---
_id: '9221'
abstract:
- lang: eng
  text: "Recent works have shown that gradient descent can find a global minimum for
    over-parameterized neural networks where the widths of all the hidden layers scale
    polynomially with N (N being the number of training samples). In this paper, we
    prove that, for deep networks, a single layer of width N following the input layer
    suffices to ensure a similar guarantee. In particular, all the remaining layers
    are allowed to have constant widths, and form a pyramidal topology. We show an
    application of our result to the widely used LeCun’s initialization and obtain
    an over-parameterization requirement for the single wide layer of order N2.\r\n"
acknowledgement: The authors would like to thank Jan Maas, Mahdi Soltanolkotabi, and
  Daniel Soudry for the helpful discussions, Marius Kloft, Matthias Hein and Quoc
  Dinh Tran for proofreading portions of a prior version of this paper, and James
  Martens for a clarification concerning LeCun’s initialization. M. Mondelli was partially
  supported by the 2019 Lopez-Loreta Prize. Q. Nguyen was partially supported by the
  German Research Foundation (DFG) award KL 2698/2-1.
alternative_title:
- Advances in Neural Information Processing Systems
article_processing_charge: No
arxiv: 1
author:
- first_name: Quynh
  full_name: Nguyen, Quynh
  last_name: Nguyen
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
citation:
  ama: 'Nguyen Q, Mondelli M. Global convergence of deep networks with one wide layer
    followed by pyramidal topology. In: <i>34th Conference on Neural Information Processing
    Systems</i>. Vol 33. Neural Information Processing Systems Foundation; 2020:11961–11972.'
  apa: 'Nguyen, Q., &#38; Mondelli, M. (2020). Global convergence of deep networks
    with one wide layer followed by pyramidal topology. In <i>34th Conference on Neural
    Information Processing Systems</i> (Vol. 33, pp. 11961–11972). Vancouver, Canada:
    Neural Information Processing Systems Foundation.'
  chicago: Nguyen, Quynh, and Marco Mondelli. “Global Convergence of Deep Networks
    with One Wide Layer Followed by Pyramidal Topology.” In <i>34th Conference on
    Neural Information Processing Systems</i>, 33:11961–11972. Neural Information
    Processing Systems Foundation, 2020.
  ieee: Q. Nguyen and M. Mondelli, “Global convergence of deep networks with one wide
    layer followed by pyramidal topology,” in <i>34th Conference on Neural Information
    Processing Systems</i>, Vancouver, Canada, 2020, vol. 33, pp. 11961–11972.
  ista: 'Nguyen Q, Mondelli M. 2020. Global convergence of deep networks with one
    wide layer followed by pyramidal topology. 34th Conference on Neural Information
    Processing Systems. NeurIPS: Neural Information Processing Systems, Advances in
    Neural Information Processing Systems, vol. 33, 11961–11972.'
  mla: Nguyen, Quynh, and Marco Mondelli. “Global Convergence of Deep Networks with
    One Wide Layer Followed by Pyramidal Topology.” <i>34th Conference on Neural Information
    Processing Systems</i>, vol. 33, Neural Information Processing Systems Foundation,
    2020, pp. 11961–11972.
  short: Q. Nguyen, M. Mondelli, in:, 34th Conference on Neural Information Processing
    Systems, Neural Information Processing Systems Foundation, 2020, pp. 11961–11972.
conference:
  end_date: 2020-12-12
  location: Vancouver, Canada
  name: 'NeurIPS: Neural Information Processing Systems'
  start_date: 2020-12-06
date_created: 2021-03-03T12:06:02Z
date_published: 2020-07-07T00:00:00Z
date_updated: 2025-05-14T11:27:13Z
day: '07'
department:
- _id: MaMo
external_id:
  arxiv:
  - '2002.07867'
intvolume: '        33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2002.07867
month: '07'
oa: 1
oa_version: Preprint
page: 11961–11972
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: 34th Conference on Neural Information Processing Systems
publication_status: published
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
status: public
title: Global convergence of deep networks with one wide layer followed by pyramidal
  topology
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '9222'
article_processing_charge: No
author:
- first_name: Georgios
  full_name: Katsaros, Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
citation:
  ama: 'Katsaros G. Transport data for: Site‐controlled uniform Ge/Si Hut wires with
    electrically tunable spin–orbit coupling. 2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:9222">10.15479/AT:ISTA:9222</a>'
  apa: 'Katsaros, G. (2020). Transport data for: Site‐controlled uniform Ge/Si Hut
    wires with electrically tunable spin–orbit coupling. Institute of Science and
    Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:9222">https://doi.org/10.15479/AT:ISTA:9222</a>'
  chicago: 'Katsaros, Georgios. “Transport Data for: Site‐controlled Uniform Ge/Si
    Hut Wires with Electrically Tunable Spin–Orbit Coupling.” Institute of Science
    and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:9222">https://doi.org/10.15479/AT:ISTA:9222</a>.'
  ieee: 'G. Katsaros, “Transport data for: Site‐controlled uniform Ge/Si Hut wires
    with electrically tunable spin–orbit coupling.” Institute of Science and Technology
    Austria, 2020.'
  ista: 'Katsaros G. 2020. Transport data for: Site‐controlled uniform Ge/Si Hut wires
    with electrically tunable spin–orbit coupling, Institute of Science and Technology
    Austria, <a href="https://doi.org/10.15479/AT:ISTA:9222">10.15479/AT:ISTA:9222</a>.'
  mla: 'Katsaros, Georgios. <i>Transport Data for: Site‐controlled Uniform Ge/Si Hut
    Wires with Electrically Tunable Spin–Orbit Coupling</i>. Institute of Science
    and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:9222">10.15479/AT:ISTA:9222</a>.'
  short: G. Katsaros, (2020).
contributor:
- contributor_type: research_group
  first_name: Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
corr_author: '1'
date_created: 2021-03-05T18:00:47Z
date_published: 2020-03-16T00:00:00Z
date_updated: 2025-06-12T07:16:21Z
day: '16'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:9222
file:
- access_level: open_access
  checksum: 41b66e195ed3dbd73077feee77b05652
  content_type: application/x-zip-compressed
  creator: gkatsaro
  date_created: 2021-03-05T17:50:45Z
  date_updated: 2021-03-05T17:50:45Z
  file_id: '9223'
  file_name: DOI_SiteControlledHWs.zip
  file_size: 13317557
  relation: main_file
- access_level: open_access
  checksum: a1dc5f710ba4b3bb7f248195ba754ab2
  content_type: text/plain
  creator: dernst
  date_created: 2021-03-10T07:31:50Z
  date_updated: 2021-03-10T07:31:50Z
  file_id: '9233'
  file_name: Readme.txt
  file_size: 3515
  relation: main_file
  success: 1
file_date_updated: 2021-03-10T07:31:50Z
fulldoi: https://doi.org/10.15479/AT:ISTA:9222
has_accepted_license: '1'
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '7541'
    relation: used_in_publication
    status: public
status: public
title: 'Transport data for: Site‐controlled uniform Ge/Si Hut wires with electrically
  tunable spin–orbit coupling'
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '9249'
abstract:
- lang: eng
  text: Rhombic dodecahedron is a space filling polyhedron which represents the close
    packing of spheres in 3D space and the Voronoi structures of the face centered
    cubic (FCC) lattice. In this paper, we describe a new coordinate system where
    every 3-integer coordinates grid point corresponds to a rhombic dodecahedron centroid.
    In order to illustrate the interest of the new coordinate system, we propose the
    characterization of 3D digital plane with its topological features, such as the
    interrelation between the thickness of the digital plane and the separability
    constraint we aim to obtain. We also present the characterization of 3D digital
    lines and study it as the intersection of multiple digital planes. Characterization
    of 3D digital sphere with relevant topological features is proposed as well along
    with the 48-symmetry appearing in the new coordinate system.
acknowledgement: "This work has been partially supported by the European Research
  Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation
  programme, grant no. 788183, and the DFG Collaborative Research Center TRR 109,
  ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no.
  I 02979-N35. "
article_processing_charge: No
article_type: original
author:
- first_name: Ranita
  full_name: Biswas, Ranita
  id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
  last_name: Biswas
  orcid: 0000-0002-5372-7890
- first_name: Gaëlle
  full_name: Largeteau-Skapin, Gaëlle
  last_name: Largeteau-Skapin
- first_name: Rita
  full_name: Zrour, Rita
  last_name: Zrour
- first_name: Eric
  full_name: Andres, Eric
  last_name: Andres
citation:
  ama: Biswas R, Largeteau-Skapin G, Zrour R, Andres E. Digital objects in rhombic
    dodecahedron grid. <i>Mathematical Morphology - Theory and Applications</i>. 2020;4(1):143-158.
    doi:<a href="https://doi.org/10.1515/mathm-2020-0106">10.1515/mathm-2020-0106</a>
  apa: Biswas, R., Largeteau-Skapin, G., Zrour, R., &#38; Andres, E. (2020). Digital
    objects in rhombic dodecahedron grid. <i>Mathematical Morphology - Theory and
    Applications</i>. De Gruyter. <a href="https://doi.org/10.1515/mathm-2020-0106">https://doi.org/10.1515/mathm-2020-0106</a>
  chicago: Biswas, Ranita, Gaëlle Largeteau-Skapin, Rita Zrour, and Eric Andres. “Digital
    Objects in Rhombic Dodecahedron Grid.” <i>Mathematical Morphology - Theory and
    Applications</i>. De Gruyter, 2020. <a href="https://doi.org/10.1515/mathm-2020-0106">https://doi.org/10.1515/mathm-2020-0106</a>.
  ieee: R. Biswas, G. Largeteau-Skapin, R. Zrour, and E. Andres, “Digital objects
    in rhombic dodecahedron grid,” <i>Mathematical Morphology - Theory and Applications</i>,
    vol. 4, no. 1. De Gruyter, pp. 143–158, 2020.
  ista: Biswas R, Largeteau-Skapin G, Zrour R, Andres E. 2020. Digital objects in
    rhombic dodecahedron grid. Mathematical Morphology - Theory and Applications.
