---
OA_place: repository
OA_type: green
_id: '20193'
abstract:
- lang: eng
  text: Understanding the rapid formation of supermassive black holes in the early
    Universe requires insights into stellar mass growth in host galaxies. Here we
    present NIRSpec rest-frame optical spectra and NIRCam imaging from JWST of two
    galaxies at z > 6, both hosting moderate-luminosity quasars. These galaxies exhibit
    Balmer absorption lines, like low-redshift post-starburst galaxies. Our analyses
    of the medium-resolution spectra and multiband photometry show that the bulk of
    the stellar mass (log(M*/M☉) ≥ 10.6) formed in starburst episodes at redshift
    9 and 7. One of the galaxies shows a clear Balmer break and lacks spatially resolved
    Hα emission. It falls well below the star-formation main sequence at z = 6, indicating
    quiescence. The other is transitioning to quiescence; together, these massive
    galaxies are among the most distant post-starburst systems known. The blueshifted
    wings of the quasar [O iii] emission lines indicate quasar-driven outflow, which
    possibly influences star formation. Direct stellar velocity dispersion measurements
    reveal that one galaxy follows the local black hole mass versus σ* relation whereas
    the other is overmassive. The existence of massive post-starburst galaxies hosting
    billion-solar-mass black holes in short-lived quasar phases indicates that supermassive
    black holes and host galaxies played a principal role in each other’s rapid early
    formation.
acknowledgement: We thank A. C. Carnall for supporting our use of Bagpipes. We thank
  Y. Fu for his help on the use of QSOFitMORE. We thank J. Greene, S. Toft, T. Kakimoto
  and M. Tanaka for fruitful discussions. This work is based on observations made
  with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive for
  Space Telescopes at the Space Telescope Science Institute, which is operated by
  the Association of Universities for Research in Astronomy, under NASA contract NAS
  5-03127 for JWST. These observations are associated with programmes GO 1967 and
  GO 3859. Support for these programmes was provided by NASA through a grant from
  the Space Telescope Science Institute. This work was supported by World Premier
  International Research Center Initiative, MEXT, Japan. This work used computing
  resources at Kavli IPMU. M.O., X.D., J.D.S., Y.M., T.I., K. Ito, K.K. and H.U. are
  supported by the Japan Society for the Promotion of Science (KAKENHI Grant Numbers
  JP24K22894, JP22K14071, JP18H01251, JP22H01262, JP21H04494, JP20K14531, JP23K13141,
  JP17H06130 and JP20H01953). M.O. and K. Inayoshi acknowledge support from the National
  Natural Science Foundation of China (Grant Numbers 12150410307, 12073003, 11721303,
  11991052 and 11950410493). K. Inayoshi acknowledges support from the China Manned
  Space Project (Grant Numbers CMS-CSST-2021-A04 and CMS-CSST-2021-A06). S.E.I.B.
  is funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) under
  Emmy Noether Grant Number BO 5771/1-1. Z.H., T.T. and M.S. acknowledge support from
  the NSF (Grant Numbers AST-2006176, AST-1907208 and AST-2006177). A.L. acknowledges
  funding from MUR (Grant Number PRIN 2022935STW). B.T. acknowledges support from
  the European Research Council (ERC) under the European Union’s Horizon 2020 research
  and innovation programme (Grant Agreement Number 950533) and from the Israel Science
  Foundation (Grant Number 1849/19). F. Walter acknowledges support from the ERC (Grant
  Cosmic_gas). J.-T.S. is supported by the Deutsche Forschungsgemeinschaft (Project
  Number 518006966). M.T. acknowledges support from the NWO (Grant Number 0.16.VIDI.189.162,
  ODIN). S.F. acknowledges support from NASA through the NASA Hubble Fellowship (Grant
  Number HST-HF2-51505.001-A awarded by the Space Telescope Science Institute). K.
  Iwasawa acknowledges support under Grant Number PID2022-136827NB-C44 funded by MCIN/AEI/10.13039/501100011033
  /FEDER, EU. M. Vestergaard gratefully acknowledges financial support from the Independent
  Research Fund Denmark (Grant Numbers DFF 8021-00130 and 3103-00146). F. Wang acknowledges
  support from the NSF (Award Number AST-2513040). R.B. is supported by the SNSF through
  the Ambizione Grant PZ00P2_223532.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Masafusa
  full_name: Onoue, Masafusa
  last_name: Onoue
- first_name: Xuheng
  full_name: Ding, Xuheng
  last_name: Ding
- first_name: John D.
  full_name: Silverman, John D.
  last_name: Silverman
- first_name: Yoshiki
  full_name: Matsuoka, Yoshiki
  last_name: Matsuoka
- first_name: Takuma
  full_name: Izumi, Takuma
  last_name: Izumi
- first_name: Michael A.
  full_name: Strauss, Michael A.
  last_name: Strauss
- first_name: Charlotte
  full_name: Ward, Charlotte
  last_name: Ward
- first_name: Camryn L.
  full_name: Phillips, Camryn L.
  last_name: Phillips
- first_name: Kei
  full_name: Ito, Kei
  last_name: Ito
- first_name: Irham T.
  full_name: Andika, Irham T.
  last_name: Andika
- first_name: Kentaro
  full_name: Aoki, Kentaro
  last_name: Aoki
- first_name: Junya
  full_name: Arita, Junya
  last_name: Arita
- first_name: Shunsuke
  full_name: Baba, Shunsuke
  last_name: Baba
- first_name: Rebekka
  full_name: Bieri, Rebekka
  last_name: Bieri
- first_name: Sarah E.I.
  full_name: Bosman, Sarah E.I.
  last_name: Bosman
- first_name: Anna Christina
  full_name: Eilers, Anna Christina
  last_name: Eilers
- first_name: Seiji
  full_name: Fujimoto, Seiji
  last_name: Fujimoto
- first_name: Melanie
  full_name: Habouzit, Melanie
  last_name: Habouzit
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
  orcid: 0000-0003-3633-5403
- first_name: Masatoshi
  full_name: Imanishi, Masatoshi
  last_name: Imanishi
- first_name: Kohei
  full_name: Inayoshi, Kohei
  last_name: Inayoshi
- first_name: Kazushi
  full_name: Iwasawa, Kazushi
  last_name: Iwasawa
- first_name: Knud
  full_name: Jahnke, Knud
  last_name: Jahnke
- first_name: Nobunari
  full_name: Kashikawa, Nobunari
  last_name: Kashikawa
- first_name: Toshihiro
  full_name: Kawaguchi, Toshihiro
  last_name: Kawaguchi
- first_name: Kotaro
  full_name: Kohno, Kotaro
  last_name: Kohno
- first_name: Chien Hsiu
  full_name: Lee, Chien Hsiu
  last_name: Lee
- first_name: Junyao
  full_name: Li, Junyao
  last_name: Li
- first_name: Alessandro
  full_name: Lupi, Alessandro
  last_name: Lupi
- first_name: Jianwei
  full_name: Lyu, Jianwei
  last_name: Lyu
- first_name: Tohru
  full_name: Nagao, Tohru
  last_name: Nagao
- first_name: Roderik
  full_name: Overzier, Roderik
  last_name: Overzier
- first_name: Jan Torge
  full_name: Schindler, Jan Torge
  last_name: Schindler
- first_name: Malte
  full_name: Schramm, Malte
  last_name: Schramm
- first_name: Matthew T.
  full_name: Scoggins, Matthew T.
  last_name: Scoggins
- first_name: Kazuhiro
  full_name: Shimasaku, Kazuhiro
  last_name: Shimasaku
- first_name: Yoshiki
  full_name: Toba, Yoshiki
  last_name: Toba
- first_name: Benny
  full_name: Trakhtenbrot, Benny
  last_name: Trakhtenbrot
- first_name: Maxime
  full_name: Trebitsch, Maxime
  last_name: Trebitsch
- first_name: Tommaso
  full_name: Treu, Tommaso
  last_name: Treu
- first_name: Hideki
  full_name: Umehata, Hideki
  last_name: Umehata
- first_name: Bram
  full_name: Venemans, Bram
  last_name: Venemans
- first_name: Marianne
  full_name: Vestergaard, Marianne
  last_name: Vestergaard
- first_name: Marta
  full_name: Volonteri, Marta
  last_name: Volonteri
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Feige
  full_name: Wang, Feige
  last_name: Wang
- first_name: Jinyi
  full_name: Yang, Jinyi
  last_name: Yang
- first_name: Haowen
  full_name: Zhang, Haowen
  last_name: Zhang
citation:
  ama: Onoue M, Ding X, Silverman JD, et al. A post-starburst pathway for the formation
    of massive galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. 2025;9:1541-1552.
    doi:<a href="https://doi.org/10.1038/s41550-025-02628-1">10.1038/s41550-025-02628-1</a>
  apa: Onoue, M., Ding, X., Silverman, J. D., Matsuoka, Y., Izumi, T., Strauss, M.
    A., … Zhang, H. (2025). A post-starburst pathway for the formation of massive
    galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. Springer Nature.
    <a href="https://doi.org/10.1038/s41550-025-02628-1">https://doi.org/10.1038/s41550-025-02628-1</a>
  chicago: Onoue, Masafusa, Xuheng Ding, John D. Silverman, Yoshiki Matsuoka, Takuma
    Izumi, Michael A. Strauss, Charlotte Ward, et al. “A Post-Starburst Pathway for
    the Formation of Massive Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>.
    Springer Nature, 2025. <a href="https://doi.org/10.1038/s41550-025-02628-1">https://doi.org/10.1038/s41550-025-02628-1</a>.
  ieee: M. Onoue <i>et al.</i>, “A post-starburst pathway for the formation of massive
    galaxies and black holes at z &#62; 6,” <i>Nature Astronomy</i>, vol. 9. Springer
    Nature, pp. 1541–1552, 2025.
  ista: Onoue M, Ding X, Silverman JD, Matsuoka Y, Izumi T, Strauss MA, Ward C, Phillips
    CL, Ito K, Andika IT, Aoki K, Arita J, Baba S, Bieri R, Bosman SEI, Eilers AC,
    Fujimoto S, Habouzit M, Haiman Z, Imanishi M, Inayoshi K, Iwasawa K, Jahnke K,
    Kashikawa N, Kawaguchi T, Kohno K, Lee CH, Li J, Lupi A, Lyu J, Nagao T, Overzier
    R, Schindler JT, Schramm M, Scoggins MT, Shimasaku K, Toba Y, Trakhtenbrot B,
    Trebitsch M, Treu T, Umehata H, Venemans B, Vestergaard M, Volonteri M, Walter
    F, Wang F, Yang J, Zhang H. 2025. A post-starburst pathway for the formation of
    massive galaxies and black holes at z &#62; 6. Nature Astronomy. 9, 1541–1552.
  mla: Onoue, Masafusa, et al. “A Post-Starburst Pathway for the Formation of Massive
    Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>, vol. 9, Springer
    Nature, 2025, pp. 1541–52, doi:<a href="https://doi.org/10.1038/s41550-025-02628-1">10.1038/s41550-025-02628-1</a>.
  short: M. Onoue, X. Ding, J.D. Silverman, Y. Matsuoka, T. Izumi, M.A. Strauss, C.
    Ward, C.L. Phillips, K. Ito, I.T. Andika, K. Aoki, J. Arita, S. Baba, R. Bieri,
    S.E.I. Bosman, A.C. Eilers, S. Fujimoto, M. Habouzit, Z. Haiman, M. Imanishi,
    K. Inayoshi, K. Iwasawa, K. Jahnke, N. Kashikawa, T. Kawaguchi, K. Kohno, C.H.
    Lee, J. Li, A. Lupi, J. Lyu, T. Nagao, R. Overzier, J.T. Schindler, M. Schramm,
    M.T. Scoggins, K. Shimasaku, Y. Toba, B. Trakhtenbrot, M. Trebitsch, T. Treu,
    H. Umehata, B. Venemans, M. Vestergaard, M. Volonteri, F. Walter, F. Wang, J.
    Yang, H. Zhang, Nature Astronomy 9 (2025) 1541–1552.
date_created: 2025-08-17T22:01:38Z
date_published: 2025-10-01T00:00:00Z
date_updated: 2025-12-30T13:08:12Z
day: '01'
department:
- _id: ZoHa
doi: 10.1038/s41550-025-02628-1
external_id:
  arxiv:
  - '2409.07113'
  isi:
  - '001548138600001'
intvolume: '         9'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2409.07113
month: '10'
oa: 1
oa_version: Preprint
page: 1541-1552
publication: Nature Astronomy
publication_identifier:
  eissn:
  - 2397-3366
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A post-starburst pathway for the formation of massive galaxies and black holes
  at z > 6
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2025'
...
---
OA_place: publisher
_id: '20206'
abstract:
- lang: eng
  text: "The internal structure of biomolecules and their organization in higher-order
    arrangements are key factors governing the working principles of biological systems.
    Bioimaging has successfully revealed arrangements across relevant spatial scales.
    For example, cryo-electron tomography has become widely used for analyzing biomolecular
    structures in situ due to its comprehensive structural visualization of near-natively
    preserved samples, and its capability of sub-nm resolution via averaging. However,
    the identification of molecules within crowded cellular environments is often
    hindered by low contrast. Fluorescence microscopy, on the other hand, routinely
    visualizes specifically labeled targets at single-molecule contrast against essentially
    zero background. Moreover, it provides comparatively high throughput and is amenable
    to multiplexing. Due to this complementarity, combining datasets from both modalities
    acquired on the same region via correlative light and electron microscopy can
    reveal novel types of information. \r\nThe spatial scale at which information
    can be extracted depends on imaging resolution and correlation accuracy. Since
    diffraction of light limits the resolution of conventional fluorescence microscopy
    to few hundreds of nanometers, reaching the full potential of correlative imaging
    requires super-resolution approaches. Performing imaging at cryogenic temperature
    preserves structures in a near-native state and minimizes distortions between
    the fluorescence and the electron microscopy datasets. Implementations of this
    concept have achieved correlation on the scale of cellular organelles or bacterial
    domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule
    scale by improving cryo-super-resolution microscopy, and devising a refined image
    correlation workflow. As part of this project, I constructed a microscopy setup
    and adopted it for super-resolution fluorescence microscopy at room temperature
    and cryogenic conditions. I explored different cryo-stages and acquisition strategies.
