---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21274'
abstract:
- lang: eng
  text: "Many white dwarfs are observed in compact double white dwarf binaries, and
    through the emission of gravitational waves, a large fraction are destined to
    merge. The merger remnants that do not explode in a Type Ia supernova are expected
    to initially be rapidly rotating and highly magnetized. In this work, we present
    our discovery of the variable white dwarf ZTF J200832.79+444939.67, hereafter
    ZTF J2008+4449, as a likely merger remnant showing signs of circumstellar material
    without a stellar or substellar companion. The nature of ZTF J2008+4449 as a merger
    remnant is supported by its physical properties: it is hot (35 500 ± 300 K) and
    massive (1.12 ± 0.03 M\r\n                    <jats:sub>⊙</jats:sub>\r\n                    ),
    rapidly rotating with a period of ≈6.6 minutes, and likely possesses exceptionally
    strong magnetic fields (∼400−600 MG) at its surface. Remarkably, we detect a significant
    period derivative of (1.80 ± 0.09)×10\r\n                    <jats:sup>−12</jats:sup>\r\n
    \                   s/s, indicating that the white dwarf is spinning down, and
    a soft X-ray emission that is inconsistent with photospheric emission. As the
    presence of a mass-transferring stellar or brown dwarf companion is excluded by
    infrared photometry, the detected spin-down and X-ray emission could be tell-tale
    signs of a magnetically driven wind or of interaction with circumstellar material,
    possibly originating from the fallback of gravitationally bound merger ejecta
    or from the tidal disruption of a planetary object. We also detect Balmer emission,
    which requires the presence of ionized hydrogen in the vicinity of the white dwarf,
    showing Doppler shifts as high as ≈2000 km s\r\n                    <jats:sup>−1</jats:sup>\r\n
    \                   . The unusual variability of the Balmer emission on the spin
    period of the white dwarf is consistent with the trapping of a half ring of ionized
    gas in the magnetosphere of the white dwarf.\r\n                  </jats:p>"
acknowledgement: "We thank Lynne Hillenbrand and Soumyadeep Bhattacharjee for helpful
  discussions, and Kishalay De for his help with the WIRC\r\nreduction pipeline. IC
  was supported by NASA through grants from the Space\r\nTelescope Science Institute,
  under NASA contracts NASA.22K1813, NAS5-\r\n26555 and NAS5-03127. TC was supported
  by NASA through the NASA Hubble\r\nFellowship grant HST-HF2-51527.001-A awarded
  by the Space Telescope Science Institute, which is operated by the Association of
  Universities for Research\r\nin Astronomy, Inc., for NASA, under contract NAS5-26555.
  This project has\r\nreceived funding from the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation programme (Grant agreement
  No. 101020057). This work was based on observations obtained with the\r\nSamuel
  Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar\r\nObservatory
  as part of the Zwicky Transient Facility project. ZTF is supported\r\nby the National
  Science Foundation under Grants No. AST-1440341, AST2034437, and currently Award
  #2407588. ZTF receives additional funding from\r\nthe ZTF partnership. Current members
  include Caltech, USA; Caltech/IPAC,\r\nUSA; University of Maryland, USA; University
  of California, Berkeley, USA;\r\nUniversity of Wisconsin at Milwaukee, USA; Cornell
  University, USA; Drexel\r\nUniversity, USA; University of North Carolina at Chapel
  Hill, USA; Institute\r\nof Science and Technology, Austria; National Central University,
  Taiwan, and\r\nOKC, University of Stockholm, Sweden. Operations are conducted by
  Caltech’s\r\nOptical Observatory (COO), Caltech/IPAC, and the University of Washington
  at\r\nSeattle, USA. This work has made use of data from the European Space Agency\r\n(ESA)
  mission Gaia (https://www.cosmos.esa.int/gaia), processed by\r\nthe Gaia Data Processing
  and Analysis Consortium (DPAC, https://www.\r\ncosmos.esa.int/web/gaia/dpac/consortium).
  Funding for the DPAC has been provided by national institutions, in particular the
  institutions participating in the Gaia Multilateral Agreement. The Pan-STARRS1 Surveys
  (PS1)\r\nand the PS1 public science archive have been made possible through contributions
  by the Institute for Astronomy, the University of Hawaii, the PanSTARRS Project
  Office, the Max-Planck Society and its participating institutes, the Max Planck
  Institute for Astronomy, Heidelberg and the Max Planck\r\nInstitute for Extraterrestrial
  Physics, Garching, The Johns Hopkins University,\r\nDurham University, the University
  of Edinburgh, the Queen’s University Belfast,\r\nthe Harvard-Smithsonian Center
  for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated,
  the National Central University of Taiwan, the Space Telescope Science Institute,
  the National Aeronautics and Space Administration under Grant No. NNX08AR22G issued
  through\r\nthe Planetary Science Division of the NASA Science Mission Directorate,
  the\r\nNational Science Foundation Grant No. AST–1238877, the University of Maryland,
  Eotvos Lorand University (ELTE), the Los Alamos National Laboratory,\r\nand the
  Gordon and Betty Moore Foundation. This work made use of Astropy\r\n(http://www.astropy.org):
  a community-developed core Python package\r\nand an ecosystem of tools and resources
  for astronomy (Astropy Collaboration\r\n2013, 2018, 2022)."
article_number: A188
article_processing_charge: Yes
article_type: original
author:
- first_name: Andrei-Alexandru
  full_name: Cristea, Andrei-Alexandru
  id: 4d500bea-31f8-11ee-a48d-d4904fb363c7
  last_name: Cristea
- first_name: Ilaria
  full_name: Caiazzo, Ilaria
  id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
  last_name: Caiazzo
  orcid: 0000-0002-4770-5388
- first_name: Tim
  full_name: Cunningham, Tim
  last_name: Cunningham
- first_name: John C.
  full_name: Raymond, John C.
  last_name: Raymond
- first_name: Stephane
  full_name: Vennes, Stephane
  last_name: Vennes
- first_name: Adela
  full_name: Kawka, Adela
  last_name: Kawka
- first_name: Aayush A
  full_name: Desai, Aayush A
  id: 502cfd30-32c1-11ee-a9a4-d8dad5c6739e
  last_name: Desai
- first_name: David R.
  full_name: Miller, David R.
  last_name: Miller
- first_name: J. J.
  full_name: Hermes, J. J.
  last_name: Hermes
- first_name: Jim
  full_name: Fuller, Jim
  last_name: Fuller
- first_name: Jeremy
  full_name: Heyl, Jeremy
  last_name: Heyl
- first_name: Jan
  full_name: van Roestel, Jan
  last_name: van Roestel
- first_name: Kevin B.
  full_name: Burdge, Kevin B.
  last_name: Burdge
- first_name: Antonio C.
  full_name: Rodriguez, Antonio C.
  last_name: Rodriguez
- first_name: Ingrid
  full_name: Pelisoli, Ingrid
  last_name: Pelisoli
- first_name: Boris T.
  full_name: Gänsicke, Boris T.
  last_name: Gänsicke
- first_name: Paula
  full_name: Szkody, Paula
  last_name: Szkody
- first_name: Scott J.
  full_name: Kenyon, Scott J.
  last_name: Kenyon
- first_name: Zach
  full_name: Vanderbosch, Zach
  last_name: Vanderbosch
- first_name: Andrew
  full_name: Drake, Andrew
  last_name: Drake
- first_name: Lilia
  full_name: Ferrario, Lilia
  last_name: Ferrario
- first_name: Dayal
  full_name: Wickramasinghe, Dayal
  last_name: Wickramasinghe
- first_name: Viraj R.
  full_name: Karambelkar, Viraj R.
  last_name: Karambelkar
- first_name: Stephen
  full_name: Justham, Stephen
  last_name: Justham
- first_name: Ruediger
  full_name: Pakmor, Ruediger
  last_name: Pakmor
- first_name: Kareem
  full_name: El-Badry, Kareem
  last_name: El-Badry
- first_name: Thomas
  full_name: Prince, Thomas
  last_name: Prince
- first_name: S. R.
  full_name: Kulkarni, S. R.
  last_name: Kulkarni
- first_name: Matthew J.
  full_name: Graham, Matthew J.
  last_name: Graham
- first_name: Frank J.
  full_name: Masci, Frank J.
  last_name: Masci
- first_name: Steven L.
  full_name: Groom, Steven L.
  last_name: Groom
- first_name: Josiah
  full_name: Purdum, Josiah
  last_name: Purdum
- first_name: Richard
  full_name: Dekany, Richard
  last_name: Dekany
- first_name: Eric C.
  full_name: Bellm, Eric C.
  last_name: Bellm
citation:
  ama: Cristea A-A, Caiazzo I, Cunningham T, et al. A half ring of ionized circumstellar
    material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy
    &#38; Astrophysics</i>. 2026;706. doi:<a href="https://doi.org/10.1051/0004-6361/202556432">10.1051/0004-6361/202556432</a>
  apa: Cristea, A.-A., Caiazzo, I., Cunningham, T., Raymond, J. C., Vennes, S., Kawka,
    A., … Bellm, E. C. (2026). A half ring of ionized circumstellar material trapped
    in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>.
    EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202556432">https://doi.org/10.1051/0004-6361/202556432</a>
  chicago: Cristea, Andrei-Alexandru, Ilaria Caiazzo, Tim Cunningham, John C. Raymond,
    Stephane Vennes, Adela Kawka, Aayush A Desai, et al. “A Half Ring of Ionized Circumstellar
    Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy
    &#38; Astrophysics</i>. EDP Sciences, 2026. <a href="https://doi.org/10.1051/0004-6361/202556432">https://doi.org/10.1051/0004-6361/202556432</a>.
  ieee: A.-A. Cristea <i>et al.</i>, “A half ring of ionized circumstellar material
    trapped in the magnetosphere of a white dwarf merger remnant,” <i>Astronomy &#38;
    Astrophysics</i>, vol. 706. EDP Sciences, 2026.
  ista: Cristea A-A, Caiazzo I, Cunningham T, Raymond JC, Vennes S, Kawka A, Desai
    AA, Miller DR, Hermes JJ, Fuller J, Heyl J, van Roestel J, Burdge KB, Rodriguez
    AC, Pelisoli I, Gänsicke BT, Szkody P, Kenyon SJ, Vanderbosch Z, Drake A, Ferrario
    L, Wickramasinghe D, Karambelkar VR, Justham S, Pakmor R, El-Badry K, Prince T,
    Kulkarni SR, Graham MJ, Masci FJ, Groom SL, Purdum J, Dekany R, Bellm EC. 2026.
    A half ring of ionized circumstellar material trapped in the magnetosphere of
    a white dwarf merger remnant. Astronomy &#38; Astrophysics. 706, A188.
  mla: Cristea, Andrei-Alexandru, et al. “A Half Ring of Ionized Circumstellar Material
    Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38;
    Astrophysics</i>, vol. 706, A188, EDP Sciences, 2026, doi:<a href="https://doi.org/10.1051/0004-6361/202556432">10.1051/0004-6361/202556432</a>.
  short: A.-A. Cristea, I. Caiazzo, T. Cunningham, J.C. Raymond, S. Vennes, A. Kawka,
    A.A. Desai, D.R. Miller, J.J. Hermes, J. Fuller, J. Heyl, J. van Roestel, K.B.
    Burdge, A.C. Rodriguez, I. Pelisoli, B.T. Gänsicke, P. Szkody, S.J. Kenyon, Z.
