---
_id: '14343'
abstract:
- lang: eng
text: The total energy of an eigenstate in a composite quantum system tends to be
distributed equally among its constituents. We identify the quantum fluctuation
around this equipartition principle in the simplest disordered quantum system
consisting of linear combinations of Wigner matrices. As our main ingredient,
we prove the Eigenstate Thermalisation Hypothesis and Gaussian fluctuation for
general quadratic forms of the bulk eigenvectors of Wigner matrices with an arbitrary
deformation.
acknowledgement: "G.C. and L.E. gratefully acknowledge many discussions with Dominik
Schröder at the preliminary stage of this project, especially his essential contribution
to identify the correct generalisation of traceless observables to the deformed
Wigner ensembles.\r\nL.E. and J.H. acknowledges support by ERC Advanced Grant ‘RMTBeyond’
No. 101020331."
article_number: e74
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Oleksii
full_name: Kolupaiev, Oleksii
id: 149b70d4-896a-11ed-bdf8-8c63fd44ca61
last_name: Kolupaiev
orcid: 0000-0003-1491-4623
citation:
ama: Cipolloni G, Erdös L, Henheik SJ, Kolupaiev O. Gaussian fluctuations in the
equipartition principle for Wigner matrices. Forum of Mathematics, Sigma.
2023;11. doi:10.1017/fms.2023.70
apa: Cipolloni, G., Erdös, L., Henheik, S. J., & Kolupaiev, O. (2023). Gaussian
fluctuations in the equipartition principle for Wigner matrices. Forum of Mathematics,
Sigma. Cambridge University Press. https://doi.org/10.1017/fms.2023.70
chicago: Cipolloni, Giorgio, László Erdös, Sven Joscha Henheik, and Oleksii Kolupaiev.
“Gaussian Fluctuations in the Equipartition Principle for Wigner Matrices.” Forum
of Mathematics, Sigma. Cambridge University Press, 2023. https://doi.org/10.1017/fms.2023.70.
ieee: G. Cipolloni, L. Erdös, S. J. Henheik, and O. Kolupaiev, “Gaussian fluctuations
in the equipartition principle for Wigner matrices,” Forum of Mathematics,
Sigma, vol. 11. Cambridge University Press, 2023.
ista: Cipolloni G, Erdös L, Henheik SJ, Kolupaiev O. 2023. Gaussian fluctuations
in the equipartition principle for Wigner matrices. Forum of Mathematics, Sigma.
11, e74.
mla: Cipolloni, Giorgio, et al. “Gaussian Fluctuations in the Equipartition Principle
for Wigner Matrices.” Forum of Mathematics, Sigma, vol. 11, e74, Cambridge
University Press, 2023, doi:10.1017/fms.2023.70.
short: G. Cipolloni, L. Erdös, S.J. Henheik, O. Kolupaiev, Forum of Mathematics,
Sigma 11 (2023).
corr_author: '1'
date_created: 2023-09-17T22:01:09Z
date_published: 2023-08-23T00:00:00Z
date_updated: 2026-04-07T12:37:10Z
day: '23'
ddc:
- '510'
department:
- _id: LaEr
- _id: GradSch
doi: 10.1017/fms.2023.70
ec_funded: 1
external_id:
arxiv:
- '2301.05181'
isi:
- '001051980200001'
file:
- access_level: open_access
checksum: eb747420e6a88a7796fa934151957676
content_type: application/pdf
creator: dernst
date_created: 2023-09-20T11:09:35Z
date_updated: 2023-09-20T11:09:35Z
file_id: '14352'
file_name: 2023_ForumMathematics_Cipolloni.pdf
file_size: 852652
relation: main_file
success: 1
file_date_updated: 2023-09-20T11:09:35Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
eissn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
related_material:
record:
- id: '19540'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Gaussian fluctuations in the equipartition principle for Wigner matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2023'
...
---
_id: '17378'
abstract:
- lang: eng
text: Generative Pre-trained Transformer models, known as GPT or OPT, set themselves
apart through breakthrough performance across complex language modelling tasks,
but also by their extremely high computational and storage costs. Specifically,
due to their massive size, even inference for large, highly-accurate GPT models
may require multiple performant GPUs, which limits the usability of such models.
While there is emerging work on relieving this pressure via model compression,
the applicability and performance of existing compression techniques is limited
by the scale and complexity of GPT models. In this paper, we address this challenge,
and propose OPTQ, a new one-shot weight quantization method based on approximate
second-order information, that is both highly-accurate and highly-efficient. Specifically,
OPTQ can quantize GPT models with 175 billion parameters in approximately four
GPU hours, reducing the bitwidth down to 3 or 4 bits per weight, with negligible
accuracy degradation relative to the uncompressed baseline. Our method more than
doubles the compression gains relative to previously-proposed one-shot quantization
methods, preserving accuracy, allowing us for the first time to execute an 175
billion-parameter model inside a single GPU for generative inference. Moreover,
we also show that our method can still provide reasonable accuracy in the extreme
quantization regime, in which weights are quantized to 2-bit or even ternary quantization
levels. We show experimentally that these improvements can be leveraged for end-to-end
inference speedups over FP16, of around 3.25x when using high-end GPUs (NVIDIA
A100) and 4.5x when using more cost-effective ones (NVIDIA A6000). The implementation
is available at https://github.com/IST-DASLab/gptq.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: Elias Frantar and Dan Alistarh gratefully acknowledge funding from
the European Research Council (ERC) under the European Union’s Horizon 2020 programme
(grant agreement No. 805223 ScaleML), as well as experimental support from Eldar
Kurtic, and from the IST Austria IT department, in particular Stefano Elefante,
Andrei Hornoiu, and Alois Schloegl. The work of Saleh Ashkboos and Torsten Hoefler
was supported by the PASC DaCeMI project, received EuroHPC-JU funding under grant
MAELSTROM, No. 955513. We thank the Swiss National Supercomputing Center (CSCS)
for supporting us with compute infrastructure.
article_processing_charge: No
author:
- first_name: Elias
full_name: Frantar, Elias
id: 09a8f98d-ec99-11ea-ae11-c063a7b7fe5f
last_name: Frantar
- first_name: Saleh
full_name: Ashkboos, Saleh
last_name: Ashkboos
- first_name: Torsten
full_name: Hoefler, Torsten
last_name: Hoefler
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Frantar E, Ashkboos S, Hoefler T, Alistarh D-A. OPTQ: Accurate post-training
quantization for generative pre-trained transformers. In: 11th International
Conference on Learning Representations . International Conference on Learning
Representations; 2023.'
apa: 'Frantar, E., Ashkboos, S., Hoefler, T., & Alistarh, D.-A. (2023). OPTQ:
Accurate post-training quantization for generative pre-trained transformers. In
11th International Conference on Learning Representations . Kigali, Rwanda:
International Conference on Learning Representations.'
chicago: 'Frantar, Elias, Saleh Ashkboos, Torsten Hoefler, and Dan-Adrian Alistarh.
“OPTQ: Accurate Post-Training Quantization for Generative Pre-Trained Transformers.”
In 11th International Conference on Learning Representations . International
Conference on Learning Representations, 2023.'
ieee: 'E. Frantar, S. Ashkboos, T. Hoefler, and D.-A. Alistarh, “OPTQ: Accurate
post-training quantization for generative pre-trained transformers,” in 11th
International Conference on Learning Representations , Kigali, Rwanda, 2023.'
ista: 'Frantar E, Ashkboos S, Hoefler T, Alistarh D-A. 2023. OPTQ: Accurate post-training
quantization for generative pre-trained transformers. 11th International Conference
on Learning Representations . ICLR: International Conference on Learning Representations.'
mla: 'Frantar, Elias, et al. “OPTQ: Accurate Post-Training Quantization for Generative
Pre-Trained Transformers.” 11th International Conference on Learning Representations
, International Conference on Learning Representations, 2023.'
short: E. Frantar, S. Ashkboos, T. Hoefler, D.-A. Alistarh, in:, 11th International
Conference on Learning Representations , International Conference on Learning
Representations, 2023.
conference:
end_date: 2023-05-05
location: Kigali, Rwanda
name: 'ICLR: International Conference on Learning Representations'
start_date: 2023-05-01
corr_author: '1'
date_created: 2024-08-04T22:01:22Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2026-04-07T12:43:03Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
ec_funded: 1
file:
- access_level: open_access
checksum: aacbf11dbd8b02a3e0bfd942a33e0593
content_type: application/pdf
creator: dernst
date_created: 2024-08-05T07:52:44Z
date_updated: 2024-08-05T07:52:44Z
file_id: '17385'
file_name: 2023_ICLR_Frantar.pdf
file_size: 437492
relation: main_file
success: 1
file_date_updated: 2024-08-05T07:52:44Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: '11th International Conference on Learning Representations '
publication_status: published
publisher: International Conference on Learning Representations
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/IST-DASLab/gptq
record:
- id: '17485'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'OPTQ: Accurate post-training quantization for generative pre-trained transformers'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14458'
abstract:
- lang: eng
text: 'We show for the first time that large-scale generative pretrained transformer
(GPT) family models can be pruned to at least 50% sparsity in one-shot, without
any retraining, at minimal loss of accuracy. This is achieved via a new pruning
method called SparseGPT, specifically designed to work efficiently and accurately
on massive GPT-family models. We can execute SparseGPT on the largest available
open-source models, OPT-175B and BLOOM-176B, in under 4.5 hours, and can reach
60% unstructured sparsity with negligible increase in perplexity: remarkably,
more than 100 billion weights from these models can be ignored at inference time.
SparseGPT generalizes to semi-structured (2:4 and 4:8) patterns, and is compatible
with weight quantization approaches. The code is available at: https://github.com/IST-DASLab/sparsegpt.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: The authors gratefully acknowledge funding from the European Research
Council (ERC) under the European Union’s Horizon 2020 programme (grant agreement
No. 805223 ScaleML), as well as experimental support from Eldar Kurtic, and from
the IST Austria IT department, in particular Stefano Elefante, Andrei Hornoiu, and
Alois Schloegl.
