[{"article_processing_charge":"No","date_updated":"2023-08-24T14:48:59Z","publication":"Proceedings of the American Mathematical Society","type":"journal_article","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/1709.02562","open_access":"1"}],"publication_status":"published","doi":"10.1090/proc/14240","volume":147,"title":"Two circles and only a straightedge","year":"2019","day":"01","oa":1,"abstract":[{"text":"We answer a question of David Hilbert: given two circles it is not possible in general to construct their centers using only a straightedge. On the other hand, we give infinitely many families of pairs of circles for which such construction is possible. ","lang":"eng"}],"language":[{"iso":"eng"}],"citation":{"ieee":"A. Akopyan and R. Fedorov, “Two circles and only a straightedge,” <i>Proceedings of the American Mathematical Society</i>, vol. 147. AMS, pp. 91–102, 2019.","ama":"Akopyan A, Fedorov R. Two circles and only a straightedge. <i>Proceedings of the American Mathematical Society</i>. 2019;147:91-102. doi:<a href=\"https://doi.org/10.1090/proc/14240\">10.1090/proc/14240</a>","apa":"Akopyan, A., &#38; Fedorov, R. (2019). Two circles and only a straightedge. <i>Proceedings of the American Mathematical Society</i>. AMS. <a href=\"https://doi.org/10.1090/proc/14240\">https://doi.org/10.1090/proc/14240</a>","ista":"Akopyan A, Fedorov R. 2019. Two circles and only a straightedge. Proceedings of the American Mathematical Society. 147, 91–102.","mla":"Akopyan, Arseniy, and Roman Fedorov. “Two Circles and Only a Straightedge.” <i>Proceedings of the American Mathematical Society</i>, vol. 147, AMS, 2019, pp. 91–102, doi:<a href=\"https://doi.org/10.1090/proc/14240\">10.1090/proc/14240</a>.","short":"A. Akopyan, R. Fedorov, Proceedings of the American Mathematical Society 147 (2019) 91–102.","chicago":"Akopyan, Arseniy, and Roman Fedorov. “Two Circles and Only a Straightedge.” <i>Proceedings of the American Mathematical Society</i>. AMS, 2019. <a href=\"https://doi.org/10.1090/proc/14240\">https://doi.org/10.1090/proc/14240</a>."},"publisher":"AMS","department":[{"_id":"HeEd"}],"date_created":"2019-02-24T22:59:19Z","page":"91-102","status":"public","month":"01","date_published":"2019-01-01T00:00:00Z","quality_controlled":"1","intvolume":"       147","_id":"6050","author":[{"last_name":"Akopyan","first_name":"Arseniy","orcid":"0000-0002-2548-617X","full_name":"Akopyan, Arseniy","id":"430D2C90-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fedorov","first_name":"Roman","full_name":"Fedorov, Roman"}],"external_id":{"isi":["000450363900008"],"arxiv":["1709.02562"]},"arxiv":1,"isi":1,"oa_version":"Preprint","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"ddc":["570"],"scopus_import":"1","date_updated":"2025-04-14T07:44:00Z","type":"journal_article","publication":"Nature Protocols","article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"abstract":[{"text":"Expansion microscopy is a relatively new approach to super-resolution imaging that uses expandable hydrogels to isotropically increase the physical distance between fluorophores in biological samples such as cell cultures or tissue slices. The classic gel recipe results in an expansion factor of ~4×, with a resolution of 60–80 nm. We have recently developed X10 microscopy, which uses a gel that achieves an expansion factor of ~10×, with a resolution of ~25 nm. Here, we provide a step-by-step protocol for X10 expansion microscopy. A typical experiment consists of seven sequential stages: (i) immunostaining, (ii) anchoring, (iii) polymerization, (iv) homogenization, (v) expansion, (vi) imaging, and (vii) validation. The protocol presented here includes recommendations for optimization, pitfalls and their solutions, and detailed guidelines that should increase reproducibility. Although our protocol focuses on X10 expansion microscopy, we detail which of these suggestions are also applicable to classic fourfold expansion microscopy. We exemplify our protocol using primary hippocampal neurons from rats, but our approach can be used with other primary cells or cultured cell lines of interest. This protocol will enable any researcher with basic experience in immunostainings and access to an epifluorescence microscope to perform super-resolution microscopy with X10. The procedure takes 3 d and requires ~5 h of actively handling the sample for labeling and expansion, and another ~3 h for imaging and analysis.","lang":"eng"}],"day":"01","oa":1,"title":"A practical guide to optimization in X10 expansion microscopy","volume":14,"year":"2019","doi":"10.1038/s41596-018-0117-3","publication_status":"published","file_date_updated":"2021-06-29T14:41:46Z","ec_funded":1,"issue":"3","intvolume":"        14","_id":"6052","project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"},{"grant_number":"I03600","name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"quality_controlled":"1","date_published":"2019-03-01T00:00:00Z","status":"public","month":"03","page":"832–863","department":[{"_id":"JoDa"},{"_id":"Bio"}],"date_created":"2019-02-24T22:59:20Z","citation":{"ieee":"S. M. Truckenbrodt, C. M. Sommer, S. O. Rizzoli, and J. G. Danzl, “A practical guide to optimization in X10 expansion microscopy,” <i>Nature Protocols</i>, vol. 14, no. 3. Nature Publishing Group, pp. 832–863, 2019.","ama":"Truckenbrodt SM, Sommer CM, Rizzoli SO, Danzl JG. A practical guide to optimization in X10 expansion microscopy. <i>Nature Protocols</i>. 2019;14(3):832–863. doi:<a href=\"https://doi.org/10.1038/s41596-018-0117-3\">10.1038/s41596-018-0117-3</a>","apa":"Truckenbrodt, S. M., Sommer, C. M., Rizzoli, S. O., &#38; Danzl, J. G. (2019). A practical guide to optimization in X10 expansion microscopy. <i>Nature Protocols</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41596-018-0117-3\">https://doi.org/10.1038/s41596-018-0117-3</a>","chicago":"Truckenbrodt, Sven M, Christoph M Sommer, Silvio O Rizzoli, and Johann G Danzl. “A Practical Guide to Optimization in X10 Expansion Microscopy.” <i>Nature Protocols</i>. Nature Publishing Group, 2019. <a href=\"https://doi.org/10.1038/s41596-018-0117-3\">https://doi.org/10.1038/s41596-018-0117-3</a>.","ista":"Truckenbrodt SM, Sommer CM, Rizzoli SO, Danzl JG. 2019. A practical guide to optimization in X10 expansion microscopy. Nature Protocols. 14(3), 832–863.","mla":"Truckenbrodt, Sven M., et al. “A Practical Guide to Optimization in X10 Expansion Microscopy.” <i>Nature Protocols</i>, vol. 14, no. 3, Nature Publishing Group, 2019, pp. 832–863, doi:<a href=\"https://doi.org/10.1038/s41596-018-0117-3\">10.1038/s41596-018-0117-3</a>.","short":"S.M. Truckenbrodt, C.M. Sommer, S.O. Rizzoli, J.G. Danzl, Nature Protocols 14 (2019) 832–863."},"publisher":"Nature Publishing Group","has_accepted_license":"1","file":[{"file_name":"181031_Truckenbrodt_ExM_NatProtoc.docx","checksum":"7efb9951e7ddf3e3dcc2fb92b859c623","success":1,"file_size":84478958,"access_level":"open_access","relation":"main_file","date_created":"2021-06-29T14:41:46Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"kschuh","date_updated":"2021-06-29T14:41:46Z","file_id":"9619"}],"oa_version":"Submitted Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"pmid":1,"author":[{"id":"45812BD4-F248-11E8-B48F-1D18A9856A87","full_name":"Truckenbrodt, Sven M","last_name":"Truckenbrodt","first_name":"Sven M"},{"first_name":"Christoph M","last_name":"Sommer","full_name":"Sommer, Christoph M","orcid":"0000-0003-1216-9105","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Silvio O","last_name":"Rizzoli","full_name":"Rizzoli, Silvio O"},{"id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","last_name":"Danzl","first_name":"Johann G"}],"external_id":{"pmid":["30778205"],"isi":["000459890700008"]}},{"article_processing_charge":"No","article_type":"original","type":"journal_article","publication":"Nature Nanotechnology","date_updated":"2023-08-24T14:48:08Z","scopus_import":"1","main_file_link":[{"url":"https://authors.library.caltech.edu/92123/","open_access":"1"}],"doi":"10.1038/s41565-019-0377-2","publication_status":"published","oa":1,"day":"01","year":"2019","volume":14,"title":"Quantum electromechanics of a hypersonic crystal","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Recent technical developments in the fields of quantum electromechanics and optomechanics have spawned nanoscale mechanical transducers with the sensitivity to measure mechanical displacements at the femtometre scale and the ability to convert electromagnetic signals at the single photon level. A key challenge in this field is obtaining strong coupling between motion and electromagnetic fields without adding additional decoherence. Here we present an electromechanical transducer that integrates a high-frequency (0.42 GHz) hypersonic phononic crystal with a superconducting microwave circuit. The use of a phononic bandgap crystal enables quantum-level transduction of hypersonic mechanical motion and concurrently eliminates decoherence caused by acoustic radiation. Devices with hypersonic mechanical frequencies provide a natural pathway for integration with Josephson junction quantum circuits, a leading quantum computing technology, and nanophotonic systems capable of optical networking and distributing quantum information."}],"department":[{"_id":"JoFi"}],"date_created":"2019-02-24T22:59:21Z","publisher":"Springer Nature","citation":{"chicago":"Kalaee, Mahmoud, Mohammad Mirhosseini, Paul B. Dieterle, Matilda Peruzzo, Johannes M Fink, and Oskar Painter. “Quantum Electromechanics of a Hypersonic Crystal.” <i>Nature Nanotechnology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41565-019-0377-2\">https://doi.org/10.1038/s41565-019-0377-2</a>.","ista":"Kalaee M, Mirhosseini M, Dieterle PB, Peruzzo M, Fink JM, Painter O. 2019. Quantum electromechanics of a hypersonic crystal. Nature Nanotechnology. 