---
_id: '145'
abstract:
- lang: eng
  text: Aged proteins can become hazardous to cellular function, by accumulating molecular
    damage. This implies that cells should preferentially rely on newly produced ones.
    We tested this hypothesis in cultured hippocampal neurons, focusing on synaptic
    transmission. We found that newly synthesized vesicle proteins were incorporated
    in the actively recycling pool of vesicles responsible for all neurotransmitter
    release during physiological activity. We observed this for the calcium sensor
    Synaptotagmin 1, for the neurotransmitter transporter VGAT, and for the fusion
    protein VAMP2 (Synaptobrevin 2). Metabolic labeling of proteins and visualization
    by secondary ion mass spectrometry enabled us to query the entire protein makeup
    of the actively recycling vesicles, which we found to be younger than that of
    non-recycling vesicles. The young vesicle proteins remained in use for up to ~
    24 h, during which they participated in recycling a few hundred times. They were
    afterward reluctant to release and were degraded after an additional ~ 24–48 h.
    We suggest that the recycling pool of synaptic vesicles relies on newly synthesized
    proteins, while the inactive reserve pool contains older proteins.
acknowledgement: We thank Reinhard Jahn for providing a plasmid for YFP-SNAP25. We
  thank Erwin Neher for help with the development of the mathematical model of the
  synaptic vesicle life cycle. We thank Martin Meschkat, Andreas Höbartner, Annedore
  Punge, and Peer Hoopmann for help with the experiments. We thank Burkhard Rammner
  for providing the illustrations of synaptic vesicle and protein dynamics. We thank
  Manuel Maidorn, Martin Helm, and Katharina N. Richter for critically reading the
  manuscript. S.T. was supported by an Excellence Stipend of the Göttingen Graduate
  School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB). E.F.F. is
  a recipient of long-term fellowships from the European Molecular Biology Organization
  (ALTF_797-2012) and from the Human Frontier Science Program (HFSP_LT000830/2013).
  The work was supported by grants to S.O.R. from the European Research Council (ERC-2013-CoG
  NeuroMolAnatomy) and from the Deutsche Forschungsgemeinschaft (Cluster of Excellence
  Nanoscale Microscopy and Molecular Physiology of the Brain, SFB1190/P09, SFB889/A05,
  and SFB1286/A03, and DFG RI 1967 7/1). The nanoSIMS instrument was funded by the
  German Federal Ministry of Education and Research (03F0626A).
article_number: e98044
article_processing_charge: No
article_type: original
author:
- first_name: Sven M
  full_name: Truckenbrodt, Sven M
  id: 45812BD4-F248-11E8-B48F-1D18A9856A87
  last_name: Truckenbrodt
- first_name: Abhiyan
  full_name: Viplav, Abhiyan
  last_name: Viplav
- first_name: Sebsatian
  full_name: Jähne, Sebsatian
  last_name: Jähne
- first_name: Angela
  full_name: Vogts, Angela
  last_name: Vogts
- first_name: Annette
  full_name: Denker, Annette
  last_name: Denker
- first_name: Hanna
  full_name: Wildhagen, Hanna
  last_name: Wildhagen
- first_name: Eugenio
  full_name: Fornasiero, Eugenio
  last_name: Fornasiero
- first_name: Silvio
  full_name: Rizzoli, Silvio
  last_name: Rizzoli
citation:
  ama: Truckenbrodt SM, Viplav A, Jähne S, et al. Newly produced synaptic vesicle
    proteins are preferentially used in synaptic transmission. <i>The EMBO Journal</i>.
    2018;37(15). doi:<a href="https://doi.org/10.15252/embj.201798044">10.15252/embj.201798044</a>
  apa: Truckenbrodt, S. M., Viplav, A., Jähne, S., Vogts, A., Denker, A., Wildhagen,
    H., … Rizzoli, S. (2018). Newly produced synaptic vesicle proteins are preferentially
    used in synaptic transmission. <i>The EMBO Journal</i>. Wiley. <a href="https://doi.org/10.15252/embj.201798044">https://doi.org/10.15252/embj.201798044</a>
  chicago: Truckenbrodt, Sven M, Abhiyan Viplav, Sebsatian Jähne, Angela Vogts, Annette
    Denker, Hanna Wildhagen, Eugenio Fornasiero, and Silvio Rizzoli. “Newly Produced
    Synaptic Vesicle Proteins Are Preferentially Used in Synaptic Transmission.” <i>The
    EMBO Journal</i>. Wiley, 2018. <a href="https://doi.org/10.15252/embj.201798044">https://doi.org/10.15252/embj.201798044</a>.
  ieee: S. M. Truckenbrodt <i>et al.</i>, “Newly produced synaptic vesicle proteins
    are preferentially used in synaptic transmission,” <i>The EMBO Journal</i>, vol.
    37, no. 15. Wiley, 2018.
  ista: Truckenbrodt SM, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero
    E, Rizzoli S. 2018. Newly produced synaptic vesicle proteins are preferentially
    used in synaptic transmission. The EMBO Journal. 37(15), e98044.
  mla: Truckenbrodt, Sven M., et al. “Newly Produced Synaptic Vesicle Proteins Are
    Preferentially Used in Synaptic Transmission.” <i>The EMBO Journal</i>, vol. 37,
    no. 15, e98044, Wiley, 2018, doi:<a href="https://doi.org/10.15252/embj.201798044">10.15252/embj.201798044</a>.
  short: S.M. Truckenbrodt, A. Viplav, S. Jähne, A. Vogts, A. Denker, H. Wildhagen,
    E. Fornasiero, S. Rizzoli, The EMBO Journal 37 (2018).
corr_author: '1'
date_created: 2018-12-11T11:44:52Z
date_published: 2018-08-01T00:00:00Z
date_updated: 2024-10-09T20:58:32Z
day: '01'
ddc:
- '570'
department:
- _id: JoDa
doi: 10.15252/embj.201798044
external_id:
  isi:
  - '000440416900005'
  pmid:
  - '29950309'
file:
- access_level: open_access
  checksum: a540feb6c9af6aefc78de531461a8835
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T14:17:29Z
  date_updated: 2020-07-14T12:44:56Z
  file_id: '5710'
  file_name: 2018_EMBO_Truckenbrodt.pdf
  file_size: 2846470
  relation: main_file
file_date_updated: 2020-07-14T12:44:56Z
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '15'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: The EMBO Journal
publication_identifier:
  issn:
  - 0261-4189
publication_status: published
publisher: Wiley
publist_id: '7778'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Newly produced synaptic vesicle proteins are preferentially used in synaptic
  transmission
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 37
year: '2018'
...
---
_id: '146'
abstract:
- lang: eng
  text: The root cap protects the stem cell niche of angiosperm roots from damage.
    In Arabidopsis, lateral root cap (LRC) cells covering the meristematic zone are
    regularly lost through programmed cell death, while the outermost layer of the
    root cap covering the tip is repeatedly sloughed. Efficient coordination with
    stem cells producing new layers is needed to maintain a constant size of the cap.
    We present a signalling pair, the peptide IDA-LIKE1 (IDL1) and its receptor HAESA-LIKE2
    (HSL2), mediating such communication. Live imaging over several days characterized
    this process from initial fractures in LRC cell files to full separation of a
    layer. Enhanced expression of IDL1 in the separating root cap layers resulted
    in increased frequency of sloughing, balanced with generation of new layers in
    a HSL2-dependent manner. Transcriptome analyses linked IDL1-HSL2 signalling to
    the transcription factors BEARSKIN1/2 and genes associated with programmed cell
    death. Mutations in either IDL1 or HSL2 slowed down cell division, maturation
    and separation. Thus, IDL1-HSL2 signalling potentiates dynamic regulation of the
    homeostatic balance between stem cell division and sloughing activity.
article_processing_charge: No
article_type: original
author:
- first_name: Chun Lin
  full_name: Shi, Chun Lin
  last_name: Shi
- first_name: Daniel
  full_name: Von Wangenheim, Daniel
  id: 49E91952-F248-11E8-B48F-1D18A9856A87
  last_name: Von Wangenheim
  orcid: 0000-0002-6862-1247
- first_name: Ullrich
  full_name: Herrmann, Ullrich
  last_name: Herrmann
- first_name: Mari
  full_name: Wildhagen, Mari
  last_name: Wildhagen
- first_name: Ivan
  full_name: Kulik, Ivan
  id: F0AB3FCE-02D1-11E9-BD0E-99399A5D3DEB
  last_name: Kulik
- first_name: Andreas
  full_name: Kopf, Andreas
  last_name: Kopf
- first_name: Takashi
  full_name: Ishida, Takashi
  last_name: Ishida
- first_name: Vilde
  full_name: Olsson, Vilde
  last_name: Olsson
- first_name: Mari Kristine
  full_name: Anker, Mari Kristine
  last_name: Anker
- first_name: Markus
  full_name: Albert, Markus
  last_name: Albert
- first_name: Melinka A
  full_name: Butenko, Melinka A
  last_name: Butenko
- first_name: Georg
  full_name: Felix, Georg
  last_name: Felix
- first_name: Shinichiro
  full_name: Sawa, Shinichiro
  last_name: Sawa
- first_name: Manfred
  full_name: Claassen, Manfred
  last_name: Claassen
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Reidunn B
  full_name: Aalen, Reidunn B
  last_name: Aalen
citation:
  ama: Shi CL, von Wangenheim D, Herrmann U, et al. The dynamics of root cap sloughing
    in Arabidopsis is regulated by peptide signalling. <i>Nature Plants</i>. 2018;4(8):596-604.
    doi:<a href="https://doi.org/10.1038/s41477-018-0212-z">10.1038/s41477-018-0212-z</a>
  apa: Shi, C. L., von Wangenheim, D., Herrmann, U., Wildhagen, M., Kulik, I., Kopf,
    A., … Aalen, R. B. (2018). The dynamics of root cap sloughing in Arabidopsis is
    regulated by peptide signalling. <i>Nature Plants</i>. Nature Publishing Group.
