---
_id: '9452'
abstract:
- lang: eng
text: Eukaryotic cytosine methylation represses transcription but also occurs in
the bodies of active genes, and the extent of methylation biology conservation
is unclear. We quantified DNA methylation in 17 eukaryotic genomes and found that
gene body methylation is conserved between plants and animals, whereas selective
methylation of transposons is not. We show that methylation of plant transposons
in the CHG context extends to green algae and that exclusion of histone H2A.Z
from methylated DNA is conserved between plants and animals, and we present evidence
for RNA-directed DNA methylation of fungal genes. Our data demonstrate that extant
DNA methylation systems are mosaics of conserved and derived features, and indicate
that gene body methylation is an ancient property of eukaryotic genomes.
article_processing_charge: No
article_type: original
author:
- first_name: 'Assaf '
full_name: 'Zemach, Assaf '
last_name: Zemach
- first_name: Ivy E.
full_name: McDaniel, Ivy E.
last_name: McDaniel
- first_name: Pedro
full_name: Silva, Pedro
last_name: Silva
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis
of eukaryotic DNA methylation. Science. 2010;328(5980):916-919. doi:10.1126/science.1186366
apa: Zemach, A., McDaniel, I. E., Silva, P., & Zilberman, D. (2010). Genome-wide
evolutionary analysis of eukaryotic DNA methylation. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.1186366
chicago: Zemach, Assaf , Ivy E. McDaniel, Pedro Silva, and Daniel Zilberman. “Genome-Wide
Evolutionary Analysis of Eukaryotic DNA Methylation.” Science. American
Association for the Advancement of Science, 2010. https://doi.org/10.1126/science.1186366.
ieee: A. Zemach, I. E. McDaniel, P. Silva, and D. Zilberman, “Genome-wide evolutionary
analysis of eukaryotic DNA methylation,” Science, vol. 328, no. 5980. American
Association for the Advancement of Science, pp. 916–919, 2010.
ista: Zemach A, McDaniel IE, Silva P, Zilberman D. 2010. Genome-wide evolutionary
analysis of eukaryotic DNA methylation. Science. 328(5980), 916–919.
mla: Zemach, Assaf, et al. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA
Methylation.” Science, vol. 328, no. 5980, American Association for the
Advancement of Science, 2010, pp. 916–19, doi:10.1126/science.1186366.
short: A. Zemach, I.E. McDaniel, P. Silva, D. Zilberman, Science 328 (2010) 916–919.
date_created: 2021-06-04T08:26:08Z
date_published: 2010-05-14T00:00:00Z
date_updated: 2021-12-14T08:35:37Z
day: '14'
department:
- _id: DaZi
doi: 10.1126/science.1186366
extern: '1'
external_id:
pmid:
- '20395474 '
intvolume: ' 328'
issue: '5980'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '05'
oa_version: None
page: 916-919
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genome-wide evolutionary analysis of eukaryotic DNA methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 328
year: '2010'
...
---
_id: '9485'
abstract:
- lang: eng
text: 'Cytosine methylation silences transposable elements in plants, vertebrates,
and fungi but also regulates gene expression. Plant methylation is catalyzed by
three families of enzymes, each with a preferred sequence context: CG, CHG (H
= A, C, or T), and CHH, with CHH methylation targeted by the RNAi pathway. Arabidopsis
thaliana endosperm, a placenta-like tissue that nourishes the embryo, is globally
hypomethylated in the CG context while retaining high non-CG methylation. Global
methylation dynamics in seeds of cereal crops that provide the bulk of human nutrition
remain unknown. Here, we show that rice endosperm DNA is hypomethylated in all
sequence contexts. Non-CG methylation is reduced evenly across the genome, whereas
CG hypomethylation is localized. CHH methylation of small transposable elements
is increased in embryos, suggesting that endosperm demethylation enhances transposon
silencing. Genes preferentially expressed in endosperm, including those coding
for major storage proteins and starch synthesizing enzymes, are frequently hypomethylated
in endosperm, indicating that DNA methylation is a crucial regulator of rice endosperm
biogenesis. Our data show that genome-wide reshaping of seed DNA methylation is
conserved among angiosperms and has a profound effect on gene expression in cereal
crops.'
article_processing_charge: No
article_type: original
author:
- first_name: Assaf
full_name: Zemach, Assaf
last_name: Zemach
- first_name: M. Yvonne
full_name: Kim, M. Yvonne
last_name: Kim
- first_name: Pedro
full_name: Silva, Pedro
last_name: Silva
- first_name: Jessica A.
full_name: Rodrigues, Jessica A.
last_name: Rodrigues
- first_name: Bradley
full_name: Dotson, Bradley
last_name: Dotson
- first_name: Matthew D.
full_name: Brooks, Matthew D.
last_name: Brooks
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Zemach A, Kim MY, Silva P, et al. Local DNA hypomethylation activates genes
in rice endosperm. Proceedings of the National Academy of Sciences. 2010;107(43):18729-18734.
doi:10.1073/pnas.1009695107
apa: Zemach, A., Kim, M. Y., Silva, P., Rodrigues, J. A., Dotson, B., Brooks, M.
D., & Zilberman, D. (2010). Local DNA hypomethylation activates genes in rice
endosperm. Proceedings of the National Academy of Sciences. National Academy
of Sciences. https://doi.org/10.1073/pnas.1009695107
chicago: Zemach, Assaf, M. Yvonne Kim, Pedro Silva, Jessica A. Rodrigues, Bradley
Dotson, Matthew D. Brooks, and Daniel Zilberman. “Local DNA Hypomethylation Activates
Genes in Rice Endosperm.” Proceedings of the National Academy of Sciences.
National Academy of Sciences, 2010. https://doi.org/10.1073/pnas.1009695107.
ieee: A. Zemach et al., “Local DNA hypomethylation activates genes in rice
endosperm,” Proceedings of the National Academy of Sciences, vol. 107,
no. 43. National Academy of Sciences, pp. 18729–18734, 2010.
ista: Zemach A, Kim MY, Silva P, Rodrigues JA, Dotson B, Brooks MD, Zilberman D.
2010. Local DNA hypomethylation activates genes in rice endosperm. Proceedings
of the National Academy of Sciences. 107(43), 18729–18734.
mla: Zemach, Assaf, et al. “Local DNA Hypomethylation Activates Genes in Rice Endosperm.”
Proceedings of the National Academy of Sciences, vol. 107, no. 43, National
Academy of Sciences, 2010, pp. 18729–34, doi:10.1073/pnas.1009695107.
short: A. Zemach, M.Y. Kim, P. Silva, J.A. Rodrigues, B. Dotson, M.D. Brooks, D.
Zilberman, Proceedings of the National Academy of Sciences 107 (2010) 18729–18734.
date_created: 2021-06-07T09:31:01Z
date_published: 2010-10-26T00:00:00Z
date_updated: 2021-12-14T08:40:02Z
day: '26'
department:
- _id: DaZi
doi: 10.1073/pnas.1009695107
extern: '1'
external_id:
pmid:
- '20937895'
intvolume: ' 107'
issue: '43'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1073/pnas.1009695107
month: '10'
oa: 1
oa_version: Published Version
page: 18729-18734
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Local DNA hypomethylation activates genes in rice endosperm
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 107
year: '2010'
...
---
_id: '9489'
abstract:
- lang: eng
text: Cytosine methylation is an ancient process with conserved enzymology but diverse
biological functions that include defense against transposable elements and regulation
of gene expression. Here we will discuss the evolution and biological significance
of eukaryotic DNA methylation, the likely drivers of that evolution, and major
remaining mysteries.
article_processing_charge: No
article_type: review
author:
- first_name: Assaf
full_name: Zemach, Assaf
last_name: Zemach
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Zemach A, Zilberman D. Evolution of eukaryotic DNA methylation and the pursuit
of safer sex. Current Biology. 2010;20(17):R780-R785. doi:10.1016/j.cub.2010.07.007
apa: Zemach, A., & Zilberman, D. (2010). Evolution of eukaryotic DNA methylation
and the pursuit of safer sex. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2010.07.007
chicago: Zemach, Assaf, and Daniel Zilberman. “Evolution of Eukaryotic DNA Methylation
and the Pursuit of Safer Sex.” Current Biology. Elsevier, 2010. https://doi.org/10.1016/j.cub.2010.07.007.
ieee: A. Zemach and D. Zilberman, “Evolution of eukaryotic DNA methylation and the
pursuit of safer sex,” Current Biology, vol. 20, no. 17. Elsevier, pp.
