[{"author":[{"first_name":"Jonas","full_name":"Arruda, Jonas","last_name":"Arruda"},{"full_name":"Alamoudi, Emad","first_name":"Emad","last_name":"Alamoudi"},{"last_name":"Mueller","first_name":"Robert","full_name":"Mueller, Robert"},{"last_name":"Vaisband","full_name":"Vaisband, Marc","first_name":"Marc"},{"full_name":"Molkenbur, Ronja","first_name":"Ronja","last_name":"Molkenbur"},{"orcid":"0000-0001-5145-4609","first_name":"Jack","full_name":"Merrin, Jack","last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kiermaier","full_name":"Kiermaier, Eva","first_name":"Eva"},{"first_name":"Jan","full_name":"Hasenauer, Jan","last_name":"Hasenauer"}],"year":"2026","OA_place":"publisher","pmid":1,"title":"Simulation-based inference of cell migration dynamics in complex spatial environments","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","publication_status":"published","publisher":"Springer Nature","acknowledgement":"This work was supported by the German Federal Ministry of Education and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE, grant agreement number 101126146, and under Germany’s Excellence Strategy by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813, EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn via the Schlegel Professorship of J.H., and the returning experts fellowship of the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is supported by the Institute of Science and Technology Austria. E.K. acknowledges the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments. The authors thank Laeschkir Würthner for his insightful comments on the implementation of the authors’ model. The views and opinions expressed are those of the authors only and do not necessarily reflect those of the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access funding enabled and organized by Projekt DEAL.","status":"public","date_created":"2026-02-16T10:44:31Z","date_published":"2026-02-05T00:00:00Z","day":"05","ddc":["570"],"type":"journal_article","language":[{"iso":"eng"}],"scopus_import":"1","article_number":"20","citation":{"short":"J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin, E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).","ama":"Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell migration dynamics in complex spatial environments. npj Systems Biology and Applications. 2026;12. doi:10.1038/s41540-026-00648-9","chicago":"Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur, Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” Npj Systems Biology and Applications. Springer Nature, 2026. https://doi.org/10.1038/s41540-026-00648-9.","apa":"Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin, J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics in complex spatial environments. Npj Systems Biology and Applications. Springer Nature. https://doi.org/10.1038/s41540-026-00648-9","mla":"Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” Npj Systems Biology and Applications, vol. 12, 20, Springer Nature, 2026, doi:10.1038/s41540-026-00648-9.","ista":"Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in complex spatial environments. npj Systems Biology and Applications. 12, 20.","ieee":"J. Arruda et al., “Simulation-based inference of cell migration dynamics in complex spatial environments,” npj Systems Biology and Applications, vol. 12. Springer Nature, 2026."},"file_date_updated":"2026-02-23T10:09:03Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"gold","PlanS_conform":"1","quality_controlled":"1","has_accepted_license":"1","doi":"10.1038/s41540-026-00648-9","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2056-7189"]},"date_updated":"2026-02-23T10:10:10Z","external_id":{"pmid":["41611727"]},"oa":1,"file":[{"file_id":"21346","content_type":"application/pdf","file_size":10217687,"date_created":"2026-02-23T10:09:03Z","success":1,"creator":"dernst","checksum":"99b2e6bbaaedf45f22e07751948669f5","file_name":"2026_npjSysBioApp_Arruda.pdf","relation":"main_file","date_updated":"2026-02-23T10:09:03Z","access_level":"open_access"}],"_id":"21231","intvolume":" 12","abstract":[{"text":"To assess cell migration in complex spatial environments, microfabricated chips, such as mazes and pillar forests, are routinely used to impose spatial and mechanical constraints, and cell trajectories are followed within these structures by advanced imaging techniques. In systems mechanobiology, computational models serve as essential tools to uncover how physical geometry influences intracellular dynamics; however, decoding such complex behaviors requires advanced inference techniques. Here, we integrated experimental observations of dendritic cell migration in a geometrically constrained microenvironment into a Cellular Potts model. We demonstrated that these spatial constraints modulate the motility dynamics, including speed and directional changes. We show that classical summary statistics, such as mean squared displacement and turning angle distributions, can resolve key mechanistic features but fail to extract richer spatiotemporal patterns, limiting accurate parameter inference. To solve this, we applied neural posterior estimation with in-the-loop learning of summary features. This learned summary representation of the data enables robust and flexible parameter inference, providing a data-driven framework for model calibration and advancing quantitative analysis of cell migration in structured microenvironments.","lang":"eng"}],"month":"02","article_type":"original","DOAJ_listed":"1","volume":12,"publication":"npj Systems Biology and Applications","department":[{"_id":"NanoFab"}]},{"publisher":"Institute of Science and Technology Austria","tmp":{"legal_code_url":"https://www.gnu.org/licenses/gpl-3.0.en.html","short":"GPL 3.0","name":"GNU General Public License 3.0"},"has_accepted_license":"1","doi":"10.15479/AT-ISTA-21442","project":[{"_id":"e62b56fe-ab3c-11f0-94c7-d181dd352b3b","grant_number":"101199096","name":"Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits"},{"name":"Mechanisms of GABA release in hippocampal circuits","grant_number":"P36232","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5"},{"_id":"8d9195e9-16d5-11f0-9cad-d075be887a1e","name":"Synaptic networks of human brain","grant_number":"PAT 4178023"},{"name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"}],"date_created":"2026-03-12T08:20:46Z","status":"public","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","author":[{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","last_name":"Schlögl","first_name":"Alois","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100"}],"year":"2026","file_date_updated":"2026-03-12T10:24:45Z","citation":{"ama":"Schlögl A. CA3Simu v1.06 (vargas2026v1). 2026. doi:10.15479/AT-ISTA-21442","short":"A. Schlögl, (2026).","ieee":"A. Schlögl, “CA3Simu v1.06 (vargas2026v1).” Institute of Science and Technology Austria, 2026.","ista":"Schlögl A. 2026. CA3Simu v1.06 (vargas2026v1), Institute of Science and Technology Austria, 10.15479/AT-ISTA-21442.","apa":"Schlögl, A. (2026). CA3Simu v1.06 (vargas2026v1). Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21442","mla":"Schlögl, Alois. CA3Simu v1.06 (Vargas2026v1). Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21442.","chicago":"Schlögl, Alois. “CA3Simu v1.06 (Vargas2026v1).” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21442."},"title":"CA3Simu v1.06 (vargas2026v1)","ec_funded":1,"license":"https://opensource.org/licenses/GPL-3.0","month":"03","file":[{"creator":"schloegl","checksum":"441c8827717dcda05f91c127d15cf1e9","file_id":"21443","content_type":"application/gzip","date_created":"2026-03-12T08:19:14Z","success":1,"file_size":160410,"relation":"main_file","access_level":"open_access","date_updated":"2026-03-12T08:19:14Z","file_name":"ca3simu-vargas2026v1.tar.gz"},{"creator":"schloegl","checksum":"3c0092076228a15c0a7ae703192d43ea","file_id":"21445","success":1,"date_created":"2026-03-12T10:24:45Z","file_size":10923,"content_type":"text/markdown","relation":"main_file","access_level":"open_access","date_updated":"2026-03-12T10:24:45Z","file_name":"README.md"}],"day":"12","_id":"21442","type":"software","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"keyword":["hypocampus","ca3 simulations","modelling"],"date_published":"2026-03-12T00:00:00Z","date_updated":"2026-03-12T11:28:52Z","oa":1,"corr_author":"1"},{"main_file_link":[{"url":"https://doi.org/10.1177/00236772251400976","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Gonzalez-Uarquin F, Jirkof P, Bert B, et al. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. 2026. doi:10.1177/00236772251400976","short":"F. Gonzalez-Uarquin, P. Jirkof, B. Bert, P. Hawkins, L. Angelovski, J. Baumgart, N. Baumgart, Ö.S. Cevik, N.H. Franco, E. Horata, R. Kaura, W. Neuhaus, B. Riso, A.J. Smith, A. Sotiropoulos, A. Vitale, S. Schober, Laboratory Animals (2026).","ieee":"F. Gonzalez-Uarquin et al., “Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science,” Laboratory Animals. SAGE Publications, 2026.","mla":"Gonzalez-Uarquin, Fernando, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals, SAGE Publications, 2026, doi:10.1177/00236772251400976.","ista":"Gonzalez-Uarquin F, Jirkof P, Bert B, Hawkins P, Angelovski L, Baumgart J, Baumgart N, Cevik ÖS, Franco NH, Horata E, Kaura R, Neuhaus W, Riso B, Smith AJ, Sotiropoulos A, Vitale A, Schober S. 2026. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals.","apa":"Gonzalez-Uarquin, F., Jirkof, P., Bert, B., Hawkins, P., Angelovski, L., Baumgart, J., … Schober, S. (2026). Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. SAGE Publications. https://doi.org/10.1177/00236772251400976","chicago":"Gonzalez-Uarquin, Fernando, Paulin Jirkof, Bettina Bert, Penny Hawkins, Ljupco Angelovski, Jan Baumgart, Nadine Baumgart, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals. SAGE Publications, 2026. https://doi.org/10.1177/00236772251400976."},"quality_controlled":"1","OA_type":"hybrid","doi":"10.1177/00236772251400976","publication_identifier":{"eissn":["1758-1117"],"issn":["0023-6772"]},"date_updated":"2026-04-28T12:22:17Z","oa":1,"article_type":"original","month":"04","abstract":[{"text":"The involvement of non-scientific staff in discussions about animal welfare and scientific quality is essential for biomedical research progress. In this study, we developed a survey to collect the self-perception of animal care staff (ACS) and laboratory technicians about their involvement in scientific planning and conduct. Participants were contacted to complete an anonymous online questionnaire. We obtained 850 responses, mainly from Europe: 564 from ACS and 286 from laboratory technicians. Job satisfaction was assessed as positive by ACS and laboratory technicians despite the low frequency of culture of care activities and mental health meetings. Both groups expressed their desire to be trained in research planning and conduct; however, regular training was not reported. In addition, the inability to act on animal welfare concerns owing to experimental reasons was reported by both groups. Over half of the participants felt valued and appreciated by the lead scientists or animal facility manager; however, it is not clear how they are acknowledged, as their names on the authors list or in the manuscript acknowledgments are barely included. Our results indicated that involvement of ACS and laboratory technicians in planning and conducting studies would improve their understanding of how experiments are done, and therefore communication processes, work satisfaction, animal welfare, and scientific quality. Finally, we provided recommendations to improve the engagement of ACS and laboratory technicians in discussions about animal research planning and conduct.","lang":"eng"},{"text":"La participation de personnel non-scientifique aux discussions sur le bien-être animal et la qualité scientifique est essentielle aux progrès la recherche biomédicale. Dans cette étude, nous avons développé une enquête pour recueillir l'auto-perception du personnel chargé des soins prodigués aux animaux (PCSA) et des techniciens de laboratoire (TL) sur leur implication dans la planification et la conduite scientifiques. Les participants ont été contactés pour remplir un questionnaire anonyme en ligne. Nous avons obtenu 850 réponses, principalement en Europe : 564 provenant de PCSA et 286 de TL. La satisfaction au travail a été évaluée comme positive par le PCSA et les TL malgré la faible fréquence d’activités sur la culture des soins et de réunions concernant la santé mentale. Bien que les deux groupes aient exprimé leur désir d'être formés à la planification et à la conduite de la recherche, aucune formation réelle régulière n'a été signalée. De plus, l'incapacité d'agir sur les préoccupations relatives au bien-être animal pour des raisons expérimentales a été signalée par les deux groupes. Plus de la moitié des participants se sont sentis valorisés et appréciés par les scientifiques principaux ou le gestionnaire de l’installation animale mais on ne sait pas clairement comment ils sont reconnus, car leurs noms sur la liste des auteurs ou dans les remerciements sont à peine inclus dans la documentation. Nos résultats ont indiqué que la participation du PCSA et des TL à la planification et à la conduite des études améliorerait leur compréhension de la façon dont les expériences sont effectuées et, par conséquent, les processus de communication, leur satisfaction au travail ainsi que le bien-être animal et la qualité scientifique. Enfin, nous avons formulé des recommandations pour améliorer la participation du PCSA et des TL aux discussions sur la planification et la conduite de la recherche animale.","lang":"fre"},{"text":"Die