Cheung, G. T., Pauler, F., Koppensteiner, P., Krausgruber, T., Streicher, C., Schrammel, M.,https://doi.org/10.1016/j.neuron.2023.11.009__Hippenmeyer, S. (2024). Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2023.11.009 

Koppensteiner, P., Bhandari, P., Önal, C., Borges Merjane, C., Le Monnier, E., Roy, U.,https://doi.org/10.1073/pnas.2301449121__Shigemoto, R. (2024). GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences.https://doi.org/10.1073/pnas.2301449121 

Chen, J., Kaufmann, W., Chen, C., Arai,https://doi.org/10.1016/j.neuron.2023.12.002__itaru, Kim, O., Shigemoto, R., &; Jonas, P. M. (n.d.). Developmental transformation of C+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2023.12.002 

Vierra, N. C., Ribeiro-Silva, L., Kirmiz, M., Van Der List, D., Bhandari, P., Mack, O. A.,https://doi.org/10.1038/s41467-023-40930-6__Trimmer, J. S. (2023). Neuronal ER-plasma membrane junctions couple excitation to C+-activated PKA signaling. Nature Communications. Springer Nature.https://doi.org/10.1038/s41467-023-40930-6 

Eguchi, K., Le Monnier, E., &; Shigemoto, R. (2023). Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons. The Journal of Neuroscience. Society for Neuroscience.https://doi.org/10.1523/JNEUROSCI.1514-22.2023 

Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A.,https://doi.org/10.1038/s41587-023-01911-8__Danzl, J. G. (2023). Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. Springer Nature.https://doi.org/10.1038/s41587-023-01911-8 

Alcarva, C. (2023). Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning. Institute of Science and Technology Austria.https://doi.org/10.15479/at:ista:12809 

Eguchi, K., Montanaro-Punzengruber, J.-C., Le Monnier, E., &; Shigemoto, R. (2022). The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals. Frontiers in Neuroanatomy. Frontiers.https://doi.org/10.3389/fnana.2022.846615 

Shigemoto, R. (2022). Electron microscopic visualization of single molecules by tag-mediated metal particle labeling. Microscopy. Oxford Academic.https://doi.org/10.1093/jmicro/dfab048 

Hori, T., Eguchi, K., Wang, H. Y., Miyasaka, T., Guillaud, L., Taoufiq, Z.,https://doi.org/10.7554/eLife.73542__Takahashi, T. (2022). Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model. ELife. eLife Sciences Publications.https://doi.org/10.7554/eLife.73542 

Martín-Belmonte, A., Aguado, C., Alfaro-Ruiz, R., Moreno-Martínez, A. E., de la Ossa, L., Aso, E.,https://doi.org/10.1186/s13195-022-01078-5__Luján, R. (2022). Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/P mice. Alzheimer’s Research &; Therapy. Springer Nature.https://doi.org/10.1186/s13195-022-01078-5 

Thayyil, S., Nishigami, Y., Islam, M. J., Hashim, P. K., Furuta, K., Oiwa, K.,https://doi.org/10.1002/chem.202200807__Tamaoki, N. (2022). Dynamic control of microbial movement by photoswitchable ATP antagonists. Chemistry - A European Journal. Wiley.https://doi.org/10.1002/chem.202200807 

Jevtic, M. (2022). Contextual fear learning induced changes in AMPA receptor subtypes along the proximodistal axis in dorsal hippocampus. Institute of Science and Technology Austria.https://doi.org/10.15479/at:ista:11393 

Fredes Tolorza, F. A., Silva Sifuentes, M. A., Koppensteiner, P., Kobayashi, K., Jösch, M. A., &; Shigemoto, R. (2021). Ventro-dorsal hippocampal pathway gates novelty-induced contextual memory formation. Current Biology. Elsevier.https://doi.org/10.1016/j.cub.2020.09.074 

Schöpf, C. L., Ablinger, C., Geisler, S. M., Stanika, R. I., Campiglio, M., Kaufmann, W.,https://doi.org/10.1073/pnas.1920827118__Obermair, G. J. (2021). Presynaptic ;12;4 subunits are key organizers of glutamatergic synapses. PNAS. National Academy of Sciences.https://doi.org/10.1073/pnas.1920827118 