    4(1), 143–158.
  mla: Biswas, Ranita, et al. “Digital Objects in Rhombic Dodecahedron Grid.” <i>Mathematical
    Morphology - Theory and Applications</i>, vol. 4, no. 1, De Gruyter, 2020, pp.
    143–58, doi:<a href="https://doi.org/10.1515/mathm-2020-0106">10.1515/mathm-2020-0106</a>.
  short: R. Biswas, G. Largeteau-Skapin, R. Zrour, E. Andres, Mathematical Morphology
    - Theory and Applications 4 (2020) 143–158.
corr_author: '1'
date_created: 2021-03-16T08:55:19Z
date_published: 2020-11-17T00:00:00Z
date_updated: 2025-04-14T07:48:35Z
day: '17'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1515/mathm-2020-0106
ec_funded: 1
file:
- access_level: open_access
  checksum: 4a1043fa0548a725d464017fe2483ce0
  content_type: application/pdf
  creator: dernst
  date_created: 2021-03-22T08:56:37Z
  date_updated: 2021-03-22T08:56:37Z
  file_id: '9272'
  file_name: 2020_MathMorpholTheoryAppl_Biswas.pdf
  file_size: 3668725
  relation: main_file
  success: 1
file_date_updated: 2021-03-22T08:56:37Z
fulldoi: https://doi.org/10.1515/mathm-2020-0106
has_accepted_license: '1'
intvolume: '         4'
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 143-158
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '788183'
  name: Alpha Shape Theory Extended
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I02979-N35
  name: Persistence and stability of geometric complexes
publication: Mathematical Morphology - Theory and Applications
publication_identifier:
  issn:
  - 2353-3390
publication_status: published
publisher: De Gruyter
quality_controlled: '1'
status: public
title: Digital objects in rhombic dodecahedron grid
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
_id: '9299'
abstract:
- lang: eng
  text: We call a multigraph non-homotopic if it can be drawn in the plane in such
    a way that no two edges connecting the same pair of vertices can be continuously
    transformed into each other without passing through a vertex, and no loop can
    be shrunk to its end-vertex in the same way. It is easy to see that a non-homotopic
    multigraph on   n>1  vertices can have arbitrarily many edges. We prove that the
    number of crossings between the edges of a non-homotopic multigraph with n vertices
    and   m>4n  edges is larger than   cm2n  for some constant   c>0 , and that this
    bound is tight up to a polylogarithmic factor. We also show that the lower bound
    is not asymptotically sharp as n is fixed and   m⟶∞ .
acknowledgement: Supported by the National Research, Development and Innovation Office,
  NKFIH, KKP-133864, K-131529, K-116769, K-132696, by the Higher Educational Institutional
  Excellence Program 2019 NKFIH-1158-6/2019, the Austrian Science Fund (FWF), grant
  Z 342-N31, by the Ministry of Education and Science of the Russian Federation MegaGrant
  No. 075-15-2019-1926, and by the ERC Synergy Grant “Dynasnet” No. 810115. A full
  version can be found at https://arxiv.org/abs/2006.14908.
article_processing_charge: No
arxiv: 1
author:
- first_name: János
  full_name: Pach, János
  id: E62E3130-B088-11EA-B919-BF823C25FEA4
  last_name: Pach
- first_name: Gábor
  full_name: Tardos, Gábor
  last_name: Tardos
- first_name: Géza
  full_name: Tóth, Géza
  last_name: Tóth
citation:
  ama: 'Pach J, Tardos G, Tóth G. Crossings between non-homotopic edges. In: <i>28th
    International Symposium on Graph Drawing and Network Visualization</i>. Vol 12590.
    LNCS. Springer Nature; 2020:359-371. doi:<a href="https://doi.org/10.1007/978-3-030-68766-3_28">10.1007/978-3-030-68766-3_28</a>'
  apa: 'Pach, J., Tardos, G., &#38; Tóth, G. (2020). Crossings between non-homotopic
    edges. In <i>28th International Symposium on Graph Drawing and Network Visualization</i>
    (Vol. 12590, pp. 359–371). Virtual, Online: Springer Nature. <a href="https://doi.org/10.1007/978-3-030-68766-3_28">https://doi.org/10.1007/978-3-030-68766-3_28</a>'
  chicago: Pach, János, Gábor Tardos, and Géza Tóth. “Crossings between Non-Homotopic
    Edges.” In <i>28th International Symposium on Graph Drawing and Network Visualization</i>,
    12590:359–71. LNCS. Springer Nature, 2020. <a href="https://doi.org/10.1007/978-3-030-68766-3_28">https://doi.org/10.1007/978-3-030-68766-3_28</a>.
  ieee: J. Pach, G. Tardos, and G. Tóth, “Crossings between non-homotopic edges,”
    in <i>28th International Symposium on Graph Drawing and Network Visualization</i>,
    Virtual, Online, 2020, vol. 12590, pp. 359–371.
  ista: 'Pach J, Tardos G, Tóth G. 2020. Crossings between non-homotopic edges. 28th
    International Symposium on Graph Drawing and Network Visualization. GD: Graph
    Drawing and Network VisualizationLNCS vol. 12590, 359–371.'
  mla: Pach, János, et al. “Crossings between Non-Homotopic Edges.” <i>28th International
    Symposium on Graph Drawing and Network Visualization</i>, vol. 12590, Springer
    Nature, 2020, pp. 359–71, doi:<a href="https://doi.org/10.1007/978-3-030-68766-3_28">10.1007/978-3-030-68766-3_28</a>.
  short: J. Pach, G. Tardos, G. Tóth, in:, 28th International Symposium on Graph Drawing
    and Network Visualization, Springer Nature, 2020, pp. 359–371.
conference:
  end_date: 2020-09-18
  location: Virtual, Online
  name: 'GD: Graph Drawing and Network Visualization'
  start_date: 2020-09-16
date_created: 2021-03-28T22:01:44Z
date_published: 2020-09-20T00:00:00Z
date_updated: 2025-04-15T07:16:52Z
day: '20'
department:
- _id: HeEd
doi: 10.1007/978-3-030-68766-3_28
external_id:
  arxiv:
  - '2006.14908'
fulldoi: https://doi.org/10.1007/978-3-030-68766-3_28
intvolume: '     12590'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2006.14908
month: '09'
oa: 1
oa_version: Preprint
page: 359-371
project:
- _id: 268116B8-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00342
  name: Mathematics, Computer Science
publication: 28th International Symposium on Graph Drawing and Network Visualization
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783030687656'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: Crossings between non-homotopic edges
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12590
year: '2020'
...
---
_id: '9308'
acknowledgement: This research was carried out with the support of the Russian Foundation
  for Basic Research(grant no. 19-01-00169)
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sergey
  full_name: Avvakumov, Sergey
  id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
  last_name: Avvakumov
  orcid: 0000-0002-7840-5062
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
- first_name: Isaac
  full_name: Mabillard, Isaac
  id: 32BF9DAA-F248-11E8-B48F-1D18A9856A87
  last_name: Mabillard
- first_name: A. B.
  full_name: Skopenkov, A. B.
  last_name: Skopenkov
citation:
  ama: Avvakumov S, Wagner U, Mabillard I, Skopenkov AB. Eliminating higher-multiplicity
    intersections, III. Codimension 2. <i>Russian Mathematical Surveys</i>. 2020;75(6):1156-1158.
    doi:<a href="https://doi.org/10.1070/RM9943">10.1070/RM9943</a>
  apa: Avvakumov, S., Wagner, U., Mabillard, I., &#38; Skopenkov, A. B. (2020). Eliminating
    higher-multiplicity intersections, III. Codimension 2. <i>Russian Mathematical
    Surveys</i>. IOP Publishing. <a href="https://doi.org/10.1070/RM9943">https://doi.org/10.1070/RM9943</a>
  chicago: Avvakumov, Sergey, Uli Wagner, Isaac Mabillard, and A. B. Skopenkov. “Eliminating
    Higher-Multiplicity Intersections, III. Codimension 2.” <i>Russian Mathematical
    Surveys</i>. IOP Publishing, 2020. <a href="https://doi.org/10.1070/RM9943">https://doi.org/10.1070/RM9943</a>.
  ieee: S. Avvakumov, U. Wagner, I. Mabillard, and A. B. Skopenkov, “Eliminating higher-multiplicity
    intersections, III. Codimension 2,” <i>Russian Mathematical Surveys</i>, vol.
    75, no. 6. IOP Publishing, pp. 1156–1158, 2020.
  ista: Avvakumov S, Wagner U, Mabillard I, Skopenkov AB. 2020. Eliminating higher-multiplicity
    intersections, III. Codimension 2. Russian Mathematical Surveys. 75(6), 1156–1158.
  mla: Avvakumov, Sergey, et al. “Eliminating Higher-Multiplicity Intersections, III.
    Codimension 2.” <i>Russian Mathematical Surveys</i>, vol. 75, no. 6, IOP Publishing,
    2020, pp. 1156–58, doi:<a href="https://doi.org/10.1070/RM9943">10.1070/RM9943</a>.
  short: S. Avvakumov, U. Wagner, I. Mabillard, A.B. Skopenkov, Russian Mathematical
    Surveys 75 (2020) 1156–1158.
date_created: 2021-04-04T22:01:22Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2025-07-02T10:54:51Z
day: '01'
department:
- _id: UlWa
doi: 10.1070/RM9943
external_id:
  arxiv:
  - '1511.03501'
  isi:
  - '000625983100001'
fulldoi: https://doi.org/10.1070/RM9943
intvolume: '        75'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1511.03501
month: '12'
oa: 1
oa_version: Preprint
page: 1156-1158
publication: Russian Mathematical Surveys
publication_identifier:
  issn:
  - 0036-0279
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
  record:
  - id: '10220'
    relation: later_version
    status: public
  - id: '8183'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Eliminating higher-multiplicity intersections, III. Codimension 2
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 75
year: '2020'
...