Einbeziehung von nichtwissenschaftlichem Personal in Diskussionen über Tierschutz und wissenschaftliche Qualität ist für Fortschritte in biomedizinischer Forschung von entscheidender Bedeutung. In dieser Studie haben wir eine Umfrage entwickelt, um die Selbsteinschätzung von Tierpflegern (ACS) und Labortechnikern (LT) hinsichtlich ihrer Beteiligung an der wissenschaftlichen Planung und Durchführung zu erfassen. Die Teilnehmer wurden gebeten, einen anonymen Online-Fragebogen auszufüllen. Wir erhielten 850 Rückmeldungen, hauptsächlich aus Europa: 564 von ACS und 286 von LT. Die Arbeitszufriedenheit wurde von ACS und LT trotz der geringen Häufigkeit von Pflegeaktivitäten und Treffen zum Thema psychische Gesundheit als positiv bewertet. Beide Gruppen äußerten den Wunsch, in der Forschungsplanung und -durchführung geschult zu werden, doch regelmäßig stattfindende Schulungen wurden nicht berichtet. Außerdem wurde von beiden Gruppen vermeldet, dass sie aus versuchstechnischen Gründen nicht in der Lage waren, auf Tierschutzbedenken zu reagieren. Über die Hälfte der Teilnehmer fühlte sich von den leitenden Wissenschaftlern oder dem Leiter der Tierhaltungseinrichtung geschätzt und anerkannt; es ist jedoch unklar, inwiefern sie wirklich gewürdigt werden, da ihre Namen kaum in der Autorenliste oder in den Danksagungen des Manuskripts aufgeführt sind. Unsere Ergebnisse deuteten darauf hin, dass die Einbeziehung von ACS und LT in die Planung und Durchführung von Studien ihr Verständnis für die Durchführung von Experimenten verbessern würde – und damit auch Kommunikationsprozesse, Arbeitszufriedenheit, Tierwohl und wissenschaftliche Qualität. Abschließend gaben wir Empfehlungen zur Verbesserung der Einbeziehung von ACS und LT in Diskussionen über die Planung und Durchführung von Tierversuchen.","lang":"ger"},{"text":"La participación del personal no científico en los debates sobre el bienestar animal y la calidad científica es fundamental para el avance de la investigación biomédica. En este estudio, desarrollamos una encuesta para recoger la autopercepción del personal encargado del cuidado de los animales (ACS) y de los técnicos de laboratorio (LT) sobre su implicación en la planificación y la realización científicas. Se contactó con los participantes para que cumplimentaran un cuestionario anónimo en línea. Obtuvimos 850 respuestas, principalmente de Europa: 564 de ACS y 286 de LT. La satisfacción laboral fue evaluada como positiva por ACS y técnicos de laboratorio a pesar de la baja frecuencia de actividades de cultura del cuidado y reuniones sobre bienestar mental. Ambos grupos expresaron su deseo de recibir formación en planificación y realización de investigaciones, sin embargo, no se informó sobre una formación regular. Asimismo, ambos grupos señalaron la incapacidad de actuar ante las preocupaciones sobre el bienestar animal por motivos experimentales. Más de la mitad de los participantes se sintieron valorados y apreciados por los científicos principales o el responsable de las instalaciones de animales; sin embargo, no está claro cómo se les reconoce, ya que apenas se incluyen sus nombres en la lista de autores o en los agradecimientos del manuscrito. Nuestros resultados indicaron que la participación de los ACS y los LT en la planificación y realización de los estudios mejoraría su comprensión de cómo se hacen los experimentos y, por tanto, los procesos de comunicación, la satisfacción laboral, el bienestar animal y la calidad científica. Finalmente, proporcionamos recomendaciones para mejorar el compromiso de la AEC y la LT en los debates sobre la planificación y la realización de investigaciones con animales.","lang":"spa"}],"_id":"21767","publication":"Laboratory Animals","department":[{"_id":"PreCl"}],"OA_place":"publisher","author":[{"last_name":"Gonzalez-Uarquin","first_name":"Fernando","full_name":"Gonzalez-Uarquin, Fernando"},{"full_name":"Jirkof, Paulin","first_name":"Paulin","last_name":"Jirkof"},{"last_name":"Bert","first_name":"Bettina","full_name":"Bert, Bettina"},{"last_name":"Hawkins","first_name":"Penny","full_name":"Hawkins, Penny"},{"last_name":"Angelovski","first_name":"Ljupco","full_name":"Angelovski, Ljupco"},{"last_name":"Baumgart","full_name":"Baumgart, Jan","first_name":"Jan"},{"full_name":"Baumgart, Nadine","first_name":"Nadine","last_name":"Baumgart"},{"last_name":"Cevik","full_name":"Cevik, Özge S.","first_name":"Özge S."},{"full_name":"Franco, Nuno H.","first_name":"Nuno H.","last_name":"Franco"},{"last_name":"Horata","first_name":"Erdal","full_name":"Horata, Erdal"},{"last_name":"Kaura","first_name":"Rohish","full_name":"Kaura, Rohish"},{"last_name":"Neuhaus","first_name":"Winfried","full_name":"Neuhaus, Winfried"},{"full_name":"Riso, Brigida","first_name":"Brigida","last_name":"Riso"},{"last_name":"Smith","full_name":"Smith, Adrian J.","first_name":"Adrian J."},{"last_name":"Sotiropoulos","first_name":"Athanassia","full_name":"Sotiropoulos, Athanassia"},{"full_name":"Vitale, Augusto","first_name":"Augusto","last_name":"Vitale"},{"first_name":"Sophie","full_name":"Schober, Sophie","last_name":"Schober","id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8"}],"year":"2026","article_processing_charge":"Yes (in subscription journal)","title":"Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science","oa_version":"Published Version","publisher":"SAGE Publications","publication_status":"epub_ahead","acknowledgement":"We deeply acknowledge all the animal care staff and laboratory technicians who participated in this study! We acknowledge Working Groups 1 and 4 from COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology) for their feedback and support. We also acknowledge Aoife Milford for her comments and contributions to the final draft of the manuscript.\r\nThis publication was based on work from the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology).","date_created":"2026-04-26T22:01:47Z","status":"public","date_published":"2026-04-14T00:00:00Z","day":"14","type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}]},{"page":"626-631","ddc":["540"],"day":"18","type":"journal_article","language":[{"iso":"eng"}],"date_published":"2026-03-18T00:00:00Z","issue":"8106","publisher":"Springer Nature","publication_status":"published","project":[{"grant_number":"949120","name":"Tribocharge: a multi-scale approach to an enduring problem in physics","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","call_identifier":"H2020"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"acknowledgement":"This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant agreement no. 754411). We acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility and Lab Support Facility. We thank the Modic group for the use of the Laue camera, T. Zauner for the photography of the experimental set-up and R. Möller for insightful discussions. Open access funding provided by Institute of Science and Technology (IST Austria).","status":"public","date_created":"2026-03-23T15:04:00Z","OA_place":"publisher","author":[{"orcid":"0000-0001-5154-417X","first_name":"Galien M","full_name":"Grosjean, Galien M","last_name":"Grosjean","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425"},{"first_name":"Markus","full_name":"Ostermann, Markus","last_name":"Ostermann"},{"first_name":"Markus","full_name":"Sauer, Markus","last_name":"Sauer"},{"full_name":"Hahn, Michael","first_name":"Michael","last_name":"Hahn"},{"last_name":"Pichler","first_name":"Christian M.","full_name":"Pichler, Christian M."},{"first_name":"Florian","full_name":"Fahrnberger, Florian","last_name":"Fahrnberger"},{"orcid":"0000-0003-0463-5794","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","last_name":"Pertl","first_name":"Felix","full_name":"Pertl, Felix"},{"last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","first_name":"Daniel","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X"},{"last_name":"Link","full_name":"Link, Mason M.","first_name":"Mason M."},{"last_name":"Kim","first_name":"Seong H.","full_name":"Kim, Seong H."},{"first_name":"Devin L.","full_name":"Schrader, Devin L.","last_name":"Schrader"},{"full_name":"Blanco, Adriana","first_name":"Adriana","last_name":"Blanco"},{"full_name":"Gracia, Francisco","first_name":"Francisco","last_name":"Gracia"},{"last_name":"Mujica","full_name":"Mujica, Nicolás","first_name":"Nicolás"},{"orcid":"0000-0002-2299-3176","last_name":"Waitukaitis","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","first_name":"Scott R","full_name":"Waitukaitis, Scott R"}],"year":"2026","title":"Adventitious carbon breaks symmetry in oxide contact electrification","article_processing_charge":"Yes (via OA deal)","ec_funded":1,"oa_version":"Published Version","pmid":1,"article_type":"original","month":"03","file":[{"checksum":"dafef9ed575b44be4263e948a47ae056","creator":"dernst","content_type":"application/pdf","date_created":"2026-03-24T06:57:08Z","file_size":12245694,"success":1,"file_id":"21494","access_level":"open_access","date_updated":"2026-03-24T06:57:08Z","relation":"main_file","file_name":"2026_Nature_Grosjean.pdf"}],"abstract":[{"text":"Insulating oxides are among the most abundant solid materials in the universe1,2,3. Of the many ways in which they influence natural phenomena, perhaps the most consequential is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which occurs even between samples of the same oxide—yet the symmetry-breaking parameter that causes this remains unidentified11,12. Here we show that adventitious carbonaceous molecules adsorbed from the environment are the symmetry-breaking factor in same-material oxide contact electrification (CE). We use acoustic levitation to measure charge exchange between a sphere and a plate composed of identical amorphous silicon dioxide (SiO2). Although charging polarity is random for co-prepared samples, we control it with baking or plasma treatment. Observing the charge-exchange relaxation afterwards, we see dynamics over a timescale of hours and connect this directly to the presence of adventitious carbon with time-of-flight mass spectrometry, low-energy ion scattering and infrared spectroscopy. Going further, we confirm that adventitious carbon can even determine charge exchange among different oxides. Our results identify the symmetry-breaking parameter that causes insulating oxides to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6, while simultaneously highlighting an overlooked factor in CE more broadly.","lang":"eng"}],"_id":"21485","intvolume":" 651","publication":"Nature","department":[{"_id":"ScWa"},{"_id":"GradSch"},{"_id":"LifeSc"}],"volume":651,"date_updated":"2026-04-28T12:06:01Z","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/"}]},"external_id":{"pmid":["41851325"]},"oa":1,"corr_author":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","doi":"10.1038/s41586-025-10088-w","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ama":"Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w","short":"G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger, F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia, N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.","ieee":"G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide contact electrification,” Nature, vol. 651, no. 8106. Springer Nature, pp. 626–631, 2026.","ista":"Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 651(8106), 626–631.","mla":"Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp. 626–31, doi:10.1038/s41586-025-10088-w.","apa":"Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger, F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w","chicago":"Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-10088-w."},"file_date_updated":"2026-03-24T06:57:08Z","quality_controlled":"1","OA_type":"hybrid","PlanS_conform":"1"},{"day":"16","ddc":["530"],"type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}],"date_published":"2026-02-16T00:00:00Z","publisher":"Springer Nature","publication_status":"published","acknowledgement":"We are grateful to A. G. Volosniev for the valuable discussions. We thank D. Milius for the assistance with microscopy. D. R. would like to thank F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).","status":"public","date_created":"2026-03-02T10:06:58Z","OA_place":"publisher","author":[{"full_name":"Rak, Dmytro","first_name":"Dmytro","id":"70313b46-47c2-11ec-9e88-cd79101918fe","last_name":"Rak"},{"first_name":"Dusan","full_name":"Lorenc, Dusan","last_name":"Lorenc","id":"40D8A3E6-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-7597-043X","first_name":"Daniel","full_name":"Balazs, Daniel","last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E"},{"full_name":"Zhumekenov, Ayan A.","first_name":"Ayan A.","last_name":"Zhumekenov"},{"last_name":"Bakr","first_name":"Osman M.","full_name":"Bakr, Osman M."