    Vanderbosch, A. Drake, L. Ferrario, D. Wickramasinghe, V.R. Karambelkar, S. Justham,
    R. Pakmor, K. El-Badry, T. Prince, S.R. Kulkarni, M.J. Graham, F.J. Masci, S.L.
    Groom, J. Purdum, R. Dekany, E.C. Bellm, Astronomy &#38; Astrophysics 706 (2026).
corr_author: '1'
date_created: 2026-02-17T08:12:05Z
date_published: 2026-02-10T00:00:00Z
date_updated: 2026-04-28T12:01:21Z
day: '10'
ddc:
- '520'
department:
- _id: IlCa
- _id: GradSch
doi: 10.1051/0004-6361/202556432
file:
- access_level: open_access
  checksum: 229b688e6e78cab5bb8e2bac366d1575
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T12:04:37Z
  date_updated: 2026-02-23T12:04:37Z
  file_id: '21350'
  file_name: 2026_AstronomyAstrophysics_Cristea.pdf
  file_size: 5352853
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T12:04:37Z
has_accepted_license: '1'
intvolume: '       706'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/twos-company-new-class-of-star-remnants/
status: public
title: A half ring of ionized circumstellar material trapped in the magnetosphere
  of a white dwarf merger remnant
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 706
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21485'
abstract:
- lang: eng
  text: Insulating oxides are among the most abundant solid materials in the universe1,2,3.
    Of the many ways in which they influence natural phenomena, perhaps the most consequential
    is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which
    occurs even between samples of the same oxide—yet the symmetry-breaking parameter
    that causes this remains unidentified11,12. Here we show that adventitious carbonaceous
    molecules adsorbed from the environment are the symmetry-breaking factor in same-material
    oxide contact electrification (CE). We use acoustic levitation to measure charge
    exchange between a sphere and a plate composed of identical amorphous silicon
    dioxide (SiO2). Although charging polarity is random for co-prepared samples,
    we control it with baking or plasma treatment. Observing the charge-exchange relaxation
    afterwards, we see dynamics over a timescale of hours and connect this directly
    to the presence of adventitious carbon with time-of-flight mass spectrometry,
    low-energy ion scattering and infrared spectroscopy. Going further, we confirm
    that adventitious carbon can even determine charge exchange among different oxides.
    Our results identify the symmetry-breaking parameter that causes insulating oxides
    to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6,
    while simultaneously highlighting an overlooked factor in CE more broadly.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
- _id: LifeSc
acknowledgement: This project has received support from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant
  agreement no. 754411). We acknowledge the state of Lower Austria and the European
  Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges
  support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research
  was supported by the Scientific Service Units of the Institute of Science and Technology
  Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility,
  Scientific Computing facility and Lab Support Facility. We thank the Modic group
  for the use of the Laue camera, T. Zauner for the photography of the experimental
  set-up and R. Möller for insightful discussions. Open access funding provided by
  Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Galien M
  full_name: Grosjean, Galien M
  id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425
  last_name: Grosjean
  orcid: 0000-0001-5154-417X
- first_name: Markus
  full_name: Ostermann, Markus
  last_name: Ostermann
- first_name: Markus
  full_name: Sauer, Markus
  last_name: Sauer
- first_name: Michael
  full_name: Hahn, Michael
  last_name: Hahn
- first_name: Christian M.
  full_name: Pichler, Christian M.
  last_name: Pichler
- first_name: Florian
  full_name: Fahrnberger, Florian
  last_name: Fahrnberger
- first_name: Felix
  full_name: Pertl, Felix
  id: 6313aec0-15b2-11ec-abd3-ed67d16139af
  last_name: Pertl
  orcid: 0000-0003-0463-5794
- first_name: Daniel
  full_name: Balazs, Daniel
  id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
  last_name: Balazs
  orcid: 0000-0001-7597-043X
- first_name: Mason M.
  full_name: Link, Mason M.
  last_name: Link
- first_name: Seong H.
  full_name: Kim, Seong H.
  last_name: Kim
- first_name: Devin L.
  full_name: Schrader, Devin L.
  last_name: Schrader
- first_name: Adriana
  full_name: Blanco, Adriana
  last_name: Blanco
- first_name: Francisco
  full_name: Gracia, Francisco
  last_name: Gracia
- first_name: Nicolás
  full_name: Mujica, Nicolás
  last_name: Mujica
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
citation:
  ama: Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry
    in oxide contact electrification. <i>Nature</i>. 2026;651(8106):626-631. doi:<a
    href="https://doi.org/10.1038/s41586-025-10088-w">10.1038/s41586-025-10088-w</a>
  apa: Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger,
    F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide
    contact electrification. <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-025-10088-w">https://doi.org/10.1038/s41586-025-10088-w</a>
  chicago: Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian
    M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks
    Symmetry in Oxide Contact Electrification.” <i>Nature</i>. Springer Nature, 2026.
    <a href="https://doi.org/10.1038/s41586-025-10088-w">https://doi.org/10.1038/s41586-025-10088-w</a>.
  ieee: G. M. Grosjean <i>et al.</i>, “Adventitious carbon breaks symmetry in oxide
    contact electrification,” <i>Nature</i>, vol. 651, no. 8106. Springer Nature,
    pp. 626–631, 2026.
  ista: Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl
    F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis
    SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification.
    Nature. 651(8106), 626–631.
  mla: Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact
    Electrification.” <i>Nature</i>, vol. 651, no. 8106, Springer Nature, 2026, pp.
    626–31, doi:<a href="https://doi.org/10.1038/s41586-025-10088-w">10.1038/s41586-025-10088-w</a>.
  short: G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger,
    F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia,
    N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.
corr_author: '1'
date_created: 2026-03-23T15:04:00Z
date_published: 2026-03-18T00:00:00Z
date_updated: 2026-04-28T12:06:01Z
day: '18'
ddc:
- '540'
department:
- _id: ScWa
- _id: GradSch
- _id: LifeSc
doi: 10.1038/s41586-025-10088-w
ec_funded: 1
external_id:
  pmid:
  - '41851325'
file:
- access_level: open_access
  checksum: dafef9ed575b44be4263e948a47ae056
  content_type: application/pdf
  creator: dernst
  date_created: 2026-03-24T06:57:08Z
  date_updated: 2026-03-24T06:57:08Z
  file_id: '21494'
  file_name: 2026_Nature_Grosjean.pdf
  file_size: 12245694
  relation: main_file
  success: 1
file_date_updated: 2026-03-24T06:57:08Z
has_accepted_license: '1'
intvolume: '       651'
issue: '8106'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 626-631
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
  call_identifier: H2020
  grant_number: '949120'
  name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/
status: public
title: Adventitious carbon breaks symmetry in oxide contact electrification
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 651
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21015'
abstract:
- lang: eng
  text: Early embryo geometry is one of the most invariant species-specific traits,
    yet its role in ensuring developmental reproducibility and robustness remains
    underexplored. Here we show that in zebrafish, the geometry of the fertilized
    egg—specifically its curvature and volume—serves as a critical initial condition
    triggering a cascade of events that influence development. The embryo geometry
    guides patterned asymmetric cell divisions in the blastoderm, generating radial
    gradients of cell volume and nucleocytoplasmic ratio. These gradients generate
    mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell
    cycle periods independently of other cells. We demonstrate that reducing cell
    autonomy reshapes these waves, emphasizing the instructive role of geometry-derived
    volume patterns in setting the intrinsic period of the cell cycle oscillator.
    In addition to organizing cell cycles, early embryo geometry spatially patterns
    zygotic genome activation at the midblastula transition, a key step in establishing
    embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation
    pattern and causes ectopic germ layer specification, underscoring the developmental
    significance of geometry. Together, our findings reveal a symmetry-breaking function
    of early embryo geometry in coordinating cell cycle and transcriptional patterning.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: ScienComp
- _id: LifeSc
acknowledgement: We thank N. Petridou (EMBL) for sharing results before publication.
  N.M. was supported by funding from the European Union’s Horizon 2020 programme under
  the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411.
  Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and
  innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413.
  The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project
  ID 1.844. We would like to thank past and present members of the Heisenberg and
  Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic,
  N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript.
  This research was supported by the Scientific Service Units (SSU) of Institute of
  Science and Technology Austria through resources provided by the Aquatics Facility,
  Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab
  Support Facility (LSF). Open access funding provided by Institute of Science and
  Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nikhil
  full_name: Mishra, Nikhil
  id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
  last_name: Mishra
  orcid: 0000-0002-6425-5788
- first_name: Yuting I
  full_name: Li, Yuting I
  id: ee7a5ca8-8b71-11ed-b662-b3341c05b7eb
  last_name: Li
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell
    divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo.
    <i>Nature Physics</i>. 2026;22:139-150. doi:<a href="https://doi.org/10.1038/s41567-025-03122-1">10.1038/s41567-025-03122-1</a>
  apa: Mishra, N., Li, Y. I., Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2026). Geometry-driven
    asymmetric cell divisions pattern cell cycles and zygotic genome activation in
    the zebrafish embryo. <i>Nature Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-025-03122-1">https://doi.org/10.1038/s41567-025-03122-1</a>
  chicago: Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg.
    “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome
    Activation in the Zebrafish Embryo.” <i>Nature Physics</i>. Springer Nature, 2026.
    <a href="https://doi.org/10.1038/s41567-025-03122-1">https://doi.org/10.1038/s41567-025-03122-1</a>.
  ieee: N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven
    asymmetric cell divisions pattern cell cycles and zygotic genome activation in
    the zebrafish embryo,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 139–150,
    2026.
  ista: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric
    cell divisions pattern cell cycles and zygotic genome activation in the zebrafish
    embryo. Nature Physics. 22, 139–150.
  mla: Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell
    Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” <i>Nature Physics</i>,
    vol. 22, Springer Nature, 2026, pp. 139–50, doi:<a href="https://doi.org/10.1038/s41567-025-03122-1">10.1038/s41567-025-03122-1</a>.
  short: N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026)
    139–150.
corr_author: '1'
date_created: 2026-01-20T10:12:19Z
date_published: 2026-01-05T00:00:00Z
date_updated: 2026-04-28T12:55:30Z
day: '05'
ddc:
- '570'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1038/s41567-025-03122-1
ec_funded: 1
external_id:
  oaworkid:
  - W7118187193
file:
- access_level: open_access
  checksum: 0ab7ac2fbcb61a364dba57152db64ed7
  content_type: application/pdf
  creator: dernst
  date_created: 2026-01-21T08:21:11Z
  date_updated: 2026-01-21T08:21:11Z
  file_id: '21026'
  file_name: 2026_NaturePhysics_Mishra.pdf
  file_size: 7335694
  relation: main_file
  success: 1
file_date_updated: 2026-01-21T08:21:11Z
has_accepted_license: '1'
intvolume: '        22'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
oaworkid: 1
page: 139-150
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: 917c023a-16d5-11f0-9cad-eb5cafc52090
  name: Cytoplasmic self-organization into cell-like compartments as a common guiding
    principle in early animal development
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
  issnl:
  - ' 1745-2473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: research_data
    url: https://ista.ac.at/en/news/geometry-shapes-life/
scopus_import: '1'
status: public
title: Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome
  activation in the zebrafish embryo
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 22
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21382'
abstract:
- lang: eng
  text: The exceptional energy-harvesting efficiency of lead-halide perovskites arises
    from unusually long photocarrier diffusion lengths and recombination lifetimes
    that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites
    are also known for having very short exciton decay times. Here, we resolve this
    apparent contradiction by showing that key optoelectronic properties of perovskites
    can be explained by localized flexoelectric polarization confined to interfaces
    between domains of spontaneous strain. Using birefringence imaging, electrochemical
    staining, and zero-bias photocurrent measurements, we visualize the domain structure
    and directly probe the associated internal fields in nominally cubic single crystals
    of methylammonium lead bromide. We demonstrate that localized flexoelectric fields
    spatially separate electrons and holes to opposite sides of domain walls, exponentially
    suppressing recombination. Domain walls thus act as efficient mesoscopic transport
    channels for long-lived photocarriers, microscopically linking structural heterogeneity
    to charge transport and offering mechanistically informed design principles for
    perovskite solar-energy technologies.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
acknowledgement: We are grateful to A. G. Volosniev for the valuable discussions.