---
_id: '9326'
abstract:
- lang: eng
  text: The mitochondrial respiratory chain, formed by five protein complexes, utilizes
    energy from catabolic processes to synthesize ATP. Complex I, the first and the
    largest protein complex of the chain, harvests electrons from NADH to reduce quinone,
    while pumping protons across the mitochondrial membrane. Detailed knowledge of
    the working principle of such coupled charge-transfer processes remains, however,
    fragmentary due to bottlenecks in understanding redox-driven conformational transitions
    and their interplay with the hydrated proton pathways. Complex I from Thermus
    thermophilus encases 16 subunits with nine iron–sulfur clusters, reduced by electrons
    from NADH. Here, employing the latest crystal structure of T. thermophilus complex
    I, we have used microsecond-scale molecular dynamics simulations to study the
    chemo-mechanical coupling between redox changes of the iron–sulfur clusters and
    conformational transitions across complex I. First, we identify the redox switches
    within complex I, which allosterically couple the dynamics of the quinone binding
    pocket to the site of NADH reduction. Second, our free-energy calculations reveal
    that the affinity of the quinone, specifically menaquinone, for the binding-site
    is higher than that of its reduced, menaquinol forma design essential for menaquinol
    release. Remarkably, the barriers to diffusive menaquinone dynamics are lesser
    than that of the more ubiquitous ubiquinone, and the naphthoquinone headgroup
    of the former furnishes stronger binding interactions with the pocket, favoring
    menaquinone for charge transport in T. thermophilus. Our computations are consistent
    with experimentally validated mutations and hierarchize the key residues into
    three functional classes, identifying new mutation targets. Third, long-range
    hydrogen-bond networks connecting the quinone-binding site to the transmembrane
    subunits are found to be responsible for proton pumping. Put together, the simulations
    reveal the molecular design principles linking redox reactions to quinone turnover
    to proton translocation in complex I.
article_processing_charge: No
author:
- first_name: Chitrak
  full_name: Gupta, Chitrak
  last_name: Gupta
- first_name: Umesh
  full_name: Khaniya, Umesh
  last_name: Khaniya
- first_name: Chun
  full_name: Chan, Chun
  last_name: Chan
- first_name: Francois
  full_name: Dehez, Francois
  last_name: Dehez
- first_name: Mrinal
  full_name: Shekhar, Mrinal
  last_name: Shekhar
- first_name: M. R.
  full_name: Gunner, M. R.
  last_name: Gunner
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Christophe
  full_name: Chipot, Christophe
  last_name: Chipot
- first_name: Abhishek
  full_name: Singharoy, Abhishek
  last_name: Singharoy
citation:
  ama: Gupta C, Khaniya U, Chan C, et al. Charge transfer and chemo-mechanical coupling
    in respiratory complex I. 2020. doi:<a href="https://doi.org/10.1021/jacs.9b13450.s002">10.1021/jacs.9b13450.s002</a>
  apa: Gupta, C., Khaniya, U., Chan, C., Dehez, F., Shekhar, M., Gunner, M. R., …
    Singharoy, A. (2020). Charge transfer and chemo-mechanical coupling in respiratory
    complex I. American Chemical Society. <a href="https://doi.org/10.1021/jacs.9b13450.s002">https://doi.org/10.1021/jacs.9b13450.s002</a>
  chicago: Gupta, Chitrak, Umesh Khaniya, Chun Chan, Francois Dehez, Mrinal Shekhar,
    M. R. Gunner, Leonid A Sazanov, Christophe Chipot, and Abhishek Singharoy. “Charge
    Transfer and Chemo-Mechanical Coupling in Respiratory Complex I.” American Chemical
    Society, 2020. <a href="https://doi.org/10.1021/jacs.9b13450.s002">https://doi.org/10.1021/jacs.9b13450.s002</a>.
  ieee: C. Gupta <i>et al.</i>, “Charge transfer and chemo-mechanical coupling in
    respiratory complex I.” American Chemical Society, 2020.
  ista: Gupta C, Khaniya U, Chan C, Dehez F, Shekhar M, Gunner MR, Sazanov LA, Chipot
    C, Singharoy A. 2020. Charge transfer and chemo-mechanical coupling in respiratory
    complex I, American Chemical Society, <a href="https://doi.org/10.1021/jacs.9b13450.s002">10.1021/jacs.9b13450.s002</a>.
  mla: Gupta, Chitrak, et al. <i>Charge Transfer and Chemo-Mechanical Coupling in
    Respiratory Complex I</i>. American Chemical Society, 2020, doi:<a href="https://doi.org/10.1021/jacs.9b13450.s002">10.1021/jacs.9b13450.s002</a>.
  short: C. Gupta, U. Khaniya, C. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov,
    C. Chipot, A. Singharoy, (2020).
date_created: 2021-04-14T12:05:20Z
date_published: 2020-05-20T00:00:00Z
date_updated: 2025-07-10T11:55:01Z
day: '20'
department:
- _id: LeSa
doi: 10.1021/jacs.9b13450.s002
fulldoi: https://doi.org/10.1021/jacs.9b13450.s002
month: '05'
oa_version: Published Version
publisher: American Chemical Society
related_material:
  record:
  - id: '8040'
    relation: used_in_publication
    status: public
status: public
title: Charge transfer and chemo-mechanical coupling in respiratory complex I
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '9526'
abstract:
- lang: eng
  text: DNA methylation and histone H1 mediate transcriptional silencing of genes
    and transposable elements, but how they interact is unclear. In plants and animals
    with mosaic genomic methylation, functionally mysterious methylation is also common
    within constitutively active housekeeping genes. Here, we show that H1 is enriched
    in methylated sequences, including genes, of Arabidopsis thaliana, yet this enrichment
    is independent of DNA methylation. Loss of H1 disperses heterochromatin, globally
    alters nucleosome organization, and activates H1-bound genes, but only weakly
    de-represses transposable elements. However, H1 loss strongly activates transposable
    elements hypomethylated through mutation of DNA methyltransferase MET1. Hypomethylation
    of genes also activates antisense transcription, which is modestly enhanced by
    H1 loss. Our results demonstrate that H1 and DNA methylation jointly maintain
    transcriptional homeostasis by silencing transposable elements and aberrant intragenic
    transcripts. Such functionality plausibly explains why DNA methylation, a well-known
    mutagen, has been maintained within coding sequences of crucial plant and animal
    genes.
article_processing_charge: No
article_type: original
author:
- first_name: Jaemyung
  full_name: Choi, Jaemyung
  last_name: Choi
- first_name: David B.
  full_name: Lyons, David B.
  last_name: Lyons
- first_name: M. Yvonne
  full_name: Kim, M. Yvonne
  last_name: Kim
- first_name: Jonathan D.
  full_name: Moore, Jonathan D.
  last_name: Moore
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Choi J, Lyons DB, Kim MY, Moore JD, Zilberman D. DNA methylation and histone
    H1 jointly repress transposable elements and aberrant intragenic transcripts.
    <i>Molecular Cell</i>. 2020;77(2):310-323.e7. doi:<a href="https://doi.org/10.1016/j.molcel.2019.10.011">10.1016/j.molcel.2019.10.011</a>
  apa: Choi, J., Lyons, D. B., Kim, M. Y., Moore, J. D., &#38; Zilberman, D. (2020).
    DNA methylation and histone H1 jointly repress transposable elements and aberrant
    intragenic transcripts. <i>Molecular Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.molcel.2019.10.011">https://doi.org/10.1016/j.molcel.2019.10.011</a>
  chicago: Choi, Jaemyung, David B. Lyons, M. Yvonne Kim, Jonathan D. Moore, and Daniel
    Zilberman. “DNA Methylation and Histone H1 Jointly Repress Transposable Elements
    and Aberrant Intragenic Transcripts.” <i>Molecular Cell</i>. Elsevier, 2020. <a
    href="https://doi.org/10.1016/j.molcel.2019.10.011">https://doi.org/10.1016/j.molcel.2019.10.011</a>.
  ieee: J. Choi, D. B. Lyons, M. Y. Kim, J. D. Moore, and D. Zilberman, “DNA methylation
    and histone H1 jointly repress transposable elements and aberrant intragenic transcripts,”
    <i>Molecular Cell</i>, vol. 77, no. 2. Elsevier, p. 310–323.e7, 2020.
  ista: Choi J, Lyons DB, Kim MY, Moore JD, Zilberman D. 2020. DNA methylation and
    histone H1 jointly repress transposable elements and aberrant intragenic transcripts.
    Molecular Cell. 77(2), 310–323.e7.
  mla: Choi, Jaemyung, et al. “DNA Methylation and Histone H1 Jointly Repress Transposable
    Elements and Aberrant Intragenic Transcripts.” <i>Molecular Cell</i>, vol. 77,
    no. 2, Elsevier, 2020, p. 310–323.e7, doi:<a href="https://doi.org/10.1016/j.molcel.2019.10.011">10.1016/j.molcel.2019.10.011</a>.
  short: J. Choi, D.B. Lyons, M.Y. Kim, J.D. Moore, D. Zilberman, Molecular Cell 77
    (2020) 310–323.e7.
date_created: 2021-06-08T06:37:09Z
date_published: 2020-01-16T00:00:00Z
date_updated: 2024-10-16T12:14:37Z
day: '16'
department:
- _id: DaZi
doi: 10.1016/j.molcel.2019.10.011
extern: '1'
external_id:
  pmid:
  - '31732458'
fulldoi: https://doi.org/10.1016/j.molcel.2019.10.011
intvolume: '        77'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.molcel.2019.10.011
month: '01'
oa: 1
oa_version: Published Version
page: 310-323.e7
pmid: 1
publication: Molecular Cell
publication_identifier:
  eissn:
  - 1097-4164
  issn:
  - 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: DNA methylation and histone H1 jointly repress transposable elements and aberrant
  intragenic transcripts
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 77
year: '2020'
...
---
_id: '9630'
abstract:
- lang: eng
  text: Various kinds of data are routinely represented as discrete probability distributions.