},{"id":"45E67A2A-F248-11E8-B48F-1D18A9856A87","last_name":"Alpichshev","first_name":"Zhanybek","full_name":"Alpichshev, Zhanybek","orcid":"0000-0002-7183-5203"}],"year":"2026","article_processing_charge":"Yes","title":"Flexoelectric domain walls enable charge separation and transport in cubic perovskites","oa_version":"Published Version","pmid":1,"article_type":"original","month":"02","file":[{"file_id":"21390","date_created":"2026-03-02T14:27:56Z","success":1,"file_size":2570918,"content_type":"application/pdf","creator":"dernst","checksum":"dd7a98de892d0b5abefca7e290ca0f77","file_name":"2026_NatureComm_Rak.pdf","relation":"main_file","date_updated":"2026-03-02T14:27:56Z","access_level":"open_access"}],"_id":"21382","intvolume":" 17","abstract":[{"text":"The exceptional energy-harvesting efficiency of lead-halide perovskites arises from unusually long photocarrier diffusion lengths and recombination lifetimes that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites are also known for having very short exciton decay times. Here, we resolve this apparent contradiction by showing that key optoelectronic properties of perovskites can be explained by localized flexoelectric polarization confined to interfaces between domains of spontaneous strain. Using birefringence imaging, electrochemical staining, and zero-bias photocurrent measurements, we visualize the domain structure and directly probe the associated internal fields in nominally cubic single crystals of methylammonium lead bromide. We demonstrate that localized flexoelectric fields spatially separate electrons and holes to opposite sides of domain walls, exponentially suppressing recombination. Domain walls thus act as efficient mesoscopic transport channels for long-lived photocarriers, microscopically linking structural heterogeneity to charge transport and offering mechanistically informed design principles for perovskite solar-energy technologies.","lang":"eng"}],"publication":"Nature Communications","department":[{"_id":"ZhAl"},{"_id":"LifeSc"}],"DOAJ_listed":"1","volume":17,"date_updated":"2026-04-28T12:12:46Z","related_material":{"link":[{"url":"https://ista.ac.at/en/news/explaining-next-generation-solar-cells/","relation":"press_release","description":"News on ISTA website"}]},"external_id":{"pmid":["41698893"]},"corr_author":"1","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","doi":"10.1038/s41467-026-68660-5","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"}],"publication_identifier":{"eissn":["2041-1723"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_number":"946","file_date_updated":"2026-03-02T14:27:56Z","citation":{"ama":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 2026;17. doi:10.1038/s41467-026-68660-5","short":"D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev, Nature Communications 17 (2026).","ieee":"D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev, “Flexoelectric domain walls enable charge separation and transport in cubic perovskites,” Nature Communications, vol. 17. Springer Nature, 2026.","apa":"Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., & Alpichshev, Z. (2026). Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-68660-5","mla":"Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications, vol. 17, 946, Springer Nature, 2026, doi:10.1038/s41467-026-68660-5.","ista":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 17, 946.","chicago":"Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M. Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-68660-5."},"quality_controlled":"1","OA_type":"gold","PlanS_conform":"1"},{"date_published":"2026-04-16T00:00:00Z","issue":"6795","day":"16","type":"journal_article","language":[{"iso":"eng"}],"scopus_import":"1","author":[{"id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083","last_name":"Springstein","first_name":"Benjamin L","full_name":"Springstein, Benjamin L","orcid":"0000-0002-3461-5391"},{"last_name":"Javoor","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","full_name":"Javoor, Manjunath","first_name":"Manjunath","orcid":"0000-0003-2311-2112"},{"last_name":"Megrian","first_name":"Daniela","full_name":"Megrian, Daniela"},{"full_name":"Hajdu, Roman","first_name":"Roman","last_name":"Hajdu","id":"ffab949d-133f-11ed-8f02-94de21ace503"},{"first_name":"Dustin M.","full_name":"Hanke, Dustin M.","last_name":"Hanke"},{"last_name":"Zens","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","first_name":"Bettina","full_name":"Zens, Bettina","orcid":"0000-0002-9561-1239"},{"last_name":"Weiss","first_name":"Gregor L.","full_name":"Weiss, Gregor L."},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","full_name":"Schur, Florian Km","first_name":"Florian Km","orcid":"0000-0003-4790-8078"},{"orcid":"0000-0001-7309-9724","first_name":"Martin","full_name":"Loose, Martin","last_name":"Loose","id":"462D4284-F248-11E8-B48F-1D18A9856A87"}],"year":"2026","pmid":1,"article_processing_charge":"No","title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","ec_funded":1,"oa_version":"None","publication_status":"published","publisher":"AAAS","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","status":"public","date_created":"2026-04-26T22:01:46Z","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","grant_number":"101076260","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery"}],"date_updated":"2026-04-28T13:29:05Z","external_id":{"pmid":["41990175"]},"corr_author":"1","_id":"21762","abstract":[{"lang":"eng","text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria."}],"intvolume":" 392","month":"04","article_type":"original","volume":392,"publication":"Science","department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"article_number":"eaea6343","citation":{"ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795). doi:10.1126/science.aea6343","short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026).","ieee":"B. L. Springstein et al., “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” Science, vol. 392, no. 6795. AAAS, 2026.","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.","apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343","ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"closed access","quality_controlled":"1","doi":"10.1126/science.aea6343","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}]},{"has_accepted_license":"1","doi":"10.3390/proteomes14010010","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2227-7382"]},"article_number":"10","file_date_updated":"2026-05-04T10:31:35Z","citation":{"chicago":"Miletić Vukajlović, Jadranka, Bojana Ilić, Bella Bruszel, Tanja Panić-Janković, and Goran Mitulović. “Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” Proteomes. MDPI, 2026. https://doi.org/10.3390/proteomes14010010.","apa":"Miletić Vukajlović, J., Ilić, B., Bruszel, B., Panić-Janković, T., & Mitulović, G. (2026). Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. Proteomes. MDPI. https://doi.org/10.3390/proteomes14010010","ista":"Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. 2026. Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. Proteomes. 14(1), 10.","mla":"Miletić Vukajlović, Jadranka, et al. “Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” Proteomes, vol. 14, no. 1, 10, MDPI, 2026, doi:10.3390/proteomes14010010.","ieee":"J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, and G. Mitulović, “Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses,” Proteomes, vol. 14, no. 1. MDPI, 2026.","short":"J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, G. Mitulović, Proteomes 14 (2026).","ama":"Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. Proteomes. 2026;14(1). doi:10.3390/proteomes14010010"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"gold","PlanS_conform":"1","quality_controlled":"1","file":[{"file_name":"2026_Proteomes_Vukajlovic.pdf","access_level":"open_access","date_updated":"2026-05-04T10:31:35Z","relation":"main_file","content_type":"application/pdf","date_created":"2026-05-04T10:31:35Z","success":1,"file_size":1009723,"file_id":"21790","checksum":"1e0c66bbf4b6e0be626a8639ea664b63","creator":"dernst"}],"_id":"21711","abstract":[{"lang":"eng","text":"Background: Low-volume trapping columns are essential for sample enrichment, desalting, and injection profile focusing on nano-LC–MS-based proteomics. They enable higher sample loading, improve chromatographic performance, and protect the analytical column by removing salts and contaminants. Recently, monolithic trap columns with micropillar architecture have emerged as alternatives to conventionally packed traps. This study compares the performance of a packed and a micropillar monolithic trap column for the analysis of tryptic peptides. Methods: A tryptic digest of HeLa cell lysate was analyzed under identical LC–MS conditions using both trap types. Peptides were detected at 214 nm and analyzed by nano-ESI on a Q Exactive Plus Orbitrap. Data were searched against the human UniProt database (February 2023) using FragPipe v20.0, and statistical evaluation of MaxLFQ intensities was performed in Perseus using Welch’s t-test and clustering analysis. Results: Over 2500 proteins were identified with both setups. The packed trap column yielded more total peptides, particularly those with post-translational modifications and higher hydrophilicity, whereas the monolithic column favored peptides of intermediate hydrophobicity. Chromatographic profiles confirmed a slight reduction in the trapping efficiency of hydrophilic peptides by the monolithic trap. Conclusions: Trap column design significantly influences peptide recovery and proteome coverage."}],"intvolume":" 14","month":"03","article_type":"original","DOAJ_listed":"1","volume":14,"publication":"Proteomes","department":[{"_id":"MassSpec"}],"date_updated":"2026-05-04T10:36:21Z","external_id":{"pmid":["41893725"]},"oa":1,"publication_status":"published","publisher":"MDPI","acknowledgement":"The authors thank Gábor Tóth, Uppsala University, Sweden, and Armel Nicolas, Institute for Science and Technology Austria, for their support. This research was conducted during a student residency in Vienna under the auspices of OeAD. ZI: ICM-2016-03196.","status":"public","date_created":"2026-04-12T22:01:49Z","author":[{"first_name":"Jadranka","full_name":"Miletić Vukajlović, Jadranka","last_name":"Miletić Vukajlović"},{"first_name":"Bojana","full_name":"Ilić, Bojana","last_name":"Ilić"},{"last_name":"Bruszel","id":"70abbbb3-88ea-11ec-8e0a-e8c939944834","full_name":"Bruszel, Bella","first_name":"Bella"},{"last_name":"Panić-Janković","full_name":"Panić-Janković, Tanja","first_name":"Tanja"},{"last_name":"Mitulović","first_name":"Goran","full_name":"Mitulović, Goran"}],"year":"2026","OA_place":"publisher","pmid":1,"article_processing_charge":"Yes","title":"Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses","oa_version":"Published Version","day":"01","ddc":["540"],"type":"journal_article","language":[{"iso":"eng"}],"scopus_import":"1","date_published":"2026-03-01T00:00:00Z","issue":"1"},{"scopus_import":"1","language":[{"iso":"eng"}],"type":"journal_article","ddc":["570"],"day":"28","issue":"4","date_published":"2026-04-28T00:00:00Z","project":[{"_id":"ebb66355-77a9-11ec-83b8-b8ac210a4dae","grant_number":"101041551","name":"Development and Evolution of Tetrapod Motor Circuits"},{"_id":"8da85f50-16d5-11f0-9cad-eab8b0ff6c9e","name":"Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb transition: cell type to connection diversity","grant_number":"F7814"},{"name":"Tools for automation and feedback microscopy","grant_number":"CZI01","_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473"},{"grant_number":"FTI21-D-046","name":"Development of V1 interneuron diversity during swim-to-walk transition of Xenopus metamorphosis","_id":"bd73af52-d553-11ed-ba76-912049f0ac7a"}],"status":"public","date_created":"2026-04-19T22:07:43Z","acknowledgement":"We would like to thank the members of the Sweeney Lab, Mario de Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript. We are also grateful to Tom Jessell and Chris Kintner for their scientific insight and mentorship during the conception of this project. It would also have not been possible without the technical support of the Aquatics and Imaging and Optics Facility support teams (ISTA). We thank Martin Estermann for preparing the initial draft of the graphical abstract and Niki Barolini for the final version. In addition, we thank our funding sources for providing the resources to do these experiments: GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.), Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858 (to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC) (to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472 (to Z.H.), and Project A.L.S. (to S.B.-M.).","publisher":"Elsevier","publication_status":"published","oa_version":"Published Version","title":"Multifold increase in spinal inhibitory cell types with emergence of limb movement","article_processing_charge":"Yes","pmid":1,"OA_place":"publisher","year":"2026","author":[{"id":"cf391e77-ec3c-11ea-a124-d69323410b58","last_name":"Vijatovic","full_name":"Vijatovic, David","first_name":"David"},{"id":"2f73f876-f128-11eb-9611-b96b5a30cb0e","last_name":"Toma","full_name":"Toma, Florina Alexandra ","first_name":"Florina Alexandra "},{"last_name":"Ignatyev","first_name":"Y","full_name":"Ignatyev, Y"},{"first_name":"Zoe P","full_name":"Harrington, Zoe P","last_name":"Harrington","id":"a8144562-32c9-11ee-b5ce-d9800628bda2","orcid":"0009-0008-0158-4032"},{"first_name":"Christoph M","full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","last_name":"Sommer","orcid":"0000-0003-1216-9105"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild","full_name":"Hauschild, Robert","first_name":"Robert","orcid":"0000-0001-9843-3522"},{"last_name":"Smits","id":"7a231d52-e216-11ee-a0bb-8acd55f8f1f0","first_name":"Matthijs Geert","full_name":"Smits, Matthijs Geert"},{"first_name":"Marco","full_name":"Dalla Vecchia, Marco","last_name":"Dalla Vecchia","id":"02a7a869-ff06-11ed-a87f-86649d6077e5"},{"last_name":"Trevisan","first_name":"Alexandra J.","full_name":"Trevisan, Alexandra J."},{"last_name":"Chapman","first_name":"Phillip","full_name":"Chapman, Phillip"},{"id":"1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1","last_name":"Julseth","full_name":"Julseth, Mara","first_name":"Mara"},{"first_name":"Susan","full_name":"Brenner-Morton, Susan","last_name":"Brenner-Morton"},{"first_name":"Mariano I.","full_name":"Gabitto, Mariano I.","last_name":"Gabitto"},{"last_name":"Dasen","first_name":"Jeremy S.","full_name":"Dasen, Jeremy S."