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Elias
full_name: Frantar, Elias
id: 09a8f98d-ec99-11ea-ae11-c063a7b7fe5f
last_name: Frantar
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Frantar E, Alistarh D-A. SparseGPT: Massive language models can be accurately
pruned in one-shot. In: Proceedings of the 40th International Conference on
Machine Learning. Vol 202. ML Research Press; 2023:10323-10337.'
apa: 'Frantar, E., & Alistarh, D.-A. (2023). SparseGPT: Massive language models
can be accurately pruned in one-shot. In Proceedings of the 40th International
Conference on Machine Learning (Vol. 202, pp. 10323–10337). Honolulu, Hawaii,
HI, United States: ML Research Press.'
chicago: 'Frantar, Elias, and Dan-Adrian Alistarh. “SparseGPT: Massive Language
Models Can Be Accurately Pruned in One-Shot.” In Proceedings of the 40th International
Conference on Machine Learning, 202:10323–37. ML Research Press, 2023.'
ieee: 'E. Frantar and D.-A. Alistarh, “SparseGPT: Massive language models can be
accurately pruned in one-shot,” in Proceedings of the 40th International Conference
on Machine Learning, Honolulu, Hawaii, HI, United States, 2023, vol. 202,
pp. 10323–10337.'
ista: 'Frantar E, Alistarh D-A. 2023. SparseGPT: Massive language models can be
accurately pruned in one-shot. Proceedings of the 40th International Conference
on Machine Learning. ICML: International Conference on Machine Learning, PMLR,
vol. 202, 10323–10337.'
mla: 'Frantar, Elias, and Dan-Adrian Alistarh. “SparseGPT: Massive Language Models
Can Be Accurately Pruned in One-Shot.” Proceedings of the 40th International
Conference on Machine Learning, vol. 202, ML Research Press, 2023, pp. 10323–37.'
short: E. Frantar, D.-A. Alistarh, in:, Proceedings of the 40th International Conference
on Machine Learning, ML Research Press, 2023, pp. 10323–10337.
conference:
end_date: 2023-07-29
location: Honolulu, Hawaii, HI, United States
name: 'ICML: International Conference on Machine Learning'
start_date: 2023-07-23
corr_author: '1'
date_created: 2023-10-29T23:01:16Z
date_published: 2023-07-30T00:00:00Z
date_updated: 2026-04-07T12:43:03Z
day: '30'
department:
- _id: DaAl
ec_funded: 1
external_id:
arxiv:
- '2301.00774'
intvolume: ' 202'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2301.00774
month: '07'
oa: 1
oa_version: Preprint
page: 10323-10337
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the 40th International Conference on Machine Learning
publication_identifier:
eissn:
- 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '17485'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'SparseGPT: Massive language models can be accurately pruned in one-shot'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2023'
...
---
OA_place: repository
_id: '18294'
abstract:
- lang: eng
text: Using a two-dimensional version of the delta method, we establish an asymptotic
formula for the number of rational points of bounded height on non-singular complete
intersections of cubic and quadric hypersurfaces of dimension at least 23 over
Fq(t), provided cha(Fq)>3. Under the same hypotheses, we also verify weak approximation.
article_number: '2306.02718'
article_processing_charge: No
arxiv: 1
author:
- first_name: Jakob
full_name: Glas, Jakob
id: d6423cba-dc74-11ea-a0a7-ee61689ff5fb
last_name: Glas
citation:
ama: Glas J. Complete intersections of cubic and quadric hypersurfaces over Fq(t).
arXiv. doi:10.48550/arXiv.2306.02718
apa: Glas, J. (n.d.). Complete intersections of cubic and quadric hypersurfaces
over Fq(t). arXiv. https://doi.org/10.48550/arXiv.2306.02718
chicago: Glas, Jakob. “Complete Intersections of Cubic and Quadric Hypersurfaces
over Fq(T).” ArXiv, n.d. https://doi.org/10.48550/arXiv.2306.02718.
ieee: J. Glas, “Complete intersections of cubic and quadric hypersurfaces over Fq(t),”
arXiv. .
ista: Glas J. Complete intersections of cubic and quadric hypersurfaces over Fq(t).
arXiv, 2306.02718.
mla: Glas, Jakob. “Complete Intersections of Cubic and Quadric Hypersurfaces over
Fq(T).” ArXiv, 2306.02718, doi:10.48550/arXiv.2306.02718.
short: J. Glas, ArXiv (n.d.).
corr_author: '1'
date_created: 2024-10-10T13:08:05Z
date_published: 2023-06-05T00:00:00Z
date_updated: 2026-04-07T12:53:53Z
day: '05'
department:
- _id: TiBr
doi: 10.48550/arXiv.2306.02718
external_id:
arxiv:
- '2306.02718'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2306.02718
month: '06'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: draft
related_material:
record:
- id: '18132'
relation: dissertation_contains
status: public
status: public
title: Complete intersections of cubic and quadric hypersurfaces over Fq(t)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: repository
_id: '14732'
abstract:
- lang: eng
text: 'Fragmented landscapes pose a significant threat to the persistence of species
as they are highly susceptible to heightened risk of extinction due to the combined
effects of genetic and demographic factors such as genetic drift and demographic
stochasticity. This paper explores the intricate interplay between genetic load
and extinction risk within metapopulations with a focus on understanding the impact
of eco-evolutionary feedback mechanisms. We distinguish between two models of
selection: soft selection, characterised by subpopulations maintaining carrying
capacity despite load, and hard selection, where load can significantly affect
population size. Within the soft selection framework, we investigate the impact
of gene flow on genetic load at a single locus, while also considering the effect
of selection strength and dominance coefficient. We subsequently build on this
to examine how gene flow influences both population size and load under hard selection
as well as identify critical thresholds for metapopulation persistence. Our analysis
employs the diffusion, semi-deterministic and effective migration approximations.
Our findings reveal that under soft selection, even modest levels of migration
can significantly alleviate the burden of load. In sharp contrast, with hard selection,
a much higher degree of gene flow is required to mitigate load and prevent the
collapse of the metapopulation. Overall, this study sheds light into the crucial
role migration plays in shaping the dynamics of genetic load and extinction risk
in fragmented landscapes, offering valuable insights for conservation strategies
and the preservation of diversity in a changing world.'
article_processing_charge: No
author:
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
and extinction in a metapopulation. bioRxiv. doi:10.1101/2023.12.02.569702
apa: Olusanya, O. O., Khudiakova, K., & Sachdeva, H. (n.d.). Genetic load, eco-evolutionary
feedback and extinction in a metapopulation. bioRxiv. https://doi.org/10.1101/2023.12.02.569702
chicago: Olusanya, Oluwafunmilola O, Kseniia Khudiakova, and Himani Sachdeva. “Genetic
Load, Eco-Evolutionary Feedback and Extinction in a Metapopulation.” BioRxiv,
n.d. https://doi.org/10.1101/2023.12.02.569702.
ieee: O. O. Olusanya, K. Khudiakova, and H. Sachdeva, “Genetic load, eco-evolutionary
feedback and extinction in a metapopulation,” bioRxiv. .
ista: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
and extinction in a metapopulation. bioRxiv, 10.1101/2023.12.02.569702.
mla: Olusanya, Oluwafunmilola O., et al. “Genetic Load, Eco-Evolutionary Feedback
and Extinction in a Metapopulation.” BioRxiv, doi:10.1101/2023.12.02.569702.
short: O.O. Olusanya, K. Khudiakova, H. Sachdeva, BioRxiv (n.d.).
corr_author: '1'
date_created: 2024-01-04T09:35:54Z
date_published: 2023-12-04T00:00:00Z
date_updated: 2026-04-07T12:54:28Z
day: '04'
department:
- _id: NiBa
- _id: JaMa
doi: 10.1101/2023.12.02.569702
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2023.12.02.569702v1
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
- _id: 34d33d68-11ca-11ed-8bc3-ec13763c0ca8
grant_number: '26293'
name: The impact of deleterious mutations on small populations
- _id: 34c872fe-11ca-11ed-8bc3-8534b82131e6
grant_number: '26380'
name: Polygenic Adaptation in a Metapopulation
publication: bioRxiv
publication_status: draft
related_material:
record:
- id: '21322'
relation: later_version
status: public
- id: '14711'
relation: dissertation_contains
status: public
status: public
title: Genetic load, eco-evolutionary feedback and extinction in a metapopulation
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12334'
abstract:
- lang: eng
text: Regulation of the Arp2/3 complex is required for productive nucleation of
branched actin networks. An emerging aspect of regulation is the incorporation
of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit
isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity
and branch junction stability. We have combined reverse genetics and cellular
structural biology to describe how ArpC5 and ArpC5L differentially affect cell
migration. Both define the structural stability of ArpC1 in branch junctions and,
in turn, by determining protrusion characteristics, affect protein dynamics and
actin network ultrastructure. ArpC5 isoforms also affect the positioning of members
of the Ena/Vasodilator-stimulated phosphoprotein (VASP) family of actin filament
elongators, which mediate ArpC5 isoform–specific effects on the actin assembly
level. Our results suggest that ArpC5 and Ena/VASP proteins are part of a signaling
pathway enhancing cell migration.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: "We would like to thank K. von Peinen and B. Denker (Helmholtz Centre
for Infection Research, Braunschweig, Germany) for experimental and technical assistance,
respectively.\r\nThis research was supported by the Scientific Service Units (SSUs)
of ISTA through resources provided by Scientific Computing (SciComp), the Life Science
Facility (LSF), the Imaging and Optics facility (IOF), and the Electron Microscopy
Facility (EMF). We acknowledge support from ISTA and from the Austrian Science Fund
(FWF) (P33367) to F.K.M.S., from the Research Training Group GRK2223 and the Helmholtz
Society to K.R,. and from the Deutsche Forschungsgemeinschaft (DFG) to J.F. and
K.R."
article_number: add6495
article_processing_charge: No
article_type: original
author:
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Manjunath
full_name: Javoor, Manjunath
id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
last_name: Javoor
orcid: 0000-0003-2311-2112
- first_name: Julia
full_name: Datler, Julia
id: 3B12E2E6-F248-11E8-B48F-1D18A9856A87
last_name: Datler
orcid: 0000-0002-3616-8580
- first_name: Hermann
full_name: Döring, Hermann
last_name: Döring
- first_name: Florian
full_name: Hofer, Florian
id: b9d234ba-9e33-11ed-95b6-cd561df280e6
last_name: Hofer
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Victor-Valentin
full_name: Hodirnau, Victor-Valentin
id: 3661B498-F248-11E8-B48F-1D18A9856A87
last_name: Hodirnau
orcid: 0000-0003-3904-947X
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Fäßler F, Javoor M, Datler J, et al. ArpC5 isoforms regulate Arp2/3 complex–dependent
protrusion through differential Ena/VASP positioning. Science Advances.