R780–R785, 2010.
ista: Zemach A, Zilberman D. 2010. Evolution of eukaryotic DNA methylation and the
pursuit of safer sex. Current Biology. 20(17), R780–R785.
mla: Zemach, Assaf, and Daniel Zilberman. “Evolution of Eukaryotic DNA Methylation
and the Pursuit of Safer Sex.” Current Biology, vol. 20, no. 17, Elsevier,
2010, pp. R780–85, doi:10.1016/j.cub.2010.07.007.
short: A. Zemach, D. Zilberman, Current Biology 20 (2010) R780–R785.
date_created: 2021-06-07T09:45:27Z
date_published: 2010-09-14T00:00:00Z
date_updated: 2021-12-14T08:52:34Z
day: '14'
department:
- _id: DaZi
doi: 10.1016/j.cub.2010.07.007
extern: '1'
external_id:
pmid:
- '20833323'
intvolume: ' 20'
issue: '17'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cub.2010.07.007
month: '09'
oa: 1
oa_version: Published Version
page: R780-R785
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolution of eukaryotic DNA methylation and the pursuit of safer sex
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 20
year: '2010'
...
---
_id: '9764'
article_processing_charge: No
author:
- first_name: Ulises
full_name: Rosas, Ulises
last_name: Rosas
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Lucy
full_name: Copsey, Lucy
last_name: Copsey
- first_name: Pierre
full_name: Barbier De Reuille, Pierre
last_name: Barbier De Reuille
- first_name: Enrico
full_name: Coen, Enrico
last_name: Coen
citation:
ama: Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. Heterosis and the
drift load. 2010. doi:10.1371/journal.pbio.1000429.s003
apa: Rosas, U., Barton, N. H., Copsey, L., Barbier De Reuille, P., & Coen, E.
(2010). Heterosis and the drift load. Public Library of Science. https://doi.org/10.1371/journal.pbio.1000429.s003
chicago: Rosas, Ulises, Nicholas H Barton, Lucy Copsey, Pierre Barbier De Reuille,
and Enrico Coen. “Heterosis and the Drift Load.” Public Library of Science, 2010.
https://doi.org/10.1371/journal.pbio.1000429.s003.
ieee: U. Rosas, N. H. Barton, L. Copsey, P. Barbier De Reuille, and E. Coen, “Heterosis
and the drift load.” Public Library of Science, 2010.
ista: Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. 2010. Heterosis
and the drift load, Public Library of Science, 10.1371/journal.pbio.1000429.s003.
mla: Rosas, Ulises, et al. Heterosis and the Drift Load. Public Library of
Science, 2010, doi:10.1371/journal.pbio.1000429.s003.
short: U. Rosas, N.H. Barton, L. Copsey, P. Barbier De Reuille, E. Coen, (2010).
date_created: 2021-08-02T09:45:39Z
date_published: 2010-07-20T00:00:00Z
date_updated: 2025-09-30T09:42:52Z
day: '20'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.1000429.s003
month: '07'
oa_version: Published Version
publisher: Public Library of Science
related_material:
record:
- id: '3779'
relation: used_in_publication
status: public
status: public
title: Heterosis and the drift load
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2010'
...
---
_id: '4542'
abstract:
- lang: eng
text: "Weighted automata are finite automata with numerical weights on transitions.
Nondeterministic weighted automata define quantitative languages L that assign
to each word w a real number L(w) computed as the maximal value of all runs over
w, and the value of a run r is a function of the sequence of weights that appear
along r. There are several natural functions to consider such as Sup, LimSup,
LimInf, limit average, and discounted sum of transition weights.\r\nWe introduce
alternating weighted automata in which the transitions of the runs are chosen
by two players in a turn-based fashion. Each word is assigned the maximal value
of a run that the first player can enforce regardless of the choices made by the
second player. We survey the results about closure properties, expressiveness,
and decision problems for nondeterministic weighted automata, and we extend these
results to alternating weighted automata.\r\nFor quantitative languages L 1 and
L 2, we consider the pointwise operations max(L 1,L 2), min(L 1,L 2), 1 − L 1,
and the sum L 1 + L 2. We establish the closure properties of all classes of alternating
weighted automata with respect to these four operations.\r\nWe next compare the
expressive power of the various classes of alternating and nondeterministic weighted
automata over infinite words. In particular, for limit average and discounted
sum, we show that alternation brings more expressive power than nondeterminism.\r\nFinally,
we present decidability results and open questions for the quantitative extension
of the classical decision problems in automata theory: emptiness, universality,
language inclusion, and language equivalence."
acknowledgement: This research was supported in part by the Swiss National Science
Foundation under the Indo-Swiss Joint Research Programme, by the European Network
of Excellence on Embedded Systems Design (ArtistDesign), by the European Combest,
Quasimodo, and Gasics projects, by the PAI program Moves funded by the Belgian Federal
Government, and by the CFV (Federated Center in Verification) funded by the F.R.S.-FNRS.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Chatterjee K, Doyen L, Henzinger TA. Alternating weighted automata. In: Vol
5699. Springer; 2009:3-13. doi:10.1007/978-3-642-03409-1_2'
apa: 'Chatterjee, K., Doyen, L., & Henzinger, T. A. (2009). Alternating weighted
automata (Vol. 5699, pp. 3–13). Presented at the FCT: Fundamentals of Computation
Theory, Wroclaw, Poland: Springer. https://doi.org/10.1007/978-3-642-03409-1_2'
chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “Alternating
Weighted Automata,” 5699:3–13. Springer, 2009. https://doi.org/10.1007/978-3-642-03409-1_2.
ieee: 'K. Chatterjee, L. Doyen, and T. A. Henzinger, “Alternating weighted automata,”
presented at the FCT: Fundamentals of Computation Theory, Wroclaw, Poland, 2009,
vol. 5699, pp. 3–13.'
ista: 'Chatterjee K, Doyen L, Henzinger TA. 2009. Alternating weighted automata.
FCT: Fundamentals of Computation Theory, LNCS, vol. 5699, 3–13.'
mla: Chatterjee, Krishnendu, et al. Alternating Weighted Automata. Vol. 5699,
Springer, 2009, pp. 3–13, doi:10.1007/978-3-642-03409-1_2.
short: K. Chatterjee, L. Doyen, T.A. Henzinger, in:, Springer, 2009, pp. 3–13.
conference:
end_date: 2009-09-04
location: Wroclaw, Poland
name: 'FCT: Fundamentals of Computation Theory'
start_date: 2009-09-02
corr_author: '1'
date_created: 2018-12-11T12:09:23Z
date_published: 2009-09-10T00:00:00Z
date_updated: 2024-10-09T20:53:55Z
day: '10'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.1007/978-3-642-03409-1_2
ec_funded: 1
file:
- access_level: open_access
checksum: e8f53abb63579de3f2bff58b2a1188e2
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:09Z
date_updated: 2020-07-14T12:46:31Z
file_id: '5126'
file_name: IST-2012-39-v1+1_Alternating_Weighted_Automata.pdf
file_size: 164428
relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
has_accepted_license: '1'
intvolume: ' 5699'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 3 - 13
project:
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '214373'
name: Design for Embedded Systems
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '180'
pubrep_id: '39'
quality_controlled: '1'
scopus_import: 1
status: public
title: Alternating weighted automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5699
year: '2009'
...
---
_id: '4543'
abstract:
- lang: eng
text: The synthesis of a reactive system with respect to all omega-regular specification
requires the solution of a graph game. Such games have been extended in two natural
ways. First, a game graph can be equipped with probabilistic choices between alternative
transitions, thus allowing the, modeling of uncertain behaviour. These are called
stochastic games. Second, a liveness specification can he strengthened to require
satisfaction within all unknown but bounded amount of time. These are called finitary
objectives. We study. for the first time, the, combination of Stochastic games
and finitary objectives. We characterize the requirements on optimal strategies
and provide algorithms for Computing the maximal achievable probability of winning
stochastic games with finitary parity or Street, objectives. Most notably the
set of state's from which a player can win with probability . for a finitary parity
objective can he computed in polynomial time even though no polynomial-time algorithm
is known in the nonfinitary case.
acknowledgement: This research was supported in part by the Swiss National Science
Foundation under the Indo-Swiss Joint Research Programme, by the European Network
of Excellence on Embedded Systems Design (ArtistDesign), and by the European project
Combest.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Florian
full_name: Horn, Florian
id: 37327ACE-F248-11E8-B48F-1D18A9856A87
last_name: Horn
citation:
ama: 'Chatterjee K, Henzinger TA, Horn F. Stochastic games with finitary objectives.