},{"first_name":"Jay B.","full_name":"Bikoff, Jay B.","last_name":"Bikoff"},{"orcid":"0000-0001-9242-5601","first_name":"Lora Beatrice Jaeger","full_name":"Sweeney, Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","last_name":"Sweeney"}],"department":[{"_id":"LoSw"},{"_id":"GradSch"},{"_id":"TiVo"},{"_id":"Bio"},{"_id":"NiBa"}],"publication":"Cell Reports","volume":45,"DOAJ_listed":"1","month":"04","article_type":"original","_id":"21746","intvolume":" 45","abstract":[{"text":"As vertebrates transitioned from water to land, locomotion shifted from undulatory swimming to limb-based movement. How spinal circuits and their cell types evolved to support this transition remains unclear. We leverage frog metamorphosis, which recapitulates this transition within a single organism, to define how spinal circuits generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons. As limbs develop and their movement complexifies, spinal circuits expand in neuron number and subtype diversity. This expansion is most pronounced for V1 inhibitory neurons, which increase ∼70-fold and diversify into transcriptionally distinct subtypes. Disrupting transcription factors defining emerging motor and V1 populations reveals molecular segregation between swim and limb circuits, highlighting the role of subtype diversity in motor coordination. A multifold increase in inhibitory neuron diversity thus underlies the tail-to-limb locomotor transition, providing a framework for spinal circuit adaptation during vertebrate evolution.","lang":"eng"}],"file":[{"file_name":"2026_CellReports_Vijatovic.pdf","relation":"main_file","date_updated":"2026-05-04T12:20:10Z","access_level":"open_access","file_id":"21795","content_type":"application/pdf","date_created":"2026-05-04T12:20:10Z","success":1,"file_size":14925958,"creator":"dernst","checksum":"0d26cdb5b8d8dec3a911d8261a65cdef"}],"oa":1,"corr_author":"1","external_id":{"pmid":["41964955 "]},"date_updated":"2026-05-04T12:27:06Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["2639-1856"],"eissn":["2211-1247"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1016/j.celrep.2026.117227","has_accepted_license":"1","quality_controlled":"1","PlanS_conform":"1","OA_type":"gold","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2026-05-04T12:20:10Z","citation":{"ieee":"D. Vijatovic et al., “Multifold increase in spinal inhibitory cell types with emergence of limb movement,” Cell Reports, vol. 45, no. 4. Elsevier, 2026.","chicago":"Vijatovic, David, Florina Alexandra Toma, Y Ignatyev, Zoe P Harrington, Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” Cell Reports. Elsevier, 2026. https://doi.org/10.1016/j.celrep.2026.117227.","ista":"Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. 45(4), 117227.","mla":"Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” Cell Reports, vol. 45, no. 4, 117227, Elsevier, 2026, doi:10.1016/j.celrep.2026.117227.","apa":"Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M., Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2026.117227","ama":"Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. 2026;45(4). doi:10.1016/j.celrep.2026.117227","short":"D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild, M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton, M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026)."},"article_number":"117227"},{"OA_type":"gold","quality_controlled":"1","file_date_updated":"2026-05-07T08:21:06Z","citation":{"chicago":"Vignolle, Anna, Martin Zehl, Jaime Felipe Guerrero Garzón, Olha Schneider, Johannes Gafriller, Ulrike Grienke, Rasmus H. Kirkegaard, and Sergey B. Zotchev. “Identification and Characterisation of the Gene Cluster Governing Biosynthesis of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial Biotechnology. Wiley, 2026. https://doi.org/10.1111/1751-7915.70357.","mla":"Vignolle, Anna, et al. “Identification and Characterisation of the Gene Cluster Governing Biosynthesis of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial Biotechnology, vol. 19, no. 4, e70357, Wiley, 2026, doi:10.1111/1751-7915.70357.","ista":"Vignolle A, Zehl M, Garzón JFG, Schneider O, Gafriller J, Grienke U, Kirkegaard RH, Zotchev SB. 2026. Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. 19(4), e70357.","apa":"Vignolle, A., Zehl, M., Garzón, J. F. G., Schneider, O., Gafriller, J., Grienke, U., … Zotchev, S. B. (2026). Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. Wiley. https://doi.org/10.1111/1751-7915.70357","ieee":"A. Vignolle et al., “Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin,” Microbial Biotechnology, vol. 19, no. 4. Wiley, 2026.","short":"A. Vignolle, M. Zehl, J.F.G. Garzón, O. Schneider, J. Gafriller, U. Grienke, R.H. Kirkegaard, S.B. Zotchev, Microbial Biotechnology 19 (2026).","ama":"Vignolle A, Zehl M, Garzón JFG, et al. Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. 2026;19(4). doi:10.1111/1751-7915.70357"},"article_number":"e70357","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1751-7915"]},"doi":"10.1111/1751-7915.70357","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"external_id":{"pmid":["42036976"]},"date_updated":"2026-05-07T08:22:41Z","volume":19,"DOAJ_listed":"1","department":[{"_id":"MassSpec"}],"publication":"Microbial Biotechnology","_id":"21779","intvolume":" 19","abstract":[{"text":"Acidomycin is an anti-mycobacterial antibiotic with a unique mode of action, targeting the biotin biosynthesis pathway. Despite being highly active against mycobacteria in vitro, its development as an anti-tubercular agent has been hindered due to suboptimal pharmacokinetics. Engineering of the acidomycin biosynthesis may yield new analogues with improved pharmacological properties. Here, we describe the identification of the acidomycin biosynthetic gene cluster (BGC) in a Streptomyces bacterium isolated from the rhizosphere of Edelweiss. Notably, the acidomycin BGC is located in proximity to the genes for the biosynthesis of stravidins, secondary metabolites targeting a different enzyme in the biotin biosynthesis pathway, and two genes for streptavidins, proteins that strongly bind and sequester biotin. The identity of the acidomycin BGC was confirmed via both gene knock-out and heterologous expression, which suggested that the fatty acid required for the formation of acidomycin's acyl chain is most likely scavenged from the biotin biosynthesis pathway. CRISPR/Cas9-assisted knock-out of the cytochrome P450-encoding gene in the acidomycin BGC resulted in a significant decrease in its yield but did not abrogate the biosynthesis completely.","lang":"eng"}],"file":[{"content_type":"application/pdf","success":1,"date_created":"2026-05-07T08:21:06Z","file_size":575492,"file_id":"21835","checksum":"8c8aa660cef5394167e06f187adbabf0","creator":"dernst","file_name":"2026_MicrobialBiotechnology_Vignolle.pdf","date_updated":"2026-05-07T08:21:06Z","access_level":"open_access","relation":"main_file"}],"month":"04","article_type":"original","pmid":1,"oa_version":"Published Version","article_processing_charge":"Yes","title":"Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin","year":"2026","author":[{"first_name":"Anna","full_name":"Vignolle, Anna","last_name":"Vignolle"},{"full_name":"Zehl, Martin","first_name":"Martin","id":"8e016d5b-5d77-11f0-86d2-96cdb3922a55","last_name":"Zehl","orcid":"0000-0001-9685-0373"},{"last_name":"Garzón","full_name":"Garzón, Jaime Felipe Guerrero","first_name":"Jaime Felipe Guerrero"},{"last_name":"Schneider","full_name":"Schneider, Olha","first_name":"Olha"},{"full_name":"Gafriller, Johannes","first_name":"Johannes","last_name":"Gafriller"},{"first_name":"Ulrike","full_name":"Grienke, Ulrike","last_name":"Grienke"},{"last_name":"Kirkegaard","full_name":"Kirkegaard, Rasmus H.","first_name":"Rasmus H."},{"last_name":"Zotchev","first_name":"Sergey B.","full_name":"Zotchev, Sergey B."}],"OA_place":"publisher","status":"public","date_created":"2026-05-03T22:01:37Z","acknowledgement":"This work was supported by the University of Vienna. The authors thank Anna Fabisikova from the Mass Spectrometry Centre and the team of the NMR Centre (both of the Faculty of Chemistry, University of Vienna and members of the Vienna Life Science Instruments) for assistance with data acquisition. Open Access funding provided by Universitat Wien. This work was supported by Universität Wien.","publication_status":"published","publisher":"Wiley","issue":"4","date_published":"2026-04-01T00:00:00Z","language":[{"iso":"eng"}],"scopus_import":"1","type":"journal_article","day":"01","ddc":["570"]},{"date_updated":"2026-05-11T06:07:32Z","oa":1,"month":"04","article_type":"original","abstract":[{"text":"Despite the success of mRNA therapeutics, challenges remain in optimizing immune responses and minimizing side effects. Cell-specific antigen delivery may help reduce required doses and improve vaccine efficacy. In this study, we report on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific glycomimetic ligand, we achieve selective mRNA delivery to both murine and human primary Langerhans cells with minimal off-target uptake, at the same time resulting in significantly increased mRNA translation. This targeted mRNA delivery not only enhances antigen presentation and T-cell responses but also enables dose-sparing and superior antitumor immunity compared with conventional immunization in a B16-OVA tumor model. Importantly, our platform’s high compatibility with various lipid nanoparticle formulations offers a flexible and precise tool for skin-directed mRNA delivery.","lang":"eng"}],"_id":"21848","publication":"Journal of Investigative Dermatology","department":[{"_id":"PreCl"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.06.25.661517"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Klein, Klara, et al. “Langerhans Cell–Targeted MRNA Delivery: A Strategy for Dose-Sparing and Enhanced Antitumor Immunity.” Journal of Investigative Dermatology, Elsevier, doi:10.1016/j.jid.2026.03.026.","apa":"Klein, K., Johnson, L., Rîca, R., Sarcevic, M., Carta, G., Seiser, S., … Sparber, F. (n.d.). Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity. Journal of Investigative Dermatology. Elsevier. https://doi.org/10.1016/j.jid.2026.03.026","ista":"Klein K, Johnson L, Rîca R, Sarcevic M, Carta G, Seiser S, Elbe-Bürger A, Langer F, Rahhal N, Rademacher C, Wawrzinek R, Quattrone F, Sparber F. Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity. Journal of Investigative Dermatology.","chicago":"Klein, Klara, Litty Johnson, Ramona Rîca, Mirza Sarcevic, Gabriele Carta, Saskia Seiser, Adelheid Elbe-Bürger, et al. “Langerhans Cell–Targeted MRNA Delivery: A Strategy for Dose-Sparing and Enhanced Antitumor Immunity.” Journal of Investigative Dermatology. Elsevier, n.d. https://doi.org/10.1016/j.jid.2026.03.026.","ieee":"K. Klein et al., “Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity,” Journal of Investigative Dermatology. Elsevier.","short":"K. Klein, L. Johnson, R. Rîca, M. Sarcevic, G. Carta, S. Seiser, A. Elbe-Bürger, F. Langer, N. Rahhal, C. Rademacher, R. Wawrzinek, F. Quattrone, F. Sparber, Journal of Investigative Dermatology (n.d.).","ama":"Klein K, Johnson L, Rîca R, et al. Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity. Journal of Investigative Dermatology. doi:10.1016/j.jid.2026.03.026"},"OA_type":"green","doi":"10.1016/j.jid.2026.03.026","acknowledged_ssus":[{"_id":"PreCl"}],"publication_identifier":{"eissn":["1523-1747"],"issn":["0022-202X"]},"date_published":"2026-04-07T00:00:00Z","day":"07","type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}],"OA_place":"repository","author":[{"first_name":"Klara","full_name":"Klein, Klara","last_name":"Klein"},{"last_name":"Johnson","first_name":"Litty","full_name":"Johnson, Litty"},{"last_name":"Rîca","first_name":"Ramona","full_name":"Rîca, Ramona"},{"last_name":"Sarcevic","first_name":"Mirza","full_name":"Sarcevic, Mirza"},{"last_name":"Carta","first_name":"Gabriele","full_name":"Carta, Gabriele"},{"full_name":"Seiser, Saskia","first_name":"Saskia","last_name":"Seiser"},{"full_name":"Elbe-Bürger, Adelheid","first_name":"Adelheid","last_name":"Elbe-Bürger"},{"first_name":"Freyja","full_name":"Langer, Freyja","id":"3C1BE782-F248-11E8-B48F-1D18A9856A87","last_name":"Langer"},{"last_name":"Rahhal","first_name":"Nowras","full_name":"Rahhal, Nowras"},{"last_name":"Rademacher","first_name":"Christoph","full_name":"Rademacher, Christoph"},{"last_name":"Wawrzinek","first_name":"Robert","full_name":"Wawrzinek, Robert"},{"last_name":"Quattrone","full_name":"Quattrone, Federica","first_name":"Federica"},{"first_name":"Florian","full_name":"Sparber, Florian","last_name":"Sparber"}],"year":"2026","article_processing_charge":"No","title":"Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity","oa_version":"Preprint","publisher":"Elsevier","publication_status":"inpress","acknowledgement":"We thank Mareike Rentzsch for her intellectual contributions during the course of our discussions. We thank Michael Schunn from the Preclinical Facility of the Institute of Science and Technology Austria for his continuous technical support. Guarantor of the work is FS. This project was supported by “Seedfinancing” (P2282679) of the Austrian Federal Ministry of Digital and Economic Affairs and the Ministry of Climate Action and Energy, handled by the Austrian Wirtschaftsservice, as well as by...","status":"public","date_created":"2026-05-10T22:02:16Z"},{"month":"04","article_type":"original","file":[{"success":1,"date_created":"2026-05-12T06:27:54Z","file_size":1957057,"content_type":"application/pdf","file_id":"21861","checksum":"8db35c97588c2f6ef88c7e8d5924cf8c","creator":"dernst","file_name":"2026_JourCellScience_Goeschl.pdf","date_updated":"2026-05-12T06:27:54Z","access_level":"open_access","relation":"main_file"}],"abstract":[{"lang":"eng","text":"Glutamate excitotoxicity is a cell death mechanism triggered by accumulation of glutamate in the extracellular space. The α-ketoglutarate dehydrogenase complex (αKGDHC), an enzyme of the tricarboxylic acid cycle, represents a branching point controlling glutamate formation and its consumption as a fuel. Hence, modulation of the activity of αKGDHC might alter the amount of glutamate available for excitotoxic effects. To address this hypothesis, hippocampal neurons in primary co-culture with glial cells were exposed to zero-Mg2 buffer to elicit excitotoxicity through N-methyl-D-aspartic acid (NMDA) receptor disinhibition. Pretreatment of the cultures with succinyl phosphonate, to inhibit αKGDHC, enhanced excitotoxity, whereas promotion of αKGDHC activity by pretreatment with thiamine caused an opposite action. Moreover, NMDA receptor currents – but not those mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors – were potentiated in neurons with impaired αKGDHC activity and diminished in neurons with boosted αKGDHC activity. The sensitization of NMDA receptors involved mGluR1 activation and was accompanied by enhanced neuronal discharge activity, elevated basal cytosolic Ca2+ levels, and augmented Ca2+ responses evoked by glutamate application. These results suggest that mGluR1-mediated potentiation of NMDA receptors contributes to a mechanism by which inhibition of αKGDHC might exacerbate glutamate excitotoxicity."