    <a href="https://doi.org/10.1038/s41477-018-0212-z">https://doi.org/10.1038/s41477-018-0212-z</a>
  chicago: Shi, Chun Lin, Daniel von Wangenheim, Ullrich Herrmann, Mari Wildhagen,
    Ivan Kulik, Andreas Kopf, Takashi Ishida, et al. “The Dynamics of Root Cap Sloughing
    in Arabidopsis Is Regulated by Peptide Signalling.” <i>Nature Plants</i>. Nature
    Publishing Group, 2018. <a href="https://doi.org/10.1038/s41477-018-0212-z">https://doi.org/10.1038/s41477-018-0212-z</a>.
  ieee: C. L. Shi <i>et al.</i>, “The dynamics of root cap sloughing in Arabidopsis
    is regulated by peptide signalling,” <i>Nature Plants</i>, vol. 4, no. 8. Nature
    Publishing Group, pp. 596–604, 2018.
  ista: Shi CL, von Wangenheim D, Herrmann U, Wildhagen M, Kulik I, Kopf A, Ishida
    T, Olsson V, Anker MK, Albert M, Butenko MA, Felix G, Sawa S, Claassen M, Friml
    J, Aalen RB. 2018. The dynamics of root cap sloughing in Arabidopsis is regulated
    by peptide signalling. Nature Plants. 4(8), 596–604.
  mla: Shi, Chun Lin, et al. “The Dynamics of Root Cap Sloughing in Arabidopsis Is
    Regulated by Peptide Signalling.” <i>Nature Plants</i>, vol. 4, no. 8, Nature
    Publishing Group, 2018, pp. 596–604, doi:<a href="https://doi.org/10.1038/s41477-018-0212-z">10.1038/s41477-018-0212-z</a>.
  short: C.L. Shi, D. von Wangenheim, U. Herrmann, M. Wildhagen, I. Kulik, A. Kopf,
    T. Ishida, V. Olsson, M.K. Anker, M. Albert, M.A. Butenko, G. Felix, S. Sawa,
    M. Claassen, J. Friml, R.B. Aalen, Nature Plants 4 (2018) 596–604.
date_created: 2018-12-11T11:44:52Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2023-09-19T10:08:45Z
day: '30'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41477-018-0212-z
external_id:
  isi:
  - '000443861300016'
  pmid:
  - '30061750'
file:
- access_level: open_access
  checksum: da33101c76ee1b2dc5ab28fd2ccba9d0
  content_type: application/pdf
  creator: dernst
  date_created: 2019-11-18T16:24:07Z
  date_updated: 2020-07-14T12:44:56Z
  file_id: '7043'
  file_name: 2018_NaturePlants_Shi.pdf
  file_size: 226829
  relation: main_file
file_date_updated: 2020-07-14T12:44:56Z
has_accepted_license: '1'
intvolume: '         4'
isi: 1
issue: '8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 596 - 604
pmid: 1
publication: Nature Plants
publication_status: published
publisher: Nature Publishing Group
publist_id: '7777'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/new-process-in-root-development-discovered/
scopus_import: '1'
status: public
title: The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 4
year: '2018'
...
---
_id: '147'
abstract:
- lang: eng
  text: The trafficking of subcellular cargos in eukaryotic cells crucially depends
    on vesicle budding, a process mediated by ARF-GEFs (ADP-ribosylation factor guanine
    nucleotide exchange factors). In plants, ARF-GEFs play essential roles in endocytosis,
    vacuolar trafficking, recycling, secretion, and polar trafficking. Moreover, they
    are important for plant development, mainly through controlling the polar subcellular
    localization of PIN-FORMED (PIN) transporters of the plant hormone auxin. Here,
    using a chemical genetics screen in Arabidopsis thaliana, we identified Endosidin
    4 (ES4), an inhibitor of eukaryotic ARF-GEFs. ES4 acts similarly to and synergistically
    with the established ARF-GEF inhibitor Brefeldin A and has broad effects on intracellular
    trafficking, including endocytosis, exocytosis, and vacuolar targeting. Additionally,
    Arabidopsis and yeast (Sacharomyces cerevisiae) mutants defective in ARF-GEF show
    altered sensitivity to ES4. ES4 interferes with the activation-based membrane
    association of the ARF1 GTPases, but not of their mutant variants that are activated
    independently of ARF-GEF activity. Biochemical approaches and docking simulations
    confirmed that ES4 specifically targets the SEC7 domain-containing ARF-GEFs. These
    observations collectively identify ES4 as a chemical tool enabling the study of
    ARF-GEF-mediated processes, including ARF-GEF-mediated plant development.
acknowledgement: We thank Gerd Jürgens, Sandra Richter, and Sheng Yang He for providing
  antibodies; Maciek Adamowski, Fernando Aniento, Sebastian Bednarek, Nico Callewaert,
  Matyás Fendrych, Elena Feraru, and Mugurel I. Feraru for helpful suggestions; Siamsa
  Doyle for critical reading of the manuscript and helpful comments and suggestions;
  and Stephanie Smith and Martine De Cock for help in editing and language corrections.
  We acknowledge the core facility Cellular Imaging of CEITEC supported by the Czech-BioImaging
  large RI project (LM2015062 funded by MEYS CR) for their support with obtaining
  scientific data presented in this article. Plant Sciences Core Facility of CEITEC
  Masaryk University is gratefully acknowledged for obtaining part of the scientific
  data presented in this article. We acknowledge support from the Fondation pour la
  Recherche Médicale and from the Institut National du Cancer (J.C.). The research
  leading to these results was funded by the European Research Council under the European
  Union's 7th Framework Program (FP7/2007-2013)/ERC grant agreement numbers 282300
  and 742985 and the Czech Science Foundation GAČR (GA18-26981S; J.F.); Ministry of
  Education, Youth, and Sports/MEYS of the Czech Republic under the Project CEITEC
  2020 (LQ1601; T.N.); the China Science Council for a predoctoral fellowship (Q.L.);
  a joint research project within the framework of cooperation between the Research
  Foundation-Flanders and the Bulgarian Academy of Sciences (VS.025.13N; K.M. and
  E.R.); Vetenskapsrådet and Vinnova (Verket för Innovationssystem; S.R.), Knut och
  Alice Wallenbergs Stiftelse via “Shapesystem” Grant 2012.0050 (S.R.), Kempe stiftelserna
  (P.G.), Tryggers CTS410 (P.G.).
article_processing_charge: No
article_type: original
author:
- first_name: Urszula
  full_name: Kania, Urszula
  id: 4AE5C486-F248-11E8-B48F-1D18A9856A87
  last_name: Kania
- first_name: Tomasz
  full_name: Nodzyński, Tomasz
  last_name: Nodzyński
- first_name: Qing
  full_name: Lu, Qing
  last_name: Lu
- first_name: Glenn R
  full_name: Hicks, Glenn R
  last_name: Hicks
- first_name: Wim
  full_name: Nerinckx, Wim
  last_name: Nerinckx
- first_name: Kiril
  full_name: Mishev, Kiril
  last_name: Mishev
- first_name: Francois
  full_name: Peurois, Francois
  last_name: Peurois
- first_name: Jacqueline
  full_name: Cherfils, Jacqueline
  last_name: Cherfils
- first_name: Rycke Riet Maria
  full_name: De, Rycke Riet Maria
  last_name: De
- first_name: Peter
  full_name: Grones, Peter
  id: 399876EC-F248-11E8-B48F-1D18A9856A87
  last_name: Grones
- first_name: Stéphanie
  full_name: Robert, Stéphanie
  last_name: Robert
- first_name: Eugenia
  full_name: Russinova, Eugenia
  last_name: Russinova
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Kania U, Nodzyński T, Lu Q, et al. The inhibitor Endosidin 4 targets SEC7 domain-type
    ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes.
    <i>The Plant Cell</i>. 2018;30(10):2553-2572. doi:<a href="https://doi.org/10.1105/tpc.18.00127">10.1105/tpc.18.00127</a>
  apa: Kania, U., Nodzyński, T., Lu, Q., Hicks, G. R., Nerinckx, W., Mishev, K., …
    Friml, J. (2018). The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase
    exchange factors and interferes with sub cellular trafficking in eukaryotes. <i>The
    Plant Cell</i>. Oxford University Press. <a href="https://doi.org/10.1105/tpc.18.00127">https://doi.org/10.1105/tpc.18.00127</a>
  chicago: Kania, Urszula, Tomasz Nodzyński, Qing Lu, Glenn R Hicks, Wim Nerinckx,
    Kiril Mishev, Francois Peurois, et al. “The Inhibitor Endosidin 4 Targets SEC7
    Domain-Type ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking
    in Eukaryotes.” <i>The Plant Cell</i>. Oxford University Press, 2018. <a href="https://doi.org/10.1105/tpc.18.00127">https://doi.org/10.1105/tpc.18.00127</a>.
  ieee: U. Kania <i>et al.</i>, “The inhibitor Endosidin 4 targets SEC7 domain-type
    ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes,”
    <i>The Plant Cell</i>, vol. 30, no. 10. Oxford University Press, pp. 2553–2572,
    2018.
  ista: Kania U, Nodzyński T, Lu Q, Hicks GR, Nerinckx W, Mishev K, Peurois F, Cherfils
    J, De RRM, Grones P, Robert S, Russinova E, Friml J. 2018. The inhibitor Endosidin
    4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub
    cellular trafficking in eukaryotes. The Plant Cell. 30(10), 2553–2572.
  mla: Kania, Urszula, et al. “The Inhibitor Endosidin 4 Targets SEC7 Domain-Type
    ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking in Eukaryotes.”
    <i>The Plant Cell</i>, vol. 30, no. 10, Oxford University Press, 2018, pp. 2553–72,
    doi:<a href="https://doi.org/10.1105/tpc.18.00127">10.1105/tpc.18.00127</a>.
  short: U. Kania, T. Nodzyński, Q. Lu, G.R. Hicks, W. Nerinckx, K. Mishev, F. Peurois,
    J. Cherfils, R.R.M. De, P. Grones, S. Robert, E. Russinova, J. Friml, The Plant
    Cell 30 (2018) 2553–2572.
corr_author: '1'
date_created: 2018-12-11T11:44:52Z
date_published: 2018-11-12T00:00:00Z
date_updated: 2025-04-14T07:45:02Z
day: '12'
department:
- _id: JiFr
doi: 10.1105/tpc.18.00127
ec_funded: 1
external_id:
  isi:
  - '000450000500023'
  pmid:
  - '30018156'
intvolume: '        30'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1105/tpc.18.00127
month: '11'
oa: 1
oa_version: Published Version
page: 2553 - 2572
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: The Plant Cell
publication_identifier:
  issn:
  - 1040-4651
publication_status: published
publisher: Oxford University Press
publist_id: '7776'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors
  and interferes with sub cellular trafficking in eukaryotes
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2018'
...
---
_id: '18'
abstract:
- lang: eng
  text: An N-superconcentrator is a directed, acyclic graph with N input nodes and
    N output nodes such that every subset of the inputs and every subset of the outputs
    of same cardinality can be connected by node-disjoint paths. It is known that
    linear-size and bounded-degree superconcentrators exist. We prove the existence
    of such superconcentrators with asymptotic density 25.3 (where the density is
    the number of edges divided by N). The previously best known densities were 28
    [12] and 27.4136 [17].
article_processing_charge: No
arxiv: 1
author:
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
- first_name: Michal
  full_name: Rolinek, Michal
  id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
  last_name: Rolinek
citation:
  ama: Kolmogorov V, Rolinek M. Superconcentrators of density 25.3. <i>Ars Combinatoria</i>.
    2018;141(10):269-304.
  apa: Kolmogorov, V., &#38; Rolinek, M. (2018). Superconcentrators of density 25.3.
    <i>Ars Combinatoria</i>. Charles Babbage Research Centre.
  chicago: Kolmogorov, Vladimir, and Michal Rolinek. “Superconcentrators of Density
    25.3.” <i>Ars Combinatoria</i>. Charles Babbage Research Centre, 2018.
  ieee: V. Kolmogorov and M. Rolinek, “Superconcentrators of density 25.3,” <i>Ars
    Combinatoria</i>, vol. 141, no. 10. Charles Babbage Research Centre, pp. 269–304,
    2018.
  ista: Kolmogorov V, Rolinek M. 2018. Superconcentrators of density 25.3. Ars Combinatoria.