    Examples include text documents summarized by histograms of word occurrences and
    images represented as histograms of oriented gradients. Viewing a discrete probability
    distribution as a point in the standard simplex of the appropriate dimension,
    we can understand collections of such objects in geometric and topological terms.  Importantly,
    instead of using the standard Euclidean distance, we look into dissimilarity measures
    with information-theoretic justification, and we develop the theory needed for
    applying topological data analysis in this setting. In doing so, we emphasize
    constructions that enable the usage of existing computational topology software
    in this context.
acknowledgement: This research is partially supported by the Office of Naval Research,
  through grant no. N62909-18-1-2038, and the DFG Collaborative Research Center TRR
  109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of
  the Austrian Science Fund (FWF).
article_processing_charge: Yes
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Ziga
  full_name: Virk, Ziga
  id: 2E36B656-F248-11E8-B48F-1D18A9856A87
  last_name: Virk
- first_name: Hubert
  full_name: Wagner, Hubert
  id: 379CA8B8-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0009-0009-9111-8429
citation:
  ama: Edelsbrunner H, Virk Z, Wagner H. Topological data analysis in information
    space. <i>Journal of Computational Geometry</i>. 2020;11(2):162-182. doi:<a href="https://doi.org/10.20382/jocg.v11i2a7">10.20382/jocg.v11i2a7</a>
  apa: Edelsbrunner, H., Virk, Z., &#38; Wagner, H. (2020). Topological data analysis
    in information space. <i>Journal of Computational Geometry</i>. Carleton University.
    <a href="https://doi.org/10.20382/jocg.v11i2a7">https://doi.org/10.20382/jocg.v11i2a7</a>
  chicago: Edelsbrunner, Herbert, Ziga Virk, and Hubert Wagner. “Topological Data
    Analysis in Information Space.” <i>Journal of Computational Geometry</i>. Carleton
    University, 2020. <a href="https://doi.org/10.20382/jocg.v11i2a7">https://doi.org/10.20382/jocg.v11i2a7</a>.
  ieee: H. Edelsbrunner, Z. Virk, and H. Wagner, “Topological data analysis in information
    space,” <i>Journal of Computational Geometry</i>, vol. 11, no. 2. Carleton University,
    pp. 162–182, 2020.
  ista: Edelsbrunner H, Virk Z, Wagner H. 2020. Topological data analysis in information
    space. Journal of Computational Geometry. 11(2), 162–182.
  mla: Edelsbrunner, Herbert, et al. “Topological Data Analysis in Information Space.”
    <i>Journal of Computational Geometry</i>, vol. 11, no. 2, Carleton University,
    2020, pp. 162–82, doi:<a href="https://doi.org/10.20382/jocg.v11i2a7">10.20382/jocg.v11i2a7</a>.
  short: H. Edelsbrunner, Z. Virk, H. Wagner, Journal of Computational Geometry 11
    (2020) 162–182.
corr_author: '1'
date_created: 2021-07-04T22:01:26Z
date_published: 2020-12-14T00:00:00Z
date_updated: 2026-04-02T14:35:31Z
day: '14'
ddc:
- '510'
- '000'
department:
- _id: HeEd
doi: 10.20382/jocg.v11i2a7
file:
- access_level: open_access
  checksum: f02d0b2b3838e7891a6c417fc34ffdcd
  content_type: application/pdf
  creator: asandaue
  date_created: 2021-08-11T11:55:11Z
  date_updated: 2021-08-11T11:55:11Z
  file_id: '9882'
  file_name: 2020_JournalOfComputationalGeometry_Edelsbrunner.pdf
  file_size: 1449234
  relation: main_file
  success: 1
file_date_updated: 2021-08-11T11:55:11Z
fulldoi: https://doi.org/10.20382/jocg.v11i2a7
has_accepted_license: '1'
intvolume: '        11'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '12'
oa: 1
oa_version: Published Version
page: 162-182
project:
- _id: 0aa4bc98-070f-11eb-9043-e6fff9c6a316
  grant_number: I4887
  name: Persistent Homology, Algorithms and Stochastic Geometry
publication: Journal of Computational Geometry
publication_identifier:
  eissn:
  - 1920-180X
publication_status: published
publisher: Carleton University
quality_controlled: '1'
scopus_import: '1'
status: public
title: Topological data analysis in information space
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 11
year: '2020'
...
---
_id: '9631'
abstract:
- lang: eng
  text: The ability to leverage large-scale hardware parallelism has been one of the
    key enablers of the accelerated recent progress in machine learning. Consequently,
    there has been considerable effort invested into developing efficient parallel
    variants of classic machine learning algorithms. However, despite the wealth of
    knowledge on parallelization, some classic machine learning algorithms often prove
    hard to parallelize efficiently while maintaining convergence. In this paper,
    we focus on efficient parallel algorithms for the key machine learning task of
    inference on graphical models, in particular on the fundamental belief propagation
    algorithm. We address the challenge of efficiently parallelizing this classic
    paradigm by showing how to leverage scalable relaxed schedulers in this context.
    We present an extensive empirical study, showing that our approach outperforms
    previous parallel belief propagation implementations both in terms of scalability
    and in terms of wall-clock convergence time, on a range of practical applications.
acknowledgement: "We thank Marco Mondelli for discussions related to LDPC decoding,
  and Giorgi Nadiradze for discussions on analysis of relaxed schedulers. This project
  has received funding from the European Research Council (ERC) under the European\r\nUnion’s
  Horizon 2020 research and innovation programme (grant agreement No 805223 ScaleML)."
alternative_title:
- Advances in Neural Information Processing Systems
article_processing_charge: No
arxiv: 1
author:
- first_name: Vitaly
  full_name: Aksenov, Vitaly
  last_name: Aksenov
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Janne
  full_name: Korhonen, Janne
  id: C5402D42-15BC-11E9-A202-CA2BE6697425
  last_name: Korhonen
citation:
  ama: 'Aksenov V, Alistarh D-A, Korhonen J. Scalable belief propagation via relaxed
    scheduling. In: Vol 33. Neural Information Processing Systems Foundation; 2020:22361-22372.'
  apa: 'Aksenov, V., Alistarh, D.-A., &#38; Korhonen, J. (2020). Scalable belief propagation
    via relaxed scheduling (Vol. 33, pp. 22361–22372). Presented at the NeurIPS: Conference
    on Neural Information Processing Systems, Vancouver, Canada: Neural Information
    Processing Systems Foundation.'
  chicago: Aksenov, Vitaly, Dan-Adrian Alistarh, and Janne Korhonen. “Scalable Belief
    Propagation via Relaxed Scheduling,” 33:22361–72. Neural Information Processing
    Systems Foundation, 2020.
  ieee: 'V. Aksenov, D.-A. Alistarh, and J. Korhonen, “Scalable belief propagation
    via relaxed scheduling,” presented at the NeurIPS: Conference on Neural Information
    Processing Systems, Vancouver, Canada, 2020, vol. 33, pp. 22361–22372.'
  ista: 'Aksenov V, Alistarh D-A, Korhonen J. 2020. Scalable belief propagation via
    relaxed scheduling. NeurIPS: Conference on Neural Information Processing Systems,
    Advances in Neural Information Processing Systems, vol. 33, 22361–22372.'
  mla: Aksenov, Vitaly, et al. <i>Scalable Belief Propagation via Relaxed Scheduling</i>.
    Vol. 33, Neural Information Processing Systems Foundation, 2020, pp. 22361–72.
  short: V. Aksenov, D.-A. Alistarh, J. Korhonen, in:, Neural Information Processing
    Systems Foundation, 2020, pp. 22361–22372.
conference:
  end_date: 2020-12-12
  location: Vancouver, Canada
  name: 'NeurIPS: Conference on Neural Information Processing Systems'
  start_date: 2020-12-06
corr_author: '1'
date_created: 2021-07-04T22:01:26Z
date_published: 2020-12-06T00:00:00Z
date_updated: 2026-06-18T19:54:53Z
day: '06'
ddc:
- '000'
department:
- _id: DaAl
ec_funded: 1
external_id:
  arxiv:
  - '2002.11505'
intvolume: '        33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://proceedings.neurips.cc/paper/2020/hash/fdb2c3bab9d0701c4a050a4d8d782c7f-Abstract.html
month: '12'
oa: 1
oa_version: Published Version
page: 22361-22372
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication_identifier:
  isbn:
  - '9781713829546'
  issn:
  - 1049-5258
publication_status: published
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scalable belief propagation via relaxed scheduling
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '9632'
abstract:
- lang: eng
  text: "Second-order information, in the form of Hessian- or Inverse-Hessian-vector
    products, is a fundamental tool for solving optimization problems. Recently, there
    has been significant interest in utilizing this information in the context of
    deep\r\nneural networks; however, relatively little is known about the quality
    of existing approximations in this context. Our work examines this question, identifies
    issues with existing approaches, and proposes a method called WoodFisher to compute
    a faithful and efficient estimate of the inverse Hessian. Our main application
    is to neural network compression, where we build on the classic Optimal Brain
    Damage/Surgeon framework. We demonstrate that WoodFisher significantly outperforms
    popular state-of-the-art methods for oneshot pruning. Further, even when iterative,
    gradual pruning is allowed, our method results in a gain in test accuracy over
    the state-of-the-art approaches, for standard image classification datasets such
    as ImageNet ILSVRC. We examine how our method can be extended to take into account
    first-order information, as well as\r\nillustrate its ability to automatically
    set layer-wise pruning thresholds and perform compression in the limited-data
    regime. The code is available at the following link, https://github.com/IST-DASLab/WoodFisher."
acknowledgement: This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement No 805223 ScaleML). Also, we would like to thank Alexander Shevchenko,
  Alexandra Peste, and other members of the group for fruitful discussions.