    Specifically, I developed a new scheme for correcting sample drift, thus increasing
    mechanical stability during microscopy acquisitions.\r\n"
acknowledged_ssus:
- _id: M-Shop
- _id: EM-Fac
- _id: Bio
acknowledgement: "The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI:
  https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised
  fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989),
  as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary
  Project Committee. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jakob
  full_name: Vorlaufer, Jakob
  id: 937696FA-C996-11E9-8C7C-CF13E6697425
  last_name: Vorlaufer
  orcid: 0009-0000-7590-3501
citation:
  ama: Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in
    situ structure analysis. 2025. doi:<a href="https://doi.org/10.15479/AT-ISTA-20206">10.15479/AT-ISTA-20206</a>
  apa: Vorlaufer, J. (2025). <i>Construction of a cryo-super-resolution microscope
    to guide in situ structure analysis</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT-ISTA-20206">https://doi.org/10.15479/AT-ISTA-20206</a>
  chicago: Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to
    Guide in Situ Structure Analysis.” Institute of Science and Technology Austria,
    2025. <a href="https://doi.org/10.15479/AT-ISTA-20206">https://doi.org/10.15479/AT-ISTA-20206</a>.
  ieee: J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide
    in situ structure analysis,” Institute of Science and Technology Austria, 2025.
  ista: Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide
    in situ structure analysis. Institute of Science and Technology Austria.
  mla: Vorlaufer, Jakob. <i>Construction of a Cryo-Super-Resolution Microscope to
    Guide in Situ Structure Analysis</i>. Institute of Science and Technology Austria,
    2025, doi:<a href="https://doi.org/10.15479/AT-ISTA-20206">10.15479/AT-ISTA-20206</a>.
  short: J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide
    in Situ Structure Analysis, Institute of Science and Technology Austria, 2025.
corr_author: '1'
date_created: 2025-08-22T08:12:55Z
date_published: 2025-08-25T00:00:00Z
date_updated: 2026-04-07T11:48:07Z
day: '25'
ddc:
- '621'
- '535'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoDa
doi: 10.15479/AT-ISTA-20206
file:
- access_level: closed
  checksum: 191db3367c19c9b32b65f4bc3a7c19de
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: jvorlauf
  date_created: 2025-08-25T13:49:55Z
  date_updated: 2025-08-25T13:49:55Z
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  file_name: 2025_Vorlaufer_Jakob_Thesis.docx
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  content_type: application/pdf
  creator: jvorlauf
  date_created: 2025-08-25T13:49:56Z
  date_updated: 2025-08-25T13:49:56Z
  file_id: '20229'
  file_name: 2025_Vorlaufer_Jakob_Thesis.pdf
  file_size: 10947446
  relation: main_file
  success: 1
file_date_updated: 2025-08-25T13:49:56Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '107'
project:
- _id: 62909c6f-2b32-11ec-9570-e1476aab5308
  grant_number: CZI01
  name: CryoMinflux-guided in-situ molecular census and structure determination
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '19795'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
title: Construction of a cryo-super-resolution microscope to guide in situ structure
  analysis
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20217'
abstract:
- lang: eng
  text: "We present Virgil, a Mid-Infrared Instrument (MIRI) extremely red object
    detected with the F1000W filter as part of the MIRI Deep Imaging Survey observations
    of the Hubble Ultra Deep Field. Virgil is an Lyα emitter (LAE) at zspec = 6.6312
    ± 0.0019 (from the Very Large Telescope/MUSE) with a rest-frame UV-to-optical
    spectral energy distribution (SED) typical of LAEs at similar redshifts. However,
    MIRI observations reveal an unexpected extremely red color at rest-frame near-infrared
    (NIR) wavelengths, F444W − F1000W = 2.33 ± 0.06. Such a steep\r\nrise in the NIR,
    completely missed without MIRI imaging, is poorly reproduced by models including
    only stellar populations and hints toward the presence of an active galactic nucleus,
    although alternative explanations such as extreme dust obscuration and strong
    nebular continuum and emission lines contribution due to young stellar ages cannot
    be completely ruled out. According to the shape of its overall SED, Virgil belongs
    to the recently discovered\r\npopulation of little red dots but displays an extended
    rest-frame UV-optical wavelength morphology following a 2DSérsic profile with
    an average index of n = 0.93+0.85_0.31 and re = 0.49+0.05_0.11  pkpc. Only at
    MIRI wavelengths, Virgil is unresolved due to the coarser point-spread function.
    This discovery demonstrates the crucial importance of deep MIRI surveys to reveal
    the true nature and properties of high-z galaxies that otherwise would be misinterpreted
    and raises the question of how common Virgil-like objects could be in the early
    Universe."
acknowledgement: "The authors thank R. Cooper, G. Yang, V. Kokorev, D. Wen, C. Williams,
  and H. Übler for useful discussions and comments.\r\nE.I. and K.I.C. acknowledge
  funding from the Netherlands Research School for Astronomy (NOVA). K.I.C. acknowledges
  funding from the Dutch Research Council (NWO) through the award of the Vici grant
  VI.C.212.036. A.A.-H. acknowledges support from grant PID2021-124665NB-I00 funded
  by MCIN/AEI/10.13039/ 501100011033 and by “ERDF A way of making Europe.” P.G.P.-G.
  acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio
  de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, FEDER Una manera de hacer
  Europa. J.A.-M., A.C.-G., and L.C. acknowledge support by grant PIB2021-127718NB-100
  from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033
  and by “ERDF A way of making Europe.” L.C. thanks the support from the Cosmic Dawn
  Center received during visits to DAWN as an international associate. L.C. acknowledges
  support by grants PIB2021-127718NB-100 and PID2022-139567NB-I00 from the Spanish
  Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033
  and by “ERDF A way of making Europe.” T.R.G. acknowledges support from the Carlsberg
  Foundation (grant No. CF20-0534). S.G. acknowledges financial support from the Cosmic
  Dawn Center (DAWN), funded by the Danish National Research Foundation (DNRF) under
  grant No. 140. This work was supported by research grants (VIL16599, VIL54489) from
  VILLUM FONDEN. J.P.P. and T.V.T. acknowledge financial support from the UK Science
  and Technology Facilities Council and the UK Space Agency.\r\n\r\nThis work is based
  on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data
  were obtained from the MAST at the Space Telescope Science Institute, which is operated
  by the Association of Universities for Research in Astronomy, Inc., under NASA contract
  NAS 5-03127 for JWST. These observations are associated with programs GO #1963,
  GO #1895, and GTO #1283. The authors acknowledge the team led by co-PIs: C. Williams,
  M. Maseda, and S. Tacchella, and PI P. Oesch, for developing their respective observing
  programs with a zero-exclusive-access period. Also based on observations made with
  the NASA/ESA HST obtained from the Space Telescope Science Institute, which is operated
  by the Association of Universities for Research in Astronomy, Inc., under NASA contract
  NAS 5-26555. The work presented here is the effort of the entire MIRI team, and
  the enthusiasm within the MIRI partnership is a significant factor in its success.
  MIRI draws on the scientific and technical expertise of the following organizations:
  Ames Research Center, USA; Airbus Defence and Space, UK; CEA-Irfu, Saclay, France;
  Centre Spatial de Liège, Belgium; Consejo Superior de Investigaciones Científicas,
  Spain; Carl Zeiss Optronics, Germany; Chalmers University of Technology, Sweden;
  Danish Space Research Institute, Denmark; Dublin Institute for Advanced Studies,
  Ireland; European Space Agency, Netherlands; ETCA, Belgium; ETH Zurich, Switzerland;
  Goddard Space Flight Center, USA; Institute d’Astrophysique Spatiale, France; Instituto
  Nacional de Técnica Aeroespacial, Spain; Institute for Astronomy, Edinburgh, UK;
  Jet Propulsion Laboratory, USA; Laboratoire d’Astrophysique de Marseille (LAM),
  France; Leiden University, Netherlands; Lockheed Advanced Technology Center (USA);
  NOVA Opt-IR group at Dwingeloo, Netherlands; Northrop Grumman, USA; Max-Planck Institut
  für Astronomie (MPIA), Heidelberg, Germany; Laboratoire d’Etudes Spatiales et d’Instrumentation
  en Astrophysique (LESIA), France; Paul Scherrer Institut, Switzerland; Raytheon
  Vision Systems, USA; RUAG Aerospace, Switzerland; Rutherford Appleton Laboratory
  (RAL Space), UK; Space Telescope Science Institute, USA; Toegepast-Natuurwetenschappelijk
  Onderzoek (TNO-TPD), Netherlands; UK Astronomy Technology Centre, UK; University
  College London, UK; University of Amsterdam, Netherlands; University of Arizona,
  USA; University of Cardiff, UK; University of Cologne, Germany; University of Ghent;
  University of Groningen, Netherlands; University of Leicester, UK; University of
  Leuven, Belgium; University of Stockholm, Sweden; Utah State University, USA.\r\nFor
  the purpose of open access, the author has applied a Creative Commons Attribution
  (CC BY) licence to the Author Accepted Manuscript version arising from this submission."
article_number: '160'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Edoardo
  full_name: Iani, Edoardo
  id: 4053390a-6b68-11ef-9828-a3b8adef8d0a
  last_name: Iani
  orcid: 0000-0001-8386-3546
- first_name: Pierluigi
  full_name: Rinaldi, Pierluigi
  last_name: Rinaldi
- first_name: Karina I.
  full_name: Caputi, Karina I.
  last_name: Caputi
- first_name: Marianna
  full_name: Annunziatella, Marianna
  last_name: Annunziatella
- first_name: Danial
  full_name: Langeroodi, Danial
  last_name: Langeroodi
- first_name: Jens
  full_name: Melinder, Jens
  last_name: Melinder
- first_name: Pablo G.
  full_name: Pérez-González, Pablo G.
  last_name: Pérez-González
- first_name: Javier
  full_name: Álvarez-Márquez, Javier
  last_name: Álvarez-Márquez
- first_name: Leindert A.
  full_name: Boogaard, Leindert A.
  last_name: Boogaard
- first_name: Sarah E.I.
  full_name: Bosman, Sarah E.I.
  last_name: Bosman
- first_name: Luca
  full_name: Costantin, Luca
  last_name: Costantin
- first_name: Thibaud
  full_name: Moutard, Thibaud
  last_name: Moutard
- first_name: Luis
  full_name: Colina, Luis
  last_name: Colina
- first_name: Göran
  full_name: Östlin, Göran
  last_name: Östlin
- first_name: Thomas R.
  full_name: Greve, Thomas R.
  last_name: Greve
- first_name: Gillian
  full_name: Wright, Gillian
  last_name: Wright
- first_name: Almudena
  full_name: Alonso-Herrero, Almudena
  last_name: Alonso-Herrero
- first_name: Arjan
  full_name: Bik, Arjan
  last_name: Bik
- first_name: Steven
  full_name: Gillman, Steven
  last_name: Gillman
- first_name: Alejandro
  full_name: Crespo Gómez, Alejandro
  last_name: Crespo Gómez
- first_name: Jens
  full_name: Hjorth, Jens
  last_name: Hjorth
- first_name: Sarah
  full_name: Kendrew, Sarah
  last_name: Kendrew
- first_name: Alvaro
  full_name: Labiano, Alvaro
  last_name: Labiano
- first_name: John P.
  full_name: Pye, John P.
  last_name: Pye
- first_name: Tuomo V.
  full_name: Tikkanen, Tuomo V.
  last_name: Tikkanen
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Manuel
  full_name: Güdel, Manuel
  last_name: Güdel
- first_name: Thomas
  full_name: Henning, Thomas
  last_name: Henning
- first_name: Paul P.
  full_name: Van Der Werf, Paul P.
  last_name: Van Der Werf
citation:
  ama: 'Iani E, Rinaldi P, Caputi KI, et al. MIDIS: MIRI uncovers Virgil, the first
    Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. <i>The Astrophysical
    Journal</i>. 2025;989(2). doi:<a href="https://doi.org/10.3847/1538-4357/ade5a6">10.3847/1538-4357/ade5a6</a>'
  apa: 'Iani, E., Rinaldi, P., Caputi, K. I., Annunziatella, M., Langeroodi, D., Melinder,
    J., … Van Der Werf, P. P. (2025). MIDIS: MIRI uncovers Virgil, the first Little
    Red Dot with clear detection of its host galaxy at z ≃ 6.6. <i>The Astrophysical
    Journal</i>. IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ade5a6">https://doi.org/10.3847/1538-4357/ade5a6</a>'
  chicago: 'Iani, Edoardo, Pierluigi Rinaldi, Karina I. Caputi, Marianna Annunziatella,
    Danial Langeroodi, Jens Melinder, Pablo G. Pérez-González, et al. “MIDIS: MIRI
    Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy
    at z ≃ 6.6.” <i>The Astrophysical Journal</i>. IOP Publishing, 2025. <a href="https://doi.org/10.3847/1538-4357/ade5a6">https://doi.org/10.3847/1538-4357/ade5a6</a>.'
  ieee: 'E. Iani <i>et al.</i>, “MIDIS: MIRI uncovers Virgil, the first Little Red
    Dot with clear detection of its host galaxy at z ≃ 6.6,” <i>The Astrophysical
    Journal</i>, vol. 989, no. 2. IOP Publishing, 2025.'
  ista: 'Iani E, Rinaldi P, Caputi KI, Annunziatella M, Langeroodi D, Melinder J,
    Pérez-González PG, Álvarez-Márquez J, Boogaard LA, Bosman SEI, Costantin L, Moutard
    T, Colina L, Östlin G, Greve TR, Wright G, Alonso-Herrero A, Bik A, Gillman S,
    Crespo Gómez A, Hjorth J, Kendrew S, Labiano A, Pye JP, Tikkanen TV, Walter F,
    Güdel M, Henning T, Van Der Werf PP. 2025. MIDIS: MIRI uncovers Virgil, the first
    Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical
    Journal. 989(2), 160.'
  mla: 'Iani, Edoardo, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot
    with Clear Detection of Its Host Galaxy at z ≃ 6.6.” <i>The Astrophysical Journal</i>,
    vol. 989, no. 2, 160, IOP Publishing, 2025, doi:<a href="https://doi.org/10.3847/1538-4357/ade5a6">10.3847/1538-4357/ade5a6</a>.'
  short: E. Iani, P. Rinaldi, K.I. Caputi, M. Annunziatella, D. Langeroodi, J. Melinder,
    P.G. Pérez-González, J. Álvarez-Márquez, L.A. Boogaard, S.E.I. Bosman, L. Costantin,
    T. Moutard, L. Colina, G. Östlin, T.R. Greve, G. Wright, A. Alonso-Herrero, A.
    Bik, S. Gillman, A. Crespo Gómez, J. Hjorth, S. Kendrew, A. Labiano, J.P. Pye,
    T.V. Tikkanen, F. Walter, M. Güdel, T. Henning, P.P. Van Der Werf, The Astrophysical
    Journal 989 (2025).
date_created: 2025-08-24T22:01:29Z
date_published: 2025-08-20T00:00:00Z
date_updated: 2026-02-16T12:43:12Z
day: '20'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ade5a6
external_id:
  arxiv:
  - '2406.18207'
  isi:
  - '001548132000001'
file:
- access_level: open_access
  checksum: 92196e8352dddb1f305c253da1996ab6
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-02T06:40:23Z
  date_updated: 2025-09-02T06:40:23Z
  file_id: '20268'
  file_name: 2025_AstrophysicalJour_Iani.pdf
  file_size: 5474992
  relation: main_file
  success: 1
file_date_updated: 2025-09-02T06:40:23Z
has_accepted_license: '1'
intvolume: '       989'
isi: 1
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection
  of its host galaxy at z ≃ 6.6'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 989
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20220'
abstract:
- lang: eng
  text: Stress granules (SG) are biomolecular condensates that represent an adaptive
    response of cells to various stresses, including heat. However, the cell type–specific
    function and relevance of SG formation, especially during reproductive development,
    are largely not understood. Here, we show that the meiotic A-type cyclin TARDY
    ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis
    after exposure to heat. We find that the amino terminus of TAM is necessary and
    sufficient for the localization of proteins to meiotic SGs. Swapping the amino
    terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function
    allele of TAM, which prevents the partitioning of TAM to SGs while restoring a
    wild-type phenotype in a tam mutant background under nonheat stress conditions.