  We thank D. Milius for the assistance with microscopy. D. R. would like to thank
  F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported
  by the Scientific Service Units (SSU) of ISTA through resources provided by the
  Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).
article_number: '946'
article_processing_charge: Yes
article_type: original
author:
- first_name: Dmytro
  full_name: Rak, Dmytro
  id: 70313b46-47c2-11ec-9e88-cd79101918fe
  last_name: Rak
- first_name: Dusan
  full_name: Lorenc, Dusan
  id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
  last_name: Lorenc
- first_name: Daniel
  full_name: Balazs, Daniel
  id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
  last_name: Balazs
  orcid: 0000-0001-7597-043X
- first_name: Ayan A.
  full_name: Zhumekenov, Ayan A.
  last_name: Zhumekenov
- first_name: Osman M.
  full_name: Bakr, Osman M.
  last_name: Bakr
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
citation:
  ama: Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric
    domain walls enable charge separation and transport in cubic perovskites. <i>Nature
    Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-68660-5">10.1038/s41467-026-68660-5</a>
  apa: Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., &#38; Alpichshev,
    Z. (2026). Flexoelectric domain walls enable charge separation and transport in
    cubic perovskites. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-026-68660-5">https://doi.org/10.1038/s41467-026-68660-5</a>
  chicago: Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M.
    Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation
    and Transport in Cubic Perovskites.” <i>Nature Communications</i>. Springer Nature,
    2026. <a href="https://doi.org/10.1038/s41467-026-68660-5">https://doi.org/10.1038/s41467-026-68660-5</a>.
  ieee: D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev,
    “Flexoelectric domain walls enable charge separation and transport in cubic perovskites,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric
    domain walls enable charge separation and transport in cubic perovskites. Nature
    Communications. 17, 946.
  mla: Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and
    Transport in Cubic Perovskites.” <i>Nature Communications</i>, vol. 17, 946, Springer
    Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-68660-5">10.1038/s41467-026-68660-5</a>.
  short: D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev,
    Nature Communications 17 (2026).
corr_author: '1'
date_created: 2026-03-02T10:06:58Z
date_published: 2026-02-16T00:00:00Z
date_updated: 2026-04-28T12:12:46Z
day: '16'
ddc:
- '530'
department:
- _id: ZhAl
- _id: LifeSc
doi: 10.1038/s41467-026-68660-5
external_id:
  pmid:
  - '41698893'
file:
- access_level: open_access
  checksum: dd7a98de892d0b5abefca7e290ca0f77
  content_type: application/pdf
  creator: dernst
  date_created: 2026-03-02T14:27:56Z
  date_updated: 2026-03-02T14:27:56Z
  file_id: '21390'
  file_name: 2026_NatureComm_Rak.pdf
  file_size: 2570918
  relation: main_file
  success: 1
file_date_updated: 2026-03-02T14:27:56Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/explaining-next-generation-solar-cells/
scopus_import: '1'
status: public
title: Flexoelectric domain walls enable charge separation and transport in cubic
  perovskites
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21488'
abstract:
- lang: eng
  text: Human height is a model for the genetic analysis of complex traits, and recent
    studies suggest the presence of thousands of common genetic variant associations
    and hundreds of low-frequency/rare variants. Here, we develop a new algorithmic
    paradigm based on approximate message passing (genomic vector approximate message
    passing [gVAMP]) for identifying DNA sequence variants associated with complex
    traits and common diseases in large-scale whole-genome sequencing (WGS) data.
    We show that gVAMP accurately localizes associations to variants with the correct
    frequency and position in the DNA, outperforming existing fine-mapping methods
    in selecting the appropriate genetic variants within WGS data. We then apply gVAMP
    to jointly model the relationship of tens of millions of WGS variants with human
    height in hundreds of thousands of UK Biobank individuals. We identify 59 rare
    variants and gene burden scores alongside many hundreds of DNA regions containing
    common variant associations and show that understanding the genetic basis of complex
    traits will require the joint analysis of hundreds of millions of variables measured
    on millions of people. The polygenic risk scores obtained from gVAMP have high
    accuracy (including a prediction accuracy of ∼46% for human height) and outperform
    current methods for downstream tasks such as mixed linear model association testing
    across 13 UK Biobank traits. In conclusion, gVAMP offers a scalable foundation
    for a wider range of analyses in WGS data.
acknowledgement: We thank Malgorzata Borczyk for creating the gene burden scores.
  We thank Robin Beaumont, Amedeo Roberto Esposito, Gareth Hawkes, Philip Schniter,
  Matthew Stephens, Pragya Sur, Peter Visscher, Michael Weedon, and Harry Wright for
  providing valuable suggestions and comments on earlier versions of the work. This
  project was funded by a Lopez-Loreta Prize to M.M., an SNSF Eccellenza Grant to
  M.R.R. (PCEGP3-181181), an ERC Starting Grant to M.M. (INF2, project number 101161364),
  and core funding from ISTA. High-performance computing was supported by the Scientific
  Service Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp).
  We would like to acknowledge the participants and investigators of the UK Biobank
  study. We gratefully acknowledge the All of Us participants for their contributions,
  without whom this research would not have been possible. We also thank the National
  Institutes of Health All of Us Research Program for making available the participant
  data (and/or samples and/or cohort) examined in this study.
article_number: '101162'
article_processing_charge: Yes
article_type: original
author:
- first_name: Al
  full_name: Depope, Al
  id: 0b77531d-dbcd-11ea-9d1d-a8eee0bf3830
  last_name: Depope
- first_name: Jakub
  full_name: Bajzik, Jakub
  id: b995e25b-8c4b-11ed-a6d8-f71b7bcd6122
  last_name: Bajzik
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: Depope A, Bajzik J, Mondelli M, Robinson MR. Joint modeling of whole-genome
    sequencing data for human height via approximate message passing. <i>Cell Genomics</i>.
    2026. doi:<a href="https://doi.org/10.1016/j.xgen.2026.101162">10.1016/j.xgen.2026.101162</a>
  apa: Depope, A., Bajzik, J., Mondelli, M., &#38; Robinson, M. R. (2026). Joint modeling
    of whole-genome sequencing data for human height via approximate message passing.
    <i>Cell Genomics</i>. Elsevier. <a href="https://doi.org/10.1016/j.xgen.2026.101162">https://doi.org/10.1016/j.xgen.2026.101162</a>
  chicago: Depope, Al, Jakub Bajzik, Marco Mondelli, and Matthew Richard Robinson.
    “Joint Modeling of Whole-Genome Sequencing Data for Human Height via Approximate
    Message Passing.” <i>Cell Genomics</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.xgen.2026.101162">https://doi.org/10.1016/j.xgen.2026.101162</a>.
  ieee: A. Depope, J. Bajzik, M. Mondelli, and M. R. Robinson, “Joint modeling of
    whole-genome sequencing data for human height via approximate message passing,”
    <i>Cell Genomics</i>. Elsevier, 2026.
  ista: Depope A, Bajzik J, Mondelli M, Robinson MR. 2026. Joint modeling of whole-genome
    sequencing data for human height via approximate message passing. Cell Genomics.,
    101162.
  mla: Depope, Al, et al. “Joint Modeling of Whole-Genome Sequencing Data for Human
    Height via Approximate Message Passing.” <i>Cell Genomics</i>, 101162, Elsevier,
    2026, doi:<a href="https://doi.org/10.1016/j.xgen.2026.101162">10.1016/j.xgen.2026.101162</a>.
  short: A. Depope, J. Bajzik, M. Mondelli, M.R. Robinson, Cell Genomics (2026).
corr_author: '1'
date_created: 2026-03-23T15:10:03Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-04-28T12:08:37Z
day: '18'
ddc:
- '000'
- '570'
department:
- _id: MaMo
- _id: MaRo
doi: 10.1016/j.xgen.2026.101162
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.xgen.2026.101162
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
- _id: 911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf
  grant_number: '101161364'
  name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
  grant_number: PCEGP3_181181
  name: Improving estimation and prediction of common complex disease risk
publication: Cell Genomics
publication_identifier:
  eissn:
  - 2666-979X
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/big-data-and-human-height/
status: public
title: Joint modeling of whole-genome sequencing data for human height via approximate
  message passing
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21759'
abstract:
- lang: eng
  text: 'Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences
    that bind transcription factor (TF) proteins to up- or down-regulate target genes.
    Decades-long efforts yielded TF-DNA interaction models that predict how strongly
    an individual TF binds arbitrary DNA sequences and how individual binding events
    on the CRE combine to affect gene expression. These insights can be synthesized
    into a global, biophysically realistic, and quantitative genotype-phenotype (GP)
    map for gene regulation, a ‘holy grail’ for the application of evolutionary theory.
    A global map provides a rare opportunity to simulate the long-term evolution of
    regulatory sequences and pose several fundamental questions: How long does it
    take to evolve CREs de novo? How many non-trivial regulatory functions exist in
    sequence space? How connected are they? For which regulatory architecture is CRE
    evolution most rapid and evolvable? In this article, the second of a two-part
    series, we review the application of evolutionary concepts — epistasis, robustness,
    evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene
    regulatory sequences. We then evaluate the potential for a unifying theory for
    the evolution of regulatory sequences and identify key open challenges.'
acknowledgement: "We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions
  to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship,
  jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science
  and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant
  101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European
  Molecular Biology Laboratory (N.O.B., J.C.)."
article_number: '102472'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Elia
  full_name: Mascolo, Elia
  id: 776a6ed0-a053-11f0-8635-80b95e0e0d53
  last_name: Mascolo
  orcid: 0000-0003-2977-7844
- first_name: Reka E
  full_name: Körei, Reka E
  id: 50FDE43E-AA30-11E9-A72B-8A12E6697425
  last_name: Körei
- first_name: Noa O.
  full_name: Borst, Noa O.
  last_name: Borst
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Justin
  full_name: Crocker, Justin
  last_name: Crocker
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution
    of regulatory DNA sequences. Part 2: Theory and future challenges. <i>Current
    Opinion in Genetics and Development</i>. 2026;98. doi:<a href="https://doi.org/10.1016/j.gde.2026.102472">10.1016/j.gde.2026.102472</a>'
  apa: 'Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., &#38;
    Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory
    and future challenges. <i>Current Opinion in Genetics and Development</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.gde.2026.102472">https://doi.org/10.1016/j.gde.2026.102472</a>'
  chicago: 'Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker,
    and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory
    and Future Challenges.” <i>Current Opinion in Genetics and Development</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.gde.2026.102472">https://doi.org/10.1016/j.gde.2026.102472</a>.'
  ieee: 'E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik,
    “Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,”
    <i>Current Opinion in Genetics and Development</i>, vol. 98. Elsevier, 2026.'
  ista: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term
    evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current
    Opinion in Genetics and Development. 98, 102472.'
  mla: 'Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part
    2: Theory and Future Challenges.” <i>Current Opinion in Genetics and Development</i>,
    vol. 98, 102472, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.gde.2026.102472">10.1016/j.gde.2026.102472</a>.'
  short: E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current
    Opinion in Genetics and Development 98 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-15T00:00:00Z
date_updated: 2026-04-28T12:41:00Z
day: '15'
department:
- _id: GaTk
- _id: NiBa
doi: 10.1016/j.gde.2026.102472
intvolume: '        98'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.gde.2026.102472
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
  grant_number: '101055327'
  name: Understanding the evolution of continuous genomes
publication: Current Opinion in Genetics and Development
publication_identifier:
  eissn:
  - 1879-0380
  issn:
  - 0959-437X
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Long-term evolution of regulatory DNA sequences. Part 2: Theory and future
  challenges'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21766'
abstract:
- lang: eng
  text: We provide a new characterisation of the decades old open problem of extending
    bilipschitz mappings given on a Euclidean separated net. In particular, this allows
    for the complete positive solution of the open problem in dimension two. Along
    the way, we develop a set of tools for bilipschitz extensions of mappings between
    subsets of Euclidean spaces.
acknowledgement: "The present work developed from a research visit of M.D. to V.K.
  at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant.
  This work was done while V.K. was fully funded by the Austria Science Fund (FWF)
  [M 3100-N]."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
  full_name: Dymond, Michael
  last_name: Dymond
- first_name: Vojtech
  full_name: Kaluza, Vojtech
  id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E
  last_name: Kaluza
  orcid: 0000-0002-2512-8698
citation:
  ama: Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets.