2023;9(3). doi:10.1126/sciadv.add6495
apa: Fäßler, F., Javoor, M., Datler, J., Döring, H., Hofer, F., Dimchev, G. A.,
… Schur, F. K. (2023). ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion
through differential Ena/VASP positioning. Science Advances. American Association
for the Advancement of Science. https://doi.org/10.1126/sciadv.add6495
chicago: Fäßler, Florian, Manjunath Javoor, Julia Datler, Hermann Döring, Florian
Hofer, Georgi A Dimchev, Victor-Valentin Hodirnau, Jan Faix, Klemens Rottner,
and Florian KM Schur. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion
through Differential Ena/VASP Positioning.” Science Advances. American
Association for the Advancement of Science, 2023. https://doi.org/10.1126/sciadv.add6495.
ieee: F. Fäßler et al., “ArpC5 isoforms regulate Arp2/3 complex–dependent
protrusion through differential Ena/VASP positioning,” Science Advances,
vol. 9, no. 3. American Association for the Advancement of Science, 2023.
ista: Fäßler F, Javoor M, Datler J, Döring H, Hofer F, Dimchev GA, Hodirnau V-V,
Faix J, Rottner K, Schur FK. 2023. ArpC5 isoforms regulate Arp2/3 complex–dependent
protrusion through differential Ena/VASP positioning. Science Advances. 9(3),
add6495.
mla: Fäßler, Florian, et al. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion
through Differential Ena/VASP Positioning.” Science Advances, vol. 9, no.
3, add6495, American Association for the Advancement of Science, 2023, doi:10.1126/sciadv.add6495.
short: F. Fäßler, M. Javoor, J. Datler, H. Döring, F. Hofer, G.A. Dimchev, V.-V.
Hodirnau, J. Faix, K. Rottner, F.K. Schur, Science Advances 9 (2023).
corr_author: '1'
date_created: 2023-01-23T07:26:42Z
date_published: 2023-01-20T00:00:00Z
date_updated: 2026-04-07T12:59:44Z
day: '20'
ddc:
- '570'
department:
- _id: FlSc
- _id: EM-Fac
doi: 10.1126/sciadv.add6495
external_id:
isi:
- '000964550100015'
pmid:
- '36662867'
file:
- access_level: open_access
checksum: ce81a6d0b84170e5e8c62f6acfa15d9e
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T07:45:54Z
date_updated: 2023-01-23T07:45:54Z
file_id: '12335'
file_name: 2023_ScienceAdvances_Faessler.pdf
file_size: 1756234
relation: main_file
success: 1
file_date_updated: 2023-01-23T07:45:54Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '3'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
publication: Science Advances
publication_identifier:
issn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
record:
- id: '14562'
relation: research_data
status: public
- id: '18766'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential
Ena/VASP positioning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2023'
...
---
OA_place: repository
_id: '17351'
abstract:
- lang: eng
text: "Contractive coupling rates have been recently introduced by Conforti as a\r\ntool
to establish convex Sobolev inequalities (including modified log-Sobolev\r\nand
Poincar\\'{e} inequality) for some classes of Markov chains. In this work,\r\nwe
show how contractive coupling rates can also be used to prove stronger\r\ninequalities,
in the form of curvature lower bounds for Markov chains and\r\ngeodesic convexity
of entropic functionals. We illustrate this in several\r\nexamples discussed by
Conforti, where in particular, after appropriately\r\nchoosing a parameter function,
we establish positive curvature in the entropic\r\nand (discrete) Bakry--\\'{E}mery
sense. In addition, we recall and give\r\nstraightforward generalizations of some
notions of coarse Ricci curvature, and\r\nwe discuss some of their properties
and relations with the concepts of\r\ncouplings and coupling rates: as an application,
we show exponential\r\ncontraction of the $p$-Wasserstein distance for the heat
flow in the\r\naforementioned examples."
article_number: '2308.00516'
article_processing_charge: No
arxiv: 1
author:
- first_name: Francesco
full_name: Pedrotti, Francesco
id: d3ac8ac6-dc8d-11ea-abe3-e2a9628c4c3c
last_name: Pedrotti
citation:
ama: Pedrotti F. Contractive coupling rates and curvature lower bounds for Markov
chains. arXiv. doi:10.48550/arXiv.2308.00516
apa: Pedrotti, F. (n.d.). Contractive coupling rates and curvature lower bounds
for Markov chains. arXiv. https://doi.org/10.48550/arXiv.2308.00516
chicago: Pedrotti, Francesco. “Contractive Coupling Rates and Curvature Lower Bounds
for Markov Chains.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2308.00516.
ieee: F. Pedrotti, “Contractive coupling rates and curvature lower bounds for Markov
chains,” arXiv. .
ista: Pedrotti F. Contractive coupling rates and curvature lower bounds for Markov
chains. arXiv, 2308.00516.
mla: Pedrotti, Francesco. “Contractive Coupling Rates and Curvature Lower Bounds
for Markov Chains.” ArXiv, 2308.00516, doi:10.48550/arXiv.2308.00516.
short: F. Pedrotti, ArXiv (n.d.).
corr_author: '1'
date_created: 2024-07-31T08:02:16Z
date_published: 2023-08-02T00:00:00Z
date_updated: 2026-04-07T13:00:02Z
day: '02'
department:
- _id: JaMa
doi: 10.48550/arXiv.2308.00516
external_id:
arxiv:
- '2308.00516'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2308.00516
month: '08'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: draft
related_material:
record:
- id: '20040'
relation: later_version
status: public
- id: '17336'
relation: dissertation_contains
status: public
status: public
title: Contractive coupling rates and curvature lower bounds for Markov chains
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14461'
abstract:
- lang: eng
text: 'Communication-reduction techniques are a popular way to improve scalability
in data-parallel training of deep neural networks (DNNs). The recent emergence
of large language models such as GPT has created the need for new approaches to
exploit data-parallelism. Among these, fully-sharded data parallel (FSDP) training
is highly popular, yet it still encounters scalability bottlenecks. One reason
is that applying compression techniques to FSDP is challenging: as the vast majority
of the communication involves the model’s weights, direct compression alters convergence
and leads to accuracy loss. We present QSDP, a variant of FSDP which supports
both gradient and weight quantization with theoretical guarantees, is simple to
implement and has essentially no overheads. To derive QSDP we prove that a natural
modification of SGD achieves convergence even when we only maintain quantized
weights, and thus the domain over which we train consists of quantized points
and is, therefore, highly non-convex. We validate this approach by training GPT-family
models with up to 1.3 billion parameters on a multi-node cluster. Experiments
show that QSDP preserves model accuracy, while completely removing the communication
bottlenecks of FSDP, providing end-to-end speedups of up to 2.2x.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: The authors gratefully acknowledge funding from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No 805223 ScaleML), as well as experimental support from the IST
Austria IT department, in particular Stefano Elefante, Andrei Hornoiu, and Alois
Schloegl. AV acknowledges the support of the French Agence Nationale de la Recherche
(ANR), under grant ANR-21-CE48-0016 (project COMCOPT), the support of Fondation
Hadamard with a PRMO grant, and the support of CNRS with a CoopIntEER IEA grant
(project ALFRED).
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Ilia
full_name: Markov, Ilia
id: D0CF4148-C985-11E9-8066-0BDEE5697425
last_name: Markov
- first_name: Adrian
full_name: Vladu, Adrian
last_name: Vladu
- first_name: Qi
full_name: Guo, Qi
last_name: Guo
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Markov I, Vladu A, Guo Q, Alistarh D-A. Quantized distributed training of
large models with convergence guarantees. In: Proceedings of the 40th International
Conference on Machine Learning. Vol 202. ML Research Press; 2023:24020-24044.'
apa: 'Markov, I., Vladu, A., Guo, Q., & Alistarh, D.-A. (2023). Quantized distributed
training of large models with convergence guarantees. In Proceedings of the
40th International Conference on Machine Learning (Vol. 202, pp. 24020–24044).
Honolulu, Hawaii, HI, United States: ML Research Press.'
chicago: Markov, Ilia, Adrian Vladu, Qi Guo, and Dan-Adrian Alistarh. “Quantized
Distributed Training of Large Models with Convergence Guarantees.” In Proceedings
of the 40th International Conference on Machine Learning, 202:24020–44. ML
Research Press, 2023.
ieee: I. Markov, A. Vladu, Q. Guo, and D.-A. Alistarh, “Quantized distributed training
of large models with convergence guarantees,” in Proceedings of the 40th International
Conference on Machine Learning, Honolulu, Hawaii, HI, United States, 2023,
vol. 202, pp. 24020–24044.
ista: 'Markov I, Vladu A, Guo Q, Alistarh D-A. 2023. Quantized distributed training
of large models with convergence guarantees. Proceedings of the 40th International
Conference on Machine Learning. ICML: International Conference on Machine Learning,
PMLR, vol. 202, 24020–24044.'
mla: Markov, Ilia, et al. “Quantized Distributed Training of Large Models with Convergence
Guarantees.” Proceedings of the 40th International Conference on Machine Learning,
vol. 202, ML Research Press, 2023, pp. 24020–44.
short: I. Markov, A. Vladu, Q. Guo, D.-A. Alistarh, in:, Proceedings of the 40th
International Conference on Machine Learning, ML Research Press, 2023, pp. 24020–24044.
conference:
end_date: 2023-07-29
location: Honolulu, Hawaii, HI, United States
name: 'ICML: International Conference on Machine Learning'
start_date: 2023-07-23
corr_author: '1'
date_created: 2023-10-29T23:01:17Z
date_published: 2023-07-30T00:00:00Z
date_updated: 2026-04-07T13:00:54Z
day: '30'
department:
- _id: DaAl
ec_funded: 1
external_id:
arxiv:
- '2302.02390'
intvolume: ' 202'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2302.02390
month: '07'
oa: 1
oa_version: Preprint
page: 24020-24044
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the 40th International Conference on Machine Learning
publication_identifier:
eissn:
- 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '17490'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Quantized distributed training of large models with convergence guarantees
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2023'
...