alternative_title:
- Advances in Neural Information Processing Systems
article_processing_charge: No
arxiv: 1
author:
- first_name: Sidak Pal
  full_name: Singh, Sidak Pal
  id: DD138E24-D89D-11E9-9DC0-DEF6E5697425
  last_name: Singh
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
citation:
  ama: 'Singh SP, Alistarh D-A. WoodFisher: Efficient second-order approximation for
    neural network compression. In: Vol 33. Neural Information Processing Systems
    Foundation; 2020:18098-18109.'
  apa: 'Singh, S. P., &#38; Alistarh, D.-A. (2020). WoodFisher: Efficient second-order
    approximation for neural network compression (Vol. 33, pp. 18098–18109). Presented
    at the NeurIPS: Conference on Neural Information Processing Systems, Vancouver,
    Canada: Neural Information Processing Systems Foundation.'
  chicago: 'Singh, Sidak Pal, and Dan-Adrian Alistarh. “WoodFisher: Efficient Second-Order
    Approximation for Neural Network Compression,” 33:18098–109. Neural Information
    Processing Systems Foundation, 2020.'
  ieee: 'S. P. Singh and D.-A. Alistarh, “WoodFisher: Efficient second-order approximation
    for neural network compression,” presented at the NeurIPS: Conference on Neural
    Information Processing Systems, Vancouver, Canada, 2020, vol. 33, pp. 18098–18109.'
  ista: 'Singh SP, Alistarh D-A. 2020. WoodFisher: Efficient second-order approximation
    for neural network compression. NeurIPS: Conference on Neural Information Processing
    Systems, Advances in Neural Information Processing Systems, vol. 33, 18098–18109.'
  mla: 'Singh, Sidak Pal, and Dan-Adrian Alistarh. <i>WoodFisher: Efficient Second-Order
    Approximation for Neural Network Compression</i>. Vol. 33, Neural Information
    Processing Systems Foundation, 2020, pp. 18098–109.'
  short: S.P. Singh, D.-A. Alistarh, in:, Neural Information Processing Systems Foundation,
    2020, pp. 18098–18109.
conference:
  end_date: 2020-12-12
  location: Vancouver, Canada
  name: 'NeurIPS: Conference on Neural Information Processing Systems'
  start_date: 2020-12-06
corr_author: '1'
date_created: 2021-07-04T22:01:26Z
date_published: 2020-12-06T00:00:00Z
date_updated: 2026-06-18T19:55:12Z
day: '06'
ddc:
- '000'
department:
- _id: DaAl
- _id: ToHe
ec_funded: 1
external_id:
  arxiv:
  - '2004.14340'
intvolume: '        33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://proceedings.neurips.cc/paper/2020/hash/d1ff1ec86b62cd5f3903ff19c3a326b2-Abstract.html
month: '12'
oa: 1
oa_version: Published Version
page: 18098-18109
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication_identifier:
  isbn:
  - '9781713829546'
  issn:
  - 1049-5258
publication_status: published
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'WoodFisher: Efficient second-order approximation for neural network compression'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '9706'
abstract:
- lang: eng
  text: 'Additional file 2: Supplementary Tables. The association of pre-adjusted
    protein levels with biological and technical covariates. Protein levels were adjusted
    for age, sex, array plate and four genetic principal components (population structure)
    prior to analyses. Significant associations are emboldened. (Table S1). pQTLs
    associated with inflammatory biomarker levels from Bayesian penalised regression
    model (Posterior Inclusion Probability > 95%). (Table S2). All pQTLs associated
    with inflammatory biomarker levels from ordinary least squares regression model
    (P < 7.14 × 10− 10). (Table S3). Summary of lambda values relating to ordinary
    least squares GWAS and EWAS performed on inflammatory protein levels (n = 70)
    in Lothian Birth Cohort 1936 study. (Table S4). Conditionally significant pQTLs
    associated with inflammatory biomarker levels from ordinary least squares regression
    model (P < 7.14 × 10− 10). (Table S5). Comparison of variance explained by ordinary
    least squares and Bayesian penalised regression models for concordantly identified
    SNPs. (Table S6). Estimate of heritability for blood protein levels as well as
    proportion of variance explained attributable to different prior mixtures. (Table
    S7). Comparison of heritability estimates from Ahsan et al. (maximum likelihood)
    and Hillary et al. (Bayesian penalised regression). (Table S8). List of concordant
    SNPs identified by linear model and Bayesian penalised regression and whether
    they have been previously identified as eQTLs. (Table S9). Bayesian tests of colocalisation
    for cis pQTLs and cis eQTLs. (Table S10). Sherlock algorithm: Genes whose expression
    are putatively associated with circulating inflammatory proteins that harbour
    pQTLs. (Table S11). CpGs associated with inflammatory protein biomarkers as identified
    by Bayesian model (Bayesian model; Posterior Inclusion Probability > 95%). (Table
    S12). CpGs associated with inflammatory protein biomarkers as identified by linear
    model (limma) at P < 5.14 × 10− 10. (Table S13). CpGs associated with inflammatory
    protein biomarkers as identified by mixed linear model (OSCA) at P < 5.14 × 10− 10.
    (Table S14). Estimate of variance explained for blood protein levels by DNA methylation
    as well as proportion of explained attributable to different prior mixtures -
    BayesR+. (Table S15). Comparison of variance in protein levels explained by genome-wide
    DNA methylation data by mixed linear model (OSCA) and Bayesian penalised regression
    model (BayesR+). (Table S16). Variance in circulating inflammatory protein biomarker
    levels explained by common genetic and methylation data (joint and conditional
    estimates from BayesR+). Ordered by combined variance explained by genetic and
    epigenetic data - smallest to largest. Significant results from t-tests comparing
    distributions for variance explained by methylation or genetics alone versus combined
    estimate are emboldened. (Table S17). Genetic and epigenetic factors identified
    by BayesR+ when conditioning on all SNPs and CpGs together. (Table S18). Mendelian
    Randomisation analyses to assess whether proteins with concordantly identified
    genetic signals are causally associated with Alzheimer’s disease risk. (Table
    S19).'
article_processing_charge: No
author:
- first_name: Robert F.
  full_name: Hillary, Robert F.
  last_name: Hillary
- first_name: Daniel
  full_name: Trejo-Banos, Daniel
  last_name: Trejo-Banos
- first_name: Athanasios
  full_name: Kousathanas, Athanasios
  last_name: Kousathanas
- first_name: Daniel L.
  full_name: McCartney, Daniel L.
  last_name: McCartney
- first_name: Sarah E.
  full_name: Harris, Sarah E.
  last_name: Harris
- first_name: Anna J.
  full_name: Stevenson, Anna J.
  last_name: Stevenson
- first_name: Marion
  full_name: Patxot, Marion
  last_name: Patxot
- first_name: Sven Erik
  full_name: Ojavee, Sven Erik
  last_name: Ojavee
- first_name: Qian
  full_name: Zhang, Qian
  last_name: Zhang
- first_name: David C.
  full_name: Liewald, David C.
  last_name: Liewald
- first_name: Craig W.
  full_name: Ritchie, Craig W.
  last_name: Ritchie
- first_name: Kathryn L.
  full_name: Evans, Kathryn L.
  last_name: Evans
- first_name: Elliot M.
  full_name: Tucker-Drob, Elliot M.
  last_name: Tucker-Drob
- first_name: Naomi R.
  full_name: Wray, Naomi R.
  last_name: Wray
- first_name: 'Allan F. '
  full_name: 'McRae, Allan F. '
  last_name: McRae
- first_name: Peter M.
  full_name: Visscher, Peter M.
  last_name: Visscher
- first_name: Ian J.
  full_name: Deary, Ian J.
  last_name: Deary
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: 'Riccardo E. '
  full_name: 'Marioni, Riccardo E. '
  last_name: Marioni
citation:
  ama: Hillary RF, Trejo-Banos D, Kousathanas A, et al. Additional file 2 of multi-method
    genome- and epigenome-wide studies of inflammatory protein levels in healthy older
    adults. 2020. doi:<a href="https://doi.org/10.6084/m9.figshare.12629697.v1">10.6084/m9.figshare.12629697.v1</a>
  apa: Hillary, R. F., Trejo-Banos, D., Kousathanas, A., McCartney, D. L., Harris,
    S. E., Stevenson, A. J., … Marioni, R. E. (2020). Additional file 2 of multi-method
    genome- and epigenome-wide studies of inflammatory protein levels in healthy older
    adults. Springer Nature. <a href="https://doi.org/10.6084/m9.figshare.12629697.v1">https://doi.org/10.6084/m9.figshare.12629697.v1</a>
  chicago: Hillary, Robert F., Daniel Trejo-Banos, Athanasios Kousathanas, Daniel
    L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, et al. “Additional
    File 2 of Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein
    Levels in Healthy Older Adults.” Springer Nature, 2020. <a href="https://doi.org/10.6084/m9.figshare.12629697.v1">https://doi.org/10.6084/m9.figshare.12629697.v1</a>.
  ieee: R. F. Hillary <i>et al.</i>, “Additional file 2 of multi-method genome- and
    epigenome-wide studies of inflammatory protein levels in healthy older adults.”
    Springer Nature, 2020.
  ista: Hillary RF, Trejo-Banos D, Kousathanas A, McCartney DL, Harris SE, Stevenson
    AJ, Patxot M, Ojavee SE, Zhang Q, Liewald DC, Ritchie CW, Evans KL, Tucker-Drob
    EM, Wray NR, McRae AF, Visscher PM, Deary IJ, Robinson MR, Marioni RE. 2020. Additional
    file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein
    levels in healthy older adults, Springer Nature, <a href="https://doi.org/10.6084/m9.figshare.12629697.v1">10.6084/m9.figshare.12629697.v1</a>.
  mla: Hillary, Robert F., et al. <i>Additional File 2 of Multi-Method Genome- and
    Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults</i>.