Fredes, F., &; Shigemoto, R. (2021). The role of hippocampal mossy cells in novelty detection. Neurobiology of Learning and Memory. Elsevier.https://doi.org/10.1016/j.nlm.2021.107486 

Butola, T., Alvanos, T., Hintze, A., Koppensteiner, P., Kleindienst, D., Shigemoto, R.,https://doi.org/10.1523/JNEUROSCI.0586-21.2021__Moser, T. (2021). RIM-binding protein 2 organizes Ca<sup>21</sup> channel topography and regulates release probability and vesicle replenishment at a fast central synapse. Journal of Neuroscience. Society for Neuroscience.https://doi.org/10.1523/JNEUROSCI.0586-21.2021 

Biane, C., Rückerl, F., Abrahamsson, T., Saint-Cloment, C., Mariani, J., Shigemoto, R.,https://doi.org/10.7554/eLife.65954__Cathala, L. (2021). Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. ELife. eLife Sciences Publications.https://doi.org/10.7554/eLife.65954 

Bhandari, P., Vandael, D. H., Fernández-Fernández, D., Fritzius, T., Kleindienst, D., Önal, H. C.,https://doi.org/10.7554/ELIFE.68274__Koppensteiner, P. (2021). GABAB receptor auxiliary subunits modulate Ca.3-mediated release from medial habenula terminals. ELife. eLife Sciences Publications.https://doi.org/10.7554/ELIFE.68274 

Kleindienst, D. (2021). 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning. Institute of Science and Technology Austria.https://doi.org/10.15479/at:ista:9562 

Kaufmann, W., Kleindienst, D., Harada, H., &; Shigemoto, R. (2021). High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In https://doi.org/10.1007/978-1-0716-1522-5_19__Receptor and Ion Channel Detection in the Brain (Vol. 169, pp. 267–283). New York: Humana.https://doi.org/10.1007/978-1-0716-1522-5_19 

Nakamoto, C., Konno, K., Miyazaki, T., Nakatsukasa, E., Natsume, R., Abe, M.,https://doi.org/10.1002/cne.24792__Watanabe, M. (2020). Expression mapping, quantification, and complex formation of Glu and Glu glutamate receptors in adult mouse brain. Journal of Comparative Neurology. Wiley.https://doi.org/10.1002/cne.24792 

Piriya Ananda Babu, L., Wang, H. Y., Eguchi, K., Guillaud, L., &; Takahashi, T. (2020). Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. Journal of Neuroscience. Society for Neuroscience.https://doi.org/10.1523/JNEUROSCI.1571-19.2019 

Martín-Belmonte, A., Aguado, C., Alfaro-Ruíz, R., Moreno-Martínez, A. E., De La Ossa, L., Martínez-Hernández, J.,https://doi.org/10.3390/ijms21072459__Luján, R. (2020). Density of GABAB receptors is reduced in granule cells of the hippocampus in a mouse model of Alzheimer’s disease. International Journal of Molecular Sciences. MDPI.https://doi.org/10.3390/ijms21072459 

Eguchi, K., Velicky, P., Saeckl, E., Itakura, M., Fukazawa, Y., Danzl, J. G., &; Shigemoto, R. (2020). Advantages of acute brain slices prepared at physiological temperature in the characterization of synaptic functions. Frontiers in Cellular Neuroscience. Frontiers Media.https://doi.org/10.3389/fncel.2020.00063 

Bao, J., Graupner, M., Astorga, G., Collin, T., Jalil, A., Indriati, D. W.,https://doi.org/10.7554/eLife.56839__Llano, I. (2020). Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo. ELife. eLife Sciences Publications.https://doi.org/10.7554/eLife.56839 

Wang, H. Y., Eguchi, K., Yamashita, T., &; Takahashi, T. (2020). Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. Journal of Neuroscience. Society for Neuroscience.https://doi.org/10.1523/JNEUROSCI.2946-19.2020 