---
OA_place: repository
_id: '17174'
abstract:
- lang: eng
text: We prove that a class of weakly perturbed Hamiltonians of the form $H_λ= H_0
+ λW$, with $W$ being a Wigner matrix, exhibits prethermalization. That is, the
time evolution generated by $H_λ$ relaxes to its ultimate thermal state via an
intermediate prethermal state with a lifetime of order $λ^{-2}$. Moreover, we
obtain a general relaxation formula, expressing the perturbed dynamics via the
unperturbed dynamics and the ultimate thermal state. The proof relies on a two-resolvent
law for the deformed Wigner matrix $H_λ$.
article_number: '2310.06677'
article_processing_charge: No
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Jana
full_name: Reker, Jana
id: e796e4f9-dc8d-11ea-abe3-97e26a0323e9
last_name: Reker
- first_name: Volodymyr
full_name: Riabov, Volodymyr
id: 1949f904-edfb-11eb-afb5-e2dfddabb93b
last_name: Riabov
citation:
ama: Erdös L, Henheik SJ, Reker J, Riabov V. Prethermalization for deformed Wigner
Matrices. arXiv. doi:10.48550/arXiv.2310.06677
apa: Erdös, L., Henheik, S. J., Reker, J., & Riabov, V. (n.d.). Prethermalization
for deformed Wigner Matrices. arXiv. https://doi.org/10.48550/arXiv.2310.06677
chicago: Erdös, László, Sven Joscha Henheik, Jana Reker, and Volodymyr Riabov. “Prethermalization
for Deformed Wigner Matrices.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2310.06677.
ieee: L. Erdös, S. J. Henheik, J. Reker, and V. Riabov, “Prethermalization for deformed
Wigner Matrices,” arXiv. .
ista: Erdös L, Henheik SJ, Reker J, Riabov V. Prethermalization for deformed Wigner
Matrices. arXiv, 2310.06677.
mla: Erdös, László, et al. “Prethermalization for Deformed Wigner Matrices.” ArXiv,
2310.06677, doi:10.48550/arXiv.2310.06677.
short: L. Erdös, S.J. Henheik, J. Reker, V. Riabov, ArXiv (n.d.).
corr_author: '1'
date_created: 2024-06-26T08:56:52Z
date_published: 2023-12-23T00:00:00Z
date_updated: 2026-04-07T13:02:12Z
day: '23'
department:
- _id: LaEr
doi: 10.48550/arXiv.2310.06677
ec_funded: 1
external_id:
arxiv:
- '2310.06677'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2310.06677
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: arXiv
publication_status: draft
related_material:
record:
- id: '18764'
relation: later_version
status: public
- id: '20575'
relation: dissertation_contains
status: public
- id: '17164'
relation: dissertation_contains
status: public
status: public
title: Prethermalization for deformed Wigner Matrices
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
OA_place: repository
_id: '17173'
abstract:
- lang: eng
text: Consider the random variable $\mathrm{Tr}( f_1(W)A_1\dots f_k(W)A_k)$ where
$W$ is an $N\times N$ Hermitian Wigner matrix, $k\in\mathbb{N}$, and choose (possibly
$N$-dependent) regular functions $f_1,\dots, f_k$ as well as bounded deterministic
matrices $A_1,\dots,A_k$. We give a functional central limit theorem showing that
the fluctuations around the expectation are Gaussian. Moreover, we determine the
limiting covariance structure and give explicit error bounds in terms of the scaling
of $f_1,\dots,f_k$ and the number of traceless matrices among $A_1,\dots,A_k$,
thus extending the results of [Cipolloni, Erdős, Schröder 2023] to products of
arbitrary length $k\geq2$. As an application, we consider the fluctuation of $\mathrm{Tr}(\mathrm{e}^{\mathrm{i}
tW}A_1\mathrm{e}^{-\mathrm{i} tW}A_2)$ around its thermal value $\mathrm{Tr}(A_1)\mathrm{Tr}(A_2)$
when $t$ is large and give an explicit formula for the variance.
article_number: '2307.11028'
article_processing_charge: No
arxiv: 1
author:
- first_name: Jana
full_name: Reker, Jana
id: e796e4f9-dc8d-11ea-abe3-97e26a0323e9
last_name: Reker
citation:
ama: Reker J. Multi-point functional central limit theorem for Wigner Matrices.
arXiv. doi:10.48550/arXiv.2307.11028
apa: Reker, J. (n.d.). Multi-point functional central limit theorem for Wigner Matrices.
arXiv. https://doi.org/10.48550/arXiv.2307.11028
chicago: Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.”
ArXiv, n.d. https://doi.org/10.48550/arXiv.2307.11028.
ieee: J. Reker, “Multi-point functional central limit theorem for Wigner Matrices,”
arXiv. .
ista: Reker J. Multi-point functional central limit theorem for Wigner Matrices.
arXiv, 2307.11028.
mla: Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.”
ArXiv, 2307.11028, doi:10.48550/arXiv.2307.11028.
short: J. Reker, ArXiv (n.d.).
date_created: 2024-06-26T08:54:56Z
date_published: 2023-07-21T00:00:00Z
date_updated: 2026-04-07T13:02:12Z
day: '21'
department:
- _id: LaEr
doi: 10.48550/arXiv.2307.11028
external_id:
arxiv:
- '2307.11028'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2307.11028
month: '07'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: draft
related_material:
record:
- id: '18762'
relation: later_version
status: public
- id: '17164'
relation: dissertation_contains
status: public
status: public
title: Multi-point functional central limit theorem for Wigner Matrices
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: publisher
_id: '12716'
abstract:
- lang: eng
text: "The process of detecting and evaluating sensory information to guide behaviour
is termed perceptual decision-making (PDM), and is critical for the ability of
an organism to interact with its external world. Individuals with autism, a neurodevelopmental
condition primarily characterised by social and communication difficulties, frequently
exhibit altered sensory processing and PDM difficulties are widely reported. Recent
technological advancements have pushed forward our understanding of the genetic
changes accompanying this condition, however our understanding of how these mutations
affect the function of specific neuronal circuits and bring about the corresponding
behavioural changes remains limited. Here, we use an innate PDM task, the looming
avoidance response (LAR) paradigm, to identify a convergent behavioural abnormality
across three molecularly distinct genetic mouse models of autism (Cul3, Setd5
and Ptchd1). Although mutant mice can rapidly detect threatening visual stimuli,
their responses are consistently delayed, requiring longer to initiate an appropriate
response than their wild-type siblings. Mutant animals show abnormal adaptation
in both their stimulus- evoked escape responses and exploratory dynamics following
repeated stimulus presentations. Similarly delayed behavioural responses are observed
in wild-type animals when faced with more ambiguous threats, suggesting the mutant
phenotype could arise from a dysfunction in the flexible control of this PDM process.\r\nOur
knowledge of the core neuronal circuitry mediating the LAR facilitated a detailed
dissection of the neuronal mechanisms underlying the behavioural impairment. In
vivo extracellular recording revealed that visual responses were unaffected within
a key brain region for the rapid processing of visual threats, the superior colliculus
(SC), indicating that the behavioural delay was unlikely to originate from sensory
impairments. Delayed behavioural responses were recapitulated in the Setd5 model
following optogenetic stimulation of the excitatory output neurons of the SC,
which are known to mediate escape initiation through the activation of cells in
the underlying dorsal periaqueductal grey (dPAG). In vitro patch-clamp recordings
of dPAG cells uncovered a stark hypoexcitability phenotype in two out of the three
genetic models investigated (Setd5 and Ptchd1), that in Setd5, is mediated by
the misregulation of voltage-gated potassium channels. Overall, our results show
that the ability to use visual information to drive efficient escape responses
is impaired in three diverse genetic mouse models of autism and that, in one of
the models studied, this behavioural delay likely originates from differences
in the intrinsic excitability of a key subcortical node, the dPAG. Furthermore,
this work showcases the use of an innate behavioural paradigm to mechanistically
dissect PDM processes in autism."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: LifeSc
- _id: M-Shop
- _id: CampIT
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Laura
full_name: Burnett, Laura
id: 3B717F68-F248-11E8-B48F-1D18A9856A87
last_name: Burnett
orcid: 0000-0002-8937-410X
citation:
ama: Burnett L. To flee, or not to flee? Using innate defensive behaviours to investigate
rapid perceptual decision-making through subcortical circuits in mouse models
of autism. 2023. doi:10.15479/at:ista:12716
apa: Burnett, L. (2023). To flee, or not to flee? Using innate defensive behaviours
to investigate rapid perceptual decision-making through subcortical circuits in
mouse models of autism. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12716
chicago: Burnett, Laura. “To Flee, or Not to Flee? Using Innate Defensive Behaviours
to Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in
Mouse Models of Autism.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12716.
ieee: L. Burnett, “To flee, or not to flee? Using innate defensive behaviours to
investigate rapid perceptual decision-making through subcortical circuits in mouse
models of autism,” Institute of Science and Technology Austria, 2023.
ista: Burnett L. 2023. To flee, or not to flee? Using innate defensive behaviours
to investigate rapid perceptual decision-making through subcortical circuits in
mouse models of autism. Institute of Science and Technology Austria.
mla: Burnett, Laura. To Flee, or Not to Flee? Using Innate Defensive Behaviours
to Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in
Mouse Models of Autism. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:12716.