14(4), 334–339.","mla":"Kalaee, Mahmoud, et al. “Quantum Electromechanics of a Hypersonic Crystal.” <i>Nature Nanotechnology</i>, vol. 14, no. 4, Springer Nature, 2019, pp. 334–339, doi:<a href=\"https://doi.org/10.1038/s41565-019-0377-2\">10.1038/s41565-019-0377-2</a>.","short":"M. Kalaee, M. Mirhosseini, P.B. Dieterle, M. Peruzzo, J.M. Fink, O. Painter, Nature Nanotechnology 14 (2019) 334–339.","ieee":"M. Kalaee, M. Mirhosseini, P. B. Dieterle, M. Peruzzo, J. M. Fink, and O. Painter, “Quantum electromechanics of a hypersonic crystal,” <i>Nature Nanotechnology</i>, vol. 14, no. 4. Springer Nature, pp. 334–339, 2019.","apa":"Kalaee, M., Mirhosseini, M., Dieterle, P. B., Peruzzo, M., Fink, J. M., &#38; Painter, O. (2019). Quantum electromechanics of a hypersonic crystal. <i>Nature Nanotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41565-019-0377-2\">https://doi.org/10.1038/s41565-019-0377-2</a>","ama":"Kalaee M, Mirhosseini M, Dieterle PB, Peruzzo M, Fink JM, Painter O. Quantum electromechanics of a hypersonic crystal. <i>Nature Nanotechnology</i>. 2019;14(4):334–339. doi:<a href=\"https://doi.org/10.1038/s41565-019-0377-2\">10.1038/s41565-019-0377-2</a>"},"month":"04","status":"public","page":"334–339","quality_controlled":"1","date_published":"2019-04-01T00:00:00Z","_id":"6053","issue":"4","publication_identifier":{"eissn":["1748-3395"],"issn":["1748-3387"]},"intvolume":"        14","isi":1,"external_id":{"isi":["000463195700014"]},"author":[{"first_name":"Mahmoud","last_name":"Kalaee","full_name":"Kalaee, Mahmoud"},{"last_name":"Mirhosseini","first_name":"Mohammad","full_name":"Mirhosseini, Mohammad"},{"full_name":"Dieterle, Paul B.","last_name":"Dieterle","first_name":"Paul B."},{"last_name":"Peruzzo","first_name":"Matilda","id":"3F920B30-F248-11E8-B48F-1D18A9856A87","full_name":"Peruzzo, Matilda","orcid":"0000-0002-3415-4628"},{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","first_name":"Johannes M","last_name":"Fink"},{"full_name":"Painter, Oskar","first_name":"Oskar","last_name":"Painter"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Submitted Version"},{"article_processing_charge":"No","month":"02","status":"public","publisher":"Institute of Science and Technology Austria","citation":{"ieee":"B. Vicoso, “Supplementary data for ‘Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome’ (Huylman, Toups et al., 2019). .” Institute of Science and Technology Austria, 2019.","ama":"Vicoso B. Supplementary data for “Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome” (Huylman, Toups et al., 2019). . 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6060\">10.15479/AT:ISTA:6060</a>","apa":"Vicoso, B. (2019). Supplementary data for “Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome” (Huylman, Toups et al., 2019). . Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:6060\">https://doi.org/10.15479/AT:ISTA:6060</a>","chicago":"Vicoso, Beatriz. “Supplementary Data for ‘Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome’ (Huylman, Toups et Al., 2019). .” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:6060\">https://doi.org/10.15479/AT:ISTA:6060</a>.","ista":"Vicoso B. 2019. Supplementary data for ‘Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome’ (Huylman, Toups et al., 2019). , Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:6060\">10.15479/AT:ISTA:6060</a>.","short":"B. Vicoso, (2019).","mla":"Vicoso, Beatriz. <i>Supplementary Data for “Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome” (Huylman, Toups et Al., 2019). </i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6060\">10.15479/AT:ISTA:6060</a>."},"department":[{"_id":"BeVi"}],"date_created":"2019-02-28T10:55:15Z","_id":"6060","date_published":"2019-02-28T00:00:00Z","type":"research_data","date_updated":"2025-04-15T07:49:47Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.15479/AT:ISTA:6060","related_material":{"record":[{"status":"public","id":"6418","relation":"research_paper"}]},"oa_version":"Published Version","author":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","last_name":"Vicoso","first_name":"Beatriz"}],"file_date_updated":"2020-07-14T12:47:17Z","file":[{"content_type":"application/zip","creator":"bvicoso","date_updated":"2020-07-14T12:47:17Z","file_id":"6061","file_name":"SupData.zip","checksum":"a338a622d728af0e3199cb07e6dd64d3","file_size":36646050,"access_level":"open_access","relation":"main_file","date_created":"2019-02-28T10:54:27Z"}],"has_accepted_license":"1","year":"2019","title":"Supplementary data for \"Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome\" (Huylman, Toups et al., 2019). ","oa":1,"day":"28"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.15479/AT:ISTA:6062","oa_version":"Published Version","related_material":{"record":[{"id":"6194","status":"public","relation":"research_paper"}]},"file_date_updated":"2020-07-14T12:47:18Z","author":[{"id":"30BD0376-F248-11E8-B48F-1D18A9856A87","full_name":"Nardin, Michele","orcid":"0000-0001-8849-6570","last_name":"Nardin","first_name":"Michele"}],"abstract":[{"text":"Open the files in Jupyter Notebook (reccomended https://www.anaconda.com/distribution/#download-section with Python 3.7).","lang":"eng"}],"file":[{"checksum":"48e7b9a02939b763417733239522a236","file_size":37002186,"file_name":"Online_data.zip","date_created":"2019-03-05T09:29:37Z","relation":"main_file","access_level":"open_access","creator":"mnardin","content_type":"application/zip","date_updated":"2020-07-14T12:47:18Z","file_id":"6068","title":"Data for the paper \"The Entorhinal Cognitive Map is Attracted to Goals\""}],"has_accepted_license":"1","oa":1,"day":"29","year":"2019","title":"Supplementary Code and Data for the paper \"The Entorhinal Cognitive Map is Attracted to Goals\"","article_processing_charge":"No","month":"03","status":"public","tmp":{"image":"/images/cc_by_sa.png","short":"CC BY-SA (4.0)","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode"},"date_created":"2019-03-04T14:20:58Z","department":[{"_id":"JoCs"}],"publisher":"Institute of Science and Technology Austria","citation":{"ama":"Nardin M. Supplementary Code and Data for the paper “The Entorhinal Cognitive Map is Attracted to Goals.” 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6062\">10.15479/AT:ISTA:6062</a>","apa":"Nardin, M. (2019). Supplementary Code and Data for the paper “The Entorhinal Cognitive Map is Attracted to Goals.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:6062\">https://doi.org/10.15479/AT:ISTA:6062</a>","ieee":"M. Nardin, “Supplementary Code and Data for the paper ‘The Entorhinal Cognitive Map is Attracted to Goals.’” Institute of Science and Technology Austria, 2019.","chicago":"Nardin, Michele. “Supplementary Code and Data for the Paper ‘The Entorhinal Cognitive Map Is Attracted to Goals.’” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:6062\">https://doi.org/10.15479/AT:ISTA:6062</a>.","ista":"Nardin M. 2019. Supplementary Code and Data for the paper ‘The Entorhinal Cognitive Map is Attracted to Goals’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:6062\">10.15479/AT:ISTA:6062</a>.","short":"M. Nardin, (2019).","mla":"Nardin, Michele. <i>Supplementary Code and Data for the Paper “The Entorhinal Cognitive Map Is Attracted to Goals.”</i> Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6062\">10.15479/AT:ISTA:6062</a>."},"_id":"6062","type":"research_data","date_updated":"2025-04-15T07:21:17Z","date_published":"2019-03-29T00:00:00Z"},{"author":[{"last_name":"Mayzel","first_name":"Jonathan","full_name":"Mayzel, Jonathan"},{"last_name":"Steinberg","first_name":"Victor","full_name":"Steinberg, Victor"},{"full_name":"Varshney, Atul","orcid":"0000-0002-3072-5999","id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","last_name":"Varshney","first_name":"Atul"}],"external_id":{"isi":["000459704600001"]},"isi":1,"oa_version":"Published Version","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","file":[{"file_size":2646391,"checksum":"61192fc49e0d44907c2a4fe384e4b97f","file_name":"2019_NatureComm_Mayzel.pdf","relation":"main_file","access_level":"open_access","date_created":"2019-03-05T13:33:04Z","content_type":"application/pdf","creator":"dernst","file_id":"6070","date_updated":"2020-07-14T12:47:18Z"}],"publisher":"Springer Nature","citation":{"apa":"Mayzel, J., Steinberg, V., &#38; Varshney, A. (2019). Stokes flow analogous to viscous electron current in graphene. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-08916-5\">https://doi.org/10.1038/s41467-019-08916-5</a>","ieee":"J. Mayzel, V. Steinberg, and A. Varshney, “Stokes flow analogous to viscous electron current in graphene,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ama":"Mayzel J, Steinberg V, Varshney A. Stokes flow analogous to viscous electron current in graphene. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-08916-5\">10.1038/s41467-019-08916-5</a>","mla":"Mayzel, Jonathan, et al. “Stokes Flow Analogous to Viscous Electron Current in Graphene.” <i>Nature Communications</i>, vol. 10, 937, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-08916-5\">10.1038/s41467-019-08916-5</a>.","short":"J. Mayzel, V. Steinberg, A. Varshney, Nature Communications 10 (2019).","ista":"Mayzel J, Steinberg V, Varshney A. 2019. Stokes flow analogous to viscous electron current in graphene. Nature Communications. 10, 937.","chicago":"Mayzel, Jonathan, Victor Steinberg, and Atul Varshney. “Stokes Flow Analogous to Viscous Electron Current in Graphene.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-08916-5\">https://doi.org/10.1038/s41467-019-08916-5</a>."},"date_created":"2019-03-05T13:18:30Z","department":[{"_id":"BjHo"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"02","date_published":"2019-02-26T00:00:00Z","quality_controlled":"1","project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"intvolume":"        10","publication_identifier":{"issn":["2041-1723"]},"_id":"6069","ec_funded":1,"file_date_updated":"2020-07-14T12:47:18Z","publication_status":"published","doi":"10.1038/s41467-019-08916-5","volume":10,"title":"Stokes flow analogous to viscous electron current in graphene","year":"2019","day":"26","oa":1,"corr_author":"1","abstract":[{"lang":"eng","text":"Electron transport in two-dimensional conducting materials such as graphene, with dominant electron–electron interaction, exhibits unusual vortex flow that leads to a nonlocal current-field relation (negative resistance), distinct from the classical Ohm’s law. The transport behavior of these materials is best described by low Reynolds number hydrodynamics, where the constitutive pressure–speed relation is Stoke’s law. Here we report evidence of such vortices observed in a viscous flow of Newtonian fluid in a microfluidic device consisting of a rectangular cavity—analogous to the electronic system. We extend our experimental observations to elliptic cavities of different eccentricities, and validate them by numerically solving bi-harmonic equation obtained for the viscous flow with no-slip boundary conditions. We verify the existence of a  predicted threshold at which vortices appear. Strikingly, we find that a two-dimensional theoretical model captures the essential features of three-dimensional Stokes flow in experiments."