Martín-Belmonte, A., Aguado, C., Alfaro-Ruíz, R., Moreno-Martínez, A. E., De La Ossa, L., Martínez-Hernández, J.,https://doi.org/10.1111/bpa.12802__Luján, R. (2020). Reduction in the neuronal surface of post and presynaptic GABA&;B&; receptors in the hippocampus in a mouse model of Alzheimer’s disease. Brain Pathology. Wiley.https://doi.org/10.1111/bpa.12802 

Bhandari, P. (2020). Localization and functional role of Ca.3 in the medial habenula to interpeduncular nucleus pathway. Institute of Science and Technology Austria.https://doi.org/10.15479/AT:ISTA:7525 

Kleindienst, D., Montanaro-Punzengruber, J.-C., Bhandari, P., Case, M. J., Fukazawa, Y., &; Shigemoto, R. (2020). Deep learning-assisted high-throughput analysis of freeze-fracture replica images applied to glutamate receptors and calcium channels at hippocampal synapses. International Journal of Molecular Sciences. MDPI.https://doi.org/10.3390/ijms21186737 

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I.,https://doi.org/10.1246/bcsj.20190034__Ojida, A. (2019). Optimized reaction pair of the CysHis tag and Ni(II)-NTA probe for highly selective chemical labeling of membrane proteins. Bulletin of the Chemical Society of Japan. Bulletin of the Chemical Society of Japan.https://doi.org/10.1246/bcsj.20190034 

Byczkowicz, N., Eshra, A., Montanaro-Punzengruber, J.-C., Trevisiol, A., Hirrlinger, J., Kole, M. H.,https://doi.org/10.7554/eLife.42766__Hallermann, S. (2019). HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. ELife. eLife Sciences Publications.https://doi.org/10.7554/eLife.42766 

Kasugai, Y., Vogel, E., Hörtnagl, H., Schönherr, S., Paradiso, E., Hauschild, M.,https://doi.org/10.1016/j.neuron.2019.08.013__Ferraguti, F. (2019). Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2019.08.013 

Klotz, L., Wendler, O., Frischknecht, R., Shigemoto, R., Schulze, H., &; Enz, R. (2019). Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB Journal. FASEB.https://doi.org/10.1096/fj.201901543R 

Erdem, F. A., Ilic, M., Koppensteiner, P., Goacki, J., Lubec, G., Freissmuth, M., &; Sandtner, W. (2019). A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2. The Journal of General Physiology. Rockefeller University Press.https://doi.org/10.1085/jgp.201912318 

Tabata, S., Jevtic, M., Kurashige, N., Fuchida, H., Kido, M., Tani, K.,https://doi.org/10.1016/j.isci.2019.11.025__Ojida, A. (2019). Electron microscopic detection of single membrane proteins by a specific chemical labeling. IScience. Elsevier.https://doi.org/10.1016/j.isci.2019.11.025 

Dimitrov, D., Guillaud, L., Eguchi, K., &; Takahashi, T. (2018). Culture of mouse giant central nervous system synapses and application for imaging and electrophysiological analyses. In S. D. Skaper (Ed.), Neurotrophic Factors (Vol. 1727, pp. 201–215). Springer.https://doi.org/10.1007/978-1-4939-7571-6_15 

Luján, R., Aguado, C., Ciruela, F., Arus, X., Martín Belmonte, A., Alfaro Ruiz, R.,https://doi.org/10.3389/fncel.2018.00311__Fukazawa, Y. (2018). Sk2 channels associate with mGlu1;1 receptors and Ca.1 channels in Purkinje cells. Frontiers in Cellular Neuroscience. Frontiers Media.https://doi.org/10.3389/fncel.2018.00311 

Sawada, K., Kawakami, R., Shigemoto, R., &; Nemoto, T. (2018). Super resolution structural analysis of dendritic spines using three-dimensional structured illumination microscopy in cleared mouse brain slices. European Journal of Neuroscience. Wiley.https://doi.org/10.1111/ejn.13901 

Miklosi, A., Del Favero, G., Bulat, T., Höger, H., Shigemoto, R., Marko, D., &; Lubec, G. (2018). Super resolution microscopical localization of dopamine receptors 1 and 2 in rat hippocampal synaptosomes. Molecular Neurobiology. Springer.https://doi.org/10.1007/s12035-017-0688-y 