    Notably, plants expressing this TAM version prematurely terminate meiosis under
    heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs
    is necessary for genome stability under heat stress.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington
  University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa
  (Shimane University, Matsue) for providing the pGWB604 Gateway vector containing
  bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University)
  for the critical reading and comments on this manuscript. We further thank J. Mehrmann
  (Hamburg University) for technical assistance. We thank the ISTA imaging facility
  for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO
  (JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant
  101034413, and a federal grant from the state of Hamburg (LFF-BiCon)."
article_processing_charge: Yes
article_type: original
author:
- first_name: Joke G
  full_name: De Jaeger-Braet, Joke G
  id: 26bd38d3-c59a-11ee-a1af-d7a988cafcc5
  last_name: De Jaeger-Braet
- first_name: Merle
  full_name: Hartmann, Merle
  last_name: Hartmann
- first_name: Lev
  full_name: Böttger, Lev
  last_name: Böttger
- first_name: Chao
  full_name: Yang, Chao
  id: 082e3e6e-8069-11ed-8390-c8cce7b1aaca
  last_name: Yang
- first_name: Takahiro
  full_name: Hamada, Takahiro
  last_name: Hamada
- first_name: Stefan
  full_name: Hoth, Stefan
  last_name: Hoth
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Magdalena
  full_name: Weingartner, Magdalena
  last_name: Weingartner
- first_name: Arp
  full_name: Schnittger, Arp
  last_name: Schnittger
citation:
  ama: De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type
    cyclin TAM to stress granules is crucial for meiotic fidelity under heat. <i>Science
    Advances</i>. 2025;11(32):eadr5694. doi:<a href="https://doi.org/10.1126/sciadv.adr5694">10.1126/sciadv.adr5694</a>
  apa: De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth,
    S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress
    granules is crucial for meiotic fidelity under heat. <i>Science Advances</i>.
    AAAS. <a href="https://doi.org/10.1126/sciadv.adr5694">https://doi.org/10.1126/sciadv.adr5694</a>
  chicago: De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro
    Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The
    Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic
    Fidelity under Heat.” <i>Science Advances</i>. AAAS, 2025. <a href="https://doi.org/10.1126/sciadv.adr5694">https://doi.org/10.1126/sciadv.adr5694</a>.
  ieee: J. G. De Jaeger-Braet <i>et al.</i>, “The recruitment of the A-type cyclin
    TAM to stress granules is crucial for meiotic fidelity under heat,” <i>Science
    Advances</i>, vol. 11, no. 32. AAAS, p. eadr5694, 2025.
  ista: De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng
    X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM
    to stress granules is crucial for meiotic fidelity under heat. Science Advances.
    11(32), eadr5694.
  mla: De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM
    to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” <i>Science Advances</i>,
    vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:<a href="https://doi.org/10.1126/sciadv.adr5694">10.1126/sciadv.adr5694</a>.
  short: J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth,
    X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694.
date_created: 2025-08-24T22:01:30Z
date_published: 2025-08-08T00:00:00Z
date_updated: 2025-09-30T14:24:10Z
day: '08'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1126/sciadv.adr5694
ec_funded: 1
external_id:
  isi:
  - '001549102600016'
file:
- access_level: open_access
  checksum: 0f1ae246acc9b075f01bf4afe382c8ba
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-02T07:05:37Z
  date_updated: 2025-09-02T07:05:37Z
  file_id: '20270'
  file_name: 2025_ScienceAdvance_DeJaegerBraet.pdf
  file_size: 10876817
  relation: main_file
  success: 1
file_date_updated: 2025-09-02T07:05:37Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
issue: '32'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: eadr5694
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: The recruitment of the A-type cyclin TAM to stress granules is crucial for
  meiotic fidelity under heat
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20221'
abstract:
- lang: eng
  text: We describe the design, synthesis, and single-molecule junction conductance
    of π-electron molecules bearing both radial and linear π-conjugation pathways,
    whereby cycloparaphenylene (CPP) radial cores are π-extended linearly with aryl
    alkyne substituents as models for previously reported CPP-arylene ethynylene conjugated
    polymers. Although radially and linearly conjugated molecules have been studied
    previously in isolation as junction-bridging molecular electronic units, this
    is the first study to examine molecules where both topologies are operative. Our
    results reveal that the presence of radial CPP components within the junction-spanning
    pathway leads to a reduction in the conductance of the backbone compared to model
    linear phenyl substituents. Through tight-binding and DFT-based calculations,
    we attribute this conductance change to intramolecular van der Waals (vdW) interactions
    between the CPP ring and the junction-spanning arylene-ethynylene molecular backbone.
    These interactions induce changes in the dihedral angles of the backbone, leading
    to a reduced overlap of π orbitals within the molecular junction.
acknowledgement: We thank Prof. Volker Blum for useful discussions. We thank the Department
  of Energy Office of Basic Energy Science (DE-SC0019017) and the National Science
  Foundation (NSF-DMR 2241180) for supporting this research. This work was supported
  in part by the Institute of Science and Technology Austria.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Wanzhuo
  full_name: Shi, Wanzhuo
  id: a3010425-87c8-11f0-8106-bec32bea74da
  last_name: Shi
- first_name: Mengjiao
  full_name: Wang, Mengjiao
  last_name: Wang
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
- first_name: John D.
  full_name: Tovar, John D.
  last_name: Tovar
citation:
  ama: Shi W, Wang M, Venkataraman L, Tovar JD. Single-molecule conductance through
    hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular
    π-interaction. <i>Nano Letters</i>. 2025;25(31):12101-12106. doi:<a href="https://doi.org/10.1021/acs.nanolett.5c03693">10.1021/acs.nanolett.5c03693</a>
  apa: Shi, W., Wang, M., Venkataraman, L., &#38; Tovar, J. D. (2025). Single-molecule
    conductance through hybrid radially and linearly π-conjugated macromolecules reveals
    an unusual intramolecular π-interaction. <i>Nano Letters</i>. American Chemical
    Society. <a href="https://doi.org/10.1021/acs.nanolett.5c03693">https://doi.org/10.1021/acs.nanolett.5c03693</a>
  chicago: Shi, Wanzhuo, Mengjiao Wang, Latha Venkataraman, and John D. Tovar. “Single-Molecule
    Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals
    an Unusual Intramolecular π-Interaction.” <i>Nano Letters</i>. American Chemical
    Society, 2025. <a href="https://doi.org/10.1021/acs.nanolett.5c03693">https://doi.org/10.1021/acs.nanolett.5c03693</a>.
  ieee: W. Shi, M. Wang, L. Venkataraman, and J. D. Tovar, “Single-molecule conductance
    through hybrid radially and linearly π-conjugated macromolecules reveals an unusual
    intramolecular π-interaction,” <i>Nano Letters</i>, vol. 25, no. 31. American
    Chemical Society, pp. 12101–12106, 2025.
  ista: Shi W, Wang M, Venkataraman L, Tovar JD. 2025. Single-molecule conductance
    through hybrid radially and linearly π-conjugated macromolecules reveals an unusual
    intramolecular π-interaction. Nano Letters. 25(31), 12101–12106.
  mla: Shi, Wanzhuo, et al. “Single-Molecule Conductance through Hybrid Radially and
    Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.”
    <i>Nano Letters</i>, vol. 25, no. 31, American Chemical Society, 2025, pp. 12101–06,
    doi:<a href="https://doi.org/10.1021/acs.nanolett.5c03693">10.1021/acs.nanolett.5c03693</a>.
  short: W. Shi, M. Wang, L. Venkataraman, J.D. Tovar, Nano Letters 25 (2025) 12101–12106.
corr_author: '1'
date_created: 2025-08-24T22:01:30Z
date_published: 2025-07-24T00:00:00Z
date_updated: 2025-09-30T14:23:39Z
day: '24'
ddc:
- '540'
department:
- _id: LaVe
doi: 10.1021/acs.nanolett.5c03693
external_id:
  isi:
  - '001537145800001'
  pmid:
  - '40707400'
file:
- access_level: open_access
  checksum: bfc167d8904c0c47c3de2a8d0ec699d5
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-02T06:50:11Z
  date_updated: 2025-09-02T06:50:11Z
  file_id: '20269'
  file_name: 2025_NanoLetters_Shi.pdf
  file_size: 3212706
  relation: main_file
  success: 1
file_date_updated: 2025-09-02T06:50:11Z
has_accepted_license: '1'
intvolume: '        25'
isi: 1
issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 12101-12106
pmid: 1
publication: Nano Letters
publication_identifier:
  eissn:
  - 1530-6992
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Single-molecule conductance through hybrid radially and linearly π-conjugated
  macromolecules reveals an unusual intramolecular π-interaction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 25
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20223'
abstract:
- lang: eng
  text: The first influential hypothesis for sex chromosome evolution was proposed
    in 1914 by H. J. Muller, who argued that once recombination was suppressed between
    the X and Y chromosomes, Y-linked genes become “sheltered” from selection, leading
    to accumulation of recessive loss-of-function (LOF) mutations and decay of Y-linked
    genes. The hypothesis fell out of favor in the 1970s because early mathematical
    models failed to support it and data on the dominance of lethal mutations were
    viewed as incompatible with the hypothesis. We reevaluate the main arguments against
    Muller's hypothesis and find that they do not conclusively exclude a role for
    sheltering in sex chromosome evolution. By relaxing restrictive assumptions of
    earlier models, we show that sheltering promotes fixation of LOF mutations with
    sexually dimorphic fitness effects, resulting in decay of X-linked genes that
    are exclusively expressed by males and Y-linked genes that are primarily, though
    not necessarily exclusively, expressed by females. We further show that drift
    and other processes contributing to Y degeneration (i.e. selective interference
    and regulatory evolution) expand conditions of Y-linked gene loss by sheltering.
    The actual contribution of sheltering to sex chromosome evolution hinges upon
    the distribution of dominance and sex-specific fitness effects of LOF mutations,
    which we discuss.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank Filip Ruzicka, Colin Olito, Akane Uesugi, Melissa Toups,
  Daniel Jeffries, the Associate Editor, and anonymous reviewers, for comments and
  suggestions on earlier versions of the paper. We are particularly grateful to Deborah
  Charlesworth and Brian Charlesworth for extensive comments on two different drafts
  of the manuscript. We also thank Aneil Agrawal and Thomas Lenormand for email correspondence
  about the data on dominance and ways to interpret it. Technical support was provided
  by ISTA Scientific Computing Unit.
article_number: msaf177
article_processing_charge: Yes
article_type: original
author:
- first_name: Andrea
  full_name: Mrnjavac, Andrea
  id: 353FAC84-AE61-11E9-8BFC-00D3E5697425
  last_name: Mrnjavac
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
- first_name: Tim
  full_name: Connallon, Tim
  last_name: Connallon
citation:
  ama: Mrnjavac A, Vicoso B, Connallon T. An extension of Muller’s sheltering hypothesis
    for the evolution of sex chromosome gene content. <i>Molecular Biology and Evolution</i>.
    2025;42(8). doi:<a href="https://doi.org/10.1093/molbev/msaf177">10.1093/molbev/msaf177</a>
  apa: Mrnjavac, A., Vicoso, B., &#38; Connallon, T. (2025). An extension of Muller’s
    sheltering hypothesis for the evolution of sex chromosome gene content. <i>Molecular
    Biology and Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msaf177">https://doi.org/10.1093/molbev/msaf177</a>
  chicago: Mrnjavac, Andrea, Beatriz Vicoso, and Tim Connallon. “An Extension of Muller’s
    Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” <i>Molecular
    Biology and Evolution</i>. Oxford University Press, 2025. <a href="https://doi.org/10.1093/molbev/msaf177">https://doi.org/10.1093/molbev/msaf177</a>.
  ieee: A. Mrnjavac, B. Vicoso, and T. Connallon, “An extension of Muller’s sheltering
    hypothesis for the evolution of sex chromosome gene content,” <i>Molecular Biology
    and Evolution</i>, vol. 42, no. 8. Oxford University Press, 2025.
  ista: Mrnjavac A, Vicoso B, Connallon T. 2025. An extension of Muller’s sheltering
    hypothesis for the evolution of sex chromosome gene content. Molecular Biology
    and Evolution. 42(8), msaf177.
  mla: Mrnjavac, Andrea, et al. “An Extension of Muller’s Sheltering Hypothesis for
    the Evolution of Sex Chromosome Gene Content.” <i>Molecular Biology and Evolution</i>,
    vol. 42, no. 8, msaf177, Oxford University Press, 2025, doi:<a href="https://doi.org/10.1093/molbev/msaf177">10.1093/molbev/msaf177</a>.
  short: A. Mrnjavac, B. Vicoso, T. Connallon, Molecular Biology and Evolution 42
    (2025).
date_created: 2025-08-24T22:01:31Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-09-30T14:25:57Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/molbev/msaf177
external_id:
  isi:
  - '001547617100001'
  pmid:
  - '40713898'
file:
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  creator: dernst
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  date_updated: 2025-09-02T07:47:32Z
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  file_size: 1239841
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isi: 1
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language:
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month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Biology and Evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://git.ista.ac.at/bvicoso/xydegenerate
scopus_import: '1'
status: public
title: An extension of Muller's sheltering hypothesis for the evolution of sex chromosome
  gene content
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 42
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20224'
abstract:
- lang: eng
  text: "Traffic in datacenters may follow some pattern: some pairs of servers communicate
    more frequently than others. Demand-oblivious networks may perform poorly for
    such workloads, and demand-aware networks optimized for traffic should be used
    instead. Unfortunately, not all shapes of networks are feasible in real hardware.