    141(10), 269–304.
  mla: Kolmogorov, Vladimir, and Michal Rolinek. “Superconcentrators of Density 25.3.”
    <i>Ars Combinatoria</i>, vol. 141, no. 10, Charles Babbage Research Centre, 2018,
    pp. 269–304.
  short: V. Kolmogorov, M. Rolinek, Ars Combinatoria 141 (2018) 269–304.
date_created: 2018-12-11T11:44:11Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2023-09-19T14:46:18Z
day: '01'
department:
- _id: VlKo
external_id:
  arxiv:
  - '1405.7828'
  isi:
  - '000446809500022'
intvolume: '       141'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1405.7828
month: '10'
oa: 1
oa_version: Preprint
page: 269 - 304
publication: Ars Combinatoria
publication_identifier:
  issn:
  - 0381-7032
publication_status: published
publisher: Charles Babbage Research Centre
publist_id: '8037'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superconcentrators of density 25.3
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 141
year: '2018'
...
---
_id: '180'
abstract:
- lang: eng
  text: In this paper we define and study the classical Uniform Electron Gas (UEG),
    a system of infinitely many electrons whose density is constant everywhere in
    space. The UEG is defined differently from Jellium, which has a positive constant
    background but no constraint on the density. We prove that the UEG arises in Density
    Functional Theory in the limit of a slowly varying density, minimizing the indirect
    Coulomb energy. We also construct the quantum UEG and compare it to the classical
    UEG at low density.
acknowledgement: "This project has received funding from the European Research Council
  (ERC) under the European\r\nUnion’s Horizon 2020 research and innovation programme
  (grant agreement 694227 for R.S. and MDFT 725528 for M.L.). Financial support by
  the Austrian Science Fund (FWF), project No P 27533-N27 (R.S.) and by the US National
  Science Foundation, grant No PHY12-1265118 (E.H.L.) are gratefully acknowledged."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Mathieu
  full_name: Lewi, Mathieu
  last_name: Lewi
- first_name: Élliott
  full_name: Lieb, Élliott
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Lewi M, Lieb É, Seiringer R. Statistical mechanics of the uniform electron
    gas. <i>Journal de l’Ecole Polytechnique - Mathematiques</i>. 2018;5:79-116. doi:<a
    href="https://doi.org/10.5802/jep.64">10.5802/jep.64</a>
  apa: Lewi, M., Lieb, É., &#38; Seiringer, R. (2018). Statistical mechanics of the
    uniform electron gas. <i>Journal de l’Ecole Polytechnique - Mathematiques</i>.
    Ecole Polytechnique. <a href="https://doi.org/10.5802/jep.64">https://doi.org/10.5802/jep.64</a>
  chicago: Lewi, Mathieu, Élliott Lieb, and Robert Seiringer. “Statistical Mechanics
    of the Uniform Electron Gas.” <i>Journal de l’Ecole Polytechnique - Mathematiques</i>.
    Ecole Polytechnique, 2018. <a href="https://doi.org/10.5802/jep.64">https://doi.org/10.5802/jep.64</a>.
  ieee: M. Lewi, É. Lieb, and R. Seiringer, “Statistical mechanics of the uniform
    electron gas,” <i>Journal de l’Ecole Polytechnique - Mathematiques</i>, vol. 5.
    Ecole Polytechnique, pp. 79–116, 2018.
  ista: Lewi M, Lieb É, Seiringer R. 2018. Statistical mechanics of the uniform electron
    gas. Journal de l’Ecole Polytechnique - Mathematiques. 5, 79–116.
  mla: Lewi, Mathieu, et al. “Statistical Mechanics of the Uniform Electron Gas.”
    <i>Journal de l’Ecole Polytechnique - Mathematiques</i>, vol. 5, Ecole Polytechnique,
    2018, pp. 79–116, doi:<a href="https://doi.org/10.5802/jep.64">10.5802/jep.64</a>.
  short: M. Lewi, É. Lieb, R. Seiringer, Journal de l’Ecole Polytechnique - Mathematiques
    5 (2018) 79–116.
date_created: 2018-12-11T11:45:03Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2025-04-14T07:26:59Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.5802/jep.64
ec_funded: 1
external_id:
  arxiv:
  - '1705.10676'
file:
- access_level: open_access
  checksum: 1ba7cccdf3900f42c4f715ae75d6813c
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:38:18Z
  date_updated: 2020-07-14T12:45:16Z
  file_id: '5726'
  file_name: 2018_JournaldeLecoleMath_Lewi.pdf
  file_size: 843938
  relation: main_file
file_date_updated: 2020-07-14T12:45:16Z
has_accepted_license: '1'
intvolume: '         5'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 79 - 116
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P27533_N27
  name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication: Journal de l'Ecole Polytechnique - Mathematiques
publication_identifier:
  eissn:
  - 2270-518X
  issn:
  - 2429-7100
publication_status: published
publisher: Ecole Polytechnique
publist_id: '7741'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical mechanics of the uniform electron gas
tmp:
  image: /image/cc_by_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
  name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
  short: CC BY-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2018'
...
---
_id: '181'
abstract:
- lang: eng
  text: We consider large random matrices X with centered, independent entries but
    possibly di erent variances. We compute the normalized trace of f(X)g(X∗) for
    f, g functions analytic on the spectrum of X. We use these results to compute
    the long time asymptotics for systems of coupled di erential equations with random
    coe cients. We show that when the coupling is critical, the norm squared of the
    solution decays like t−1/2.
acknowledgement: The work of the second author was also partially supported by the
  Hausdorff Center of Mathematics.
article_processing_charge: No
arxiv: 1
author:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Torben H
  full_name: Krüger, Torben H
  id: 3020C786-F248-11E8-B48F-1D18A9856A87
  last_name: Krüger
  orcid: 0000-0002-4821-3297
- first_name: David T
  full_name: Renfrew, David T
  id: 4845BF6A-F248-11E8-B48F-1D18A9856A87
  last_name: Renfrew
  orcid: 0000-0003-3493-121X
citation:
  ama: Erdös L, Krüger TH, Renfrew DT. Power law decay for systems of randomly coupled
    differential equations. <i>SIAM Journal on Mathematical Analysis</i>. 2018;50(3):3271-3290.
    doi:<a href="https://doi.org/10.1137/17M1143125">10.1137/17M1143125</a>
  apa: Erdös, L., Krüger, T. H., &#38; Renfrew, D. T. (2018). Power law decay for
    systems of randomly coupled differential equations. <i>SIAM Journal on Mathematical
    Analysis</i>. Society for Industrial and Applied Mathematics . <a href="https://doi.org/10.1137/17M1143125">https://doi.org/10.1137/17M1143125</a>
  chicago: Erdös, László, Torben H Krüger, and David T Renfrew. “Power Law Decay for
    Systems of Randomly Coupled Differential Equations.” <i>SIAM Journal on Mathematical
    Analysis</i>. Society for Industrial and Applied Mathematics , 2018. <a href="https://doi.org/10.1137/17M1143125">https://doi.org/10.1137/17M1143125</a>.
  ieee: L. Erdös, T. H. Krüger, and D. T. Renfrew, “Power law decay for systems of
    randomly coupled differential equations,” <i>SIAM Journal on Mathematical Analysis</i>,
    vol. 50, no. 3. Society for Industrial and Applied Mathematics , pp. 3271–3290,
    2018.
  ista: Erdös L, Krüger TH, Renfrew DT. 2018. Power law decay for systems of randomly
    coupled differential equations. SIAM Journal on Mathematical Analysis. 50(3),
    3271–3290.
  mla: Erdös, László, et al. “Power Law Decay for Systems of Randomly Coupled Differential
    Equations.” <i>SIAM Journal on Mathematical Analysis</i>, vol. 50, no. 3, Society
    for Industrial and Applied Mathematics , 2018, pp. 3271–90, doi:<a href="https://doi.org/10.1137/17M1143125">10.1137/17M1143125</a>.
  short: L. Erdös, T.H. Krüger, D.T. Renfrew, SIAM Journal on Mathematical Analysis
    50 (2018) 3271–3290.
date_created: 2018-12-11T11:45:03Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2025-04-15T08:05:02Z
day: '01'
department:
- _id: LaEr
doi: 10.1137/17M1143125
ec_funded: 1
external_id:
  arxiv:
  - '1708.01546'
  isi:
  - '000437018500032'
intvolume: '        50'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1708.01546
month: '01'
oa: 1
oa_version: Published Version
page: 3271 - 3290
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
- _id: 258F40A4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02080
  name: Structured Non-Hermitian Random Matrices
publication: SIAM Journal on Mathematical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '7740'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Power law decay for systems of randomly coupled differential equations
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 50
year: '2018'
...
---
_id: '182'
abstract:
- lang: eng
  text: We describe a new algorithm for the parametric identification problem for
    signal temporal logic (STL), stated as follows. Given a densetime real-valued
    signal w and a parameterized temporal logic formula φ, compute the subset of the
    parameter space that renders the formula satisfied by the signal. Unlike previous
    solutions, which were based on search in the parameter space or quantifier elimination,
    our procedure works recursively on φ and computes the evolution over time of the
    set of valid parameter assignments. This procedure is similar to that of monitoring
    or computing the robustness of φ relative to w. Our implementation and experiments
    demonstrate that this approach can work well in practice.
alternative_title:
- HSCC Proceedings
article_processing_charge: No
author:
- first_name: Alexey
  full_name: Bakhirkin, Alexey
  last_name: Bakhirkin
- first_name: Thomas
  full_name: Ferrere, Thomas
  id: 40960E6E-F248-11E8-B48F-1D18A9856A87
  last_name: Ferrere
  orcid: 0000-0001-5199-3143
- first_name: Oded
  full_name: Maler, Oded
  last_name: Maler
citation:
  ama: 'Bakhirkin A, Ferrere T, Maler O. Efficient parametric identification for STL.
    In: <i>Proceedings of the 21st International Conference on Hybrid Systems</i>.
