---
OA_place: repository
OA_type: green
_id: '21963'
abstract:
- lang: eng
text: The cerebral cortex consists of immense numbers of neuronal and glial cell-types
derived from radial glial progenitor (RGP) cells. How RGPs generate appropriate
quantities of distinct cortical cell-types to safeguard a brain of correct size,
is not well understood. However, genetic aberration in human, including mutations
in PTEN, lead to cortical malformation such as macrocephaly, albeit with unknown
etiology. Here we utilized Mosaic Analysis with Double Markers (MADM)-based clonal
analysis and single cell phenotyping to decipher the role of Pten in neurogenic
and gliogenic RGP lineage progression during cortical ontogeny. While neurogenic
RGP lineage progression and projection neuron production was moderately altered
in the absence of Pten, cortical astrocyte production was drastically increased.
Through genetic epistasis experiments we show that the loss of Pten uncouples
astrocyte generation from essential growth factor signaling hubs, funneling into
MAPK. Collectively, our results suggest that Pten regulates RGP lineage progression
with distinct sequential functions in cortical projection neurogenesis and astrocyte
production to ensure the emergence of a correctly-sized cerebral cortex.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: "We thank Kay-Uwe Wagner (Wayne State University) for generously
sharing Jak1/2–flox mouse lines; A.\r\nSommer (VBCF GmbH, NGS Unit) for technical
support; N. Kim, V. Mick, S. Schnabl, S. Gobeil, and L.\r\nAndersen for technical
assistance; all members of the Hippenmeyer lab for discussion and B. Novitch for\r\ncomments
on earlier versions of the manuscript. This research was supported by the Scientific
Service Units\r\n(SSU) of IST Austria through resources provided by the Imaging
and Optics Facility (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF).
O.A.M received support from the Austrian Academy of Sciences\r\nÖAW (DOC 186584),
and N.A. from FWF Elise Richter Program (Grant V1041T). This work was also\r\nsupported
by IST Austria institutional funds; FWF SFB F78 (Neuro Stem Modulation) to S.H.,
and the\r\nEuropean Research Council (ERC) under the European Union’s Horizon 2020
research and innovation\r\nprogramme (grant agreement No 725780 LinPro) to S.H."
article_processing_charge: No
author:
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Amarbayasgalan
full_name: Davaatseren, Amarbayasgalan
id: 70ADC922-B424-11E9-99E3-BA18E6697425
last_name: Davaatseren
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Ana
full_name: Villalba Requena, Ana
id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
last_name: Villalba Requena
orcid: 0000-0002-5615-5277
- first_name: Anna-Magdalena
full_name: Heger, Anna-Magdalena
id: 4B76FFD2-F248-11E8-B48F-1D18A9856A87
last_name: Heger
- first_name: Corentine
full_name: Marie, Corentine
last_name: Marie
- first_name: Bassem A.
full_name: Hassan, Bassem A.
last_name: Hassan
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Miranda O, Contreras X, Pauler F, et al. Pten orchestrates neurogenic radial
glia lineage progression and tunes neocortical astrocyte production. bioRxiv.
doi:10.64898/2026.05.01.722191
apa: Miranda, O., Contreras, X., Pauler, F., Davaatseren, A., Amberg, N., Streicher,
C., … Hippenmeyer, S. (n.d.). Pten orchestrates neurogenic radial glia lineage
progression and tunes neocortical astrocyte production. bioRxiv. https://doi.org/10.64898/2026.05.01.722191
chicago: Miranda, Osvaldo, Ximena Contreras, Florian Pauler, Amarbayasgalan Davaatseren,
Nicole Amberg, Carmen Streicher, Ana Villalba Requena, et al. “Pten Orchestrates
Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production.”
BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722191.
ieee: O. Miranda et al., “Pten orchestrates neurogenic radial glia lineage
progression and tunes neocortical astrocyte production,” bioRxiv. .
ista: Miranda O, Contreras X, Pauler F, Davaatseren A, Amberg N, Streicher C, Villalba
Requena A, Heger A-M, Marie C, Hassan BA, Rülicke T, Hippenmeyer S. Pten orchestrates
neurogenic radial glia lineage progression and tunes neocortical astrocyte production.
bioRxiv, 10.64898/2026.05.01.722191.
mla: Miranda, Osvaldo, et al. “Pten Orchestrates Neurogenic Radial Glia Lineage
Progression and Tunes Neocortical Astrocyte Production.” BioRxiv, doi:10.64898/2026.05.01.722191.
short: O. Miranda, X. Contreras, F. Pauler, A. Davaatseren, N. Amberg, C. Streicher,
A. Villalba Requena, A.-M. Heger, C. Marie, B.A. Hassan, T. Rülicke, S. Hippenmeyer,
BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-06-09T08:08:53Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-06-16T08:57:20Z
day: '05'
ddc:
- '570'
department:
- _id: SiHi
- _id: PreCl
- _id: GradSch
doi: 10.64898/2026.05.01.722191
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.64898/2026.05.01.722191
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
grant_number: F7805
name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
Mechanisms of Neural Stem Cell Lineage Progression
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: bioRxiv
publication_status: submitted
status: public
title: Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical
astrocyte production
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22229'
abstract:
- lang: eng
text: Hippocampal CA3 pyramidal neurons (PNs) form the largest autoassociative network
in the mammalian brain. Whether CA3–CA3 recurrent connectivity is genetically
preconfigured or environmentally shaped during ongoing memory storage is currently
unknown. To address this question, we performed multicellular patch-clamp-based
circuit mapping of up to eight CA3 PNs in the mouse hippocampus at multiple postnatal
time points (P7–8, P18–25, and P45–50). Here, we show that the hippocampal CA3
network undergoes a developmental transformation from local, dense, and random
connectivity to a distributed, sparse, and structured configuration. Thus, sparse
and structured connectivity may emerge via experience-dependent mechanisms. In
parallel, the strength of single synapses is downregulated; single synaptic events
are sufficient to trigger postsynaptic spiking early in development, whereas spatial
summation of several inputs is required at later time points. Biologically inspired
models of memory storage by Hebbian synaptic plasticity and retrieval via pattern
completion suggest that developmental changes improve specific aspects of memory
storage and retrieval. Our results imply a developmental transformation of the
neuronal code and the memory functions in the hippocampal CA3 network.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: M-Shop
- _id: ScienComp
acknowledgement: 'We thank Jose Guzman, Simon Hippenmeyer, and Tim Vogels for critically
reading the manuscript, Jozsef Csicsvari for useful discussions, Florian Marr for
technical assistance, and Eleftheria Kralli-Beller for manuscript editing. This
research was supported by the Scientific Services Units (SSUs) of ISTA: the preclinical
facility (PCF) provided housing and breeding of the animals, the imaging and optics
facility (IOF) offered technical training and state of the art equipment, the Miba
machine shop contributed to the construction and maintenance of multicellular recording
setups, and the scientific computing unit helped with the large-scale simulations.
The project received funding from the European Union’s Horizon 2020 research and
innovation programme (ERC Advanced Grants No 692692 GIANTSYN and 101199096 CA3-SYNGRAM
to P.J.; Marie Skłodowska-Curie Grant 754411 to V.V.B.; Marie Skłodowska-Curie Grant
101026635 to J.F.W.), the Fond zur Förderung der Wissenschaftlichen Forschung (P
36232-B, PAT4178023, and 10.55776/CoE16 to P.J.), and the Nomis Foundation (fellowship
to A.N.-O.). V.V.B. received funding from a CONACyT fellowship (289638).'
article_number: '5540'
article_processing_charge: Yes
article_type: original
author:
- first_name: Victor M
full_name: Vargas Barroso, Victor M
id: 2F55A9DE-F248-11E8-B48F-1D18A9856A87
last_name: Vargas Barroso
- first_name: Jake
full_name: Watson, Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Andrea C
full_name: Navas Olivé, Andrea C
id: 739d26c9-52e8-11ee-8d72-f14d3893b4ce
last_name: Navas Olivé
orcid: 0000-0002-9280-8597
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vargas Barroso VM, Watson J, Navas Olivé AC, Schlögl A, Jonas PM. Developmental
emergence of sparse and structured synaptic connectivity in the hippocampal CA3
memory circuit. Nature Communications. 2026;17. doi:10.1038/s41467-026-71914-x
apa: Vargas Barroso, V. M., Watson, J., Navas Olivé, A. C., Schlögl, A., & Jonas,
P. M. (2026). Developmental emergence of sparse and structured synaptic connectivity
in the hippocampal CA3 memory circuit. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-026-71914-x
chicago: Vargas Barroso, Victor M, Jake Watson, Andrea C Navas Olivé, Alois Schlögl,
and Peter M Jonas. “Developmental Emergence of Sparse and Structured Synaptic
Connectivity in the Hippocampal CA3 Memory Circuit.” Nature Communications.