}],"language":[{"iso":"eng"}],"article_number":"937","article_processing_charge":"No","date_updated":"2025-04-14T07:44:00Z","publication":"Nature Communications","type":"journal_article","ddc":["530","532"],"scopus_import":"1"},{"related_material":{"record":[{"relation":"research_paper","id":"3","status":"public"}]},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.15479/AT:ISTA:6074","author":[{"full_name":"Dotter, Christoph","id":"4C66542E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9033-9096","last_name":"Dotter","first_name":"Christoph"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia"}],"file_date_updated":"2020-07-14T12:47:18Z","has_accepted_license":"1","file":[{"creator":"dernst","content_type":"application/zip","file_id":"6084","date_updated":"2020-07-14T12:47:18Z","checksum":"bc1b285edca9e98a2c63d153c79bb75b","file_size":33202743,"file_name":"Setd5_paper.zip","date_created":"2019-03-07T13:37:19Z","relation":"supplementary_material","access_level":"open_access"}],"abstract":[{"lang":"eng","text":"This dataset contains the supplementary data for the research paper \"Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition\".\r\n\r\nThe contained files have the following content:\r\n'Supplementary Figures.pdf'\r\n\tAdditional figures (as referenced in the paper).\r\n'Supplementary Table 1. Statistics.xlsx'\r\n\tDetails on statistical tests performed in the paper.\r\n'Supplementary Table 2. Differentially expressed gene analysis.xlsx'\r\n\tResults for the differential gene expression analysis for embryonic (E9.5; analysis with edgeR) and in vitro (ESCs, EBs, NPCs; analysis with DESeq2) samples.\r\n'Supplementary Table 3. Gene Ontology (GO) term enrichment analysis.xlsx'\r\n\tResults for the GO term enrichment analysis for differentially expressed genes in embryonic (GO E9.5) and in vitro (GO ESC, GO EBs, GO NPCs) samples. Differentially expressed genes for in vitro samples were split into upregulated and downregulated genes (up/down) and the analysis was performed on each subset (e.g. GO ESC up / GO ESC down).\r\n'Supplementary Table 4. Differentially expressed gene analysis for CFC samples.xlsx'\r\n\tResults for the differential gene expression analysis for samples from adult mice before (HC - Homecage) and 1h and 3h after contextual fear conditioning (1h and 3h, respectively). Each sheet shows the results for a different comparison. Sheets 1-3 show results for comparisons between timepoints for wild type (WT) samples only and sheets 4-6 for the same comparisons in mutant (Het) samples. Sheets 7-9 show results for comparisons between genotypes at each time point and sheet 10 contains the results for the analysis of differential expression trajectories between wild type and mutant.\r\n'Supplementary Table 5. Cluster identification.xlsx'\r\n\tResults for k-means clustering of genes by expression. Sheet 1 shows clustering of just the genes with significantly different expression trajectories between genotypes. Sheet 2 shows clustering of all genes that are significantly differentially expressed in any of the comparisons (includes also genes with same trajectories).\r\n'Supplementary Table 6. GO term cluster analysis.xlsx'\r\n\tResults for the GO term enrichment analysis and EWCE analysis for enrichment of cell type specific genes for each cluster identified by clustering genes with different expression trajectories (see Table S5, sheet 1).\r\n'Supplementary Table 7. Setd5 mass spectrometry results.xlsx'\r\n\tResults showing proteins interacting with Setd5 as identified by mass spectrometry. Sheet 1 shows protein protein interaction data generated from these results (combined with data from the STRING database. Sheet 2 shows the results of the statistical analysis with limma.\r\n'Supplementary Table 8. PolII ChIP-seq analysis.xlsx'\r\n\tResults for the Chip-Seq analysis for binding of RNA polymerase II (PolII). Sheet 1 shows results for differential binding of PolII at the transcription start site (TSS) between genotypes and sheets 2+3 show the corresponding GO enrichment analysis for these differentially bound genes. Sheet 4 shows RNAseq counts for genes with increased binding of PolII at the TSS."}],"title":"Supplementary data for the research paper \"Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition\"","year":"2019","day":"09","oa":1,"status":"public","article_processing_charge":"No","month":"01","publisher":"Institute of Science and Technology Austria","citation":{"ieee":"C. Dotter and G. Novarino, “Supplementary data for the research paper ‘Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.’” Institute of Science and Technology Austria, 2019.","ama":"Dotter C, Novarino G. Supplementary data for the research paper “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.” 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6074\">10.15479/AT:ISTA:6074</a>","apa":"Dotter, C., &#38; Novarino, G. (2019). Supplementary data for the research paper “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:6074\">https://doi.org/10.15479/AT:ISTA:6074</a>","chicago":"Dotter, Christoph, and Gaia Novarino. “Supplementary Data for the Research Paper ‘Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.’” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:6074\">https://doi.org/10.15479/AT:ISTA:6074</a>.","mla":"Dotter, Christoph, and Gaia Novarino. <i>Supplementary Data for the Research Paper “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.”</i> Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:6074\">10.15479/AT:ISTA:6074</a>.","short":"C. Dotter, G. Novarino, (2019).","ista":"Dotter C, Novarino G. 2019. Supplementary data for the research paper ‘Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:6074\">10.15479/AT:ISTA:6074</a>."},"date_created":"2019-03-07T13:32:35Z","department":[{"_id":"GaNo"}],"ddc":["570"],"_id":"6074","date_published":"2019-01-09T00:00:00Z","date_updated":"2025-04-15T07:50:27Z","type":"research_data"},{"title":"Singular analytic linear cocycles with negative infinite Lyapunov exponents","volume":39,"year":"2019","day":"01","oa":1,"abstract":[{"lang":"eng","text":"We show that linear analytic cocycles where all Lyapunov exponents are negative infinite are nilpotent. For such one-frequency cocycles we show that they can be analytically conjugated to an upper triangular cocycle or a Jordan normal form. As a consequence, an arbitrarily small analytic perturbation leads to distinct Lyapunov exponents. Moreover, in the one-frequency case where the th Lyapunov exponent is finite and the st negative infinite, we obtain a simple criterion for domination in which case there is a splitting into a nilpotent part and an invertible part."}],"language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1601.06118"}],"ec_funded":1,"publication_status":"published","doi":"10.1017/etds.2017.52","date_updated":"2025-04-15T06:50:24Z","type":"journal_article","publication":"Ergodic Theory and Dynamical Systems","scopus_import":"1","article_processing_charge":"No","author":[{"full_name":"Sadel, Christian","id":"4760E9F8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8255-3968","first_name":"Christian","last_name":"Sadel"},{"full_name":"Xu, Disheng","last_name":"Xu","first_name":"Disheng"}],"arxiv":1,"external_id":{"isi":["000459725600012"],"arxiv":["1601.06118"]},"isi":1,"oa_version":"Preprint","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2019-04-01T00:00:00Z","quality_controlled":"1","project":[{"grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"intvolume":"        39","issue":"4","_id":"6086","citation":{"ieee":"C. Sadel and D. Xu, “Singular analytic linear cocycles with negative infinite Lyapunov exponents,” <i>Ergodic Theory and Dynamical Systems</i>, vol. 39, no. 4. Cambridge University Press, pp. 1082–1098, 2019.","ama":"Sadel C, Xu D. Singular analytic linear cocycles with negative infinite Lyapunov exponents. <i>Ergodic Theory and Dynamical Systems</i>. 2019;39(4):1082-1098. doi:<a href=\"https://doi.org/10.1017/etds.2017.52\">10.1017/etds.2017.52</a>","apa":"Sadel, C., &#38; Xu, D. (2019). Singular analytic linear cocycles with negative infinite Lyapunov exponents. <i>Ergodic Theory and Dynamical Systems</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/etds.2017.52\">https://doi.org/10.1017/etds.2017.52</a>","chicago":"Sadel, Christian, and Disheng Xu. “Singular Analytic Linear Cocycles with Negative Infinite Lyapunov Exponents.” <i>Ergodic Theory and Dynamical Systems</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/etds.2017.52\">https://doi.org/10.1017/etds.2017.52</a>.","ista":"Sadel C, Xu D. 2019. Singular analytic linear cocycles with negative infinite Lyapunov exponents. Ergodic Theory and Dynamical Systems. 39(4), 1082–1098.","short":"C. Sadel, D. Xu, Ergodic Theory and Dynamical Systems 39 (2019) 1082–1098.","mla":"Sadel, Christian, and Disheng Xu. “Singular Analytic Linear Cocycles with Negative Infinite Lyapunov Exponents.” <i>Ergodic Theory and Dynamical Systems</i>, vol. 39, no. 4, Cambridge University Press, 2019, pp. 1082–98, doi:<a href=\"https://doi.org/10.1017/etds.2017.52\">10.1017/etds.2017.52</a>."