    Practical limitations are usually provided in the form of a topology. For example,
    a network may be required to be a binary tree, a bounded-degree graph or a Fat
    tree.\r\nIn this work, we consider a topology of a binary tree, one of the most
    fundamental network topologies. We show that already finding an optimal demand-aware
    binary tree network is NP-hard. Then, we explore how various optimization techniques,
    including simple local searches, as well as deterministic mutation and crossover
    operators, cope with generating efficient tree networks on real-life and synthetic
    workloads."
acknowledgement: Research was supported by the German Research Foundation (DFG), grant
  470029389 (FlexNets).
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Pavel
  full_name: Martynov, Pavel
  last_name: Martynov
- first_name: Maxim
  full_name: Buzdalov, Maxim
  last_name: Buzdalov
- first_name: Sergei
  full_name: Pankratov, Sergei
  id: f773bf05-72ef-11ef-b75a-a383d22f454b
  last_name: Pankratov
- first_name: Vitaliy
  full_name: Aksenov, Vitaliy
  last_name: Aksenov
- first_name: Stefan
  full_name: Schmid, Stefan
  last_name: Schmid
citation:
  ama: 'Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. In the search of
    optimal tree networks: Hardness and heuristics. In: <i>Proceedings of the 2025
    Genetic and Evolutionary Computation Conference</i>. Association for Computing
    Machinery; 2025:249-257. doi:<a href="https://doi.org/10.1145/3712256.3726425">10.1145/3712256.3726425</a>'
  apa: 'Martynov, P., Buzdalov, M., Pankratov, S., Aksenov, V., &#38; Schmid, S. (2025).
    In the search of optimal tree networks: Hardness and heuristics. In <i>Proceedings
    of the 2025 Genetic and Evolutionary Computation Conference</i> (pp. 249–257).
    Malaga, Spain: Association for Computing Machinery. <a href="https://doi.org/10.1145/3712256.3726425">https://doi.org/10.1145/3712256.3726425</a>'
  chicago: 'Martynov, Pavel, Maxim Buzdalov, Sergei Pankratov, Vitaliy Aksenov, and
    Stefan Schmid. “In the Search of Optimal Tree Networks: Hardness and Heuristics.”
    In <i>Proceedings of the 2025 Genetic and Evolutionary Computation Conference</i>,
    249–57. Association for Computing Machinery, 2025. <a href="https://doi.org/10.1145/3712256.3726425">https://doi.org/10.1145/3712256.3726425</a>.'
  ieee: 'P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, and S. Schmid, “In the
    search of optimal tree networks: Hardness and heuristics,” in <i>Proceedings of
    the 2025 Genetic and Evolutionary Computation Conference</i>, Malaga, Spain, 2025,
    pp. 249–257.'
  ista: 'Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. 2025. In the search
    of optimal tree networks: Hardness and heuristics. Proceedings of the 2025 Genetic
    and Evolutionary Computation Conference. GECCO: Genetic and evolutionary computation
    conference, 249–257.'
  mla: 'Martynov, Pavel, et al. “In the Search of Optimal Tree Networks: Hardness
    and Heuristics.” <i>Proceedings of the 2025 Genetic and Evolutionary Computation
    Conference</i>, Association for Computing Machinery, 2025, pp. 249–57, doi:<a
    href="https://doi.org/10.1145/3712256.3726425">10.1145/3712256.3726425</a>.'
  short: P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, S. Schmid, in:, Proceedings
    of the 2025 Genetic and Evolutionary Computation Conference, Association for Computing
    Machinery, 2025, pp. 249–257.
conference:
  end_date: 2025-07-18
  location: Malaga, Spain
  name: 'GECCO: Genetic and evolutionary computation conference'
  start_date: 2025-07-14
date_created: 2025-08-24T22:01:31Z
date_published: 2025-07-13T00:00:00Z
date_updated: 2025-12-01T12:35:24Z
day: '13'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1145/3712256.3726425
external_id:
  isi:
  - '001556459900031'
file:
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  checksum: 7e513fa508cff7e8a0d33f50b1fe09af
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  creator: dernst
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language:
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month: '07'
oa: 1
oa_version: Published Version
page: 249-257
publication: Proceedings of the 2025 Genetic and Evolutionary Computation Conference
publication_identifier:
  isbn:
  - '9798400714658'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'In the search of optimal tree networks: Hardness and heuristics'
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
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abstract:
- lang: eng
  text: "We present the first supermartingale certificate for quantitative \r\n-regular
    properties of discrete-time infinite-state stochastic systems. Our certificate
    is defined on the product of the stochastic system and a limit-deterministic Büchi
    automaton that specifies the property of interest; hence we call it a limit-deterministic
    Büchi supermartingale (LDBSM). Previously known supermartingale certificates applied
    only to quantitative reachability, safety, or reach-avoid properties, and to qualitative
    (i.e., probability 1) \r\n-regular properties.We also present fully automated
    algorithms for the template-based synthesis of LDBSMs, for the case when the stochastic
    system dynamics and the controller can be represented in terms of polynomial inequalities.
    Our experiments demonstrate the ability of our method to solve verification and
    control tasks for stochastic systems that were beyond the reach of previous supermartingale-based
    approaches."
acknowledgement: This work was supported in part by the Singapore Ministry of Education
  (MOE) Academic Research Fund (AcRF) Tier 1 grant (Project ID:22-SIS-SMU-100) and
  the ERC project ERC-2020-AdG 101020093.
alternative_title:
- LNCS
article_processing_charge: Yes (in subscription journal)
arxiv: 1
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Kaushik
  full_name: Mallik, Kaushik
  id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598
  last_name: Mallik
  orcid: 0000-0001-9864-7475
- first_name: Pouya
  full_name: Sadeghi, Pouya
  last_name: Sadeghi
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: 'Henzinger TA, Mallik K, Sadeghi P, Zikelic D. Supermartingale certificates
    for quantitative omega-regular verification and control. In: <i>37th International
    Conference on Computer Aided Verification</i>. Vol 15932. Springer Nature; 2025:29-55.
    doi:<a href="https://doi.org/10.1007/978-3-031-98679-6_2">10.1007/978-3-031-98679-6_2</a>'
  apa: 'Henzinger, T. A., Mallik, K., Sadeghi, P., &#38; Zikelic, D. (2025). Supermartingale
    certificates for quantitative omega-regular verification and control. In <i>37th
    International Conference on Computer Aided Verification</i> (Vol. 15932, pp. 29–55).
    Zagreb, Croatia: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-98679-6_2">https://doi.org/10.1007/978-3-031-98679-6_2</a>'
  chicago: Henzinger, Thomas A, Kaushik Mallik, Pouya Sadeghi, and Dorde Zikelic.
    “Supermartingale Certificates for Quantitative Omega-Regular Verification and Control.”
    In <i>37th International Conference on Computer Aided Verification</i>, 15932:29–55.
    Springer Nature, 2025. <a href="https://doi.org/10.1007/978-3-031-98679-6_2">https://doi.org/10.1007/978-3-031-98679-6_2</a>.
  ieee: T. A. Henzinger, K. Mallik, P. Sadeghi, and D. Zikelic, “Supermartingale certificates
    for quantitative omega-regular verification and control,” in <i>37th International
    Conference on Computer Aided Verification</i>, Zagreb, Croatia, 2025, vol. 15932,
    pp. 29–55.
  ista: 'Henzinger TA, Mallik K, Sadeghi P, Zikelic D. 2025. Supermartingale certificates
    for quantitative omega-regular verification and control. 37th International Conference
    on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15932,
    29–55.'
  mla: Henzinger, Thomas A., et al. “Supermartingale Certificates for Quantitative
    Omega-Regular Verification and Control.” <i>37th International Conference on Computer
    Aided Verification</i>, vol. 15932, Springer Nature, 2025, pp. 29–55, doi:<a href="https://doi.org/10.1007/978-3-031-98679-6_2">10.1007/978-3-031-98679-6_2</a>.
  short: T.A. Henzinger, K. Mallik, P. Sadeghi, D. Zikelic, in:, 37th International
    Conference on Computer Aided Verification, Springer Nature, 2025, pp. 29–55.
conference:
  end_date: 2025-07-25
  location: Zagreb, Croatia
  name: 'CAV: Computer Aided Verification'
  start_date: 2025-07-23
date_created: 2025-08-24T22:01:31Z
date_published: 2025-07-22T00:00:00Z
date_updated: 2025-12-01T12:34:41Z
day: '22'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-031-98679-6_2
ec_funded: 1
external_id:
  arxiv:
  - '2505.18833'
  isi:
  - '001562506600002'
file:
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  creator: dernst
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  file_name: 2025_CAV_HenzingerT.pdf
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file_date_updated: 2025-09-02T07:34:33Z
has_accepted_license: '1'
intvolume: '     15932'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 29-55
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: 37th International Conference on Computer Aided Verification
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783031986789'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Supermartingale certificates for quantitative omega-regular verification and control
tmp:
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15932
year: '2025'
...
---
_id: '20242'
abstract:
- lang: eng
  text: "This repository contains calculations of carbon footprints of NMR conferences,
    as described in the article by \r\nLucky N. Kapoor, Natalia Ruzickova, Predrag
    Živadinović, Valentin Leitner, Maria Anna Sisak, Cecelia Mweka, Jeroen Dobbelaere,
    Georgios Katsaros, and Paul Schanda\r\nPublished in Magnetic Resonance, 2025."
article_processing_charge: No
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: 'Schanda P. Data of: “Quantifying the carbon footprint of conference travel:
    the case of NMR meetings.” 2025. doi:<a href="https://doi.org/10.15479/AT-ISTA-20242">10.15479/AT-ISTA-20242</a>'
  apa: 'Schanda, P. (2025). Data of: “Quantifying the carbon footprint of conference
    travel: the case of NMR meetings.” Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT-ISTA-20242">https://doi.org/10.15479/AT-ISTA-20242</a>'
  chicago: 'Schanda, Paul. “Data of: ‘Quantifying the Carbon Footprint of Conference
    Travel: The Case of NMR Meetings.’” Institute of Science and Technology Austria,
    2025. <a href="https://doi.org/10.15479/AT-ISTA-20242">https://doi.org/10.15479/AT-ISTA-20242</a>.'
  ieee: 'P. Schanda, “Data of: ‘Quantifying the carbon footprint of conference travel:
    the case of NMR meetings.’” Institute of Science and Technology Austria, 2025.'
  ista: 'Schanda P. 2025. Data of: ‘Quantifying the carbon footprint of conference
    travel: the case of NMR meetings’, Institute of Science and Technology Austria,
    <a href="https://doi.org/10.15479/AT-ISTA-20242">10.15479/AT-ISTA-20242</a>.'
  mla: 'Schanda, Paul. <i>Data of: “Quantifying the Carbon Footprint of Conference
    Travel: The Case of NMR Meetings.”</i> Institute of Science and Technology Austria,
    2025, doi:<a href="https://doi.org/10.15479/AT-ISTA-20242">10.15479/AT-ISTA-20242</a>.'
  short: P. Schanda, (2025).
contributor:
- contributor_type: researcher
  first_name: Natalia
  id: D2761128-D73D-11E9-A1BF-BA0DE6697425
  last_name: Ruzickova
- contributor_type: researcher
  first_name: Lucky
  id: 84b9700b-15b2-11ec-abd3-831089e67615
  last_name: Kapoor
- contributor_type: researcher
  first_name: Valentin
  id: 4c665ce3-0016-11ec-bea0-e44de7a4fa3d
  last_name: Leitner
- contributor_type: researcher
  first_name: Predrag
  id: 68AA0E5A-AFDA-11E9-9994-141DE6697425
  last_name: Zivadinovic
- contributor_type: researcher
  first_name: Maria A
  id: 44A03D04-AEA4-11E9-B225-EA2DE6697425
  last_name: Sisak
- contributor_type: researcher
  first_name: Cecelia N
  id: 2a69ab4b-896a-11ed-bdf8-cb8641cf2b21
  last_name: Mweka
- contributor_type: supervisor
  first_name: Jeroen A
  id: c15a5412-de82-11ed-b809-8dc1aa996e40
  last_name: Dobbelaere
- contributor_type: supervisor
  first_name: Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
corr_author: '1'
date_created: 2025-08-31T15:14:18Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2026-06-10T08:45:12Z
department:
- _id: PaSc
doi: 10.15479/AT-ISTA-20242
file:
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  file_id: '20263'
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  file_size: 3994
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  success: 1
file_date_updated: 2025-09-01T11:05:27Z
has_accepted_license: '1'
keyword:
- sustainability
- conference travel
month: '09'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
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    relation: used_in_publication
    status: public
status: public
title: 'Data of: "Quantifying the carbon footprint of conference travel: the case
  of NMR meetings"'
tmp:
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type: research_data
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...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20250'
abstract:
- lang: eng
  text: "Population III stars are possible precursors to early supermassive black
    holes (BHs). The presence of soft UV Lyman–Werner (LW) background radiation can
    suppress Population III star formation in minihaloes and allow them to form in
    pristine atomic-cooling haloes. In the absence of molecular hydrogen (⁠H2⁠) cooling,
    atomic-cooling haloes enable rapid collapse with suppressed fragmentation. High
    background LW fluxes from preceding star-formation have been proposed to dissociate
    H2⁠. This flux can be supplemented by LW radiation from one or more Population
    III star(s) in the same halo, reducing the necessary background level. Here, we
    consider atomic-cooling haloes in which multiple protostellar cores form close
    to one another nearly simultaneously. We assess whether the first star’s LW radiation
    can dissociate nearby \r\n⁠, enabling rapid accretion on to a nearby protostellar
    core, and the prompt formation of a second, supermassive star (SMS) from warm,
    atomically-cooled gas. We use a set of hydrodynamical simulations with the code
    enzo, with identical LW backgrounds centred on a halo with two adjacent collapsing
    gas clumps. When an additional large local LW flux is introduced, we observe immediate
    reductions in both the accretion rates and the stellar masses that form within
    these clumps. While the LW flux reduces the H2 fraction and increases the gas
    temperature, the halo core’s potential well is too shallow to promptly heat the
    gas to >1000 K and increase the second protostar’s accretion rate. We conclude
    that this internal LW feedback scenario is unlikely to facilitate SMS or massive
    BH seed formation."
acknowledgement: We thank the anonymous referee for comments that helped us improve
  the clarity of this manuscript. We acknowledge support from the United States National
  Science Foundation (NSF) grant AST-2006176 and the National Aeronautics and Space
  Administration (NASA) grants 80NSSC24K0440 and 80NSSC22K0822 (ZH). We also acknowledge
  support from NSF grant AST-2009309, NASA Astrophysics Theory Program grant 80NSSC22K0629,
  and Space Telescope Science Institute grant JWST-AR-05238 (EV). The simulations
  in this work were run on Texas Advanced Computing Center’s Stampede2 and Stampede3
  systems. We used Stampede2 and Purdue University’s computing system Anvil for data
  analysis.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: James
  full_name: Sullivan, James
  last_name: Sullivan
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
  orcid: 0000-0003-3633-5403
- first_name: Mihir
  full_name: Kulkarni, Mihir
  last_name: Kulkarni
- first_name: Eli
  full_name: Visbal, Eli
  last_name: Visbal
citation:
  ama: Sullivan J, Haiman Z, Kulkarni M, Visbal E. Can supermassive stars form in
    protogalaxies due to internal Lyman-Werner feedback? <i>Monthly Notices of the
    Royal Astronomical Society</i>. 2025;542(2):822-838. doi:<a href="https://doi.org/10.1093/mnras/staf1269">10.1093/mnras/staf1269</a>
  apa: Sullivan, J., Haiman, Z., Kulkarni, M., &#38; Visbal, E. (2025). Can supermassive
    stars form in protogalaxies due to internal Lyman-Werner feedback? <i>Monthly
    Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href="https://doi.org/10.1093/mnras/staf1269">https://doi.org/10.1093/mnras/staf1269</a>
  chicago: Sullivan, James, Zoltán Haiman, Mihir Kulkarni, and Eli Visbal. “Can Supermassive
    Stars Form in Protogalaxies Due to Internal Lyman-Werner Feedback?” <i>Monthly
    Notices of the Royal Astronomical Society</i>. Oxford University Press, 2025.