Springer Nature, 2026. https://doi.org/10.1038/s41467-026-71914-x.
ieee: V. M. Vargas Barroso, J. Watson, A. C. Navas Olivé, A. Schlögl, and P. M.
Jonas, “Developmental emergence of sparse and structured synaptic connectivity
in the hippocampal CA3 memory circuit,” Nature Communications, vol. 17.
Springer Nature, 2026.
ista: Vargas Barroso VM, Watson J, Navas Olivé AC, Schlögl A, Jonas PM. 2026. Developmental
emergence of sparse and structured synaptic connectivity in the hippocampal CA3
memory circuit. Nature Communications. 17, 5540.
mla: Vargas Barroso, Victor M., et al. “Developmental Emergence of Sparse and Structured
Synaptic Connectivity in the Hippocampal CA3 Memory Circuit.” Nature Communications,
vol. 17, 5540, Springer Nature, 2026, doi:10.1038/s41467-026-71914-x.
short: V.M. Vargas Barroso, J. Watson, A.C. Navas Olivé, A. Schlögl, P.M. Jonas,
Nature Communications 17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: Source data are provided with this paper. Additional original
data are available from the corresponding author upon request. Code is available
from https://doi.org/10.15479/AT-ISTA-21442 under the link https://research-explorer.ista.ac.at/download/21442/21443/ca3simu-vargas2026v1.tar.gz
date_created: 2026-06-30T13:05:52Z
date_published: 2026-06-23T00:00:00Z
date_updated: 2026-07-01T06:47:49Z
day: '23'
ddc:
- '570'
department:
- _id: PeJo
- _id: ScienComp
doi: 10.1038/s41467-026-71914-x
ec_funded: 1
external_id:
pmid:
- '42014695'
file:
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checksum: d0b0093493926985b4c268662ff4d556
content_type: application/pdf
creator: dernst
date_created: 2026-07-01T06:46:06Z
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has_accepted_license: '1'
intvolume: ' 17'
language:
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month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
grant_number: '101199096'
name: Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
call_identifier: H2020
grant_number: '101026635'
name: Synaptic computations of the hippocampal CA3 circuitry
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
- _id: 8d9195e9-16d5-11f0-9cad-d075be887a1e
grant_number: PAT 4178023
name: Synaptic networks of human brain
- _id: 26366136-B435-11E9-9278-68D0E5697425
name: Reglas de Conectividad funcional en el hipocampo
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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- id: '21442'
relation: research_data
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Developmental emergence of sparse and structured synaptic connectivity in the
hippocampal CA3 memory circuit
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
_id: '21442'
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
citation:
ama: Schlögl A. CA3Simu v1.06 (vargas2026v1). 2026. doi:10.15479/AT-ISTA-21442
apa: Schlögl, A. (2026). CA3Simu v1.06 (vargas2026v1). Institute of Science and
Technology Austria. https://doi.org/10.15479/AT-ISTA-21442
chicago: Schlögl, Alois. “CA3Simu v1.06 (Vargas2026v1).” Institute of Science and
Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21442.
ieee: A. Schlögl, “CA3Simu v1.06 (vargas2026v1).” Institute of Science and Technology
Austria, 2026.
ista: Schlögl A. 2026. CA3Simu v1.06 (vargas2026v1), Institute of Science and Technology
Austria, 10.15479/AT-ISTA-21442.
mla: Schlögl, Alois. CA3Simu v1.06 (Vargas2026v1). Institute of Science and
Technology Austria, 2026, doi:10.15479/AT-ISTA-21442.
short: A. Schlögl, (2026).
corr_author: '1'
date_created: 2026-03-12T08:20:46Z
date_published: 2026-03-12T00:00:00Z
date_updated: 2026-07-01T06:47:49Z
day: '12'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.15479/AT-ISTA-21442
ec_funded: 1
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creator: schloegl
date_created: 2026-03-12T08:19:14Z
date_updated: 2026-03-12T08:19:14Z
file_id: '21443'
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file_size: 160410
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content_type: text/markdown
creator: schloegl
date_created: 2026-03-12T10:24:45Z
date_updated: 2026-03-12T10:24:45Z
file_id: '21445'
file_name: README.md
file_size: 10923
relation: main_file
success: 1
file_date_updated: 2026-03-12T10:24:45Z
has_accepted_license: '1'
keyword:
- hypocampus
- ca3 simulations
- modelling
license: https://opensource.org/licenses/GPL-3.0
month: '03'
oa: 1
project:
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
grant_number: '101199096'
name: Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
- _id: 8d9195e9-16d5-11f0-9cad-d075be887a1e
grant_number: PAT 4178023
name: Synaptic networks of human brain
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: used_in_publication
status: public
status: public
title: CA3Simu v1.06 (vargas2026v1)
tmp:
legal_code_url: https://www.gnu.org/licenses/gpl-3.0.en.html
name: GNU General Public License 3.0
short: GPL 3.0
type: software
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22254'
abstract:
- lang: eng
text: The global rise of antimicrobial resistance has intensified the search for
new microbial metabolites from underexplored environments and taxonomic groups.
Extreme and geographically isolated habitats such as Antarctic terrestrial ecosystems
represent promising reservoirs of biosynthetic diversity, particularly among rare
and difficult-to-cultivate actinomycetes that may produce chemically diverse metabolites
with potential biotechnological applications. Here, we report the characterization
of kineochelins, a previously undescribed group of siderophores produced by the
Antarctic isolate Actinokineospora sp. UV203, representing a difficult-to-cultivate
actinomycete lineage. Structural elucidation revealed a set of closely related
congeners with a mixed-ligand architecture consistent with metal-chelating activity.
Genome mining combined with transcriptomic analysis identified a dedicated nonribosomal
peptide synthetase-encoding biosynthetic gene cluster responsible for kineochelin
production. Comparative genomic analyses indicated that, although kineochelin
biosynthetic genes share limited similarity with known mixed-ligand siderophores,
their gene content and organization differ substantially, suggesting a distinct
biosynthetic lineage. Functional characterization of the culture supernatant and
an enriched pre-purified kineochelin fraction demonstrated strong and selective
iron chelation, with high affinity for ferric and ferrous iron. Crude culture
extracts inhibited the growth of bacterial strains isolated from the same Antarctic
environment, indicating that kineochelins may contribute to iron-mediated microbial
competition. In addition, kineochelin-enriched pre-purified fractions showed moderate
selective inhibitory activity against the opportunistic yeast pathogen Nakaseomyces
glabratus and a clinical isolate of Saccharomyces cerevisiae associated with invasive
infection. These findings expand the chemical and biosynthetic diversity known
within the genus Actinokineospora and demonstrate that Antarctic rare actinomycetes
represent valuable sources of previously unexplored natural products. The discovery
of kineochelins highlights the potential of genome-guided exploration of polar
microorganisms for identifying bioactive metabolites with relevance for antimicrobial
discovery and biotechnology.
acknowledgement: This work was supported by the Czech Antarctic Research Programme
2025–2027 (VAN 2025) and the University of Vienna via the Research Platform Secondary
Metabolomes of Bacterial Communities (MetaBac). S.K. has received funding from the
European Union's Horizon 2020 research and innovation programme under the Marie
Skłodowska-Curie grant agreement No. 101020356 (DEFCOMANT, https://doi.org/10.3030/101020356)
and MASH StG/CoG (MUNI/SC/1946/2024) by Masaryk University. T.R. and A.L. were funded
in part by the Austrian Science Fund FWF [grant DOI https://doi.org/10.55776/COE7].