}],"_id":"21860","intvolume":" 139","publication":"Journal of Cell Science","department":[{"_id":"Bio"}],"volume":139,"date_updated":"2026-05-12T06:40:18Z","external_id":{"pmid":["41834724"]},"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","doi":"10.1242/jcs.264420","publication_identifier":{"issn":["0021-9533"],"eissn":["1477-9137"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"jcs264420","citation":{"short":"V. Goeschl, M. Hotka, B. Hochreiter, K. Hilber, S. Boehm, A.V. Kozlov, H. Kubista, Journal of Cell Science 139 (2026).","ama":"Goeschl V, Hotka M, Hochreiter B, et al. α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures. Journal of Cell Science. 2026;139(8). doi:10.1242/jcs.264420","ista":"Goeschl V, Hotka M, Hochreiter B, Hilber K, Boehm S, Kozlov AV, Kubista H. 2026. α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures. Journal of Cell Science. 139(8), jcs264420.","mla":"Goeschl, Vanessa, et al. “α-Ketoglutarate Dehydrogenase Complex Activity Modulates Glutamate Excitotoxicity via Metabotropic Regulation of NMDA Receptors in Primary Cultures.” Journal of Cell Science, vol. 139, no. 8, jcs264420, The Company of Biologists, 2026, doi:10.1242/jcs.264420.","apa":"Goeschl, V., Hotka, M., Hochreiter, B., Hilber, K., Boehm, S., Kozlov, A. V., & Kubista, H. (2026). α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures. Journal of Cell Science. The Company of Biologists. https://doi.org/10.1242/jcs.264420","chicago":"Goeschl, Vanessa, Matej Hotka, Bernhard Hochreiter, Karlheinz Hilber, Stefan Boehm, Andrey V. Kozlov, and Helmut Kubista. “α-Ketoglutarate Dehydrogenase Complex Activity Modulates Glutamate Excitotoxicity via Metabotropic Regulation of NMDA Receptors in Primary Cultures.” Journal of Cell Science. The Company of Biologists, 2026. https://doi.org/10.1242/jcs.264420.","ieee":"V. Goeschl et al., “α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures,” Journal of Cell Science, vol. 139, no. 8. The Company of Biologists, 2026."},"file_date_updated":"2026-05-12T06:27:54Z","quality_controlled":"1","OA_type":"hybrid","PlanS_conform":"1","ddc":["570"],"day":"27","type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}],"date_published":"2026-04-27T00:00:00Z","issue":"8","publisher":"The Company of Biologists","publication_status":"published","acknowledgement":"The technical assistance by Tanja Wagner and Elena Lilliu is gratefully acknowledged. This research was funded in whole or in part by the Austrian Science Fund (FWF) (P36145 to H.K., PAT8605623 to M.H. and P33799 to A.V.K.]. Open Access funding provided by Medical University of Vienna and the Austrian Science Fund (FWF). Deposited in PMC for immediate release.","date_created":"2026-05-11T10:52:27Z","status":"public","OA_place":"publisher","author":[{"last_name":"Goeschl","first_name":"Vanessa","full_name":"Goeschl, Vanessa"},{"last_name":"Hotka","first_name":"Matej","full_name":"Hotka, Matej"},{"last_name":"Hochreiter","id":"e6cab3de-17f6-11ed-9210-c1e42e045e9d","full_name":"Hochreiter, Bernhard","first_name":"Bernhard"},{"full_name":"Hilber, Karlheinz","first_name":"Karlheinz","last_name":"Hilber"},{"last_name":"Boehm","full_name":"Boehm, Stefan","first_name":"Stefan"},{"first_name":"Andrey V.","full_name":"Kozlov, Andrey V.","last_name":"Kozlov"},{"last_name":"Kubista","first_name":"Helmut","full_name":"Kubista, Helmut"}],"year":"2026","article_processing_charge":"Yes (via OA deal)","title":"α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures","oa_version":"Published Version","pmid":1},{"external_id":{"pmid":["42104760"]},"date_updated":"2026-05-18T08:55:42Z","corr_author":"1","oa":1,"article_type":"original","month":"05","_id":"21883","abstract":[{"lang":"eng","text":"Three-dimensional (3D) printing has rapidly developed from a niche hobbyist activity into a widely accessible and indispensable technology across multiple scientific disciplines. Within microscopy, optical engineering laboratories and imaging core facilities, 3D printing enables creating customised solutions for sample holders, optical components and everyday laboratory tools that traditionally required specialised machining. By providing rapid prototyping, low-cost production and reproducibility, 3D printing facilitates innovation and efficiency in facility operations. This article provides a perspective on the possibilities, challenges, and practical aspects of implementing 3D printing within microscopy core facilities. Instead of providing technical review about 3D printing, we focus on service organisation, user engagement, resource management and community-driven repositories for design dissemination. Our aim is to share insights with those considering the implementation of 3D printing as a service for developing add-on components to ease the operation of different aspects of the machine-park driven services and those who are managing advanced instrumentation within research groups."}],"department":[{"_id":"Bio"}],"publication":"Journal of Microscopy","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.1111/jmi.70106","open_access":"1"}],"citation":{"chicago":"Goudarzi, Mohammad, Maximilian Schuster, Arthur Milberger, Manuel Gunkel, Stefan Terjung, and Gabriel Krens. “3D Printing in Core Facilities – Low Pain, High Gain.” Journal of Microscopy. Wiley, 2026. https://doi.org/10.1111/jmi.70106.","apa":"Goudarzi, M., Schuster, M., Milberger, A., Gunkel, M., Terjung, S., & Krens, G. (2026). 3D printing in core facilities – Low pain, high gain. Journal of Microscopy. Wiley. https://doi.org/10.1111/jmi.70106","mla":"Goudarzi, Mohammad, et al. “3D Printing in Core Facilities – Low Pain, High Gain.” Journal of Microscopy, Wiley, 2026, doi:10.1111/jmi.70106.","ista":"Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 2026. 3D printing in core facilities – Low pain, high gain. Journal of Microscopy.","ieee":"M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, and G. Krens, “3D printing in core facilities – Low pain, high gain,” Journal of Microscopy. Wiley, 2026.","short":"M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, G. Krens, Journal of Microscopy (2026).","ama":"Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 3D printing in core facilities – Low pain, high gain. Journal of Microscopy. 2026. doi:10.1111/jmi.70106"},"quality_controlled":"1","PlanS_conform":"1","OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1111/jmi.70106","has_accepted_license":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"}],"publication_identifier":{"eissn":["1365-2818"],"issn":["0022-2720"]},"date_published":"2026-05-09T00:00:00Z","type":"journal_article","ddc":["600"],"day":"09","scopus_import":"1","language":[{"iso":"eng"}],"OA_place":"publisher","year":"2026","author":[{"id":"3384113A-F248-11E8-B48F-1D18A9856A87","last_name":"Goudarzi","full_name":"Goudarzi, Mohammad","first_name":"Mohammad"},{"first_name":"Maximilian","full_name":"Schuster, Maximilian","id":"37e65def-d415-11eb-ae59-a7b67be103db","last_name":"Schuster"},{"last_name":"Milberger","full_name":"Milberger, Arthur","first_name":"Arthur"},{"first_name":"Manuel","full_name":"Gunkel, Manuel","last_name":"Gunkel"},{"first_name":"Stefan","full_name":"Terjung, Stefan","last_name":"Terjung"},{"full_name":"Krens, Gabriel","first_name":"Gabriel","last_name":"Krens","id":"2B819732-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4761-5996"}],"oa_version":"Published Version","title":"3D printing in core facilities – Low pain, high gain","article_processing_charge":"Yes (via OA deal)","pmid":1,"publisher":"Wiley","publication_status":"epub_ahead","date_created":"2026-05-17T22:02:11Z","status":"public","acknowledgement":"This work was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Imaging & Optics Facility (IOF) and the MiBa Machine Shop. Specifically; Robert Hauschild (IOF), sharing designs, insights and pioneering 3D printing activities at the Imaging and Optics Facility; Bernhard Hochreiter (IOF), for support and testing of anoxic chamber. We also thank Ana Rita Carvalho Faria and Oliver Biehlmaier (Biozentrum University of Basel, Imaging Core Facility) for sharing the design of the adopted power meter.\r\nOpen Access funding provided by Institute of Science and Technology Austria."},{"corr_author":"1","oa":1,"external_id":{"isi":["001329812000001"]},"date_updated":"2025-12-30T06:55:59Z","volume":137,"department":[{"_id":"PreCl"}],"publication":"Wiener Klinische Wochenschrift","abstract":[{"lang":"eng","text":"Research involving human subjects or identifiable human material and data must be assessed by an ethics committee. The Karl Landsteiner University of Health Sciences has established a Commission on Ethics and Scientific Integrity to evaluate medical research conducted by its faculty and students and at its affiliated hospitals.\r\nAll projects submitted to the Commission on Ethics and Scientific Integrity between 2018 and 2023 were analyzed regarding their major characteristics, the duration of the evaluation process, and votes issued.\r\nA total of 520 applications were electronically submitted during the observation period. Most of the studies were retrospective data analyses in the field of oncology, psychology and surgery. Most studies included less than 100 volunteers. Of the applications 50% received a final vote within 5 months, during which several revision rounds took place. Overall, about 77% of votes issued during the observation period were positive and 2% were rejections. In 11% files were closed due to withdrawal. In 11% final votes were pending at the end of the observation period due to requests for revisions.\r\nOur results emphasize the importance of institutional ethics committees using the example of the Commission on Ethics and Scientific Integrity at the Karl Landsteiner University. Such committees fill a gap in evaluating research not covered by Austrian legal regulations. Continuous development of standards, operating procedures, and national and international collaborations are required to assess and minimize risks to trial subjects and to provide a safe and productive environment for research in human medicine and related fields."}],"_id":"18449","intvolume":" 137","file":[{"relation":"main_file","access_level":"open_access","date_updated":"2025-12-30T06:54:03Z","file_name":"2025_WrKlinischeWochenschrift_Schober.pdf","creator":"dernst","checksum":"321be8a584117feaea9f3feaa28caabd","file_id":"20880","content_type":"application/pdf","success":1,"date_created":"2025-12-30T06:54:03Z","file_size":580791}],"article_type":"original","month":"07","PlanS_conform":"1","OA_type":"hybrid","quality_controlled":"1","citation":{"ieee":"S. Schober, S. Klee, and F. Trautinger, “The role of institutional ethics committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023,” Wiener Klinische Wochenschrift, vol. 137. Springer Nature, pp. 432–437, 2025.","ista":"Schober S, Klee S, Trautinger F. 2025. The role of institutional ethics committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023. Wiener Klinische Wochenschrift. 137, 432–437.","apa":"Schober, S., Klee, S., & Trautinger, F. (2025). The role of institutional ethics committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023. Wiener Klinische Wochenschrift. Springer Nature. https://doi.org/10.1007/s00508-024-02462-x","mla":"Schober, Sophie, et al. “The Role of Institutional Ethics Committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023.” Wiener Klinische Wochenschrift, vol. 137, Springer Nature, 2025, pp. 432–37, doi:10.1007/s00508-024-02462-x.","chicago":"Schober, Sophie, Sascha Klee, and Franz Trautinger. “The Role of Institutional Ethics Committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023.” Wiener Klinische Wochenschrift. Springer Nature, 2025. https://doi.org/10.1007/s00508-024-02462-x.","ama":"Schober S, Klee S, Trautinger F. The role of institutional ethics committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023. Wiener Klinische Wochenschrift. 2025;137:432-437. doi:10.1007/s00508-024-02462-x","short":"S. Schober, S. Klee, F. Trautinger, Wiener Klinische Wochenschrift 137 (2025) 432–437."