In: Vol 5734. Springer; 2009:34-54. doi:10.1007/978-3-642-03816-7_4'
apa: 'Chatterjee, K., Henzinger, T. A., & Horn, F. (2009). Stochastic games
with finitary objectives (Vol. 5734, pp. 34–54). Presented at the MFCS: Mathematical
Foundations of Computer Science, High Tatras, Slovakia: Springer. https://doi.org/10.1007/978-3-642-03816-7_4'
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Florian Horn. “Stochastic
Games with Finitary Objectives,” 5734:34–54. Springer, 2009. https://doi.org/10.1007/978-3-642-03816-7_4.
ieee: 'K. Chatterjee, T. A. Henzinger, and F. Horn, “Stochastic games with finitary
objectives,” presented at the MFCS: Mathematical Foundations of Computer Science,
High Tatras, Slovakia, 2009, vol. 5734, pp. 34–54.'
ista: 'Chatterjee K, Henzinger TA, Horn F. 2009. Stochastic games with finitary
objectives. MFCS: Mathematical Foundations of Computer Science, LNCS, vol. 5734,
34–54.'
mla: Chatterjee, Krishnendu, et al. Stochastic Games with Finitary Objectives.
Vol. 5734, Springer, 2009, pp. 34–54, doi:10.1007/978-3-642-03816-7_4.
short: K. Chatterjee, T.A. Henzinger, F. Horn, in:, Springer, 2009, pp. 34–54.
conference:
end_date: 2009-08-28
location: High Tatras, Slovakia
name: 'MFCS: Mathematical Foundations of Computer Science'
start_date: 2009-08-24
corr_author: '1'
date_created: 2018-12-11T12:09:24Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2024-10-09T20:53:54Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-03816-7_4
ec_funded: 1
intvolume: ' 5734'
language:
- iso: eng
month: '08'
oa_version: None
page: 34 - 54
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '214373'
name: Design for Embedded Systems
publication_status: published
publisher: Springer
publist_id: '178'
quality_controlled: '1'
scopus_import: 1
status: public
title: Stochastic games with finitary objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5734
year: '2009'
...
---
_id: '4545'
abstract:
- lang: eng
text: 'A stochastic game is a two-player game played oil a graph, where in each
state the successor is chosen either by One of the players, or according to a
probability distribution. We Survey Stochastic games with limsup and liminf objectives.
A real-valued re-ward is assigned to each state, and the value of all infinite
path is the limsup (resp. liminf) of all rewards along the path. The value of
a stochastic game is the maximal expected value of an infinite path that call
he achieved by resolving the decisions of the first player. We present the complexity
of computing values of Stochastic games and their subclasses, and the complexity,
of optimal strategies in such games. '
acknowledgement: This research was supported in part by the Swiss National Science
Foundation under the Indo-Swiss Joint Research Programme, by the European Network
of Excellence on Embedded Systems Design (ArtistDesign), by the European projects
COMBEST, Quasimodo, Gasics, by the PAI program Moves funded by the Belgian Federal
Government, and by the CFV (Federated Center in Verification) funded by the F.R.S.-FNRS.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Chatterjee K, Doyen L, Henzinger TA. A survey of stochastic games with limsup
and liminf objectives. In: Vol 5556. Springer; 2009:1-15. doi:10.1007/978-3-642-02930-1_1'
apa: 'Chatterjee, K., Doyen, L., & Henzinger, T. A. (2009). A survey of stochastic
games with limsup and liminf objectives (Vol. 5556, pp. 1–15). Presented at the
ICALP: Automata, Languages and Programming, Rhodos, Greece: Springer. https://doi.org/10.1007/978-3-642-02930-1_1'
chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “A Survey
of Stochastic Games with Limsup and Liminf Objectives,” 5556:1–15. Springer, 2009.
https://doi.org/10.1007/978-3-642-02930-1_1.
ieee: 'K. Chatterjee, L. Doyen, and T. A. Henzinger, “A survey of stochastic games
with limsup and liminf objectives,” presented at the ICALP: Automata, Languages
and Programming, Rhodos, Greece, 2009, vol. 5556, pp. 1–15.'
ista: 'Chatterjee K, Doyen L, Henzinger TA. 2009. A survey of stochastic games with
limsup and liminf objectives. ICALP: Automata, Languages and Programming, LNCS,
vol. 5556, 1–15.'
mla: Chatterjee, Krishnendu, et al. A Survey of Stochastic Games with Limsup
and Liminf Objectives. Vol. 5556, Springer, 2009, pp. 1–15, doi:10.1007/978-3-642-02930-1_1.
short: K. Chatterjee, L. Doyen, T.A. Henzinger, in:, Springer, 2009, pp. 1–15.
conference:
end_date: 2009-07-12
location: Rhodos, Greece
name: 'ICALP: Automata, Languages and Programming'
start_date: 2009-07-05
corr_author: '1'
date_created: 2018-12-11T12:09:24Z
date_published: 2009-06-24T00:00:00Z
date_updated: 2024-10-09T20:53:54Z
day: '24'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.1007/978-3-642-02930-1_1
ec_funded: 1
file:
- access_level: open_access
checksum: dabb6d24428a000254c95493d9c492e6
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:11Z
date_updated: 2020-07-14T12:46:31Z
file_id: '4992'
file_name: IST-2012-38-v1+1_A_survey_of_stochastic_games_with_limsup_and_liminf_objectives.pdf
file_size: 187419
relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
has_accepted_license: '1'
intvolume: ' 5556'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 1 - 15
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '177'
pubrep_id: '38'
quality_controlled: '1'
scopus_import: 1
status: public
title: A survey of stochastic games with limsup and liminf objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5556
year: '2009'
...
---
_id: '4569'
abstract:
- lang: eng
text: "Most specification languages express only qualitative constraints. However,
among two implementations that satisfy a given specification, one may be preferred
to another. For example, if a specification asks that every request is followed
by a response, one may prefer an implementation that generates responses quickly
but does not generate unnecessary responses. We use quantitative properties to
measure the “goodness” of an implementation. Using games with corresponding quantitative
objectives, we can synthesize “optimal” implementations, which are preferred among
the set of possible implementations that satisfy a given specification.\r\nIn
particular, we show how automata with lexicographic mean-payoff conditions can
be used to express many interesting quantitative properties for reactive systems.
In this framework, the synthesis of optimal implementations requires the solution
of lexicographic mean-payoff games (for safety requirements), and the solution
of games with both lexicographic mean-payoff and parity objectives (for liveness
requirements). We present algorithms for solving both kinds of novel graph games."
acknowledgement: This research was supported by the Swiss National Science Foundation
(Indo-Swiss Research Program and NCCR MICS) and the European Union projects COMBEST
and COCONUT.
alternative_title:
- LNCS
arxiv: 1
author:
- first_name: Roderick
full_name: Bloem, Roderick
last_name: Bloem
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Barbara
full_name: Jobstmann, Barbara
last_name: Jobstmann
citation:
ama: 'Bloem R, Chatterjee K, Henzinger TA, Jobstmann B. Better quality in synthesis
through quantitative objectives. In: Vol 5643. Springer; 2009:140-156. doi:10.1007/978-3-642-02658-4_14'
apa: 'Bloem, R., Chatterjee, K., Henzinger, T. A., & Jobstmann, B. (2009). Better
quality in synthesis through quantitative objectives (Vol. 5643, pp. 140–156).
Presented at the CAV: Computer Aided Verification, Grenoble, France: Springer.
https://doi.org/10.1007/978-3-642-02658-4_14'
chicago: Bloem, Roderick, Krishnendu Chatterjee, Thomas A Henzinger, and Barbara
Jobstmann. “Better Quality in Synthesis through Quantitative Objectives,” 5643:140–56.
Springer, 2009. https://doi.org/10.1007/978-3-642-02658-4_14.
ieee: 'R. Bloem, K. Chatterjee, T. A. Henzinger, and B. Jobstmann, “Better quality
in synthesis through quantitative objectives,” presented at the CAV: Computer
Aided Verification, Grenoble, France, 2009, vol. 5643, pp. 140–156.'
ista: 'Bloem R, Chatterjee K, Henzinger TA, Jobstmann B. 2009. Better quality in
synthesis through quantitative objectives. CAV: Computer Aided Verification, LNCS,
vol. 5643, 140–156.'
mla: Bloem, Roderick, et al. Better Quality in Synthesis through Quantitative
Objectives. Vol. 5643, Springer, 2009, pp. 140–56, doi:10.1007/978-3-642-02658-4_14.
short: R. Bloem, K. Chatterjee, T.A. Henzinger, B. Jobstmann, in:, Springer, 2009,
pp. 140–156.
conference:
end_date: 2009-07-02
location: Grenoble, France
name: 'CAV: Computer Aided Verification'
start_date: 2009-06-26
date_created: 2018-12-11T12:09:31Z
date_published: 2009-06-19T00:00:00Z
date_updated: 2024-10-21T06:03:07Z
day: '19'
department:
- _id: KrCh
doi: 10.1007/978-3-642-02658-4_14
ec_funded: 1
external_id:
arxiv:
- '0904.2638'
intvolume: ' 5643'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/0904.2638
month: '06'
oa: 1
oa_version: Preprint
page: 140 - 156
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '141'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Better quality in synthesis through quantitative objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5643
year: '2009'
...