M.B. was funded by the Ministry of Health, Czech Republic—conceptual development
of research organization (FNBr, 65269705). The Life Science Compute Cluster LiSC
at the University of Vienna provided the high-performance computing infrastructure
for this study. We thank Julia Ramesmayer and Sara Malinowski (Joint Microbiome
Facility of the Medical University of Vienna and the University of Vienna) for assistance
during high molecular weight extraction and RNA extraction. The authors thank Anna
Fabisikova and Michael Klemm-Abraham from the Mass Spectrometry Centre and the team
of the NMR Centre (both core facilities of the Faculty of Chemistry, University
of Vienna, and members of the Vienna Life Science Instruments) for assistance with
data acquisition. We are thankful to Dr. Jaime Felipe Guerrero Garzón for helpful
discussions on the use of a rrn operon promoter strategy. For open access purposes,
the authors have applied for a CC BY public copyright licence to any author-accepted
manuscript version arising from this submission. Dr. Martin Kello (Department of
Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia)
and Dr. Michal Goga (Department of Plant Biology, Faculty of Science and Center
for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik
University in Košice, Košice, Slovakia), funded by VEGA 1/0498/23, are acknowledged
for their assistance with the antiproliferative assays. This work was supported
by Horizon 2020 Framework Programme, 101020356; Universität Wien, MetaBac; Ministry
of Education, Youth and Sports, VAN 2025; Masarykova Univerzita, MUNI/SC/1946/2024;
Austrian Science Fund, 10.55776/COE7; Ministerstvo Zdravotnictví České Republiky,
FNBr, 65269705; Vedecká grantová agentúra Ministerstva školstva, výskumu, vývoja
a mládeže Slovenskej republiky a Slovenskej akadémie vied, VEGA 1/0498/23.
article_number: e70386
article_processing_charge: Yes
article_type: original
author:
- first_name: Stanislava
full_name: Kralova, Stanislava
last_name: Kralova
- first_name: Peter
full_name: Spacek, Peter
last_name: Spacek
- first_name: Johannes
full_name: Gafriller, Johannes
last_name: Gafriller
- first_name: Matej
full_name: Bezdicek, Matej
last_name: Bezdicek
- first_name: Viktoria
full_name: Medvedcova, Viktoria
last_name: Medvedcova
- first_name: Joana
full_name: Séneca, Joana
last_name: Séneca
- first_name: Jay
full_name: Osvatic, Jay
last_name: Osvatic
- first_name: Ulrike
full_name: Grienke, Ulrike
last_name: Grienke
- first_name: Thomas
full_name: Rattei, Thomas
last_name: Rattei
- first_name: Olga N.
full_name: Sekurova, Olga N.
last_name: Sekurova
- first_name: Sergey B.
full_name: Zotchev, Sergey B.
last_name: Zotchev
- first_name: Martin
full_name: Zehl, Martin
id: 8e016d5b-5d77-11f0-86d2-96cdb3922a55
last_name: Zehl
orcid: 0000-0001-9685-0373
- first_name: Alexander
full_name: Loy, Alexander
last_name: Loy
biorxivid: 1
citation:
ama: Kralova S, Spacek P, Gafriller J, et al. Kineochelins - A new group of siderophores
from an antarctic bacterium. Microbial Biotechnology. 2026;19(6). doi:10.1111/1751-7915.70386
apa: Kralova, S., Spacek, P., Gafriller, J., Bezdicek, M., Medvedcova, V., Séneca,
J., … Loy, A. (2026). Kineochelins - A new group of siderophores from an antarctic
bacterium. Microbial Biotechnology. Wiley. https://doi.org/10.1111/1751-7915.70386
chicago: Kralova, Stanislava, Peter Spacek, Johannes Gafriller, Matej Bezdicek,
Viktoria Medvedcova, Joana Séneca, Jay Osvatic, et al. “Kineochelins - A New Group
of Siderophores from an Antarctic Bacterium.” Microbial Biotechnology.
Wiley, 2026. https://doi.org/10.1111/1751-7915.70386.
ieee: S. Kralova et al., “Kineochelins - A new group of siderophores from
an antarctic bacterium,” Microbial Biotechnology, vol. 19, no. 6. Wiley,
2026.
ista: Kralova S, Spacek P, Gafriller J, Bezdicek M, Medvedcova V, Séneca J, Osvatic
J, Grienke U, Rattei T, Sekurova ON, Zotchev SB, Zehl M, Loy A. 2026. Kineochelins
- A new group of siderophores from an antarctic bacterium. Microbial Biotechnology.
19(6), e70386.
mla: Kralova, Stanislava, et al. “Kineochelins - A New Group of Siderophores from
an Antarctic Bacterium.” Microbial Biotechnology, vol. 19, no. 6, e70386,
Wiley, 2026, doi:10.1111/1751-7915.70386.
short: S. Kralova, P. Spacek, J. Gafriller, M. Bezdicek, V. Medvedcova, J. Séneca,
J. Osvatic, U. Grienke, T. Rattei, O.N. Sekurova, S.B. Zotchev, M. Zehl, A. Loy,
Microbial Biotechnology 19 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The genome sequence and transcriptomic data of strain Actinokineospora
sp. UV203 are available on NCBI (BioProject accession number PRJNA1331526). The
nearly full-length 16S rRNA gene (1395 bp) of strain Actinokineospora sp. UV203
is available on NCBI (accession number PX090945). The NMR data of kineochelin E1
and A1 are deposited in the Natural Products Magnetic Resonance Database (NP-MRD)
under accession numbers NP0352113 and NP0352114, respectively.
date_created: 2026-07-08T09:19:43Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-13T06:59:08Z
day: '01'
ddc:
- '570'
department:
- _id: MassSpec
doi: 10.1111/1751-7915.70386
external_id:
biorxivid:
- 10.64898/2026.02.23.707395
pmid:
- '42210522'
file:
- access_level: open_access
checksum: 4f735714644f1049b22b014225843d8d
content_type: application/pdf
creator: dernst
date_created: 2026-07-13T06:57:19Z
date_updated: 2026-07-13T06:57:19Z
file_id: '22271'
file_name: 2026_MicrobialBiotechnology_Kralova.pdf
file_size: 2497486
relation: main_file
success: 1
file_date_updated: 2026-07-13T06:57:19Z
has_accepted_license: '1'
intvolume: ' 19'
issue: '6'
keyword:
- Actinokineospora
- Antarctica
- antimicrobial discovery
- biosynthetic gene cluster
- genome mining
- microbial competition
- nonribosomalpeptide synthetase
- siderophores
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Microbial Biotechnology
publication_identifier:
eissn:
- 1751-7915
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Kineochelins - A new group of siderophores from an antarctic bacterium
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22289'
abstract:
- lang: eng
text: Single-stranded, helically folded aromatic oligoamides bearing anionic phosphonate
side chains have been shown to bind to some DNA-binding proteins better than DNA
itself. However, these DNA mimic foldamers have until now mainly consisted of
a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence
information. Here, we introduce new monomers designed to display different chemical
functionalities in the major groove of the DNA mimics. Four new Fmoc-protected
amino acid monomers have been synthesized and incorporated into oligomers. Sixteen
foldamer sequences were prepared on solid phase. Their conformations in solution
and in the solid state and their conformational dynamics were investigated using
nuclear magnetic resonance, circular dichroism, molecular modeling, and X-ray
crystallography. The results show that three of the four new monomers behaved
as designed and that their introduction enhances the conformational dynamics of
the DNA mimic foldamers. In a fourth case, conformational behavior proved to be
more complex than expected. The modified sequences retained the ability to bind
to the bacterial histone-like protein HU. These results showcase design strategies
to manipulate large molecular biomimetics in which not only side chains but also
main chain components are varied. The new monomers pave the way to complex DNA
mimic foldamer sequences targeting proteins that recognize sequence-selective
DNA-binding proteins such as transcription factors or restriction enzymes.
acknowledgement: We acknowledge financial support from the European Research Council
(ERC) under the European Union's Horizon Europe Framework Programme (grant agreement
no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral
fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements,
P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero
for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer
precursors, and M. Loos for the purification and analysis of compounds 15a–19a.
We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III,
DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.
article_processing_charge: Yes
article_type: original
author:
- first_name: Jiaojiao
full_name: Wu, Jiaojiao
last_name: Wu
- first_name: Valentina
full_name: Corvaglia, Valentina
last_name: Corvaglia
- first_name: Tulika
full_name: Chakrabortty, Tulika
last_name: Chakrabortty
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Ivan
full_name: Huc, Ivan
last_name: Huc
citation:
ama: Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove
of DNA mimic foldamers. Chemical Science. doi:10.1039/d6sc00798h
apa: Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., & Huc, I. (n.d.).