},"file_date_updated":"2025-12-30T06:54:03Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1613-7671"],"issn":["0043-5325"]},"doi":"10.1007/s00508-024-02462-x","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-07-01T00:00:00Z","language":[{"iso":"eng"}],"isi":1,"scopus_import":"1","type":"journal_article","ddc":["570"],"day":"01","page":"432-437","oa_version":"Published Version","title":"The role of institutional ethics committees in Austria: Report of the Commission on Ethics and Scientific Integrity of the Karl Landsteiner University of Health Sciences 2018–2023","article_processing_charge":"Yes (via OA deal)","year":"2025","author":[{"id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","last_name":"Schober","first_name":"Sophie","full_name":"Schober, Sophie"},{"full_name":"Klee, Sascha","first_name":"Sascha","last_name":"Klee"},{"last_name":"Trautinger","full_name":"Trautinger, Franz","first_name":"Franz"}],"OA_place":"publisher","date_created":"2024-10-20T22:02:07Z","status":"public","acknowledgement":"Open access funding provided by Karl Landsteiner University.","publication_status":"published","publisher":"Springer Nature"},{"month":"03","day":"15","type":"conference","_id":"20055","abstract":[{"text":"Supercrystals represent three-dimensional orderings of colloidal nanocrystals (NCs), showcasing collective properties in photonics, phononics, and electronics applications.1,2 Recent studies have shown that such assemblies are directly produced during nanocrystal reactions.3–6 However, a fundamental understanding of in situ formed supercrystals that withstand typical NC purification processes remains underexplored, which is important for further use. Herein, we report the reaction precursor-mediated formation of stable PbTe supercrystals. Rationalizing the formation of these assemblies through small-angle x-ray scattering (SAXS) measurements, we unveil their formation mechanism. Our findings reveal that the supercrystal formation occurs in the presence of an excess of lead oleates in the crude solution. It should be noted that the formed supercrystals can be stabilized under specific conditions determined by the lead oleate cluster concentration, content of trioctylphosphine telluride (TOP-Te), NC size and the need of an annealing step at mild conditions. Furthermore, this approach allows for the continuous growth of a secondary phase within the supercrystal; for example in the case of PbTe supercrystals, a PbS shell can be grown on each PbTe NC constituent, resulting in core-shell PbTe-PbS supercrystals. Our work elucidates that reaction precursors play an important role in in situ SC formation and stabilization, implying the possibility of applying this knowledge to other NC reactions.","lang":"eng"}],"publication":"Proceedings of the MATSUS Spring 2025 Conference","department":[{"_id":"MaIb"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"date_published":"2025-03-15T00:00:00Z","date_updated":"2026-02-19T09:25:57Z","corr_author":"1","publisher":"Fundació de la comunitat valenciana SCITO","publication_status":"published","doi":"10.29363/nanoge.matsusspring.2025.173","project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"NMR"},{"_id":"LifeSc"}],"acknowledgement":"ISTA and the Werner Siemens Foundation financially supported this work. The Scientific Service Units (SSU) of ISTA supported this research through resources provided by the Electron Microscopy Facility (EMF), NMR Facility and the Lab Support Facility (LSF).","date_created":"2025-07-21T08:33:20Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"173","author":[{"first_name":"Seungho","full_name":"Lee, Seungho","last_name":"Lee","id":"BB243B88-D767-11E9-B658-BC13E6697425","orcid":"0000-0002-6962-8598"},{"orcid":"0000-0001-7597-043X","last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","first_name":"Daniel","full_name":"Balazs, Daniel"},{"last_name":"Horta","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc","full_name":"Horta, Sharona","first_name":"Sharona"},{"first_name":"Aiswarya","full_name":"Rayaroth Puthiyaveettil, Aiswarya","id":"8aceb01b-8972-11ed-ae7b-d5fe53775add","last_name":"Rayaroth Puthiyaveettil"},{"first_name":"Maria","full_name":"Ibáñez, Maria","last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5013-2843"}],"year":"2025","citation":{"ama":"Lee S, Balazs D, Horta S, Rayaroth Puthiyaveettil A, Ibáñez M. Reaction precursor-mediated formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case. In: Proceedings of the MATSUS Spring 2025 Conference. Fundació de la comunitat valenciana SCITO; 2025. doi:10.29363/nanoge.matsusspring.2025.173","short":"S. Lee, D. Balazs, S. Horta, A. Rayaroth Puthiyaveettil, M. Ibáñez, in:, Proceedings of the MATSUS Spring 2025 Conference, Fundació de la comunitat valenciana SCITO, 2025.","ieee":"S. Lee, D. Balazs, S. Horta, A. Rayaroth Puthiyaveettil, and M. Ibáñez, “Reaction precursor-mediated formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case,” in Proceedings of the MATSUS Spring 2025 Conference, Sevilla, Spain, 2025.","chicago":"Lee, Seungho, Daniel Balazs, Sharona Horta, Aiswarya Rayaroth Puthiyaveettil, and Maria Ibáñez. “Reaction Precursor-Mediated Formation of Stable Supercrystals in Colloidal Nanocrystal Synthesis: PbTe Case.” In Proceedings of the MATSUS Spring 2025 Conference. Fundació de la comunitat valenciana SCITO, 2025. https://doi.org/10.29363/nanoge.matsusspring.2025.173.","mla":"Lee, Seungho, et al. “Reaction Precursor-Mediated Formation of Stable Supercrystals in Colloidal Nanocrystal Synthesis: PbTe Case.” Proceedings of the MATSUS Spring 2025 Conference, 173, Fundació de la comunitat valenciana SCITO, 2025, doi:10.29363/nanoge.matsusspring.2025.173.","ista":"Lee S, Balazs D, Horta S, Rayaroth Puthiyaveettil A, Ibáñez M. 2025. Reaction precursor-mediated formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case. Proceedings of the MATSUS Spring 2025 Conference. MATSUS: Materials for Sustainable Development Conference, 173.","apa":"Lee, S., Balazs, D., Horta, S., Rayaroth Puthiyaveettil, A., & Ibáñez, M. (2025). Reaction precursor-mediated formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case. In Proceedings of the MATSUS Spring 2025 Conference. Sevilla, Spain: Fundació de la comunitat valenciana SCITO. https://doi.org/10.29363/nanoge.matsusspring.2025.173"},"quality_controlled":"1","article_processing_charge":"No","title":"Reaction precursor-mediated formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case","oa_version":"None","OA_type":"closed access","conference":{"location":"Sevilla, Spain","start_date":"2025-03-03","name":"MATSUS: Materials for Sustainable Development Conference","end_date":"2025-03-07"}},{"author":[{"full_name":"Gredler, Paul","first_name":"Paul","last_name":"Gredler"},{"last_name":"Kaier","first_name":"Christian","full_name":"Kaier, Christian"},{"last_name":"Danowski","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","full_name":"Danowski, Patrick","first_name":"Patrick","orcid":"0000-0002-6026-4409"},{"last_name":"Zoyer","full_name":"Zoyer, Michael","first_name":"Michael"},{"first_name":"Katharina","full_name":"Rieck, Katharina","last_name":"Rieck"},{"last_name":"Ferus","full_name":"Ferus, Andreas","first_name":"Andreas"},{"full_name":"Rosenberger, Elisabeth","first_name":"Elisabeth","last_name":"Rosenberger"},{"first_name":"Alexander","full_name":"Löffler, Alexander","last_name":"Löffler"},{"last_name":"Hofer","full_name":"Hofer, Lisa","first_name":"Lisa"},{"first_name":"Laura","full_name":"Still, Laura","last_name":"Still"}],"year":"2025","citation":{"ama":"Gredler P, Kaier C, Danowski P, et al. Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures. Zenodo; 2025. doi:10.5281/zenodo.15269364","short":"P. Gredler, C. Kaier, P. Danowski, M. Zoyer, K. Rieck, A. Ferus, E. Rosenberger, A. Löffler, L. Hofer, L. Still, Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures, Zenodo, 2025.","ieee":"P. Gredler et al., Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures. Zenodo, 2025.","chicago":"Gredler, Paul, Christian Kaier, Patrick Danowski, Michael Zoyer, Katharina Rieck, Andreas Ferus, Elisabeth Rosenberger, Alexander Löffler, Lisa Hofer, and Laura Still. Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures. Zenodo, 2025. https://doi.org/10.5281/zenodo.15269364.","ista":"Gredler P, Kaier C, Danowski P, Zoyer M, Rieck K, Ferus A, Rosenberger E, Löffler A, Hofer L, Still L. 2025. Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures, Zenodo,p.","apa":"Gredler, P., Kaier, C., Danowski, P., Zoyer, M., Rieck, K., Ferus, A., … Still, L. (2025). Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures. Zenodo. https://doi.org/10.5281/zenodo.15269364","mla":"Gredler, Paul, et al. Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures. Zenodo, 2025, doi:10.5281/zenodo.15269364."},"main_file_link":[{"url":"https://doi.org/10.5281/zenodo.15269364","open_access":"1"}],"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"gold","article_processing_charge":"No","title":"Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures","oa_version":"Published Version","has_accepted_license":"1","doi":"10.5281/zenodo.15269364","publication_status":"published","publisher":"Zenodo","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","date_created":"2025-08-07T11:10:14Z","date_updated":"2025-08-11T07:20:03Z","date_published":"2025-08-07T00:00:00Z","oa":1,"day":"07","ddc":["020"],"_id":"20146","abstract":[{"text":"This criteria catalogue and the accompanying assessment questions were developed by a working group of KEMÖ (Kooperation E-Medien Österreich, the Austrian Academic Library Consortium). They are intended to support research institutions and organisations in the evaluation of Open Science Infrastructures. The 20 criteria outlined in the catalogue provide a structured basis for making informed decisions regarding the financial support of these infrastructures.\r\n\r\nThe assessment questions are intended to be completed by Open Science Infrastructures and can be shared with them accordingly.","lang":"eng"}],"type":"working_paper","month":"08","language":[{"iso":"eng"}],"department":[{"_id":"E-Lib"}]},{"date_published":"2025-10-01T00:00:00Z","issue":"19","type":"journal_article","ddc":["530"],"day":"01","language":[{"iso":"eng"}],"isi":1,"scopus_import":"1","year":"2025","author":[{"full_name":"Lenton, Isaac C","first_name":"Isaac C","last_name":"Lenton","id":"a550210f-223c-11ec-8182-e2d45e817efb","orcid":"0000-0002-5010-6984"},{"last_name":"Pertl","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","first_name":"Felix","full_name":"Pertl, Felix","orcid":"0000-0003-0463-5794"},{"orcid":"0000-0001-7180-6050","first_name":"Lubuna B","full_name":"Shafeek, Lubuna B","last_name":"Shafeek","id":"3CD37A82-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-2299-3176","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","last_name":"Waitukaitis","first_name":"Scott R","full_name":"Waitukaitis, Scott R"}],"OA_place":"publisher","arxiv":1,"ec_funded":1,"oa_version":"Published Version","article_processing_charge":"Yes","title":"A duality between surface charge and work function in scanning Kelvin probe microscopy","publication_status":"published","publisher":"Wiley","date_created":"2025-09-07T22:01:33Z","status":"public","acknowledgement":"This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 949120). This research was supported by the Scientific Service Units of The Institute of Science and Technology Austria (ISTA) through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing Facility, and Lab Support Facility. The authors wish to thank Dmytro Rak and Juan Carlos Sobarzo for letting us use their equipment. The authors wish to thank Evgeniia Volobueva for advice in preparing PFIB samples. The authors wish to thank the contributions of the whole Waitukaitis group for useful discussions and feedback.","project":[{"name":"Tribocharge: a multi-scale approach to an enduring problem in physics","grant_number":"949120","call_identifier":"H2020","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa"}],"external_id":{"arxiv":["2506.07187"],"isi":["001560163400001"]},"date_updated":"2025-12-30T09:31:25Z","corr_author":"1","oa":1,"intvolume":" 12","_id":"20295","abstract":[{"text":"Scanning Kelvin probe microscopy (SKPM) is a powerful technique for macroscopic imaging of the electrostatic potential above a surface. Though most often used to image work-function variations of conductive surfaces, it can also be used to probe the surface charge on insulating surfaces. In both cases, relating the measured potential to the underlying signal is non-trivial. Here, general relationships are derived between the measured SKPM voltage and the underlying source, revealing either can be cast as a convolution with an appropriately scaled point spread function (PSF). For charge that exists on a thin insulating layer above a conductor, the PSF has the same shape as what would occur from a work-function variation alone, differing by a simple scaling factor. This relationship is confirmed by: (1) backing it out from finite-element simulations of work-function and charge signals, and (2) experimentally comparing the measured PSF from a small work-function target to that from a small charge spot. This scaling factor is further validated by comparing SKPM charge measurements with Faraday cup measurements for highly charged samples from contact-charging experiments. These results highlight a heretofore unappreciated connection between SKPM voltage and charge signals, offering a rigorous recipe to extract either from experimental data.","lang":"eng"}],"file":[{"creator":"dernst","checksum":"906fcc7733be8ce8a83600427b82cd5a","file_id":"20908","content_type":"application/pdf","file_size":1830117,"date_created":"2025-12-30T09:31:11Z","success":1,"relation":"main_file","access_level":"open_access","date_updated":"2025-12-30T09:31:11Z","file_name":"2025_AdvMaterialsInterfaces_Lenton.pdf"}],"article_type":"original","month":"10","volume":12,"DOAJ_listed":"1","department":[{"_id":"ScWa"},{"_id":"NanoFab"}],"publication":"Advanced Materials Interfaces","file_date_updated":"2025-12-30T09:31:11Z","citation":{"short":"I.C. Lenton, F. Pertl, L.B. Shafeek, S.R. Waitukaitis, Advanced Materials Interfaces 12 (2025).","ama":"Lenton IC, Pertl F, Shafeek LB, Waitukaitis SR. A duality between surface charge and work function in scanning Kelvin probe microscopy. Advanced Materials Interfaces. 