    <i>Annales Fennici Mathematici</i>. 2026;51(1):237-260. doi:<a href="https://doi.org/10.54330/afm.181562">10.54330/afm.181562</a>
  apa: Dymond, M., &#38; Kaluza, V. (2026). Extending bilipschitz mappings between
    separated nets. <i>Annales Fennici Mathematici</i>. Finnish Mathematical Society.
    <a href="https://doi.org/10.54330/afm.181562">https://doi.org/10.54330/afm.181562</a>
  chicago: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
    Separated Nets.” <i>Annales Fennici Mathematici</i>. Finnish Mathematical Society,
    2026. <a href="https://doi.org/10.54330/afm.181562">https://doi.org/10.54330/afm.181562</a>.
  ieee: M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated
    nets,” <i>Annales Fennici Mathematici</i>, vol. 51, no. 1. Finnish Mathematical
    Society, pp. 237–260, 2026.
  ista: Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated
    nets. Annales Fennici Mathematici. 51(1), 237–260.
  mla: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
    Separated Nets.” <i>Annales Fennici Mathematici</i>, vol. 51, no. 1, Finnish Mathematical
    Society, 2026, pp. 237–60, doi:<a href="https://doi.org/10.54330/afm.181562">10.54330/afm.181562</a>.
  short: M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-17T00:00:00Z
date_updated: 2026-04-28T12:06:00Z
day: '17'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.54330/afm.181562
external_id:
  arxiv:
  - '2507.22007'
file:
- access_level: open_access
  checksum: 442023926a3803d5d6ca8db8dbc4af1c
  content_type: application/pdf
  creator: dernst
  date_created: 2026-04-28T12:03:13Z
  date_updated: 2026-04-28T12:03:13Z
  file_id: '21772'
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  file_size: 342082
  relation: main_file
  success: 1
file_date_updated: 2026-04-28T12:03:13Z
has_accepted_license: '1'
intvolume: '        51'
issue: '1'
keyword:
- Lipschitz
- bilipschitz
- extension
- separated net.
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '04'
oa: 1
oa_version: Published Version
page: 237-260
project:
- _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9
  grant_number: M03100
  name: Spectra and topology of graphs and of simplicial complexes
publication: Annales Fennici Mathematici
publication_identifier:
  eissn:
  - 2737-114X
  issn:
  - 2737-0690
publication_status: published
publisher: Finnish Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extending bilipschitz mappings between separated nets
tmp:
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  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21006'
abstract:
- lang: eng
  text: Modern experimental methods in programmable self-assembly make it possible
    to precisely design particle concentrations, shapes and interactions. However,
    more physical insight is needed before we can take full advantage of this vast
    design space to assemble nanostructures with complex form and function. Here we
    show how a substantial part of this design space can be quickly and comprehensively
    understood by identifying a class of thermodynamic constraints that act on it.
    These thermodynamic constraints form a high-dimensional convex polyhedron that
    determines which nanostructures can be assembled at high equilibrium yield and
    reveals limitations that govern the coexistence of structures. We validate our
    predictions through detailed, quantitative assembly experiments of nanoscale particles
    synthesized using DNA origami. Our results uncover physical relationships underpinning
    many-component programmable self-assembly in equilibrium and form the basis for
    robust inverse design, applicable to various systems from biological protein complexes
    to synthetic nanomachines.
acknowledgement: We thank B. Isaac and A. Tiano for their technical support with the
  electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The
  TEM images were prepared and imaged at the Brandeis Electron Microscopy facility.
  This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich
  under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials
  Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846
  (T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access
  funding provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Maximilian
  full_name: Hübl, Maximilian
  id: 5eb8629e-15b2-11ec-abd3-e6f3e5e01f32
  last_name: Hübl
- first_name: Thomas E.
  full_name: Videbæk, Thomas E.
  last_name: Videbæk
- first_name: Daichi
  full_name: Hayakawa, Daichi
  last_name: Hayakawa
- first_name: W. Benjamin
  full_name: Rogers, W. Benjamin
  last_name: Rogers
- first_name: Carl Peter
  full_name: Goodrich, Carl Peter
  id: EB352CD2-F68A-11E9-89C5-A432E6697425
  last_name: Goodrich
  orcid: 0000-0002-1307-5074
citation:
  ama: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure
    controls programmable self-assembly. <i>Nature Physics</i>. 2026. doi:<a href="https://doi.org/10.1038/s41567-025-03120-3">10.1038/s41567-025-03120-3</a>
  apa: Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., &#38; Goodrich, C. P.
    (2026). A polyhedral structure controls programmable self-assembly. <i>Nature
    Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-025-03120-3">https://doi.org/10.1038/s41567-025-03120-3</a>
  chicago: Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers,
    and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.”
    <i>Nature Physics</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41567-025-03120-3">https://doi.org/10.1038/s41567-025-03120-3</a>.
  ieee: M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A
    polyhedral structure controls programmable self-assembly,” <i>Nature Physics</i>.
    Springer Nature, 2026.
  ista: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral
    structure controls programmable self-assembly. Nature Physics.
  mla: Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.”
    <i>Nature Physics</i>, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41567-025-03120-3">10.1038/s41567-025-03120-3</a>.
  short: M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics
    (2026).
corr_author: '1'
date_created: 2026-01-20T10:02:19Z
date_published: 2026-01-08T00:00:00Z
date_updated: 2026-04-28T11:56:45Z
day: '08'
ddc:
- '570'
- '540'
department:
- _id: CaGo
- _id: GradSch
doi: 10.1038/s41567-025-03120-3
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41567-025-03120-3
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 8dd93da8-16d5-11f0-9cad-d2c70200d9a5
  grant_number: FTI23-G-011
  name: Dynamically reconfigurable self-assembly with triangular DNA-origami bricks
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/behind-natures-blueprints/
scopus_import: '1'
status: public
title: A polyhedral structure controls programmable self-assembly
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21760'
abstract:
- lang: eng
  text: 3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua
    and 2I/Borisov. Its unusually high excess velocity and active cometary nature
    make it a key probe of the Galactic population of icy planetesimals. Understanding
    its origin requires its past trajectory through the Galaxy to be traced and the
    possible role of stellar encounters to be assessed, both as a potential origin
    and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in
    time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry
    and radial velocities, to identify close passages within 2 pc. We identify 93
    nominal encounters, 62 of which are significant at the 2σ level. However, none
    of these encounters produced any meaningful perturbation. The strongest perturber
    Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km
    s−1, imparted only a velocity change of ∣Δv∣  ≃  5  ×  10−4 km s−1 to the orbit
    of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr
    and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS
    or be associated with its origin. We further show that 3I/ATLAS is kinematically
    consistent with a thin-disk population, despite its large peculiar velocity.
acknowledgement: We thank the anonymous referee for a careful reading of the manuscript
  and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L.
  Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges
  financial support from the Spanish National Programme for the Promotion of Talent
  and its Employability grant PRE2022-104959 cofunded by the European Social Fund.
  S.T. acknowledges the funding from the European Union’s Horizon 2020 research and
  innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413.
  E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio
  de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M.
  acknowledges support from the Swedish National Space Agency (Career grant 2023-00146).
  X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn
  y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from
  the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref.
  ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use
  of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia
  Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided
  by national institutions, particularly the institutions participating in the Gaia
  Multilateral Agreement.
article_number: '146'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: X.
  full_name: Pérez-Couto, X.
  last_name: Pérez-Couto
- first_name: Santiago
  full_name: Torres Rodriguez, Santiago
  id: a8df4360-4328-11ee-8f1a-e502d0c83fc2
  last_name: Torres Rodriguez
  orcid: 0000-0002-3150-8988
- first_name: E.
  full_name: Villaver, E.
  last_name: Villaver
- first_name: A. J.
  full_name: Mustill, A. J.
  last_name: Mustill
- first_name: M.
  full_name: Manteiga, M.
  last_name: Manteiga
citation:
  ama: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS:
    In search of the witnesses to its voyage. <i>The Astrophysical Journal</i>. 2026;1001(2).
    doi:<a href="https://doi.org/10.3847/1538-4357/ae56ff">10.3847/1538-4357/ae56ff</a>'
  apa: 'Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., &#38;
    Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. <i>The
    Astrophysical Journal</i>. IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ae56ff">https://doi.org/10.3847/1538-4357/ae56ff</a>'
  chicago: 'Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill,
    and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” <i>The
    Astrophysical Journal</i>. IOP Publishing, 2026. <a href="https://doi.org/10.3847/1538-4357/ae56ff">https://doi.org/10.3847/1538-4357/ae56ff</a>.'
  ieee: 'X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga,
    “3I/ATLAS: In search of the witnesses to its voyage,” <i>The Astrophysical Journal</i>,
    vol. 1001, no. 2. IOP Publishing, 2026.'
  ista: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026.
    3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal.
    1001(2), 146.'
  mla: 'Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.”
    <i>The Astrophysical Journal</i>, vol. 1001, no. 2, 146, IOP Publishing, 2026,
    doi:<a href="https://doi.org/10.3847/1538-4357/ae56ff">10.3847/1538-4357/ae56ff</a>.'
  short: X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga,
    The Astrophysical Journal 1001 (2026).
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:08:39Z
day: '20'
ddc:
- '520'
department:
- _id: LiBu
doi: 10.3847/1538-4357/ae56ff
ec_funded: 1
external_id:
  arxiv:
  - '2509.07678'
file:
- access_level: open_access
  checksum: c3daf49261a9933c079854c38eec316f
  content_type: application/pdf
  creator: dernst
  date_created: 2026-04-28T13:06:00Z
  date_updated: 2026-04-28T13:06:00Z
  file_id: '21773'
  file_name: 2026_AstrophysicalJournal_PerezCouto.pdf
  file_size: 2905627
  relation: main_file
  success: 1
file_date_updated: 2026-04-28T13:06:00Z
has_accepted_license: '1'
intvolume: '      1001'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: '3I/ATLAS: In search of the witnesses to its voyage'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1001
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21761'
abstract:
- lang: eng
  text: Neural tube closure is a critical morphogenetic process in vertebrate development,
    and failure to close cranial regions such as the hindbrain neuropore (HNP) leads
    to severe congenital malformations. While mechanical forces such as actomyosin
    purse-string contraction and directional cell crawling have been implicated in
    driving HNP closure, how these forces organize local cell shape and motion to
    produce large-scale tissue remodeling remains poorly understood. Using live and
    fixed imaging of mouse embryos combined with cell-based biophysical modeling,
    we show that these force-generating mechanisms are insufficient to explain the
    reproducible patterns of cell elongation and nematic alignment observed at the
    HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization
    are required to generate these patterns and promote midline cell motion. Our model
    captures key features of cell shape dynamics and emergent nematic order, which
    we confirm experimentally, including the alignment of actin fibers with cell shape
    and enhanced midline cell speed. Comparative analysis with chick embryos, which
    lack supracellular purse strings, supports a conserved link between tension generation
    and cellular patterning. These findings establish a physical framework connecting
    force generation, cell shape anisotropy, and tissue morphodynamics during epithelial
    gap closure.
acknowledgement: S.B. acknowledges support from the National Institutes of Health
  (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G.
  acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society
  (RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support
  from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028.
  F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction
  macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Fernanda L
  full_name: Perez Verdugo, Fernanda L
  id: 4ecec223-9070-11ef-a0a9-bc76077bea8d
  last_name: Perez Verdugo
- first_name: Eirini
  full_name: Maniou, Eirini
  last_name: Maniou
- first_name: Gabriel L.
  full_name: Galea, Gabriel L.
  last_name: Galea
- first_name: Shiladitya
  full_name: Banerjee, Shiladitya
  last_name: Banerjee
citation:
  ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback
    organizes cell shape and motion during hindbrain neuropore morphogenesis. <i>Current
    Biology</i>. 2026;36(8):1903-1917.e5. doi:<a href="https://doi.org/10.1016/j.cub.2026.02.068">10.1016/j.cub.2026.02.068</a>
  apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., &#38; Banerjee, S. (2026).
    Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore
    morphogenesis. <i>Current Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.cub.2026.02.068">https://doi.org/10.1016/j.cub.2026.02.068</a>
  chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya
    Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain
    Neuropore Morphogenesis.” <i>Current Biology</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.cub.2026.02.068">https://doi.org/10.1016/j.cub.2026.02.068</a>.
  ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive
    feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,”
    <i>Current Biology</i>, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.
  ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback
    organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
    Biology. 36(8), 1903–1917.e5.
  mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell
    Shape and Motion during Hindbrain Neuropore Morphogenesis.” <i>Current Biology</i>,
    vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:<a href="https://doi.org/10.1016/j.cub.2026.02.068">10.1016/j.cub.2026.02.068</a>.
  short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36
    (2026) 1903–1917.e5.
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:15:42Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.cub.2026.02.068
external_id:
  pmid:
  - '41881011'
file:
- access_level: open_access
  checksum: 80ae45457b4682c50c84f54de15aa9a8
  content_type: application/pdf
  creator: dernst
  date_created: 2026-04-28T13:13:40Z
  date_updated: 2026-04-28T13:13:40Z
  file_id: '21774'
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  file_size: 13402043
  relation: main_file
  success: 1
file_date_updated: 2026-04-28T13:13:40Z
has_accepted_license: '1'
intvolume: '        36'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1903-1917.e5
pmid: 1
publication: Current Biology
publication_identifier:
  eissn:
  - 1879-0445
  issn:
  - 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanosensitive feedback organizes cell shape and motion during hindbrain
  neuropore morphogenesis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_type: closed access
_id: '21762'
abstract:
- lang: eng
  text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
    organization. The plasmid-encoded ParMRC system forms actin-like filaments that
    segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
    sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
    system named CorMR with a function in cell shape control rather than DNA segregation.
    Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
    that CorM formed dynamically unstable, antiparallel double-stranded filaments
    that were recruited to the membrane by CorR through an amphipathic helix conserved
    in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
    excluded them from the poles and division plane. Comparative genomics indicated
    that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
    highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
  M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
  for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
  strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
  strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
  the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
  screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
  collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
  was supported by the Scientific Service Units (SSU) of ISTA through resources provided
  by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
  Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
  was funded by the European Union’s Horizon 2020 research and innovation program
  (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
  (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
  Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
  et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
  full_name: Springstein, Benjamin L
  id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
  last_name: Springstein
  orcid: 0000-0002-3461-5391
- first_name: Manjunath
  full_name: Javoor, Manjunath
  id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
  last_name: Javoor
  orcid: 0000-0003-2311-2112
- first_name: Daniela
  full_name: Megrian, Daniela
  last_name: Megrian
- first_name: Roman
  full_name: Hajdu, Roman
  id: ffab949d-133f-11ed-8f02-94de21ace503
  last_name: Hajdu
- first_name: Dustin M.
  full_name: Hanke, Dustin M.
  last_name: Hanke
- first_name: Bettina
  full_name: Zens, Bettina
  id: 45FD126C-F248-11E8-B48F-1D18A9856A87
  last_name: Zens
  orcid: 0000-0002-9561-1239
- first_name: Gregor L.
  full_name: Weiss, Gregor L.
  last_name: Weiss
- first_name: Florian Km
  full_name: Schur, Florian Km
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
    machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795).
    doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>
  apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
    B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. <i>Science</i>. AAAS. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>
  chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
    Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
    “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
    Cell Shape.” <i>Science</i>. AAAS, 2026. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>.
  ieee: B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery
    into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392,
    no. 6795. AAAS, 2026.
  ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
    Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. Science. 392(6795), eaea6343.
  mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
    into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392,
    no. 6795, eaea6343, AAAS, 2026, doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>.
  short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
    Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-04-28T13:29:05Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
  pmid:
  - '41990175'
intvolume: '       392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
  grant_number: '101076260'
  name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
  cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21755'
abstract:
- lang: eng
  text: Tropical shallow clouds are a major source of uncertainty in Earth's climate
    sensitivity, especially through their spatial arrangement, which global climate
    models do not represent. Efforts to understand their organization have partly
    relied on classifying observed scenes, identifying four patterns as archetypal
    regimes. Here we analyze geostationary satellite imagery of the western tropical
    Atlantic using the L‐function, a tool based on point pattern theory that quantifies
    cloud organization across spatial scales. Classical examples of the four patterns
    show distinct L‐function fingerprints, revealing their characteristic clustering
    and regularity scales and aiding physical interpretation. Yet, when evaluating
    many scenes at fixed spatial scales, the L‐function distribution lacks the distinct
    modes expected from discrete regimes. This is corroborated by analyses of other
    organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor
    distances to fractal analysis. Implications for the parameterization of mesoscale
    cloud organization in climate models are discussed.
acknowledgement: GB was supported by an ICTP Postdoctoral Research Fellowship Agreement.
  GM was supported by the CNRS. AC was supported by the European Union's Horizon 2020
  research and innovation programme Marie Sklodowska-Curie Grant agreement No 101034413.
  LJF acknowledges funding from the NERC Doctoral Training Partnership in Environmental
  Research Grant NE/S007474/1. We thank three anonymous reviewers and Jiawei Bao for
  their insightful comments, which greatly improved this manuscript.
article_number: e2025GL119921
article_processing_charge: Yes
article_type: original
author:
- first_name: Giovanni
  full_name: Biagioli, Giovanni
  last_name: Biagioli
- first_name: Giulio
  full_name: Mandorli, Giulio
  last_name: Mandorli
- first_name: Lilli Johanna
  full_name: Freischem, Lilli Johanna
  last_name: Freischem
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Adrian Mark
  full_name: Tompkins, Adrian Mark
  last_name: Tompkins
citation:
  ama: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. Spatial
    patterns of shallow clouds: Challenging the concept of defined regimes. <i>Geophysical
    Research Letters</i>. 2026;53(8). doi:<a href="https://doi.org/10.1029/2025gl119921">10.1029/2025gl119921</a>'
  apa: 'Biagioli, G., Mandorli, G., Freischem, L. J., Casallas Garcia, A., &#38; Tompkins,
    A. M. (2026). Spatial patterns of shallow clouds: Challenging the concept of defined
    regimes. <i>Geophysical Research Letters</i>. Wiley. <a href="https://doi.org/10.1029/2025gl119921">https://doi.org/10.1029/2025gl119921</a>'
  chicago: 'Biagioli, Giovanni, Giulio Mandorli, Lilli Johanna Freischem, Alejandro
    Casallas Garcia, and Adrian Mark Tompkins. “Spatial Patterns of Shallow Clouds:
    Challenging the Concept of Defined Regimes.” <i>Geophysical Research Letters</i>.
    Wiley, 2026. <a href="https://doi.org/10.1029/2025gl119921">https://doi.org/10.1029/2025gl119921</a>.'
  ieee: 'G. Biagioli, G. Mandorli, L. J. Freischem, A. Casallas Garcia, and A. M.
    Tompkins, “Spatial patterns of shallow clouds: Challenging the concept of defined
    regimes,” <i>Geophysical Research Letters</i>, vol. 53, no. 8. Wiley, 2026.'
  ista: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. 2026.
    Spatial patterns of shallow clouds: Challenging the concept of defined regimes.
    Geophysical Research Letters. 53(8), e2025GL119921.'
  mla: 'Biagioli, Giovanni, et al. “Spatial Patterns of Shallow Clouds: Challenging
    the Concept of Defined Regimes.” <i>Geophysical Research Letters</i>, vol. 53,
    no. 8, e2025GL119921, Wiley, 2026, doi:<a href="https://doi.org/10.1029/2025gl119921">10.1029/2025gl119921</a>.'
  short: G. Biagioli, G. Mandorli, L.J. Freischem, A. Casallas Garcia, A.M. Tompkins,
    Geophysical Research Letters 53 (2026).
date_created: 2026-04-21T06:04:41Z
date_published: 2026-04-28T00:00:00Z
date_updated: 2026-04-28T13:35:53Z
day: '28'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2025gl119921
ec_funded: 1
file:
- access_level: open_access
  checksum: 2cd4ae120b14b244f5b2f50eaae0efc1
  content_type: application/pdf
  creator: acasalla
  date_created: 2026-04-21T06:07:22Z
  date_updated: 2026-04-21T06:07:22Z
  file_id: '21756'
  file_name: Gio_Casallas_2026.pdf
  file_size: 1544417
  relation: main_file
  success: 1
file_date_updated: 2026-04-21T06:07:22Z
has_accepted_license: '1'
intvolume: '        53'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Geophysical Research Letters
publication_identifier:
  eissn:
  - 1944-8007
  issn:
  - 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spatial patterns of shallow clouds: Challenging the concept of defined regimes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21752'
abstract:
- lang: eng
  text: Epithelial tissues function as multicellular communities that preserve tissue
    integrity while adapting to diverse environmental stresses by altering cell behaviors.
    A striking manifestation of such adaptability is cell plasticity, the ability
    of differentiated cells to revert to stem-like states or adopt alternative fates.
    Once considered rare and confined to highly regenerative species, cell plasticity
    is now recognized across the metazoan tree. In early-branching animals such as
    sponges and cnidarians, transdifferentiation and dedifferentiation are integral
    to life-cycle transitions and regeneration, whereas in more complex organisms,
    these processes typically emerge under stress, including stem cell loss or environmental
    perturbations. Here, we examine epithelial cell plasticity through evolutionary,
    cellular, and molecular perspectives. Focusing on the intestinal epithelium, we
    explore findings from mammalian and Drosophila models showing that progenitors
    and even terminally differentiated cells can dedifferentiate in response to external
    stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations.
    We further discuss conserved mechanisms involving intercellular signaling (e.g.,
    Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated
    by metabolic cues. Together, these insights position cell plasticity as an ancient
    environmental adaptation strategy, shaped by conserved molecular toolkits and
    refined by species- and cell lineage-specific innovations.
acknowledgement: This work was supported by JSPS/MEXT KAKENHI (grant numbers JP22J01430
  to H.N., JP23H04696, JP23K24025, JP25H02543, JP25K02406 to Y.N.), JST FOREST Program
  JPMJFR233E (Y.N.), The Cell Science Research Foundation (Y.N.), and Takeda Science
  Foundation (Y.N.).
article_number: '103670'
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Hiroki
  full_name: Nagai, Hiroki
  id: 608df3e6-e2ab-11ed-8890-c9318cec7da4
  last_name: Nagai
  orcid: 0000-0003-1671-9434
- first_name: Yu Ichiro
  full_name: Nakajima, Yu Ichiro
  last_name: Nakajima
citation:
  ama: 'NAGAI H, Nakajima YI. Epithelial cell plasticity in metazoans: Evolutionary
    insights into roles and mechanisms. <i>Seminars in Cell and Developmental Biology</i>.
    2026;179-180. doi:<a href="https://doi.org/10.1016/j.semcdb.2026.103670">10.1016/j.semcdb.2026.103670</a>'
  apa: 'NAGAI, H., &#38; Nakajima, Y. I. (2026). Epithelial cell plasticity in metazoans:
    Evolutionary insights into roles and mechanisms. <i>Seminars in Cell and Developmental
    Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.semcdb.2026.103670">https://doi.org/10.1016/j.semcdb.2026.103670</a>'
  chicago: 'NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in
    Metazoans: Evolutionary Insights into Roles and Mechanisms.” <i>Seminars in Cell
    and Developmental Biology</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.semcdb.2026.103670">https://doi.org/10.1016/j.semcdb.2026.103670</a>.'
  ieee: 'H. NAGAI and Y. I. Nakajima, “Epithelial cell plasticity in metazoans: Evolutionary
    insights into roles and mechanisms,” <i>Seminars in Cell and Developmental Biology</i>,
    vol. 179–180. Elsevier, 2026.'
  ista: 'NAGAI H, Nakajima YI. 2026. Epithelial cell plasticity in metazoans: Evolutionary
    insights into roles and mechanisms. Seminars in Cell and Developmental Biology.