    Springer Nature, 2020, doi:<a href="https://doi.org/10.6084/m9.figshare.12629697.v1">10.6084/m9.figshare.12629697.v1</a>.
  short: R.F. Hillary, D. Trejo-Banos, A. Kousathanas, D.L. McCartney, S.E. Harris,
    A.J. Stevenson, M. Patxot, S.E. Ojavee, Q. Zhang, D.C. Liewald, C.W. Ritchie,
    K.L. Evans, E.M. Tucker-Drob, N.R. Wray, A.F. McRae, P.M. Visscher, I.J. Deary,
    M.R. Robinson, R.E. Marioni, (2020).
date_created: 2021-07-23T08:59:15Z
date_published: 2020-07-09T00:00:00Z
date_updated: 2026-04-02T14:28:32Z
day: '09'
department:
- _id: MaRo
doi: 10.6084/m9.figshare.12629697.v1
fulldoi: https://doi.org/10.6084/m9.figshare.12629697.v1
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.6084/m9.figshare.12629697.v1
month: '07'
oa: 1
oa_version: Published Version
other_data_license: CC0 + CC BY (4.0)
publisher: Springer Nature
related_material:
  record:
  - id: '8133'
    relation: used_in_publication
    status: public
status: public
title: Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory
  protein levels in healthy older adults
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '9708'
abstract:
- lang: eng
  text: This research data supports 'Hard antinodal gap revealed by quantum oscillations
    in the pseudogap regime of underdoped high-Tc superconductors'. A Readme file
    for plotting each figure is provided.
article_processing_charge: No
author:
- first_name: Mate
  full_name: Hartstein, Mate
  last_name: Hartstein
- first_name: Yu-Te
  full_name: Hsu, Yu-Te
  last_name: Hsu
- first_name: Kimberly A
  full_name: Modic, Kimberly A
  id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
  last_name: Modic
  orcid: 0000-0001-9760-3147
- first_name: Juan
  full_name: Porras, Juan
  last_name: Porras
- first_name: Toshinao
  full_name: Loew, Toshinao
  last_name: Loew
- first_name: Matthieu
  full_name: Le Tacon, Matthieu
  last_name: Le Tacon
- first_name: Huakun
  full_name: Zuo, Huakun
  last_name: Zuo
- first_name: Jinhua
  full_name: Wang, Jinhua
  last_name: Wang
- first_name: Zengwei
  full_name: Zhu, Zengwei
  last_name: Zhu
- first_name: Mun
  full_name: Chan, Mun
  last_name: Chan
- first_name: Ross
  full_name: McDonald, Ross
  last_name: McDonald
- first_name: Gilbert
  full_name: Lonzarich, Gilbert
  last_name: Lonzarich
- first_name: Bernhard
  full_name: Keimer, Bernhard
  last_name: Keimer
- first_name: Suchitra
  full_name: Sebastian, Suchitra
  last_name: Sebastian
- first_name: Neil
  full_name: Harrison, Neil
  last_name: Harrison
citation:
  ama: Hartstein M, Hsu Y-T, Modic KA, et al. Accompanying dataset for “Hard antinodal
    gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc
    superconductors.” 2020. doi:<a href="https://doi.org/10.17863/cam.50169">10.17863/cam.50169</a>
  apa: Hartstein, M., Hsu, Y.-T., Modic, K. A., Porras, J., Loew, T., Le Tacon, M.,
    … Harrison, N. (2020). Accompanying dataset for “Hard antinodal gap revealed by
    quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors.”
    Apollo - University of Cambridge. <a href="https://doi.org/10.17863/cam.50169">https://doi.org/10.17863/cam.50169</a>
  chicago: Hartstein, Mate, Yu-Te Hsu, Kimberly A Modic, Juan Porras, Toshinao Loew,
    Matthieu Le Tacon, Huakun Zuo, et al. “Accompanying Dataset for ‘Hard Antinodal
    Gap Revealed by Quantum Oscillations in the Pseudogap Regime of Underdoped High-Tc
    Superconductors.’” Apollo - University of Cambridge, 2020. <a href="https://doi.org/10.17863/cam.50169">https://doi.org/10.17863/cam.50169</a>.
  ieee: M. Hartstein <i>et al.</i>, “Accompanying dataset for ‘Hard antinodal gap
    revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc
    superconductors.’” Apollo - University of Cambridge, 2020.
  ista: Hartstein M, Hsu Y-T, Modic KA, Porras J, Loew T, Le Tacon M, Zuo H, Wang
    J, Zhu Z, Chan M, McDonald R, Lonzarich G, Keimer B, Sebastian S, Harrison N.
    2020. Accompanying dataset for ‘Hard antinodal gap revealed by quantum oscillations
    in the pseudogap regime of underdoped high-Tc superconductors’, Apollo - University
    of Cambridge, <a href="https://doi.org/10.17863/cam.50169">10.17863/cam.50169</a>.
  mla: Hartstein, Mate, et al. <i>Accompanying Dataset for “Hard Antinodal Gap Revealed
    by Quantum Oscillations in the Pseudogap Regime of Underdoped High-Tc Superconductors.”</i>
    Apollo - University of Cambridge, 2020, doi:<a href="https://doi.org/10.17863/cam.50169">10.17863/cam.50169</a>.
  short: M. Hartstein, Y.-T. Hsu, K.A. Modic, J. Porras, T. Loew, M. Le Tacon, H.
    Zuo, J. Wang, Z. Zhu, M. Chan, R. McDonald, G. Lonzarich, B. Keimer, S. Sebastian,
    N. Harrison, (2020).
date_created: 2021-07-23T10:00:35Z
date_published: 2020-05-29T00:00:00Z
date_updated: 2025-07-10T11:54:51Z
day: '29'
department:
- _id: KiMo
doi: 10.17863/cam.50169
fulldoi: https://doi.org/10.17863/cam.50169
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.17863/CAM.50169
month: '05'
oa: 1
oa_version: Published Version
publisher: Apollo - University of Cambridge
related_material:
  record:
  - id: '7942'
    relation: used_in_publication
    status: public
status: public
title: Accompanying dataset for 'Hard antinodal gap revealed by quantum oscillations
  in the pseudogap regime of underdoped high-Tc superconductors'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '9776'
article_processing_charge: No
author:
- first_name: Rok
  full_name: Grah, Rok
  id: 483E70DE-F248-11E8-B48F-1D18A9856A87
  last_name: Grah
  orcid: 0000-0003-2539-3560
- first_name: Tamar
  full_name: Friedlander, Tamar
  last_name: Friedlander
citation:
  ama: Grah R, Friedlander T. Supporting information. 2020. doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s001">10.1371/journal.pcbi.1007642.s001</a>
  apa: Grah, R., &#38; Friedlander, T. (2020). Supporting information. Public Library
    of Science. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s001">https://doi.org/10.1371/journal.pcbi.1007642.s001</a>
  chicago: Grah, Rok, and Tamar Friedlander. “Supporting Information.” Public Library
    of Science, 2020. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s001">https://doi.org/10.1371/journal.pcbi.1007642.s001</a>.
  ieee: R. Grah and T. Friedlander, “Supporting information.” Public Library of Science,
    2020.
  ista: Grah R, Friedlander T. 2020. Supporting information, Public Library of Science,
    <a href="https://doi.org/10.1371/journal.pcbi.1007642.s001">10.1371/journal.pcbi.1007642.s001</a>.
  mla: Grah, Rok, and Tamar Friedlander. <i>Supporting Information</i>. Public Library
    of Science, 2020, doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s001">10.1371/journal.pcbi.1007642.s001</a>.
  short: R. Grah, T. Friedlander, (2020).
date_created: 2021-08-06T07:15:04Z
date_published: 2020-02-25T00:00:00Z
date_updated: 2025-06-12T06:58:06Z
day: '25'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1007642.s001
fulldoi: https://doi.org/10.1371/journal.pcbi.1007642.s001
month: '02'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '7569'
    relation: used_in_publication
    status: public
status: public
title: Supporting information
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '9777'
article_processing_charge: No
author:
- first_name: Rok
  full_name: Grah, Rok
  id: 483E70DE-F248-11E8-B48F-1D18A9856A87
  last_name: Grah
  orcid: 0000-0003-2539-3560
- first_name: Tamar
  full_name: Friedlander, Tamar
  last_name: Friedlander
citation:
  ama: Grah R, Friedlander T. Maximizing crosstalk. 2020. doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s002">10.1371/journal.pcbi.1007642.s002</a>
  apa: Grah, R., &#38; Friedlander, T. (2020). Maximizing crosstalk. Public Library
    of Science. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s002">https://doi.org/10.1371/journal.pcbi.1007642.s002</a>
  chicago: Grah, Rok, and Tamar Friedlander. “Maximizing Crosstalk.” Public Library
    of Science, 2020. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s002">https://doi.org/10.1371/journal.pcbi.1007642.s002</a>.
  ieee: R. Grah and T. Friedlander, “Maximizing crosstalk.” Public Library of Science,
    2020.
  ista: Grah R, Friedlander T. 2020. Maximizing crosstalk, Public Library of Science,
    <a href="https://doi.org/10.1371/journal.pcbi.1007642.s002">10.1371/journal.pcbi.1007642.s002</a>.
  mla: Grah, Rok, and Tamar Friedlander. <i>Maximizing Crosstalk</i>. Public Library
    of Science, 2020, doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s002">10.1371/journal.pcbi.1007642.s002</a>.
  short: R. Grah, T. Friedlander, (2020).
date_created: 2021-08-06T07:21:51Z
date_published: 2020-02-25T00:00:00Z
date_updated: 2025-06-12T06:58:06Z
day: '25'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1007642.s002
fulldoi: https://doi.org/10.1371/journal.pcbi.1007642.s002
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1371/journal.pcbi.1007642.s002
month: '02'
oa: 1
oa_version: None
publisher: Public Library of Science
related_material:
  record:
  - id: '7569'
    relation: used_in_publication
    status: public
status: public
title: Maximizing crosstalk
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '9779'
article_processing_charge: No
author:
- first_name: Rok
  full_name: Grah, Rok
  id: 483E70DE-F248-11E8-B48F-1D18A9856A87
  last_name: Grah
  orcid: 0000-0003-2539-3560
- first_name: Tamar
  full_name: Friedlander, Tamar
  last_name: Friedlander
citation:
  ama: Grah R, Friedlander T. Distribution of crosstalk values. 2020. doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s003">10.1371/journal.pcbi.1007642.s003</a>
  apa: Grah, R., &#38; Friedlander, T. (2020). Distribution of crosstalk values. Public
    Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s003">https://doi.org/10.1371/journal.pcbi.1007642.s003</a>
  chicago: Grah, Rok, and Tamar Friedlander. “Distribution of Crosstalk Values.” Public
    Library of Science, 2020. <a href="https://doi.org/10.1371/journal.pcbi.1007642.s003">https://doi.org/10.1371/journal.pcbi.1007642.s003</a>.
  ieee: R. Grah and T. Friedlander, “Distribution of crosstalk values.” Public Library
    of Science, 2020.
  ista: Grah R, Friedlander T. 2020. Distribution of crosstalk values, Public Library
    of Science, <a href="https://doi.org/10.1371/journal.pcbi.1007642.s003">10.1371/journal.pcbi.1007642.s003</a>.
  mla: Grah, Rok, and Tamar Friedlander. <i>Distribution of Crosstalk Values</i>.