---
_id: '5392'
abstract:
- lang: eng
text: We consider probabilistic automata on infinite words with acceptance defined
by safety, reachability, Büchi, coBüchi and limit-average conditions. We consider
quantitative and qualitative decision problems. We present extensions and adaptations
of proofs of [GO09] and present a precise characterization of the decidability
and undecidability frontier of the quantitative and qualitative decision problems.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: 'Chatterjee K. Probabilistic Automata on Infinite Words: Decidability and
Undecidability Results. IST Austria; 2009. doi:10.15479/AT:IST-2009-0004'
apa: 'Chatterjee, K. (2009). Probabilistic automata on infinite words: Decidability
and undecidability results. IST Austria. https://doi.org/10.15479/AT:IST-2009-0004'
chicago: 'Chatterjee, Krishnendu. Probabilistic Automata on Infinite Words: Decidability
and Undecidability Results. IST Austria, 2009. https://doi.org/10.15479/AT:IST-2009-0004.'
ieee: 'K. Chatterjee, Probabilistic automata on infinite words: Decidability
and undecidability results. IST Austria, 2009.'
ista: 'Chatterjee K. 2009. Probabilistic automata on infinite words: Decidability
and undecidability results, IST Austria, 17p.'
mla: 'Chatterjee, Krishnendu. Probabilistic Automata on Infinite Words: Decidability
and Undecidability Results. IST Austria, 2009, doi:10.15479/AT:IST-2009-0004.'
short: 'K. Chatterjee, Probabilistic Automata on Infinite Words: Decidability and
Undecidability Results, IST Austria, 2009.'
corr_author: '1'
date_created: 2018-12-12T11:39:04Z
date_published: 2009-11-02T00:00:00Z
date_updated: 2025-04-14T13:37:25Z
day: '02'
ddc:
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2009-0004
file:
- access_level: open_access
checksum: fb7563150231325b00b1718d956f687b
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:54:08Z
date_updated: 2020-07-14T12:46:43Z
file_id: '5530'
file_name: IST-2009-0004_IST-2009-0004.pdf
file_size: 311065
relation: main_file
file_date_updated: 2020-07-14T12:46:43Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '17'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '28'
related_material:
record:
- id: '3857'
relation: later_version
status: public
status: public
title: 'Probabilistic automata on infinite words: Decidability and undecidability
results'
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '5393'
abstract:
- lang: eng
text: Gist is a tool that (a) solves the qualitative analysis problem of turn-based
probabilistic games with ω-regular objectives; and (b) synthesizes reasonable
environment assumptions for synthesis of unrealizable specifications. Our tool
provides efficient implementations of several reduction based techniques to solve
turn-based probabilistic games, and uses the analysis of turn-based probabilistic
games for synthesizing environment assumptions for unrealizable specifications.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Barbara
full_name: Jobstmann, Barbara
last_name: Jobstmann
- first_name: Arjun
full_name: Radhakrishna, Arjun
id: 3B51CAC4-F248-11E8-B48F-1D18A9856A87
last_name: Radhakrishna
citation:
ama: 'Chatterjee K, Henzinger TA, Jobstmann B, Radhakrishna A. Gist: A Solver
for Probabilistic Games. IST Austria; 2009. doi:10.15479/AT:IST-2009-0003'
apa: 'Chatterjee, K., Henzinger, T. A., Jobstmann, B., & Radhakrishna, A. (2009).
Gist: A solver for probabilistic games. IST Austria. https://doi.org/10.15479/AT:IST-2009-0003'
chicago: 'Chatterjee, Krishnendu, Thomas A Henzinger, Barbara Jobstmann, and Arjun
Radhakrishna. Gist: A Solver for Probabilistic Games. IST Austria, 2009.
https://doi.org/10.15479/AT:IST-2009-0003.'
ieee: 'K. Chatterjee, T. A. Henzinger, B. Jobstmann, and A. Radhakrishna, Gist:
A solver for probabilistic games. IST Austria, 2009.'
ista: 'Chatterjee K, Henzinger TA, Jobstmann B, Radhakrishna A. 2009. Gist: A solver
for probabilistic games, IST Austria, 12p.'
mla: 'Chatterjee, Krishnendu, et al. Gist: A Solver for Probabilistic Games.
IST Austria, 2009, doi:10.15479/AT:IST-2009-0003.'
short: 'K. Chatterjee, T.A. Henzinger, B. Jobstmann, A. Radhakrishna, Gist: A Solver
for Probabilistic Games, IST Austria, 2009.'
corr_author: '1'
date_created: 2018-12-12T11:39:05Z
date_published: 2009-10-09T00:00:00Z
date_updated: 2025-04-14T13:37:27Z
day: '09'
ddc:
- '000'
- '005'
department:
- _id: KrCh
- _id: ToHe
doi: 10.15479/AT:IST-2009-0003
file:
- access_level: open_access
checksum: 49551ac552915b17593a14c993845274
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:52:58Z
date_updated: 2020-07-14T12:46:43Z
file_id: '5459'
file_name: IST-2009-0003_IST-2009-0003.pdf
file_size: 386866
relation: main_file
file_date_updated: 2020-07-14T12:46:43Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '12'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '29'
related_material:
record:
- id: '4388'
relation: later_version
status: public
status: public
title: 'Gist: A solver for probabilistic games'
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '5394'
abstract:
- lang: eng
text: We consider two-player games played on graphs with request-response and finitary
Streett objectives. We show these games are PSPACE-hard, improving the previous
known NP-hardness. We also improve the lower bounds on memory required by the
winning strategies for the players.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Florian
full_name: Horn, Florian
id: 37327ACE-F248-11E8-B48F-1D18A9856A87
last_name: Horn
citation:
ama: Chatterjee K, Henzinger TA, Horn F. Improved Lower Bounds for Request-Response
and Finitary Streett Games. IST Austria; 2009. doi:10.15479/AT:IST-2009-0002
apa: Chatterjee, K., Henzinger, T. A., & Horn, F. (2009). Improved lower
bounds for request-response and finitary Streett games. IST Austria. https://doi.org/10.15479/AT:IST-2009-0002
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Florian Horn. Improved
Lower Bounds for Request-Response and Finitary Streett Games. IST Austria,
2009. https://doi.org/10.15479/AT:IST-2009-0002.
ieee: K. Chatterjee, T. A. Henzinger, and F. Horn, Improved lower bounds for
request-response and finitary Streett games. IST Austria, 2009.
ista: Chatterjee K, Henzinger TA, Horn F. 2009. Improved lower bounds for request-response
and finitary Streett games, IST Austria, 11p.
mla: Chatterjee, Krishnendu, et al. Improved Lower Bounds for Request-Response
and Finitary Streett Games. IST Austria, 2009, doi:10.15479/AT:IST-2009-0002.
short: K. Chatterjee, T.A. Henzinger, F. Horn, Improved Lower Bounds for Request-Response
and Finitary Streett Games, IST Austria, 2009.
corr_author: '1'
date_created: 2018-12-12T11:39:05Z
date_published: 2009-09-09T00:00:00Z
date_updated: 2024-10-09T21:08:23Z
day: '09'
ddc:
- '004'
department:
- _id: KrCh
- _id: ToHe
doi: 10.15479/AT:IST-2009-0002
file:
- access_level: open_access
checksum: 1c50a9723fbae1b2c46d18138968efb3
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:50Z
date_updated: 2020-07-14T12:46:43Z
file_id: '5511'
file_name: IST-2009-0002_IST-2009-0002.pdf
file_size: 238091
relation: main_file
file_date_updated: 2020-07-14T12:46:43Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '11'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '30'
status: public
title: Improved lower bounds for request-response and finitary Streett games
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '5395'
abstract:
- lang: eng
text: 'We study observation-based strategies for partially-observable Markov decision
processes (POMDPs) with omega-regular objectives. An observation-based strategy
relies on partial information about the history of a play, namely, on the past
sequence of observa- tions. We consider the qualitative analysis problem: given
a POMDP with an omega-regular objective, whether there is an observation-based
strategy to achieve the objective with probability 1 (almost-sure winning), or
with positive probability (positive winning). Our main results are twofold. First,
we present a complete picture of the computational complexity of the qualitative
analysis of POMDPs with parity objectives (a canonical form to express omega-regular
objectives) and its subclasses. Our contribution consists in establishing several
upper and lower bounds that were not known in literature. Second, we present optimal
bounds (matching upper and lower bounds) on the memory required by pure and randomized
observation-based strategies for the qualitative analysis of POMDPs with parity
objectives and its subclasses.'