    179–180, 103670.'
  mla: 'NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans:
    Evolutionary Insights into Roles and Mechanisms.” <i>Seminars in Cell and Developmental
    Biology</i>, vol. 179–180, 103670, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.semcdb.2026.103670">10.1016/j.semcdb.2026.103670</a>.'
  short: H. NAGAI, Y.I. Nakajima, Seminars in Cell and Developmental Biology 179–180
    (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:49Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-04-28T14:11:13Z
day: '01'
ddc:
- '570'
department:
- _id: XiFe
doi: 10.1016/j.semcdb.2026.103670
file:
- access_level: open_access
  checksum: 0a0929a045d0cbd964297768833c14ae
  content_type: application/pdf
  creator: dernst
  date_created: 2026-04-28T13:58:47Z
  date_updated: 2026-04-28T13:58:47Z
  file_id: '21775'
  file_name: 2026_SeminarsCellDevBiology_Nagai.pdf
  file_size: 1306613
  relation: main_file
  success: 1
file_date_updated: 2026-04-28T13:58:47Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: Seminars in Cell and Developmental Biology
publication_identifier:
  eissn:
  - 1096-3634
  issn:
  - 1084-9521
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Epithelial cell plasticity in metazoans: Evolutionary insights into roles
  and mechanisms'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 179-180
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '14278'
abstract:
- lang: eng
  text: 'The Birkhoff conjecture says that the boundary of a strictly convex integrable
    billiard table is necessarily an ellipse. In this article, we consider a stronger
    notion of integrability, namely, integrability close to the boundary, and prove
    a local version of this conjecture: a small perturbation of almost every ellipse
    that preserves integrability near the boundary, is itself an ellipse. We apply
    this result to study local spectral uniqueness of ellipses using the connection
    between the wave trace of the Laplacian and the dynamics near the boundary and
    establish local uniqueness for almost all of them.'
acknowledgement: 'The author acknowledges the partial support of the European Research
  Council Grant #885707. He also thanks Vadim Kaloshin for proposing the idea of the
  project and greatly aiding the implementation. The author is also grateful to Hamid
  Hezari, Amir Vig, Steve Zelditch, Comlan E. Koudjinan, Corentin Fierobe, Ngo Nhok
  Tkhai Shon and Roman Sarapin for useful discussions. The author also acknowledges
  partial support of ISTern summer program. The project started in the summer of 2021,
  when the author was an intern at ISTA. Open access funding provided by Institute
  of Science and Technology (IST Austria).'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Illya
  full_name: Koval, Illya
  id: 2eed1f3b-896a-11ed-bdf8-93c7c4bf159e
  last_name: Koval
citation:
  ama: Koval I. Local strong Birkhoff conjecture and local spectral rigidity of almost
    every ellipse. <i>Inventiones Mathematicae</i>. 2025. doi:<a href="https://doi.org/10.1007/s00222-025-01397-y">10.1007/s00222-025-01397-y</a>
  apa: Koval, I. (2025). Local strong Birkhoff conjecture and local spectral rigidity
    of almost every ellipse. <i>Inventiones Mathematicae</i>. Springer Nature. <a
    href="https://doi.org/10.1007/s00222-025-01397-y">https://doi.org/10.1007/s00222-025-01397-y</a>
  chicago: Koval, Illya. “Local Strong Birkhoff Conjecture and Local Spectral Rigidity
    of Almost Every Ellipse.” <i>Inventiones Mathematicae</i>. Springer Nature, 2025.
    <a href="https://doi.org/10.1007/s00222-025-01397-y">https://doi.org/10.1007/s00222-025-01397-y</a>.
  ieee: I. Koval, “Local strong Birkhoff conjecture and local spectral rigidity of
    almost every ellipse,” <i>Inventiones Mathematicae</i>. Springer Nature, 2025.
  ista: Koval I. 2025. Local strong Birkhoff conjecture and local spectral rigidity
    of almost every ellipse. Inventiones Mathematicae.
  mla: Koval, Illya. “Local Strong Birkhoff Conjecture and Local Spectral Rigidity
    of Almost Every Ellipse.” <i>Inventiones Mathematicae</i>, Springer Nature, 2025,
    doi:<a href="https://doi.org/10.1007/s00222-025-01397-y">10.1007/s00222-025-01397-y</a>.
  short: I. Koval, Inventiones Mathematicae (2025).
corr_author: '1'
date_created: 2023-09-06T08:35:43Z
date_published: 2025-12-11T00:00:00Z
date_updated: 2025-12-29T11:37:48Z
day: '11'
ddc:
- '510'
department:
- _id: GradSch
- _id: VaKa
doi: 10.1007/s00222-025-01397-y
ec_funded: 1
external_id:
  arxiv:
  - '2111.12171'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s00222-025-01397-y
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 9B8B92DE-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '885707'
  name: Spectral rigidity and integrability for billiards and geodesic flows
publication: Inventiones Mathematicae
publication_identifier:
  eissn:
  - 1432-1297
  issn:
  - 0020-9910
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Local strong Birkhoff conjecture and local spectral rigidity of almost every
  ellipse
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '14647'
abstract:
- lang: eng
  text: "In the developing vertebrate central nervous system, neurons and glia typically
    arise\r\nsequentially from common progenitors. Here, we report that the transcription
    factor Forkhead\r\nBox G1 (Foxg1) regulates gliogenesis in the mouse neocortex
    via distinct cell-autonomous roles in progenitors and postmitotic neurons that
    regulate different aspects of the gliogenic FGF signalling pathway. We demonstrate
    that loss of Foxg1 in cortical progenitors at neurogenic stages causes premature
    astrogliogenesis. We identify a novel FOXG1 target, the pro-gliogenic FGF pathway
    component Fgfr3, which is suppressed by FOXG1 cell-autonomously to maintain neurogenesis.
    Furthermore, FOXG1 can also suppress premature astrogliogenesis triggered by the
    augmentation of FGF signalling. We identify a second novel function of FOXG1 in
    regulating the expression of gliogenic cues in newborn neocortical upper-layer
    neurons. Loss of FOXG1 in postmitotic neurons non-autonomously enhances gliogenesis
    in the progenitors via FGF signalling. These results fit well with the model that
    newborn neurons secrete cues that trigger progenitors to produce the next wave
    of cell types, astrocytes. If FGF signalling is attenuated in Foxg1 null progenitors,
    they progress to oligodendrocyte production. Therefore, loss of FOXG1 transitions
    the progenitor to a gliogenic state, producing either astrocytes or oligodendrocytes
    depending on FGF signalling levels. Our results uncover how FOXG1 integrates extrinsic
    signalling via the FGF pathway to regulate the sequential generation of neurons,
    astrocytes, and oligodendrocytes in the cerebral cortex. "
acknowledgement: "We thank the animal house staff of the Tata Institute of Fundamental
  Research, Mumbai (TIFR), for their excellent support; Gordon Fishell (Harvard Medical
  School, USA), and Goichi Miyoshi (Gunma University, Japan) for the Foxg1 floxed
  mouse line; Hiroshi Kawasaki (Kanazawa University, Japan) for the plasmids pCAG-FGF8
  and pCAG-sFgfr3c; Soo Kyung Lee (University at Buffalo, The State University of
  New York, USA) for the Foxg1lox/lox genotyping primers and protocol. We thank Deepak
  Modi and Vainav Patel (National Institute for Research in Reproductive and Child
  Health, NIRRCH, Mumbai, India) for the use of the NIRRCH FACS Facility, and the
  staff of the NIRRCH and TIFR FACS facilities for their assistance. We thank Denis
  Jabaudon (University of Geneva, Switzerland) for his critical comments on the manuscript
  and members of the Jabaudon lab for helpful discussions. This work was funded by
  the Department of Atomic Energy (DAE), Govt. of India (Project Identification no.
  RTI4003,\r\nDAE OM no. 1303/2/2019/R&D-II/DAE/2079). "
article_number: '101851'
article_processing_charge: Yes
article_type: original
author:
- first_name: Mahima
  full_name: Bose, Mahima
  last_name: Bose
- first_name: Varun
  full_name: Suresh, Varun
  last_name: Suresh
- first_name: Urvi
  full_name: Mishra, Urvi
  last_name: Mishra
- first_name: Ishita
  full_name: Talwar, Ishita
  last_name: Talwar
- first_name: Anuradha
  full_name: Yadav, Anuradha
  last_name: Yadav
- first_name: Shiona
  full_name: Biswas, Shiona
  last_name: Biswas
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Shubha
  full_name: Tole, Shubha
  last_name: Tole
citation:
  ama: Bose M, Suresh V, Mishra U, et al. Dual role of FOXG1 in regulating gliogenesis
    in the developing neocortex via the FGF signalling pathway. <i>eLife</i>. 2025;13.
    doi:<a href="https://doi.org/10.7554/elife.101851.3">10.7554/elife.101851.3</a>
  apa: Bose, M., Suresh, V., Mishra, U., Talwar, I., Yadav, A., Biswas, S., … Tole,
    S. (2025). Dual role of FOXG1 in regulating gliogenesis in the developing neocortex
    via the FGF signalling pathway. <i>ELife</i>. eLife Sciences Publications. <a
    href="https://doi.org/10.7554/elife.101851.3">https://doi.org/10.7554/elife.101851.3</a>
  chicago: Bose, Mahima, Varun Suresh, Urvi Mishra, Ishita Talwar, Anuradha Yadav,
    Shiona Biswas, Simon Hippenmeyer, and Shubha Tole. “Dual Role of FOXG1 in Regulating
    Gliogenesis in the Developing Neocortex via the FGF Signalling Pathway.” <i>ELife</i>.
    eLife Sciences Publications, 2025. <a href="https://doi.org/10.7554/elife.101851.3">https://doi.org/10.7554/elife.101851.3</a>.
  ieee: M. Bose <i>et al.</i>, “Dual role of FOXG1 in regulating gliogenesis in the
    developing neocortex via the FGF signalling pathway,” <i>eLife</i>, vol. 13. eLife
    Sciences Publications, 2025.
  ista: Bose M, Suresh V, Mishra U, Talwar I, Yadav A, Biswas S, Hippenmeyer S, Tole
    S. 2025. Dual role of FOXG1 in regulating gliogenesis in the developing neocortex
    via the FGF signalling pathway. eLife. 13, 101851.
  mla: Bose, Mahima, et al. “Dual Role of FOXG1 in Regulating Gliogenesis in the Developing
    Neocortex via the FGF Signalling Pathway.” <i>ELife</i>, vol. 13, 101851, eLife
    Sciences Publications, 2025, doi:<a href="https://doi.org/10.7554/elife.101851.3">10.7554/elife.101851.3</a>.
  short: M. Bose, V. Suresh, U. Mishra, I. Talwar, A. Yadav, S. Biswas, S. Hippenmeyer,
    S. Tole, ELife 13 (2025).
date_created: 2023-12-06T13:07:01Z
date_published: 2025-03-14T00:00:00Z
date_updated: 2025-05-14T11:41:52Z
day: '14'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.7554/elife.101851.3
external_id:
  pmid:
  - '40085500'
file:
- access_level: open_access
  checksum: 64a6a6f86e24b21fe72c7a7fd6056fed
  content_type: application/pdf
  creator: dernst
  date_created: 2025-04-03T11:19:26Z
  date_updated: 2025-04-03T11:19:26Z
  file_id: '19467'
  file_name: 2025_eLife_Bose.pdf
  file_size: 17462771
  relation: main_file
  success: 1
file_date_updated: 2025-04-03T11:19:26Z
has_accepted_license: '1'
intvolume: '        13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via
  the FGF signalling pathway
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '18074'
abstract:
- lang: eng
  text: The Aharonov–Casher theorem is a result on the number of the so-called zero
    modes of a system described by the magnetic Pauli operator in R2. In this paper
    we address the same question for the Dirac operator on a flat two-dimensional
    manifold with boundary and Atiyah–Patodi–Singer boundary condition. More concretely
    we are interested in the plane and a disc with a finite number of circular holes
    cut out. We consider a smooth compactly supported magnetic field on the manifold
    and an arbitrary magnetic field inside the holes.
acknowledgement: "First and foremost I am grateful to Jan Philip Solovej for fruitful
  meetings during (and after) my PhD programme, when this work was done. Further I
  would like to thank Joshua Hunt, Anna Sisak, Jakub Löwit, Błażej Ruba, Volodymir
  Riabov, Lukas Schimmer and Georgios Koutentakis for valuable discussions. Many thanks
  belong to Rafael Benguria for hosting my visit, during which some of the work has
  been done. I am also grateful to Marina Prokhorova who first initiated the discussion
  of this project topic and to Annemarie Luger for her valuable comments during my
  PhD defence and in particular pointing out the qualitative difference in our two
  main results. I would like to acknowledge support for research on this paper from
  VILLUM FONDEN through the QMATH Centre of Excellence grant. nr. 10059. This project
  also received funding from the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant agreement No 101034413. I am grateful
  to the two reviewers for reading carefully my manuscript and pointing out several
  issues contributing thus significantly to the readability and clarity of this paper.\r\nOpen
  access funding provided by Institute of Science and Technology (IST Austria)."