Tailoring the major groove of DNA mimic foldamers. Chemical Science. Royal
Society of Chemistry. https://doi.org/10.1039/d6sc00798h
chicago: Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal,
and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical
Science. Royal Society of Chemistry, n.d. https://doi.org/10.1039/d6sc00798h.
ieee: J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring
the major groove of DNA mimic foldamers,” Chemical Science. Royal Society
of Chemistry.
ista: Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove
of DNA mimic foldamers. Chemical Science.
mla: Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical
Science, Royal Society of Chemistry, doi:10.1039/d6sc00798h.
short: J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science
(n.d.).
das_tickbox: '1'
dataavailabilitystatement: "CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1,
compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary
crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been
provided as part of the supplementary information (SI). Supplementary information:
SI figures, detailed experimental protocols, crystallographic studies, and characterisation
of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h."
date_created: 2026-07-13T09:41:36Z
date_published: 2026-06-09T00:00:00Z
date_updated: 2026-07-13T11:24:29Z
day: '09'
ddc:
- '540'
department:
- _id: LifeSc
doi: 10.1039/d6sc00798h
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa_version: Published Version
publication: Chemical Science
publication_identifier:
eissn:
- 2041-6539
issn:
- 2041-6520
publication_status: inpress
publisher: Royal Society of Chemistry
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Tailoring the major groove of DNA mimic foldamers
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22301'
abstract:
- lang: eng
text: Auxin, primarily indole-3-acetic acid (IAA), is a central regulator of growth
and development in land plants, but its physiological role in chlorophyte algae
remains unclear. Here, we show that exogenous IAA modulates growth in Chlorella
sorokiniana, Chlorella variabilis, and Chlamydomonas reinhardtii in a concentration-dependent
manner. Low IAA concentrations promoted growth by accelerating the onset of cell
division without affecting cell size, whereas higher concentrations inhibited
proliferation. Radiotracer assays showed that all three species take up and release
IAA across the plasma membrane through a combination of passive diffusion and
energy-dependent, saturable processes. Competition by excess unlabeled natural
and synthetic auxins further supported the presence of carrier-mediated transport
with broad substrate recognition. Phylogenetic analyses identified potential PIN-like
auxin exporters in chlorophytes and other non-plant eukaryotes, and structural
modeling supported conservation of the overall PIN fold and predicted auxin-binding
residues. However, functional assays in Xenopus laevis oocytes, tobacco BY-2 cultured
cells, and Arabidopsis thaliana did not support a role for these proteins in directional
auxin export. Instead, non-plant PIN homologs localized predominantly to the endoplasmic
reticulum and showed limited or no transport activity in heterologous systems.
Together, these findings indicate that auxin responsiveness and basic cellular
auxin transport predate canonical PIN-mediated directional auxin export, which
appears to be a later innovation of the streptophyte lineage.
acknowledged_ssus:
- _id: Bio
- _id: NanoFab
acknowledgement: Research in the Friml group was supported by the European Research
Council (ERC) under grant agreement No. 101142681 (CYNIPS), and by the Austrian
Science Fund (FWF) through projects I 6123-B and P 37051-B. A DOC Fellowship from
the Austrian Academy of Sciences (ÖAW; PR.C0102.1.F.1023.A.2) provided additional
support. Work was partly supported by the Deutsche Forschungsgemeinschaft (DFG,
German Research Foundation) under grant HA 3468/8-1. We thank the Imaging and Optics
Facility (IOF) at the Institute of Science and Technology Austria (ISTA) for support
with confocal imaging, and the Nanofabrication Facility at ISTA for assistance with
microfluidic device fabrication. We also acknowledge the microscopy service of IFIEB
CAS, supported by MEYS CR (LM2023050 Czech-BioImaging). Open Access funding provided
by Institute of Science and Technology Austria.
article_number: jipb.70309
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adrijana
full_name: Smoljan, Adrijana
id: cced8a85-223e-11ed-af04-b0596c55053b
last_name: Smoljan
- first_name: Sarah
full_name: Koutnik‐Abele, Sarah
last_name: Koutnik‐Abele
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Petr
full_name: Klíma, Petr
last_name: Klíma
- first_name: Anita
full_name: Bírošíková, Anita
last_name: Bírošíková
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Maximilian
full_name: Schuster, Maximilian
id: 37e65def-d415-11eb-ae59-a7b67be103db
last_name: Schuster
- first_name: Katarina
full_name: Kurtović, Katarina
last_name: Kurtović
- first_name: Ulrich Z.
full_name: Hammes, Ulrich Z.
last_name: Hammes
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Smoljan A, Koutnik‐Abele S, Vladimirtsev D, et al. Auxin response and PIN‐mediated
transport in chlorophyte algae. Journal of Integrative Plant Biology. 2026.
doi:10.1111/jipb.70309
apa: Smoljan, A., Koutnik‐Abele, S., Vladimirtsev, D., Klíma, P., Bírošíková, A.,
Zhang, Y., … Friml, J. (2026). Auxin response and PIN‐mediated transport in chlorophyte
algae. Journal of Integrative Plant Biology. Wiley. https://doi.org/10.1111/jipb.70309
chicago: Smoljan, Adrijana, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma,
Anita Bírošíková, Yuzhou Zhang, Jack Merrin, et al. “Auxin Response and PIN‐mediated
Transport in Chlorophyte Algae.” Journal of Integrative Plant Biology.
Wiley, 2026. https://doi.org/10.1111/jipb.70309.
ieee: A. Smoljan et al., “Auxin response and PIN‐mediated transport in chlorophyte
algae,” Journal of Integrative Plant Biology. Wiley, 2026.
ista: Smoljan A, Koutnik‐Abele S, Vladimirtsev D, Klíma P, Bírošíková A, Zhang Y,
Merrin J, Schuster M, Kurtović K, Hammes UZ, Petrášek J, Friml J. 2026. Auxin
response and PIN‐mediated transport in chlorophyte algae. Journal of Integrative
Plant Biology., jipb. 70309.
mla: Smoljan, Adrijana, et al. “Auxin Response and PIN‐mediated Transport in Chlorophyte
Algae.” Journal of Integrative Plant Biology, jipb. 70309, Wiley, 2026,
doi:10.1111/jipb.70309.
short: A. Smoljan, S. Koutnik‐Abele, D. Vladimirtsev, P. Klíma, A. Bírošíková, Y.
Zhang, J. Merrin, M. Schuster, K. Kurtović, U.Z. Hammes, J. Petrášek, J. Friml,
Journal of Integrative Plant Biology (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-13T10:44:55Z
date_published: 2026-06-10T00:00:00Z
date_updated: 2026-07-13T14:26:31Z
day: '10'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
- _id: NanoFab
- _id: Bio
doi: 10.1111/jipb.70309
external_id:
pmid:
- '42271607'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/jipb.70309
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Journal of Integrative Plant Biology
publication_identifier:
eissn:
- 1744-7909
issn:
- 1672-9072
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Auxin response and PIN‐mediated transport in chlorophyte algae
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20859'
abstract:
- lang: eng
text: Effective immune responses rely on the efficient migration of leukocytes.
Yet, how temperature regulates migration dynamics at the single-cell level has
remained poorly understood. Using zebrafish embryos and mouse tissue explants,
we found that temperature positively regulates leukocyte migration speed, exploration,
and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures
revealed that this thermokinetic control of cell migration is conserved across
immune cell types, independently of the 3D tissue environment. By applying precise
(sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response
that depends on myosin II activity. Small physiological increases in temperature
(1°C –2°C), as present during fever-like conditions, profoundly increased immune
responses by accelerating arrival times at lymphatic vessels and tissue wounds.
These findings identify myosin-II-dependent actomyosin contractility as a critical
mechanical structure regulating single-cell thermo-adaptability, with physiological
implications for tuning the speed of immune responses in vivo.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: 'The authors would like to acknowledge the Super Resolution Light
Microcopy and Nanoscopy (SLN) Facility of ICFO for their support with imaging experiments,
Johann Osmond (Nanofabrication laboratory, ICFO) for the design and production of
molds for generating confinement coverslip, Merche Rivas for cell culture of immune
cells and further support from the CRG Core Facilities for Genomics and Advanced
Light Microscopy. We would like to thank Michael Sixt for discussions on this work
and the Quidant, Ruprecht, and Wieser lab members for critical reading of the manuscript.
This research was supported by the Scientific Service Units (SSU) of IST-Austria
through resources provided by the Nanofabrication Facility (NFF). C.A. acknowledges
the funding from the European Union’s Horizon 2020 research and innovation programme
under the Marie Skłodowska-Curie grant agreement no 847517 and V.V. from the ICFOstepstone
– PhD Programme funded by the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no 665884. S.W. acknowledges
support through the Spanish Ministry of Economy and Competitiveness via MINECO’s
Plan Nacional (BFU2017-86296-P). V.R. acknowledges funding from the European Union’s
HORIZON-EIC-2021-PATHFINDEROPEN program under grant agreement no. 101046620 and
European Union''s Horizon Europe program under the grant agreement no. 101072123.