    ACM; 2018:177-186. doi:<a href="https://doi.org/10.1145/3178126.3178132">10.1145/3178126.3178132</a>'
  apa: 'Bakhirkin, A., Ferrere, T., &#38; Maler, O. (2018). Efficient parametric identification
    for STL. In <i>Proceedings of the 21st International Conference on Hybrid Systems</i>
    (pp. 177–186). Porto, Portugal: ACM. <a href="https://doi.org/10.1145/3178126.3178132">https://doi.org/10.1145/3178126.3178132</a>'
  chicago: Bakhirkin, Alexey, Thomas Ferrere, and Oded Maler. “Efficient Parametric
    Identification for STL.” In <i>Proceedings of the 21st International Conference
    on Hybrid Systems</i>, 177–86. ACM, 2018. <a href="https://doi.org/10.1145/3178126.3178132">https://doi.org/10.1145/3178126.3178132</a>.
  ieee: A. Bakhirkin, T. Ferrere, and O. Maler, “Efficient parametric identification
    for STL,” in <i>Proceedings of the 21st International Conference on Hybrid Systems</i>,
    Porto, Portugal, 2018, pp. 177–186.
  ista: 'Bakhirkin A, Ferrere T, Maler O. 2018. Efficient parametric identification
    for STL. Proceedings of the 21st International Conference on Hybrid Systems. HSCC:
    Hybrid Systems - Computation and Control, HSCC Proceedings, , 177–186.'
  mla: Bakhirkin, Alexey, et al. “Efficient Parametric Identification for STL.” <i>Proceedings
    of the 21st International Conference on Hybrid Systems</i>, ACM, 2018, pp. 177–86,
    doi:<a href="https://doi.org/10.1145/3178126.3178132">10.1145/3178126.3178132</a>.
  short: A. Bakhirkin, T. Ferrere, O. Maler, in:, Proceedings of the 21st International
    Conference on Hybrid Systems, ACM, 2018, pp. 177–186.
conference:
  end_date: 2018-04-13
  location: Porto, Portugal
  name: 'HSCC: Hybrid Systems - Computation and Control'
  start_date: 2018-04-11
date_created: 2018-12-11T11:45:04Z
date_published: 2018-04-11T00:00:00Z
date_updated: 2025-07-10T11:51:21Z
day: '11'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1145/3178126.3178132
external_id:
  isi:
  - '000474781600020'
file:
- access_level: open_access
  checksum: 81eabc96430e84336ea88310ac0a1ad0
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-14T12:18:29Z
  date_updated: 2020-07-14T12:45:17Z
  file_id: '7833'
  file_name: 2018_HSCC_Bakhirkin.pdf
  file_size: 5900421
  relation: main_file
file_date_updated: 2020-07-14T12:45:17Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 177 - 186
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication: Proceedings of the 21st International Conference on Hybrid Systems
publication_identifier:
  isbn:
  - '978-1-4503-5642-8 '
publication_status: published
publisher: ACM
publist_id: '7739'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient parametric identification for STL
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '183'
abstract:
- lang: eng
  text: 'Fault-localization is considered to be a very tedious and time-consuming
    activity in the design of complex Cyber-Physical Systems (CPS). This laborious
    task essentially requires expert knowledge of the system in order to discover
    the cause of the fault. In this context, we propose a new procedure that AIDS
    designers in debugging Simulink/Stateflow hybrid system models, guided by Signal
    Temporal Logic (STL) specifications. The proposed method relies on three main
    ingredients: (1) a monitoring and a trace diagnostics procedure that checks whether
    a tested behavior satisfies or violates an STL specification, localizes time segments
    and interfaces variables contributing to the property violations; (2) a slicing
    procedure that maps these observable behavior segments to the internal states
    and transitions of the Simulink model; and (3) a spectrum-based fault-localization
    method that combines the previous analysis from multiple tests to identify the
    internal states and/or transitions that are the most likely to explain the fault.
    We demonstrate the applicability of our approach on two Simulink models from the
    automotive and the avionics domain.'
acknowledgement: This work was partially supported by the Austrian Science Fund (FWF)
  under grants S11402-N23 and S11405-N23 (RiSE/SHiNE), the CPS/IoT project (HRSM),
  the EU ICT COST Action IC1402 on Run-time Verification beyond Monitoring (ARVI),
  the AMASS project (ECSEL 692474), and the ENABLE-S3 project (ECSEL 692455). The
  CPS/IoT project receives support from the Austrian government through the Federal
  Ministry of Science, Research and Economy (BMWFW) in the funding program Hochschulraum-Strukturmittel
  (HRSM) 2016. The ECSEL Joint Undertaking receives support from the European Union’s
  Horizon 2020 research and innovation programme and Austria, Denmark, Germany, Finland,
  Czech Republic, Italy, Spain, Portugal, Poland, Ireland, Belgium, France, Netherlands,
  United Kingdom, Slovakia, Norway.
alternative_title:
- HSCC Proceedings
article_processing_charge: No
author:
- first_name: Ezio
  full_name: Bartocci, Ezio
  last_name: Bartocci
- first_name: Thomas
  full_name: Ferrere, Thomas
  id: 40960E6E-F248-11E8-B48F-1D18A9856A87
  last_name: Ferrere
  orcid: 0000-0001-5199-3143
- first_name: Niveditha
  full_name: Manjunath, Niveditha
  last_name: Manjunath
- first_name: Dejan
  full_name: Nickovic, Dejan
  last_name: Nickovic
citation:
  ama: 'Bartocci E, Ferrere T, Manjunath N, Nickovic D. Localizing faults in simulink/stateflow
    models with STL. In: Association for Computing Machinery; 2018:197-206. doi:<a
    href="https://doi.org/10.1145/3178126.3178131">10.1145/3178126.3178131</a>'
  apa: 'Bartocci, E., Ferrere, T., Manjunath, N., &#38; Nickovic, D. (2018). Localizing
    faults in simulink/stateflow models with STL (pp. 197–206). Presented at the HSCC:
    Hybrid Systems - Computation and Control, Porto, Portugal: Association for Computing
    Machinery. <a href="https://doi.org/10.1145/3178126.3178131">https://doi.org/10.1145/3178126.3178131</a>'
  chicago: Bartocci, Ezio, Thomas Ferrere, Niveditha Manjunath, and Dejan Nickovic.
    “Localizing Faults in Simulink/Stateflow Models with STL,” 197–206. Association
    for Computing Machinery, 2018. <a href="https://doi.org/10.1145/3178126.3178131">https://doi.org/10.1145/3178126.3178131</a>.
  ieee: 'E. Bartocci, T. Ferrere, N. Manjunath, and D. Nickovic, “Localizing faults
    in simulink/stateflow models with STL,” presented at the HSCC: Hybrid Systems
    - Computation and Control, Porto, Portugal, 2018, pp. 197–206.'
  ista: 'Bartocci E, Ferrere T, Manjunath N, Nickovic D. 2018. Localizing faults in
    simulink/stateflow models with STL. HSCC: Hybrid Systems - Computation and Control,
    HSCC Proceedings, , 197–206.'
  mla: Bartocci, Ezio, et al. <i>Localizing Faults in Simulink/Stateflow Models with
    STL</i>. Association for Computing Machinery, 2018, pp. 197–206, doi:<a href="https://doi.org/10.1145/3178126.3178131">10.1145/3178126.3178131</a>.
  short: E. Bartocci, T. Ferrere, N. Manjunath, D. Nickovic, in:, Association for
    Computing Machinery, 2018, pp. 197–206.
conference:
  end_date: 2018-04-13
  location: Porto, Portugal
  name: 'HSCC: Hybrid Systems - Computation and Control'
  start_date: 2018-04-11
date_created: 2018-12-11T11:45:04Z
date_published: 2018-04-11T00:00:00Z
date_updated: 2025-07-10T11:51:22Z
day: '11'
department:
- _id: ToHe
doi: 10.1145/3178126.3178131
external_id:
  isi:
  - '000474781600022'
isi: 1
language:
- iso: eng
month: '04'
oa_version: None
page: 197 - 206
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Association for Computing Machinery
publist_id: '7738'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localizing faults in simulink/stateflow models with STL
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '184'
abstract:
- lang: eng
  text: We prove that for every d ≥ 2, deciding if a pure, d-dimensional, simplicial
    complex is shellable is NP-hard, hence NP-complete. This resolves a question raised,
    e.g., by Danaraj and Klee in 1978. Our reduction also yields that for every d
    ≥ 2 and k ≥ 0, deciding if a pure, d-dimensional, simplicial complex is k-decomposable
    is NP-hard. For d ≥ 3, both problems remain NP-hard when restricted to contractible
    pure d-dimensional complexes.
acknowledgement: 'Partially supported by the project EMBEDS II (CZ: 7AMB17FR029, FR:
  38087RM) of Czech-French collaboration.'
alternative_title:
- Leibniz International Proceedings in Information, LIPIcs
author:
- first_name: Xavier
  full_name: Goaoc, Xavier
  last_name: Goaoc
- first_name: Pavel
  full_name: Paták, Pavel
  last_name: Paták
- first_name: Zuzana
  full_name: Patakova, Zuzana
  id: 48B57058-F248-11E8-B48F-1D18A9856A87
  last_name: Patakova
  orcid: 0000-0002-3975-1683
- first_name: Martin
  full_name: Tancer, Martin
  id: 38AC689C-F248-11E8-B48F-1D18A9856A87
  last_name: Tancer
  orcid: 0000-0002-1191-6714
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
citation:
  ama: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. Shellability is NP-complete.
    In: Vol 99. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2018:41:1-41:16.
    doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.41">10.4230/LIPIcs.SoCG.2018.41</a>'
  apa: 'Goaoc, X., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2018). Shellability
    is NP-complete (Vol. 99, p. 41:1-41:16). Presented at the SoCG: Symposium on Computational
    Geometry, Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
    <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.41">https://doi.org/10.4230/LIPIcs.SoCG.2018.41</a>'
  chicago: Goaoc, Xavier, Pavel Paták, Zuzana Patakova, Martin Tancer, and Uli Wagner.
    “Shellability Is NP-Complete,” 99:41:1-41:16. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.41">https://doi.org/10.4230/LIPIcs.SoCG.2018.41</a>.
  ieee: 'X. Goaoc, P. Paták, Z. Patakova, M. Tancer, and U. Wagner, “Shellability
    is NP-complete,” presented at the SoCG: Symposium on Computational Geometry, Budapest,
    Hungary, 2018, vol. 99, p. 41:1-41:16.'
  ista: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. 2018. Shellability is NP-complete.
    SoCG: Symposium on Computational Geometry, Leibniz International Proceedings in
    Information, LIPIcs, vol. 99, 41:1-41:16.'
  mla: Goaoc, Xavier, et al. <i>Shellability Is NP-Complete</i>. Vol. 99, Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2018, p. 41:1-41:16, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.41">10.4230/LIPIcs.SoCG.2018.41</a>.
  short: X. Goaoc, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2018, p. 41:1-41:16.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:04Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2025-06-04T07:49:02Z
day: '11'
ddc:
- '516'
- '000'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2018.41
file:
- access_level: open_access
  checksum: d12bdd60f04a57307867704b5f930afd
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:35:02Z
  date_updated: 2020-07-14T12:45:18Z
  file_id: '5725'
  file_name: 2018_LIPIcs_Goaoc.pdf
  file_size: 718414
  relation: main_file
file_date_updated: 2020-07-14T12:45:18Z
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 41:1 - 41:16
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7736'
quality_controlled: '1'
related_material:
  record:
  - id: '7108'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Shellability is NP-complete
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '185'
abstract:
- lang: eng
  text: We resolve in the affirmative conjectures of A. Skopenkov and Repovš (1998),
    and M. Skopenkov (2003) generalizing the classical Hanani-Tutte theorem to the
    setting of approximating maps of graphs on 2-dimensional surfaces by embeddings.