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Marie
  full_name: Fialova, Marie
  id: e9c9844d-9e21-11ec-b482-f96fc09f7c4d
  last_name: Fialova
citation:
  ama: Fialova M. Aharonov–Casher theorems for Dirac operators on manifolds with boundary
    and APS boundary condition. <i>Annales Henri Poincare</i>. 2025;26:2859-2900.
    doi:<a href="https://doi.org/10.1007/s00023-024-01482-7">10.1007/s00023-024-01482-7</a>
  apa: Fialova, M. (2025). Aharonov–Casher theorems for Dirac operators on manifolds
    with boundary and APS boundary condition. <i>Annales Henri Poincare</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s00023-024-01482-7">https://doi.org/10.1007/s00023-024-01482-7</a>
  chicago: Fialova, Marie. “Aharonov–Casher Theorems for Dirac Operators on Manifolds
    with Boundary and APS Boundary Condition.” <i>Annales Henri Poincare</i>. Springer
    Nature, 2025. <a href="https://doi.org/10.1007/s00023-024-01482-7">https://doi.org/10.1007/s00023-024-01482-7</a>.
  ieee: M. Fialova, “Aharonov–Casher theorems for Dirac operators on manifolds with
    boundary and APS boundary condition,” <i>Annales Henri Poincare</i>, vol. 26.
    Springer Nature, pp. 2859–2900, 2025.
  ista: Fialova M. 2025. Aharonov–Casher theorems for Dirac operators on manifolds
    with boundary and APS boundary condition. Annales Henri Poincare. 26, 2859–2900.
  mla: Fialova, Marie. “Aharonov–Casher Theorems for Dirac Operators on Manifolds
    with Boundary and APS Boundary Condition.” <i>Annales Henri Poincare</i>, vol.
    26, Springer Nature, 2025, pp. 2859–900, doi:<a href="https://doi.org/10.1007/s00023-024-01482-7">10.1007/s00023-024-01482-7</a>.
  short: M. Fialova, Annales Henri Poincare 26 (2025) 2859–2900.
corr_author: '1'
date_created: 2024-09-15T22:01:42Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-09-30T10:22:14Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s00023-024-01482-7
ec_funded: 1
external_id:
  arxiv:
  - '2304.13373'
  isi:
  - '001304370000001'
file:
- access_level: open_access
  checksum: d8d2d6dbce293c9ee6eaa9262e597147
  content_type: application/pdf
  creator: dernst
  date_created: 2025-08-05T11:24:25Z
  date_updated: 2025-08-05T11:24:25Z
  file_id: '20124'
  file_name: 2025_AnnalesHenriPoincare_Fialova.pdf
  file_size: 728124
  relation: main_file
  success: 1
file_date_updated: 2025-08-05T11:24:25Z
has_accepted_license: '1'
intvolume: '        26'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 2859-2900
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Annales Henri Poincare
publication_identifier:
  issn:
  - 1424-0637
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Aharonov–Casher theorems for Dirac operators on manifolds with boundary and
  APS boundary condition
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 26
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18154'
abstract:
- lang: eng
  text: 'In 1976, Deligne and Lusztig realized the representation theory of finite
    groups of Lie type inside étale cohomology of certain algebraic varieties. Recently,
    a p-adic version of this theory started to emerge: there are p-adic Deligne–Lusztig
    spaces, whose cohomology encodes representation theoretic information for p-adic
    groups – for instance, it partially realizes the local Langlands correspondence
    with characteristic zero coefficients. However, the parallel case of coefficients
    of positive characteristic  ℓ≠p has not been inspected so far. The purpose of
    this article is to initiate such an inspection. In particular, we relate cohomology
    of certain p-adic Deligne–Lusztig spaces to Vignéras''s modular local Langlands
    correspondence for GLn.'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. On modulo ℓ cohomology of p-adic Deligne–Lusztig varieties for GLn.
    <i>Journal of Algebra</i>. 2025;663(2):81-118. doi:<a href="https://doi.org/10.1016/j.jalgebra.2024.08.033">10.1016/j.jalgebra.2024.08.033</a>
  apa: Löwit, J. (2025). On modulo ℓ cohomology of p-adic Deligne–Lusztig varieties
    for GLn. <i>Journal of Algebra</i>. Elsevier. <a href="https://doi.org/10.1016/j.jalgebra.2024.08.033">https://doi.org/10.1016/j.jalgebra.2024.08.033</a>
  chicago: Löwit, Jakub. “On modulo ℓ Cohomology of P-Adic Deligne–Lusztig Varieties
    for GLn.” <i>Journal of Algebra</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.jalgebra.2024.08.033">https://doi.org/10.1016/j.jalgebra.2024.08.033</a>.
  ieee: J. Löwit, “On modulo ℓ cohomology of p-adic Deligne–Lusztig varieties for
    GLn,” <i>Journal of Algebra</i>, vol. 663, no. 2. Elsevier, pp. 81–118, 2025.
  ista: Löwit J. 2025. On modulo ℓ cohomology of p-adic Deligne–Lusztig varieties
    for GLn. Journal of Algebra. 663(2), 81–118.
  mla: Löwit, Jakub. “On modulo ℓ Cohomology of P-Adic Deligne–Lusztig Varieties for
    GLn.” <i>Journal of Algebra</i>, vol. 663, no. 2, Elsevier, 2025, pp. 81–118,
    doi:<a href="https://doi.org/10.1016/j.jalgebra.2024.08.033">10.1016/j.jalgebra.2024.08.033</a>.
  short: J. Löwit, Journal of Algebra 663 (2025) 81–118.
corr_author: '1'
date_created: 2024-09-29T22:01:37Z
date_published: 2025-02-01T00:00:00Z
date_updated: 2025-02-27T12:32:40Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1016/j.jalgebra.2024.08.033
external_id:
  arxiv:
  - '2404.11176'
  isi:
  - '001325207800001'
file:
- access_level: open_access
  checksum: eb240e93c178e48429ad918c9058f1fe
  content_type: application/pdf
  creator: dernst
  date_created: 2025-01-13T08:57:57Z
  date_updated: 2025-01-13T08:57:57Z
  file_id: '18830'
  file_name: 2024_JourAlgebra_Loewit.pdf
  file_size: 731175
  relation: main_file
  success: 1
file_date_updated: 2025-01-13T08:57:57Z
has_accepted_license: '1'
intvolume: '       663'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 81-118
publication: Journal of Algebra
publication_identifier:
  eissn:
  - 1090-266X
  issn:
  - 0021-8693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On modulo ℓ cohomology of p-adic Deligne–Lusztig varieties for GLn
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 663
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18157'
abstract:
- lang: eng
  text: "Interest in sliding block puzzles dates back to the 15-puzzle, seemingly
    invented by Noyes Chapman in 1874 (see [23] for an account of the fascinating
    history of the puzzle). The game consists of fifteen movable square blocks numbered
    \r\n and arranged within a \r\n square box, leaving one empty space (see Figure
    1). The task at hand is to start from a given configuration of the numbered blocks
    and reach the desired target configuration, where the only allowed move is to
    slide a numbered block into an adjacent empty space. This task seemed to be unpredictably
    either very easy to accomplish, or completely impossible, and the puzzle turned
    into a worldwide sensation in the spring of 1880. A particularly challenging instance,
    known as the 13-15-14 puzzle, consisted of initial and target configurations that
    differed by a single swap (historically this swap involved the blocks labeled
    14 and 15). The craze of this puzzle was such that it consistently made newspaper
    headlines in 1880, with an article in the New York Times lamenting that it was
    “threatening our free institutions” [23, p. 9]. Various prizes were offered for
    anyone who could solve this challenge, beginning with a $25 set of teeth and culminating
    with Sam Loyd’s famous $1,000 cash prize."
acknowledgement: Open access funding provided by Copenhagen University.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Florestan R
  full_name: Brunck, Florestan R
  id: 6ab6e556-f394-11eb-9cf6-9dfb78f00d8d
  last_name: Brunck
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
citation:
  ama: 'Brunck FR, Kwan MA. Books, Hallways, and social butterflies: A note on sliding
    block puzzles. <i>Mathematical Intelligencer</i>. 2025;47:52-65. doi:<a href="https://doi.org/10.1007/s00283-024-10358-x">10.1007/s00283-024-10358-x</a>'
  apa: 'Brunck, F. R., &#38; Kwan, M. A. (2025). Books, Hallways, and social butterflies:
    A note on sliding block puzzles. <i>Mathematical Intelligencer</i>. Springer Nature.
    <a href="https://doi.org/10.1007/s00283-024-10358-x">https://doi.org/10.1007/s00283-024-10358-x</a>'
  chicago: 'Brunck, Florestan R, and Matthew Alan Kwan. “Books, Hallways, and Social
    Butterflies: A Note on Sliding Block Puzzles.” <i>Mathematical Intelligencer</i>.
    Springer Nature, 2025. <a href="https://doi.org/10.1007/s00283-024-10358-x">https://doi.org/10.1007/s00283-024-10358-x</a>.'
  ieee: 'F. R. Brunck and M. A. Kwan, “Books, Hallways, and social butterflies: A
    note on sliding block puzzles,” <i>Mathematical Intelligencer</i>, vol. 47. Springer
    Nature, pp. 52–65, 2025.'
  ista: 'Brunck FR, Kwan MA. 2025. Books, Hallways, and social butterflies: A note
    on sliding block puzzles. Mathematical Intelligencer. 47, 52–65.'
  mla: 'Brunck, Florestan R., and Matthew Alan Kwan. “Books, Hallways, and Social
    Butterflies: A Note on Sliding Block Puzzles.” <i>Mathematical Intelligencer</i>,
    vol. 47, Springer Nature, 2025, pp. 52–65, doi:<a href="https://doi.org/10.1007/s00283-024-10358-x">10.1007/s00283-024-10358-x</a>.'
  short: F.R. Brunck, M.A. Kwan, Mathematical Intelligencer 47 (2025) 52–65.
date_created: 2024-09-29T22:01:38Z
date_published: 2025-03-01T00:00:00Z
date_updated: 2025-05-19T14:00:09Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
- _id: MaKw
doi: 10.1007/s00283-024-10358-x
external_id:
  arxiv:
  - '2303.09459'
  isi:
  - '001318056000001'
file:
- access_level: open_access
  checksum: c932ebe45c460d4a73f5b2dcca643db1
  content_type: application/pdf
  creator: dernst
  date_created: 2025-04-08T11:17:45Z
  date_updated: 2025-04-08T11:17:45Z
  file_id: '19530'
  file_name: 2025_MathIntelligencer_Brunck.pdf
  file_size: 1760643
  relation: main_file
  success: 1
file_date_updated: 2025-04-08T11:17:45Z
has_accepted_license: '1'
intvolume: '        47'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 52-65
publication: Mathematical Intelligencer
publication_identifier:
  issn:
  - 0343-6993
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Books, Hallways, and social butterflies: A note on sliding block puzzles'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18169'
abstract:
- lang: eng
  text: "As the complexity and criticality of software increase every year, so does
    the importance of runtime monitoring. Third-party and best-effort monitoring are
    especially valuable, yet under-explored areas of runtime monitoring. In this context,
    third-party monitoring means monitoring with a limited knowledge of the monitored
    software (as it has been developed by a third party). Best-effort monitoring keeps
    pace with the monitored software at the cost of possibly imprecise verdicts when
    keeping up with the monitored software would not be feasible. Most existing monitoring
    frameworks do not support the combination of third-party and best-effort monitoring
    because they either require the full access to the monitored code or the ability
    to process all observable events, or both.\r\nWe present a middleware framework,
    Vamos, for the runtime monitoring of software. Vamos is explicitly designed to
    support third-party and best-effort scenarios. The design goals of Vamos are (i)
    efficiency (tracing events with low overhead), (ii) flexibility (the ability to
    monitor a variety of different event channels, and to connect to a wide range
    of monitors), and (iii) ease-of-use. To achieve its goals, Vamos combines aspects
    of event broker and event recognition systems with aspects of stream processing
    systems.\r\nWe implemented a prototype toolchain for Vamos and conducted a set
    of experiments demonstrating the usability of the scheme. The results indicate
    that Vamos enables writing useful yet efficient monitors, and simplifies key aspects
    of setting up a monitoring system from scratch."