    Public Library of Science, 2020, doi:<a href="https://doi.org/10.1371/journal.pcbi.1007642.s003">10.1371/journal.pcbi.1007642.s003</a>.
  short: R. Grah, T. Friedlander, (2020).
date_created: 2021-08-06T07:24:37Z
date_published: 2020-02-25T00:00:00Z
date_updated: 2025-06-12T06:58:06Z
day: '25'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1007642.s003
fulldoi: https://doi.org/10.1371/journal.pcbi.1007642.s003
month: '02'
oa_version: Published Version
publisher: Public Library of Science
related_material:
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  - id: '7569'
    relation: used_in_publication
    status: public
status: public
title: Distribution of crosstalk values
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '9780'
abstract:
- lang: eng
  text: "PADREV : 4,4'-dimethoxy[1,1'-biphenyl]-2,2',5,5'-tetrol\r\nSpace Group: C
    2 (5), Cell: a 24.488(16)Å b 5.981(4)Å c 3.911(3)Å, α 90° β 91.47(3)° γ 90°"
article_processing_charge: No
author:
- first_name: Werner
  full_name: Schlemmer, Werner
  last_name: Schlemmer
- first_name: Philipp
  full_name: Nothdurft, Philipp
  last_name: Nothdurft
- first_name: Alina
  full_name: Petzold, Alina
  last_name: Petzold
- first_name: Gisbert
  full_name: Riess, Gisbert
  last_name: Riess
- first_name: Philipp
  full_name: Frühwirt, Philipp
  last_name: Frühwirt
- first_name: Max
  full_name: Schmallegger, Max
  last_name: Schmallegger
- first_name: Georg
  full_name: Gescheidt-Demner, Georg
  last_name: Gescheidt-Demner
- first_name: Roland
  full_name: Fischer, Roland
  last_name: Fischer
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Wolfgang
  full_name: Kern, Wolfgang
  last_name: Kern
- first_name: Stefan
  full_name: Spirk, Stefan
  last_name: Spirk
citation:
  ama: 'Schlemmer W, Nothdurft P, Petzold A, et al. CCDC 1991959: Experimental Crystal
    Structure Determination. 2020. doi:<a href="https://doi.org/10.5517/ccdc.csd.cc24vsrk">10.5517/ccdc.csd.cc24vsrk</a>'
  apa: 'Schlemmer, W., Nothdurft, P., Petzold, A., Riess, G., Frühwirt, P., Schmallegger,
    M., … Spirk, S. (2020). CCDC 1991959: Experimental Crystal Structure Determination.
    CCDC. <a href="https://doi.org/10.5517/ccdc.csd.cc24vsrk">https://doi.org/10.5517/ccdc.csd.cc24vsrk</a>'
  chicago: 'Schlemmer, Werner, Philipp Nothdurft, Alina Petzold, Gisbert Riess, Philipp
    Frühwirt, Max Schmallegger, Georg Gescheidt-Demner, et al. “CCDC 1991959: Experimental
    Crystal Structure Determination.” CCDC, 2020. <a href="https://doi.org/10.5517/ccdc.csd.cc24vsrk">https://doi.org/10.5517/ccdc.csd.cc24vsrk</a>.'
  ieee: 'W. Schlemmer <i>et al.</i>, “CCDC 1991959: Experimental Crystal Structure
    Determination.” CCDC, 2020.'
  ista: 'Schlemmer W, Nothdurft P, Petzold A, Riess G, Frühwirt P, Schmallegger M,
    Gescheidt-Demner G, Fischer R, Freunberger SA, Kern W, Spirk S. 2020. CCDC 1991959:
    Experimental Crystal Structure Determination, CCDC, <a href="https://doi.org/10.5517/ccdc.csd.cc24vsrk">10.5517/ccdc.csd.cc24vsrk</a>.'
  mla: 'Schlemmer, Werner, et al. <i>CCDC 1991959: Experimental Crystal Structure
    Determination</i>. CCDC, 2020, doi:<a href="https://doi.org/10.5517/ccdc.csd.cc24vsrk">10.5517/ccdc.csd.cc24vsrk</a>.'
  short: W. Schlemmer, P. Nothdurft, A. Petzold, G. Riess, P. Frühwirt, M. Schmallegger,
    G. Gescheidt-Demner, R. Fischer, S.A. Freunberger, W. Kern, S. Spirk, (2020).
date_created: 2021-08-06T07:41:07Z
date_published: 2020-03-22T00:00:00Z
date_updated: 2026-06-18T19:32:35Z
day: '22'
department:
- _id: StFr
doi: 10.5517/ccdc.csd.cc24vsrk
fulldoi: https://doi.org/10.5517/ccdc.csd.cc24vsrk
main_file_link:
- open_access: '1'
  url: https://dx.doi.org/10.5517/ccdc.csd.cc24vsrk
month: '03'
oa: 1
oa_version: Published Version
publisher: CCDC
related_material:
  record:
  - id: '8329'
    relation: used_in_publication
    status: public
status: public
title: 'CCDC 1991959: Experimental Crystal Structure Determination'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '9798'
abstract:
- lang: eng
  text: Fitness interactions between mutations can influence a population’s evolution
    in many different ways. While epistatic effects are difficult to measure precisely,
    important information is captured by the mean and variance of log fitnesses for
    individuals carrying different numbers of mutations. We derive predictions for
    these quantities from a class of simple fitness landscapes, based on models of
    optimizing selection on quantitative traits. We also explore extensions to the
    models, including modular pleiotropy, variable effect sizes, mutational bias and
    maladaptation of the wild type. We illustrate our approach by reanalysing a large
    dataset of mutant effects in a yeast snoRNA. Though characterized by some large
    epistatic effects, these data give a good overall fit to the non-epistatic null
    model, suggesting that epistasis might have limited influence on the evolutionary
    dynamics in this system. We also show how the amount of epistasis depends on both
    the underlying fitness landscape and the distribution of mutations, and so is
    expected to vary in consistent ways between new mutations, standing variation
    and fixed mutations.
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: John J.
  full_name: Welch, John J.
  last_name: Welch
citation:
  ama: Fraisse C, Welch JJ. Simulation code for Fig S2 from the distribution of epistasis
    on simple fitness landscapes. 2020. doi:<a href="https://doi.org/10.6084/m9.figshare.7957472.v1">10.6084/m9.figshare.7957472.v1</a>
  apa: Fraisse, C., &#38; Welch, J. J. (2020). Simulation code for Fig S2 from the
    distribution of epistasis on simple fitness landscapes. Royal Society of London.
    <a href="https://doi.org/10.6084/m9.figshare.7957472.v1">https://doi.org/10.6084/m9.figshare.7957472.v1</a>
  chicago: Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S2 from
    the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of
    London, 2020. <a href="https://doi.org/10.6084/m9.figshare.7957472.v1">https://doi.org/10.6084/m9.figshare.7957472.v1</a>.
  ieee: C. Fraisse and J. J. Welch, “Simulation code for Fig S2 from the distribution
    of epistasis on simple fitness landscapes.” Royal Society of London, 2020.
  ista: Fraisse C, Welch JJ. 2020. Simulation code for Fig S2 from the distribution
    of epistasis on simple fitness landscapes, Royal Society of London, <a href="https://doi.org/10.6084/m9.figshare.7957472.v1">10.6084/m9.figshare.7957472.v1</a>.
  mla: Fraisse, Christelle, and John J. Welch. <i>Simulation Code for Fig S2 from
    the Distribution of Epistasis on Simple Fitness Landscapes</i>. Royal Society
    of London, 2020, doi:<a href="https://doi.org/10.6084/m9.figshare.7957472.v1">10.6084/m9.figshare.7957472.v1</a>.
  short: C. Fraisse, J.J. Welch, (2020).
date_created: 2021-08-06T11:18:15Z
date_published: 2020-10-15T00:00:00Z
date_updated: 2026-06-18T19:05:02Z
day: '15'
department:
- _id: BeVi
- _id: NiBa
doi: 10.6084/m9.figshare.7957472.v1
fulldoi: https://doi.org/10.6084/m9.figshare.7957472.v1
main_file_link:
- open_access: '1'
  url: https://doi.org/10.6084/m9.figshare.7957472.v1
month: '10'
oa: 1
oa_version: Published Version
publisher: Royal Society of London
related_material:
  record:
  - id: '6467'
    relation: used_in_publication
    status: public
status: public
title: Simulation code for Fig S2 from the distribution of epistasis on simple fitness
  landscapes
type: research_data_reference
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '9799'
abstract:
- lang: eng
  text: Fitness interactions between mutations can influence a population’s evolution
    in many different ways. While epistatic effects are difficult to measure precisely,
    important information is captured by the mean and variance of log fitnesses for
    individuals carrying different numbers of mutations. We derive predictions for
    these quantities from a class of simple fitness landscapes, based on models of
    optimizing selection on quantitative traits. We also explore extensions to the
    models, including modular pleiotropy, variable effect sizes, mutational bias and
    maladaptation of the wild type. We illustrate our approach by reanalysing a large
    dataset of mutant effects in a yeast snoRNA. Though characterized by some large
    epistatic effects, these data give a good overall fit to the non-epistatic null
    model, suggesting that epistasis might have limited influence on the evolutionary
    dynamics in this system. We also show how the amount of epistasis depends on both
    the underlying fitness landscape and the distribution of mutations, and so is
    expected to vary in consistent ways between new mutations, standing variation
    and fixed mutations.