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Chatterjee K, Doyen L, Henzinger TA. Qualitative Analysis of Partially-Observable
Markov Decision Processes. IST Austria; 2009. doi:10.15479/AT:IST-2009-0001
apa: Chatterjee, K., Doyen, L., & Henzinger, T. A. (2009). Qualitative analysis
of partially-observable Markov decision processes. IST Austria. https://doi.org/10.15479/AT:IST-2009-0001
chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. Qualitative
Analysis of Partially-Observable Markov Decision Processes. IST Austria, 2009.
https://doi.org/10.15479/AT:IST-2009-0001.
ieee: K. Chatterjee, L. Doyen, and T. A. Henzinger, Qualitative analysis of partially-observable
Markov decision processes. IST Austria, 2009.
ista: Chatterjee K, Doyen L, Henzinger TA. 2009. Qualitative analysis of partially-observable
Markov decision processes, IST Austria, 20p.
mla: Chatterjee, Krishnendu, et al. Qualitative Analysis of Partially-Observable
Markov Decision Processes. IST Austria, 2009, doi:10.15479/AT:IST-2009-0001.
short: K. Chatterjee, L. Doyen, T.A. Henzinger, Qualitative Analysis of Partially-Observable
Markov Decision Processes, IST Austria, 2009.
corr_author: '1'
date_created: 2018-12-12T11:39:05Z
date_published: 2009-09-09T00:00:00Z
date_updated: 2025-04-14T13:37:25Z
day: '09'
ddc:
- '005'
department:
- _id: KrCh
- _id: ToHe
doi: 10.15479/AT:IST-2009-0001
file:
- access_level: open_access
checksum: 04d9cc065cc19598a4e8631c47f1a562
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:25Z
date_updated: 2020-07-14T12:46:43Z
file_id: '5486'
file_name: IST-2009-0001_IST-2009-0001.pdf
file_size: 342088
relation: main_file
file_date_updated: 2020-07-14T12:46:43Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '20'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '31'
related_material:
record:
- id: '3855'
relation: later_version
status: public
status: public
title: Qualitative analysis of partially-observable Markov decision processes
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '3675'
abstract:
- lang: eng
text: "Sex and recombination have long been seen as adaptations that facilitate
natural selection by generating favorable variations. If recombination is to aid
selection, there must be negative linkage disequilibria—favorable alleles must
be found together less often than expected by chance. These negative linkage disequilibria
can be generated directly by selection, but this must involve negative epistasis
of just the right strength, which is not expected, from either experiment or theory.
Random drift provides a more general source of negative associations: Favorable
mutations almost always arise on different genomes, and negative associations
tend to persist, precisely because they shield variation from selection.\r\n\r\nWe
can understand how recombination aids adaptation by determining the maximum possible
rate of adaptation. With unlinked loci, this rate increases only logarithmically
with the influx of favorable mutations. With a linear genome, a scaling argument
shows that in a large population, the rate of adaptive substitution depends only
on the expected rate in the absence of interference, divided by the total rate
of recombination. A two-locus approximation predicts an upper bound on the rate
of substitution, proportional to recombination rate.\r\n\r\nIf associations between
linked loci do impede adaptation, there can be substantial selection for modifiers
that increase recombination. Whether this can account for the maintenance of high
rates of sex and recombination depends on the extent of selection. It is clear
that the rate of species-wide substitutions is typically far too low to generate
appreciable selection for recombination. However, local sweeps within a subdivided
population may be effective."
acknowledgement: Royal Society and the Engineering and Physical Sciences for support
(GR/ T11753/01)
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Why sex and recombination? In: Cold Spring Harbor Symposia on
Quantitative Biology. Vol 74. Cold Spring Harbor Laboratory Press; 2009:187-195.
doi:10.1101/sqb.2009.74.030'
apa: Barton, N. H. (2009). Why sex and recombination? In Cold Spring Harbor Symposia
on Quantitative Biology (Vol. 74, pp. 187–195). Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/sqb.2009.74.030
chicago: Barton, Nicholas H. “Why Sex and Recombination?” In Cold Spring Harbor
Symposia on Quantitative Biology, 74:187–95. Cold Spring Harbor Laboratory
Press, 2009. https://doi.org/10.1101/sqb.2009.74.030.
ieee: N. H. Barton, “Why sex and recombination?,” in Cold Spring Harbor Symposia
on Quantitative Biology, vol. 74, Cold Spring Harbor Laboratory Press, 2009,
pp. 187–195.
ista: 'Barton NH. 2009.Why sex and recombination? In: Cold Spring Harbor Symposia
on Quantitative Biology. vol. 74, 187–195.'
mla: Barton, Nicholas H. “Why Sex and Recombination?” Cold Spring Harbor Symposia
on Quantitative Biology, vol. 74, Cold Spring Harbor Laboratory Press, 2009,
pp. 187–95, doi:10.1101/sqb.2009.74.030.
short: N.H. Barton, in:, Cold Spring Harbor Symposia on Quantitative Biology, Cold
Spring Harbor Laboratory Press, 2009, pp. 187–195.
corr_author: '1'
date_created: 2018-12-11T12:04:33Z
date_published: 2009-11-10T00:00:00Z
date_updated: 2025-09-30T09:56:29Z
day: '10'
department:
- _id: NiBa
doi: 10.1101/sqb.2009.74.030
external_id:
isi:
- '000578380600022'
intvolume: ' 74'
isi: 1
language:
- iso: eng
month: '11'
oa_version: None
page: 187 - 195
publication: Cold Spring Harbor Symposia on Quantitative Biology
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '2708'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Why sex and recombination?
type: book_chapter
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 74
year: '2009'
...
---
_id: '3775'
abstract:
- lang: eng
text: There is a close analogy between statistical thermodynamics and the evolution
of allele frequencies under mutation, selection and random drift. Wright's formula
for the stationary distribution of allele frequencies is analogous to the Boltzmann
distribution in statistical physics. Population size, 2N, plays the role of the
inverse temperature, 1/kT, and determines the magnitude of random fluctuations.
Log mean fitness, View the MathML source, tends to increase under selection, and
is analogous to a (negative) energy; a potential function, U, increases under
mutation in a similar way. An entropy, SH, can be defined which measures the deviation
from the distribution of allele frequencies expected under random drift alone;
the sum View the MathML source gives a free fitness that increases as the population
evolves towards its stationary distribution. Usually, we observe the distribution
of a few quantitative traits that depend on the frequencies of very many alleles.
The mean and variance of such traits are analogous to observable quantities in
statistical thermodynamics. Thus, we can define an entropy, SΩ, which measures
the volume of allele frequency space that is consistent with the observed trait
distribution. The stationary distribution of the traits is View the MathML source;
this applies with arbitrary epistasis and dominance. The entropies SΩ, SH are
distinct, but converge when there are so many alleles that traits fluctuate close
to their expectations. Populations tend to evolve towards states that can be realised
in many ways (i.e., large SΩ), which may lead to a substantial drop below the
adaptive peak; we illustrate this point with a simple model of genetic redundancy.
This analogy with statistical thermodynamics brings together previous ideas in
a general framework, and justifies a maximum entropy approximation to the dynamics
of quantitative traits.
acknowledgement: "This work was supported by a Royal Society/Wolfson Award, and by
grants EP/T11753/01, EP/C546318/01 from the EPSRC.\r\nWe are grateful to M. Cates,
H.P. de Vladar and G. Sella, and to two anonymous referees, for their helpful comments."
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Jason
full_name: Coe, Jason
last_name: Coe
citation:
ama: Barton NH, Coe J. On the application of statistical physics to evolutionary
biology. Journal of Theoretical Biology. 2009;259(2):317-324. doi:10.1016/j.jtbi.2009.03.019
apa: Barton, N. H., & Coe, J. (2009). On the application of statistical physics
to evolutionary biology. Journal of Theoretical Biology. Elsevier. https://doi.org/10.1016/j.jtbi.2009.03.019
chicago: Barton, Nicholas H, and Jason Coe. “On the Application of Statistical Physics
to Evolutionary Biology.” Journal of Theoretical Biology. Elsevier, 2009.
https://doi.org/10.1016/j.jtbi.2009.03.019.
ieee: N. H. Barton and J. Coe, “On the application of statistical physics to evolutionary
biology,” Journal of Theoretical Biology, vol. 259, no. 2. Elsevier, pp.