},"publisher":"Cambridge University Press","date_created":"2019-03-10T22:59:18Z","department":[{"_id":"LaEr"}],"page":"1082-1098","status":"public","month":"04"},{"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"abstract":[{"text":"Cell fate specification by lateral inhibition typically involves contact signaling through the Delta-Notch signaling pathway. However, whether this is the only signaling mode mediating lateral inhibition remains unclear. Here we show that in zebrafish oogenesis, a group of cells within the granulosa cell layer at the oocyte animal pole acquire elevated levels of the transcriptional coactivator TAZ in their nuclei. One of these cells, the future micropyle precursor cell (MPC), accumulates increasingly high levels of nuclear TAZ and grows faster than its surrounding cells, mechanically compressing those cells, which ultimately lose TAZ from their nuclei. Strikingly, relieving neighbor-cell compression by MPC ablation or aspiration restores nuclear TAZ accumulation in neighboring cells, eventually leading to MPC re-specification from these cells. Conversely, MPC specification is defective in taz−/− follicles. These findings uncover a novel mode of lateral inhibition in cell fate specification based on mechanical signals controlling TAZ activity.","lang":"eng"}],"language":[{"iso":"eng"}],"volume":176,"title":"Lateral inhibition in cell specification mediated by mechanical signals modulating TAZ activity","year":"2019","day":"07","oa":1,"publication_status":"published","doi":"10.1016/j.cell.2019.01.019","ec_funded":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2019.01.019","open_access":"1"}],"scopus_import":"1","date_updated":"2025-04-14T07:46:59Z","type":"journal_article","publication":"Cell","article_type":"original","article_processing_charge":"No","acknowledgement":"We thank Roland Dosch, Makoto Furutani-Seiki, Brian Link, Mary Mullins, and Masazumi Tada for providing transgenic and/or mutant zebrafish lines; Alexandra Schauer, Shayan Shami-Pour, and the rest of the Heisenberg lab for technical assistance and feedback on the manuscript; and the Bioimaging, Electron Microscopy, and Zebrafish facilities of IST Austria for continuous support. This work was supported by an ERC advanced grant ( MECSPEC to C.-P.H.).","oa_version":"Published Version","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/in-zebrafish-eggs-most-rapidly-growing-cell-inhibits-its-neighbours-through-mechanical-signals/"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"id":"4AB6C7D0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5419-7756","full_name":"Xia, Peng","last_name":"Xia","first_name":"Peng"},{"last_name":"Gütl","first_name":"Daniel J","full_name":"Gütl, Daniel J","id":"381929CE-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-9438-4783","id":"39C5A68A-F248-11E8-B48F-1D18A9856A87","full_name":"Zheden, Vanessa","first_name":"Vanessa","last_name":"Zheden"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"pmid":1,"external_id":{"pmid":["30773315"],"isi":["000460509600013"]},"isi":1,"intvolume":"       176","issue":"6","_id":"6087","date_published":"2019-03-07T00:00:00Z","project":[{"grant_number":"742573","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"quality_controlled":"1","page":"1379-1392.e14","status":"public","month":"03","publisher":"Elsevier","citation":{"chicago":"Xia, Peng, Daniel J Gütl, Vanessa Zheden, and Carl-Philipp J Heisenberg. “Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity.” <i>Cell</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cell.2019.01.019\">https://doi.org/10.1016/j.cell.2019.01.019</a>.","mla":"Xia, Peng, et al. “Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity.” <i>Cell</i>, vol. 176, no. 6, Elsevier, 2019, p. 1379–1392.e14, doi:<a href=\"https://doi.org/10.1016/j.cell.2019.01.019\">10.1016/j.cell.2019.01.019</a>.","short":"P. Xia, D.J. Gütl, V. Zheden, C.-P.J. Heisenberg, Cell 176 (2019) 1379–1392.e14.","ista":"Xia P, Gütl DJ, Zheden V, Heisenberg C-PJ. 2019. Lateral inhibition in cell specification mediated by mechanical signals modulating TAZ activity. Cell. 176(6), 1379–1392.e14.","ama":"Xia P, Gütl DJ, Zheden V, Heisenberg C-PJ. Lateral inhibition in cell specification mediated by mechanical signals modulating TAZ activity. <i>Cell</i>. 2019;176(6):1379-1392.e14. doi:<a href=\"https://doi.org/10.1016/j.cell.2019.01.019\">10.1016/j.cell.2019.01.019</a>","ieee":"P. Xia, D. J. Gütl, V. Zheden, and C.-P. J. Heisenberg, “Lateral inhibition in cell specification mediated by mechanical signals modulating TAZ activity,” <i>Cell</i>, vol. 176, no. 6. Elsevier, p. 1379–1392.e14, 2019.","apa":"Xia, P., Gütl, D. J., Zheden, V., &#38; Heisenberg, C.-P. J. (2019). Lateral inhibition in cell specification mediated by mechanical signals modulating TAZ activity. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2019.01.019\">https://doi.org/10.1016/j.cell.2019.01.019</a>"},"date_created":"2019-03-10T22:59:19Z","department":[{"_id":"CaHe"},{"_id":"EM-Fac"}]},{"_id":"6088","issue":"3","intvolume":"        16","date_published":"2019-03-04T00:00:00Z","quality_controlled":"1","page":"1282-1293","month":"03","status":"public","publisher":"American Chemical Society","citation":{"apa":"Traxl, A., Mairinger, S., Filip, T., Sauberer, M., Stanek, J., Poschner, S., … Langer, O. (2019). Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Molecular Pharmaceutics</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.molpharmaceut.8b01217\">https://doi.org/10.1021/acs.molpharmaceut.8b01217</a>","ieee":"A. Traxl <i>et al.</i>, “Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib,” <i>Molecular Pharmaceutics</i>, vol. 16, no. 3. American Chemical Society, pp. 1282–1293, 2019.","ama":"Traxl A, Mairinger S, Filip T, et al. Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Molecular Pharmaceutics</i>. 2019;16(3):1282-1293. doi:<a href=\"https://doi.org/10.1021/acs.molpharmaceut.8b01217\">10.1021/acs.molpharmaceut.8b01217</a>","chicago":"Traxl, Alexander, Severin Mairinger, Thomas Filip, Michael Sauberer, Johann Stanek, Stefan Poschner, Walter Jäger, et al. “Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Molecular Pharmaceutics</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/acs.molpharmaceut.8b01217\">https://doi.org/10.1021/acs.molpharmaceut.8b01217</a>.","mla":"Traxl, Alexander, et al. “Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Molecular Pharmaceutics</i>, vol. 16, no. 3, American Chemical Society, 2019, pp. 1282–93, doi:<a href=\"https://doi.org/10.1021/acs.molpharmaceut.8b01217\">10.1021/acs.molpharmaceut.8b01217</a>.","short":"A. Traxl, S. Mairinger, T. Filip, M. Sauberer, J. Stanek, S. Poschner, W. Jäger, V. Zoufal, G. Novarino, N. Tournier, M. Bauer, T. Wanek, O. Langer, Molecular Pharmaceutics 16 (2019) 1282–1293.","ista":"Traxl A, Mairinger S, Filip T, Sauberer M, Stanek J, Poschner S, Jäger W, Zoufal V, Novarino G, Tournier N, Bauer M, Wanek T, Langer O. 2019. Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Molecular Pharmaceutics. 16(3), 1282–1293."},"date_created":"2019-03-10T22:59:19Z","department":[{"_id":"GaNo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"None","external_id":{"pmid":["30694684"],"isi":["000460600400031"]},"author":[{"full_name":"Traxl, Alexander","last_name":"Traxl","first_name":"Alexander"},{"first_name":"Severin","last_name":"Mairinger","full_name":"Mairinger, Severin"},{"last_name":"Filip","first_name":"Thomas","full_name":"Filip, Thomas"},{"first_name":"Michael","last_name":"Sauberer","full_name":"Sauberer, Michael"},{"first_name":"Johann","last_name":"Stanek","full_name":"Stanek, Johann"},{"full_name":"Poschner, Stefan","first_name":"Stefan","last_name":"Poschner"},{"full_name":"Jäger, Walter","first_name":"Walter","last_name":"Jäger"},{"last_name":"Zoufal","first_name":"Viktoria","full_name":"Zoufal, Viktoria"},{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"},{"full_name":"Tournier, Nicolas","first_name":"Nicolas","last_name":"Tournier"},{"full_name":"Bauer, Martin","last_name":"Bauer","first_name":"Martin"},{"first_name":"Thomas","last_name":"Wanek","full_name":"Wanek, Thomas"},{"full_name":"Langer, Oliver","first_name":"Oliver","last_name":"Langer"}],"pmid":1,"isi":1,"scopus_import":"1","publication":"Molecular Pharmaceutics","type":"journal_article","date_updated":"2023-08-25T08:02:51Z","article_processing_charge":"No","abstract":[{"text":"P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters at the blood–brain barrier (BBB), which effectively restrict brain distribution of diverse drugs, such as tyrosine kinase inhibitors. There is a crucial need for pharmacological ABCB1 and ABCG2 inhibition protocols for a more effective treatment of brain diseases. In the present study, seven marketed drugs (osimertinib, erlotinib, nilotinib, imatinib, lapatinib, pazopanib, and cyclosporine A) and one nonmarketed drug (tariquidar), with known in vitro ABCB1/ABCG2 inhibitory properties, were screened for their inhibitory potency at the BBB in vivo. Positron emission tomography (PET) using the model ABCB1/ABCG2 substrate [11C]erlotinib was performed in mice. Tested inhibitors were administered as i.v. bolus injections at 30 min before the start of the PET scan, followed by a continuous i.v. infusion for the duration of the PET scan. Five of the tested drugs increased total distribution volume of [11C]erlotinib in the brain (VT,brain) compared to vehicle-treated animals (tariquidar, + 69%; erlotinib, + 19% and +23% for the 21.5 mg/kg and the 43 mg/kg dose, respectively; imatinib, + 22%; lapatinib, + 25%; and cyclosporine A, + 49%). For all drugs, increases in [11C]erlotinib brain distribution were lower than in Abcb1a/b(−/−)Abcg2(−/−) mice (+149%), which suggested that only partial ABCB1/ABCG2 inhibition was reached at the mouse BBB. The plasma concentrations of the tested drugs at the time of the PET scan were higher than clinically achievable plasma concentrations. Some of the tested drugs led to significant increases in blood radioactivity concentrations measured at the end of the PET scan (erlotinib, + 103% and +113% for the 21.5 mg/kg and the 43 mg/kg dose, respectively; imatinib, + 125%; and cyclosporine A, + 101%), which was most likely caused by decreased hepatobiliary excretion of radioactivity. Taken together, our data suggest that some marketed tyrosine kinase inhibitors may be repurposed to inhibit ABCB1 and ABCG2 at the BBB. From a clinical perspective, moderate increases in brain delivery despite the administration of high i.v. doses as well as peripheral drug–drug interactions due to transporter inhibition in clearance organs question the translatability of this concept.","lang":"eng"}],"language":[{"iso":"eng"}],"year":"2019","title":"Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib","volume":16,"day":"04","publication_status":"published","doi":"10.1021/acs.molpharmaceut.8b01217"},{"page":"500-515","month":"03","status":"public","publisher":"Oxford University Press","citation":{"ama":"Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515. doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>","ieee":"C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>, vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.","apa":"Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>","mla":"Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36, no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>.","short":"C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36 (2019) 500–515.","ista":"Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. Molecular biology and evolution. 