E.K. acknowledges funding by a fellowship of the Ministry of Innovation, Science
and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069) and the Deutsche
Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence
Strategy – EXC 2151 – 390873048 and by the TRA Life and Health (University of Bonn)
as part of the Excellence Strategy of the federal and state governments.'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Iván
full_name: Company-Garrido, Iván
last_name: Company-Garrido
- first_name: Alberto
full_name: Zurita Carpio, Alberto
last_name: Zurita Carpio
- first_name: Mariona
full_name: Colomer-Rosell, Mariona
last_name: Colomer-Rosell
- first_name: Bernard
full_name: Ciraulo, Bernard
last_name: Ciraulo
- first_name: Ronja
full_name: Molkenbur, Ronja
last_name: Molkenbur
- first_name: Peter
full_name: Lanzerstorfer, Peter
last_name: Lanzerstorfer
- first_name: Fabio
full_name: Pezzano, Fabio
last_name: Pezzano
- first_name: Costanza
full_name: Agazzi, Costanza
last_name: Agazzi
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Saumey
full_name: Jain, Saumey
last_name: Jain
- first_name: Jeroen M.
full_name: Jacques, Jeroen M.
last_name: Jacques
- first_name: Valeria
full_name: Venturini, Valeria
last_name: Venturini
- first_name: Christian
full_name: Knapp, Christian
last_name: Knapp
- first_name: Yufei
full_name: Xie, Yufei
last_name: Xie
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Julian
full_name: Weghuber, Julian
last_name: Weghuber
- first_name: Marcel
full_name: Schaaf, Marcel
last_name: Schaaf
- first_name: Romain
full_name: Quidant, Romain
last_name: Quidant
- first_name: Eva
full_name: Kiermaier, Eva
id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
last_name: Kiermaier
orcid: 0000-0001-6165-5738
- first_name: Jaime
full_name: Ortega Arroyo, Jaime
last_name: Ortega Arroyo
- first_name: Verena
full_name: Ruprecht, Verena
id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
last_name: Ruprecht
orcid: 0000-0003-4088-8633
- first_name: Stefan
full_name: Wieser, Stefan
id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
last_name: Wieser
orcid: 0000-0002-2670-2217
citation:
ama: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, et al. Myosin II regulates
cellular thermo-adaptability and the efficiency of immune responses. Developmental
Cell. 2026;61(2):356-371.e12. doi:10.1016/j.devcel.2025.10.006
apa: Company-Garrido, I., Zurita Carpio, A., Colomer-Rosell, M., Ciraulo, B., Molkenbur,
R., Lanzerstorfer, P., … Wieser, S. (2026). Myosin II regulates cellular thermo-adaptability
and the efficiency of immune responses. Developmental Cell. Elsevier. https://doi.org/10.1016/j.devcel.2025.10.006
chicago: Company-Garrido, Iván, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard
Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, et al. “Myosin II
Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.”
Developmental Cell. Elsevier, 2026. https://doi.org/10.1016/j.devcel.2025.10.006.
ieee: I. Company-Garrido et al., “Myosin II regulates cellular thermo-adaptability
and the efficiency of immune responses,” Developmental Cell, vol. 61, no.
2. Elsevier, p. 356–371.e12, 2026.
ista: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur
R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini
V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega
Arroyo J, Ruprecht V, Wieser S. 2026. Myosin II regulates cellular thermo-adaptability
and the efficiency of immune responses. Developmental Cell. 61(2), 356–371.e12.
mla: Company-Garrido, Iván, et al. “Myosin II Regulates Cellular Thermo-Adaptability
and the Efficiency of Immune Responses.” Developmental Cell, vol. 61, no.
2, Elsevier, 2026, p. 356–371.e12, doi:10.1016/j.devcel.2025.10.006.
short: I. Company-Garrido, A. Zurita Carpio, M. Colomer-Rosell, B. Ciraulo, R. Molkenbur,
P. Lanzerstorfer, F. Pezzano, C. Agazzi, R. Hauschild, S. Jain, J.M. Jacques,
V. Venturini, C. Knapp, Y. Xie, J. Merrin, J. Weghuber, M. Schaaf, R. Quidant,
E. Kiermaier, J. Ortega Arroyo, V. Ruprecht, S. Wieser, Developmental Cell 61
(2026) 356–371.e12.
das_tickbox: '1'
dataavailabilitystatement: "This study did not generate new unique reagents. Data
are available upon request.\r\n•The custom-made codes used in this study are available
at: https://github.com/mcolomerr/cell_thermo https://github.com/Stefan1980sol/Lymph_entry_simu\r\n•
Any additional information required to reanalyze the data reported in this paper
is available from the lead contact upon request."
date_created: 2025-12-28T23:01:27Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-07-23T06:27:15Z
day: '11'
ddc:
- '570'
department:
- _id: Bio
- _id: NanoFab
doi: 10.1016/j.devcel.2025.10.006
external_id:
pmid:
- '41192429'
file:
- access_level: open_access
checksum: 52fd52d2d19a4514f8fcc1b40f420ca2
content_type: application/pdf
creator: dernst
date_created: 2026-07-23T06:26:25Z
date_updated: 2026-07-23T06:26:25Z
file_id: '22388'
file_name: 2026_DevelopmentalCell_CompanyGarrido.pdf
file_size: 12342817
relation: main_file
success: 1
file_date_updated: 2026-07-23T06:26:25Z
has_accepted_license: '1'
intvolume: ' 61'
issue: '2'
keyword:
- thermobiology
- cell migration
- thermo-adaptability of immune cells
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 356-371.e12
pmid: 1
publication: Developmental Cell
publication_identifier:
eissn:
- 1878-1551
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Myosin II regulates cellular thermo-adaptability and the efficiency of immune
responses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21883'
abstract:
- lang: eng
text: Three-dimensional (3D) printing has rapidly developed from a niche hobbyist
activity into a widely accessible and indispensable technology across multiple
scientific disciplines. Within microscopy, optical engineering laboratories and
imaging core facilities, 3D printing enables creating customised solutions for
sample holders, optical components and everyday laboratory tools that traditionally
required specialised machining. By providing rapid prototyping, low-cost production
and reproducibility, 3D printing facilitates innovation and efficiency in facility
operations. This article provides a perspective on the possibilities, challenges,
and practical aspects of implementing 3D printing within microscopy core facilities.
Instead of providing technical review about 3D printing, we focus on service organisation,
user engagement, resource management and community-driven repositories for design
dissemination. Our aim is to share insights with those considering the implementation
of 3D printing as a service for developing add-on components to ease the operation
of different aspects of the machine-park driven services and those who are managing
advanced instrumentation within research groups.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
acknowledgement: "This work was supported by the Scientific Service Units (SSU) of
Institute of Science and Technology Austria (ISTA) through resources provided by
the Imaging & Optics Facility (IOF) and the MiBa Machine Shop. Specifically; Robert
Hauschild (IOF), sharing designs, insights and pioneering 3D printing activities
at the Imaging and Optics Facility; Bernhard Hochreiter (IOF), for support and testing
of anoxic chamber. We also thank Ana Rita Carvalho Faria and Oliver Biehlmaier (Biozentrum
University of Basel, Imaging Core Facility) for sharing the design of the adopted
power meter.\r\nOpen Access funding provided by Institute of Science and Technology
Austria."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mohammad
full_name: Goudarzi, Mohammad
id: 3384113A-F248-11E8-B48F-1D18A9856A87
last_name: Goudarzi
- first_name: Maximilian
full_name: Schuster, Maximilian
id: 37e65def-d415-11eb-ae59-a7b67be103db
last_name: Schuster
- first_name: Arthur
full_name: Milberger, Arthur
last_name: Milberger
- first_name: Manuel
full_name: Gunkel, Manuel
last_name: Gunkel
- first_name: Stefan
full_name: Terjung, Stefan
last_name: Terjung
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
citation:
ama: Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 3D printing
in core facilities – Low pain, high gain. Journal of Microscopy. 2026;302(3):382-395.
doi:10.1111/jmi.70106
apa: Goudarzi, M., Schuster, M., Milberger, A., Gunkel, M., Terjung, S., & Krens,
G. (2026). 3D printing in core facilities – Low pain, high gain. Journal of
Microscopy. Wiley. https://doi.org/10.1111/jmi.70106
chicago: Goudarzi, Mohammad, Maximilian Schuster, Arthur Milberger, Manuel Gunkel,
Stefan Terjung, and Gabriel Krens. “3D Printing in Core Facilities – Low Pain,
High Gain.” Journal of Microscopy. Wiley, 2026. https://doi.org/10.1111/jmi.70106.