317–324, 2009.
ista: Barton NH, Coe J. 2009. On the application of statistical physics to evolutionary
biology. Journal of Theoretical Biology. 259(2), 317–324.
mla: Barton, Nicholas H., and Jason Coe. “On the Application of Statistical Physics
to Evolutionary Biology.” Journal of Theoretical Biology, vol. 259, no.
2, Elsevier, 2009, pp. 317–24, doi:10.1016/j.jtbi.2009.03.019.
short: N.H. Barton, J. Coe, Journal of Theoretical Biology 259 (2009) 317–324.
corr_author: '1'
date_created: 2018-12-11T12:05:06Z
date_published: 2009-07-21T00:00:00Z
date_updated: 2025-09-30T09:56:01Z
day: '21'
department:
- _id: NiBa
doi: 10.1016/j.jtbi.2009.03.019
external_id:
isi:
- '000267176100013'
intvolume: ' 259'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://hal.archives-ouvertes.fr/hal-00554594/document
month: '07'
oa: 1
oa_version: Submitted Version
page: 317 - 324
publication: Journal of Theoretical Biology
publication_status: published
publisher: Elsevier
publist_id: '2452'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the application of statistical physics to evolutionary biology
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 259
year: '2009'
...
---
_id: '3780'
abstract:
- lang: eng
text: Why are sinistral snails so rare? Two main hypotheses are that selection acts
against the establishment of new coiling morphs, because dextral and sinistral
snails have trouble mating, or else a developmental constraint prevents the establishment
of sinistrals. We therefore used an isolate of the snail Lymnaea stagnalis, in
which sinistrals are rare, and populations of Partula suturalis, in which sinistrals
are common, as well as a mathematical model, to understand the circumstances by
which new morphs evolve. The main finding is that the sinistral genotype is associated
with reduced egg viability in L. stagnalis, but in P. suturalis individuals of
sinistral and dextral genotype appear equally fecund, implying a lack of a constraint.
As positive frequency-dependent selection against the rare chiral morph in P.
suturalis also operates over a narrow range (< 3%), the results suggest a model
for chiral evolution in snails in which weak positive frequency-dependent selection
may be overcome by a negative frequency-dependent selection, such as reproductive
character displacement. In snails, there is not always a developmental constraint.
As the direction of cleavage, and thus the directional asymmetry of the entire
body, does not generally vary in other Spiralia (annelids, echiurans, vestimentiferans,
sipunculids and nemerteans), it remains an open question as to whether this is
because of a constraint and/or because most taxa do not have a conspicuous external
asymmetry (like a shell) upon which selection can act.
acknowledgement: We owe a great debt to Jim Murray for his many contributions to the
study of Partula, in the field, in the laboratory, in the interpretation of data,
and in generating new ideas about evolution. With pleasure and respect we dedicate
this paper to him. Jim Murray played a leading role in making the collections used
here. We are very grateful also to Ann Clarke and Elizabeth Murray for help with
collecting, to Lorna Stewart for snail dissections, to Joris Koene for the gift
of snails, to Natasha Constant for entering the data, and Takahiro Asami, Edmund
Gittenberger and Gerhard Falkner for establishing the sinistral stock of L. stagnalis.
Comments from an anonymous referee, A. Richard Palmer and the editorial board improved
the manuscript. Work in the field was supported by the Royal Society, The Carnegie
Trust, the Percy Sladen Trust and the National Science Foundation. The Science Research
Council (B/SR/4144), the National Science Foundation (GB-4188), the Royal Society
and the University of Nottingham supported work in the laboratory.
article_processing_charge: No
author:
- first_name: Angus
full_name: Davison, Angus
last_name: Davison
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Bryan
full_name: Clarke, Bryan
last_name: Clarke
citation:
ama: 'Davison A, Barton NH, Clarke B. The effect of chirality phenotype and genotype
on the fecundity and viability of Partula suturalis and Lymnaea stagnalis: Implications
for the evolution of sinistral snails. Journal of Evolutionary Biology.
2009;22(8):1624-1635. doi:10.1111/j.1420-9101.2009.01770.x'
apa: 'Davison, A., Barton, N. H., & Clarke, B. (2009). The effect of chirality
phenotype and genotype on the fecundity and viability of Partula suturalis and
Lymnaea stagnalis: Implications for the evolution of sinistral snails. Journal
of Evolutionary Biology. Wiley. https://doi.org/10.1111/j.1420-9101.2009.01770.x'
chicago: 'Davison, Angus, Nicholas H Barton, and Bryan Clarke. “The Effect of Chirality
Phenotype and Genotype on the Fecundity and Viability of Partula Suturalis and
Lymnaea Stagnalis: Implications for the Evolution of Sinistral Snails.” Journal
of Evolutionary Biology. Wiley, 2009. https://doi.org/10.1111/j.1420-9101.2009.01770.x.'
ieee: 'A. Davison, N. H. Barton, and B. Clarke, “The effect of chirality phenotype
and genotype on the fecundity and viability of Partula suturalis and Lymnaea stagnalis:
Implications for the evolution of sinistral snails,” Journal of Evolutionary
Biology, vol. 22, no. 8. Wiley, pp. 1624–1635, 2009.'
ista: 'Davison A, Barton NH, Clarke B. 2009. The effect of chirality phenotype and
genotype on the fecundity and viability of Partula suturalis and Lymnaea stagnalis:
Implications for the evolution of sinistral snails. Journal of Evolutionary Biology.
22(8), 1624–1635.'
mla: 'Davison, Angus, et al. “The Effect of Chirality Phenotype and Genotype on
the Fecundity and Viability of Partula Suturalis and Lymnaea Stagnalis: Implications
for the Evolution of Sinistral Snails.” Journal of Evolutionary Biology,
vol. 22, no. 8, Wiley, 2009, pp. 1624–35, doi:10.1111/j.1420-9101.2009.01770.x.'
short: A. Davison, N.H. Barton, B. Clarke, Journal of Evolutionary Biology 22 (2009)
1624–1635.
date_created: 2018-12-11T12:05:08Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2025-09-30T09:55:32Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/j.1420-9101.2009.01770.x
external_id:
isi:
- '000268029800006'
file:
- access_level: open_access
checksum: f70c15c6ab9306121d4153a3be0d2346
content_type: application/pdf
creator: dernst
date_created: 2019-02-22T09:21:44Z
date_updated: 2020-07-14T12:46:15Z
file_id: '6044'
file_name: Davison_JEB_v31_2009.pdf
file_size: 2583812
relation: main_file
file_date_updated: 2020-07-14T12:46:15Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 1624 - 1635
publication: Journal of Evolutionary Biology
publication_status: published
publisher: Wiley
publist_id: '2447'
pubrep_id: '553'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The effect of chirality phenotype and genotype on the fecundity and viability
of Partula suturalis and Lymnaea stagnalis: Implications for the evolution of sinistral
snails'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 22
year: '2009'
...
---
_id: '3837'
abstract:
- lang: eng
text: In this paper we extend the work of Alfaro, Henzinger et al. on interface
theories for component-based design. Existing interface theories often fail to
capture functional relations between the inputs and outputs of an interface. For
example, a simple synchronous interface that takes as input a number n ≥ 0 and
returns, at the same time, as output n + 1, cannot be expressed in existing theories.
In this paper we provide a theory of relational interfaces, where such input-output
relations can be captured. Our theory supports synchronous interfaces, both stateless
and stateful. It includes explicit notions of environments and pluggability, and
satisfies fundamental properties such as preservation of refinement by composition,
and characterization of pluggability by refinement. We achieve these properties
by making reasonable restrictions on feedback loops in interface compositions.
acknowledgement: 'This work is supported by the Center for Hybrid and Embedded Software
Systems (CHESS) at UC Berkeley, which receives support from the National Science
Foundation (NSF awards #0720882 (CSR-EHS: PRET) and #0720841 (CSR-CPS)), the U.S.
Army Research Office (ARO #W911NF-07-2-0019), the U.S. Air Force Office of Scientific
Research (MURI #FA9550-06-0312), the Air Force Research Lab (AFRL), the State of
California Micro Program, and the following companies: Agilent, Bosch, Lockheed-Martin,
National Instruments, Thales and Toyota. This work is also supported by the COMBEST
and ArtistDesign projects of the European Union, and the Swiss National Science
Foundation. '
author:
- first_name: Stavros
full_name: Tripakis, Stavros
last_name: Tripakis
- first_name: Ben
full_name: Lickly, Ben
last_name: Lickly
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Edward
full_name: Lee, Edward
last_name: Lee
citation:
ama: 'Tripakis S, Lickly B, Henzinger TA, Lee E. On relational interfaces. In: EMSOFT
’09 Proceedings of the Seventh ACM International Conference on Embedded Software.