Reipert, S., Goldammer, H., Richardson, C., Goldberg, M., Hawkins, T., Saeckl, E.,https://doi.org/10.1369/0022155418786698__Stierhof, Y. (2018). Agitation modules: Flexible means to accelerate automated freeze substitution. Journal of Histochemistry and Cytochemistry. SAGE Publications.https://doi.org/10.1369/0022155418786698 

Case, M. J. (2018). From the left to the right: A tale of asymmetries, environments, and hippocampal development. Institute of Science and Technology Austria.https://doi.org/10.15479/AT:ISTA:th_1032 

Luján, R., Aguado, C., Ciruela, F., Cózar, J., Kleindienst, D., De La Ossa, L.,https://doi.org/10.1007/s00429-017-1568-y__Fukazawa, Y. (2018). Differential association of GABAB receptors with their effector ion channels in Purkinje cells. Brain Structure and Function. Springer.https://doi.org/10.1007/s00429-017-1568-y 

Sun, W., Zhai, M.-Z., Zhou, Q., Qian, C., &; Jiang, C. (2017). Effects of B vitamins overload on plasma insulin level and hydrogen peroxide generation in rats. Chinese Journal of Physiology. Chinese Physiological Society.https://doi.org/10.4077/CJP.2017.BAF469 

Miki, T., Kaufmann, W., Malagon, G., Gomez, L., Tabuchi, K., Watanabe, M.,https://doi.org/10.1073/pnas.1704470114__Marty, A. (2017). Numbers of presynaptic C+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. PNAS. National Academy of Sciences.https://doi.org/10.1073/pnas.1704470114 

Sun, W., Li, C., Zhang, Y., Jiang, C., Zhai, M.-Z., Zhou, Q.,https://doi.org/10.1002/cbin.10783__Deng, Q. (2017). Gene expression changes of thermo sensitive transient receptor potential channels in obese mice. Cell Biology International. Wiley-Blackwell.https://doi.org/10.1002/cbin.10783 

Rubio, M., Matsui, K., Fukazawa, Y., Kamasawa, N., Harada, H., Itakura, M.,https://doi.org/10.1007/s00429-017-1408-0__Shigemoto, R. (2017). The number and distribution of AMPA receptor channels containing fast kinetic Glu and Glu subunits at auditory nerve synapses depend on the target cells. Brain Structure and Function. Springer.https://doi.org/10.1007/s00429-017-1408-0 

Shigemoto, R., &; Jösch, M. A. (2017). The genetic encoded toolbox for electron microscopy and connectomics. WIREs Developmental Biology. Wiley-Blackwell.https://doi.org/10.1002/wdev.288 

Aloisi, E., Le Corf, K., Dupuis, J., Zhang, P., Ginger, M., Labrousse, V.,https://doi.org/10.1038/s41467-017-01191-2__Frick, A. (2017). Altered surface mGlu dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. Nature Publishing Group.https://doi.org/10.1038/s41467-017-01191-2 

Sun, W., Zhai, M.-Z., Li, D., Zhou, Y., Chen, N., Guo, M., &; Zhou, S. (2017). Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clinical Nutrition. Elsevier.https://doi.org/10.1016/j.clnu.2016.07.016 

Jiang, C., Zhai, M.-Z., Yan, D., Li, D., Li, C., Zhang, Y.,https://doi.org/10.18632/oncotarget.20540__Sun, W. (2017). Dietary menthol-induced TRPM8 activation enhances WAT wning”https://doi.org/10.18632/oncotarget.20540__and ameliorates diet-induced obesity. Oncotarget. Impact Journals.https://doi.org/10.18632/oncotarget.20540 

Ukai, H., Kawahara, A., Hirayama, K., Case, M. J., Aino, S., Miyabe, M.,https://doi.org/10.1371/journal.pone.0179377__Ito, I. (2017). PirB regulates asymmetries in hippocampal circuitry. PLoS One. Public Library of Science.https://doi.org/10.1371/journal.pone.0179377 