ieee: M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, and G. Krens,
“3D printing in core facilities – Low pain, high gain,” Journal of Microscopy,
vol. 302, no. 3. Wiley, pp. 382–395, 2026.
ista: Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 2026. 3D
printing in core facilities – Low pain, high gain. Journal of Microscopy. 302(3),
382–395.
mla: Goudarzi, Mohammad, et al. “3D Printing in Core Facilities – Low Pain, High
Gain.” Journal of Microscopy, vol. 302, no. 3, Wiley, 2026, pp. 382–95,
doi:10.1111/jmi.70106.
short: M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, G. Krens,
Journal of Microscopy 302 (2026) 382–395.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-05-17T22:02:11Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-27T14:02:46Z
day: '01'
ddc:
- '600'
department:
- _id: Bio
doi: 10.1111/jmi.70106
external_id:
pmid:
- '42104760'
file:
- access_level: open_access
checksum: 06dfad92b1465ed614a1201b4129960a
content_type: application/pdf
creator: dernst
date_created: 2026-07-27T14:01:34Z
date_updated: 2026-07-27T14:01:34Z
file_id: '22593'
file_name: 2026_JourMicroscopy_Goudarzi.pdf
file_size: 4625767
relation: main_file
success: 1
file_date_updated: 2026-07-27T14:01:34Z
has_accepted_license: '1'
intvolume: ' 302'
issue: '3'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 382-395
pmid: 1
publication: Journal of Microscopy
publication_identifier:
eissn:
- 1365-2818
issn:
- 0022-2720
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 3D printing in core facilities – Low pain, high gain
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 302
year: '2026'
...
---
OA_type: closed access
_id: '21950'
abstract:
- lang: eng
text: One Health initiatives are modern paradigms for research and health care practices
in various fields. Concrete definitions of the One Health framework, however,
remain heterogeneous, leading to conceptual problems and uncertainties in the
application of the framework. This article discusses several approaches to the
One Health concept, and their associated consequences, with special focus on animal
experimentation. The first issue addressed is how One Health should be defined,
as well as what (and who) should be considered within a One Health approach. In
order to shed further light on this, we explore the history of animals in biomedical
science, highlighting historical milestones in the use of animal models, as well
as the development and current state of ethical considerations in the field of
animal experimentation. The second issue comes with the inclusion of animal experimentation
per se as part of the One Health concept. Therefore, particular attention is paid
to bioethical principles and the resulting problems that can arise when applying
them to the One Health concept. Arguments such as the idea of inequality between
humans and non-human animals, and the premise that all actions are done for the
benefit of humans, are raised and then used to explore the question of whether
the One Health concept is compatible with existing bioethical principles. Based
on the bioethical principles of protecting the environment, the biodiversity and
biosphere, this paper seeks an inclusive perspective of the One Health concept.
Successful solutions will be based on this concept, which embraces all living
beings. The authors conclude that a multispecies ethics approach could help create
a more ethical ecosystem that is aligned with the wellbeing of all life on a shared
planet.
article_processing_charge: No
article_type: original
author:
- first_name: Yesim Isil
full_name: Ulman, Yesim Isil
last_name: Ulman
- first_name: Nikos
full_name: Kostomitsopoulos, Nikos
last_name: Kostomitsopoulos
- first_name: Samuel
full_name: Camenzind, Samuel
last_name: Camenzind
- first_name: Maria
full_name: Kitsara, Maria
last_name: Kitsara
- first_name: Ilja Richard
full_name: Pavone, Ilja Richard
last_name: Pavone
- first_name: Sophie
full_name: Schober, Sophie
id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
last_name: Schober
citation:
ama: 'Ulman YI, Kostomitsopoulos N, Camenzind S, Kitsara M, Pavone IR, Schober S.
Emerging bioethical conflicts: One Health and animal experimentation. Alternatives
to Laboratory Animals. 2026;54(4):226-235. doi:10.1177/02611929261453330'
apa: 'Ulman, Y. I., Kostomitsopoulos, N., Camenzind, S., Kitsara, M., Pavone, I.
R., & Schober, S. (2026). Emerging bioethical conflicts: One Health and animal
experimentation. Alternatives to Laboratory Animals. SAGE Publications.
https://doi.org/10.1177/02611929261453330'
chicago: 'Ulman, Yesim Isil, Nikos Kostomitsopoulos, Samuel Camenzind, Maria Kitsara,
Ilja Richard Pavone, and Sophie Schober. “Emerging Bioethical Conflicts: One Health
and Animal Experimentation.” Alternatives to Laboratory Animals. SAGE Publications,
2026. https://doi.org/10.1177/02611929261453330.'
ieee: 'Y. I. Ulman, N. Kostomitsopoulos, S. Camenzind, M. Kitsara, I. R. Pavone,
and S. Schober, “Emerging bioethical conflicts: One Health and animal experimentation,”
Alternatives to Laboratory Animals, vol. 54, no. 4. SAGE Publications,
pp. 226–235, 2026.'
ista: 'Ulman YI, Kostomitsopoulos N, Camenzind S, Kitsara M, Pavone IR, Schober
S. 2026. Emerging bioethical conflicts: One Health and animal experimentation.
Alternatives to Laboratory Animals. 54(4), 226–235.'
mla: 'Ulman, Yesim Isil, et al. “Emerging Bioethical Conflicts: One Health and Animal
Experimentation.” Alternatives to Laboratory Animals, vol. 54, no. 4, SAGE
Publications, 2026, pp. 226–35, doi:10.1177/02611929261453330.'
short: Y.I. Ulman, N. Kostomitsopoulos, S. Camenzind, M. Kitsara, I.R. Pavone, S.
Schober, Alternatives to Laboratory Animals 54 (2026) 226–235.
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-07T22:01:36Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-07-27T14:13:17Z
day: '01'
department:
- _id: PreCl
doi: 10.1177/02611929261453330
external_id:
pmid:
- '42185081'
intvolume: ' 54'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
page: 226-235
pmid: 1
publication: Alternatives to Laboratory Animals
publication_identifier:
eissn:
- 2632-3559
issn:
- 0261-1929
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Emerging bioethical conflicts: One Health and animal experimentation'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '20858'
abstract:
- lang: eng
text: Targeted antigen delivery to immune cells, particularly dendritic cells, has
emerged as a promising strategy to enhance therapeutic efficacy of vaccines, while
minimizing adverse effects associated with conventional immunization. In this
study, we use our previously described small glycomimetic molecule that is selectively
recognized by the Langerhans cell (LC)-specific surface receptor Langerin and
demonstrate specific delivery of protein antigens to these specialized dendritic
cells. Our results show that Langerin-mediated antigen delivery significantly
enhances the immune response in vivo, resulting in increased expansion and activation
of antigen-specific T cells, compared to immunization with unmodified antigen.
We demonstrate the feasibility of our LC-targeted platform for immune cell-specific
immunization with protein antigen and underscore the potential of LCs as an access
point for next-generation vaccines and immunotherapies.
acknowledgement: This project was generously supported by Seedfinancing (grant no.
P2282679) of the Austrian Bundesministerium für Digitalisierung und Wirtschaftsstandort
and the Bundesministerium für Klimaschutz, Umwelt, Energie, Mobilität, Innovation,
und Technologie, handled by the Austrian Wirtschaftsservice (aws), as well as by
Life Science Call 2022 (grant no. FO999896442) of the Austrian Research Promotion
Agency (FFG). We thank Mag. Michael Schunn from the PCF of the Institute of Science
and Technology Austria for his continuous technical support.
article_processing_charge: No
article_type: original
author:
- first_name: Ramona
full_name: Rica, Ramona
last_name: Rica
- first_name: Klara
full_name: Klein, Klara
last_name: Klein
- first_name: Litty
full_name: Johnson, Litty
last_name: Johnson
- first_name: Gabriele
full_name: Carta, Gabriele
last_name: Carta
- first_name: Mirza
full_name: Sarcevic, Mirza
last_name: Sarcevic
- first_name: Freyja
full_name: Langer, Freyja
id: 3C1BE782-F248-11E8-B48F-1D18A9856A87
last_name: Langer
- first_name: Christoph
full_name: Rademacher, Christoph
last_name: Rademacher
- first_name: Robert
full_name: Wawrzinek, Robert
last_name: Wawrzinek
- first_name: Federica
full_name: Quattrone, Federica
last_name: Quattrone
- first_name: Florian
full_name: Sparber, Florian
last_name: Sparber
biorxivid: 1
citation:
ama: Rica R, Klein K, Johnson L, et al. Langerhans cell-targeted protein delivery
enhances antigen-specific cellular immune response. Molecular Therapy.