    Our proof of this result is constructive and almost immediately implies an efficient
    algorithm for testing whether a given piecewise linear map of a graph in a surface
    is approximable by an embedding. More precisely, an instance of this problem consists
    of (i) a graph G whose vertices are partitioned into clusters and whose inter-cluster
    edges are partitioned into bundles, and (ii) a region R of a 2-dimensional compact
    surface M given as the union of a set of pairwise disjoint discs corresponding
    to the clusters and a set of pairwise disjoint &quot;pipes&quot; corresponding
    to the bundles, connecting certain pairs of these discs. We are to decide whether
    G can be embedded inside M so that the vertices in every cluster are drawn in
    the corresponding disc, the edges in every bundle pass only through its corresponding
    pipe, and every edge crosses the boundary of each disc at most once.
alternative_title:
- Leibniz International Proceedings in Information, LIPIcs
article_number: '39'
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Jan
  full_name: Kynčl, Jan
  last_name: Kynčl
citation:
  ama: 'Fulek R, Kynčl J. Hanani-Tutte for approximating maps of graphs. In: Vol 99.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2018. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">10.4230/LIPIcs.SoCG.2018.39</a>'
  apa: 'Fulek, R., &#38; Kynčl, J. (2018). Hanani-Tutte for approximating maps of
    graphs (Vol. 99). Presented at the SoCG: Symposium on Computational Geometry,
    Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">https://doi.org/10.4230/LIPIcs.SoCG.2018.39</a>'
  chicago: Fulek, Radoslav, and Jan Kynčl. “Hanani-Tutte for Approximating Maps of
    Graphs,” Vol. 99. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018. <a
    href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">https://doi.org/10.4230/LIPIcs.SoCG.2018.39</a>.
  ieee: 'R. Fulek and J. Kynčl, “Hanani-Tutte for approximating maps of graphs,” presented
    at the SoCG: Symposium on Computational Geometry, Budapest, Hungary, 2018, vol.
    99.'
  ista: 'Fulek R, Kynčl J. 2018. Hanani-Tutte for approximating maps of graphs. SoCG:
    Symposium on Computational Geometry, Leibniz International Proceedings in Information,
    LIPIcs, vol. 99, 39.'
  mla: Fulek, Radoslav, and Jan Kynčl. <i>Hanani-Tutte for Approximating Maps of Graphs</i>.
    Vol. 99, 39, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">10.4230/LIPIcs.SoCG.2018.39</a>.
  short: R. Fulek, J. Kynčl, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:04Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2021-01-12T06:53:36Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2018.39
file:
- access_level: open_access
  checksum: f1b94f1a75b37c414a1f61d59fb2cd4c
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T12:33:52Z
  date_updated: 2020-07-14T12:45:19Z
  file_id: '5701'
  file_name: 2018_LIPIcs_Fulek.pdf
  file_size: 718857
  relation: main_file
file_date_updated: 2020-07-14T12:45:19Z
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 261FA626-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02281
  name: Eliminating intersections in drawings of graphs
publication_identifier:
  isbn:
  - 978-3-95977-066-8
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7735'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hanani-Tutte for approximating maps of graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '186'
abstract:
- lang: eng
  text: 'A drawing of a graph on a surface is independently even if every pair of
    nonadjacent edges in the drawing crosses an even number of times. The ℤ2-genus
    of a graph G is the minimum g such that G has an independently even drawing on
    the orientable surface of genus g. An unpublished result by Robertson and Seymour
    implies that for every t, every graph of sufficiently large genus contains as
    a minor a projective t × t grid or one of the following so-called t-Kuratowski
    graphs: K3, t, or t copies of K5 or K3,3 sharing at most 2 common vertices. We
    show that the ℤ2-genus of graphs in these families is unbounded in t; in fact,
    equal to their genus. Together, this implies that the genus of a graph is bounded
    from above by a function of its ℤ2-genus, solving a problem posed by Schaefer
    and Štefankovič, and giving an approximate version of the Hanani-Tutte theorem
    on orientable surfaces.'
alternative_title:
- LIPIcs
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Jan
  full_name: Kynčl, Jan
  last_name: Kynčl
citation:
  ama: 'Fulek R, Kynčl J. The ℤ2-Genus of Kuratowski minors. In: Vol 99. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik; 2018:40.1-40.14. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">10.4230/LIPIcs.SoCG.2018.40</a>'
  apa: 'Fulek, R., &#38; Kynčl, J. (2018). The ℤ2-Genus of Kuratowski minors (Vol.
    99, p. 40.1-40.14). Presented at the SoCG: Symposium on Computational Geometry,
    Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">https://doi.org/10.4230/LIPIcs.SoCG.2018.40</a>'
  chicago: Fulek, Radoslav, and Jan Kynčl. “The ℤ2-Genus of Kuratowski Minors,” 99:40.1-40.14.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">https://doi.org/10.4230/LIPIcs.SoCG.2018.40</a>.
  ieee: 'R. Fulek and J. Kynčl, “The ℤ2-Genus of Kuratowski minors,” presented at
    the SoCG: Symposium on Computational Geometry, Budapest, Hungary, 2018, vol. 99,
    p. 40.1-40.14.'
  ista: 'Fulek R, Kynčl J. 2018. The ℤ2-Genus of Kuratowski minors. SoCG: Symposium
    on Computational Geometry, LIPIcs, vol. 99, 40.1-40.14.'
  mla: Fulek, Radoslav, and Jan Kynčl. <i>The ℤ2-Genus of Kuratowski Minors</i>. Vol.
    99, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018, p. 40.1-40.14, doi:<a
    href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">10.4230/LIPIcs.SoCG.2018.40</a>.
  short: R. Fulek, J. Kynčl, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018, p. 40.1-40.14.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:05Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2025-04-14T13:52:37Z
day: '11'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2018.40
external_id:
  arxiv:
  - '1803.05085'
intvolume: '        99'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.05085
month: '06'
oa: 1
oa_version: Submitted Version
page: 40.1 - 40.14
project:
- _id: 261FA626-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02281
  name: Eliminating intersections in drawings of graphs
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7734'
quality_controlled: '1'
related_material:
  record:
  - id: '11593'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: The ℤ2-Genus of Kuratowski minors
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '13'
abstract:
- lang: eng
  text: We propose a new method for fabricating digital objects through reusable silicone
    molds. Molds are generated by casting liquid silicone into custom 3D printed containers
    called metamolds. Metamolds automatically define the cuts that are needed to extract
    the cast object from the silicone mold. The shape of metamolds is designed through
    a novel segmentation technique, which takes into account both geometric and topological
    constraints involved in the process of mold casting. Our technique is simple,
    does not require changing the shape or topology of the input objects, and only
    requires off-the- shelf materials and technologies. We successfully tested our
    method on a set of challenging examples with complex shapes and rich geometric
    detail. © 2018 Association for Computing Machinery.
article_number: '136'
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Alderighi, Thomas
  last_name: Alderighi
- first_name: Luigi
  full_name: Malomo, Luigi
  last_name: Malomo
- first_name: Daniela
  full_name: Giorgi, Daniela
  last_name: Giorgi
- first_name: Nico
  full_name: Pietroni, Nico
  last_name: Pietroni
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Paolo
  full_name: Cignoni, Paolo
  last_name: Cignoni
citation:
  ama: 'Alderighi T, Malomo L, Giorgi D, Pietroni N, Bickel B, Cignoni P. Metamolds:
    Computational design of silicone molds. <i>ACM Trans Graph</i>. 2018;37(4). doi:<a
    href="https://doi.org/10.1145/3197517.3201381">10.1145/3197517.3201381</a>'
  apa: 'Alderighi, T., Malomo, L., Giorgi, D., Pietroni, N., Bickel, B., &#38; Cignoni,
    P. (2018). Metamolds: Computational design of silicone molds. <i>ACM Trans. Graph.</i>
    ACM. <a href="https://doi.org/10.1145/3197517.3201381">https://doi.org/10.1145/3197517.3201381</a>'
  chicago: 'Alderighi, Thomas, Luigi Malomo, Daniela Giorgi, Nico Pietroni, Bernd
    Bickel, and Paolo Cignoni. “Metamolds: Computational Design of Silicone Molds.”
    <i>ACM Trans. Graph.</i> ACM, 2018. <a href="https://doi.org/10.1145/3197517.3201381">https://doi.org/10.1145/3197517.3201381</a>.'
  ieee: 'T. Alderighi, L. Malomo, D. Giorgi, N. Pietroni, B. Bickel, and P. Cignoni,
    “Metamolds: Computational design of silicone molds,” <i>ACM Trans. Graph.</i>,
    vol. 37, no. 4. ACM, 2018.'
  ista: 'Alderighi T, Malomo L, Giorgi D, Pietroni N, Bickel B, Cignoni P. 2018. Metamolds:
    Computational design of silicone molds. ACM Trans. Graph. 37(4), 136.'
  mla: 'Alderighi, Thomas, et al. “Metamolds: Computational Design of Silicone Molds.”
    <i>ACM Trans. Graph.</i>, vol. 37, no. 4, 136, ACM, 2018, doi:<a href="https://doi.org/10.1145/3197517.3201381">10.1145/3197517.3201381</a>.'
  short: T. Alderighi, L. Malomo, D. Giorgi, N. Pietroni, B. Bickel, P. Cignoni, ACM
    Trans. Graph. 37 (2018).
date_created: 2018-12-11T11:44:09Z
date_published: 2018-08-04T00:00:00Z
date_updated: 2025-04-14T07:28:57Z
day: '04'
ddc:
- '004'
department:
- _id: BeBi
doi: 10.1145/3197517.3201381
ec_funded: 1
external_id:
  isi:
  - '000448185000097'
file:
- access_level: open_access
  checksum: 61d46273dca4de626accef1d17a0aaad
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:18:52Z
  date_updated: 2020-07-14T12:44:43Z
  file_id: '5374'
  file_name: IST-2018-1038-v1+1_metamolds_authorversion.pdf
  file_size: 91939066
  relation: main_file
file_date_updated: 2020-07-14T12:44:43Z
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '4'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715767'
  name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
    Modeling'
publication: ACM Trans. Graph.
publication_status: published
publisher: ACM
publist_id: '8043'
pubrep_id: '1038'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/metamolds-molding-a-mold/
scopus_import: '1'
status: public
title: 'Metamolds: Computational design of silicone molds'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 37
year: '2018'
...