short: L. Burnett, To Flee, or Not to Flee? Using Innate Defensive Behaviours to
Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in Mouse
Models of Autism, Institute of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-03-08T15:19:45Z
date_published: 2023-03-10T00:00:00Z
date_updated: 2026-04-07T13:25:15Z
day: '10'
ddc:
- '599'
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaJö
doi: 10.15479/at:ista:12716
ec_funded: 1
file:
- access_level: closed
checksum: 6c6d9cc2c4cdacb74e6b1047a34d7332
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: lburnett
date_created: 2023-03-08T15:08:46Z
date_updated: 2023-03-08T15:08:46Z
file_id: '12717'
file_name: Burnett_Thesis_2023.docx
file_size: 23029260
relation: source_file
- access_level: open_access
checksum: cebc77705288bf4382db9b3541483cd0
content_type: application/pdf
creator: lburnett
date_created: 2023-03-08T15:08:46Z
date_updated: 2023-03-08T15:08:46Z
file_id: '12718'
file_name: Burnett_Thesis_2023_pdfA.pdf
file_size: 11959869
relation: main_file
success: 1
file_date_updated: 2023-03-08T15:08:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '178'
project:
- _id: 2634E9D2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '756502'
name: Circuits of Visual Attention
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: To flee, or not to flee? Using innate defensive behaviours to investigate rapid
perceptual decision-making through subcortical circuits in mouse models of autism
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
OA_place: publisher
_id: '14547'
abstract:
- lang: eng
text: "Superconductor-semiconductor heterostructures currently capture a significant
amount of research interest and they serve as the physical platform in many proposals
towards topological quantum computation.\r\nDespite being under extensive investigations,
historically using transport techniques, the basic properties of the interface
between the superconductor and the semiconductor remain to be understood.\r\n\r\nIn
this thesis, two separate studies on the Al-InAs heterostructures are reported
with the first focusing on the physics of the material motivated by the emergence
of a new phase, the Bogoliubov-Fermi surface. \r\nThe second focuses on a technological
application, a gate-tunable Josephson parametric amplifier.\r\n\r\nIn the first
study, we investigate the hypothesized unconventional nature of the induced superconductivity
at the interface between the Al thin film and the InAs quantum well.\r\nWe embed
a two-dimensional Al-InAs hybrid system in a resonant microwave circuit allowing
measurements of change in inductance.\r\nThe behaviour of the resonance in a range
of temperature and in-plane magnetic field has been studied and compared with
the theory of conventional s-wave superconductor and a two-component theory that
includes both contribution of the $s$-wave pairing in Al and the intraband $p
\\pm ip$ pairing in InAs.\r\nMeasuring the temperature dependence of resonant
frequency, no discrepancy is found between data and the conventional theory.\r\nWe
observe the breakdown of superconductivity due to an applied magnetic field which
contradicts the conventional theory.\r\nIn contrast, the data can be captured
quantitatively by fitting to a two-component model.\r\nWe find the evidence of
the intraband $p \\pm ip$ pairing in the InAs and the emergence of the Bogoliubov-Fermi
surfaces due to magnetic field with the characteristic value $B^* = 0.33~\\mathrm{T}$.\r\nFrom
the fits, the sheet resistance of Al, the carrier density and mobility in InAs
are determined.\r\nBy systematically studying the anisotropy of the circuit response,
we find weak anisotropy for $B < B^*$ and increasingly strong anisotropy for $B
> B^*$ resulting in a pronounced two-lobe structure in polar plot of frequency
versus field angle.\r\nStrong resemblance between the field dependence of dissipation
and superfluid density hints at a hidden signature of the Bogoliubov-Fermi surface
that is burried in the dissipation data.\r\n\r\nIn the second study, we realize
a parametric amplifier with a Josephson field effect transistor as the active
element.\r\nThe device's modest construction consists of a gated SNS weak link
embedded at the center of a coplanar waveguide resonator.\r\nBy applying a gate
voltage, the resonant frequency is field-effect tunable over a range of 2 GHz.\r\nModelling
the JoFET minimally as a parallel RL circuit, the dissipation introduced by the
JoFET can be quantitatively related to the gate voltage.\r\nWe observed gate-tunable
Kerr nonlinearity qualitatively in line with expectation.\r\nThe JoFET amplifier
has 20 dB of gain, 4 MHz of instantaneous bandwidth, and a 1dB compression point
of -125.5 dBm when operated at a fixed resonant frequency.\r\nIn general, the
signal-to-noise ratio is improved by 5-7 dB when the JoFET amplifier is activated
compared.\r\nThe noise of the measurement chain and insertion loss of relevant
circuit elements are calibrated to determine the expected and the real noise performance
of the JoFET amplifier.\r\nAs a quantification of the noise performance, the measured
total input-referred noise of the JoFET amplifier is in good agreement with the
estimated expectation which takes device loss into account.\r\nWe found that the
noise performance of the device reported in this document approaches one photon
of total input-referred added noise which is the quantum limit imposed in nondegenerate
parametric amplifier."
acknowledged_ssus:
- _id: NanoFab
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Duc T
full_name: Phan, Duc T
id: 29C8C0B4-F248-11E8-B48F-1D18A9856A87
last_name: Phan
citation:
ama: Phan DT. Resonant microwave spectroscopy of Al-InAs. 2023. doi:10.15479/14547
apa: Phan, D. T. (2023). Resonant microwave spectroscopy of Al-InAs. Institute
of Science and Technology Austria. https://doi.org/10.15479/14547
chicago: Phan, Duc T. “Resonant Microwave Spectroscopy of Al-InAs.” Institute of
Science and Technology Austria, 2023. https://doi.org/10.15479/14547.
ieee: D. T. Phan, “Resonant microwave spectroscopy of Al-InAs,” Institute of Science
and Technology Austria, 2023.
ista: Phan DT. 2023. Resonant microwave spectroscopy of Al-InAs. Institute of Science
and Technology Austria.
mla: Phan, Duc T. Resonant Microwave Spectroscopy of Al-InAs. Institute of
Science and Technology Austria, 2023, doi:10.15479/14547.
short: D.T. Phan, Resonant Microwave Spectroscopy of Al-InAs, Institute of Science
and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-11-17T13:45:26Z
date_published: 2023-11-16T00:00:00Z
date_updated: 2026-04-07T13:25:52Z
day: '16'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: AnHi
doi: 10.15479/14547
file:
- access_level: open_access
checksum: db0c37d213bc002125bd59690e9db246
content_type: application/pdf
creator: pduc
date_created: 2023-11-17T13:36:44Z
date_updated: 2023-11-22T09:46:06Z
file_id: '14548'
file_name: Phan_Thesis_pdfa.pdf
file_size: 34828019
relation: main_file
- access_level: closed
checksum: 8d3bd6afa279a0078ffd13e06bb6d56d
content_type: application/zip
creator: pduc
date_created: 2023-11-17T13:44:53Z
date_updated: 2023-11-17T13:47:54Z
file_id: '14549'
file_name: dissertation_src.zip
file_size: 279319709
relation: source_file
file_date_updated: 2023-11-22T09:46:06Z
has_accepted_license: '1'
keyword:
- superconductor-semiconductor
- superconductivity
- Al
- InAs
- p-wave
- superconductivity
- JPA
- microwave
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: '80'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13264'
relation: part_of_dissertation
status: public
- id: '10851'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
title: Resonant microwave spectroscopy of Al-InAs
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
OA_place: publisher
_id: '14058'
abstract:
- lang: eng
text: "Females and males across species are subject to divergent selective pressures
arising\r\nfrom di↵erent reproductive interests and ecological niches. This often
translates into a\r\nintricate array of sex-specific natural and sexual selection
on traits that have a shared\r\ngenetic basis between both sexes, causing a genetic
sexual conflict. The resolution of\r\nthis conflict mostly relies on the evolution
of sex-specific expression of the shared genes,\r\nleading to phenotypic sexual
dimorphism. Such sex-specific gene expression is thought\r\nto evolve via modifications
of the genetic networks ultimately linked to sex-determining\r\ntranscription
factors. Although much empirical and theoretical evidence supports this\r\nstandard
picture of the molecular basis of sexual conflict resolution, there still are
a\r\nfew open questions regarding the complex array of selective forces driving
phenotypic\r\ndi↵erentiation between the sexes, as well as the molecular mechanisms
underlying sexspecific adaptation. I address some of these open questions in my
PhD thesis.\r\nFirst, how do patterns of phenotypic sexual dimorphism vary within
populations,\r\nas a response to the temporal and spatial changes in sex-specific
selective forces? To\r\ntackle this question, I analyze the patterns of sex-specific
phenotypic variation along\r\nthree life stages and across populations spanning
the whole geographical range of Rumex\r\nhastatulus, a wind-pollinated angiosperm,
in the first Chapter of the thesis.\r\nSecond, how do gene expression patterns
lead to phenotypic dimorphism, and what\r\nare the molecular mechanisms underlying
the observed transcriptomic variation? I\r\naddress this question by examining
the sex- and tissue-specific expression variation in\r\nnewly-generated datasets
of sex-specific expression in heads and gonads of Drosophila\r\nmelanogaster.
I additionally used two complementary approaches for the study of the\r\ngenetic
basis of sex di↵erences in gene expression in the second and third Chapters of\r\nthe
thesis.\r\nThird, how does intersex correlation, thought to be one of the main
aspects constraining the ability for the two sexes to decouple, interact with
the evolution of sexual\r\ndimorphism? I develop models of sex-specific stabilizing
selection, mutation and drift\r\nto formalize common intuition regarding the patterns
of covariation between intersex\r\ncorrelation and sexual dimorphism in the fourth
Chapter of the thesis.\r\nAlltogether, the work described in this PhD thesis provides
useful insights into the\r\nlinks between genetic, transcriptomic and phenotypic
layers of sex-specific variation,\r\nand contributes to our general understanding
of the dynamics of sexual dimorphism\r\nevolution."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
citation:
ama: 'Puixeu Sala G. The molecular basis of sexual dimorphism: Experimental and
theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. 2023. doi:10.15479/at:ista:14058'
apa: 'Puixeu Sala, G. (2023). The molecular basis of sexual dimorphism: Experimental
and theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14058'
chicago: 'Puixeu Sala, Gemma. “The Molecular Basis of Sexual Dimorphism: Experimental
and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:14058.'
ieee: 'G. Puixeu Sala, “The molecular basis of sexual dimorphism: Experimental and
theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation,” Institute of Science and Technology Austria, 2023.'
ista: 'Puixeu Sala G. 2023. The molecular basis of sexual dimorphism: Experimental
and theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. Institute of Science and Technology Austria.'
mla: 'Puixeu Sala, Gemma. The Molecular Basis of Sexual Dimorphism: Experimental
and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14058.'
short: 'G. Puixeu Sala, The Molecular Basis of Sexual Dimorphism: Experimental and
Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation, Institute of Science and Technology Austria, 2023.'
