Mathematics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s40879-020-00405-0\">https://doi.org/10.1007/s40879-020-00405-0</a>."},"status":"public","page":"1309 - 1312","day":"01","type":"journal_article","publisher":"Springer Nature","publication_identifier":{"eissn":["2199-6768"],"issn":["2199-675X"]},"quality_controlled":"1","month":"12","issue":"4","_id":"7791","corr_author":"1","article_processing_charge":"Yes (via OA deal)","article_type":"original","author":[{"id":"430D2C90-F248-11E8-B48F-1D18A9856A87","last_name":"Akopyan","full_name":"Akopyan, Arseniy","orcid":"0000-0002-2548-617X","first_name":"Arseniy"},{"full_name":"Karasev, Roman","last_name":"Karasev","first_name":"Roman"}],"oa":1,"language":[{"iso":"eng"}],"department":[{"_id":"HeEd"}],"external_id":{"arxiv":["1912.12685"]},"publication_status":"published","doi":"10.1007/s40879-020-00405-0","ec_funded":1,"abstract":[{"lang":"eng","text":"Extending a result of Milena Radnovic and Serge Tabachnikov, we establish conditionsfor two different non-symmetric norms to define the same billiard reflection law."}],"file_date_updated":"2020-07-14T12:48:03Z","publication":"European Journal of Mathematics","file":[{"content_type":"application/pdf","date_created":"2020-05-04T10:33:42Z","relation":"main_file","file_id":"7796","checksum":"f53e71fd03744075adcd0b8fc1b8423d","date_updated":"2020-07-14T12:48:03Z","file_name":"2020_EuropMathematics_Akopyan.pdf","file_size":263926,"access_level":"open_access","creator":"dernst"}],"intvolume":"         8","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_created":"2020-05-03T22:00:48Z","year":"2022","date_published":"2022-12-01T00:00:00Z","ddc":["510"],"project":[{"call_identifier":"H2020","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","grant_number":"788183","name":"Alpha Shape Theory Extended"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"date_updated":"2025-04-14T07:48:36Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":8},{"file_date_updated":"2021-12-27T10:36:40Z","file":[{"access_level":"open_access","date_updated":"2021-12-27T10:36:40Z","file_name":"2021_Algorithmica_Alistarh.pdf","file_size":525950,"creator":"cchlebak","date_created":"2021-12-27T10:36:40Z","content_type":"application/pdf","success":1,"checksum":"21169b25b0c8e17b21e12af22bff9870","file_id":"10577","relation":"main_file"}],"publication":"Algorithmica","intvolume":"        84","department":[{"_id":"DaAl"}],"external_id":{"isi":["000734004600001"],"arxiv":["2003.09297"]},"publication_status":"published","doi":"10.1007/s00453-021-00905-9","abstract":[{"lang":"eng","text":"We consider the following dynamic load-balancing process: given an underlying graph G with n nodes, in each step t≥ 0, one unit of load is created, and placed at a randomly chosen graph node. In the same step, the chosen node picks a random neighbor, and the two nodes balance their loads by averaging them. We are interested in the expected gap between the minimum and maximum loads at nodes as the process progresses, and its dependence on n and on the graph structure. Variants of the above graphical balanced allocation process have been studied previously by Peres, Talwar, and Wieder [Peres et al., 2015], and by Sauerwald and Sun [Sauerwald and Sun, 2015]. These authors left as open the question of characterizing the gap in the case of cycle graphs in the dynamic case, where weights are created during the algorithm’s execution. For this case, the only known upper bound is of 𝒪(n log n), following from a majorization argument due to [Peres et al., 2015], which analyzes a related graphical allocation process. In this paper, we provide an upper bound of 𝒪 (√n log n) on the expected gap of the above process for cycles of length n. We introduce a new potential analysis technique, which enables us to bound the difference in load between k-hop neighbors on the cycle, for any k ≤ n/2. We complement this with a \"gap covering\" argument, which bounds the maximum value of the gap by bounding its value across all possible subsets of a certain structure, and recursively bounding the gaps within each subset. We provide analytical and experimental evidence that our upper bound on the gap is tight up to a logarithmic factor. "}],"ec_funded":1,"date_published":"2022-04-01T00:00:00Z","project":[{"name":"Elastic Coordination for Scalable Machine Learning","call_identifier":"H2020","grant_number":"805223","_id":"268A44D6-B435-11E9-9278-68D0E5697425"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"ddc":["000"],"conference":{"location":"Virtual, Online; Germany","start_date":"2020-07-08","name":"ICALP: Automata, Languages and Programming","end_date":"2020-07-11"},"date_updated":"2025-07-10T11:55:11Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":84,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2020-08-24T06:24:04Z","year":"2022","has_accepted_license":"1","arxiv":1,"citation":{"mla":"Alistarh, Dan-Adrian, et al. “Dynamic Averaging Load Balancing on Cycles.” <i>Algorithmica</i>, vol. 84, no. 4, Springer Nature, 2022, pp. 1007–29, doi:<a href=\"https://doi.org/10.1007/s00453-021-00905-9\">10.1007/s00453-021-00905-9</a>.","chicago":"Alistarh, Dan-Adrian, Giorgi Nadiradze, and Amirmojtaba Sabour. “Dynamic Averaging Load Balancing on Cycles.” <i>Algorithmica</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00453-021-00905-9\">https://doi.org/10.1007/s00453-021-00905-9</a>.","short":"D.-A. Alistarh, G. Nadiradze, A. Sabour, Algorithmica 84 (2022) 1007–1029.","ama":"Alistarh D-A, Nadiradze G, Sabour A. Dynamic averaging load balancing on cycles. <i>Algorithmica</i>. 2022;84(4):1007-1029. doi:<a href=\"https://doi.org/10.1007/s00453-021-00905-9\">10.1007/s00453-021-00905-9</a>","ieee":"D.-A. Alistarh, G. Nadiradze, and A. Sabour, “Dynamic averaging load balancing on cycles,” <i>Algorithmica</i>, vol. 84, no. 4. Springer Nature, pp. 1007–1029, 2022.","apa":"Alistarh, D.-A., Nadiradze, G., &#38; Sabour, A. (2022). Dynamic averaging load balancing on cycles. <i>Algorithmica</i>. Virtual, Online; Germany: Springer Nature. <a href=\"https://doi.org/10.1007/s00453-021-00905-9\">https://doi.org/10.1007/s00453-021-00905-9</a>","ista":"Alistarh D-A, Nadiradze G, Sabour A. 2022. Dynamic averaging load balancing on cycles. Algorithmica. 84(4), 1007–1029."},"title":"Dynamic averaging load balancing on cycles","related_material":{"record":[{"id":"15077","status":"public","relation":"earlier_version"}],"link":[{"url":"https://doi.org/10.4230/LIPIcs.ICALP.2020.7","relation":"earlier_version"}]},"isi":1,"oa_version":"Published Version","scopus_import":"1","acknowledgement":"The authors sincerely thank Thomas Sauerwald and George Giakkoupis for insightful discussions, and Mohsen Ghaffari, Yuval Peres, and Udi Wieder for feedback on earlier versions of this draft. We also thank the ICALP anonymous reviewers for their very useful comments. Open access funding provided by Institute of Science and Technology (IST Austria). Funding was provided by European Research Council (Grant No. PR1042ERC01).","issue":"4","_id":"8286","article_processing_charge":"Yes (via OA deal)","article_type":"original","author":[{"first_name":"Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3650-940X","full_name":"Alistarh, Dan-Adrian","last_name":"Alistarh"},{"id":"3279A00C-F248-11E8-B48F-1D18A9856A87","last_name":"Nadiradze","full_name":"Nadiradze, Giorgi","orcid":"0000-0001-5634-0731","first_name":"Giorgi"},{"id":"bcc145fd-e77f-11ea-ae8b-80d661dbff67","last_name":"Sabour","full_name":"Sabour, Amirmojtaba","first_name":"Amirmojtaba"}],"oa":1,"language":[{"iso":"eng"}],"page":"1007-1029","status":"public","day":"01","type":"journal_article","publication_identifier":{"issn":["0178-4617"],"eissn":["1432-0541"]},"publisher":"Springer Nature","quality_controlled":"1","month":"04"},{"abstract":[{"text":"We prove some recent experimental observations of Dan Reznik concerning periodic billiard orbits in