---
_id: '13055'
abstract:
- lang: eng
  text: "Dataset for manuscript 'Social network plasticity decreases disease transmission
    in a eusocial insect'\r\nCompared to previous versions: - raw image files added\r\n
    \                                                    - correction of URLs within
    README.txt file\r\n"
article_processing_charge: No
author:
- first_name: Nathalie
  full_name: Stroeymeyt, Nathalie
  last_name: Stroeymeyt
- first_name: Anna V
  full_name: Grasse, Anna V
  id: 406F989C-F248-11E8-B48F-1D18A9856A87
  last_name: Grasse
- first_name: Alessandro
  full_name: Crespi, Alessandro
  last_name: Crespi
- first_name: Danielle
  full_name: Mersch, Danielle
  last_name: Mersch
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Laurent
  full_name: Keller, Laurent
  last_name: Keller
citation:
  ama: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network
    plasticity decreases disease transmission in a eusocial insect. 2018. doi:<a href="https://doi.org/10.5281/ZENODO.1322669">10.5281/ZENODO.1322669</a>
  apa: Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., &#38; Keller,
    L. (2018). Social network plasticity decreases disease transmission in a eusocial
    insect. Zenodo. <a href="https://doi.org/10.5281/ZENODO.1322669">https://doi.org/10.5281/ZENODO.1322669</a>
  chicago: Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch,
    Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease
    Transmission in a Eusocial Insect.” Zenodo, 2018. <a href="https://doi.org/10.5281/ZENODO.1322669">https://doi.org/10.5281/ZENODO.1322669</a>.
  ieee: N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller,
    “Social network plasticity decreases disease transmission in a eusocial insect.”
    Zenodo, 2018.
  ista: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social
    network plasticity decreases disease transmission in a eusocial insect, Zenodo,
    <a href="https://doi.org/10.5281/ZENODO.1322669">10.5281/ZENODO.1322669</a>.
  mla: Stroeymeyt, Nathalie, et al. <i>Social Network Plasticity Decreases Disease
    Transmission in a Eusocial Insect</i>. Zenodo, 2018, doi:<a href="https://doi.org/10.5281/ZENODO.1322669">10.5281/ZENODO.1322669</a>.
  short: N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, (2018).
date_created: 2023-05-23T13:24:51Z
date_published: 2018-10-23T00:00:00Z
date_updated: 2025-04-15T08:20:52Z
day: '23'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.5281/ZENODO.1322669
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.1480665
month: '10'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
  record:
  - id: '7'
    relation: used_in_publication
    status: public
status: public
title: Social network plasticity decreases disease transmission in a eusocial insect
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '13059'
abstract:
- lang: eng
  text: "This dataset contains a GitHub repository containing all the data, analysis,
    Nextflow workflows and Jupyter notebooks to replicate the manuscript titled \"Fast
    and accurate large multiple sequence alignments with a root-to-leaf regressive
    method\".\r\nIt also contains the Multiple Sequence Alignments (MSAs) generated
    and well as the main figures and tables from the manuscript.\r\nThe repository
    is also available at GitHub (https://github.com/cbcrg/dpa-analysis) release `v1.2`.\r\nFor
    details on how to use the regressive alignment algorithm, see the T-Coffee software
    suite (https://github.com/cbcrg/tcoffee)."
article_processing_charge: No
author:
- first_name: Edgar
  full_name: Garriga, Edgar
  last_name: Garriga
- first_name: Paolo
  full_name: di Tommaso, Paolo
  last_name: di Tommaso
- first_name: Cedrik
  full_name: Magis, Cedrik
  last_name: Magis
- first_name: Ionas
  full_name: Erb, Ionas
  last_name: Erb
- first_name: Leila
  full_name: Mansouri, Leila
  last_name: Mansouri
- first_name: Athanasios
  full_name: Baltzis, Athanasios
  last_name: Baltzis
- first_name: Hafid
  full_name: Laayouni, Hafid
  last_name: Laayouni
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Evan
  full_name: Floden, Evan
  last_name: Floden
- first_name: Cedric
  full_name: Notredame, Cedric
  last_name: Notredame
citation:
  ama: Garriga E, di Tommaso P, Magis C, et al. Fast and accurate large multiple sequence
    alignments with a root-to-leaf regressive method. 2018. doi:<a href="https://doi.org/10.5281/ZENODO.2025846">10.5281/ZENODO.2025846</a>
  apa: Garriga, E., di Tommaso, P., Magis, C., Erb, I., Mansouri, L., Baltzis, A.,
    … Notredame, C. (2018). Fast and accurate large multiple sequence alignments with
    a root-to-leaf regressive method. Zenodo. <a href="https://doi.org/10.5281/ZENODO.2025846">https://doi.org/10.5281/ZENODO.2025846</a>
  chicago: Garriga, Edgar, Paolo di Tommaso, Cedrik Magis, Ionas Erb, Leila Mansouri,
    Athanasios Baltzis, Hafid Laayouni, Fyodor Kondrashov, Evan Floden, and Cedric
    Notredame. “Fast and Accurate Large Multiple Sequence Alignments with a Root-to-Leaf
    Regressive Method.” Zenodo, 2018. <a href="https://doi.org/10.5281/ZENODO.2025846">https://doi.org/10.5281/ZENODO.2025846</a>.
  ieee: E. Garriga <i>et al.</i>, “Fast and accurate large multiple sequence alignments
    with a root-to-leaf regressive method.” Zenodo, 2018.
  ista: Garriga E, di Tommaso P, Magis C, Erb I, Mansouri L, Baltzis A, Laayouni H,
    Kondrashov F, Floden E, Notredame C. 2018. Fast and accurate large multiple sequence
    alignments with a root-to-leaf regressive method, Zenodo, <a href="https://doi.org/10.5281/ZENODO.2025846">10.5281/ZENODO.2025846</a>.
  mla: Garriga, Edgar, et al. <i>Fast and Accurate Large Multiple Sequence Alignments
    with a Root-to-Leaf Regressive Method</i>. Zenodo, 2018, doi:<a href="https://doi.org/10.5281/ZENODO.2025846">10.5281/ZENODO.2025846</a>.
  short: E. Garriga, P. di Tommaso, C. Magis, I. Erb, L. Mansouri, A. Baltzis, H.
    Laayouni, F. Kondrashov, E. Floden, C. Notredame, (2018).
date_created: 2023-05-23T16:08:20Z
date_published: 2018-12-07T00:00:00Z
date_updated: 2025-07-10T11:54:19Z
day: '07'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.5281/ZENODO.2025846
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.3271452
month: '12'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
  record:
  - id: '7181'
    relation: used_in_publication
    status: public
status: public
title: Fast and accurate large multiple sequence alignments with a root-to-leaf regressive
  method
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '131'
abstract:
- lang: eng
  text: 'XY systems usually show chromosome-wide compensation of X-linked genes, while
    in many ZW systems, compensation is restricted to a minority of dosage-sensitive
    genes. Why such differences arose is still unclear. Here, we combine comparative
    genomics, transcriptomics and proteomics to obtain a complete overview of the
    evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare
    the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium)
    and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary
    strata. We use these to assess gene expression evolution following sex-linkage.
    The resulting patterns suggest a reduction in expression of Z-linked genes in
    females, combined with upregulation of the Z in both sexes, in line with the first
    step of Ohno’s classic model of dosage compensation evolution. Quantitative proteomics
    suggest that post-transcriptional mechanisms do not play a major role in balancing
    the expression of Z-linked genes. '
acknowledgement: We are grateful to Lu Dabing (Soochow University, Suzhou, China)
  for providing Schistosoma japonicum samples, to Ariana Macon (IST Austria) and Georgette
  Stovall (JLU Giessen) for technical assistance, to IT support at IST Austria for
  providing optimal environment to bioinformatic analyses, and to the Vicoso lab for
  comments on the manuscript.
article_number: e35684
article_processing_charge: No
article_type: original
author:
- first_name: Marion A
  full_name: Picard, Marion A
  id: 2C921A7A-F248-11E8-B48F-1D18A9856A87
  last_name: Picard
  orcid: 0000-0002-8101-2518
- first_name: Celine
  full_name: Cosseau, Celine
  last_name: Cosseau
- first_name: Sabrina
  full_name: Ferré, Sabrina
  last_name: Ferré
- first_name: Thomas
  full_name: Quack, Thomas
  last_name: Quack
- first_name: Christoph
  full_name: Grevelding, Christoph
  last_name: Grevelding
- first_name: Yohann
  full_name: Couté, Yohann
  last_name: Couté
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Picard MAL, Cosseau C, Ferré S, et al. Evolution of gene dosage on the Z-chromosome
    of schistosome parasites. <i>eLife</i>. 2018;7. doi:<a href="https://doi.org/10.7554/eLife.35684">10.7554/eLife.35684</a>
  apa: Picard, M. A. L., Cosseau, C., Ferré, S., Quack, T., Grevelding, C., Couté,
    Y., &#38; Vicoso, B. (2018). Evolution of gene dosage on the Z-chromosome of schistosome
    parasites. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.35684">https://doi.org/10.7554/eLife.35684</a>
  chicago: Picard, Marion A L, Celine Cosseau, Sabrina Ferré, Thomas Quack, Christoph
    Grevelding, Yohann Couté, and Beatriz Vicoso. “Evolution of Gene Dosage on the
    Z-Chromosome of Schistosome Parasites.” <i>ELife</i>. eLife Sciences Publications,
    2018. <a href="https://doi.org/10.7554/eLife.35684">https://doi.org/10.7554/eLife.35684</a>.
  ieee: M. A. L. Picard <i>et al.</i>, “Evolution of gene dosage on the Z-chromosome
    of schistosome parasites,” <i>eLife</i>, vol. 7. eLife Sciences Publications,
    2018.
  ista: Picard MAL, Cosseau C, Ferré S, Quack T, Grevelding C, Couté Y, Vicoso B.
    2018. Evolution of gene dosage on the Z-chromosome of schistosome parasites. eLife.
    7, e35684.
  mla: Picard, Marion A. L., et al. “Evolution of Gene Dosage on the Z-Chromosome
    of Schistosome Parasites.” <i>ELife</i>, vol. 7, e35684, eLife Sciences Publications,
    2018, doi:<a href="https://doi.org/10.7554/eLife.35684">10.7554/eLife.35684</a>.
  short: M.A.L. Picard, C. Cosseau, S. Ferré, T. Quack, C. Grevelding, Y. Couté, B.
    Vicoso, ELife 7 (2018).
date_created: 2018-12-11T11:44:47Z
date_published: 2018-08-13T00:00:00Z
date_updated: 2025-04-15T08:18:37Z
day: '13'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.7554/eLife.35684
external_id:
  isi:
  - '000441388200001'
file:
- access_level: open_access
  checksum: d6331d4385b1fffd6b47b45d5949d841
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T11:55:05Z
  date_updated: 2020-07-14T12:44:43Z
  file_id: '5695'
  file_name: 2018_eLife_Picard.pdf
  file_size: 3158125
  relation: main_file
file_date_updated: 2020-07-14T12:44:43Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28842-B22
  name: Sex chromosome evolution under male- and female- heterogamety
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7792'
quality_controlled: '1'
related_material:
  record:
  - id: '5586'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Evolution of gene dosage on the Z-chromosome of schistosome parasites
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...