corr_author: '1'
date_created: 2023-08-15T10:20:40Z
date_published: 2023-08-15T00:00:00Z
date_updated: 2026-04-07T13:25:34Z
day: '15'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/at:ista:14058
ec_funded: 1
file:
- access_level: closed
checksum: 4e44e169f2724ee8c9324cd60bcc2b71
content_type: application/zip
creator: gpuixeus
date_created: 2023-08-16T18:15:17Z
date_updated: 2023-08-17T06:55:24Z
file_id: '14075'
file_name: Thesis_latex_forpdfa.zip
file_size: 10891454
relation: source_file
- access_level: open_access
checksum: e10b04cd8f3fecc0d9ef6e6868b6e1e8
content_type: application/pdf
creator: gpuixeus
date_created: 2023-08-18T10:47:55Z
date_updated: 2023-08-18T10:47:55Z
file_id: '14079'
file_name: PhDThesis_PuixeuG.pdf
file_size: 19856686
relation: main_file
success: 1
file_date_updated: 2023-08-18T10:47:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '230'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
grant_number: '25817'
name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication_identifier:
isbn:
- 978-3-99078-035-0
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9803'
relation: research_data
status: public
- id: '12933'
relation: research_data
status: public
- id: '6831'
relation: part_of_dissertation
status: public
- id: '14077'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: 'The molecular basis of sexual dimorphism: Experimental and theoretical characterization
of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14077'
abstract:
- lang: eng
text: "The regulatory architecture of gene expression is known to differ substantially
between sexes in Drosophila, but most studies performed\r\nso far used whole-body
data and only single crosses, which may have limited their scope to detect patterns
that are robust across tissues\r\nand biological replicates. Here, we use allele-specific
gene expression of parental and reciprocal hybrid crosses between 6 Drosophila\r\nmelanogaster
inbred lines to quantify cis- and trans-regulatory variation in heads and gonads
of both sexes separately across 3 replicate\r\ncrosses. Our results suggest that
female and male heads, as well as ovaries, have a similar regulatory architecture.
On the other hand,\r\ntestes display more and substantially different cis-regulatory
effects, suggesting that sex differences in the regulatory architecture that\r\nhave
been previously observed may largely derive from testis-specific effects. We also
examine the difference in cis-regulatory variation\r\nof genes across different
levels of sex bias in gonads and heads. Consistent with the idea that intersex
correlations constrain expression\r\nand can lead to sexual antagonism, we find
more cis variation in unbiased and moderately biased genes in heads. In ovaries,
reduced cis\r\nvariation is observed for male-biased genes, suggesting that cis
variants acting on these genes in males do not lead to changes in ovary\r\nexpression.
Finally, we examine the dominance patterns of gene expression and find that sex-
and tissue-specific patterns of inheritance\r\nas well as trans-regulatory variation
are highly variable across biological crosses, although these were performed in
highly controlled\r\nexperimental conditions. This highlights the importance of
using various genetic backgrounds to infer generalizable patterns."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank members of the Vicoso Group for comments on the manuscript,
the Scientific Computing Unit at ISTA for technical support, and 2 anonymous reviewers
for useful feedback. GP is the recipient of a DOC Fellowship of the Austrian Academy
of Sciences at the Institute of Science and Technology Austria (DOC 25817) and received
funding from the European Union’s Horizon 2020 research and innovation program under
the Marie Skłodowska-Curie Grant (agreement no. 665385).
article_processing_charge: Yes
article_type: original
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Ariana
full_name: Macon, Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Puixeu Sala G, Macon A, Vicoso B. Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster.
G3: Genes, Genomes, Genetics. 2023;13(8). doi:10.1093/g3journal/jkad121'
apa: 'Puixeu Sala, G., Macon, A., & Vicoso, B. (2023). Sex-specific estimation
of cis and trans regulation of gene expression in heads and gonads of Drosophila
melanogaster. G3: Genes, Genomes, Genetics. Oxford University Press. https://doi.org/10.1093/g3journal/jkad121'
chicago: 'Puixeu Sala, Gemma, Ariana Macon, and Beatriz Vicoso. “Sex-Specific Estimation
of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila
Melanogaster.” G3: Genes, Genomes, Genetics. Oxford University Press, 2023.
https://doi.org/10.1093/g3journal/jkad121.'
ieee: 'G. Puixeu Sala, A. Macon, and B. Vicoso, “Sex-specific estimation of cis
and trans regulation of gene expression in heads and gonads of Drosophila melanogaster,”
G3: Genes, Genomes, Genetics, vol. 13, no. 8. Oxford University Press,
2023.'
ista: 'Puixeu Sala G, Macon A, Vicoso B. 2023. Sex-specific estimation of cis and
trans regulation of gene expression in heads and gonads of Drosophila melanogaster.
G3: Genes, Genomes, Genetics. 13(8).'
mla: 'Puixeu Sala, Gemma, et al. “Sex-Specific Estimation of Cis and Trans Regulation
of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” G3: Genes,
Genomes, Genetics, vol. 13, no. 8, Oxford University Press, 2023, doi:10.1093/g3journal/jkad121.'
short: 'G. Puixeu Sala, A. Macon, B. Vicoso, G3: Genes, Genomes, Genetics 13 (2023).'
corr_author: '1'
date_created: 2023-08-18T06:52:14Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2026-04-07T13:25:34Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
- _id: GradSch
doi: 10.1093/g3journal/jkad121
ec_funded: 1
external_id:
isi:
- '001002997200001'
pmid:
- '37259621'
file:
- access_level: open_access
checksum: c62e29fc7c5efbf8356f4c60cab4a2d1
content_type: application/pdf
creator: dernst
date_created: 2023-11-07T09:00:19Z
date_updated: 2023-11-07T09:00:19Z
file_id: '14498'
file_name: 2023_G3_Puixeu.pdf
file_size: 845642
relation: main_file
success: 1
file_date_updated: 2023-11-07T09:00:19Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '8'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
grant_number: '25817'
name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication: 'G3: Genes, Genomes, Genetics'
publication_identifier:
issn:
- 2160-1836
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
record:
- id: '12933'
relation: research_data
status: public
- id: '14058'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Sex-specific estimation of cis and trans regulation of gene expression in heads
and gonads of Drosophila melanogaster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2023'
...
---
_id: '13264'
abstract:
- lang: eng
text: "We build a parametric amplifier with a Josephson field-effect transistor
(JoFET) as the active element. The resonant frequency of the device is field-effect
tunable over a range of 2 GHz. The JoFET amplifier has 20 dB of gain, 4 MHz of
instantaneous bandwidth, and a 1-dB compression point of -125.5 dBm when operated
at a fixed resonance frequency.\r\n\r\n"
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: We thank Shyam Shankar for helpful feedback on the manuscript. We
gratefully acknowledge the support of the ISTA nanofabrication facility, the Miba
Machine Shop, and the eMachine Shop. The NYU team acknowledges support from Army
Research Office Grant No. W911NF2110303.
article_number: '064032'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Duc T
full_name: Phan, Duc T
id: 29C8C0B4-F248-11E8-B48F-1D18A9856A87
last_name: Phan
- first_name: Paul
full_name: Falthansl-Scheinecker, Paul
id: 85b43b21-15b2-11ec-abd3-e2c252cc2285
last_name: Falthansl-Scheinecker
- first_name: Umang
full_name: Mishra, Umang
id: 4328fa4c-f128-11eb-9611-c107b0fe4d51
last_name: Mishra
- first_name: W. M.
full_name: Strickland, W. M.
last_name: Strickland
- first_name: D.
full_name: Langone, D.
last_name: Langone
- first_name: J.
full_name: Shabani, J.
last_name: Shabani
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
citation:
ama: Phan DT, Falthansl-Scheinecker P, Mishra U, et al. Gate-tunable superconductor-semiconductor
parametric amplifier. Physical Review Applied. 2023;19(6). doi:10.1103/PhysRevApplied.19.064032
apa: Phan, D. T., Falthansl-Scheinecker, P., Mishra, U., Strickland, W. M., Langone,
D., Shabani, J., & Higginbotham, A. P. (2023). Gate-tunable superconductor-semiconductor
parametric amplifier. Physical Review Applied. American Physical Society.
https://doi.org/10.1103/PhysRevApplied.19.064032
chicago: Phan, Duc T, Paul Falthansl-Scheinecker, Umang Mishra, W. M. Strickland,
D. Langone, J. Shabani, and Andrew P Higginbotham. “Gate-Tunable Superconductor-Semiconductor
Parametric Amplifier.” Physical Review Applied. American Physical Society,
2023. https://doi.org/10.1103/PhysRevApplied.19.064032.
ieee: D. T. Phan et al., “Gate-tunable superconductor-semiconductor parametric
amplifier,” Physical Review Applied, vol. 19, no. 6. American Physical
Society, 2023.
ista: Phan DT, Falthansl-Scheinecker P, Mishra U, Strickland WM, Langone D, Shabani
J, Higginbotham AP. 2023. Gate-tunable superconductor-semiconductor parametric
amplifier. Physical Review Applied. 19(6), 064032.
mla: Phan, Duc T., et al. “Gate-Tunable Superconductor-Semiconductor Parametric
Amplifier.” Physical Review Applied, vol. 19, no. 6, 064032, American Physical
Society, 2023, doi:10.1103/PhysRevApplied.19.064032.
short: D.T. Phan, P. Falthansl-Scheinecker, U. Mishra, W.M. Strickland, D. Langone,
J. Shabani, A.P. Higginbotham, Physical Review Applied 19 (2023).
corr_author: '1'
date_created: 2023-07-23T22:01:12Z
date_published: 2023-06-09T00:00:00Z
date_updated: 2026-04-07T13:25:51Z
day: '09'
department:
- _id: AnHi
- _id: OnHo
doi: 10.1103/PhysRevApplied.19.064032
external_id:
arxiv:
- '2206.05746'
isi:
- '001012022600004'
intvolume: ' 19'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2206.05746
month: '06'
oa: 1
oa_version: Preprint
publication: Physical Review Applied
publication_identifier:
eissn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '14547'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Gate-tunable superconductor-semiconductor parametric amplifier
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2023'
...
---
_id: '12933'
abstract:
- lang: eng
text: Datasets of the publication "Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster".