ellipses. For example, the sum of cosines of the angles of a periodic billiard polygon remains constant in the 1-parameter family of such polygons (that exist due to the Poncelet porism). In our proofs, we use geometric and complex analytic methods.","lang":"eng"}],"ec_funded":1,"doi":"10.1007/s40879-020-00426-9","publication_status":"published","department":[{"_id":"HeEd"}],"external_id":{"arxiv":["2001.02934"]},"intvolume":"         8","publication":"European Journal of Mathematics","year":"2022","date_created":"2020-09-20T22:01:38Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2001.02934"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-04-14T07:48:34Z","volume":8,"date_published":"2022-12-01T00:00:00Z","project":[{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Alpha Shape Theory Extended"}],"scopus_import":"1","oa_version":"Preprint","acknowledgement":" This paper would not be written if not for Dan Reznik’s curiosity and persistence; we are very grateful to him. We also thank R. Garcia and J. Koiller for interesting discussions. It is a pleasure to thank the Mathematical Institute of the University of Heidelberg for its stimulating atmosphere. ST thanks M. Bialy for interesting discussions and the Tel Aviv\r\nUniversity for its invariable hospitality. AA was supported by European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 78818 Alpha). RS is supported by NSF Grant DMS-1807320. ST was supported by NSF grant DMS-1510055 and SFB/TRR 191.","title":"Billiards in ellipses revisited","arxiv":1,"citation":{"chicago":"Akopyan, Arseniy, Richard Schwartz, and Serge Tabachnikov. “Billiards in Ellipses Revisited.” <i>European Journal of Mathematics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s40879-020-00426-9\">https://doi.org/10.1007/s40879-020-00426-9</a>.","mla":"Akopyan, Arseniy, et al. “Billiards in Ellipses Revisited.” <i>European Journal of Mathematics</i>, vol. 8, no. 4, Springer Nature, 2022, pp. 1313–27, doi:<a href=\"https://doi.org/10.1007/s40879-020-00426-9\">10.1007/s40879-020-00426-9</a>.","ieee":"A. Akopyan, R. Schwartz, and S. Tabachnikov, “Billiards in ellipses revisited,” <i>European Journal of Mathematics</i>, vol. 8, no. 4. Springer Nature, pp. 1313–1327, 2022.","short":"A. Akopyan, R. Schwartz, S. Tabachnikov, European Journal of Mathematics 8 (2022) 1313–1327.","ama":"Akopyan A, Schwartz R, Tabachnikov S. Billiards in ellipses revisited. <i>European Journal of Mathematics</i>. 2022;8(4):1313-1327. doi:<a href=\"https://doi.org/10.1007/s40879-020-00426-9\">10.1007/s40879-020-00426-9</a>","apa":"Akopyan, A., Schwartz, R., &#38; Tabachnikov, S. (2022). Billiards in ellipses revisited. <i>European Journal of Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40879-020-00426-9\">https://doi.org/10.1007/s40879-020-00426-9</a>","ista":"Akopyan A, Schwartz R, Tabachnikov S. 2022. Billiards in ellipses revisited. European Journal of Mathematics. 8(4), 1313–1327."},"month":"12","quality_controlled":"1","publisher":"Springer Nature","publication_identifier":{"issn":["2199-675X"],"eissn":["2199-6768"]},"day":"01","type":"journal_article","page":"1313-1327","status":"public","oa":1,"language":[{"iso":"eng"}],"author":[{"first_name":"Arseniy","last_name":"Akopyan","full_name":"Akopyan, Arseniy","orcid":"0000-0002-2548-617X","id":"430D2C90-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Richard","last_name":"Schwartz","full_name":"Schwartz, Richard"},{"last_name":"Tabachnikov","full_name":"Tabachnikov, Serge","first_name":"Serge"}],"article_type":"original","article_processing_charge":"No","issue":"4","_id":"8538"},{"date_published":"2022-03-01T00:00:00Z","ddc":["570"],"date_updated":"2026-06-18T19:47:28Z","volume":289,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2022","date_created":"2021-04-18T22:01:43Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/febs.15823"}],"publication":"FEBS Journal","intvolume":"       289","publication_status":"published","department":[{"_id":"CaHe"}],"external_id":{"pmid":["33818917"],"isi":["000636678800001"]},"abstract":[{"text":"Mentorship is experience and/or knowledge‐based guidance. Mentors support, sponsor and advocate for mentees. Having one or more mentors when you seek advice can significantly influence and improve your research endeavours, well‐being and career development. Positive mentee–mentor relationships are vital for maintaining work–life balance and success in careers. Early‐career researchers (ECRs), in particular, can benefit from mentorship to navigate challenges in academic and nonacademic life and careers. Yet, strategies for selecting mentors and maintaining interactions with them are often underdiscussed within research environments. In this Words of Advice, we provide recommendations for ECRs to seek and manage mentorship interactions. Our article draws from our experiences as ECRs and published work, to provide suggestions for mentees to proactively promote beneficial mentorship interactions. The recommended practices highlight the importance of identifying mentorship needs, planning and selecting multiple and diverse mentors, setting goals, and maintaining constructive, and mutually beneficial working relationships with mentors.","lang":"eng"}],"doi":"10.1111/febs.15823","alternative_title":["Words of Advice"],"article_type":"original","article_processing_charge":"No","issue":"6","_id":"9336","oa":1,"language":[{"iso":"eng"}],"author":[{"full_name":"Sarabipour, Sarvenaz","last_name":"Sarabipour","first_name":"Sarvenaz"},{"first_name":"Sarah J.","full_name":"Hainer, Sarah J.","last_name":"Hainer"},{"first_name":"Feyza N","orcid":"0000-0001-5809-9566","full_name":"Arslan, Feyza N","last_name":"Arslan","id":"49DA7910-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Charlotte M.","last_name":"De Winde","full_name":"De Winde, Charlotte M."},{"first_name":"Emily","full_name":"Furlong, Emily","last_name":"Furlong"},{"first_name":"Natalia","last_name":"Bielczyk","full_name":"Bielczyk, Natalia"},{"first_name":"Nafisa M.","full_name":"Jadavji, Nafisa M.","last_name":"Jadavji"},{"first_name":"Aparna P.","last_name":"Shah","full_name":"Shah, Aparna P."},{"full_name":"Davla, Sejal","last_name":"Davla","first_name":"Sejal"}],"day":"01","type":"journal_article","status":"public","page":"1374-1384","quality_controlled":"1","month":"03","publication_identifier":{"issn":["1742-464X"],"eissn":["1742-4658"]},"publisher":"Wiley","pmid":1,"citation":{"ama":"Sarabipour S, Hainer SJ, Arslan FN, et al. Building and sustaining mentor interactions as a mentee. <i>FEBS Journal</i>. 2022;289(6):1374-1384. doi:<a href=\"https://doi.org/10.1111/febs.15823\">10.1111/febs.15823</a>","short":"S. Sarabipour, S.J. Hainer, F.N. Arslan, C.M. De Winde, E. Furlong, N. Bielczyk, N.M. Jadavji, A.P. Shah, S. Davla, FEBS Journal 289 (2022) 1374–1384.","ieee":"S. Sarabipour <i>et al.</i>, “Building and sustaining mentor interactions as a mentee,” <i>FEBS Journal</i>, vol. 289, no. 6. Wiley, pp. 1374–1384, 2022.","ista":"Sarabipour S, Hainer SJ, Arslan FN, De Winde CM, Furlong E, Bielczyk N, Jadavji NM, Shah AP, Davla S. 2022. Building and sustaining mentor interactions as a mentee. FEBS Journal. 289(6), 1374–1384.","apa":"Sarabipour, S., Hainer, S. J., Arslan, F. N., De Winde, C. M., Furlong, E., Bielczyk, N., … Davla, S. (2022). Building and sustaining mentor interactions as a mentee. <i>FEBS Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/febs.15823\">https://doi.org/10.1111/febs.15823</a>","chicago":"Sarabipour, Sarvenaz, Sarah J. Hainer, Feyza N Arslan, Charlotte M. De Winde, Emily Furlong, Natalia Bielczyk, Nafisa M. Jadavji, Aparna P. Shah, and Sejal Davla. “Building and Sustaining Mentor Interactions as a Mentee.” <i>FEBS Journal</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/febs.15823\">https://doi.org/10.1111/febs.15823</a>.","mla":"Sarabipour, Sarvenaz, et al. “Building and Sustaining Mentor Interactions as a Mentee.” <i>FEBS Journal</i>, vol. 289, no. 6, Wiley, 2022, pp. 1374–84, doi:<a href=\"https://doi.org/10.1111/febs.15823\">10.1111/febs.15823</a>."