---
_id: '132'
abstract:
- lang: eng
  text: Pancreas development involves a coordinated process in which an early phase
    of cell segregation is followed by a longer phase of lineage restriction, expansion,
    and tissue remodeling. By combining clonal tracing and whole-mount reconstruction
    with proliferation kinetics and single-cell transcriptional profiling, we define
    the functional basis of pancreas morphogenesis. We show that the large-scale organization
    of mouse pancreas can be traced to the activity of self-renewing precursors positioned
    at the termini of growing ducts, which act collectively to drive serial rounds
    of stochastic ductal bifurcation balanced by termination. During this phase of
    branching morphogenesis, multipotent precursors become progressively fate-restricted,
    giving rise to self-renewing acinar-committed precursors that are conveyed with
    growing ducts, as well as ductal progenitors that expand the trailing ducts and
    give rise to delaminating endocrine cells. These findings define quantitatively
    how the functional behavior and lineage progression of precursor pools determine
    the large-scale patterning of pancreatic sub-compartments.
acknowledgement: E.H. is funded by a Junior Research Fellowship from Trinity College,
  Cam-bridge, a Sir Henry Wellcome Fellowship from the Wellcome Trust, and theBettencourt-Schueller
  Young Researcher Prize for support.
article_processing_charge: No
article_type: original
author:
- first_name: Magdalena
  full_name: Sznurkowska, Magdalena
  last_name: Sznurkowska
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Roberta
  full_name: Azzarelli, Roberta
  last_name: Azzarelli
- first_name: Steffen
  full_name: Rulands, Steffen
  last_name: Rulands
- first_name: Sonia
  full_name: Nestorowa, Sonia
  last_name: Nestorowa
- first_name: Christopher
  full_name: Hindley, Christopher
  last_name: Hindley
- first_name: Jennifer
  full_name: Nichols, Jennifer
  last_name: Nichols
- first_name: Berthold
  full_name: Göttgens, Berthold
  last_name: Göttgens
- first_name: Meritxell
  full_name: Huch, Meritxell
  last_name: Huch
- first_name: Anna
  full_name: Philpott, Anna
  last_name: Philpott
- first_name: Benjamin
  full_name: Simons, Benjamin
  last_name: Simons
citation:
  ama: Sznurkowska M, Hannezo EB, Azzarelli R, et al. Defining lineage potential and
    fate behavior of precursors during pancreas development. <i>Developmental Cell</i>.
    2018;46(3):360-375. doi:<a href="https://doi.org/10.1016/j.devcel.2018.06.028">10.1016/j.devcel.2018.06.028</a>
  apa: Sznurkowska, M., Hannezo, E. B., Azzarelli, R., Rulands, S., Nestorowa, S.,
    Hindley, C., … Simons, B. (2018). Defining lineage potential and fate behavior
    of precursors during pancreas development. <i>Developmental Cell</i>. Cell Press.
    <a href="https://doi.org/10.1016/j.devcel.2018.06.028">https://doi.org/10.1016/j.devcel.2018.06.028</a>
  chicago: Sznurkowska, Magdalena, Edouard B Hannezo, Roberta Azzarelli, Steffen Rulands,
    Sonia Nestorowa, Christopher Hindley, Jennifer Nichols, et al. “Defining Lineage
    Potential and Fate Behavior of Precursors during Pancreas Development.” <i>Developmental
    Cell</i>. Cell Press, 2018. <a href="https://doi.org/10.1016/j.devcel.2018.06.028">https://doi.org/10.1016/j.devcel.2018.06.028</a>.
  ieee: M. Sznurkowska <i>et al.</i>, “Defining lineage potential and fate behavior
    of precursors during pancreas development,” <i>Developmental Cell</i>, vol. 46,
    no. 3. Cell Press, pp. 360–375, 2018.
  ista: Sznurkowska M, Hannezo EB, Azzarelli R, Rulands S, Nestorowa S, Hindley C,
    Nichols J, Göttgens B, Huch M, Philpott A, Simons B. 2018. Defining lineage potential
    and fate behavior of precursors during pancreas development. Developmental Cell.
    46(3), 360–375.
  mla: Sznurkowska, Magdalena, et al. “Defining Lineage Potential and Fate Behavior
    of Precursors during Pancreas Development.” <i>Developmental Cell</i>, vol. 46,
    no. 3, Cell Press, 2018, pp. 360–75, doi:<a href="https://doi.org/10.1016/j.devcel.2018.06.028">10.1016/j.devcel.2018.06.028</a>.
  short: M. Sznurkowska, E.B. Hannezo, R. Azzarelli, S. Rulands, S. Nestorowa, C.
    Hindley, J. Nichols, B. Göttgens, M. Huch, A. Philpott, B. Simons, Developmental
    Cell 46 (2018) 360–375.
date_created: 2018-12-11T11:44:48Z
date_published: 2018-08-06T00:00:00Z
date_updated: 2023-09-11T12:52:41Z
day: '06'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.devcel.2018.06.028
external_id:
  isi:
  - '000441327300012'
file:
- access_level: open_access
  checksum: 78d2062b9e3c3b90fe71545aeb6d2f65
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T10:49:49Z
  date_updated: 2020-07-14T12:44:43Z
  file_id: '5694'
  file_name: 2018_DevelopmentalCell_Sznurkowska.pdf
  file_size: 8948384
  relation: main_file
file_date_updated: 2020-07-14T12:44:43Z
has_accepted_license: '1'
intvolume: '        46'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 360 - 375
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '7791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Defining lineage potential and fate behavior of precursors during pancreas
  development
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 46
year: '2018'
...
---
_id: '198'
abstract:
- lang: eng
  text: We consider a class of students learning a language from a teacher. The situation
    can be interpreted as a group of child learners receiving input from the linguistic
    environment. The teacher provides sample sentences. The students try to learn
    the grammar from the teacher. In addition to just listening to the teacher, the
    students can also communicate with each other. The students hold hypotheses about
    the grammar and change them if they receive counter evidence. The process stops
    when all students have converged to the correct grammar. We study how the time
    to convergence depends on the structure of the classroom by introducing and evaluating
    various complexity measures. We find that structured communication between students,
    although potentially introducing confusion, can greatly reduce some of the complexity
    measures. Our theory can also be interpreted as applying to the scientific process,
    where nature is the teacher and the scientists are the students.
article_number: '20180073'
article_processing_charge: No
article_type: original
author:
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
citation:
  ama: Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. Language acquisition with
    communication between learners. <i>Journal of the Royal Society Interface</i>.
    2018;15(140). doi:<a href="https://doi.org/10.1098/rsif.2018.0073">10.1098/rsif.2018.0073</a>
  apa: Ibsen-Jensen, R., Tkadlec, J., Chatterjee, K., &#38; Nowak, M. (2018). Language
    acquisition with communication between learners. <i>Journal of the Royal Society
    Interface</i>. The Royal Society. <a href="https://doi.org/10.1098/rsif.2018.0073">https://doi.org/10.1098/rsif.2018.0073</a>
  chicago: Ibsen-Jensen, Rasmus, Josef Tkadlec, Krishnendu Chatterjee, and Martin
    Nowak. “Language Acquisition with Communication between Learners.” <i>Journal
    of the Royal Society Interface</i>. The Royal Society, 2018. <a href="https://doi.org/10.1098/rsif.2018.0073">https://doi.org/10.1098/rsif.2018.0073</a>.
  ieee: R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, and M. Nowak, “Language acquisition
    with communication between learners,” <i>Journal of the Royal Society Interface</i>,
    vol. 15, no. 140. The Royal Society, 2018.
  ista: Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. 2018. Language acquisition
    with communication between learners. Journal of the Royal Society Interface. 15(140),
    20180073.
  mla: Ibsen-Jensen, Rasmus, et al. “Language Acquisition with Communication between
    Learners.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 140, 20180073,
    The Royal Society, 2018, doi:<a href="https://doi.org/10.1098/rsif.2018.0073">10.1098/rsif.2018.0073</a>.
  short: R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, M. Nowak, Journal of the Royal
    Society Interface 15 (2018).
date_created: 2018-12-11T11:45:09Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2025-04-15T07:26:26Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1098/rsif.2018.0073
ec_funded: 1
external_id:
  isi:
  - '000428576200023'
  pmid:
  - '29593089'
file:
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  checksum: 444e1a9d98eb0e780671be82b13025f3
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-12T07:54:37Z
  date_updated: 2020-07-14T12:45:22Z
  file_id: '5955'
  file_name: 2018_RS_IbsenJensen.pdf
  file_size: 219837
  relation: main_file
file_date_updated: 2020-07-14T12:45:22Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '140'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
pmid: 1
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication: Journal of the Royal Society Interface
publication_identifier:
  eissn:
  - 1742-5662
publication_status: published
publisher: The Royal Society
publist_id: '7715'
quality_controlled: '1'
related_material:
  link:
  - relation: supplementary_material
    url: https://dx.doi.org/10.6084/m9.figshare.c.4028971
  record:
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scopus_import: '1'
status: public
title: Language acquisition with communication between learners
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2018'
...
---
_id: '199'
abstract:
- lang: eng
  text: Sex-biased genes are central to the study of sexual selection, sexual antagonism,
    and sex chromosome evolution. We describe a comprehensive de novo assembled transcriptome
    in the common frog Rana temporaria based on five developmental stages and three
    adult tissues from both sexes, obtained from a population with karyotypically
    homomorphic but genetically differentiated sex chromosomes. This allows the study
    of sex-biased gene expression throughout development, and its effect on the rate
    of gene evolution while accounting for pleiotropic expression, which is known
    to negatively correlate with the evolutionary rate. Overall, sex-biased genes
    had little overlap among developmental stages and adult tissues. Late developmental
    stages and gonad tissues had the highest numbers of stage-or tissue-specific genes.
    We find that pleiotropic gene expression is a better predictor than sex bias for
    the evolutionary rate of genes, though it often interacts with sex bias. Although
    genetically differentiated, the sex chromosomes were not enriched in sex-biased
    genes, possibly due to a very recent arrest of XY recombination. These results
    extend our understanding of the developmental dynamics, tissue specificity, and
    genomic localization of sex-biased genes.
article_number: '294'
article_processing_charge: No
author:
- first_name: Wen
  full_name: Ma, Wen
  last_name: Ma
- first_name: Paris
  full_name: Veltsos, Paris
  last_name: Veltsos
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Nicolas
  full_name: Rodrigues, Nicolas
  last_name: Rodrigues
- first_name: Roberto
  full_name: Sermier, Roberto
  last_name: Sermier
- first_name: Daniel
  full_name: Jeffries, Daniel
  last_name: Jeffries
- first_name: Nicolas
  full_name: Perrin, Nicolas
  last_name: Perrin
citation:
  ama: Ma W, Veltsos P, Toups MA, et al. Tissue specificity and dynamics of sex biased
    gene expression in a common frog population with differentiated, yet homomorphic,
    sex chromosomes. <i>Genes</i>. 2018;9(6). doi:<a href="https://doi.org/10.3390/genes9060294">10.3390/genes9060294</a>
  apa: Ma, W., Veltsos, P., Toups, M. A., Rodrigues, N., Sermier, R., Jeffries, D.,
    &#38; Perrin, N. (2018). Tissue specificity and dynamics of sex biased gene expression
    in a common frog population with differentiated, yet homomorphic, sex chromosomes.