36(3), 500–515.","chicago":"Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>."},"date_created":"2019-03-10T22:59:19Z","department":[{"_id":"BeVi"},{"_id":"NiBa"}],"_id":"6089","publication_identifier":{"eissn":["1537-1719"],"issn":["0737-4038"]},"intvolume":"        36","issue":"3","date_published":"2019-03-01T00:00:00Z","quality_controlled":"1","project":[{"grant_number":"P28842-B22","call_identifier":"FWF","name":"Sex chromosome evolution under male- and female- heterogamety","_id":"250ED89C-B435-11E9-9278-68D0E5697425"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Submitted Version","related_material":{"record":[{"status":"public","id":"5757","relation":"popular_science"}]},"external_id":{"pmid":["30590559"],"isi":["000462585100006"]},"author":[{"first_name":"Christelle","last_name":"Fraisse","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","full_name":"Fraisse, Christelle","orcid":"0000-0001-8441-5075"},{"first_name":"Gemma","last_name":"Puixeu Sala","id":"33AB266C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8330-1754","full_name":"Puixeu Sala, Gemma"},{"full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","first_name":"Beatriz","last_name":"Vicoso"}],"pmid":1,"isi":1,"article_processing_charge":"No","scopus_import":"1","publication":"Molecular biology and evolution","type":"journal_article","date_updated":"2025-04-15T08:18:38Z","publication_status":"published","doi":"10.1093/molbev/msy246","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/30590559","open_access":"1"}],"abstract":[{"text":"Pleiotropy is the well-established idea that a single mutation affects multiple phenotypes. If a mutation has opposite effects on fitness when expressed in different contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce the efficacy of selection by limiting the fixation of beneficial mutations through adaptation, and the removal of deleterious mutations through purifying selection. Although this has been widely discussed, in particular in the context of a putative “gender load,” it has yet to be systematically quantified. In this work, we empirically estimate to which extent different pleiotropic regimes impede the efficacy of selection in Drosophila melanogaster. We use whole-genome polymorphism data from a single African population and divergence data from D. simulans to estimate the fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction of selection (DoS). After controlling for confounding covariates, we find that the different pleiotropic regimes have a relatively small, but significant, effect on selection efficacy. Specifically, our results suggest that pleiotropic sexual antagonism may restrict the efficacy of selection, but that this conflict can be resolved by limiting the expression of genes to the sex where they are beneficial. Intermediate levels of pleiotropy across tissues and life stages can also lead to maladaptation in D. melanogaster, due to inefficient purifying selection combined with low frequency of mutations that confer a selective advantage. Thus, our study highlights the need to consider the efficacy of selection in the context of antagonistic pleiotropy, and of genetic conflict in general.","lang":"eng"}],"language":[{"iso":"eng"}],"year":"2019","title":"Pleiotropy modulates the efficacy of selection in drosophila melanogaster","volume":36,"oa":1,"day":"01"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","external_id":{"isi":["000459916500007"]},"author":[{"last_name":"Carballo-Pacheco","first_name":"Martín","full_name":"Carballo-Pacheco, Martín"},{"full_name":"Desponds, Jonathan","first_name":"Jonathan","last_name":"Desponds"},{"first_name":"Tatyana","last_name":"Gavrilchenko","full_name":"Gavrilchenko, Tatyana"},{"full_name":"Mayer, Andreas","last_name":"Mayer","first_name":"Andreas"},{"full_name":"Prizak, Roshan","id":"4456104E-F248-11E8-B48F-1D18A9856A87","last_name":"Prizak","first_name":"Roshan"},{"full_name":"Reddy, Gautam","last_name":"Reddy","first_name":"Gautam"},{"full_name":"Nemenman, Ilya","last_name":"Nemenman","first_name":"Ilya"},{"full_name":"Mora, Thierry","first_name":"Thierry","last_name":"Mora"}],"isi":1,"month":"02","status":"public","citation":{"chicago":"Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>.","ista":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G, Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of multiple ligands. Physical Review E. 99(2), 022423.","short":"M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G. Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).","mla":"Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>, vol. 99, no. 2, 022423, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>.","ama":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. 2019;99(2). doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>","ieee":"M. Carballo-Pacheco <i>et al.</i>, “Receptor crosstalk improves concentration sensing of multiple ligands,” <i>Physical Review E</i>, vol. 99, no. 2. American Physical Society, 2019.","apa":"Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R., Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>"},"publisher":"American Physical Society","department":[{"_id":"NiBa"},{"_id":"GaTk"}],"date_created":"2019-03-10T22:59:20Z","_id":"6090","issue":"2","intvolume":"        99","date_published":"2019-02-26T00:00:00Z","quality_controlled":"1","publication_status":"published","doi":"10.1103/PhysRevE.99.022423","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/448118v1.abstract","open_access":"1"}],"abstract":[{"lang":"eng","text":"Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems, leading to crosstalk between ligand-receptor pairs. Crosstalk is often thought of as a deviation from optimal specific recognition, as the binding of noncognate ligands can interfere with the detection of the receptor's cognate ligand, possibly leading to a false triggering of a downstream signaling pathway. Here we quantify the optimal precision of sensing the concentrations of multiple ligands by a collection of promiscuous receptors. We demonstrate that crosstalk can improve precision in concentration sensing and discrimination tasks. To achieve superior precision, the additional information about ligand concentrations contained in short binding events of the noncognate ligand should be exploited. We present a proofreading scheme to realize an approximate estimation of multiple ligand concentrations that reaches a precision close to the derived optimal bounds. Our results help rationalize the observed ubiquity of receptor crosstalk in molecular sensing."}],"article_number":"022423","language":[{"iso":"eng"}],"year":"2019","volume":99,"title":"Receptor crosstalk improves concentration sensing of multiple ligands","oa":1,"day":"26","article_processing_charge":"No","scopus_import":"1","type":"journal_article","publication":"Physical Review E","date_updated":"2024-02-28T13:12:06Z"},{"file":[{"relation":"main_file","access_level":"open_access","date_created":"2019-03-11T16:15:37Z","checksum":"7b0800d003f14cd06b1802dea0c52941","file_size":7260753,"file_name":"2019_eLife_Henderson.pdf","file_id":"6098","date_updated":"2020-07-14T12:47:19Z","content_type":"application/pdf","creator":"dernst"}],"has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","isi":1,"external_id":{"isi":["000459380600001"],"pmid":["30789343"]},"pmid":1,"author":[{"first_name":"Nathan T.","last_name":"Henderson","full_name":"Henderson, Nathan T."},{"first_name":"Sylvain J.","last_name":"Le Marchand","full_name":"Le Marchand, Sylvain J."},{"full_name":"Hruska, Martin","first_name":"Martin","last_name":"Hruska"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon"},{"full_name":"Luo, Liqun","last_name":"Luo","first_name":"Liqun"},{"full_name":"Dalva, Matthew B.","last_name":"Dalva","first_name":"Matthew B."}],"_id":"6091","intvolume":"         8","quality_controlled":"1","date_published":"2019-02-21T00:00:00Z","month":"02","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2019-03-10T22:59:20Z","department":[{"_id":"SiHi"}],"publisher":"eLife Sciences Publications","citation":{"short":"N.T. Henderson, S.J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, M.B. Dalva, ELife 8 (2019).","mla":"Henderson, Nathan T., et al. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” <i>ELife</i>, vol. 8, e41563, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.41563\">10.7554/eLife.41563</a>.","ista":"Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. 2019. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. eLife. 8, e41563.","chicago":"Henderson, Nathan T., Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer, Liqun Luo, and Matthew B. Dalva. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.41563\">https://doi.org/10.7554/eLife.41563</a>.","ieee":"N. T. Henderson, S. J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, and M. B. Dalva, “Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","apa":"Henderson, N. T., Le Marchand, S. J., Hruska, M., Hippenmeyer, S., Luo, L., &#38; Dalva, M. B. (2019). Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.41563\">https://doi.org/10.7554/eLife.41563</a>","ama":"Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.41563\">10.7554/eLife.41563</a>"},"language":[{"iso":"eng"}],"article_number":"e41563","abstract":[{"text":"Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a factor that determines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling. In a microisland culture system designed to isolate cell-cell competition, we find that eB3 determines winning and losing neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM) genetic mouse model system in vivo the relative levels of eB3 control spine density in layer 5 and 6 neurons. MADM cortical neurons in vitro reveal that eB3 controls synapse density independently of action potential-driven activity. Our findings illustrate a new class of competitive mechanism mediated by trans-synaptic organizing proteins which control the number of synapses neurons receive relative to neighboring neurons.","lang":"eng"}],"oa":1,"day":"21","year":"2019","volume":8,"title":"Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs","doi":"10.7554/eLife.41563","publication_status":"published","file_date_updated":"2020-07-14T12:47:19Z","scopus_import":"1","ddc":["570"],"publication":"eLife","type":"journal_article","date_updated":"2023-08-24T14:50:50Z","article_processing_charge":"No"},{"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"author":[{"full_name":"Mentink, Johann H","first_name":"Johann H","last_name":"Mentink"},{"full_name":"Katsnelson, Mikhail","last_name":"Katsnelson","first_name":"Mikhail"},{"first_name":"Mikhail","last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802"}],"external_id":{"isi":["000459223400004"],"arxiv":["1802.01638"]},"arxiv":1,"issue":"6","intvolume":"        99","_id":"6092","project":[{"call_identifier":"FWF","_id":"26031614-B435-11E9-9278-68D0E5697425","name":"Quantum rotations in the presence of a many-body environment","grant_number":"P29902"}],"quality_controlled":"1","date_published":"2019-02-01T00:00:00Z","status":"public","month":"02","date_created":"2019-03-10T22:59:20Z","department":[{"_id":"MiLe"}],"citation":{"chicago":"Mentink, Johann H, Mikhail Katsnelson, and Mikhail Lemeshko. “Quantum Many-Body Dynamics of the Einstein-de Haas Effect.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">https://doi.org/10.1103/PhysRevB.99.064428</a>.","mla":"Mentink, Johann H., et al. “Quantum Many-Body Dynamics of the Einstein-de Haas Effect.” <i>Physical Review B</i>, vol. 99, no. 6, 064428, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">10.1103/PhysRevB.99.064428</a>.","short":"J.H. Mentink, M. Katsnelson, M. Lemeshko, Physical Review B 99 (2019).","ista":"Mentink JH, Katsnelson M, Lemeshko M. 2019. Quantum many-body dynamics of the Einstein-de Haas effect. Physical Review B. 99(6), 064428.","ama":"Mentink JH, Katsnelson M, Lemeshko M. Quantum many-body dynamics of the Einstein-de Haas effect. <i>Physical Review B</i>. 2019;99(6). doi:<a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">10.1103/PhysRevB.99.064428</a>","apa":"Mentink, J. H., Katsnelson, M., &#38; Lemeshko, M. (2019). Quantum many-body dynamics of the Einstein-de Haas effect. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">https://doi.org/10.1103/PhysRevB.99.064428</a>","ieee":"J. H. Mentink, M. Katsnelson, and M. Lemeshko, “Quantum many-body dynamics of the Einstein-de Haas effect,” <i>Physical Review B</i>, vol. 99, no. 6. American Physical Society, 2019."},"publisher":"American Physical Society","article_number":"064428","language":[{"iso":"eng"}],"abstract":[{"text":"In 1915, Einstein and de Haas and Barnett demonstrated that changing the magnetization of a magnetic material results in mechanical rotation and vice versa. At the microscopic level, this effect governs the transfer between electron spin and orbital angular momentum, and lattice degrees of freedom, understanding which is key for molecular magnets, nano-magneto-mechanics, spintronics, and ultrafast magnetism. Until now, the timescales of electron-to-lattice angular momentum transfer remain unclear, since modeling this process on a microscopic level requires the addition of an infinite amount of quantum angular momenta. We show that this problem can be solved by reformulating it in terms of the recently discovered angulon quasiparticles, which results in a rotationally invariant quantum many-body theory. In particular, we demonstrate that nonperturbative effects take place even if the electron-phonon coupling is weak and give rise to angular momentum transfer on femtosecond timescales.","lang":"eng"}],"day":"01","oa":1,"volume":99,"title":"Quantum many-body dynamics of the Einstein-de Haas effect","year":"2019","doi":"10.1103/PhysRevB.99.064428","publication_status":"published","main_file_link":[{"url":"https://arxiv.org/abs/1802.01638","open_access":"1"}],"scopus_import":"1","date_updated":"2025-04-15T07:59:29Z","publication":"Physical Review B","type":"journal_article","article_processing_charge":"No"},{"month":"03","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"page":"1375-1393","department":[{"_id":"NiBa"}],"date_created":"2019-03-10T22:59:21Z","citation":{"apa":"Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon, E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>","ieee":"R. Faria <i>et al.</i>, “Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes,” <i>Molecular Ecology</i>, vol. 28, no. 6. Wiley, pp. 1375–1393, 2019.","ama":"Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. 2019;28(6):1375-1393. doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>","mla":"Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>, vol. 28, no. 6, Wiley, 2019, pp. 1375–93, doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>.","short":"R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon, M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin, Molecular Ecology 28 (2019) 1375–1393.","ista":"Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular Ecology. 28(6), 1375–1393.","chicago":"Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon, Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>."},"publisher":"Wiley","_id":"6095","issue":"6","publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"intvolume":"        28","quality_controlled":"1","date_published":"2019-03-01T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","related_material":{"record":[{"relation":"research_data","id":"9837","status":"public"}]},"isi":1,"external_id":{"isi":["000465219200013"]},"author":[{"first_name":"Rui","last_name":"Faria","full_name":"Faria, Rui"},{"full_name":"Chaube, Pragya","last_name":"Chaube","first_name":"Pragya"},{"full_name":"Morales, Hernán E.","last_name":"Morales","first_name":"Hernán E."},{"first_name":"Tomas","last_name":"Larsson","full_name":"Larsson, Tomas"},{"last_name":"Lemmon","first_name":"Alan R.","full_name":"Lemmon, Alan R."},{"last_name":"Lemmon","first_name":"Emily M.","full_name":"Lemmon, Emily M."},{"full_name":"Rafajlović, Marina","first_name":"Marina","last_name":"Rafajlović"},{"last_name":"Panova","first_name":"Marina","full_name":"Panova, Marina"},{"first_name":"Mark","last_name":"Ravinet","full_name":"Ravinet, Mark"},{"full_name":"Johannesson, Kerstin","last_name":"Johannesson","first_name":"Kerstin"},{"first_name":"Anja M","last_name":"Westram","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"}],"file":[{"creator":"dernst","content_type":"application/pdf","file_id":"6097","date_updated":"2020-07-14T12:47:19Z","checksum":"f915885756057ec0ca5912a41f46a887","file_size":1510715,"file_name":"2019_MolecularEcology_Faria.pdf","date_created":"2019-03-11T16:12:54Z","relation":"main_file","access_level":"open_access"}],"has_accepted_license":"1","article_processing_charge":"No","scopus_import":"1","ddc":["570"],"type":"journal_article","publication":"Molecular Ecology","date_updated":"2023-08-24T14:50:27Z","doi":"10.1111/mec.14972","publication_status":"published","file_date_updated":"2020-07-14T12:47:19Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Both classical and recent studies suggest that chromosomal inversion polymorphisms are important in adaptation and speciation. However, biases in discovery and reporting of inversions make it difficult to assess their prevalence and biological importance. Here, we use an approach based on linkage disequilibrium among markers genotyped for samples collected across a transect between contrasting habitats to detect chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in a single locality for the coastal marine snail, Littorina saxatilis. Patterns of diversity in the field and of recombination in controlled crosses provide strong evidence that at least the majority of these rearrangements are inversions. Most show clinal changes in frequency between habitats, suggestive of divergent selection, but only one appears to be fixed for different arrangements in the two habitats. Consistent with widespread evidence for balancing selection on inversion polymorphisms, we argue that a combination of heterosis and divergent selection can explain the observed patterns and should be considered in other systems spanning environmental gradients."}],"oa":1,"day":"01","year":"2019","title":"Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes","volume":28},{"scopus_import":"1","ddc":["530"],"type":"journal_article","publication":"Light: Science and Applications","date_updated":"2025-07-10T11:53:10Z","article_processing_charge":"No","language":[{"iso":"eng"}],"article_number":"28","abstract":[{"lang":"eng","text":"Light is a union of electric and magnetic fields, and nowhere is the complex relationship between these fields more evident than in the near fields of nanophotonic structures. There, complicated electric and magnetic fields varying over subwavelength scales are generally present, which results in photonic phenomena such as extraordinary optical momentum, superchiral fields, and a complex spatial evolution of optical singularities. An understanding of such phenomena requires nanoscale measurements of the complete optical field vector. Although the sensitivity of near- field scanning optical microscopy to the complete electromagnetic field was recently demonstrated, a separation of different components required a priori knowledge of the sample. Here, we introduce a robust algorithm that can disentangle all six electric and magnetic field components from a single near-field measurement without any numerical modeling of the structure. As examples, we unravel the fields of two prototypical nanophotonic structures: a photonic crystal waveguide and a plasmonic nanowire. These results pave the way for new studies of complex photonic phenomena at the nanoscale and for the design of structures that optimize their optical behavior."