2026;34(1):397-406. doi:10.1016/j.ymthe.2025.10.008
apa: Rica, R., Klein, K., Johnson, L., Carta, G., Sarcevic, M., Langer, F., … Sparber,
F. (2026). Langerhans cell-targeted protein delivery enhances antigen-specific
cellular immune response. Molecular Therapy. Elsevier. https://doi.org/10.1016/j.ymthe.2025.10.008
chicago: Rica, Ramona, Klara Klein, Litty Johnson, Gabriele Carta, Mirza Sarcevic,
Freyja Langer, Christoph Rademacher, Robert Wawrzinek, Federica Quattrone, and
Florian Sparber. “Langerhans Cell-Targeted Protein Delivery Enhances Antigen-Specific
Cellular Immune Response.” Molecular Therapy. Elsevier, 2026. https://doi.org/10.1016/j.ymthe.2025.10.008.
ieee: R. Rica et al., “Langerhans cell-targeted protein delivery enhances
antigen-specific cellular immune response,” Molecular Therapy, vol. 34,
no. 1. Elsevier, pp. 397–406, 2026.
ista: Rica R, Klein K, Johnson L, Carta G, Sarcevic M, Langer F, Rademacher C, Wawrzinek
R, Quattrone F, Sparber F. 2026. Langerhans cell-targeted protein delivery enhances
antigen-specific cellular immune response. Molecular Therapy. 34(1), 397–406.
mla: Rica, Ramona, et al. “Langerhans Cell-Targeted Protein Delivery Enhances Antigen-Specific
Cellular Immune Response.” Molecular Therapy, vol. 34, no. 1, Elsevier,
2026, pp. 397–406, doi:10.1016/j.ymthe.2025.10.008.
short: R. Rica, K. Klein, L. Johnson, G. Carta, M. Sarcevic, F. Langer, C. Rademacher,
R. Wawrzinek, F. Quattrone, F. Sparber, Molecular Therapy 34 (2026) 397–406.
dataavailabilitystatement: The data that support the findings of this study are available
on request from the corresponding authors.
date_created: 2025-12-28T23:01:26Z
date_published: 2026-01-07T00:00:00Z
date_updated: 2026-07-28T07:37:08Z
day: '07'
department:
- _id: PreCl
doi: 10.1016/j.ymthe.2025.10.008
external_id:
biorxivid:
- 10.1101/2025.05.05.652195
intvolume: ' 34'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.05.05.652195
month: '01'
oa: 1
oa_version: Preprint
page: 397-406
publication: Molecular Therapy
publication_identifier:
eissn:
- 1525-0024
issn:
- 1525-0016
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Langerhans cell-targeted protein delivery enhances antigen-specific cellular
immune response
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2026'
...
---
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22608'
abstract:
- lang: eng
text: For tissues to spread, they must deform while staying intact. How spreading
tissues balance flexibility with integrity is not yet well understood. Here, we
show that keratin intermediate filaments adapt tissue mechanical resilience to
the stresses arising in epithelial tissues during spreading. By analyzing the
expansion of the enveloping cell layer (EVL) over the yolk cell in zebrafish embryos
in vivo, we find that keratin network maturation in EVL cells is promoted by stresses
building up within the spreading tissue. Through genetic interference and tissue
rheology experiments, complemented by a vertex model with mechanochemical feedback,
we demonstrate that stress-induced keratin network maturation in the EVL increases
tissue viscosity, to prevent tissue rupture. Further, keratins are required in
the yolk cell for mechanosensitive actomyosin network contraction and flow, the
forces pulling the EVL. These dual mechanosensitive functions of keratins enable
a balance between pulling force production and EVL mechanical resilience, ensuring
uniform and robust tissue spreading.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: LifeSc
- _id: EM-Fac
acknowledgement: We thank all members of the Heisenberg, Henkes, and Hannezo groups
for their support. We are also grateful to the Imaging and Optics, Scientific Computing,
Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their
technical assistance and support. Numerical simulations were performed using the
computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary
Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided
by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020
research and innovation programme (grant agreement No. 665385). This work was supported
by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to
C.-P.H.
article_number: '6499'
article_processing_charge: Yes
article_type: original
author:
- first_name: Suyash
full_name: Naik, Suyash
id: 2C0B105C-F248-11E8-B48F-1D18A9856A87
last_name: Naik
orcid: 0000-0001-8421-5508
- first_name: Yann-Edwin
full_name: Keta, Yann-Edwin
last_name: Keta
- first_name: Kornelija
full_name: Pranjic-Ferscha, Kornelija
id: 4362B3C2-F248-11E8-B48F-1D18A9856A87
last_name: Pranjic-Ferscha
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Silke
full_name: Henkes, Silke
last_name: Henkes
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Naik S, Keta Y-E, Pranjic-Ferscha K, Hannezo EB, Henkes S, Heisenberg C-PJ.
Keratins coordinate tissue spreading by balancing spreading forces with tissue
material properties. Nature Communications. 2026;17. doi:10.1038/s41467-026-72366-z
apa: Naik, S., Keta, Y.-E., Pranjic-Ferscha, K., Hannezo, E. B., Henkes, S., &
Heisenberg, C.-P. J. (2026). Keratins coordinate tissue spreading by balancing
spreading forces with tissue material properties. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-026-72366-z
chicago: Naik, Suyash, Yann-Edwin Keta, Kornelija Pranjic-Ferscha, Edouard B Hannezo,
Silke Henkes, and Carl-Philipp J Heisenberg. “Keratins Coordinate Tissue Spreading
by Balancing Spreading Forces with Tissue Material Properties.” Nature Communications.
Springer Nature, 2026. https://doi.org/10.1038/s41467-026-72366-z.
ieee: S. Naik, Y.-E. Keta, K. Pranjic-Ferscha, E. B. Hannezo, S. Henkes, and C.-P.
J. Heisenberg, “Keratins coordinate tissue spreading by balancing spreading forces
with tissue material properties,” Nature Communications, vol. 17. Springer
Nature, 2026.
ista: Naik S, Keta Y-E, Pranjic-Ferscha K, Hannezo EB, Henkes S, Heisenberg C-PJ.
2026. Keratins coordinate tissue spreading by balancing spreading forces with
tissue material properties. Nature Communications. 17, 6499.
mla: Naik, Suyash, et al. “Keratins Coordinate Tissue Spreading by Balancing Spreading
Forces with Tissue Material Properties.” Nature Communications, vol. 17,
6499, Springer Nature, 2026, doi:10.1038/s41467-026-72366-z.
short: S. Naik, Y.-E. Keta, K. Pranjic-Ferscha, E.B. Hannezo, S. Henkes, C.-P.J.
Heisenberg, Nature Communications 17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "The authors declare that the minimum dataset that is necessary
to\r\ninterpret, verify, and extend the research in this article is included in\r\nthe
supplementary information, the source data, and the archived data\r\nrepository
(https://doi.org/10.15479/AT-ISTA-21137). This is also available\r\non GitHub at
https://github.com/Suyash-Naik/2026-\r\nKeratinepithlialspreadingcoordinate-Data.
Source data are provided\r\nwith this paper. The framework to develop the vertex
models used in this paper are\r\navailable online on GitHub and archived in the
source data provided.\r\nCustom scripts used for analysis of imaging and simulation
data are\r\nprovided along with data files for all panels in the source data for
this\r\nmanuscript on GitHub and in data repo (https://doi.org/10.15479/ATISTA-\r\n21137).
Framework for the vertex model is available at https://\r\ngithub.com/yketta/cells.