},"title":"Building and sustaining mentor interactions as a mentee","scopus_import":"1","oa_version":"Published Version","acknowledgement":"The authors thank Nicholas Asby of the University of Chicago for valuable comments on an earlier version of this work. A.P.S. was partially supported by the NARSAD Young Investigator Grant 27705. S.J.H was supported by the National Institutes of Health grant R35GM133732.","isi":1},{"isi":1,"acknowledgement":"First and foremost, we acknowledge Siargey Kachanovich for discussions. We thank Herbert Edelsbrunner and all members of his group, all former and current members of the Datashape team (formerly known as Geometrica), and André Lieutier for encouragement. We further thank the reviewers of Foundations of Computational Mathematics and the reviewers and program committee of the Symposium on Computational Geometry for their feedback, which improved the exposition.\r\nThis work was funded by the European Research Council under the European Union’s ERC Grant Agreement number 339025 GUDHI (Algorithmic Foundations of Geometric Understanding in Higher Dimensions). This work was also supported by the French government, through the 3IA Côte d’Azur Investments in the Future project managed by the National Research Agency (ANR) with the reference number ANR-19-P3IA-0002. Mathijs Wintraecken also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 754411.","scopus_import":"1","oa_version":"Published Version","title":"The topological correctness of PL approximations of isomanifolds","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"7952"}]},"has_accepted_license":"1","citation":{"apa":"Boissonnat, J.-D., &#38; Wintraecken, M. (2022). The topological correctness of PL approximations of isomanifolds. <i>Foundations of Computational Mathematics </i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10208-021-09520-0\">https://doi.org/10.1007/s10208-021-09520-0</a>","ista":"Boissonnat J-D, Wintraecken M. 2022. The topological correctness of PL approximations of isomanifolds. Foundations of Computational Mathematics . 22, 967–1012.","short":"J.-D. Boissonnat, M. Wintraecken, Foundations of Computational Mathematics  22 (2022) 967–1012.","ama":"Boissonnat J-D, Wintraecken M. The topological correctness of PL approximations of isomanifolds. <i>Foundations of Computational Mathematics </i>. 2022;22:967-1012. doi:<a href=\"https://doi.org/10.1007/s10208-021-09520-0\">10.1007/s10208-021-09520-0</a>","ieee":"J.-D. Boissonnat and M. Wintraecken, “The topological correctness of PL approximations of isomanifolds,” <i>Foundations of Computational Mathematics </i>, vol. 22. Springer Nature, pp. 967–1012, 2022.","mla":"Boissonnat, Jean-Daniel, and Mathijs Wintraecken. “The Topological Correctness of PL Approximations of Isomanifolds.” <i>Foundations of Computational Mathematics </i>, vol. 22, Springer Nature, 2022, pp. 967–1012, doi:<a href=\"https://doi.org/10.1007/s10208-021-09520-0\">10.1007/s10208-021-09520-0</a>.","chicago":"Boissonnat, Jean-Daniel, and Mathijs Wintraecken. “The Topological Correctness of PL Approximations of Isomanifolds.” <i>Foundations of Computational Mathematics </i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s10208-021-09520-0\">https://doi.org/10.1007/s10208-021-09520-0</a>."},"publisher":"Springer Nature","publication_identifier":{"eissn":["1615-3383"]},"month":"01","quality_controlled":"1","page":"967-1012","status":"public","type":"journal_article","day":"01","author":[{"first_name":"Jean-Daniel","full_name":"Boissonnat, Jean-Daniel","last_name":"Boissonnat"},{"id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","full_name":"Wintraecken, Mathijs","orcid":"0000-0002-7472-2220","last_name":"Wintraecken","first_name":"Mathijs"}],"language":[{"iso":"eng"}],"oa":1,"_id":"9649","corr_author":"1","article_processing_charge":"Yes (via OA deal)","article_type":"original","doi":"10.1007/s10208-021-09520-0","ec_funded":1,"abstract":[{"lang":"eng","text":"Isomanifolds are the generalization of isosurfaces to arbitrary dimension and codimension, i.e. manifolds defined as the zero set of some multivariate vector-valued smooth function f : Rd → Rd−n. A natural (and efficient) way to approximate an isomanifold is to consider its Piecewise-Linear (PL) approximation based on a triangulation T of the ambient space Rd. In this paper, we give conditions under which the PL-approximation of an isomanifold is topologically equivalent to the isomanifold. The conditions are easy to satisfy in the sense that they can always be met by taking a sufficiently\r\nfine triangulation T . This contrasts with previous results on the triangulation of manifolds where, in arbitrary dimensions, delicate perturbations are needed to guarantee topological correctness, which leads to strong limitations in practice. We further give a bound on the Fréchet distance between the original isomanifold and its PL-approximation. Finally we show analogous results for the PL-approximation of an isomanifold with boundary."}],"external_id":{"isi":["000673039600001"]},"department":[{"_id":"HeEd"}],"publication_status":"published","publication":"Foundations of Computational Mathematics ","file":[{"file_name":"Boissonnat-Wintraecken2021_Article_TheTopologicalCorrectnessOfPLA.pdf","file_size":1455699,"date_updated":"2021-07-14T06:44:36Z","access_level":"open_access","creator":"mwintrae","content_type":"application/pdf","date_created":"2021-07-14T06:44:36Z","relation":"main_file","file_id":"9650","checksum":"f1d372ec3c08ec22e84f8e93e1126b8c"}],"intvolume":"        22","file_date_updated":"2021-07-14T06:44:36Z","date_created":"2021-07-14T06:44:53Z","year":"2022","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":22,"date_updated":"2025-04-22T13:45:18Z","ddc":["516"],"project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"date_published":"2022-01-01T00:00:00Z"},{"date_updated":"2025-06-11T13:52:43Z","volume":23,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_published":"2022-07-11T00:00:00Z","project":[{"_id":"25FE9508-B435-11E9-9278-68D0E5697425","grant_number":"724373","call_identifier":"H2020","name":"Cellular Navigation Along Spatial Gradients"}],"ddc":["570"],"year":"2022","date_created":"2021-08-06T09:09:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"creator":"dernst","access_level":"open_access","file_size":11475325,"date_updated":"2022-07-25T07:11:32Z","file_name":"2022_NatureImmunology_Assen.pdf","checksum":"628e7b49809f22c75b428842efe70c68","file_id":"11642","relation":"main_file","date_created":"2022-07-25T07:11:32Z","success":1,"content_type":"application/pdf"}],"intvolume":"        23","publication":"Nature Immunology","file_date_updated":"2022-07-25T07:11:32Z","ec_funded":1,"abstract":[{"text":"Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion.","lang":"eng"}],"doi":"10.1038/s41590-022-01257-4","publication_status":"published","department":[{"_id":"SiHi"},{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"MiSi"}],"external_id":{"pmid":["35817845"],"isi":["000822975900002"]},"oa":1,"language":[{"iso":"eng"}],"author":[{"id":"3A8E7F24-F248-11E8-B48F-1D18A9856A87","last_name":"Assen","full_name":"Assen, Frank P","orcid":"0000-0003-3470-6119","first_name":"Frank P"},{"last_name":"Abe","full_name":"Abe, Jun","first_name":"Jun"},{"last_name":"Hons","full_name":"Hons, Miroslav","orcid":"0000-0002-6625-3348","id":"4167FE56-F248-11E8-B48F-1D18A9856A87","first_name":"Miroslav"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","last_name":"Hauschild","first_name":"Robert"},{"first_name":"Shayan","id":"40B34FE2-F248-11E8-B48F-1D18A9856A87","last_name":"Shamipour","full_name":"Shamipour, Shayan"},{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","full_name":"Kaufmann, Walter","orcid":"0000-0001-9735-5315","first_name":"Walter"},{"orcid":"0000-0001-9732-3815","full_name":"Costanzo, Tommaso","last_name":"Costanzo","id":"D93824F4-D9BA-11E9-BB12-F207E6697425","first_name":"Tommaso"},{"first_name":"Gabriel","full_name":"Krens, Gabriel","orcid":"0000-0003-4761-5996","last_name":"Krens","id":"2B819732-F248-11E8-B48F-1D18A9856A87"},{"id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87","last_name":"Brown","full_name":"Brown, Markus","first_name":"Markus"},{"first_name":"Burkhard","full_name":"Ludewig, Burkhard","last_name":"Ludewig"},{"first_name":"Simon","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"},{"first_name":"Wolfgang","full_name":"Weninger, Wolfgang","last_name":"Weninger"},{"first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B"},{"first_name":"Sanjiv A.","full_name":"Luther, Sanjiv A.","last_name":"Luther"},{"full_name":"Stein, Jens V.","last_name":"Stein","first_name":"Jens V."