    <a href="https://doi.org/10.1093/mnras/staf1269">https://doi.org/10.1093/mnras/staf1269</a>.
  ieee: J. Sullivan, Z. Haiman, M. Kulkarni, and E. Visbal, “Can supermassive stars
    form in protogalaxies due to internal Lyman-Werner feedback?,” <i>Monthly Notices
    of the Royal Astronomical Society</i>, vol. 542, no. 2. Oxford University Press,
    pp. 822–838, 2025.
  ista: Sullivan J, Haiman Z, Kulkarni M, Visbal E. 2025. Can supermassive stars form
    in protogalaxies due to internal Lyman-Werner feedback? Monthly Notices of the
    Royal Astronomical Society. 542(2), 822–838.
  mla: Sullivan, James, et al. “Can Supermassive Stars Form in Protogalaxies Due to
    Internal Lyman-Werner Feedback?” <i>Monthly Notices of the Royal Astronomical
    Society</i>, vol. 542, no. 2, Oxford University Press, 2025, pp. 822–38, doi:<a
    href="https://doi.org/10.1093/mnras/staf1269">10.1093/mnras/staf1269</a>.
  short: J. Sullivan, Z. Haiman, M. Kulkarni, E. Visbal, Monthly Notices of the Royal
    Astronomical Society 542 (2025) 822–838.
date_created: 2025-08-31T22:01:31Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2025-09-30T14:28:05Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.1093/mnras/staf1269
external_id:
  arxiv:
  - '2501.12986'
  isi:
  - '001553472000001'
file:
- access_level: open_access
  checksum: 2a06796b27da0b33d479dba170ba4b3f
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-03T05:44:47Z
  date_updated: 2025-09-03T05:44:47Z
  file_id: '20279'
  file_name: 2025_MonthlyNoticesRAS_Sullivan.pdf
  file_size: 2780496
  relation: main_file
  success: 1
file_date_updated: 2025-09-03T05:44:47Z
has_accepted_license: '1'
intvolume: '       542'
isi: 1
issue: '2'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 822-838
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback?
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 542
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20251'
abstract:
- lang: eng
  text: The Lane–Emden inequality controls (math. formular) in terms of the L^1 and
    L^p norms of p. We provide a remainder estimate for this inequality in terms of
    a suitable distance of p to the manifold of optimizers.
acknowledgement: We are grateful to Rupert Frank and Enno Lenzmann for helpful discussions.
article_number: '226'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Eric
  full_name: Carlen, Eric
  last_name: Carlen
- first_name: Mathieu
  full_name: Lewin, Mathieu
  last_name: Lewin
- first_name: Elliott H.
  full_name: Lieb, Elliott H.
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Carlen E, Lewin M, Lieb EH, Seiringer R. Stability estimate for the Lane–Emden
    inequality. <i>Calculus of Variations and Partial Differential Equations</i>.
    2025;64(7). doi:<a href="https://doi.org/10.1007/s00526-025-03062-x">10.1007/s00526-025-03062-x</a>
  apa: Carlen, E., Lewin, M., Lieb, E. H., &#38; Seiringer, R. (2025). Stability estimate
    for the Lane–Emden inequality. <i>Calculus of Variations and Partial Differential
    Equations</i>. Springer Nature. <a href="https://doi.org/10.1007/s00526-025-03062-x">https://doi.org/10.1007/s00526-025-03062-x</a>
  chicago: Carlen, Eric, Mathieu Lewin, Elliott H. Lieb, and Robert Seiringer. “Stability
    Estimate for the Lane–Emden Inequality.” <i>Calculus of Variations and Partial
    Differential Equations</i>. Springer Nature, 2025. <a href="https://doi.org/10.1007/s00526-025-03062-x">https://doi.org/10.1007/s00526-025-03062-x</a>.
  ieee: E. Carlen, M. Lewin, E. H. Lieb, and R. Seiringer, “Stability estimate for
    the Lane–Emden inequality,” <i>Calculus of Variations and Partial Differential
    Equations</i>, vol. 64, no. 7. Springer Nature, 2025.
  ista: Carlen E, Lewin M, Lieb EH, Seiringer R. 2025. Stability estimate for the
    Lane–Emden inequality. Calculus of Variations and Partial Differential Equations.
    64(7), 226.
  mla: Carlen, Eric, et al. “Stability Estimate for the Lane–Emden Inequality.” <i>Calculus
    of Variations and Partial Differential Equations</i>, vol. 64, no. 7, 226, Springer
    Nature, 2025, doi:<a href="https://doi.org/10.1007/s00526-025-03062-x">10.1007/s00526-025-03062-x</a>.
  short: E. Carlen, M. Lewin, E.H. Lieb, R. Seiringer, Calculus of Variations and
    Partial Differential Equations 64 (2025).
date_created: 2025-08-31T22:01:31Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2025-09-30T14:27:35Z
day: '01'
department:
- _id: RoSe
doi: 10.1007/s00526-025-03062-x
external_id:
  arxiv:
  - '2410.20113'
  isi:
  - '001558641300006'
intvolume: '        64'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2410.20113
month: '09'
oa: 1
oa_version: Preprint
publication: Calculus of Variations and Partial Differential Equations
publication_identifier:
  eissn:
  - 1432-0835
  issn:
  - 0944-2669
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stability estimate for the Lane–Emden inequality
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 64
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20252'
abstract:
- lang: eng
  text: Zirconia nanocrystals (ZrO2 NCs) are a stable host material for lanthanides,
    but their performance lags behind that of the leading NaYF4 nanomaterials. Here,
    we leverage surface chemistry and core/shell architectures to uncover the contribution
    of dopants at the nanocrystal surface and of dopants in the nanocrystal bulk.
    We first assess the doping efficiency by ICP and find that, while Eu is almost
    quantitatively incorporated, the other lanthanides (La, Ce, Tb, Tm, Er, Yb) have
    about 50% incorporation efficiency over the studied doping range of 1–10%. We
    then determine the nanocrystal surface chemistry using NMR spectroscopy, despite
    the additional spectral line broadening caused by the paramagnetic lanthanide
    dopants. By varying the surface ligands and measuring the photoluminescence, we
    resolve the spectroscopic signals that are sensitive to a change in surface chemistry.
    Time-resolved emission spectra further reinforce the notion of a bulk component
    with a long luminescent lifetime and a surface component with a fast lifetime.
    Upon shelling Eu- or Tb-doped zirconia NCs with pure zirconia, the surface component
    disappears, and the photoluminescence quantum yield increases. We further functionalized
    the surface of the core/shell particles with oleylphosphonic acid ligands to obtain
    excellent dispersibility. These results show that lanthanide-doped zirconia NCs
    can be engineered to eliminate deactivation pathways.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: N.R. and C.S. thank the SNSF Eccellenza funding scheme (Project 194172)
  for funding. D.V.d.H. is supported by the Research Foundation Flanders (FWO) through
  a Senior Postdoctoral Research Fellowship (N° 1237825N). P.F.S. acknowledges the
  Special Research Fund at UGent (bof/baf/4y/2024/01/037). M.I. acknowledges financial
  support from ISTA and the Werner Siemens Foundation. This research was supported
  by the Scientific Service Units (SSU) of ISTA Austria through resources provided
  by the electron microscopy facility (EMF). We thank Tommaso Costanzo for providing
  assistance during STEM measurements. We acknowledge DESY (Hamburg, Germany), a member
  of the Helmholtz Association HGF, for the provision of experimental facilities.
  Parts of this research were carried out using beamline P21.1 at PETRA III, and the
  authors thank Ann-Christin Dippel, Jiatu Liu, and Fernando Igoa for assistance in
  using the beamline for PDF acquisition (Proposal I-20231114 EC). The authors thank
  Daniel Häussinger for help with the analysis of NMR spectra.
article_processing_charge: No
article_type: original
author:
- first_name: Nico
  full_name: Reichholf, Nico
  last_name: Reichholf
- first_name: Sharona
  full_name: Horta, Sharona
  id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
  last_name: Horta
- first_name: David
  full_name: Van Der Heggen, David
  last_name: Van Der Heggen
- first_name: Carlotta
  full_name: Seno, Carlotta
  last_name: Seno
- first_name: Jikson
  full_name: Pulparayil Mathew, Jikson
  last_name: Pulparayil Mathew
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Philippe F.
  full_name: Smet, Philippe F.
  last_name: Smet
- first_name: Jonathan
  full_name: De Roo, Jonathan
  last_name: De Roo
citation:
  ama: Reichholf N, Horta S, Van Der Heggen D, et al. Identification and elimination
    of surface emission in lanthanide (Co)doped zirconia nanocrystals. <i>ACS Nano</i>.
    2025;19(33):30371-30382. doi:<a href="https://doi.org/10.1021/acsnano.5c09137">10.1021/acsnano.5c09137</a>
  apa: Reichholf, N., Horta, S., Van Der Heggen, D., Seno, C., Pulparayil Mathew,
    J., Ibáñez, M., … De Roo, J. (2025). Identification and elimination of surface
    emission in lanthanide (Co)doped zirconia nanocrystals. <i>ACS Nano</i>. American
    Chemical Society. <a href="https://doi.org/10.1021/acsnano.5c09137">https://doi.org/10.1021/acsnano.5c09137</a>
  chicago: Reichholf, Nico, Sharona Horta, David Van Der Heggen, Carlotta Seno, Jikson
    Pulparayil Mathew, Maria Ibáñez, Philippe F. Smet, and Jonathan De Roo. “Identification
    and Elimination of Surface Emission in Lanthanide (Co)Doped Zirconia Nanocrystals.”
    <i>ACS Nano</i>. American Chemical Society, 2025. <a href="https://doi.org/10.1021/acsnano.5c09137">https://doi.org/10.1021/acsnano.5c09137</a>.
  ieee: N. Reichholf <i>et al.</i>, “Identification and elimination of surface emission
    in lanthanide (Co)doped zirconia nanocrystals,” <i>ACS Nano</i>, vol. 19, no.
    33. American Chemical Society, pp. 30371–30382, 2025.
  ista: Reichholf N, Horta S, Van Der Heggen D, Seno C, Pulparayil Mathew J, Ibáñez
    M, Smet PF, De Roo J. 2025. Identification and elimination of surface emission
    in lanthanide (Co)doped zirconia nanocrystals. ACS Nano. 19(33), 30371–30382.
  mla: Reichholf, Nico, et al. “Identification and Elimination of Surface Emission
    in Lanthanide (Co)Doped Zirconia Nanocrystals.” <i>ACS Nano</i>, vol. 19, no.
    33, American Chemical Society, 2025, pp. 30371–82, doi:<a href="https://doi.org/10.1021/acsnano.5c09137">10.1021/acsnano.5c09137</a>.
  short: N. Reichholf, S. Horta, D. Van Der Heggen, C. Seno, J. Pulparayil Mathew,
    M. Ibáñez, P.F. Smet, J. De Roo, ACS Nano 19 (2025) 30371–30382.
date_created: 2025-08-31T22:01:31Z
date_published: 2025-08-26T00:00:00Z
date_updated: 2025-09-30T14:27:03Z
day: '26'
department:
- _id: MaIb
doi: 10.1021/acsnano.5c09137
external_id:
  isi:
  - '001550173000001'
intvolume: '        19'
isi: 1
issue: '33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.26434/chemrxiv-2025-r1gw4
month: '08'
oa: 1
oa_version: Preprint
page: 30371-30382
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
  name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
    Semiconductors for Waste Heat Recovery'
publication: ACS Nano
publication_identifier:
  eissn:
  - 1936-086X
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification and elimination of surface emission in lanthanide (Co)doped
  zirconia nanocrystals
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 19
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '20253'
abstract:
- lang: eng
  text: "A quantitative word automaton (QWA) defines a function from infinite words
    to values. For example, every infinite run of a limit-average QWA \U0001D49C obtains
    a mean payoff, and every word w ∈ Σ^ω is assigned the maximal mean payoff obtained
    by nondeterministic runs of \U0001D49C over w. We introduce quantitative language
    automata (QLAs) that define functions from language generators (i.e., implementations)
    to values, where a language generator can be nonprobabilistic, defining a set
    of infinite words, or probabilistic, defining a probability measure over infinite
    words. A QLA consists of a QWA and an aggregator function. For example, given
    a QWA \U0001D49C, the infimum aggregator maps each language L ⊆ Σ^ω to the greatest
    lower bound assigned by \U0001D49C to any word in L. For boolean value sets, QWAs
    define boolean properties of traces, and QLAs define boolean properties of sets
    of traces, i.e., hyperproperties. For more general value sets, QLAs serve as a
    specification language for a generalization of hyperproperties, called quantitative
    hyperproperties. A nonprobabilistic (resp. probabilistic) quantitative hyperproperty
    assigns a value to each set (resp. distribution) G of traces, e.g., the minimal
    (resp. expected) average response time exhibited by the traces in G. We give several
    examples of quantitative hyperproperties and investigate three paradigmatic problems
    for QLAs: evaluation, nonemptiness, and universality. In the evaluation problem,
    given a QLA \U0001D538 and an implementation G, we ask for the value that \U0001D538
    assigns to G. In the nonemptiness (resp. universality) problem, given a QLA \U0001D538
    and a value k, we ask whether \U0001D538 assigns at least k to some (resp. every)
    language. We provide a comprehensive picture of decidability for these problems
    for QLAs with common aggregators as well as their restrictions to ω-regular languages
    and trace distributions generated by finite-state Markov chains."
acknowledgement: This work was supported in part by the ERC-2020-AdG 101020093.
alternative_title:
- LIPIcs
article_number: '21'
article_processing_charge: No
arxiv: 1
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Pavol
  full_name: Kebis, Pavol
  id: 2e0132b3-4e98-11ef-b275-cf7281c2802a
  last_name: Kebis
- first_name: Nicolas Adrien
  full_name: Mazzocchi, Nicolas Adrien
  id: b26baa86-3308-11ec-87b0-8990f34baa85
  last_name: Mazzocchi
- first_name: Naci E
  full_name: Sarac, Naci E
  id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
  last_name: Sarac
citation:
  ama: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. Quantitative language automata.