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
citation:
ama: 'Puixeu Sala G. Data from: Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster. 2023. doi:10.15479/AT:ISTA:12933'
apa: 'Puixeu Sala, G. (2023). Data from: Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:12933'
chicago: 'Puixeu Sala, Gemma. “Data from: Sex-Specific Estimation of Cis and Trans
Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12933.'
ieee: 'G. Puixeu Sala, “Data from: Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster.” Institute
of Science and Technology Austria, 2023.'
ista: 'Puixeu Sala G. 2023. Data from: Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:12933.'
mla: 'Puixeu Sala, Gemma. Data from: Sex-Specific Estimation of Cis and Trans
Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.
Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:12933.'
short: G. Puixeu Sala, (2023).
contributor:
- first_name: Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
corr_author: '1'
date_created: 2023-05-10T10:00:49Z
date_published: 2023-05-15T00:00:00Z
date_updated: 2026-04-07T13:25:33Z
day: '15'
ddc:
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/AT:ISTA:12933
file:
- access_level: open_access
checksum: 0ba0bcd0bb8b18d84792136a4370df90
content_type: text/csv
creator: gpuixeus
date_created: 2023-05-10T09:41:43Z
date_updated: 2023-05-10T09:41:43Z
file_id: '12934'
file_name: Dataset_S1.csv
file_size: 8029982
relation: main_file
success: 1
- access_level: open_access
checksum: a62aa9a6d4904e0fdb699cf752640863
content_type: text/csv
creator: gpuixeus
date_created: 2023-05-10T09:41:43Z
date_updated: 2023-05-10T09:41:43Z
file_id: '12935'
file_name: Dataset_S2.csv
file_size: 13667640
relation: main_file
success: 1
- access_level: open_access
checksum: e20ea7f4f8a9bdf1b3849a44664ae58b
content_type: text/csv
creator: gpuixeus
date_created: 2023-05-10T09:41:48Z
date_updated: 2023-05-10T09:41:48Z
file_id: '12936'
file_name: Dataset_S3.csv
file_size: 8369141
relation: main_file
success: 1
- access_level: open_access
checksum: f6156e5fc44446c907ddd0d7289d4cf8
content_type: text/csv
creator: gpuixeus
date_created: 2023-05-10T09:41:50Z
date_updated: 2023-05-10T09:41:50Z
file_id: '12937'
file_name: Dataset_S4.csv
file_size: 19543247
relation: main_file
success: 1
- access_level: open_access
checksum: ae9f54c77a1c42b666ae6c1dfd33ac86
content_type: text/plain
creator: gpuixeus
date_created: 2023-05-11T12:50:18Z
date_updated: 2023-05-11T12:50:18Z
file_id: '12944'
file_name: readme.txt
file_size: 4566
relation: main_file
success: 1
file_date_updated: 2023-05-11T12:50:18Z
has_accepted_license: '1'
month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14077'
relation: used_in_publication
status: public
- id: '14058'
relation: used_in_publication
status: public
status: public
title: 'Data from: Sex-specific estimation of cis and trans regulation of gene expression
in heads and gonads of Drosophila melanogaster'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: publisher
_id: '12885'
abstract:
- lang: eng
text: 'High-performance semiconductors rely upon precise control of heat and charge
transport. This can be achieved by precisely engineering defects in polycrystalline
solids. There are multiple approaches to preparing such polycrystalline semiconductors,
and the transformation of solution-processed colloidal nanoparticles is appealing
because colloidal nanoparticles combine low cost with structural and compositional
tunability along with rich surface chemistry. However, the multiple processes
from nanoparticle synthesis to the final bulk nanocomposites are very complex.
They involve nanoparticle purification, post-synthetic modifications, and finally
consolidation (thermal treatments and densification). All these properties dictate
the final material’s composition and microstructure, ultimately affecting its
functional properties. This thesis explores the synthesis, surface chemistry and
consolidation of colloidal semiconductor nanoparticles into dense solids. In particular,
the transformations that take place during these processes, and their effect on
the material’s transport properties are evaluated. '
acknowledged_ssus:
- _id: EM-Fac
- _id: NanoFab
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mariano
full_name: Calcabrini, Mariano
id: 45D7531A-F248-11E8-B48F-1D18A9856A87
last_name: Calcabrini
orcid: 0000-0003-4566-5877
citation:
ama: 'Calcabrini M. Nanoparticle-based semiconductor solids: From synthesis to consolidation.
2023. doi:10.15479/at:ista:12885'
apa: 'Calcabrini, M. (2023). Nanoparticle-based semiconductor solids: From synthesis
to consolidation. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12885'
chicago: 'Calcabrini, Mariano. “Nanoparticle-Based Semiconductor Solids: From Synthesis
to Consolidation.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12885.'
ieee: 'M. Calcabrini, “Nanoparticle-based semiconductor solids: From synthesis to
consolidation,” Institute of Science and Technology Austria, 2023.'
ista: 'Calcabrini M. 2023. Nanoparticle-based semiconductor solids: From synthesis
to consolidation. Institute of Science and Technology Austria.'
mla: 'Calcabrini, Mariano. Nanoparticle-Based Semiconductor Solids: From Synthesis
to Consolidation. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12885.'
short: 'M. Calcabrini, Nanoparticle-Based Semiconductor Solids: From Synthesis to
Consolidation, Institute of Science and Technology Austria, 2023.'
corr_author: '1'
date_created: 2023-05-02T07:58:57Z
date_published: 2023-04-28T00:00:00Z
date_updated: 2026-04-07T13:26:14Z
day: '28'
ddc:
- '546'
- '541'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaIb
doi: 10.15479/at:ista:12885
ec_funded: 1
file:
- access_level: closed
checksum: 9347b0e09425f56fdcede5d3528404dc
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: mcalcabr
date_created: 2023-05-02T07:43:18Z
date_updated: 2023-05-02T07:43:18Z
file_id: '12887'
file_name: Thesis_Calcabrini.docx
file_size: 99627036
relation: source_file
- access_level: open_access
checksum: 2d188b76621086cd384f0b9264b0a576
content_type: application/pdf
creator: mcalcabr
date_created: 2023-05-02T07:42:45Z
date_updated: 2023-05-02T07:42:45Z
file_id: '12888'
file_name: Thesis_Calcabrini_pdfa.pdf
file_size: 8742220
relation: main_file
success: 1
file_date_updated: 2023-05-02T07:43:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '82'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-028-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12237'
relation: part_of_dissertation
status: public
- id: '10806'
relation: part_of_dissertation
status: public
- id: '10123'
relation: part_of_dissertation
status: public
- id: '10042'
relation: part_of_dissertation
status: public
- id: '9118'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
title: 'Nanoparticle-based semiconductor solids: From synthesis to consolidation'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
OA_place: publisher
_id: '12732'
abstract:
- lang: eng
text: "Nonergodic systems, whose out-of-equilibrium dynamics fail to thermalize,
provide a fascinating research direction both for fundamental reasons and for
application in state of the art quantum devices.\r\nGoing beyond the description
of statistical mechanics, ergodicity breaking yields a new paradigm in quantum
many-body physics, introducing novel phases of matter with no counterpart at equilibrium.\r\nIn
this Thesis, we address different open questions in the field, focusing on disorder-induced
many-body localization (MBL) and on weak ergodicity breaking in kinetically constrained
models.\r\nIn particular, we contribute to the debate about transport in kinetically
constrained models, studying the effect of $U(1)$ conservation and inversion-symmetry
breaking in a family of quantum East models.\r\nUsing tensor network techniques,
we analyze the dynamics of large MBL systems beyond the limit of exact numerical
methods.\r\nIn this setting, we approach the debated topic of the coexistence
of localized and thermal eigenstates separated by energy thresholds known as many-body
mobility edges.\r\nInspired by recent experiments, our work further investigates
the localization of a small bath induced by the coupling to a large localized
chain, the so-called MBL proximity effect.\r\n\r\nIn the first Chapter, we introduce
a family of particle-conserving kinetically constrained models, inspired by the
quantum East model.\r\nThe system we study features strong inversion-symmetry
breaking, due to the nature of the correlated hopping.\r\nWe show that these models
host so-called quantum Hilbert space fragmentation, consisting of disconnected
subsectors in an entangled basis, and further provide an analytical description
of this phenomenon.\r\nWe further probe its effect on dynamics of simple product
states, showing revivals in fidelity and local observalbes.\r\nThe study of dynamics
within the largest subsector reveals an anomalous transient superdiffusive behavior
crossing over to slow logarithmic dynamics at later times.\r\nThis work suggests
that particle conserving constrained models with inversion-symmetry breaking realize
new universality classes of dynamics and invite their further theoretical and
experimental studies.\r\n\r\nNext, we use kinetic constraints and disorder to
design a model with many-body mobility edges in particle density.\r\nThis feature
allows to study the dynamics of localized and thermal states in large systems
beyond the limitations of previous studies.\r\nThe time-evolution shows typical
signatures of localization at small densities, replaced by thermal behavior at
larger densities.\r\nOur results provide evidence in favor of the stability of
many-body mobility edges, which was recently challenged by a theoretical argument.\r\nTo
support our findings, we probe the mechanism proposed as a cause of delocalization
in many-body localized systems with mobility edges suggesting its ineffectiveness
in the model studied.\r\n\r\nIn the last Chapter of this Thesis, we address the
topic of many-body localization proximity effect.\r\nWe study a model inspired
by recent experiments, featuring Anderson localized coupled to a small bath of
free hard-core bosons.\r\nThe interaction among the two particle species results
in non-trivial dynamics, which we probe using tensor network techniques.\r\nOur
simulations show convincing evidence of many-body localization proximity effect
when the bath is composed by a single free particle and interactions are strong.\r\nWe
furthter observe an anomalous entanglement dynamics, which we explain through
a phenomenological theory.\r\nFinally, we extract highly excited eigenstates of
large systems, providing supplementary evidence in favor of our findings."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
citation:
ama: Brighi P. Ergodicity breaking in disordered and kinetically constrained quantum
many-body systems. 2023. doi:10.15479/at:ista:12732
apa: Brighi, P. (2023). Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12732
chicago: Brighi, Pietro. “Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:12732.
ieee: P. Brighi, “Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems,” Institute of Science and Technology Austria, 2023.
ista: Brighi P. 2023. Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems. Institute of Science and Technology Austria.
mla: Brighi, Pietro. Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:12732.