}],"oa":1,"day":"06","year":"2019","title":"A full vectorial mapping of nanophotonic light fields","volume":8,"doi":"10.1038/s41377-019-0124-3","publication_status":"published","file_date_updated":"2020-07-14T12:47:19Z","_id":"6102","issue":"1","publication_identifier":{"issn":["2095-5545"],"eissn":["2047-7538"]},"intvolume":"         8","quality_controlled":"1","date_published":"2019-03-06T00:00:00Z","month":"03","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2019-03-17T22:59:13Z","department":[{"_id":"JoFi"}],"publisher":"Springer Nature","citation":{"chicago":"Le Feber, B., J. E. Sipe, Matthias Wulf, L. Kuipers, and N. Rotenberg. “A Full Vectorial Mapping of Nanophotonic Light Fields.” <i>Light: Science and Applications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41377-019-0124-3\">https://doi.org/10.1038/s41377-019-0124-3</a>.","short":"B. Le Feber, J.E. Sipe, M. Wulf, L. Kuipers, N. Rotenberg, Light: Science and Applications 8 (2019).","mla":"Le Feber, B., et al. “A Full Vectorial Mapping of Nanophotonic Light Fields.” <i>Light: Science and Applications</i>, vol. 8, no. 1, 28, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41377-019-0124-3\">10.1038/s41377-019-0124-3</a>.","ista":"Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. 2019. A full vectorial mapping of nanophotonic light fields. Light: Science and Applications. 8(1), 28.","apa":"Le Feber, B., Sipe, J. E., Wulf, M., Kuipers, L., &#38; Rotenberg, N. (2019). A full vectorial mapping of nanophotonic light fields. <i>Light: Science and Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41377-019-0124-3\">https://doi.org/10.1038/s41377-019-0124-3</a>","ieee":"B. Le Feber, J. E. Sipe, M. Wulf, L. Kuipers, and N. Rotenberg, “A full vectorial mapping of nanophotonic light fields,” <i>Light: Science and Applications</i>, vol. 8, no. 1. Springer Nature, 2019.","ama":"Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. A full vectorial mapping of nanophotonic light fields. <i>Light: Science and Applications</i>. 2019;8(1). doi:<a href=\"https://doi.org/10.1038/s41377-019-0124-3\">10.1038/s41377-019-0124-3</a>"},"file":[{"date_created":"2019-03-18T08:08:22Z","access_level":"open_access","relation":"main_file","file_name":"2019_Light_LeFeber.pdf","checksum":"d71e528cff9c56f70ccc29dd7005257f","file_size":1119947,"file_id":"6108","date_updated":"2020-07-14T12:47:19Z","creator":"dernst","content_type":"application/pdf"}],"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","isi":1,"arxiv":1,"external_id":{"arxiv":["1803.10145"],"isi":["000460470700004"]},"author":[{"last_name":"Le Feber","first_name":"B.","full_name":"Le Feber, B."},{"full_name":"Sipe, J. E.","first_name":"J. E.","last_name":"Sipe"},{"last_name":"Wulf","first_name":"Matthias","id":"45598606-F248-11E8-B48F-1D18A9856A87","full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378"},{"full_name":"Kuipers, L.","first_name":"L.","last_name":"Kuipers"},{"full_name":"Rotenberg, N.","last_name":"Rotenberg","first_name":"N."}]},{"scopus_import":"1","type":"journal_article","publication":"Plant and Cell Physiology","date_updated":"2023-08-25T08:05:28Z","article_processing_charge":"No","abstract":[{"text":"Abiotic stress poses constant challenges for plant survival and is a serious problem for global agricultural productivity. On a molecular level, stress conditions result in elevation of reactive oxygen species (ROS) production causing oxidative stress associated with oxidation of proteins and nucleic acids as well as impairment of membrane functions. Adaptation of root growth to ROS accumulation is facilitated through modification of auxin and cytokinin hormone homeostasis. Here, we report that in Arabidopsis root meristem, ROS-induced changes of auxin levels correspond to decreased abundance of PIN auxin efflux carriers at the plasma membrane (PM). Specifically, increase in H2O2 levels affects PIN2 endocytic recycling. We show that the PIN2 intracellular trafficking during adaptation to oxidative stress requires the function of the ADP-ribosylation factor (ARF)-guanine-nucleotide exchange factor (GEF) BEN1, an actin-associated regulator of the trafficking from the PM to early endosomes and, presumably, indirectly, trafficking to the vacuoles. We propose that H2O2 levels affect the actin dynamics thus modulating ARF-GEF-dependent trafficking of PIN2. This mechanism provides a way how root growth acclimates to stress and adapts to a changing environment.","lang":"eng"}],"language":[{"iso":"eng"}],"year":"2019","title":"Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking","volume":60,"day":"01","publication_status":"published","doi":"10.1093/pcp/pcz001","_id":"6104","intvolume":"        60","issue":"2","publication_identifier":{"issn":["0032-0781"],"eissn":["1471-9053"]},"date_published":"2019-02-01T00:00:00Z","quality_controlled":"1","page":"255-273","month":"02","status":"public","citation":{"chicago":"Zwiewka, Marta, Agnieszka Bielach, Prashanth Tamizhselvan, Sharmila Madhavan, Eman Elrefaay Ryad, Shutang Tan, Mónika Hrtyan, et al. “Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.” <i>Plant and Cell Physiology</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/pcp/pcz001\">https://doi.org/10.1093/pcp/pcz001</a>.","ista":"Zwiewka M, Bielach A, Tamizhselvan P, Madhavan S, Ryad EE, Tan S, Hrtyan M, Dobrev P, Vanková R, Friml J, Tognetti VB. 2019. Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. Plant and Cell Physiology. 60(2), 255–273.","mla":"Zwiewka, Marta, et al. “Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.” <i>Plant and Cell Physiology</i>, vol. 60, no. 2, Oxford University Press, 2019, pp. 255–73, doi:<a href=\"https://doi.org/10.1093/pcp/pcz001\">10.1093/pcp/pcz001</a>.","short":"M. Zwiewka, A. Bielach, P. Tamizhselvan, S. Madhavan, E.E. Ryad, S. Tan, M. Hrtyan, P. Dobrev, R. Vanková, J. Friml, V.B. Tognetti, Plant and Cell Physiology 60 (2019) 255–273.","ama":"Zwiewka M, Bielach A, Tamizhselvan P, et al. Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. <i>Plant and Cell Physiology</i>. 2019;60(2):255-273. doi:<a href=\"https://doi.org/10.1093/pcp/pcz001\">10.1093/pcp/pcz001</a>","ieee":"M. Zwiewka <i>et al.</i>, “Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking,” <i>Plant and Cell Physiology</i>, vol. 60, no. 2. Oxford University Press, pp. 255–273, 2019.","apa":"Zwiewka, M., Bielach, A., Tamizhselvan, P., Madhavan, S., Ryad, E. E., Tan, S., … Tognetti, V. B. (2019). Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. <i>Plant and Cell Physiology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/pcp/pcz001\">https://doi.org/10.1093/pcp/pcz001</a>"},"publisher":"Oxford University Press","department":[{"_id":"JiFr"}],"date_created":"2019-03-17T22:59:14Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"None","external_id":{"isi":["000459634300002"],"pmid":["30668780"]},"author":[{"first_name":"Marta","last_name":"Zwiewka","full_name":"Zwiewka, Marta"},{"first_name":"Agnieszka","last_name":"Bielach","full_name":"Bielach, Agnieszka"},{"first_name":"Prashanth","last_name":"Tamizhselvan","full_name":"Tamizhselvan, Prashanth"},{"first_name":"Sharmila","last_name":"Madhavan","full_name":"Madhavan, Sharmila"},{"full_name":"Ryad, Eman Elrefaay","first_name":"Eman Elrefaay","last_name":"Ryad"},{"first_name":"Shutang","last_name":"Tan","full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hrtyan, Mónika","id":"45A71A74-F248-11E8-B48F-1D18A9856A87","last_name":"Hrtyan","first_name":"Mónika"},{"full_name":"Dobrev, Petre","first_name":"Petre","last_name":"Dobrev"},{"last_name":"Vanková","first_name":"Radomira","full_name":"Vanková, Radomira"},{"last_name":"Friml","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596"},{"first_name":"Vanesa B.","last_name":"Tognetti","full_name":"Tognetti, Vanesa B."}],"pmid":1,"isi":1},{"has_accepted_license":"1","file":[{"file_name":"2019_JournalAnimalEcology_Kutzer.pdf","checksum":"405cde15120de26018b3bd0dfa29986c","file_size":1460662,"access_level":"open_access","relation":"main_file","date_created":"2019-03-18T07:43:06Z","content_type":"application/pdf","creator":"dernst","file_id":"6107","date_updated":"2020-07-14T12:47:19Z"}],"author":[{"first_name":"Megan","last_name":"Kutzer","full_name":"Kutzer, Megan","orcid":"0000-0002-8696-6978","id":"29D0B332-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kurtz, Joachim","last_name":"Kurtz","first_name":"Joachim"},{"last_name":"Armitage","first_name":"Sophie A.O.","full_name":"Armitage, Sophie A.O."}],"external_id":{"isi":["000467994800007"]},"isi":1,"oa_version":"Published Version","related_material":{"record":[{"relation":"research_data","id":"9806","status":"public"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2019-04-01T00:00:00Z","quality_controlled":"1","project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734"}],"publication_identifier":{"eissn":["1365-2656"],"issn":["0021-8790"]},"intvolume":"        88","issue":"4","_id":"6105","citation":{"ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance,” <i>Journal of Animal Ecology</i>, vol. 88, no. 4. Wiley, pp. 566–578, 2019.","ama":"Kutzer M, Kurtz J, Armitage SAO. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. 2019;88(4):566-578. doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>","apa":"Kutzer, M., Kurtz, J., &#38; Armitage, S. A. O. (2019). A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>","ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. 88(4), 566–578.","mla":"Kutzer, Megan, et al. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>, vol. 88, no. 4, Wiley, 2019, pp. 566–78, doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>.","short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, Journal of Animal Ecology 88 (2019) 566–578.","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>."