},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-4561-241X","full_name":"Sixt, Michael K","first_name":"Michael K"}],"article_type":"original","article_processing_charge":"No","_id":"9794","corr_author":"1","month":"07","quality_controlled":"1","publication_identifier":{"issn":["1529-2908"],"eissn":["1529-2916"]},"publisher":"Springer Nature","day":"11","type":"journal_article","status":"public","page":"1246-1255","citation":{"short":"F.P. Assen, J. Abe, M. Hons, R. Hauschild, S. Shamipour, W. Kaufmann, T. Costanzo, G. Krens, M. Brown, B. Ludewig, S. Hippenmeyer, C.-P.J. Heisenberg, W. Weninger, E.B. Hannezo, S.A. Luther, J.V. Stein, M.K. Sixt, Nature Immunology 23 (2022) 1246–1255.","ieee":"F. P. Assen <i>et al.</i>, “Multitier mechanics control stromal adaptations in swelling lymph nodes,” <i>Nature Immunology</i>, vol. 23. Springer Nature, pp. 1246–1255, 2022.","ama":"Assen FP, Abe J, Hons M, et al. Multitier mechanics control stromal adaptations in swelling lymph nodes. <i>Nature Immunology</i>. 2022;23:1246-1255. doi:<a href=\"https://doi.org/10.1038/s41590-022-01257-4\">10.1038/s41590-022-01257-4</a>","ista":"Assen FP, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann W, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg C-PJ, Weninger W, Hannezo EB, Luther SA, Stein JV, Sixt MK. 2022. Multitier mechanics control stromal adaptations in swelling lymph nodes. Nature Immunology. 23, 1246–1255.","apa":"Assen, F. P., Abe, J., Hons, M., Hauschild, R., Shamipour, S., Kaufmann, W., … Sixt, M. K. (2022). Multitier mechanics control stromal adaptations in swelling lymph nodes. <i>Nature Immunology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41590-022-01257-4\">https://doi.org/10.1038/s41590-022-01257-4</a>","chicago":"Assen, Frank P, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter Kaufmann, Tommaso Costanzo, et al. “Multitier Mechanics Control Stromal Adaptations in Swelling Lymph Nodes.” <i>Nature Immunology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41590-022-01257-4\">https://doi.org/10.1038/s41590-022-01257-4</a>.","mla":"Assen, Frank P., et al. “Multitier Mechanics Control Stromal Adaptations in Swelling Lymph Nodes.” <i>Nature Immunology</i>, vol. 23, Springer Nature, 2022, pp. 1246–55, doi:<a href=\"https://doi.org/10.1038/s41590-022-01257-4\">10.1038/s41590-022-01257-4</a>."},"has_accepted_license":"1","pmid":1,"oa_version":"Published Version","acknowledgement":"This research was supported by the Scientific Service Units of IST Austria through resources provided by the Imaging and Optics, Electron Microscopy, Preclinical and Life Science Facilities. We thank C. Moussion for providing anti-PNAd antibody and D. Critchley for Talin1-floxed mice, and E. Papusheva for providing a custom 3D channel alignment script. This work was supported by a European Research Council grant ERC-CoG-72437 to M.S. M.H. was supported by Czech Sciencundation GACR 20-24603Y and Charles University PRIMUS/20/MED/013.","scopus_import":"1","isi":1,"title":"Multitier mechanics control stromal adaptations in swelling lymph nodes","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"PreCl"},{"_id":"LifeSc"}]},{"oa_version":"None","scopus_import":"1","acknowledgement":"This work was supported by FONDECYT grants 1151432 and 1210169 to Gonzalo J. Marín. FONDECYT grant 1210069 to Jorge Mpodozis. Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Fund (FEDER), PGC2018-098229-B-100 to José L Ferrán. Spanish Ministry of Economy and Competitiveness Excellency Grant BFU2014-57516P (with European Community FEDER support), and a Seneca Foundation (Autonomous Community of Murcia) Excellency Research contract, ref: 19904/ GERM/15; project name: Genoarchitectonic Brain Development and Applications to Neurodegenerative Diseases and Cancer (5672 Fundación Séneca) to Luis Puelles. The authors gratefully acknowledge the valuable editorial help provided by Sara Fernández-Collemann. The authors also thank Elisa Sentis and Solano Henríquez for expert technical help.","isi":1,"title":"Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum","citation":{"mla":"Reyes‐Pinto, Rosana, et al. “Change in the Neurochemical Signature and Morphological Development of the Parvocellular Isthmic Projection to the Avian Tectum.” <i>Journal of Comparative Neurology</i>, vol. 530, no. 2, Wiley, 2022, pp. 553–73, doi:<a href=\"https://doi.org/10.1002/cne.25229\">10.1002/cne.25229</a>.","chicago":"Reyes‐Pinto, Rosana, José L. Ferrán, Tomas A Vega Zuniga, Cristian González‐Cabrera, Harald Luksch, Jorge Mpodozis, Luis Puelles, and Gonzalo J. Marín. “Change in the Neurochemical Signature and Morphological Development of the Parvocellular Isthmic Projection to the Avian Tectum.” <i>Journal of Comparative Neurology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1002/cne.25229\">https://doi.org/10.1002/cne.25229</a>.","short":"R. Reyes‐Pinto, J.L. Ferrán, T.A. Vega Zuniga, C. González‐Cabrera, H. Luksch, J. Mpodozis, L. Puelles, G.J. Marín, Journal of Comparative Neurology 530 (2022) 553–573.","ieee":"R. Reyes‐Pinto <i>et al.</i>, “Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum,” <i>Journal of Comparative Neurology</i>, vol. 530, no. 2. Wiley, pp. 553–573, 2022.","ama":"Reyes‐Pinto R, Ferrán JL, Vega Zuniga TA, et al. Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. <i>Journal of Comparative Neurology</i>. 2022;530(2):553-573. doi:<a href=\"https://doi.org/10.1002/cne.25229\">10.1002/cne.25229</a>","ista":"Reyes‐Pinto R, Ferrán JL, Vega Zuniga TA, González‐Cabrera C, Luksch H, Mpodozis J, Puelles L, Marín GJ. 2022. Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. Journal of Comparative Neurology. 530(2), 553–573.","apa":"Reyes‐Pinto, R., Ferrán, J. L., Vega Zuniga, T. A., González‐Cabrera, C., Luksch, H., Mpodozis, J., … Marín, G. J. (2022). Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. <i>Journal of Comparative Neurology</i>. Wiley. <a href=\"https://doi.org/10.1002/cne.25229\">https://doi.org/10.1002/cne.25229</a>"},"pmid":1,"month":"02","quality_controlled":"1","publication_identifier":{"issn":["0021-9967"],"eissn":["1096-9861"]},"publisher":"Wiley","day":"01","type":"journal_article","status":"public","page":"553-573","language":[{"iso":"eng"}],"author":[{"first_name":"Rosana","full_name":"Reyes‐Pinto, Rosana","last_name":"Reyes‐Pinto"},{"last_name":"Ferrán","full_name":"Ferrán, José L.","first_name":"José L."},{"first_name":"Tomas A","full_name":"Vega Zuniga, Tomas A","last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"full_name":"González‐Cabrera, Cristian","last_name":"González‐Cabrera","first_name":"Cristian"},{"first_name":"Harald","full_name":"Luksch, Harald","last_name":"Luksch"},{"first_name":"Jorge","last_name":"Mpodozis","full_name":"Mpodozis, Jorge"},{"first_name":"Luis","last_name":"Puelles","full_name":"Puelles, Luis"},{"first_name":"Gonzalo J.","last_name":"Marín","full_name":"Marín, Gonzalo J."