short: P. Brighi, Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems, Institute of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-03-17T13:30:48Z
date_published: 2023-03-21T00:00:00Z
date_updated: 2026-04-07T13:26:32Z
day: '21'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaSe
doi: 10.15479/at:ista:12732
ec_funded: 1
file:
- access_level: closed
checksum: 5d2de651ef9449c1b8dc27148ca74777
content_type: application/zip
creator: pbrighi
date_created: 2023-03-23T16:42:56Z
date_updated: 2023-03-23T16:42:56Z
file_id: '12753'
file_name: Thesis_sub_PBrighi.zip
file_size: 42167561
relation: source_file
- access_level: open_access
checksum: 7caa153d4a5b0873a79358787d2dfe1e
content_type: application/pdf
creator: pbrighi
date_created: 2023-03-23T16:43:14Z
date_updated: 2023-03-23T16:43:14Z
file_id: '12754'
file_name: Thesis_PBrighi.pdf
file_size: 13977000
relation: main_file
success: 1
file_date_updated: 2023-03-23T16:43:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '158'
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12750'
relation: part_of_dissertation
status: public
- id: '11470'
relation: part_of_dissertation
status: public
- id: '8308'
relation: part_of_dissertation
status: public
- id: '11469'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
title: Ergodicity breaking in disordered and kinetically constrained quantum many-body
systems
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
OA_place: publisher
_id: '12826'
abstract:
- lang: eng
text: "During navigation, animals can infer the structure of the environment by
computing the optic flow cues elicited by their own movements, and subsequently
use this information to instruct proper locomotor actions. These computations
require a panoramic assessment of the visual environment in order to disambiguate
similar sensory experiences that may require distinct behavioral responses. The
estimation of the global motion patterns is therefore essential for successful
navigation. Yet, our understanding of the algorithms and implementations that
enable coherent panoramic visual perception remains scarce. Here I pursue this
problem by dissecting the functional aspects of interneuronal communication in
the lobula plate tangential cell network in Drosophila melanogaster. The results
presented in the thesis demonstrate that the basis for effective interpretation
of the optic flow in this circuit are stereotyped synaptic connections that mediate
the formation of distinct subnetworks, each extracting a particular pattern of
global motion. \r\nFirstly, I show that gap junctions are essential for a correct
interpretation of binocular motion cues by horizontal motion-sensitive cells.
HS cells form electrical synapses with contralateral H2 neurons that are involved
in detecting yaw rotation and translation. I developed an FlpStop-mediated mutant
of a gap junction protein ShakB that disrupts these electrical synapses. While
the loss of electrical synapses does not affect the tuning of the direction selectivity
in HS neurons, it severely alters their sensitivity to horizontal motion in the
contralateral side. These physiological changes result in an inappropriate integration
of binocular motion cues in walking animals. While wild-type flies form a binocular
perception of visual motion by non-linear integration of monocular optic flow
cues, the mutant flies sum the monocular inputs linearly. These results indicate
that rather than averaging signals in neighboring neurons, gap-junctions operate
in conjunction with chemical synapses to mediate complex non-linear optic flow
computations.\r\nSecondly, I show that stochastic manipulation of neuronal activity
in the lobula plate tangential cell network is a powerful approach to study the
neuronal implementation of optic flow-based navigation in flies. Tangential neurons
form multiple subnetworks, each mediating course-stabilizing response to a particular
global pattern of visual motion. Application of genetic mosaic techniques can
provide sparse optogenetic activation of HS cells in numerous combinations. These
distinct combinations of activated neurons drive an array of distinct behavioral
responses, providing important insights into how visuomotor transformation is
performed in the lobula plate tangential cell network. This approach can be complemented
by stochastic silencing of tangential neurons, enabling direct assessment of the
functional role of individual tangential neurons in the processing of specific
visual motion patterns.\r\n\tTaken together, the findings presented in this thesis
suggest that establishing specific activity patterns of tangential cells via stereotyped
synaptic connectivity is a key to efficient optic flow-based navigation in Drosophila
melanogaster."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Victoria
full_name: Pokusaeva, Victoria
id: 3184041C-F248-11E8-B48F-1D18A9856A87
last_name: Pokusaeva
orcid: 0000-0001-7660-444X
citation:
ama: Pokusaeva V. Neural control of optic flow-based navigation in Drosophila melanogaster.
2023. doi:10.15479/at:ista:12826
apa: Pokusaeva, V. (2023). Neural control of optic flow-based navigation in Drosophila
melanogaster. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12826
chicago: Pokusaeva, Victoria. “Neural Control of Optic Flow-Based Navigation in
Drosophila Melanogaster.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12826.
ieee: V. Pokusaeva, “Neural control of optic flow-based navigation in Drosophila
melanogaster,” Institute of Science and Technology Austria, 2023.
ista: Pokusaeva V. 2023. Neural control of optic flow-based navigation in Drosophila
melanogaster. Institute of Science and Technology Austria.
mla: Pokusaeva, Victoria. Neural Control of Optic Flow-Based Navigation in Drosophila
Melanogaster. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12826.
short: V. Pokusaeva, Neural Control of Optic Flow-Based Navigation in Drosophila
Melanogaster, Institute of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-04-14T14:56:04Z
date_published: 2023-04-18T00:00:00Z
date_updated: 2026-04-07T13:26:49Z
day: '18'
ddc:
- '570'
- '571'
degree_awarded: PhD
department:
- _id: MaJö
- _id: GradSch
doi: 10.15479/at:ista:12826
ec_funded: 1
file:
- access_level: closed
checksum: 5f589a9af025f7eeebfd0c186209913e
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: vpokusae
date_created: 2023-04-20T09:14:38Z
date_updated: 2023-04-20T09:26:51Z
file_id: '12857'
file_name: Thesis_Pokusaeva.docx
file_size: 14507243
relation: source_file
- access_level: open_access
checksum: bbeed76db45a996b4c91a9abe12ce0ec
content_type: application/pdf
creator: vpokusae
date_created: 2023-04-20T09:14:44Z
date_updated: 2023-04-20T09:14:44Z
file_id: '12858'
file_name: Thesis_Pokusaeva.pdf
file_size: 10090711
relation: main_file
success: 1
file_date_updated: 2023-04-20T09:26:51Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '106'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: Neural control of optic flow-based navigation in Drosophila melanogaster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
OA_place: publisher
_id: '13286'
abstract:
- lang: eng
text: Semiconductor-superconductor hybrid systems are the harbour of many intriguing
mesoscopic phenomena. This material combination leads to spatial variations of
the superconducting properties, which gives rise to Andreev bound states (ABSs).
Some of these states might exhibit remarkable properties that render them highly
desirable for topological quantum computing. The most prominent and hunted of
such states are Majorana zero modes (MZMs), quasiparticles equals to their own
quasiparticles that they follow non-abelian statistics. In this thesis, we first
introduce the general framework of such hybrid systems and, then, we unveil a
series of mesoscopic phenomena that we discovered. Firstly, we show tunneling
spectroscopy experiments on full-shell nanowires (NWs) showing that unwanted quantum-dot
states coupled to superconductors (Yu-Shiba-Rusinov states) can mimic MZMs signatures.
Then, we introduce a novel protocol which allowed the integration of tunneling
spectroscopy with Coulomb spectroscopy within the same device. Employing this
approach on both full-shell NWs and partial-shell NWs, we demonstrated that longitudinally
confined states reveal charge transport phenomenology similar to the one expected
for MZMs. These findings shed light on the intricate interplay between superconductivity
and quantum confinement, which brought us to explore another material platform,
i.e. a two-dimensional Germanium hole gas. After developing a robust way to induce
superconductivity in such system, we showed how to engineer the proximity effect
and we revealed a superconducting hard gap. Finally, we created a superconducting
radio frequency driven ideal diode and a generator of non-sinusoidal current-phase
relations. Our results open the path for the exploration of protected superconducting
qubits and more complex hybrid devices in planar Germanium, like Kitaev chains
and hybrid qubit devices.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Marco
full_name: Valentini, Marco
id: C0BB2FAC-D767-11E9-B658-BC13E6697425
last_name: Valentini
citation:
ama: 'Valentini M. Mesoscopic phenomena in hybrid semiconductor-superconductor nanodevices :
From full-shell nanowires to two-dimensional hole gas in germanium. 2023. doi:10.15479/at:ista:13286'
apa: 'Valentini, M. (2023). Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13286'
chicago: 'Valentini, Marco. “Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13286.'
ieee: 'M. Valentini, “Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium,”
Institute of Science and Technology Austria, 2023.'
ista: 'Valentini M. 2023. Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium.
Institute of Science and Technology Austria.'
mla: 'Valentini, Marco. Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13286.'
short: 'M. Valentini, Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium,
Institute of Science and Technology Austria, 2023.'
corr_author: '1'
date_created: 2023-07-24T14:10:45Z
date_published: 2023-07-21T00:00:00Z
date_updated: 2026-04-07T13:27:22Z
day: '21'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: GeKa
doi: 10.15479/at:ista:13286
ec_funded: 1
file:
- access_level: closed
checksum: 666ee31c7eade89679806287c062fa14
content_type: application/x-zip-compressed
creator: mvalenti
date_created: 2023-08-11T09:27:39Z
date_updated: 2023-08-11T10:01:34Z
file_id: '14033'
file_name: PhD_thesis_Valentini_final.zip
file_size: 56121429
relation: source_file
- access_level: open_access
checksum: 0992f2ebef152dee8e70055350ebbb55
content_type: application/pdf
creator: mvalenti
date_created: 2023-08-11T14:39:17Z
date_updated: 2023-08-11T14:39:17Z
file_id: '14035'
file_name: PhD_thesis_Valentini_final_validated.pdf
file_size: 38199711
relation: main_file
file_date_updated: 2023-08-11T14:39:17Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '184'
project:
- _id: 262116AA-B435-11E9-9278-68D0E5697425
name: Hybrid Semiconductor - Superconductor Quantum Devices
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
- _id: 34a66131-11ca-11ed-8bc3-a31681c6b03e
grant_number: F8606
name: 'Center for Correlated Quantum Materials and Solid State Quantum Systems:
Conventional and unconventional topological superconductors'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12522'
relation: research_data
status: public
- id: '13312'
relation: part_of_dissertation
status: public
- id: '12118'
relation: part_of_dissertation
status: public
- id: '8910'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
title: 'Mesoscopic phenomena in hybrid semiconductor-superconductor nanodevices :
From full-shell nanowires to two-dimensional hole gas in germanium'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...