    In: <i>36th International Conference on Concurrency Theory</i>. Vol 348. Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik; 2025. doi:<a href="https://doi.org/10.4230/LIPIcs.CONCUR.2025.21">10.4230/LIPIcs.CONCUR.2025.21</a>'
  apa: 'Henzinger, T. A., Kebis, P., Mazzocchi, N. A., &#38; Sarac, N. E. (2025).
    Quantitative language automata. In <i>36th International Conference on Concurrency
    Theory</i> (Vol. 348). Aarhus, Denmark: Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik. <a href="https://doi.org/10.4230/LIPIcs.CONCUR.2025.21">https://doi.org/10.4230/LIPIcs.CONCUR.2025.21</a>'
  chicago: Henzinger, Thomas A, Pavol Kebis, Nicolas Adrien Mazzocchi, and Naci E
    Sarac. “Quantitative Language Automata.” In <i>36th International Conference on
    Concurrency Theory</i>, Vol. 348. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2025. <a href="https://doi.org/10.4230/LIPIcs.CONCUR.2025.21">https://doi.org/10.4230/LIPIcs.CONCUR.2025.21</a>.
  ieee: T. A. Henzinger, P. Kebis, N. A. Mazzocchi, and N. E. Sarac, “Quantitative
    language automata,” in <i>36th International Conference on Concurrency Theory</i>,
    Aarhus, Denmark, 2025, vol. 348.
  ista: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. 2025. Quantitative language
    automata. 36th International Conference on Concurrency Theory. CONCUR: Conference
    on Concurrency Theory, LIPIcs, vol. 348, 21.'
  mla: Henzinger, Thomas A., et al. “Quantitative Language Automata.” <i>36th International
    Conference on Concurrency Theory</i>, vol. 348, 21, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2025, doi:<a href="https://doi.org/10.4230/LIPIcs.CONCUR.2025.21">10.4230/LIPIcs.CONCUR.2025.21</a>.
  short: T.A. Henzinger, P. Kebis, N.A. Mazzocchi, N.E. Sarac, in:, 36th International
    Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2025.
conference:
  end_date: 2025-08-29
  location: Aarhus, Denmark
  name: 'CONCUR: Conference on Concurrency Theory'
  start_date: 2025-08-26
corr_author: '1'
date_created: 2025-08-31T22:01:32Z
date_published: 2025-08-18T00:00:00Z
date_updated: 2025-12-01T12:36:52Z
day: '18'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.4230/LIPIcs.CONCUR.2025.21
ec_funded: 1
external_id:
  arxiv:
  - '2506.0515'
  isi:
  - '001570540800021'
file:
- access_level: open_access
  checksum: 9d4054058757a73477e6015b10ed6996
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-03T10:01:53Z
  date_updated: 2025-09-03T10:01:53Z
  file_id: '20282'
  file_name: 2025_CONCUR_HenzingerT.pdf
  file_size: 1257397
  relation: main_file
  success: 1
file_date_updated: 2025-09-03T10:01:53Z
has_accepted_license: '1'
intvolume: '       348'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: 36th International Conference on Concurrency Theory
publication_identifier:
  isbn:
  - '9783959773898'
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantitative language automata
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 348
year: '2025'
...
---
APC_amount: 4493,27 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20254'
abstract:
- lang: eng
  text: 'We examine population structures for their ability to maintain diversity
    in neutral evolution. We use the general framework of evolutionary graph theory
    and consider birth–death (bd) and death–birth (db) updating. The population is
    of size N. Initially all individuals represent different types. The basic question
    is: what is the time TN until one type takes over the population? This time is
    known as consensus time in computer science and as total coalescent time in evolutionary
    biology. For the complete graph, it is known that TN is quadratic in N for db
    and bd. For the cycle, we prove that TN is cubic in N for db and bd. For the star,
    we prove that TN is cubic for bd and quasilinear (N log N) for db. For the double
    star, we show that TN is quartic for bd. We derive upper and lower bounds for
    all undirected graphs for bd and db. We also show the Pareto front of graphs (of
    size N = 8) that maintain diversity the longest for bd and db. Further, we show
    that some graphs that quickly homogenize can maintain high levels of diversity
    longer than graphs that slowly homogenize. For directed graphs, we give simple
    contracting star-like structures that have superexponential time scales for maintaining
    diversity.'
acknowledgement: J.S. and K.C. were supported by the European Research Council CoG
  863818 (ForM-SMArt) and Austrian Science Fund 10.55776/COE12. J.T. was supported
  by GAČR grant 25-17377S and by Charles Univ. projects UNCE 24/SCI/008 and PRIMUS
  24/SCI/012.
article_number: pgaf252
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: David A.
  full_name: Brewster, David A.
  last_name: Brewster
- first_name: Jakub
  full_name: Svoboda, Jakub
  id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
  last_name: Svoboda
  orcid: 0000-0002-1419-3267
- first_name: Dylan
  full_name: Roscow, Dylan
  last_name: Roscow
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
- first_name: Martin A.
  full_name: Nowak, Martin A.
  last_name: Nowak
citation:
  ama: Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. Maintaining
    diversity in structured populations. <i>PNAS Nexus</i>. 2025;4(8). doi:<a href="https://doi.org/10.1093/pnasnexus/pgaf252">10.1093/pnasnexus/pgaf252</a>
  apa: Brewster, D. A., Svoboda, J., Roscow, D., Chatterjee, K., Tkadlec, J., &#38;
    Nowak, M. A. (2025). Maintaining diversity in structured populations. <i>PNAS
    Nexus</i>. Oxford University Press. <a href="https://doi.org/10.1093/pnasnexus/pgaf252">https://doi.org/10.1093/pnasnexus/pgaf252</a>
  chicago: Brewster, David A., Jakub Svoboda, Dylan Roscow, Krishnendu Chatterjee,
    Josef Tkadlec, and Martin A. Nowak. “Maintaining Diversity in Structured Populations.”
    <i>PNAS Nexus</i>. Oxford University Press, 2025. <a href="https://doi.org/10.1093/pnasnexus/pgaf252">https://doi.org/10.1093/pnasnexus/pgaf252</a>.
  ieee: D. A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, and M. A.
    Nowak, “Maintaining diversity in structured populations,” <i>PNAS Nexus</i>, vol.
    4, no. 8. Oxford University Press, 2025.
  ista: Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. 2025.
    Maintaining diversity in structured populations. PNAS Nexus. 4(8), pgaf252.
  mla: Brewster, David A., et al. “Maintaining Diversity in Structured Populations.”
    <i>PNAS Nexus</i>, vol. 4, no. 8, pgaf252, Oxford University Press, 2025, doi:<a
    href="https://doi.org/10.1093/pnasnexus/pgaf252">10.1093/pnasnexus/pgaf252</a>.
  short: D.A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, M.A. Nowak,
    PNAS Nexus 4 (2025).
date_created: 2025-08-31T22:01:32Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2026-06-11T09:11:17Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1093/pnasnexus/pgaf252
ec_funded: 1
external_id:
  arxiv:
  - '2503.09841'
file:
- access_level: open_access
  checksum: 8a5e82c6f842e3220ec96028c9374b69
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-03T06:20:08Z
  date_updated: 2025-09-03T06:20:08Z
  file_id: '20280'
  file_name: 2025_PNASNexus_Brewster.pdf
  file_size: 1086419
  relation: main_file
  success: 1
file_date_updated: 2025-09-03T06:20:08Z
has_accepted_license: '1'
intvolume: '         4'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: PNAS Nexus
publication_identifier:
  eissn:
  - 2752-6542
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maintaining diversity in structured populations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20255'
abstract:
- lang: eng
  text: With stunning clarity, the JWST has revealed the Universe’s first billion
    years. The scientific community is analysing a wealth of JWST imaging and spectroscopic
    data from that era, and is in the process of rewriting the astronomy textbooks.
    Here, as a result of the 2024 ISSI Breakthrough Workshop, we provide a snapshot
    of the great progress made towards understanding the initial chapters of our cosmic
    history 1.5 years into the JWST science mission. We present the current census
    of early galaxies, their luminosities, appearance, chemical composition, masses
    and formation histories as revealed by JWST. We relate the discovery of massive
    black holes in early galaxies and discuss their demographics and implications
    for their formations and growth. We conclude by describing the potential sources
    of reionization and our current understanding of how the Universe became fully
    ionized. Throughout the Perspective, we highlight discoveries and breakthroughs,
    topics and issues that are not yet understood, and questions that will be addressed
    in the coming years, as JWST continues its revolutionary observations of the early
    Universe.
acknowledgement: While this Perspective is written by a small number of authors, invited
  to ISSI Bern in March 2024 as part of the 2024 ISSI Breakthrough Workshop, we acknowledge
  the work of a large community that is advancing our collective understanding of
  the evolution of the early Universe. We thank ISSI for sponsoring the 2024 Breakthrough
  Workshop, and the ISSI staff for their wonderful welcome and support. We are grateful
  to the author collaborators, who made this paper possible. Collectively, we are
  grateful to the large group of committed scientists and engineers, worldwide, who
  designed, built and commissioned the JWST and made a decades-long astronomer dream
  a reality. R.P.N. is a NASA Hubble Fellow. We are grateful to M. Dickinson for a
  careful read of the final paper and to F. Crameri (ISSI) for his expert help designing
  the very best figures. We dedicate this paper to the 20,000 people who spent decades
  to make JWST an incredible discovery machine.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Angela
  full_name: Adamo, Angela
  last_name: Adamo
- first_name: Hakim
  full_name: Atek, Hakim
  last_name: Atek
- first_name: Micaela B.
  full_name: Bagley, Micaela B.
  last_name: Bagley
- first_name: Eduardo
  full_name: Bañados, Eduardo
  last_name: Bañados
- first_name: Kirk S.S.
  full_name: Barrow, Kirk S.S.
  last_name: Barrow
- first_name: Danielle A.
  full_name: Berg, Danielle A.
  last_name: Berg
- first_name: Rachel
  full_name: Bezanson, Rachel
  last_name: Bezanson
- first_name: Maruša
  full_name: Bradač, Maruša
  last_name: Bradač
- first_name: Gabriel
  full_name: Brammer, Gabriel
  last_name: Brammer
- first_name: Adam C.
  full_name: Carnall, Adam C.
  last_name: Carnall
- first_name: John
  full_name: Chisholm, John
  last_name: Chisholm
- first_name: Dan
  full_name: Coe, Dan
  last_name: Coe
- first_name: Pratika
  full_name: Dayal, Pratika
  last_name: Dayal
- first_name: Daniel J.
  full_name: Eisenstein, Daniel J.
  last_name: Eisenstein
- first_name: Jan J.
  full_name: Eldridge, Jan J.
  last_name: Eldridge
- first_name: Andrea
  full_name: Ferrara, Andrea
  last_name: Ferrara
- first_name: Seiji
  full_name: Fujimoto, Seiji
  last_name: Fujimoto
- first_name: Anna De
  full_name: Graaff, Anna De
  last_name: Graaff
- first_name: Melanie
  full_name: Habouzit, Melanie
  last_name: Habouzit
- first_name: Taylor A.
  full_name: Hutchison, Taylor A.
  last_name: Hutchison
- first_name: Jeyhan S.
  full_name: Kartaltepe, Jeyhan S.
  last_name: Kartaltepe
- first_name: Susan A.
  full_name: Kassin, Susan A.
  last_name: Kassin
- first_name: Mariska
  full_name: Kriek, Mariska
  last_name: Kriek
- first_name: Ivo
  full_name: Labbé, Ivo
  last_name: Labbé
- first_name: Roberto
  full_name: Maiolino, Roberto
  last_name: Maiolino
- first_name: Rui
  full_name: Marques-Chaves, Rui
  last_name: Marques-Chaves
- first_name: Michael V.
  full_name: Maseda, Michael V.
  last_name: Maseda
- first_name: Charlotte
  full_name: Mason, Charlotte
  last_name: Mason
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Kristen B.W.
  full_name: Mcquinn, Kristen B.W.
  last_name: Mcquinn
- first_name: Georges
  full_name: Meynet, Georges
  last_name: Meynet
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Pascal A.
  full_name: Oesch, Pascal A.
  last_name: Oesch
- first_name: Laura
  full_name: Pentericci, Laura
  last_name: Pentericci
- first_name: Pablo G.
  full_name: Pérez-González, Pablo G.
  last_name: Pérez-González
- first_name: Jane R.
  full_name: Rigby, Jane R.
  last_name: Rigby
- first_name: Guido
  full_name: Roberts-Borsani, Guido
  last_name: Roberts-Borsani
- first_name: Daniel
  full_name: Schaerer, Daniel
  last_name: Schaerer
- first_name: Alice E.
  full_name: Shapley, Alice E.
  last_name: Shapley
- first_name: Daniel P.
  full_name: Stark, Daniel P.
  last_name: Stark
- first_name: Massimo
  full_name: Stiavelli, Massimo
  last_name: Stiavelli
- first_name: Allison L.
  full_name: Strom, Allison L.
  last_name: Strom
- first_name: Eros
  full_name: Vanzella, Eros
  last_name: Vanzella
- first_name: Feige
  full_name: Wang, Feige
  last_name: Wang
- first_name: Stephen M.
  full_name: Wilkins, Stephen M.
  last_name: Wilkins
- first_name: Christina C.
  full_name: Williams, Christina C.
  last_name: Williams
- first_name: Chris J.
  full_name: Willott, Chris J.
  last_name: Willott
- first_name: Dominika
  full_name: Wylezalek, Dominika
  last_name: Wylezalek
- first_name: Antonella
  full_name: Nota, Antonella
  last_name: Nota
citation:
  ama: Adamo A, Atek H, Bagley MB, et al. The first billion years according to JWST.
    <i>Nature Astronomy</i>. 2025;9(8):1134-1147. doi:<a href="https://doi.org/10.1038/s41550-025-02624-5">10.1038/s41550-025-02624-5</a>
  apa: Adamo, A., Atek, H., Bagley, M. B., Bañados, E., Barrow, K. S. S., Berg, D.
    A., … Nota, A. (2025). The first billion years according to JWST. <i>Nature Astronomy</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41550-025-02624-5">https://doi.org/10.1038/s41550-025-02624-5</a>
  chicago: Adamo, Angela, Hakim Atek, Micaela B. Bagley, Eduardo Bañados, Kirk S.S.