}],"article_processing_charge":"No","article_type":"original","_id":"9955","issue":"2","abstract":[{"lang":"eng","text":"Neurons can change their classical neurotransmitters during ontogeny, sometimes going through stages of dual release. Here, we explored the development of the neurotransmitter identity of neurons of the avian nucleus isthmi parvocellularis (Ipc), whose axon terminals are retinotopically arranged in the optic tectum (TeO) and exert a focal gating effect upon the ascending transmission of retinal inputs. Although cholinergic and glutamatergic markers are both found in Ipc neurons and terminals of adult pigeons and chicks, the mRNA expression of the vesicular acetylcholine transporter, VAChT, is weak or absent. To explore how the Ipc neurotransmitter identity is established during ontogeny, we analyzed the expression of mRNAs coding for cholinergic (ChAT, VAChT, and CHT) and glutamatergic (VGluT2 and VGluT3) markers in chick embryos at different developmental stages. We found that between E12 and E18, Ipc neurons expressed all cholinergic mRNAs and also VGluT2 mRNA; however, from E16 through posthatch stages, VAChT mRNA expression was specifically diminished. Our ex vivo deposits of tracer crystals and intracellular filling experiments revealed that Ipc axons exhibit a mature paintbrush morphology late in development, experiencing marked morphological transformations during the period of presumptive dual vesicular transmitter release. Additionally, although ChAT protein immunoassays increasingly label the growing Ipc axon, this labeling was consistently restricted to sparse portions of the terminal branches. Combined, these results suggest that the synthesis of glutamate and acetylcholine, and their vesicular release, is complexly linked to the developmental processes of branching, growing and remodeling of these unique axons."}],"doi":"10.1002/cne.25229","publication_status":"published","department":[{"_id":"MaJö"}],"external_id":{"pmid":["34363623"],"isi":["000686420000001"]},"intvolume":"       530","publication":"Journal of Comparative Neurology","year":"2022","date_created":"2021-08-23T08:40:59Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-11T10:58:17Z","volume":530,"date_published":"2022-02-01T00:00:00Z"},{"day":"01","type":"journal_article","page":"709-764","status":"public","quality_controlled":"1","month":"03","publication_identifier":{"eissn":["1469-7750"]},"publisher":"Wiley","article_processing_charge":"Yes (via OA deal)","article_type":"original","_id":"9977","issue":"2","corr_author":"1","language":[{"iso":"eng"}],"oa":1,"author":[{"id":"41B03CD0-62AE-11E9-84EF-0718E6697425","full_name":"Mistegaard, William","last_name":"Mistegaard","first_name":"William"},{"full_name":"Andersen, Jørgen Ellegaard","last_name":"Andersen","first_name":"Jørgen Ellegaard"}],"title":"Resurgence analysis of quantum invariants of Seifert fibered homology spheres","scopus_import":"1","oa_version":"Published Version","acknowledgement":"We warmly thank S. Gukov for valuable discussions on the GPPV invariant ̂Z𝑎(𝑀3; 𝑞). The first\r\nauthor was supported in part by the center of excellence grant ‘Center for Quantum Geometry\r\nof Moduli Spaces’ from the Danish National Research Foundation (DNRF95) and by the ERCSynergy\r\ngrant ‘ReNewQuantum’. The second author received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 754411.","isi":1,"arxiv":1,"citation":{"chicago":"Mistegaard, William, and Jørgen Ellegaard Andersen. “Resurgence Analysis of Quantum Invariants of Seifert Fibered Homology Spheres.” <i>Journal of the London Mathematical Society</i>. Wiley, 2022. <a href=\"https://doi.org/10.1112/jlms.12506\">https://doi.org/10.1112/jlms.12506</a>.","mla":"Mistegaard, William, and Jørgen Ellegaard Andersen. “Resurgence Analysis of Quantum Invariants of Seifert Fibered Homology Spheres.” <i>Journal of the London Mathematical Society</i>, vol. 105, no. 2, Wiley, 2022, pp. 709–64, doi:<a href=\"https://doi.org/10.1112/jlms.12506\">10.1112/jlms.12506</a>.","ista":"Mistegaard W, Andersen JE. 2022. Resurgence analysis of quantum invariants of Seifert fibered homology spheres. Journal of the London Mathematical Society. 105(2), 709–764.","apa":"Mistegaard, W., &#38; Andersen, J. E. (2022). Resurgence analysis of quantum invariants of Seifert fibered homology spheres. <i>Journal of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/jlms.12506\">https://doi.org/10.1112/jlms.12506</a>","ama":"Mistegaard W, Andersen JE. Resurgence analysis of quantum invariants of Seifert fibered homology spheres. <i>Journal of the London Mathematical Society</i>. 2022;105(2):709-764. doi:<a href=\"https://doi.org/10.1112/jlms.12506\">10.1112/jlms.12506</a>","short":"W. Mistegaard, J.E. Andersen, Journal of the London Mathematical Society 105 (2022) 709–764.","ieee":"W. Mistegaard and J. E. Andersen, “Resurgence analysis of quantum invariants of Seifert fibered homology spheres,” <i>Journal of the London Mathematical Society</i>, vol. 105, no. 2. Wiley, pp. 709–764, 2022."},"has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","year":"2022","date_created":"2021-08-31T12:51:40Z","date_published":"2022-03-01T00:00:00Z","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"}],"ddc":["510"],"date_updated":"2025-04-14T07:43:49Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":105,"publication_status":"published","department":[{"_id":"TaHa"}],"external_id":{"arxiv":["1811.05376"],"isi":["000755205700001"]},"ec_funded":1,"abstract":[{"text":"For a Seifert fibered homology sphere X we show that the q-series invariant Zˆ0(X; q) introduced by Gukov-Pei-Putrov-Vafa, is a resummation of the Ohtsuki series Z0(X). We show that for every even k ∈ N there exists a full asymptotic expansion of Zˆ0(X; q) for q tending to e 2πi/k, and in particular that the limit Zˆ0(X; e 2πi/k) exists and is equal to the\r\nWRT quantum invariant τk(X). We show that the poles of the Borel transform of Z0(X) coincide with the classical complex Chern-Simons values, which we further show classifies the corresponding components of the moduli space of flat SL(2, C)-connections.","lang":"eng"}],"doi":"10.1112/jlms.12506","file_date_updated":"2022-03-24T11:42:25Z","intvolume":"       105","file":[{"date_created":"2022-03-24T11:42:25Z","success":1,"content_type":"application/pdf","file_id":"10917","checksum":"9c72327d39f34f1a6eaa98fa4b8493f2","relation":"main_file","access_level":"open_access","date_updated":"2022-03-24T11:42:25Z","file_name":"2022_JourLondonMathSoc_Andersen.pdf","file_size":649130,"creator":"dernst"}],"publication":"Journal of the London Mathematical Society"},{"month":"03","year":"2022","date_created":"2024-10-09T19:35:03Z","publisher":"Institute of Science and Technology Austria","day":"01","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","status":"public","date_updated":"2025-04-15T07:15:24Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"author":[{"last_name":"Katsaros","orcid":"0000-0001-8342-202X","full_name":"Katsaros, Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios"},{"first_name":"Daniel","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7197-4801","full_name":"Jirovec, Daniel","last_name":"Jirovec"}],"date_published":"2022-03-01T00:00:00Z","article_processing_charge":"No","corr_author":"1","_id":"18291","oa_version":"None","doi":"10.15479/AT:ISTA:18291","title":"Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences","related_material":{"record":[{"status":"public","relation":"research_paper","id":"10920"}]},"department":[{"_id":"GeKa"}],"citation":{"mla":"Katsaros, Georgios, and Daniel Jirovec. <i>Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>.","chicago":"Katsaros, Georgios, and Daniel Jirovec. “Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>.","ama":"Katsaros G, Jirovec D. Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>","short":"G. Katsaros, D. Jirovec, (2022).","ieee":"G. Katsaros and D. Jirovec, “Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences.” Institute of Science and Technology Austria, 2022.","apa":"Katsaros, G., &#38; Jirovec, D. (2022). Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>","ista":"Katsaros G, Jirovec D. 2022. Dynamics of Hole Singlet-Triplet Qubits with Large 𝑔-Factor Differences, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>."},"file":[{"date_created":"2024-10-09T19:31:35Z","content_type":"application/x-zip-compressed","success":1,"file_id":"18292","checksum":"3128dffbd09267b93c2d0b1425fd3ba2","relation":"main_file","access_level":"open_access","file_size":25566516,"file_name":"SOIPaper.zip","date_updated":"2024-10-09T19:31:35Z","creator":"gkatsaro"},{"creator":"gkatsaro","file_size":6776,"date_updated":"2024-10-14T18:11:45Z","file_name":"Readme.txt","access_level":"open_access","relation":"main_file","checksum":"df077d2f4652afeb3bf100068e88aa48","file_id":"18442","success":1,"content_type":"text/plain","date_created":"2024-10-14T18:11:45Z"}],"has_accepted_license":"1","file_date_updated":"2024-10-14T18:11:45Z"},{"day":"26","type":"journal_article","status":"public","page":"1735-1803","month":"11","quality_controlled":"1","publication_identifier":{"issn":["1660-8933"],"eissn":["1660-8941"]},"publisher":"EMS Press","article_type":"original","article_processing_charge":"No","corr_author":"1","_id":"17063","issue":"3","oa":1,"language":[{"iso":"eng"}],"author":[{"first_name":"Marie-Claude","last_name":"Arnaud","full_name":"Arnaud, Marie-Claude"},{"full_name":"Hofer, Helmut W.","last_name":"Hofer","first_name":"Helmut W."},{"full_name":"Hutchings, Michael","last_name":"Hutchings","first_name":"Michael"},{"id":"FE553552-CDE8-11E9-B324-C0EBE5697425","full_name":"Kaloshin, Vadim","orcid":"0000-0002-6051-2628","last_name":"Kaloshin","first_name":"Vadim"}],"title":"Dynamische Systeme","scopus_import":"1","oa_version":"Published Version","citation":{"ista":"Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. 2022. Dynamische Systeme. Oberwolfach Reports. 18(3), 1735–1803.","apa":"Arnaud, M.-C., Hofer, H. W., Hutchings, M., &#38; Kaloshin, V. (2022). Dynamische Systeme. <i>Oberwolfach Reports</i>. EMS Press. <a href=\"https://doi.org/10.4171/owr/2021/33\">https://doi.org/10.4171/owr/2021/33</a>","ieee":"M.-C. Arnaud, H. W. Hofer, M. Hutchings, and V. Kaloshin, “Dynamische Systeme,” <i>Oberwolfach Reports</i>, vol. 18, no. 3. EMS Press, pp. 1735–1803, 2022.","ama":"Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. Dynamische Systeme. <i>Oberwolfach Reports</i>. 2022;18(3):1735-1803. doi:<a href=\"https://doi.org/10.4171/owr/2021/33\">10.4171/owr/2021/33</a>","short":"M.-C. Arnaud, H.W. Hofer, M. Hutchings, V. Kaloshin, Oberwolfach Reports 18 (2022) 1735–1803.","mla":"Arnaud, Marie-Claude, et al. “Dynamische Systeme.” <i>Oberwolfach Reports</i>, vol. 18, no. 3, EMS Press, 2022, pp. 1735–803, doi:<a href=\"https://doi.org/10.4171/owr/2021/33\">10.4171/owr/2021/33</a>.","chicago":"Arnaud, Marie-Claude, Helmut W. Hofer, Michael Hutchings, and Vadim Kaloshin. “Dynamische Systeme.” <i>Oberwolfach Reports</i>. EMS Press, 2022. <a href=\"https://doi.org/10.4171/owr/2021/33\">https://doi.org/10.4171/owr/2021/33</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2022","date_created":"2024-05-29T06:01:19Z","main_file_link":[{"open_access":"1","url":"https://www.doi.org/10.4171/OWR/2021/33"}],"date_published":"2022-11-26T00:00:00Z","ddc":["500"],"date_updated":"2026-07-06T11:52:32Z","volume":18,"publication_status":"published","department":[{"_id":"VaKa"}],"abstract":[{"text":"This workshop continued a biannual series of workshops at Oberwolfach on dynamical systems that started with a meeting organized by Moser and Zehnder in 1981. Workshops in this series focus on new results and developments in dynamical systems and related areas of mathematics, with symplectic geometry playing an important role in recent years in connection with Hamiltonian dynamics. In this year special emphasis was placed on various kinds of spectra (in contact geometry, in Riemannian geometry, in dynamical systems and in symplectic topology) and their applications to dynamics.","lang":"eng"}],"das_tickbox":"1","doi":"10.4171/owr/2021/33","intvolume":"        18","publication":"Oberwolfach Reports"},{"issue":"1","_id":"10042","corr_author":"1","keyword":["tin selenide","nanocomposite","grain growth","Zener pinning","thermoelectricity","annealing","solution processing"],"article_processing_charge":"Yes (via OA deal)","article_type":"original","author":[{"first_name":"Yu","last_name":"Liu","full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","id":"2A70014E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mariano","orcid":"0000-0003-4566-5877","full_name":"Calcabrini, Mariano","last_name":"Calcabrini","id":"45D7531A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Yuan","full_name":"Yu, Yuan","last_name":"Yu"},{"first_name":"Seungho","last_name":"Lee","full_name":"Lee, Seungho","orcid":"0000-0002-6962-8598","id":"BB243B88-D767-11E9-B658-BC13E6697425"},{"id":"9E331C2E-9F27-11E9-AE48-5033E6697425","orcid":"0000-0002-9515-4277","full_name":"Chang, Cheng","last_name":"Chang","first_name":"Cheng"},{"first_name":"Jérémy","last_name":"David","full_name":"David, Jérémy"},{"first_name":"Tanmoy","id":"a5fc9bc3-feff-11ea-93fe-e8015a3c7e9d","full_name":"Ghosh, Tanmoy","last_name":"Ghosh"},{"first_name":"Maria Chiara","last_name":"Spadaro","full_name":"Spadaro, Maria Chiara"},{"first_name":"Chenyang","full_name":"Xie, Chenyang","last_name":"Xie"},{"last_name":"Cojocaru-Mirédin","full_name":"Cojocaru-Mirédin, Oana","first_name":"Oana"},{"first_name":"Jordi","last_name":"Arbiol","full_name":"Arbiol, Jordi"},{"first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","last_name":"Ibáñez"}],"language":[{"iso":"eng"}],"oa":1,"status":"public","page":"78-88","day":"25","type":"journal_article","publication_identifier":{"eissn":["1936-086X"],"issn":["1936-0851"]},"publisher":"American Chemical Society","quality_controlled":"1","month":"01","pmid":1,"has_accepted_license":"1","citation":{"chicago":"Liu, Yu, Mariano Calcabrini, Yuan Yu, Seungho Lee, Cheng Chang, Jérémy David, Tanmoy Ghosh, et al. “Defect Engineering in Solution-Processed Polycrystalline SnSe Leads to High Thermoelectric Performance.” <i>ACS Nano</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acsnano.1c06720\">https://doi.org/10.1021/acsnano.1c06720</a>.","mla":"Liu, Yu, et al. “Defect Engineering in Solution-Processed Polycrystalline SnSe Leads to High Thermoelectric Performance.” <i>ACS Nano</i>, vol. 16, no. 1, American Chemical Society, 2022, pp. 78–88, doi:<a href=\"https://doi.org/10.1021/acsnano.1c06720\">10.1021/acsnano.1c06720</a>.","ama":"Liu Y, Calcabrini M, Yu Y, et al. Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. <i>ACS Nano</i>. 2022;16(1):78-88. doi:<a href=\"https://doi.org/10.1021/acsnano.1c06720\">10.1021/acsnano.1c06720</a>","short":"Y. Liu, M. Calcabrini, Y. Yu, S. Lee, C. Chang, J. David, T. Ghosh, M.C. Spadaro, C. Xie, O. Cojocaru-Mirédin, J. Arbiol, M. Ibáñez, ACS Nano 16 (2022) 78–88.","ieee":"Y. Liu <i>et al.</i>, “Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance,” <i>ACS Nano</i>, vol. 16, no. 1. American Chemical Society, pp. 78–88, 2022.","apa":"Liu, Y., Calcabrini, M., Yu, Y., Lee, S., Chang, C., David, J., … Ibáñez, M. (2022). Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. <i>ACS Nano</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsnano.1c06720\">https://doi.org/10.1021/acsnano.1c06720</a>","ista":"Liu Y, Calcabrini M, Yu Y, Lee S, Chang C, David J, Ghosh T, Spadaro MC, Xie C, Cojocaru-Mirédin O, Arbiol J, Ibáñez M. 2022. Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. ACS Nano. 16(1), 78–88."},"title":"Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"12885"}]},"isi":1,"acknowledgement":"This work was financially supported by IST Austria and the Werner Siemens Foundation. Y.