},"publisher":"Wiley","department":[{"_id":"SyCr"}],"date_created":"2019-03-17T22:59:15Z","page":"566-578","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"04","title":"A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance","volume":88,"year":"2019","day":"01","oa":1,"abstract":[{"lang":"eng","text":"    Hosts can alter their strategy towards pathogens during their lifetime; that is, they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e., resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fecundity consequences that result from a high pathogen burden. Finally, previous exposure may also lead to life‐history adjustments, such as terminal investment into reproduction.\r\n    Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested whether previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute‐phase infection (one day post‐challenge). We then asked whether previous pathogen exposure affects chronic‐phase pathogen persistence and longer‐term survival (28 days post‐challenge).\r\n    We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long‐term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses.\r\n    We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection.\r\n    To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi‐faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host–pathogen system and that infection persistence may be bacterium‐specific.\r\n"}],"language":[{"iso":"eng"}],"ec_funded":1,"file_date_updated":"2020-07-14T12:47:19Z","publication_status":"published","doi":"10.1111/1365-2656.12953","date_updated":"2025-07-10T11:53:10Z","type":"journal_article","publication":"Journal of Animal Ecology","ddc":["570"],"scopus_import":"1","article_type":"original","article_processing_charge":"No"},{"main_file_link":[{"url":"https://arxiv.org/abs/1811.03103","open_access":"1"}],"publication_status":"published","doi":"10.1103/physrevb.99.094205","volume":99,"title":"Kosterlitz-Thouless scaling at many-body localization phase transitions","year":"2019","day":"22","oa":1,"abstract":[{"lang":"eng","text":"We propose a scaling theory for the many-body localization (MBL) phase transition in one dimension, building on the idea that it proceeds via a “quantum avalanche.” We argue that the critical properties can be captured at a coarse-grained level by a Kosterlitz-Thouless (KT) renormalization group (RG) flow. On phenomenological grounds, we identify the scaling variables as the density of thermal regions and the length scale that controls the decay of typical matrix elements. Within this KT picture, the MBL phase is a line of fixed points that terminates at the delocalization transition. We discuss two possible scenarios distinguished by the distribution of rare, fractal thermal inclusions within the MBL phase. In the first scenario, these regions have a stretched exponential distribution in the MBL phase. In the second scenario, the near-critical MBL phase hosts rare thermal regions that are power-law-distributed in size. This points to the existence of a second transition within the MBL phase, at which these power laws change to the stretched exponential form expected at strong disorder. We numerically simulate two different phenomenological RGs previously proposed to describe the MBL transition. Both RGs display a universal power-law length distribution of thermal regions at the transition with a critical exponent αc=2, and continuously varying exponents in the MBL phase consistent with the KT picture."}],"language":[{"iso":"eng"}],"article_number":"094205","article_type":"original","article_processing_charge":"No","date_updated":"2023-09-05T12:11:13Z","publication":"Physical Review B","type":"journal_article","scopus_import":"1","author":[{"last_name":"Dumitrescu","first_name":"Philipp T.","full_name":"Dumitrescu, Philipp T."},{"full_name":"Goremykina, Anna","last_name":"Goremykina","first_name":"Anna"},{"full_name":"Parameswaran, Siddharth A.","last_name":"Parameswaran","first_name":"Siddharth A."},{"full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827","first_name":"Maksym","last_name":"Serbyn"},{"full_name":"Vasseur, Romain","last_name":"Vasseur","first_name":"Romain"}],"external_id":{"isi":["000462883200001"],"arxiv":["1811.03103"]},"arxiv":1,"isi":1,"oa_version":"Preprint","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publisher":"American Physical Society","citation":{"ista":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. 2019. Kosterlitz-Thouless scaling at many-body localization phase transitions. Physical Review B. 99(9), 094205.","mla":"Dumitrescu, Philipp T., et al. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>, vol. 99, no. 9, 094205, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>.","short":"P.T. Dumitrescu, A. Goremykina, S.A. Parameswaran, M. Serbyn, R. Vasseur, Physical Review B 99 (2019).","chicago":"Dumitrescu, Philipp T., Anna Goremykina, Siddharth A. Parameswaran, Maksym Serbyn, and Romain Vasseur. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>.","apa":"Dumitrescu, P. T., Goremykina, A., Parameswaran, S. A., Serbyn, M., &#38; Vasseur, R. (2019). Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>","ieee":"P. T. Dumitrescu, A. Goremykina, S. A. Parameswaran, M. Serbyn, and R. Vasseur, “Kosterlitz-Thouless scaling at many-body localization phase transitions,” <i>Physical Review B</i>, vol. 99, no. 9. American Physical Society, 2019.","ama":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. 2019;99(9). doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>"},"department":[{"_id":"MaSe"}],"date_created":"2019-03-25T07:32:08Z","status":"public","month":"03","date_published":"2019-03-22T00:00:00Z","quality_controlled":"1","issue":"9","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"intvolume":"        99","_id":"6174"},{"_id":"6190","intvolume":"        17","issue":"3","publication_identifier":{"issn":["1541-7786"],"eissn":["1557-3125"]},"date_published":"2019-03-01T00:00:00Z","quality_controlled":"1","page":"783-793","month":"03","status":"public","publisher":"AACR","citation":{"ama":"Roblek M, Protsyuk D, Becker PF, et al. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. 2019;17(3):783-793. doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>","ieee":"M. Roblek <i>et al.</i>, “CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis,” <i>Molecular Cancer Research</i>, vol. 17, no. 3. AACR, pp. 783–793, 2019.","apa":"Roblek, M., Protsyuk, D., Becker, P. F., Stefanescu, C., Gorzelanny, C., Glaus Garzon, J. F., … Borsig, L. (2019). CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. AACR. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>","mla":"Roblek, Marko, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>, vol. 17, no. 3, AACR, 2019, pp. 783–93, doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>.","short":"M. Roblek, D. Protsyuk, P.F. Becker, C. Stefanescu, C. Gorzelanny, J.F. Glaus Garzon, L. Knopfova, M. Heikenwalder, B. Luckow, S.W. Schneider, L. Borsig, Molecular Cancer Research 17 (2019) 783–793.","ista":"Roblek M, Protsyuk D, Becker PF, Stefanescu C, Gorzelanny C, Glaus Garzon JF, Knopfova L, Heikenwalder M, Luckow B, Schneider SW, Borsig L. 2019. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. Molecular Cancer Research. 17(3), 783–793.","chicago":"Roblek, Marko, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>. AACR, 2019. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>."},"department":[{"_id":"DaSi"}],"date_created":"2019-03-31T21:59:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","external_id":{"pmid":["30552233"],"isi":["000460099800012"]},"pmid":1,"author":[{"first_name":"Marko","last_name":"Roblek","id":"3047D808-F248-11E8-B48F-1D18A9856A87","full_name":"Roblek, Marko","orcid":"0000-0001-9588-1389"},{"last_name":"Protsyuk","first_name":"Darya","full_name":"Protsyuk, Darya"},{"full_name":"Becker, Paul F.","last_name":"Becker","first_name":"Paul F."},{"last_name":"Stefanescu","first_name":"Cristina","full_name":"Stefanescu, Cristina"},{"full_name":"Gorzelanny, Christian","last_name":"Gorzelanny","first_name":"Christian"},{"full_name":"Glaus Garzon, Jesus F.","first_name":"Jesus F.","last_name":"Glaus Garzon"},{"full_name":"Knopfova, Lucia","last_name":"Knopfova","first_name":"Lucia"},{"full_name":"Heikenwalder, Mathias","first_name":"Mathias","last_name":"Heikenwalder"},{"first_name":"Bruno","last_name":"Luckow","full_name":"Luckow, Bruno"},{"full_name":"Schneider, Stefan W.","last_name":"Schneider","first_name":"Stefan W."},{"full_name":"Borsig, Lubor","last_name":"Borsig","first_name":"Lubor"}],"isi":1,"scopus_import":"1","type":"journal_article","publication":"Molecular Cancer Research","date_updated":"2025-07-10T11:53:14Z","article_type":"original","article_processing_charge":"No","abstract":[{"text":"Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions of Ccr2ecKO and Ccr2fl/fl littermates were observed. The absence of endothelial Ccr2 strongly reduced pulmonary metastasis, while the primary tumor growth was unaffected. Despite a comparable cytokine milieu in Ccr2ecKO and Ccr2fl/fl littermates the absence of vascular permeability induction was observed only in Ccr2ecKO mice. CCL2 stimulation of pulmonary endothelial cells resulted in increased phosphorylation of MLC2, endothelial cell retraction, and vascular leakiness that was blocked by an addition of a CCR2 inhibitor. These data demonstrate that endothelial CCR2 expression is required for tumor cell extravasation and pulmonary metastasis.\r\n\r\nImplications: The findings provide mechanistic insight into how CCL2–CCR2 signaling in endothelial cells promotes their activation through myosin light chain phosphorylation, resulting in endothelial retraction and enhanced tumor cell migration and metastasis.","lang":"eng"}],"language":[{"iso":"eng"}],"year":"2019","volume":17,"title":"CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis","oa":1,"day":"01","publication_status":"published","doi":"10.1158/1541-7786.MCR-18-0530","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1158/1541-7786.MCR-18-0530"}]}]