    Barrow, Danielle A. Berg, Rachel Bezanson, et al. “The First Billion Years According
    to JWST.” <i>Nature Astronomy</i>. Springer Nature, 2025. <a href="https://doi.org/10.1038/s41550-025-02624-5">https://doi.org/10.1038/s41550-025-02624-5</a>.
  ieee: A. Adamo <i>et al.</i>, “The first billion years according to JWST,” <i>Nature
    Astronomy</i>, vol. 9, no. 8. Springer Nature, pp. 1134–1147, 2025.
  ista: Adamo A, Atek H, Bagley MB, Bañados E, Barrow KSS, Berg DA, Bezanson R, Bradač
    M, Brammer G, Carnall AC, Chisholm J, Coe D, Dayal P, Eisenstein DJ, Eldridge
    JJ, Ferrara A, Fujimoto S, Graaff AD, Habouzit M, Hutchison TA, Kartaltepe JS,
    Kassin SA, Kriek M, Labbé I, Maiolino R, Marques-Chaves R, Maseda MV, Mason C,
    Matthee JJ, Mcquinn KBW, Meynet G, Naidu RP, Oesch PA, Pentericci L, Pérez-González
    PG, Rigby JR, Roberts-Borsani G, Schaerer D, Shapley AE, Stark DP, Stiavelli M,
    Strom AL, Vanzella E, Wang F, Wilkins SM, Williams CC, Willott CJ, Wylezalek D,
    Nota A. 2025. The first billion years according to JWST. Nature Astronomy. 9(8),
    1134–1147.
  mla: Adamo, Angela, et al. “The First Billion Years According to JWST.” <i>Nature
    Astronomy</i>, vol. 9, no. 8, Springer Nature, 2025, pp. 1134–47, doi:<a href="https://doi.org/10.1038/s41550-025-02624-5">10.1038/s41550-025-02624-5</a>.
  short: A. Adamo, H. Atek, M.B. Bagley, E. Bañados, K.S.S. Barrow, D.A. Berg, R.
    Bezanson, M. Bradač, G. Brammer, A.C. Carnall, J. Chisholm, D. Coe, P. Dayal,
    D.J. Eisenstein, J.J. Eldridge, A. Ferrara, S. Fujimoto, A.D. Graaff, M. Habouzit,
    T.A. Hutchison, J.S. Kartaltepe, S.A. Kassin, M. Kriek, I. Labbé, R. Maiolino,
    R. Marques-Chaves, M.V. Maseda, C. Mason, J.J. Matthee, K.B.W. Mcquinn, G. Meynet,
    R.P. Naidu, P.A. Oesch, L. Pentericci, P.G. Pérez-González, J.R. Rigby, G. Roberts-Borsani,
    D. Schaerer, A.E. Shapley, D.P. Stark, M. Stiavelli, A.L. Strom, E. Vanzella,
    F. Wang, S.M. Wilkins, C.C. Williams, C.J. Willott, D. Wylezalek, A. Nota, Nature
    Astronomy 9 (2025) 1134–1147.
date_created: 2025-08-31T22:01:32Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-09-30T14:28:42Z
day: '01'
department:
- _id: JoMa
doi: 10.1038/s41550-025-02624-5
external_id:
  arxiv:
  - '2405.21054'
  isi:
  - '001547681400001'
intvolume: '         9'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2405.21054
month: '08'
oa: 1
oa_version: Preprint
page: 1134-1147
publication: Nature Astronomy
publication_identifier:
  eissn:
  - 2397-3366
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The first billion years according to JWST
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '20256'
abstract:
- lang: eng
  text: We study the problem of predictive runtime monitoring of black-box dynamical
    systems with quantitative safety properties. The black-box setting stipulates
    that the exact semantics of the dynamical system and the controller are unknown,
    and that we are only able to observe the state of the controlled (aka, closed-loop)
    system at finitely many time points. We present a novel framework for predicting
    future states of the system based on the states observed in the past. The numbers
    of past states and of predicted future states are parameters provided by the user.
    Our method is based on a combination of Taylor’s expansion and the backward difference
    operator for numerical differentiation. We also derive an upper bound on the prediction
    error under the assumption that the system dynamics and the controller are smooth.
    The predicted states are then used to predict safety violations ahead in time.
    Our experiments demonstrate practical applicability of our method for complex
    black-box systems, showing that it is computationally lightweight and yet significantly
    more accurate than the state-of-the-art predictive safety monitoring techniques.
acknowledgement: "This work was supported in part by the ERC project ERC-2020-AdG
  101020093.\r\n"
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Fabian
  full_name: Kresse, Fabian
  id: faff3c84-23f6-11ef-9085-e5187b51c604
  last_name: Kresse
- first_name: Kaushik
  full_name: Mallik, Kaushik
  id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598
  last_name: Mallik
  orcid: 0000-0001-9864-7475
- first_name: Zhengqi
  full_name: Yu, Zhengqi
  id: 20aa2ae8-f2f1-11ed-bbfa-8205053f1342
  last_name: Yu
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: 'Henzinger TA, Kresse F, Mallik K, Yu E, Zikelic D. Predictive monitoring of
    black-box dynamical systems. In: <i>7th Annual Learning for Dynamics &#38; Control
    Conference</i>. Vol 283. ML Research Press; 2025:804-816.'
  apa: 'Henzinger, T. A., Kresse, F., Mallik, K., Yu, E., &#38; Zikelic, D. (2025).
    Predictive monitoring of black-box dynamical systems. In <i>7th Annual Learning
    for Dynamics &#38; Control Conference</i> (Vol. 283, pp. 804–816). Ann Arbor,
    MI, United States: ML Research Press.'
  chicago: Henzinger, Thomas A, Fabian Kresse, Kaushik Mallik, Emily Yu, and Dorde
    Zikelic. “Predictive Monitoring of Black-Box Dynamical Systems.” In <i>7th Annual
    Learning for Dynamics &#38; Control Conference</i>, 283:804–16. ML Research Press,
    2025.
  ieee: T. A. Henzinger, F. Kresse, K. Mallik, E. Yu, and D. Zikelic, “Predictive
    monitoring of black-box dynamical systems,” in <i>7th Annual Learning for Dynamics
    &#38; Control Conference</i>, Ann Arbor, MI, United States, 2025, vol. 283, pp.
    804–816.
  ista: 'Henzinger TA, Kresse F, Mallik K, Yu E, Zikelic D. 2025. Predictive monitoring
    of black-box dynamical systems. 7th Annual Learning for Dynamics &#38; Control
    Conference. L4DC: Learning for Dynamics &#38; Control, PMLR, vol. 283, 804–816.'
  mla: Henzinger, Thomas A., et al. “Predictive Monitoring of Black-Box Dynamical
    Systems.” <i>7th Annual Learning for Dynamics &#38; Control Conference</i>, vol.
    283, ML Research Press, 2025, pp. 804–16.
  short: T.A. Henzinger, F. Kresse, K. Mallik, E. Yu, D. Zikelic, in:, 7th Annual
    Learning for Dynamics &#38; Control Conference, ML Research Press, 2025, pp. 804–816.
conference:
  end_date: 2025-06-06
  location: Ann Arbor, MI, United States
  name: 'L4DC: Learning for Dynamics & Control'
  start_date: 2025-06-04
corr_author: '1'
date_created: 2025-08-31T22:01:32Z
date_published: 2025-06-01T00:00:00Z
date_updated: 2025-09-03T10:37:59Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
- _id: ChLa
ec_funded: 1
external_id:
  arxiv:
  - '2412.16564'
file:
- access_level: open_access
  checksum: d5236e561560635f5ae1d17de4903033
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-03T10:32:12Z
  date_updated: 2025-09-03T10:32:12Z
  file_id: '20283'
  file_name: 2025_L4DC_HenzingerT.pdf
  file_size: 489639
  relation: main_file
  success: 1
file_date_updated: 2025-09-03T10:32:12Z
has_accepted_license: '1'
intvolume: '       283'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 804-816
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: 7th Annual Learning for Dynamics & Control Conference
publication_identifier:
  eissn:
  - 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Predictive monitoring of black-box dynamical systems
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 283
year: '2025'
...
---
OA_type: closed access
_id: '20259'
abstract:
- lang: eng
  text: Cell migration in narrow microenvironments occurs in numerous physiological
    processes. It involves successive cycles of confinement and release that drive
    important morphological changes. However, it remains unclear whether migrating
    cells can retain a memory of their past morphological states that could potentially
    facilitate their navigation through confined spaces. We demonstrate that local
    geometry governs a switch between two cell morphologies, thereby facilitating
    cell passage through long and narrow gaps. We combined cell migration assays on
    standardized microsystems with biophysical modelling and biochemical perturbations
    to show that migrating cells have a long-term memory of past confinement events.
    The morphological cell states correlate across transitions through actin cortex
    remodelling. These findings indicate that mechanical memory in migrating cells
    plays an active role in their migratory potential in confined environments.
acknowledgement: We are grateful to members of S.G.’s laboratory for feedback and
  suggestions. We thank E. Hannezo, J. O. Rädler, M. Piel, O. du Roure and J. Heuvingh
  for inspiring discussions. Y.K. and S.G. acknowledge J. B. Braquenier from Nikon
  Instruments Belux and the Nikon BioImaging Lab in Leiden (the Netherlands) for their
  support with the Nikon Spatial Array Confocal enhanced-resolution confocal microscopy.
  We thank D. S. Herrador and M. Balland for their help in improving the microprinting
  method. D.B.B. was supported by the NOMIS Foundation as a NOMIS Fellow and by an
  EMBO Postdoctoral Fellowship (ALTF 343-2022). Y.K., M.L. and S.G. acknowledge funding
  from the University of Mons (FEDER Prostem Research Project no. 1510614, Wallonia
  DG06), the F.R.S.-FNRS (Epiforce Project no. T.0092.21, Cellsqueezer Project no.
  J.0061.23 and Optopattern Project no. U.NO26.22) and the Interreg projects ANTIRESI
  and MICROPLAITE, which are financially supported by Interreg France-Wallonie-Vlaanderen
  (Fonds Européen de Développement Régional). Y.K. and M.L. are financially supported
  by F.R.S.-FNRS as FRIA Grantee FNRS and Postdoctoral Fellow (Chargé de Recherches),
  respectively. Y.K. and S.G. acknowledge le Fonds pour la Recherche Médicale dans
  le Hainaut (FRMH). G.C. was supported by a grant from the Biotechnology and Biological
  Sciences Research Council (grant no. BB/V007483/1).
article_processing_charge: No
article_type: original
author:
- first_name: Yohalie
  full_name: Kalukula, Yohalie
  last_name: Kalukula
- first_name: Marine
  full_name: Luciano, Marine
  last_name: Luciano
- first_name: Gleb
  full_name: Simanov, Gleb
  last_name: Simanov
- first_name: Guillaume
  full_name: Charras, Guillaume
  last_name: Charras
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Sylvain
  full_name: Gabriele, Sylvain
  last_name: Gabriele
citation:
  ama: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. The actin
    cortex acts as a mechanical memory of morphology in confined migrating cells.
    <i>Nature Physics</i>. 2025;21:1451-1461. doi:<a href="https://doi.org/10.1038/s41567-025-02980-z">10.1038/s41567-025-02980-z</a>
  apa: Kalukula, Y., Luciano, M., Simanov, G., Charras, G., Brückner, D., &#38; Gabriele,
    S. (2025). The actin cortex acts as a mechanical memory of morphology in confined
    migrating cells. <i>Nature Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-025-02980-z">https://doi.org/10.1038/s41567-025-02980-z</a>
  chicago: Kalukula, Yohalie, Marine Luciano, Gleb Simanov, Guillaume Charras, David
    Brückner, and Sylvain Gabriele. “The Actin Cortex Acts as a Mechanical Memory
    of Morphology in Confined Migrating Cells.” <i>Nature Physics</i>. Springer Nature,
    2025. <a href="https://doi.org/10.1038/s41567-025-02980-z">https://doi.org/10.1038/s41567-025-02980-z</a>.
  ieee: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, and S. Gabriele,
    “The actin cortex acts as a mechanical memory of morphology in confined migrating
    cells,” <i>Nature Physics</i>, vol. 21. Springer Nature, pp. 1451–1461, 2025.
  ista: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. 2025.
    The actin cortex acts as a mechanical memory of morphology in confined migrating
    cells. Nature Physics. 21, 1451–1461.
  mla: Kalukula, Yohalie, et al. “The Actin Cortex Acts as a Mechanical Memory of
    Morphology in Confined Migrating Cells.” <i>Nature Physics</i>, vol. 21, Springer
    Nature, 2025, pp. 1451–61, doi:<a href="https://doi.org/10.1038/s41567-025-02980-z">10.1038/s41567-025-02980-z</a>.
  short: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, S. Gabriele,
    Nature Physics 21 (2025) 1451–1461.
corr_author: '1'
date_created: 2025-08-31T22:01:33Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2025-12-30T09:34:11Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-025-02980-z
external_id:
  isi:
  - '001556019400001'
intvolume: '        21'
isi: 1
language:
- iso: eng
month: '09'
oa_version: None
page: 1451-1461
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
  grant_number: ALTF 343-2022
  name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The actin cortex acts as a mechanical memory of morphology in confined migrating
  cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20260'
abstract:
- lang: eng
  text: The medial axis of a set consists of the points in the ambient space without
    a unique closest point in the original set. Since its introduction, the medial
    axis has been used extensively in many applications as a method of computing a
    skeleton topologically equivalent to the original set. Unfortunately, one limiting
    factor in the use of the medial axis of a smooth manifold is that it is not necessarily
    topologically stable under small perturbations of the manifold. To counter these
    instabilities, various prunings of the medial axis have been proposed in the computational
    geometry community. Here, we examine one type of pruning, called burning. Because
    of the good experimental results it was hoped that the burning method of simplifying
    the medial axis would be stable. In this work, we show a simple example that dashes
    such hopes. Based on Bing’s house with two rooms, we demonstrate an isotopy of
    a shape where the medial axis goes from collapsible to non-collapsible. More precisely,
    we consider the standard deformation retract from the closed ball to Bing’s house
    with two rooms, but stop just short of the point where Bing’s house becomes two
    dimensional. This way we obtain an isotopy from the 3-ball to a thickened version
    of Bing’s house. Under this isotopy, the medial axis goes from collapsible to
    non-collapsible. We stress that this isotopy can be made generic, in the sense
    of singularity theory, as developed by Arnol’d and Thom.
acknowledgement: "We thank André Lieutier, David Letscher, Ellen Gasparovic, Kathryn
  Leonard, and Tao Ju for early discussions on this work. We also thank Lu Liu, Yajie
  Yan, and Tao Ju for sharing code to generate the examples. We further thank Abigail
  Thompson for discussion on the conjecture and James Damon for sharing his insight
  in singularity theory. We thank the reviewers for their detailed reviews, which
  helped to improve the exposition.\r\nOpen access funding provided by Institute of
  Science and Technology (IST Austria). Partially supported by the DFG Collaborative
  Research Center TRR 109, ‘Discretization in Geometry and Dynamics’ and the European
  Research Council (ERC), grant no. 788183, ‘Alpha Shape Theory Extended’. The first
  author was supported in part by the National Science Foundation through grants DBI-1759807,
  CCF-1907612, and CCF-2444309. The fourth author was supported by the European Union’s
  Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  grant agreement No. 754411, the Austrian science fund (FWF) M-3073, ANR grant StratMesh,
  ANR-24-CE48-1899, and the welcome package from IDEX of the Université Côte d’Azur,
  ANR-15-IDEX-01."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Erin Wolf
  full_name: Chambers, Erin Wolf
  last_name: Chambers
- first_name: Christopher D
  full_name: Fillmore, Christopher D
  id: 35638A5C-AAC7-11E9-B0BF-5503E6697425
  last_name: Fillmore
- first_name: Elizabeth R
  full_name: Stephenson, Elizabeth R
  id: 2D04F932-F248-11E8-B48F-1D18A9856A87
  last_name: Stephenson
  orcid: 0000-0002-6862-208X
- first_name: Mathijs
  full_name: Wintraecken, Mathijs
  id: 307CFBC8-F248-11E8-B48F-1D18A9856A87
  last_name: Wintraecken
  orcid: 0000-0002-7472-2220
citation:
  ama: Chambers EW, Fillmore CD, Stephenson ER, Wintraecken M. Burning or collapsing
    the medial axis is unstable. <i>La Matematica</i>. 2025;4:811-828. doi:<a href="https://doi.org/10.1007/s44007-025-00170-0">10.1007/s44007-025-00170-0</a>
  apa: Chambers, E. W., Fillmore, C. D., Stephenson, E. R., &#38; Wintraecken, M.