Booker, S., Althof, D., Gross, A., Loreth, D., Müller, J., Unger, A.,https://doi.org/10.1093/cercor/bhw090__Kulik, Á. (2016). KCT auxiliary proteins modulate kinetics of GABAB receptor-mediated inhibition in Cholecystokinin-containing interneurons. Cerebral Cortex. Oxford University Press.https://doi.org/10.1093/cercor/bhw090 

Matsuno, H., Kudoh, M., Watakabe, A., Yamamori, T., Shigemoto, R., &; Nagao, S. (2016). Distribution and structure of synapses on medial vestibular nuclear neurons targeted by cerebellar flocculus purkinje cells and vestibular nerve in mice: Light and electron microscopy studies. PLoS One. Public Library of Science.https://doi.org/10.1371/journal.pone.0164037 

Harada, H., &; Shigemoto, R. (2016). Immunogold protein localization on grid-glued freeze-fracture replicas. In High-Resolution Imaging of Cellular Proteins (Vol. 1474, pp. 203–216). Springer.https://doi.org/10.1007/978-1-4939-6352-2_12 

Nakamura, Y., Harada, H., Kamasawa, N., Matsui, K., Rothman, J., Shigemoto, R.,https://doi.org/10.1016/j.neuron.2014.11.019__Takahashi, T. (2015). Nanoscale distribution of presynaptic C+ channels and its impact on vesicular release during development. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2014.11.019 

Javdani, F., Holló, K., Hegeds, K., Kis, G., Hegyi, Z., Dócs, K.,https://doi.org/10.1002/cne.23774__Antal, M. (2015). Differential expression patterns of K+Cl- cotransporter 2 in neurons within the superficial spinal dorsal horn of rats. Journal of Comparative Neurology. Wiley-Blackwell.https://doi.org/10.1002/cne.23774 

Edamura, M., Murakami, G., Meng, H., Itakura, M., Shigemoto, R., Fukuda, A., &; Nakahara, D. (2014). Functional deficiency of MHC class i enhances LTP and abolishes LTD in the nucleus accumbens of mice. PLoS One. Public Library of Science.https://doi.org/10.1371/journal.pone.0107099 

Ritzau Jost, A., Delvendahl, I., Rings, A., Byczkowicz, N., Harada, H., Shigemoto, R.,https://doi.org/10.1016/j.neuron.2014.08.036__Hallermann, S. (2014). Ultrafast action potentials mediate kilohertz signaling at a central synapse. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2014.08.036 

Wang, W., Nakadate, K., Masugi Tokita, M., Shutoh, F., Aziz, W., Tarusawa, E.,https://doi.org/10.1073/pnas.1315541111__Shigemoto, R. (2014). Distinct cerebellar engrams in short-term and long-term motor learning. PNAS. National Academy of Sciences.https://doi.org/10.1073/pnas.1315541111 

Aziz, W., Wang, W., Kesaf, S., Mohamed, A., Fukazawa, Y., &; Shigemoto, R. (2014). Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning. PNAS. National Academy of Sciences.https://doi.org/10.1073/pnas.1303317110 

Hatakeyama, J., Wakamatsu, Y., Nagafuchi, A., Kageyama, R., Shigemoto, R., &; Shimamura, K. (2014). Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. Company of Biologists.https://doi.org/10.1242/dev.102988 

Matsukawa, H., Akiyoshi Nishimura, S., Zhang, Q., Luján, R., Yamaguchi, K., Goto, H.,https://doi.org/10.1523/JNEUROSCI.1141-14.2014__Itohara, S. (2014). Netrin-G/NGL complexes encode functional synaptic diversification. Journal of Neuroscience. Society for Neuroscience.https://doi.org/10.1523/JNEUROSCI.1141-14.2014 

Rubio, M., Fukazawa, Y., Kamasawa, N., Clarkson, C., Molnár, E., &; Shigemoto, R. (2014). Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus. Journal of Comparative Neurology. Wiley-Blackwell.https://doi.org/10.1002/cne.23654 

Beppu, K., Sasaki, T., Tanaka, K., Yamanaka, A., Fukazawa, Y., Shigemoto, R., &; Matsui, K. (2014). Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage. Neuron. Elsevier.https://doi.org/10.1016/j.neuron.2013.11.011