acknowledgement: This work was supported in part by the ERC-2020-AdG 101020093. The
  authors would like to thank the STTT reviewers for their valuable feedback and suggestions.
article_number: '103212'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Marek
  full_name: Chalupa, Marek
  id: 87e34708-d6c6-11ec-9f5b-9391e7be2463
  last_name: Chalupa
- first_name: Fabian
  full_name: Mühlböck, Fabian
  id: 6395C5F6-89DF-11E9-9C97-6BDFE5697425
  last_name: Mühlböck
  orcid: 0000-0003-1548-0177
- first_name: Stefanie
  full_name: Muroya Lei, Stefanie
  id: a376de31-8972-11ed-ae7b-d0251c13c8ff
  last_name: Muroya Lei
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
citation:
  ama: 'Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. VAMOS: Middleware for best-effort
    third-party monitoring. <i>Science of Computer Programming</i>. 2025;240(2). doi:<a
    href="https://doi.org/10.1016/j.scico.2024.103212">10.1016/j.scico.2024.103212</a>'
  apa: 'Chalupa, M., Mühlböck, F., Muroya Lei, S., &#38; Henzinger, T. A. (2025).
    VAMOS: Middleware for best-effort third-party monitoring. <i>Science of Computer
    Programming</i>. Elsevier. <a href="https://doi.org/10.1016/j.scico.2024.103212">https://doi.org/10.1016/j.scico.2024.103212</a>'
  chicago: 'Chalupa, Marek, Fabian Mühlböck, Stefanie Muroya Lei, and Thomas A Henzinger.
    “VAMOS: Middleware for Best-Effort Third-Party Monitoring.” <i>Science of Computer
    Programming</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.scico.2024.103212">https://doi.org/10.1016/j.scico.2024.103212</a>.'
  ieee: 'M. Chalupa, F. Mühlböck, S. Muroya Lei, and T. A. Henzinger, “VAMOS: Middleware
    for best-effort third-party monitoring,” <i>Science of Computer Programming</i>,
    vol. 240, no. 2. Elsevier, 2025.'
  ista: 'Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. 2025. VAMOS: Middleware
    for best-effort third-party monitoring. Science of Computer Programming. 240(2),
    103212.'
  mla: 'Chalupa, Marek, et al. “VAMOS: Middleware for Best-Effort Third-Party Monitoring.”
    <i>Science of Computer Programming</i>, vol. 240, no. 2, 103212, Elsevier, 2025,
    doi:<a href="https://doi.org/10.1016/j.scico.2024.103212">10.1016/j.scico.2024.103212</a>.'
  short: M. Chalupa, F. Mühlböck, S. Muroya Lei, T.A. Henzinger, Science of Computer
    Programming 240 (2025).
corr_author: '1'
date_created: 2024-10-06T22:01:10Z
date_published: 2025-02-01T00:00:00Z
date_updated: 2025-09-09T12:25:29Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1016/j.scico.2024.103212
ec_funded: 1
external_id:
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month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: Science of Computer Programming
publication_identifier:
  issn:
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publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
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status: public
title: 'VAMOS: Middleware for best-effort third-party monitoring'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 240
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...
---
OA_place: publisher
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abstract:
- lang: eng
  text: 'This study presents a graphene field-effect transistor (gFET) biosensor with
    dual detection capabilities for SARS-CoV-2: one RNA detection assay to confirm
    viral positivity and the other for nucleocapsid (N-)protein detection as a proxy
    for infectiousness of the patient. This technology can be rapidly adapted to emerging
    infectious diseases, making an essential tool to contain future pandemics. To
    detect viral RNA, the highly conserved E-gene of the virus was targeted, allowing
    for the determination of SARS-CoV-2 presence or absence using nasopharyngeal swab
    samples. For N-protein detection, specific antibodies were used. Tested on 213
    clinical nasopharyngeal samples, the gFET biosensor showed good correlation with
    RT-PCR cycle threshold values, proving its high sensitivity in detecting SARS-CoV-2
    RNA. Specificity was confirmed using 21 pre-pandemic samples positive for other
    respiratory viruses. The gFET biosensor had a limit of detection (LOD) for N-protein
    of 0.9 pM, establishing a foundation for the development of a sensitive tool for
    monitoring active viral infection. Results of gFET based N-protein detection corresponded
    to the results of virus culture in all 16 available clinical samples and thus
    it also proved its capability to serve as a proxy for infectivity. Overall, these
    findings support the potential of the gFET biosensor as a point-of-care device
    for rapid diagnosis of SARS-CoV-2 infection and indirect assessment of infectiousness
    in patients, providing additional information for clinical and public health decision-making.'
acknowledgement: 'This research was funded in whole by the Austrian Science Fund (FWF)
  [P 35103-B, Grant-DOI: 10.55776/P35103]. For open access purposes, the author has
  applied a CC BY public copyright license to any author-accepted manuscript version
  arising from this submission. We would like to thank Olfert Landt for advice on
  ssDNA probe design; Rui Qiang Chen, Jennifer Stock, and Christine Wukotitsch for
  their excellent support with ONT sequencing; Christoph Köppl and Andreas Fischer
  for excellent support in recombinant N protein expression and purification; and
  the whole team at the division of clinical virology for their support with standard
  diagnostics.'
article_number: '116807'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Anna Nele
  full_name: Herdina, Anna Nele
  last_name: Herdina
- first_name: Anil
  full_name: Bozdogan, Anil
  last_name: Bozdogan
- first_name: Patrik
  full_name: Aspermair, Patrik
  last_name: Aspermair
- first_name: Jakub
  full_name: Dostalek, Jakub
  last_name: Dostalek
- first_name: Miriam
  full_name: Klausberger, Miriam
  last_name: Klausberger
- first_name: Nico
  full_name: Lingg, Nico
  last_name: Lingg
- first_name: Monika
  full_name: Cserjan-Puschmann, Monika
  last_name: Cserjan-Puschmann
- first_name: Patricia Pereira
  full_name: Aguilar, Patricia Pereira
  last_name: Aguilar
- first_name: Simone
  full_name: Auer, Simone
  last_name: Auer
- first_name: Halil
  full_name: Demirtas, Halil
  last_name: Demirtas
- first_name: Jakob
  full_name: Andersson, Jakob
  id: 3a5f4167-9bd9-11ed-bd12-a1446d38776f
  last_name: Andersson
- first_name: Felix
  full_name: Lötsch, Felix
  last_name: Lötsch
- first_name: Barbara
  full_name: Holzer, Barbara
  last_name: Holzer
- first_name: Adi
  full_name: Steinrigl, Adi
  last_name: Steinrigl
- first_name: Florian
  full_name: Thalhammer, Florian
  last_name: Thalhammer
- first_name: Julia
  full_name: Schellnegger, Julia
  last_name: Schellnegger
- first_name: Monika
  full_name: Breuer, Monika
  last_name: Breuer
- first_name: Wolfgang
  full_name: Knoll, Wolfgang
  last_name: Knoll
- first_name: Robert
  full_name: Strassl, Robert
  last_name: Strassl
citation:
  ama: 'Herdina AN, Bozdogan A, Aspermair P, et al. Bridging basic science and applied
    diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic
    biosensor technology advancements. <i>Biosensors and Bioelectronics</i>. 2025;267.
    doi:<a href="https://doi.org/10.1016/j.bios.2024.116807">10.1016/j.bios.2024.116807</a>'
  apa: 'Herdina, A. N., Bozdogan, A., Aspermair, P., Dostalek, J., Klausberger, M.,
    Lingg, N., … Strassl, R. (2025). Bridging basic science and applied diagnostics:
    Comprehensive viral diagnostics enabled by graphene-based electronic biosensor
    technology advancements. <i>Biosensors and Bioelectronics</i>. Elsevier. <a href="https://doi.org/10.1016/j.bios.2024.116807">https://doi.org/10.1016/j.bios.2024.116807</a>'
  chicago: 'Herdina, Anna Nele, Anil Bozdogan, Patrik Aspermair, Jakub Dostalek, Miriam
    Klausberger, Nico Lingg, Monika Cserjan-Puschmann, et al. “Bridging Basic Science
    and Applied Diagnostics: Comprehensive Viral Diagnostics Enabled by Graphene-Based
    Electronic Biosensor Technology Advancements.” <i>Biosensors and Bioelectronics</i>.
    Elsevier, 2025. <a href="https://doi.org/10.1016/j.bios.2024.116807">https://doi.org/10.1016/j.bios.2024.116807</a>.'
  ieee: 'A. N. Herdina <i>et al.</i>, “Bridging basic science and applied diagnostics:
    Comprehensive viral diagnostics enabled by graphene-based electronic biosensor
    technology advancements,” <i>Biosensors and Bioelectronics</i>, vol. 267. Elsevier,
    2025.'
  ista: 'Herdina AN, Bozdogan A, Aspermair P, Dostalek J, Klausberger M, Lingg N,
    Cserjan-Puschmann M, Aguilar PP, Auer S, Demirtas H, Andersson J, Lötsch F, Holzer
    B, Steinrigl A, Thalhammer F, Schellnegger J, Breuer M, Knoll W, Strassl R. 2025.
    Bridging basic science and applied diagnostics: Comprehensive viral diagnostics
    enabled by graphene-based electronic biosensor technology advancements. Biosensors
    and Bioelectronics. 267, 116807.'
  mla: 'Herdina, Anna Nele, et al. “Bridging Basic Science and Applied Diagnostics:
    Comprehensive Viral Diagnostics Enabled by Graphene-Based Electronic Biosensor
    Technology Advancements.” <i>Biosensors and Bioelectronics</i>, vol. 267, 116807,
    Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.bios.2024.116807">10.1016/j.bios.2024.116807</a>.'
  short: A.N. Herdina, A. Bozdogan, P. Aspermair, J. Dostalek, M. Klausberger, N.
    Lingg, M. Cserjan-Puschmann, P.P. Aguilar, S. Auer, H. Demirtas, J. Andersson,
    F. Lötsch, B. Holzer, A. Steinrigl, F. Thalhammer, J. Schellnegger, M. Breuer,
    W. Knoll, R. Strassl, Biosensors and Bioelectronics 267 (2025).
date_created: 2024-10-06T22:01:11Z
date_published: 2025-01-01T00:00:00Z
date_updated: 2025-02-27T12:34:07Z
day: '01'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1016/j.bios.2024.116807
external_id:
  isi:
  - '001328413700001'
  pmid:
  - '39341071'
file:
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  date_created: 2025-01-13T11:14:32Z
  date_updated: 2025-01-13T11:14:32Z
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  file_size: 4135372
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file_date_updated: 2025-01-13T11:14:32Z
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language:
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month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Biosensors and Bioelectronics
publication_identifier:
  eissn:
  - 1873-4235
  issn:
  - 0956-5663
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bridging basic science and applied diagnostics: Comprehensive viral diagnostics
  enabled by graphene-based electronic biosensor technology advancements'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 267
year: '2025'
...