2025;12(19). doi:10.1002/admi.202500521","chicago":"Lenton, Isaac C, Felix Pertl, Lubuna B Shafeek, and Scott R Waitukaitis. “A Duality between Surface Charge and Work Function in Scanning Kelvin Probe Microscopy.” Advanced Materials Interfaces. Wiley, 2025. https://doi.org/10.1002/admi.202500521.","mla":"Lenton, Isaac C., et al. “A Duality between Surface Charge and Work Function in Scanning Kelvin Probe Microscopy.” Advanced Materials Interfaces, vol. 12, no. 19, e00521, Wiley, 2025, doi:10.1002/admi.202500521.","ista":"Lenton IC, Pertl F, Shafeek LB, Waitukaitis SR. 2025. A duality between surface charge and work function in scanning Kelvin probe microscopy. Advanced Materials Interfaces. 12(19), e00521.","apa":"Lenton, I. C., Pertl, F., Shafeek, L. B., & Waitukaitis, S. R. (2025). A duality between surface charge and work function in scanning Kelvin probe microscopy. Advanced Materials Interfaces. Wiley. https://doi.org/10.1002/admi.202500521","ieee":"I. C. Lenton, F. Pertl, L. B. Shafeek, and S. R. Waitukaitis, “A duality between surface charge and work function in scanning Kelvin probe microscopy,” Advanced Materials Interfaces, vol. 12, no. 19. Wiley, 2025."},"article_number":"e00521","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","PlanS_conform":"1","OA_type":"gold","quality_controlled":"1","doi":"10.1002/admi.202500521","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2196-7350"]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"LifeSc"}]},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2025-09-10T07:53:10Z","citation":{"chicago":"Tatman, Benjamin, Vidhyalakshmi Sridharan, Motilal Uttarkabat, Christopher P. Jaroniec, Matthias Ernst, Petra Rovo, and Paul Schanda. “Bumps on the Road: The Way to Clean Relaxation Dispersion Magic-Angle Spinning NMR.” Journal of the American Chemical Society. American Chemical Society, 2025. https://doi.org/10.1021/jacs.5c09057.","apa":"Tatman, B., Sridharan, V., Uttarkabat, M., Jaroniec, C. P., Ernst, M., Rovo, P., & Schanda, P. (2025). Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.5c09057","mla":"Tatman, Benjamin, et al. “Bumps on the Road: The Way to Clean Relaxation Dispersion Magic-Angle Spinning NMR.” Journal of the American Chemical Society, vol. 147, no. 32, American Chemical Society, 2025, pp. 29315–26, doi:10.1021/jacs.5c09057.","ista":"Tatman B, Sridharan V, Uttarkabat M, Jaroniec CP, Ernst M, Rovo P, Schanda P. 2025. Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. 147(32), 29315–29326.","ieee":"B. Tatman et al., “Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR,” Journal of the American Chemical Society, vol. 147, no. 32. American Chemical Society, pp. 29315–29326, 2025.","short":"B. Tatman, V. Sridharan, M. Uttarkabat, C.P. Jaroniec, M. Ernst, P. Rovo, P. Schanda, Journal of the American Chemical Society 147 (2025) 29315–29326.","ama":"Tatman B, Sridharan V, Uttarkabat M, et al. Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. 2025;147(32):29315-29326. doi:10.1021/jacs.5c09057"},"quality_controlled":"1","OA_type":"hybrid","PlanS_conform":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","doi":"10.1021/jacs.5c09057","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"related_material":{"record":[{"id":"19696","relation":"used_in_publication","status":"public"}]},"date_updated":"2026-01-28T12:36:30Z","external_id":{"pmid":["40748291"],"isi":["001542746200001"]},"corr_author":"1","oa":1,"article_type":"original","month":"08","file":[{"date_created":"2025-09-10T07:53:10Z","success":1,"file_size":5235353,"content_type":"application/pdf","file_id":"20337","checksum":"b350d56ddddefea96cebd62c277c0ff5","creator":"dernst","file_name":"2025_JACS_Tatman.pdf","access_level":"open_access","date_updated":"2025-09-10T07:53:10Z","relation":"main_file"}],"_id":"20321","intvolume":" 147","abstract":[{"text":"Microsecond-to-millisecond motions are instrumental for many biomolecular functions, including enzymatic activity and ligand binding. Bloch-McConnell Relaxation Dispersion (BMRD) Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for studying these dynamic processes. While BMRD experiments are routinely used to probe protein motions in solution, the experiment is more demanding in the solid state, where dipolar couplings complicate the spin dynamics. It is believed that high deuteration levels are required and sufficient to obtain accurate and quantitative data. Here we show that even under fast magic-angle spinning and high levels of deuteration artifactual “bumps” in 15N R1ρ BMRD profiles are common. The origin of these artifacts is identified as a second-order three-spin Mixed Rotational and Rotary Resonance (MIRROR) recoupling condition. These artifacts are found to be a significant confounding factor for the accurate quantification of microsecond protein dynamics using BMRD in the solid state. We show that the application of low-power continuous wave (CW) decoupling simultaneously with the 15N spin-lock leads to the suppression of these conditions and enables quantitative measurements of microsecond exchange in the solid state. Remarkably, the application of decoupling allows the measurement of accurate BMRD even in fully protonated proteins at 100 kHz MAS, thus extending the scope of μs dynamics measurements in MAS NMR.","lang":"eng"}],"publication":"Journal of the American Chemical Society","department":[{"_id":"PaSc"},{"_id":"NMR"}],"volume":147,"OA_place":"publisher","author":[{"last_name":"Tatman","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","first_name":"Benjamin","full_name":"Tatman, Benjamin"},{"full_name":"Sridharan, Vidhyalakshmi","first_name":"Vidhyalakshmi","last_name":"Sridharan"},{"full_name":"Uttarkabat, Motilal","first_name":"Motilal","last_name":"Uttarkabat"},{"last_name":"Jaroniec","full_name":"Jaroniec, Christopher P.","first_name":"Christopher P."},{"last_name":"Ernst","first_name":"Matthias","full_name":"Ernst, Matthias"},{"last_name":"Rovo","id":"c316e53f-b965-11eb-b128-bb26acc59c00","full_name":"Rovo, Petra","first_name":"Petra","orcid":"0000-0001-8729-7326"},{"last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","first_name":"Paul","orcid":"0000-0002-9350-7606"}],"year":"2025","title":"Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","pmid":1,"publisher":"American Chemical Society","publication_status":"published","acknowledgement":"The authors thank Alexey Krushelnitsky for useful discussions. C.P.J. thanks NSF (MCB-2303862) and NIH (R35GM156238 and S10OD012303) for funding. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities.","status":"public","date_created":"2025-09-10T05:37:19Z","date_published":"2025-08-01T00:00:00Z","issue":"32","ddc":["540"],"page":"29315-29326","day":"01","type":"journal_article","scopus_import":"1","isi":1,"language":[{"iso":"eng"}]},{"oa":1,"corr_author":"1","date_updated":"2025-09-30T10:40:49Z","related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/high-tech-video-optimization-in-our-brain/","description":"News on ISTA Website"}],"record":[{"status":"public","relation":"research_data","id":"18579"}]},"external_id":{"pmid":["39930095"],"isi":["001416866800001"]},"volume":28,"publication":"Nature Neuroscience","department":[{"_id":"MaJö"},{"_id":"PreCl"}],"_id":"19076","abstract":[{"text":"For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external stimuli and those elicited by its own actions. The diversity of behaviors and their complex influences on the senses make this distinction challenging. Here, we uncover an action–cue hub that coordinates motor commands with visual processing in the brain’s first visual relay. We show that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge center, integrating visual translational optic flow signals with motor copies from saccades, locomotion and pupil dynamics. The vLGN relays these signals to correct action-specific visual distortions and to refine perception, as shown for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide vLGN projections drive corrective actions necessary for accurate visuomotor control. Our results reveal an extended corollary discharge architecture that refines early visual transformations and coordinates actions via a distributed hub-and-spoke network to enable visual perception during action.","lang":"eng"}],"intvolume":" 28","month":"03","article_type":"original","OA_type":"hybrid","quality_controlled":"1","article_number":"7278","citation":{"ista":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2025. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. 28, 7278.","apa":"Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., & Jösch, M. A. (2025). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/s41593-025-01874-w","mla":"Vega Zuniga, Tomas A., et al. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Nature Neuroscience, vol. 28, 7278, Springer Nature, 2025, doi:10.1038/s41593-025-01874-w.","chicago":"Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Nature Neuroscience. Springer Nature, 2025. https://doi.org/10.1038/s41593-025-01874-w.","ieee":"T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics,” Nature Neuroscience, vol. 28. Springer Nature, 2025.","short":"T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, M.A. Jösch, Nature Neuroscience 28 (2025).","ama":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. 2025;28. doi:10.1038/s41593-025-01874-w"},"main_file_link":[{"url":"https://doi.org/10.1038/s41593-025-01874-w","open_access":"1"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"eissn":["1546-1726"],"issn":["1097-6256"]},"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"Bio"}],"has_accepted_license":"1","doi":"10.1038/s41593-025-01874-w","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-03-01T00:00:00Z","isi":1,"language":[{"iso":"eng"}],"scopus_import":"1","day":"01","type":"journal_article","pmid":1,"title":"A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","ec_funded":1,"author":[{"last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","first_name":"Tomas A","full_name":"Vega Zuniga, Tomas A"},{"first_name":"Anton L","full_name":"Sumser, Anton L","last_name":"Sumser","id":"3320A096-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4792-1881"},{"orcid":"0000-0003-2012-9947","full_name":"Symonova, Olga","first_name":"Olga","last_name":"Symonova","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Peter","full_name":"Koppensteiner, Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","last_name":"Koppensteiner","orcid":"0000-0002-3509-1948"},{"id":"A2EF226A-AF19-11E9-924C-0525E6697425","last_name":"Schmidt","full_name":"Schmidt, Florian","first_name":"Florian"},{"orcid":"0000-0002-3937-1330","full_name":"Jösch, Maximilian A","first_name":"Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","last_name":"Jösch"}],"year":"2025","OA_place":"publisher","acknowledgement":"We thank Y. Ben-Simon for generously making viral vectors for retrograde tracing available, as well as J. Watson and F. Marr for reagents. We also thank R. Shigemoto, W. Młynarski and members of the Neuroethology group for their comments on the manuscript and L. Burnett for her schematic drawings. This research was supported by the Scientific Service Units of ISTA through resources provided by Scientific Computing, the Preclinical Facility, the Lab Support Facility and the Imaging and Optics Facility, in particular F. Lange, M. Schunn and T. Asenov. This work was supported by European Research Council Starting Grant no. 756502 (M.J.) and European Research Council Consolidator Grant no. 101086580 (M.J.); and EMBO ALTF grant no. 1098-2017 (A.S.) and Human Frontiers Science Program grant no. LT000256/2018-L (A.S.). Open access funding provided by Institute of Science and Technology (IST Austria).","status":"public","date_created":"2025-02-23T23:01:58Z","project":[{"_id":"2634E9D2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Circuits of Visual Attention","grant_number":"756502"},{"_id":"bdaf81a8-d553-11ed-ba76-c95961984540","name":"Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses","grant_number":"101086580"},{"name":"Connecting sensory with motor processing in the superior colliculus","grant_number":"ALTF 1098-2017","_id":"264FEA02-B435-11E9-9278-68D0E5697425"},{"grant_number":"LT000256","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus","_id":"266D407A-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","publisher":"Springer Nature"},{"publication_status":"published","publisher":"Elsevier","acknowledgement":"We are grateful to the colleagues who contributed to this work with discussions, technical advice, and feedback on the manuscript: Irene Steccari, David Labrousse Arias and the other members of the Heisenberg lab, Nicole Amberg, Florian Pauler, Nicoletta Petridou, Elena Scarpa, and Edouard Hannezo. We also thank the Imaging and Optics Facility, the Life Science Facility, and the Scientific Computing Unit at ISTA for support. The Next Generation Sequencing Facility at Vienna BioCenter Core Facilities performed the RNA-seq for animal and lateral