    (2025). Burning or collapsing the medial axis is unstable. <i>La Matematica</i>.
    Springer Nature. <a href="https://doi.org/10.1007/s44007-025-00170-0">https://doi.org/10.1007/s44007-025-00170-0</a>
  chicago: Chambers, Erin Wolf, Christopher D Fillmore, Elizabeth R Stephenson, and
    Mathijs Wintraecken. “Burning or Collapsing the Medial Axis Is Unstable.” <i>La
    Matematica</i>. Springer Nature, 2025. <a href="https://doi.org/10.1007/s44007-025-00170-0">https://doi.org/10.1007/s44007-025-00170-0</a>.
  ieee: E. W. Chambers, C. D. Fillmore, E. R. Stephenson, and M. Wintraecken, “Burning
    or collapsing the medial axis is unstable,” <i>La Matematica</i>, vol. 4. Springer
    Nature, pp. 811–828, 2025.
  ista: Chambers EW, Fillmore CD, Stephenson ER, Wintraecken M. 2025. Burning or collapsing
    the medial axis is unstable. La Matematica. 4, 811–828.
  mla: Chambers, Erin Wolf, et al. “Burning or Collapsing the Medial Axis Is Unstable.”
    <i>La Matematica</i>, vol. 4, Springer Nature, 2025, pp. 811–28, doi:<a href="https://doi.org/10.1007/s44007-025-00170-0">10.1007/s44007-025-00170-0</a>.
  short: E.W. Chambers, C.D. Fillmore, E.R. Stephenson, M. Wintraecken, La Matematica
    4 (2025) 811–828.
corr_author: '1'
date_created: 2025-08-31T22:01:33Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2026-04-07T11:42:48Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s44007-025-00170-0
ec_funded: 1
file:
- access_level: open_access
  checksum: e2043259194bfcdf3d74c4da8a5a853f
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  date_created: 2025-12-30T07:52:58Z
  date_updated: 2025-12-30T07:52:58Z
  file_id: '20885'
  file_name: 2025_LaMatematica_Chambers.pdf
  file_size: 2678640
  relation: main_file
  success: 1
file_date_updated: 2025-12-30T07:52:58Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 811-828
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '788183'
  name: Alpha Shape Theory Extended
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: fc390959-9c52-11eb-aca3-afa58bd282b2
  grant_number: M03073
  name: Learning and triangulating manifolds via collapses
publication: La Matematica
publication_identifier:
  eissn:
  - 2730-9657
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '21021'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Burning or collapsing the medial axis is unstable
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2025'
...
---
APC_amount: 5766,07 EUR
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20289'
abstract:
- lang: eng
  text: Cell and tissue movement in development, cancer invasion, and immune response
    relies on chemical or mechanical guidance cues. In many systems, this behavior
    is locally directed by self-generated signaling gradients rather than long-range,
    prepatterned cues. However, how heterogeneous mixtures of cells interact nonreciprocally
    and navigate through self-generated gradients remains largely unexplored. Here,
    we introduce a theoretical framework for the self-organized chemotaxis of heterogeneous
    cell populations. We find that the relative chemotactic sensitivities of different
    cell populations control their long-time coupling and comigration dynamics, with
    boundary conditions such as external cell and attractant reservoirs substantially
    influencing the migration patterns. Our model predicts an optimal parameter regime
    that enables robust and colocalized migration. We test our theoretical predictions
    with in vitro experiments demonstrating the comigration of distinct immune cell
    populations, and quantitatively reproduce observed migration patterns under wild-type
    and perturbed conditions. Interestingly, immune cell comigration occurs close
    to the predicted optimal regime. Finally, we incorporate mechanical interactions
    into our framework, revealing a nontrivial interplay between chemotactic and mechanical
    nonreciprocity in driving collective migration. Together, our findings suggest
    that self-generated chemotaxis is a robust strategy for the navigation of mixed
    cell populations.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: NanoFab
acknowledgement: We thank all members of the M.S. and E.H. groups for stimulating
  discussions.We thank the Imaging and Optics facility, the Pre-clinical and Lab Support
  facility of the Institute of Science and Technology Austria for their excellent
  support and provided resources for the experimental research. In particular, we
  thank Jack Merrin from the Nanofabrication facility who generated the microfabricated
  channel used in this study. This work received funding fromt he European Research
  Council under the European Union’s Horizon 2020 research and innovation program
  (grant agreement No. 851288 to E.H.). M.C.U.is funded by a University of Shefﬁeld
  Strategic Research Fellowship in the Physics of Life and Quantitative Biology.
article_number: e2504064122
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Mehmet C
  full_name: Ucar, Mehmet C
  id: 50B2A802-6007-11E9-A42B-EB23E6697425
  last_name: Ucar
  orcid: 0000-0003-0506-4217
- first_name: Alsberga
  full_name: Zane, Alsberga
  id: 60f7509a-f652-11ea-9d86-b963d6490d7c
  last_name: Zane
  orcid: 0009-0003-0415-7603
- first_name: Jonna H
  full_name: Alanko, Jonna H
  id: 2CC12E8C-F248-11E8-B48F-1D18A9856A87
  last_name: Alanko
  orcid: 0000-0002-7698-3061
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
citation:
  ama: Ucar MC, Zane A, Alanko JH, Sixt MK, Hannezo EB. Self-generated chemotaxis
    of mixed cell populations. <i>Proceedings of the National Academy of Sciences</i>.
    2025;122(34). doi:<a href="https://doi.org/10.1073/pnas.2504064122">10.1073/pnas.2504064122</a>
  apa: Ucar, M. C., Zane, A., Alanko, J. H., Sixt, M. K., &#38; Hannezo, E. B. (2025).
    Self-generated chemotaxis of mixed cell populations. <i>Proceedings of the National
    Academy of Sciences</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2504064122">https://doi.org/10.1073/pnas.2504064122</a>
  chicago: Ucar, Mehmet C, Alsberga Zane, Jonna H Alanko, Michael K Sixt, and Edouard
    B Hannezo. “Self-Generated Chemotaxis of Mixed Cell Populations.” <i>Proceedings
    of the National Academy of Sciences</i>. National Academy of Sciences, 2025. <a
    href="https://doi.org/10.1073/pnas.2504064122">https://doi.org/10.1073/pnas.2504064122</a>.
  ieee: M. C. Ucar, A. Zane, J. H. Alanko, M. K. Sixt, and E. B. Hannezo, “Self-generated
    chemotaxis of mixed cell populations,” <i>Proceedings of the National Academy
    of Sciences</i>, vol. 122, no. 34. National Academy of Sciences, 2025.
  ista: Ucar MC, Zane A, Alanko JH, Sixt MK, Hannezo EB. 2025. Self-generated chemotaxis
    of mixed cell populations. Proceedings of the National Academy of Sciences. 122(34),
    e2504064122.
  mla: Ucar, Mehmet C., et al. “Self-Generated Chemotaxis of Mixed Cell Populations.”
    <i>Proceedings of the National Academy of Sciences</i>, vol. 122, no. 34, e2504064122,
    National Academy of Sciences, 2025, doi:<a href="https://doi.org/10.1073/pnas.2504064122">10.1073/pnas.2504064122</a>.
  short: M.C. Ucar, A. Zane, J.H. Alanko, M.K. Sixt, E.B. Hannezo, Proceedings of
    the National Academy of Sciences 122 (2025).
corr_author: '1'
date_created: 2025-09-07T22:01:32Z
date_published: 2025-08-26T00:00:00Z
date_updated: 2026-05-20T08:59:54Z
day: '26'
ddc:
- '570'
department:
- _id: EdHa
- _id: MiSi
doi: 10.1073/pnas.2504064122
ec_funded: 1
external_id:
  isi:
  - '001562181600001'
  pmid:
  - '40838890'
file:
- access_level: open_access
  checksum: b36abd92673b6d76376fc9434bad52cc
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-08T07:23:29Z
  date_updated: 2025-09-08T07:23:29Z
  file_id: '20307'
  file_name: 2025_PNAS_Ucar.pdf
  file_size: 16069140
  relation: main_file
  success: 1
file_date_updated: 2025-09-08T07:23:29Z
has_accepted_license: '1'
intvolume: '       122'
isi: 1
issue: '34'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/mehmetcanucar/Self-generated-chemotaxis
scopus_import: '1'
status: public
title: Self-generated chemotaxis of mixed cell populations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 122
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '20290'
abstract:
- lang: eng
  text: 'We consider equilibria in multiplayer stochastic graph games with terminal-node
    rewards. In such games, Nash equilibria are defined assuming that each player
    seeks to maximise their expected payoff, ignoring their aversion or tolerance
    to risk. We therefore study risk-sensitive equilibria (RSEs), where the expected
    payoff is replaced by a risk measure. A classical risk measure in the literature
    is the entropic risk measure, where each player has a real valued parameter capturing
    their risk-averseness. We introduce the extreme risk measure, which corresponds
    to extreme cases of entropic risk measure, where players are either extreme optimists
    or extreme pessimists. Under extreme risk measure, every player is an extremist:
    an extreme optimist perceives their reward as the maximum payoff that can be achieved
    with positive probability, while an extreme pessimist expects the minimum payoff
    achievable with positive probability. We argue that the extreme risk measure,
    especially in multi-player graph based settings, is particularly relevant as they
    can model several real life instances such as interactions between secure systems
    and potential security threats, or distributed controls for safety critical systems.
    We prove that RSEs defined with the extreme risk measure are guaranteed to exist
    when all rewards are non-negative. Furthermore, we prove that the problem of deciding
    whether a given game contains an RSE that generates risk measures within specified
    intervals is decidable and NP-complete for our extreme risk measure, and even
    PTIME-complete when all players are extreme optimists, while that same problem
    is undecidable using the entropic risk measure or even the classical expected
    payoff. This establishes, to our knowledge, the first decidable fragment for equilibria
    in simple stochastic games without restrictions on strategy types or number of
    players.'
acknowledgement: "This work is a part of project VAMOS that has received funding from
  the European\r\nResearch Council (ERC), grant agreement No 101020093. We thank anonymous
  reviewers for pointing us to the Hurwicz criterion and to the work of Gallego-Hernández
  and Mansutti [13]. We thank Marie van den Bogaard for her valuable feedback on the
  first author’s PhD dissertation, which helped improve the quality of this work. "
alternative_title:
- LIPIcs
article_number: '30'
article_processing_charge: Yes
arxiv: 1
author:
- first_name: Léonard
  full_name: Brice, Léonard
  last_name: Brice
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: K. S.
  full_name: Thejaswini, K. S.
  id: 3807fb92-fdc1-11ee-bb4a-b4d8a431c753
  last_name: Thejaswini
citation:
  ama: 'Brice L, Henzinger TA, Thejaswini KS. Finding equilibria: Simpler for pessimists,
    simplest for optimists. In: <i>50th International Symposium on Mathematical Foundations
    of Computer Science</i>. Vol 345. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2025. doi:<a href="https://doi.org/10.4230/LIPIcs.MFCS.2025.30">10.4230/LIPIcs.MFCS.2025.30</a>'
  apa: 'Brice, L., Henzinger, T. A., &#38; Thejaswini, K. S. (2025). Finding equilibria:
    Simpler for pessimists, simplest for optimists. In <i>50th International Symposium
    on Mathematical Foundations of Computer Science</i> (Vol. 345). Warsaw, Poland:
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.MFCS.2025.30">https://doi.org/10.4230/LIPIcs.MFCS.2025.30</a>'
  chicago: 'Brice, Léonard, Thomas A Henzinger, and K. S. Thejaswini. “Finding Equilibria:
    Simpler for Pessimists, Simplest for Optimists.” In <i>50th International Symposium
    on Mathematical Foundations of Computer Science</i>, Vol. 345. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2025. <a href="https://doi.org/10.4230/LIPIcs.MFCS.2025.30">https://doi.org/10.4230/LIPIcs.MFCS.2025.30</a>.'
  ieee: 'L. Brice, T. A. Henzinger, and K. S. Thejaswini, “Finding equilibria: Simpler
    for pessimists, simplest for optimists,” in <i>50th International Symposium on
    Mathematical Foundations of Computer Science</i>, Warsaw, Poland, 2025, vol. 345.'
  ista: 'Brice L, Henzinger TA, Thejaswini KS. 2025. Finding equilibria: Simpler for
    pessimists, simplest for optimists. 50th International Symposium on Mathematical
    Foundations of Computer Science. MFCS: Mathematical Foundations of Computer Science,
    LIPIcs, vol. 345, 30.'
  mla: 'Brice, Léonard, et al. “Finding Equilibria: Simpler for Pessimists, Simplest
    for Optimists.” <i>50th International Symposium on Mathematical Foundations of
    Computer Science</i>, vol. 345, 30, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2025, doi:<a href="https://doi.org/10.4230/LIPIcs.MFCS.2025.30">10.4230/LIPIcs.MFCS.2025.30</a>.'
  short: L. Brice, T.A. Henzinger, K.S. Thejaswini, in:, 50th International Symposium
    on Mathematical Foundations of Computer Science, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2025.
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title: 'Finding equilibria: Simpler for pessimists, simplest for optimists'
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