ACM; 2009:67-76. doi:10.1145/1629335.1629346'
apa: 'Tripakis, S., Lickly, B., Henzinger, T. A., & Lee, E. (2009). On relational
interfaces. In EMSOFT ’09 Proceedings of the seventh ACM international conference
on Embedded software (pp. 67–76). Grenoble, France: ACM. https://doi.org/10.1145/1629335.1629346'
chicago: Tripakis, Stavros, Ben Lickly, Thomas A Henzinger, and Edward Lee. “On
Relational Interfaces.” In EMSOFT ’09 Proceedings of the Seventh ACM International
Conference on Embedded Software, 67–76. ACM, 2009. https://doi.org/10.1145/1629335.1629346.
ieee: S. Tripakis, B. Lickly, T. A. Henzinger, and E. Lee, “On relational interfaces,”
in EMSOFT ’09 Proceedings of the seventh ACM international conference on Embedded
software, Grenoble, France, 2009, pp. 67–76.
ista: 'Tripakis S, Lickly B, Henzinger TA, Lee E. 2009. On relational interfaces.
EMSOFT ’09 Proceedings of the seventh ACM international conference on Embedded
software. EMSOFT: Embedded Software , 67–76.'
mla: Tripakis, Stavros, et al. “On Relational Interfaces.” EMSOFT ’09 Proceedings
of the Seventh ACM International Conference on Embedded Software, ACM, 2009,
pp. 67–76, doi:10.1145/1629335.1629346.
short: S. Tripakis, B. Lickly, T.A. Henzinger, E. Lee, in:, EMSOFT ’09 Proceedings
of the Seventh ACM International Conference on Embedded Software, ACM, 2009, pp.
67–76.
conference:
end_date: 2009-10-16
location: Grenoble, France
name: 'EMSOFT: Embedded Software '
start_date: 2009-10-12
date_created: 2018-12-11T12:05:26Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2024-10-21T06:03:06Z
day: '01'
ddc:
- '004'
department:
- _id: ToHe
doi: 10.1145/1629335.1629346
ec_funded: 1
file:
- access_level: open_access
checksum: 3a70e21527dfaad2f198549ae5710786
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:57Z
date_updated: 2020-07-14T12:46:16Z
file_id: '5045'
file_name: IST-2012-70-v1+1_On_Relational_Interfaces.pdf
file_size: 310902
relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 67 - 76
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '214373'
name: Design for Embedded Systems
publication: EMSOFT '09 Proceedings of the seventh ACM international conference on
Embedded software
publication_status: published
publisher: ACM
publist_id: '2360'
pubrep_id: '70'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On relational interfaces
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '3841'
abstract:
- lang: eng
text: 'We compare several languages for specifying Markovian population models such
as queuing networks and chemical reaction networks. These languages —matrix descriptions,
stochastic Petri nets, stoichiometric equations, stochastic process algebras,
and guarded command models— all describe continuous-time Markov chains, but they
differ according to important properties, such as compositionality, expressiveness
and succinctness, executability, ease of use, and the support they provide for
checking the well-formedness of a model and for analyzing a model. '
acknowledgement: This research was supported in part by the Excellence Cluster on
Multimodal Computing and Interaction and the Swiss National Science Foundation.
alternative_title:
- LNCS
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Barbara
full_name: Jobstmann, Barbara
last_name: Jobstmann
- first_name: Verena
full_name: Wolf, Verena
last_name: Wolf
citation:
ama: 'Henzinger TA, Jobstmann B, Wolf V. Formalisms for specifying Markovian population
models. In: Vol 5797. Springer; 2009:3-23. doi:10.1007/978-3-642-04420-5_2'
apa: 'Henzinger, T. A., Jobstmann, B., & Wolf, V. (2009). Formalisms for specifying
Markovian population models (Vol. 5797, pp. 3–23). Presented at the RP: Reachability
Problems, Palaiseau, France: Springer. https://doi.org/10.1007/978-3-642-04420-5_2'
chicago: Henzinger, Thomas A, Barbara Jobstmann, and Verena Wolf. “Formalisms for
Specifying Markovian Population Models,” 5797:3–23. Springer, 2009. https://doi.org/10.1007/978-3-642-04420-5_2.
ieee: 'T. A. Henzinger, B. Jobstmann, and V. Wolf, “Formalisms for specifying Markovian
population models,” presented at the RP: Reachability Problems, Palaiseau, France,
2009, vol. 5797, pp. 3–23.'
ista: 'Henzinger TA, Jobstmann B, Wolf V. 2009. Formalisms for specifying Markovian
population models. RP: Reachability Problems, LNCS, vol. 5797, 3–23.'
mla: Henzinger, Thomas A., et al. Formalisms for Specifying Markovian Population
Models. Vol. 5797, Springer, 2009, pp. 3–23, doi:10.1007/978-3-642-04420-5_2.
short: T.A. Henzinger, B. Jobstmann, V. Wolf, in:, Springer, 2009, pp. 3–23.
conference:
end_date: 2009-09-25
location: Palaiseau, France
name: 'RP: Reachability Problems'
start_date: 2009-09-23
date_created: 2018-12-11T12:05:28Z
date_published: 2009-09-07T00:00:00Z
date_updated: 2025-09-30T08:49:00Z
day: '07'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.1007/978-3-642-04420-5_2
file:
- access_level: open_access
checksum: df88431872586c773fbcfea37d7b36a2
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:41Z
date_updated: 2020-07-14T12:46:16Z
file_id: '4702'
file_name: IST-2012-67-v1+1_Formalisms_for_specifying_Markovian_population_models.pdf
file_size: 222840
relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
intvolume: ' 5797'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 3 - 23
publication_status: published
publisher: Springer
publist_id: '2352'
pubrep_id: '67'
quality_controlled: '1'
related_material:
record:
- id: '3381'
relation: later_version
status: public
scopus_import: 1
status: public
title: Formalisms for specifying Markovian population models
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5797
year: '2009'
...
---
_id: '3843'
abstract:
- lang: eng
text: "Within systems biology there is an increasing interest in the stochastic
behavior of biochemical reaction networks. An appropriate stochastic description
is provided by the chemical master equation, which represents a continuous- time
Markov chain (CTMC).\r\nStandard Uniformization (SU) is an efficient method for
the transient analysis of CTMCs. For systems with very different time scales,
such as biochemical reaction networks, SU is computationally expensive. In these
cases, a variant of SU, called adaptive uniformization (AU), is known to reduce
the large number of iterations needed by SU. The additional difficulty of AU is
that it requires the solution of a birth process.\r\nIn this paper we present
an on-the-fly variant of AU, where we improve the original algorithm for AU at
the cost of a small approximation error. By means of several examples, we show
that our approach is particularly well-suited for biochemical reaction networks."
acknowledgement: This research has been partially funded by the Swiss National Science
Foundation under grant 205321-111840 and by the Cluster of Excellence on Multimodal
Computing and Interaction at Saarland University.
article_processing_charge: No
author:
- first_name: Frédéric
full_name: Didier, Frédéric
last_name: Didier
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Maria
full_name: Mateescu, Maria
id: 3B43276C-F248-11E8-B48F-1D18A9856A87
last_name: Mateescu
- first_name: Verena
full_name: Wolf, Verena
last_name: Wolf
citation:
ama: 'Didier F, Henzinger TA, Mateescu M, Wolf V. Fast adaptive uniformization of
the chemical master equation. In: Vol 4. IEEE; 2009:118-127. doi:10.1109/HiBi.2009.23'
apa: 'Didier, F., Henzinger, T. A., Mateescu, M., & Wolf, V. (2009). Fast adaptive
uniformization of the chemical master equation (Vol. 4, pp. 118–127). Presented
at the HIBI: High-Performance Computational Systems Biology, Trento, Italy: IEEE.
https://doi.org/10.1109/HiBi.2009.23'
chicago: Didier, Frédéric, Thomas A Henzinger, Maria Mateescu, and Verena Wolf.