ectoderm. D.B.B. was supported by the NOMIS Foundation as a NOMIS Fellow and by an EMBO Postdoctoral Fellowship (ALTF 343-2022). S. Tavano was supported by an EMBO Postdoctoral Fellowship (ALTF 1159-2018).","status":"public","date_created":"2025-03-16T23:01:24Z","project":[{"name":"A mechano-chemical theory for stem cell fate decisions in organoid development","grant_number":"ALTF 343-2022","_id":"34e2a5b5-11ca-11ed-8bc3-b2265616ef0b"},{"name":"Mechanosensation in cell migration: the role of friction forces in cell polarization and directed migration","grant_number":"ALTF 1159-2018","_id":"269CD5C4-B435-11E9-9278-68D0E5697425"}],"author":[{"first_name":"Ste","full_name":"Tavano, Ste","id":"2F162F0C-F248-11E8-B48F-1D18A9856A87","last_name":"Tavano","orcid":"0000-0001-9970-7804"},{"last_name":"Brückner","id":"e1e86031-6537-11eb-953a-f7ab92be508d","first_name":"David","full_name":"Brückner, David","orcid":"0000-0001-7205-2975"},{"first_name":"Saren","full_name":"Tasciyan, Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","last_name":"Tasciyan","orcid":"0000-0003-1671-393X"},{"id":"50F65CDC-AA30-11E9-A72B-8A12E6697425","last_name":"Tong","first_name":"Xin","full_name":"Tong, Xin"},{"first_name":"Roland","full_name":"Kardos, Roland","last_name":"Kardos","id":"4039350E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schauer","id":"30A536BA-F248-11E8-B48F-1D18A9856A87","first_name":"Alexandra","full_name":"Schauer, Alexandra","orcid":"0000-0001-7659-9142"},{"orcid":"0000-0001-9843-3522","first_name":"Robert","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"}],"year":"2025","OA_place":"publisher","pmid":1,"article_processing_charge":"Yes","title":"BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation","oa_version":"Published Version","ddc":["570"],"day":"25","type":"journal_article","isi":1,"language":[{"iso":"eng"}],"scopus_import":"1","date_published":"2025-03-25T00:00:00Z","issue":"3","has_accepted_license":"1","doi":"10.1016/j.celrep.2025.115387","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)"},"publication_identifier":{"eissn":["2211-1247"],"issn":["2639-1856"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"article_number":"115387","citation":{"apa":"Tavano, S., Brückner, D., Tasciyan, S., Tong, X., Kardos, R., Schauer, A., … Heisenberg, C.-P. J. (2025). BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2025.115387","mla":"Tavano, Ste, et al. “BMP-Dependent Patterning of Ectoderm Tissue Material Properties Modulates Lateral Mesendoderm Cell Migration during Early Zebrafish Gastrulation.” Cell Reports, vol. 44, no. 3, 115387, Elsevier, 2025, doi:10.1016/j.celrep.2025.115387.","ista":"Tavano S, Brückner D, Tasciyan S, Tong X, Kardos R, Schauer A, Hauschild R, Heisenberg C-PJ. 2025. BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports. 44(3), 115387.","chicago":"Tavano, Ste, David Brückner, Saren Tasciyan, Xin Tong, Roland Kardos, Alexandra Schauer, Robert Hauschild, and Carl-Philipp J Heisenberg. “BMP-Dependent Patterning of Ectoderm Tissue Material Properties Modulates Lateral Mesendoderm Cell Migration during Early Zebrafish Gastrulation.” Cell Reports. Elsevier, 2025. https://doi.org/10.1016/j.celrep.2025.115387.","ieee":"S. Tavano et al., “BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation,” Cell Reports, vol. 44, no. 3. Elsevier, 2025.","short":"S. Tavano, D. Brückner, S. Tasciyan, X. Tong, R. Kardos, A. Schauer, R. Hauschild, C.-P.J. Heisenberg, Cell Reports 44 (2025).","ama":"Tavano S, Brückner D, Tasciyan S, et al. BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports. 2025;44(3). doi:10.1016/j.celrep.2025.115387"},"file_date_updated":"2025-03-17T10:26:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"gold","quality_controlled":"1","file":[{"file_name":"2025_CellReports_Tavano.pdf","relation":"main_file","date_updated":"2025-03-17T10:26:54Z","access_level":"open_access","file_id":"19413","date_created":"2025-03-17T10:26:54Z","success":1,"file_size":9067797,"content_type":"application/pdf","creator":"dernst","checksum":"57e05dd1598c807af0afdb32cec039d3"}],"_id":"19404","abstract":[{"lang":"eng","text":"Cell migration is a fundamental process during embryonic development. Most studies in vivo have focused on the migration of cells using the extracellular matrix (ECM) as their substrate for migration. In contrast, much less is known about how cells migrate on other cells, as found in early embryos when the ECM has not yet formed. Here, we show that lateral mesendoderm (LME) cells in the early zebrafish gastrula use the ectoderm as their substrate for migration. We show that the lateral ectoderm is permissive for the animal-pole-directed migration of LME cells, while the ectoderm at the animal pole halts it. These differences in permissiveness depend on the lateral ectoderm being more cohesive than the animal ectoderm, a property controlled by bone morphogenetic protein (BMP) signaling within the ectoderm. Collectively, these findings identify ectoderm tissue cohesion as one critical factor in regulating LME migration during zebrafish gastrulation."}],"intvolume":" 44","month":"03","article_type":"original","DOAJ_listed":"1","volume":44,"publication":"Cell Reports","department":[{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"Bio"}],"date_updated":"2025-10-22T07:00:04Z","external_id":{"isi":["001443652700001"],"pmid":["40057955"]},"oa":1,"corr_author":"1"},{"day":"25","ddc":["570"],"type":"journal_article","isi":1,"language":[{"iso":"eng"}],"scopus_import":"1","date_published":"2025-04-25T00:00:00Z","issue":"17","publication_status":"published","publisher":"AAAS","acknowledgement":"We thank L. Pelkmans and D. Dormann for providing Dyrk3-EGFP plasmids; M. Heuzé for providing a RFP-Pericentrin plasmid; T. Balla for providing a PH-Akt-GFP plasmid; E. Snaar-Jagalska for providing a pLenti-V6.3 Ultra-Chili plasmid; T. Tang for providing CEP120 a plasmid; D. Trono for providing pMD2.G and psSPAX2 plasmids; M. Sixt for providing EB3-mCherry and EMTB-mCherry plasmids as well as 3T3 fibroblasts, Lifeact-GFP Hoxb8 cells, and LX293 cells; M. Duggan for RNA isolation from migrating DCs; M. Schuster from the Biomedical Sequencing Facility at CeMM; J. Schwarz for providing Jurkat T cells; M. Götz for initial transcriptome analysis; M. Götz and F. Merino for discussion and sharing reagents; F. Gärtner for discussions and support; M. Benjamin Braun for critical reading of the manuscript; and the Core Facility Bioimaging, the Core Facility Flow Cytometry, and the Animal Core Facility of the Biomedical Center (BMC) for excellent support.\r\nThis work was supported by Peter Hans Hofschneider Professorship of the Stiftung Experimentelle Biomedizin (J.R.); German Research Foundation grant “CRC914, project A12” (J.R); German Research Foundation grant “SPP2332, project 492014049” (J.R.); LMU Institutional Strategy LMU-Excellent within the framework of the German Excellence Initiative (J.R.); Medical & Clinician Scientist Program (MCSP) LMU Munich (J.K.); Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) under Germany’s Excellence Strategy – EXC2151 – 390873048 (D.B.); Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Grossgeräteantrag 457838313 and under Germany’s Excellence Strategy – EXC 2151 – 390873048 (E.K.); Ministry of Innovation, Science and Research of North-Rhine-Westphalia (fellowship AZ: 421-8.03.03.02-137069) (E.K.); TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments (E.K.); and CZI grant DAF2020-225401 and grant (DOI https://doi.org/10.37921/120055ratwvi) from the Chan Zuckerberg Initiative DAF (R.H.).","date_created":"2025-05-11T22:02:38Z","status":"public","project":[{"_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473","name":"Tools for automation and feedback microscopy","grant_number":"CZI01"}],"author":[{"full_name":"Schmitt, Madeleine T.","first_name":"Madeleine T.","last_name":"Schmitt"},{"last_name":"Kroll","full_name":"Kroll, Janina","first_name":"Janina"},{"last_name":"Ruiz-Fernandez","full_name":"Ruiz-Fernandez, Mauricio J.A.","first_name":"Mauricio J.A."},{"last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522"},{"first_name":"Shaunak","full_name":"Ghosh, Shaunak","last_name":"Ghosh"},{"last_name":"Kameritsch","first_name":"Petra","full_name":"Kameritsch, Petra"},{"full_name":"Merrin, Jack","first_name":"Jack","last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5145-4609"},{"last_name":"Schmid","full_name":"Schmid, Johanna","first_name":"Johanna"},{"full_name":"Stefanowski, Kasia","first_name":"Kasia","last_name":"Stefanowski"},{"last_name":"Thomae","full_name":"Thomae, Andreas W.","first_name":"Andreas W."},{"first_name":"Jingyuan","full_name":"Cheng, Jingyuan","last_name":"Cheng"},{"last_name":"Öztan","full_name":"Öztan, Gamze Naz","first_name":"Gamze Naz"},{"last_name":"Konopka","full_name":"Konopka, Peter","first_name":"Peter"},{"last_name":"Ortega","full_name":"Ortega, Germán Camargo","first_name":"Germán Camargo"},{"last_name":"Penz","first_name":"Thomas","full_name":"Penz, Thomas"},{"last_name":"Bach","full_name":"Bach, Luisa","first_name":"Luisa"},{"last_name":"Baumjohann","first_name":"Dirk","full_name":"Baumjohann, Dirk"},{"last_name":"Bock","first_name":"Christoph","full_name":"Bock, Christoph"},{"last_name":"Straub","full_name":"Straub, Tobias","first_name":"Tobias"},{"last_name":"Meissner","first_name":"Felix","full_name":"Meissner, Felix"},{"orcid":"0000-0001-6165-5738","last_name":"Kiermaier","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","full_name":"Kiermaier, Eva"},{"orcid":"0000-0003-2856-3369","full_name":"Renkawitz, Jörg","first_name":"Jörg","last_name":"Renkawitz","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87"}],"year":"2025","OA_place":"publisher","pmid":1,"article_processing_charge":"Yes","title":"Protecting centrosomes from fracturing enables efficient cell navigation","oa_version":"Published Version","file":[{"relation":"main_file","date_updated":"2025-05-12T07:46:10Z","access_level":"open_access","file_name":"2025_ScienceAdvance_Schmitt.pdf","creator":"dernst","checksum":"e8ba22922fa5b23ccfcce8865f57226c","file_id":"19679","success":1,"date_created":"2025-05-12T07:46:10Z","file_size":2707050,"content_type":"application/pdf"}],"_id":"19663","intvolume":" 11","abstract":[{"text":"The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules that grow radially and exert forces on cargos. At the same time, mechanical stresses from the microenvironment and cellular shape changes compress and bend microtubules. Yet, centrosomes are membraneless organelles, raising the question of how centrosomes withstand mechanical forces. Here, we discover that centrosomes can deform and even fracture. We reveal that centrosomes experience deformations during navigational pathfinding within motile cells. Coherence of the centrosome is maintained by Dyrk3 and cNAP1, preventing fracturing by forces. While cells can compensate for the depletion of centriolar-based centrosomes, the fracturing of centrosomes impedes cellular function by generating coexisting microtubule organizing centers that compete during path navigation and thereby cause cellular entanglement in the microenvironment. Our findings show that cells actively maintain the integrity of the centrosome to withstand mechanical forces. These results suggest that centrosome stability preservation is fundamental, given that almost all cells in multicellular organisms experience forces.","lang":"eng"}],"month":"04","article_type":"original","DOAJ_listed":"1","volume":11,"publication":"Science Advances","department":[{"_id":"Bio"},{"_id":"NanoFab"}],"date_updated":"2025-09-30T12:26:21Z","external_id":{"pmid":["40279414"],"isi":["001476113400016"]},"oa":1,"has_accepted_license":"1","doi":"10.1126/sciadv.adx4047","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2375-2548"]},"article_number":"eadx4047","citation":{"ama":"Schmitt MT, Kroll J, Ruiz-Fernandez MJA, et al. Protecting centrosomes from fracturing enables efficient cell navigation. Science Advances. 2025;11(17). doi:10.1126/sciadv.adx4047","short":"M.T. Schmitt, J. Kroll, M.J.A. Ruiz-Fernandez, R. Hauschild, S. Ghosh, P. Kameritsch, J. Merrin, J. Schmid, K. Stefanowski, A.W. Thomae, J. Cheng, G.N. Öztan, P. Konopka, G.C. Ortega, T. Penz, L. Bach, D. Baumjohann, C. Bock, T. Straub, F. Meissner, E. Kiermaier, J. Renkawitz, Science Advances 11 (2025).","ieee":"M. T. Schmitt et al., “Protecting centrosomes from fracturing enables efficient cell navigation,” Science Advances, vol. 11, no. 17. AAAS, 2025.","chicago":"Schmitt, Madeleine T., Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, et al. “Protecting Centrosomes from Fracturing Enables Efficient Cell Navigation.” Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.adx4047.","apa":"Schmitt, M. T., Kroll, J., Ruiz-Fernandez, M. J. A., Hauschild, R., Ghosh, S., Kameritsch, P., … Renkawitz, J. (2025). Protecting centrosomes from fracturing enables efficient cell navigation. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adx4047","ista":"Schmitt MT, Kroll J, Ruiz-Fernandez MJA, Hauschild R, Ghosh S, Kameritsch P, Merrin J, Schmid J, Stefanowski K, Thomae AW, Cheng J, Öztan GN, Konopka P, Ortega GC, Penz T, Bach L, Baumjohann D, Bock C, Straub T, Meissner F, Kiermaier E, Renkawitz J. 2025. Protecting centrosomes from fracturing enables efficient cell navigation. Science Advances. 11(17), eadx4047.","mla":"Schmitt, Madeleine T., et al. “Protecting Centrosomes from Fracturing Enables Efficient Cell Navigation.” Science Advances, vol. 11, no. 17, eadx4047, AAAS, 2025, doi:10.1126/sciadv.adx4047."},"file_date_updated":"2025-05-12T07:46:10Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_type":"gold","quality_controlled":"1"}]