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: John J.
  full_name: Welch, John J.
  last_name: Welch
citation:
  ama: Fraisse C, Welch JJ. Simulation code for Fig S1 from the distribution of epistasis
    on simple fitness landscapes. 2020. doi:<a href="https://doi.org/10.6084/m9.figshare.7957469.v1">10.6084/m9.figshare.7957469.v1</a>
  apa: Fraisse, C., &#38; Welch, J. J. (2020). Simulation code for Fig S1 from the
    distribution of epistasis on simple fitness landscapes. Royal Society of London.
    <a href="https://doi.org/10.6084/m9.figshare.7957469.v1">https://doi.org/10.6084/m9.figshare.7957469.v1</a>
  chicago: Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S1 from
    the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of
    London, 2020. <a href="https://doi.org/10.6084/m9.figshare.7957469.v1">https://doi.org/10.6084/m9.figshare.7957469.v1</a>.
  ieee: C. Fraisse and J. J. Welch, “Simulation code for Fig S1 from the distribution
    of epistasis on simple fitness landscapes.” Royal Society of London, 2020.
  ista: Fraisse C, Welch JJ. 2020. Simulation code for Fig S1 from the distribution
    of epistasis on simple fitness landscapes, Royal Society of London, <a href="https://doi.org/10.6084/m9.figshare.7957469.v1">10.6084/m9.figshare.7957469.v1</a>.
  mla: Fraisse, Christelle, and John J. Welch. <i>Simulation Code for Fig S1 from
    the Distribution of Epistasis on Simple Fitness Landscapes</i>. Royal Society
    of London, 2020, doi:<a href="https://doi.org/10.6084/m9.figshare.7957469.v1">10.6084/m9.figshare.7957469.v1</a>.
  short: C. Fraisse, J.J. Welch, (2020).
date_created: 2021-08-06T11:26:57Z
date_published: 2020-10-15T00:00:00Z
date_updated: 2026-06-18T19:05:02Z
day: '15'
department:
- _id: BeVi
- _id: NiBa
doi: 10.6084/m9.figshare.7957469.v1
fulldoi: https://doi.org/10.6084/m9.figshare.7957469.v1
main_file_link:
- open_access: '1'
  url: https://doi.org/10.6084/m9.figshare.7957469.v1
month: '10'
oa: 1
oa_version: Published Version
publisher: Royal Society of London
related_material:
  record:
  - id: '6467'
    relation: used_in_publication
    status: public
status: public
title: Simulation code for Fig S1 from the distribution of epistasis on simple fitness
  landscapes
type: research_data_reference
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
year: '2020'
...
---
_id: '6488'
abstract:
- lang: eng
  text: We prove a central limit theorem for the difference of linear eigenvalue statistics
    of a sample covariance matrix W˜ and its minor W. We find that the fluctuation
    of this difference is much smaller than those of the individual linear statistics,
    as a consequence of the strong correlation between the eigenvalues of W˜ and W.
    Our result identifies the fluctuation of the spatial derivative of the approximate
    Gaussian field in the recent paper by Dumitru and Paquette. Unlike in a similar
    result for Wigner matrices, for sample covariance matrices, the fluctuation may
    entirely vanish.
article_number: '2050006'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Giorgio
  full_name: Cipolloni, Giorgio
  id: 42198EFA-F248-11E8-B48F-1D18A9856A87
  last_name: Cipolloni
  orcid: 0000-0002-4901-7992
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
citation:
  ama: 'Cipolloni G, Erdös L. Fluctuations for differences of linear eigenvalue statistics
    for sample covariance matrices. <i>Random Matrices: Theory and Application</i>.
    2020;9(3). doi:<a href="https://doi.org/10.1142/S2010326320500069">10.1142/S2010326320500069</a>'
  apa: 'Cipolloni, G., &#38; Erdös, L. (2020). Fluctuations for differences of linear
    eigenvalue statistics for sample covariance matrices. <i>Random Matrices: Theory
    and Application</i>. World Scientific Publishing. <a href="https://doi.org/10.1142/S2010326320500069">https://doi.org/10.1142/S2010326320500069</a>'
  chicago: 'Cipolloni, Giorgio, and László Erdös. “Fluctuations for Differences of
    Linear Eigenvalue Statistics for Sample Covariance Matrices.” <i>Random Matrices:
    Theory and Application</i>. World Scientific Publishing, 2020. <a href="https://doi.org/10.1142/S2010326320500069">https://doi.org/10.1142/S2010326320500069</a>.'
  ieee: 'G. Cipolloni and L. Erdös, “Fluctuations for differences of linear eigenvalue
    statistics for sample covariance matrices,” <i>Random Matrices: Theory and Application</i>,
    vol. 9, no. 3. World Scientific Publishing, 2020.'
  ista: 'Cipolloni G, Erdös L. 2020. Fluctuations for differences of linear eigenvalue
    statistics for sample covariance matrices. Random Matrices: Theory and Application.
    9(3), 2050006.'
  mla: 'Cipolloni, Giorgio, and László Erdös. “Fluctuations for Differences of Linear
    Eigenvalue Statistics for Sample Covariance Matrices.” <i>Random Matrices: Theory
    and Application</i>, vol. 9, no. 3, 2050006, World Scientific Publishing, 2020,
    doi:<a href="https://doi.org/10.1142/S2010326320500069">10.1142/S2010326320500069</a>.'
  short: 'G. Cipolloni, L. Erdös, Random Matrices: Theory and Application 9 (2020).'
date_created: 2019-05-26T21:59:14Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2025-07-10T11:53:26Z
day: '01'
department:
- _id: LaEr
doi: 10.1142/S2010326320500069
ec_funded: 1
external_id:
  arxiv:
  - '1806.08751'
  isi:
  - '000547464400001'
fulldoi: https://doi.org/10.1142/S2010326320500069
intvolume: '         9'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1806.08751
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: 'Random Matrices: Theory and Application'
publication_identifier:
  eissn:
  - 2010-3271
  issn:
  - 2010-3263
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fluctuations for differences of linear eigenvalue statistics for sample covariance
  matrices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2020'
...
---
_id: '6563'
abstract:
- lang: eng
  text: "This paper presents two algorithms. The first decides the existence of a
    pointed homotopy between given simplicial maps \U0001D453,\U0001D454:\U0001D44B→\U0001D44C,
    and the second computes the group [\U0001D6F4\U0001D44B,\U0001D44C]∗ of pointed
    homotopy classes of maps from a suspension; in both cases, the target Y is assumed
    simply connected. More generally, these algorithms work relative to \U0001D434⊆\U0001D44B."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marek
  full_name: Filakovský, Marek
  id: 3E8AF77E-F248-11E8-B48F-1D18A9856A87
  last_name: Filakovský
- first_name: Lukas
  full_name: Vokřínek, Lukas
  last_name: Vokřínek
citation:
  ama: Filakovský M, Vokřínek L. Are two given maps homotopic? An algorithmic viewpoint.
    <i>Foundations of Computational Mathematics</i>. 2020;20:311-330. doi:<a href="https://doi.org/10.1007/s10208-019-09419-x">10.1007/s10208-019-09419-x</a>
  apa: Filakovský, M., &#38; Vokřínek, L. (2020). Are two given maps homotopic? An
    algorithmic viewpoint. <i>Foundations of Computational Mathematics</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s10208-019-09419-x">https://doi.org/10.1007/s10208-019-09419-x</a>
  chicago: Filakovský, Marek, and Lukas Vokřínek. “Are Two given Maps Homotopic? An
    Algorithmic Viewpoint.” <i>Foundations of Computational Mathematics</i>. Springer
    Nature, 2020. <a href="https://doi.org/10.1007/s10208-019-09419-x">https://doi.org/10.1007/s10208-019-09419-x</a>.
  ieee: M. Filakovský and L. Vokřínek, “Are two given maps homotopic? An algorithmic
    viewpoint,” <i>Foundations of Computational Mathematics</i>, vol. 20. Springer
    Nature, pp. 311–330, 2020.
  ista: Filakovský M, Vokřínek L. 2020. Are two given maps homotopic? An algorithmic
    viewpoint. Foundations of Computational Mathematics. 20, 311–330.
  mla: Filakovský, Marek, and Lukas Vokřínek. “Are Two given Maps Homotopic? An Algorithmic
    Viewpoint.” <i>Foundations of Computational Mathematics</i>, vol. 20, Springer
    Nature, 2020, pp. 311–30, doi:<a href="https://doi.org/10.1007/s10208-019-09419-x">10.1007/s10208-019-09419-x</a>.
  short: M. Filakovský, L. Vokřínek, Foundations of Computational Mathematics 20 (2020)
    311–330.
date_created: 2019-06-16T21:59:14Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2025-07-10T11:53:32Z
day: '01'
department:
- _id: UlWa
doi: 10.1007/s10208-019-09419-x
external_id:
  arxiv:
  - '1312.2337'
  isi:
  - '000522437400004'
fulldoi: https://doi.org/10.1007/s10208-019-09419-x
intvolume: '        20'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1312.2337
month: '04'
oa: 1
oa_version: Preprint
page: 311-330
project:
- _id: 26611F5C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P31312
  name: Algorithms for Embeddings and Homotopy Theory
publication: Foundations of Computational Mathematics
publication_identifier:
  eissn:
  - 1615-3383
  issn:
  - 1615-3375
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Are two given maps homotopic? An algorithmic viewpoint
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2020'
...