“Fast Adaptive Uniformization of the Chemical Master Equation,” 4:118–27. IEEE,
2009. https://doi.org/10.1109/HiBi.2009.23.
ieee: 'F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization
of the chemical master equation,” presented at the HIBI: High-Performance Computational
Systems Biology, Trento, Italy, 2009, vol. 4, no. 6, pp. 118–127.'
ista: 'Didier F, Henzinger TA, Mateescu M, Wolf V. 2009. Fast adaptive uniformization
of the chemical master equation. HIBI: High-Performance Computational Systems
Biology vol. 4, 118–127.'
mla: Didier, Frédéric, et al. Fast Adaptive Uniformization of the Chemical Master
Equation. Vol. 4, no. 6, IEEE, 2009, pp. 118–27, doi:10.1109/HiBi.2009.23.
short: F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, in:, IEEE, 2009, pp. 118–127.
conference:
end_date: 2009-10-16
location: Trento, Italy
name: 'HIBI: High-Performance Computational Systems Biology'
start_date: 2009-10-14
date_created: 2018-12-11T12:05:28Z
date_published: 2009-10-30T00:00:00Z
date_updated: 2025-09-30T09:54:51Z
day: '30'
ddc:
- '000'
department:
- _id: ToHe
- _id: CaGu
doi: 10.1109/HiBi.2009.23
external_id:
isi:
- '000275038300017'
file:
- access_level: open_access
checksum: 9a3bde48f43203991a0b3c6a277c2f5b
content_type: application/pdf
creator: dernst
date_created: 2020-05-19T16:33:55Z
date_updated: 2020-07-14T12:46:17Z
file_id: '7874'
file_name: 2009_HIBI_Didier.pdf
file_size: 222890
relation: main_file
file_date_updated: 2020-07-14T12:46:17Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '6'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 118 - 127
publication_status: published
publisher: IEEE
publist_id: '2348'
quality_controlled: '1'
related_material:
record:
- id: '3842'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Fast adaptive uniformization of the chemical master equation
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 4
year: '2009'
...
---
_id: '3844'
abstract:
- lang: eng
text: The Hierarchical Timing Language (HTL) is a real-time coordination language
for distributed control systems. HTL programs must be checked for well-formedness,
race freedom, transmission safety (schedulability of inter-host communication),
and time safety (schedulability of host computation). We present a modular abstract
syntax and semantics for HTL, modular checks of well-formedness, race freedom,
and transmission safety, and modular code distribution. Our contributions here
complement previous results on HTL time safety and modular code generation. Modularity
in HTL can be utilized in easy program composition as well as fast program analysis
and code generation, but also in so-called runtime patching, where program components
may be modified at runtime.
acknowledgement: Supported by the EU ArtistDesign Network of Excellence on Embedded
Systems Design, the EU project COMBEST, the Austrian Science Funds P18913-N15 and
V00125, and Fundacao para a Ciencia e Tecnologia funds SFRH/BD/29461/2006 and PTDC/EIA/71462/2006
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Christoph
full_name: Kirsch, Christoph
last_name: Kirsch
- first_name: Eduardo
full_name: Marques, Eduardo
last_name: Marques
- first_name: Ana
full_name: Sokolova, Ana
last_name: Sokolova
citation:
ama: 'Henzinger TA, Kirsch C, Marques E, Sokolova A. Distributed, modular HTL. In:
IEEE; 2009:171-180. doi:10.1109/RTSS.2009.9'
apa: 'Henzinger, T. A., Kirsch, C., Marques, E., & Sokolova, A. (2009). Distributed,
modular HTL (pp. 171–180). Presented at the RTSS: Real-Time Systems Symposium,
Washington, DC, United States: IEEE. https://doi.org/10.1109/RTSS.2009.9'
chicago: Henzinger, Thomas A, Christoph Kirsch, Eduardo Marques, and Ana Sokolova.
“Distributed, Modular HTL,” 171–80. IEEE, 2009. https://doi.org/10.1109/RTSS.2009.9.
ieee: 'T. A. Henzinger, C. Kirsch, E. Marques, and A. Sokolova, “Distributed, modular
HTL,” presented at the RTSS: Real-Time Systems Symposium, Washington, DC, United
States, 2009, pp. 171–180.'
ista: 'Henzinger TA, Kirsch C, Marques E, Sokolova A. 2009. Distributed, modular
HTL. RTSS: Real-Time Systems Symposium, 171–180.'
mla: Henzinger, Thomas A., et al. Distributed, Modular HTL. IEEE, 2009, pp.
171–80, doi:10.1109/RTSS.2009.9.
short: T.A. Henzinger, C. Kirsch, E. Marques, A. Sokolova, in:, IEEE, 2009, pp.
171–180.
conference:
end_date: 2009-12-04
location: Washington, DC, United States
name: 'RTSS: Real-Time Systems Symposium'
start_date: 2009-12-01
date_created: 2018-12-11T12:05:28Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2025-09-30T09:54:22Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1109/RTSS.2009.9
ec_funded: 1
external_id:
isi:
- '000277465500016'
file:
- access_level: open_access
checksum: b2b15a5ef71eb50d62eaa5aea7efd8c4
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:07:56Z
date_updated: 2020-07-14T12:46:17Z
file_id: '4655'
file_name: IST-2012-65-v1+1_Distributed_modular_Htl.pdf
file_size: 526458
relation: main_file
file_date_updated: 2020-07-14T12:46:17Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 171 - 180
project:
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '214373'
name: Design for Embedded Systems
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: IEEE
publist_id: '2346'
pubrep_id: '65'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distributed, modular HTL
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2009'
...
---
_id: '3870'
abstract:
- lang: eng
text: Games on graphs with omega-regular objectives provide a model for the control
and synthesis of reactive systems. Every omega-regular objective can be decomposed
into a safety part and a liveness part. The liveness part ensures that something
good happens “eventually.” Two main strengths of the classical, infinite-limit
formulation of liveness are robustness (independence from the granularity of transitions)
and simplicity (abstraction of complicated time bounds). However, the classical
liveness formulation suffers from the drawback that the time until something good
happens may be unbounded. A stronger formulation of liveness, so-called finitary
liveness, overcomes this drawback, while still retaining robustness and simplicity.
Finitary liveness requires that there exists an unknown, fixed bound b such that
something good happens within b transitions. While for one-shot liveness (reachability)
objectives, classical and finitary liveness coincide, for repeated liveness (Buchi)
objectives, the finitary formulation is strictly stronger. In this work we study
games with finitary parity and Streett objectives. We prove the determinacy of
these games, present algorithms for solving these games, and characterize the
memory requirements of winning strategies. We show that finitary parity games
can be solved in polynomial time, which is not known for infinitary parity games.
For finitary Streett games, we give an EXPTIME algorithm and show that the problem
is NP-hard. Our algorithms can be used, for example, for synthesizing controllers
that do not let the response time of a system increase without bound.
acknowledgement: "This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
the NSF grants CCR-0132780, CNS-0720884, and CCR- 225610, by the Swiss National
Science Foundation, by the COMBEST project of the European Union, and EU-TMR network
Games.\r\nWe thank anonymous reviewers for useful comments."
article_number: '1'
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Florian
full_name: Horn, Florian
id: 37327ACE-F248-11E8-B48F-1D18A9856A87
last_name: Horn
citation:
ama: Chatterjee K, Henzinger TA, Horn F. Finitary winning in omega-regular games.
ACM Transactions on Computational Logic (TOCL). 2009;11(1). doi:10.1145/1614431.1614432
apa: Chatterjee, K., Henzinger, T. A., & Horn, F. (2009). Finitary winning in
omega-regular games. ACM Transactions on Computational Logic (TOCL). ACM.
https://doi.org/10.1145/1614431.1614432
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Florian Horn. “Finitary
Winning in Omega-Regular Games.” ACM Transactions on Computational Logic (TOCL).
ACM, 2009. https://doi.org/10.1145/1614431.1614432.
ieee: K. Chatterjee, T. A. Henzinger, and F. Horn, “Finitary winning in omega-regular
games,” ACM Transactions on Computational Logic (TOCL), vol. 11, no. 1.
ACM, 2009.
ista: Chatterjee K, Henzinger TA, Horn F. 2009. Finitary winning in omega-regular
games. ACM Transactions on Computational Logic (TOCL). 11(1), 1.
mla: Chatterjee, Krishnendu, et al. “Finitary Winning in Omega-Regular Games.” ACM
Transactions on Computational Logic (TOCL), vol. 11, no. 1, 1, ACM, 2009,
doi:10.1145/1614431.1614432.
short: K. Chatterjee, T.A. Henzinger, F. Horn, ACM Transactions on Computational
Logic (TOCL) 11 (2009).
corr_author: '1'
date_created: 2018-12-11T12:05:37Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2025-09-30T09:53:52Z
day: '01'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.1145/1614431.1614432
ec_funded: 1
external_id:
isi:
- '000272039900001'
file:
- access_level: open_access
checksum: 139c4586d24f11e5da31fb3a0cf96ef4
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:08Z
date_updated: 2020-07-14T12:46:20Z
file_id: '5125'
file_name: IST-2012-53-v1+1_Finitary_winning_in_omega-regular_games.pdf
file_size: 180082
relation: main_file
file_date_updated: 2020-07-14T12:46:20Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '215543'
name: COMponent-Based Embedded Systems design Techniques
publication: ACM Transactions on Computational Logic (TOCL)
publication_status: published
publisher: ACM
publist_id: '2309'
pubrep_id: '53'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Finitary winning in omega-regular games
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2009'
...