    <i>Genes</i>. MDPI. <a href="https://doi.org/10.3390/genes9060294">https://doi.org/10.3390/genes9060294</a>
  chicago: Ma, Wen, Paris Veltsos, Melissa A Toups, Nicolas Rodrigues, Roberto Sermier,
    Daniel Jeffries, and Nicolas Perrin. “Tissue Specificity and Dynamics of Sex Biased
    Gene Expression in a Common Frog Population with Differentiated, yet Homomorphic,
    Sex Chromosomes.” <i>Genes</i>. MDPI, 2018. <a href="https://doi.org/10.3390/genes9060294">https://doi.org/10.3390/genes9060294</a>.
  ieee: W. Ma <i>et al.</i>, “Tissue specificity and dynamics of sex biased gene expression
    in a common frog population with differentiated, yet homomorphic, sex chromosomes,”
    <i>Genes</i>, vol. 9, no. 6. MDPI, 2018.
  ista: Ma W, Veltsos P, Toups MA, Rodrigues N, Sermier R, Jeffries D, Perrin N. 2018.
    Tissue specificity and dynamics of sex biased gene expression in a common frog
    population with differentiated, yet homomorphic, sex chromosomes. Genes. 9(6),
    294.
  mla: Ma, Wen, et al. “Tissue Specificity and Dynamics of Sex Biased Gene Expression
    in a Common Frog Population with Differentiated, yet Homomorphic, Sex Chromosomes.”
    <i>Genes</i>, vol. 9, no. 6, 294, MDPI, 2018, doi:<a href="https://doi.org/10.3390/genes9060294">10.3390/genes9060294</a>.
  short: W. Ma, P. Veltsos, M.A. Toups, N. Rodrigues, R. Sermier, D. Jeffries, N.
    Perrin, Genes 9 (2018).
date_created: 2018-12-11T11:45:09Z
date_published: 2018-06-12T00:00:00Z
date_updated: 2024-12-11T13:13:35Z
day: '12'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.3390/genes9060294
external_id:
  isi:
  - '000436494200026'
file:
- access_level: open_access
  checksum: 423069beb1cd3cdd25bf3f464b38f1d7
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-01T07:52:28Z
  date_updated: 2020-07-14T12:45:22Z
  file_id: '5905'
  file_name: 2018_Genes_Ma.pdf
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file_date_updated: 2020-07-14T12:45:22Z
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Genes
publication_status: published
publisher: MDPI
publist_id: '7714'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tissue specificity and dynamics of sex biased gene expression in a common frog
  population with differentiated, yet homomorphic, sex chromosomes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2018'
...
---
_id: '20'
abstract:
- lang: eng
  text: 'Background: Norepinephrine (NE) signaling has a key role in white adipose
    tissue (WAT) functions, including lipolysis, free fatty acid liberation and, under
    certain conditions, conversion of white into brite (brown-in-white) adipocytes.
    However, acute effects of NE stimulation have not been described at the transcriptional
    network level. Results: We used RNA-seq to uncover a broad transcriptional response.
    The inference of protein-protein and protein-DNA interaction networks allowed
    us to identify a set of immediate-early genes (IEGs) with high betweenness, validating
    our approach and suggesting a hierarchical control of transcriptional regulation.
    In addition, we identified a transcriptional regulatory network with IEGs as master
    regulators, including HSF1 and NFIL3 as novel NE-induced IEG candidates. Moreover,
    a functional enrichment analysis and gene clustering into functional modules suggest
    a crosstalk between metabolic, signaling, and immune responses. Conclusions: Altogether,
    our network biology approach explores for the first time the immediate-early systems
    level response of human adipocytes to acute sympathetic activation, thereby providing
    a first network basis of early cell fate programs and crosstalks between metabolic
    and transcriptional networks required for proper WAT function.'
acknowledgement: This work was funded by the German Centre for Diabetes Research (DZD)
  and the Austrian Science Fund (FWF, P25729-B19).
article_processing_charge: No
article_type: original
author:
- first_name: Juan
  full_name: Higareda Almaraz, Juan
  last_name: Higareda Almaraz
- first_name: Michael
  full_name: Karbiener, Michael
  last_name: Karbiener
- first_name: Maude
  full_name: Giroud, Maude
  last_name: Giroud
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Teresa
  full_name: Gerhalter, Teresa
  last_name: Gerhalter
- first_name: Stephan
  full_name: Herzig, Stephan
  last_name: Herzig
- first_name: Marcel
  full_name: Scheideler, Marcel
  last_name: Scheideler
citation:
  ama: Higareda Almaraz J, Karbiener M, Giroud M, et al. Norepinephrine triggers an
    immediate-early regulatory network response in primary human white adipocytes.
    <i>BMC Genomics</i>. 2018;19(1). doi:<a href="https://doi.org/10.1186/s12864-018-5173-0">10.1186/s12864-018-5173-0</a>
  apa: Higareda Almaraz, J., Karbiener, M., Giroud, M., Pauler, F., Gerhalter, T.,
    Herzig, S., &#38; Scheideler, M. (2018). Norepinephrine triggers an immediate-early
    regulatory network response in primary human white adipocytes. <i>BMC Genomics</i>.
    BioMed Central. <a href="https://doi.org/10.1186/s12864-018-5173-0">https://doi.org/10.1186/s12864-018-5173-0</a>
  chicago: Higareda Almaraz, Juan, Michael Karbiener, Maude Giroud, Florian Pauler,
    Teresa Gerhalter, Stephan Herzig, and Marcel Scheideler. “Norepinephrine Triggers
    an Immediate-Early Regulatory Network Response in Primary Human White Adipocytes.”
    <i>BMC Genomics</i>. BioMed Central, 2018. <a href="https://doi.org/10.1186/s12864-018-5173-0">https://doi.org/10.1186/s12864-018-5173-0</a>.
  ieee: J. Higareda Almaraz <i>et al.</i>, “Norepinephrine triggers an immediate-early
    regulatory network response in primary human white adipocytes,” <i>BMC Genomics</i>,
    vol. 19, no. 1. BioMed Central, 2018.
  ista: Higareda Almaraz J, Karbiener M, Giroud M, Pauler F, Gerhalter T, Herzig S,
    Scheideler M. 2018. Norepinephrine triggers an immediate-early regulatory network
    response in primary human white adipocytes. BMC Genomics. 19(1).
  mla: Higareda Almaraz, Juan, et al. “Norepinephrine Triggers an Immediate-Early
    Regulatory Network Response in Primary Human White Adipocytes.” <i>BMC Genomics</i>,
    vol. 19, no. 1, BioMed Central, 2018, doi:<a href="https://doi.org/10.1186/s12864-018-5173-0">10.1186/s12864-018-5173-0</a>.
  short: J. Higareda Almaraz, M. Karbiener, M. Giroud, F. Pauler, T. Gerhalter, S.
    Herzig, M. Scheideler, BMC Genomics 19 (2018).
date_created: 2018-12-11T11:44:12Z
date_published: 2018-11-03T00:00:00Z
date_updated: 2023-09-13T09:10:47Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s12864-018-5173-0
external_id:
  isi:
  - '000450976700002'
file:
- access_level: open_access
  checksum: a56516e734dab589dc7f3e1915973b4d
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T14:52:57Z
  date_updated: 2020-07-14T12:45:23Z
  file_id: '5712'
  file_name: 2018_BMCGenomics_Higareda.pdf
  file_size: 4629784
  relation: main_file
file_date_updated: 2020-07-14T12:45:23Z
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: BMC Genomics
publication_identifier:
  issn:
  - 1471-2164
publication_status: published
publisher: BioMed Central
publist_id: '8035'
quality_controlled: '1'
related_material:
  record:
  - id: '9807'
    relation: research_data
    status: public
  - id: '9808'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Norepinephrine triggers an immediate-early regulatory network response in primary
  human white adipocytes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
_id: '188'
abstract:
- lang: eng
  text: Smallest enclosing spheres of finite point sets are central to methods in
    topological data analysis. Focusing on Bregman divergences to measure dissimilarity,
    we prove bounds on the location of the center of a smallest enclosing sphere.
    These bounds depend on the range of radii for which Bregman balls are convex.
acknowledgement: This research is partially supported by the Office of Naval Research,
  through grant no. N62909-18-1-2038, and the DFG Collaborative Research Center TRR
  109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of
  the Austrian Science Fund
alternative_title:
- Leibniz International Proceedings in Information, LIPIcs
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Ziga
  full_name: Virk, Ziga
  last_name: Virk
- first_name: Hubert
  full_name: Wagner, Hubert
  id: 379CA8B8-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
citation:
  ama: 'Edelsbrunner H, Virk Z, Wagner H. Smallest enclosing spheres and Chernoff
    points in Bregman geometry. In: Vol 99. Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik; 2018:35:1-35:13. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">10.4230/LIPIcs.SoCG.2018.35</a>'
  apa: 'Edelsbrunner, H., Virk, Z., &#38; Wagner, H. (2018). Smallest enclosing spheres
    and Chernoff points in Bregman geometry (Vol. 99, p. 35:1-35:13). Presented at
    the SoCG: Symposium on Computational Geometry, Budapest, Hungary: Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">https://doi.org/10.4230/LIPIcs.SoCG.2018.35</a>'
  chicago: Edelsbrunner, Herbert, Ziga Virk, and Hubert Wagner. “Smallest Enclosing
    Spheres and Chernoff Points in Bregman Geometry,” 99:35:1-35:13. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">https://doi.org/10.4230/LIPIcs.SoCG.2018.35</a>.
  ieee: 'H. Edelsbrunner, Z. Virk, and H. Wagner, “Smallest enclosing spheres and
    Chernoff points in Bregman geometry,” presented at the SoCG: Symposium on Computational
    Geometry, Budapest, Hungary, 2018, vol. 99, p. 35:1-35:13.'
  ista: 'Edelsbrunner H, Virk Z, Wagner H. 2018. Smallest enclosing spheres and Chernoff
    points in Bregman geometry. SoCG: Symposium on Computational Geometry, Leibniz
    International Proceedings in Information, LIPIcs, vol. 99, 35:1-35:13.'
  mla: Edelsbrunner, Herbert, et al. <i>Smallest Enclosing Spheres and Chernoff Points
    in Bregman Geometry</i>. Vol. 99, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018, p. 35:1-35:13, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">10.4230/LIPIcs.SoCG.2018.35</a>.
  short: H. Edelsbrunner, Z. Virk, H. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2018, p. 35:1-35:13.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:05Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2021-01-12T06:53:48Z
day: '11'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.4230/LIPIcs.SoCG.2018.35
file:
- access_level: open_access
  checksum: 7509403803b3ac1aee94bbc2ad293d21
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:31:31Z
  date_updated: 2020-07-14T12:45:20Z
  file_id: '5724'
  file_name: 2018_LIPIcs_Edelsbrunner.pdf
  file_size: 489080
  relation: main_file
file_date_updated: 2020-07-14T12:45:20Z
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 35:1 - 35:13
project:
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I02979-N35
  name: Persistence and stability of geometric complexes
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7733'
quality_controlled: '1'
scopus_import: 1
status: public
title: Smallest enclosing spheres and Chernoff points in Bregman geometry
tmp:
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