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 754411. S.L. and M.C. received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 665385. J.D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 665919 (P-SPHERE) cofunded by Severo Ochoa Programme. C.C. acknowledges funding from the FWF “Lise Meitner Fellowship” grant agreement M 2889-N. Y.Y. and O.C.-M. acknowledge the financial support from DFG within the project SFB 917: Nanoswitches. M.C.S. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754510 (PROBIST) and the Severo Ochoa programme. J.D. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 665919 (P-SPHERE) cofunded by Severo Ochoa Programme. The ICN2 is funded by the CERCA Program/Generalitat de Catalunya and by the Severo Ochoa program of the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO, grant no. SEV-2017-0706). ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project NANOGEN (PID2020-116093RB-C43). This project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 823717-ESTEEM3. The FIB sample preparation was conducted in the LMA-INA-Universidad de Zaragoza.","scopus_import":"1","oa_version":"Published Version","date_published":"2022-01-25T00:00:00Z","ddc":["540"],"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"},{"name":"Bottom-up Engineering for Thermoelectric Applications","grant_number":"M02889","_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A"}],"date_updated":"2026-07-06T12:16:06Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":16,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-09-24T07:55:12Z","year":"2022","file_date_updated":"2022-03-02T16:17:29Z","publication":"ACS Nano","intvolume":"        16","file":[{"date_created":"2022-03-02T16:17:29Z","success":1,"content_type":"application/pdf","checksum":"74f9c1aa5f95c0b992a4328e8e0247b4","file_id":"10808","relation":"main_file","access_level":"open_access","date_updated":"2022-03-02T16:17:29Z","file_size":9050764,"file_name":"2022_ACSNano_Liu.pdf","creator":"cchlebak"}],"department":[{"_id":"MaIb"}],"external_id":{"pmid":["34549956"],"isi":["000767223400008"]},"publication_status":"published","das_tickbox":"1","doi":"10.1021/acsnano.1c06720","abstract":[{"lang":"eng","text":"SnSe has emerged as one of the most promising materials for thermoelectric energy conversion due to its extraordinary performance in its single-crystal form and its low-cost constituent elements. However, to achieve an economic impact, the polycrystalline counterpart needs to replicate the performance of the single crystal. Herein, we optimize the thermoelectric performance of polycrystalline SnSe produced by consolidating solution-processed and surface-engineered SnSe particles. In particular, the SnSe particles are coated with CdSe molecular complexes that crystallize during the sintering process, forming CdSe nanoparticles. The presence of CdSe nanoparticles inhibits SnSe grain growth during the consolidation step due to Zener pinning, yielding a material with a high density of grain boundaries. Moreover, the resulting SnSe–CdSe nanocomposites present a large number of defects at different length scales, which significantly reduce the thermal conductivity. The produced SnSe–CdSe nanocomposites exhibit thermoelectric figures of merit up to 2.2 at 786 K, which is among the highest reported for solution-processed SnSe."}],"ec_funded":1},{"year":"2022","date_created":"2022-02-20T23:01:31Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":119,"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"date_updated":"2026-07-06T12:45:39Z","ddc":["570"],"project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation"},{"name":"Modulation of adhesion function in cell-cell contact formation by cortical tension","grant_number":"187-2013","_id":"2521E28E-B435-11E9-9278-68D0E5697425"}],"date_published":"2022-02-14T00:00:00Z","abstract":[{"lang":"eng","text":"Tension of the actomyosin cell cortex plays a key role in determining cell–cell contact growth and size. The level of cortical tension outside of the cell–cell contact, when pulling at the contact edge, scales with the total size to which a cell–cell contact can grow [J.-L. Maître et al., Science 338, 253–256 (2012)]. Here, we show in zebrafish primary germ-layer progenitor cells that this monotonic relationship only applies to a narrow range of cortical tension increase and that above a critical threshold, contact size inversely scales with cortical tension. This switch from cortical tension increasing to decreasing progenitor cell–cell contact size is caused by cortical tension promoting E-cadherin anchoring to the actomyosin cytoskeleton, thereby increasing clustering and stability of E-cadherin at the contact. After tension-mediated E-cadherin stabilization at the contact exceeds a critical threshold level, the rate by which the contact expands in response to pulling forces from the cortex sharply drops, leading to smaller contacts at physiologically relevant timescales of contact formation. Thus, the activity of cortical tension in expanding cell–cell contact size is limited by tension-stabilizing E-cadherin–actin complexes at the contact."}],"ec_funded":1,"doi":"10.1073/pnas.2122030119","publication_status":"published","external_id":{"pmid":["35165179"],"isi":["000766926900009"]},"department":[{"_id":"CaHe"},{"_id":"EM-Fac"},{"_id":"Bio"}],"publication":"Proceedings of the National Academy of Sciences of the United States of America","intvolume":"       119","file":[{"checksum":"d49f83c3580613966f71768ddb9a55a5","file_id":"10780","relation":"main_file","date_created":"2022-02-21T08:45:11Z","content_type":"application/pdf","success":1,"creator":"dernst","access_level":"open_access","date_updated":"2022-02-21T08:45:11Z","file_size":1609678,"file_name":"2022_PNAS_Slovakova.pdf"}],"file_date_updated":"2022-02-21T08:45:11Z","month":"02","quality_controlled":"1","publication_identifier":{"eissn":["1091-6490"]},"publisher":"National Academy of Sciences","article_number":"e2122030119","type":"journal_article","day":"14","status":"public","language":[{"iso":"eng"}],"oa":1,"author":[{"full_name":"Slovakova, Jana","last_name":"Slovakova","id":"30F3F2F0-F248-11E8-B48F-1D18A9856A87","first_name":"Jana"},{"last_name":"Sikora","full_name":"Sikora, Mateusz K","id":"2F74BCDE-F248-11E8-B48F-1D18A9856A87","first_name":"Mateusz K"},{"first_name":"Feyza N","last_name":"Arslan","orcid":"0000-0001-5809-9566","full_name":"Arslan, Feyza N","id":"49DA7910-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Silvia","full_name":"Caballero Mancebo, Silvia","orcid":"0000-0002-5223-3346","last_name":"Caballero Mancebo","id":"2F1E1758-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Gabriel","id":"2B819732-F248-11E8-B48F-1D18A9856A87","full_name":"Krens, Gabriel","orcid":"0000-0003-4761-5996","last_name":"Krens"},{"full_name":"Kaufmann, Walter","orcid":"0000-0001-9735-5315","last_name":"Kaufmann","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter"},{"first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","orcid":"0000-0001-5145-4609","full_name":"Merrin, Jack"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J"}],"article_type":"original","article_processing_charge":"No","_id":"10766","corr_author":"1","issue":"8","scopus_import":"1","acknowledgement":"We thank Guillaume Salbreaux, Silvia Grigolon, Edouard Hannezo, and Vanessa Barone for discussions and comments on the manuscript and Shayan Shamipour and Daniel Capek for help with data analysis. We also thank the Imaging & Optics, Electron Microscopy, and Zebrafish Facility Scientific Service Units at the Institute of Science and Technology Austria (ISTA)Nasser Darwish-Miranda  for continuous support. We acknowledge Hitoshi Morita for the gift of VinculinB-GFP plasmid. This research was supported by an ISTA Fellow Marie-Curie Co-funding of regional, national, and international programmes Grant P_IST_EU01 (to J.S.), European Molecular Biology Organization Long-Term Fellowship Grant, ALTF reference number: 187-2013 (to M.S.), Schroedinger Fellowship J4332-B28 (to M.S.), and European Research Council Advanced Grant (MECSPEC; to C.-P.H.).","oa_version":"Published Version","isi":1,"title":"Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells","related_material":{"record":[{"id":"9750","status":"public","relation":"earlier_version"}]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"PreCl"}],"citation":{"ista":"Slovakova J, Sikora MK, Arslan FN, Caballero Mancebo S, Krens G, Kaufmann W, Merrin J, Heisenberg C-PJ. 2022. Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 119(8), e2122030119.","apa":"Slovakova, J., Sikora, M. K., Arslan, F. N., Caballero Mancebo, S., Krens, G., Kaufmann, W., … Heisenberg, C.-P. J. (2022). Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2122030119\">https://doi.org/10.1073/pnas.2122030119</a>","ieee":"J. Slovakova <i>et al.</i>, “Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 8. National Academy of Sciences, 2022.","short":"J. Slovakova, M.K. Sikora, F.N. Arslan, S. Caballero Mancebo, G. Krens, W. Kaufmann, J. Merrin, C.-P.J. Heisenberg, Proceedings of the National Academy of Sciences of the United States of America 119 (2022).","ama":"Slovakova J, Sikora MK, Arslan FN, et al. Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2022;119(8). doi:<a href=\"https://doi.org/10.1073/pnas.2122030119\">10.1073/pnas.2122030119</a>","chicago":"Slovakova, Jana, Mateusz K Sikora, Feyza N Arslan, Silvia Caballero Mancebo, Gabriel Krens, Walter Kaufmann, Jack Merrin, and Carl-Philipp J Heisenberg. “Tension-Dependent Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion in Zebrafish Germ-Layer Progenitor Cells.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2022. <a href=\"https://doi.org/10.1073/pnas.2122030119\">https://doi.org/10.1073/pnas.2122030119</a>.","mla":"Slovakova, Jana, et al. “Tension-Dependent Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion in Zebrafish Germ-Layer Progenitor Cells.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 8, e2122030119, National Academy of Sciences, 2022, doi:<a href=\"https://doi.org/10.1073/pnas.2122030119\">10.1073/pnas.2122030119</a>."},"has_accepted_license":"1","pmid":1},{"type":"journal_article","day":"26","status":"public","quality_controlled":"1","month":"07","publisher":"eLife Sciences Publications","article_number":"e78995","publication_identifier":{"eissn":["2050-084X"]},"article_type":"original","article_processing_charge":"Yes","corr_author":"1","_id":"11843","language":[{"iso":"eng"}],"oa":1,"author":[{"first_name":"Kathrin","id":"3AEC8556-F248-11E8-B48F-1D18A9856A87","last_name":"Tomasek","orcid":"0000-0003-3768-877X","full_name":"Tomasek, Kathrin"},{"full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X","last_name":"Leithner","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander F"},{"id":"727b3c7d-4939-11ec-89b3-b9b0750ab74d","full_name":"Glatzová, Ivana","last_name":"Glatzová","first_name":"Ivana"},{"full_name":"Lukesch, Michael S.","last_name":"Lukesch","first_name":"Michael S."},{"first_name":"Calin C","full_name":"Guet, Calin C","orcid":"0000-0001-6220-2052","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K"}],"related_material":{"record":[{"id":"10316","relation":"earlier_version","status":"public"}]},"title":"Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"EM-Fac"}],"oa_version":"Published Version","scopus_import":"1","acknowledgement":"We thank Ulrich Dobrindt for providing UPEC strains CFT073, UTI89, and 536, Frank Assen, Vlad Gavra, Maximilian Götz, Bor Kavčič, Jonna Alanko, and Eva Kiermaier for help with experiments and Robert Hauschild, Julian Stopp, and Saren Tasciyan for help with data analysis. We thank the IST Austria Scientific Service Units, especially the Bioimaging facility, the Preclinical facility and the Electron microscopy facility for technical support, Jakob Wallner and all members of the Guet and Sixt lab for fruitful discussions and Daria Siekhaus for critically reading the manuscript. This work was supported by grants from the Austrian Research Promotion Agency (FEMtech 868984) to IG, the European Research Council (CoG 724373), and the Austrian Science Fund (FWF P29911) to MS.","isi":1,"pmid":1,"citation":{"apa":"Tomasek, K., Leithner, A. F., Glatzová, I., Lukesch, M. S., Guet, C. C., &#38; Sixt, M. K. (2022). Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.78995\">https://doi.org/10.7554/eLife.78995</a>","ista":"Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. 2022. Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14. eLife. 11, e78995.","ieee":"K. Tomasek, A. F. Leithner, I. Glatzová, M. S. Lukesch, C. C. Guet, and M. K. Sixt, “Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14,” <i>eLife</i>, vol. 11. eLife Sciences Publications, 2022.","short":"K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, ELife 11 (2022).","ama":"Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14. <i>eLife</i>. 2022;11. doi:<a href=\"https://doi.org/10.7554/eLife.78995\">10.7554/eLife.78995</a>","mla":"Tomasek, Kathrin, et al. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack the Host Immune Response by Binding to CD14.” <i>ELife</i>, vol. 11, e78995, eLife Sciences Publications, 2022, doi:<a href=\"https://doi.org/10.7554/eLife.78995\">10.7554/eLife.78995</a>.","chicago":"Tomasek, Kathrin, Alexander F Leithner, Ivana Glatzová, Michael S. Lukesch, Calin C Guet, and Michael K Sixt. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack the Host Immune Response by Binding to CD14.” <i>ELife</i>. eLife Sciences Publications, 2022. <a href=\"https://doi.org/10.7554/eLife.78995\">https://doi.org/10.7554/eLife.78995</a>."},"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2022","date_created":"2022-08-14T22:01:46Z","ddc":["570"],"project":[{"name":"Cellular Navigation Along Spatial Gradients","call_identifier":"H2020","grant_number":"724373","_id":"25FE9508-B435-11E9-9278-68D0E5697425"},{"_id":"26018E70-B435-11E9-9278-68D0E5697425","grant_number":"P29911","call_identifier":"FWF","name":"Mechanical adaptation of lamellipodial actin"}],"date_published":"2022-07-26T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":11,"date_updated":"2026-07-06T12:48:19Z","publication_status":"published","external_id":{"pmid":["35881547"],"isi":["000838410200001"]},"department":[{"_id":"MiSi"},{"_id":"CaGu"}],"abstract":[{"text":"A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish persistent infections. However, the molecular mechanisms and strategies by which bacteria actively circumvent the immune response of the host remain poorly understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli. The FimH amino acids involved in CD14 binding are highly conserved across pathogenic and non-pathogenic strains. Binding of the pathogenic strain CFT073 to CD14 reduced DC migration by overactivation of integrins and blunted expression of co-stimulatory molecules by overactivating the NFAT (nuclear factor of activated T-cells) pathway, both rate-limiting factors of T cell activation. This response was binary at the single-cell level, but averaged in larger populations exposed to both piliated and non-piliated pathogens, presumably via the exchange of immunomodulatory cytokines. While defining an active molecular mechanism of immune evasion by pathogens, the interaction between FimH and CD14 represents a potential target to interfere with persistent and recurrent infections, such as urinary tract infections or Crohn’s disease.","lang":"eng"}],"ec_funded":1,"doi":"10.7554/eLife.78995","file_date_updated":"2022-08-16T08:57:37Z","publication":"eLife","file":[{"content_type":"application/pdf","success":1,"date_created":"2022-08-16T08:57:37Z","relation":"main_file","file_id":"11861","checksum":"002a3c7c7ea5caa9af9cfbea308f6ea4","date_updated":"2022-08-16T08:57:37Z","file_size":2057577,"file_name":"2022_eLife_Tomasek.pdf","access_level":"open_access","creator":"cchlebak"}],"intvolume":"        11"}]