Code for analysis is available on GitHub\r\nhttps://github.com/Suyash-Naik/2026-\r\nKeratinepithlialspreadingcoordinate-Data."
date_created: 2026-07-29T09:10:35Z
date_published: 2026-07-17T00:00:00Z
date_updated: 2026-07-29T10:33:31Z
day: '17'
ddc:
- '570'
department:
- _id: Bio
- _id: CaHe
- _id: EdHa
doi: 10.1038/s41467-026-72366-z
external_id:
pmid:
- '42143048'
file:
- access_level: open_access
checksum: f26d96e180c1d034d9c9c8f57c3c258b
content_type: application/pdf
creator: dernst
date_created: 2026-07-29T10:27:25Z
date_updated: 2026-07-29T10:27:25Z
file_id: '22609'
file_name: 2026_NatureComm_Naik.pdf
file_size: 15363936
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file_date_updated: 2026-07-29T10:27:25Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f060199-16d5-11f0-9cad-f3253b266c46
grant_number: PAT 5044023
name: Keratins in epithelial tissue spreading
- _id: 252C3B08-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1250-B20
name: Nano-Analytics of Cellular Systems
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '20465'
relation: earlier_version
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Keratins coordinate tissue spreading by balancing spreading forces with tissue
material properties
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '22619'
abstract:
- lang: eng
text: Planar germanium is currently the only semiconducting platform where high-coherence
spin qubits and proximity-induced superconductivity have each been demonstrated.
Recent research into spin qubits in Ge/SiGe heterostructures has focused on increasing
the thickness of the SiGe capping layer, reporting improvements in the electrostatic
noise levels. Meanwhile, heterostructures with thinner capping layers remain rather
unexplored, despite the potential advantages for proximity-induced superconductivity.
Here, we study a Ge/SiGe heterostructure with a thin SiGe cap d - 4nm and investigate
its viability to host low-noise quantum dots. To keep the thermal budget compatible
with superconducting layers, low-temperature oxide deposition processes were developed
and implemented for the gate dielectrics. The charge noise level of the fabricated
devices is estimated to be 1.8 +- 1.0 μeV/ square HZ, comparable to devices
fabricated on shallow heterostructures ( d - 20nm) with high-temperature deposited
oxides. Low charge noise levels, together with the straightforward integration
of superconductors, make this heterostructure an attractive platform for prototyping
hybrid semiconducting–superconducting devices.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: 'We sincerely thank Nick van Loo, Greg Mazur, Dhananjay Joshi, and
Srijit Goswami for their inputs on low-temperature HfOx deposition; Matias Urdampilleta
and Daniel Jirovec for discussions; and Kristen Léonard for the careful reading
of the manuscript. This research was supported by the Scientific Service Units of
ISTA through resources provided by the Miba Machine Shop and the Nanofabrication
facility. The authors acknowledge support from the NOMIS Foundation; the European
Innovation Council Pathfinder Grant No. 101115315 (QuKiT); the FWF Projects with
DOI:10.55776/F86, DOI:10.55776/PAT7682124, and DOI:10.55776/P36507; and the HE-MSCA-PF
project with DOI:10.3030/101150858. ICN2 is supported by the Severo Ochoa Program
from Spanish MCIN/AEI (Grant No.: CEX2021-001214-S) and is funded by the CERCA Program/Generalitat
de Catalunya. ICN2 acknowledges funding from Generalitat de Catalunya (No. 2021SGR00457).
We acknowledge support from the CSIC Interdisciplinary Thematic Platform (PTI+)
on Quantum Technologies (PTI-QTEP+).'
article_number: '033505'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Maksim
full_name: Borovkov, Maksim
id: 1fd0975f-8b61-11ed-b69e-d149334f28c5
last_name: Borovkov
- first_name: Yona A
full_name: Schell, Yona A
id: fe39122d-06bb-11ec-a33b-9e22b40e40a5
last_name: Schell
- first_name: Dina
full_name: Sokolova, Dina
id: 2d2d62f8-72f0-11ef-b75a-8ec3e8a60032
last_name: Sokolova
- first_name: Kevin Etienne Robert
full_name: Roux, Kevin Etienne Robert
id: 53f93ea2-803f-11ed-ab7e-b283135794ef
last_name: Roux
- first_name: Paul
full_name: Falthansl-Scheinecker, Paul
id: 85b43b21-15b2-11ec-abd3-e2c252cc2285
last_name: Falthansl-Scheinecker
- first_name: Giorgio
full_name: Fabris, Giorgio
id: 298cf6f3-1ff6-11ee-9fa6-d94cfa0b3352
last_name: Fabris
- first_name: Devashish C
full_name: Shah, Devashish C
id: de191434-4e7e-11ef-bf4b-9a056fc19fc3
last_name: Shah
orcid: 0009-0007-5829-7707
- first_name: Jaime
full_name: Saez Mollejo, Jaime
id: e0390f72-f6e0-11ea-865d-862393336714
last_name: Saez Mollejo
- first_name: Rodolfo
full_name: Previdi, Rodolfo
id: bc4ea1dc-00ce-11ec-8a4e-b325ca8b9876
last_name: Previdi
- first_name: Inas
full_name: Taha, Inas
last_name: Taha
- first_name: Aziz
full_name: Genç, Aziz
last_name: Genç
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Stefano
full_name: Calcaterra, Stefano
last_name: Calcaterra
- first_name: Afonso De Cerdeira
full_name: Oliveira, Afonso De Cerdeira
last_name: Oliveira
- first_name: Daniel
full_name: Chrastina, Daniel
last_name: Chrastina
- first_name: Giovanni
full_name: Isella, Giovanni
last_name: Isella
- first_name: Anton
full_name: Bubis, Anton
id: 1f6212b5-f795-11ec-9c0c-de4780302890
last_name: Bubis
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Borovkov M, Schell YA, Sokolova D, et al. Low-noise quantum dots in ultra-shallow
Ge/SiGe heterostructures for prototyping hybrid semiconducting–superconducting
devices. Applied Physics Letters. 2026;129(3). doi:10.1063/5.0333142
apa: Borovkov, M., Schell, Y. A., Sokolova, D., Roux, K. E. R., Falthansl-Scheinecker,
P., Fabris, G., … Katsaros, G. (2026). Low-noise quantum dots in ultra-shallow
Ge/SiGe heterostructures for prototyping hybrid semiconducting–superconducting
devices. Applied Physics Letters. AIP Publishing. https://doi.org/10.1063/5.0333142
chicago: Borovkov, Maksim, Yona A Schell, Dina Sokolova, Kevin Etienne Robert Roux,
Paul Falthansl-Scheinecker, Giorgio Fabris, Devashish C Shah, et al. “Low-Noise
Quantum Dots in Ultra-Shallow Ge/SiGe Heterostructures for Prototyping Hybrid
Semiconducting–Superconducting Devices.” Applied Physics Letters. AIP Publishing,
2026. https://doi.org/10.1063/5.0333142.
ieee: M. Borovkov et al., “Low-noise quantum dots in ultra-shallow Ge/SiGe
heterostructures for prototyping hybrid semiconducting–superconducting devices,”
Applied Physics Letters, vol. 129, no. 3. AIP Publishing, 2026.
ista: Borovkov M, Schell YA, Sokolova D, Roux KER, Falthansl-Scheinecker P, Fabris
G, Shah DC, Saez Mollejo J, Previdi R, Taha I, Genç A, Arbiol J, Calcaterra S,
Oliveira ADC, Chrastina D, Isella G, Bubis A, Katsaros G. 2026. Low-noise quantum
dots in ultra-shallow Ge/SiGe heterostructures for prototyping hybrid semiconducting–superconducting
devices. Applied Physics Letters. 129(3), 033505.
mla: Borovkov, Maksim, et al. “Low-Noise Quantum Dots in Ultra-Shallow Ge/SiGe Heterostructures
for Prototyping Hybrid Semiconducting–Superconducting Devices.” Applied Physics
Letters, vol. 129, no. 3, 033505, AIP Publishing, 2026, doi:10.1063/5.0333142.
short: M. Borovkov, Y.A. Schell, D. Sokolova, K.E.R. Roux, P. Falthansl-Scheinecker,
G. Fabris, D.C. Shah, J. Saez Mollejo, R. Previdi, I. Taha, A. Genç, J. Arbiol,
S. Calcaterra, A.D.C. Oliveira, D. Chrastina, G. Isella, A. Bubis, G. Katsaros,
Applied Physics Letters 129 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The data that support the findings of this study are openly
available in Institute of Science and Technology repository at http://doi.org/10.15479/AT-ISTA-22242,
Ref. 50.
date_created: 2026-08-02T22:01:53Z
date_published: 2026-07-20T00:00:00Z
date_updated: 2026-08-03T11:08:39Z
day: '20'
department:
- _id: GeKa
- _id: GradSch
- _id: NanoFab
doi: 10.1063/5.0333142
external_id:
arxiv:
- '2602.21363'
intvolume: ' 129'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2602.21363
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: bdc2ca30-d553-11ed-ba76-cf164a5bb811
grant_number: '101115315'
name: Quantum bits with Kitaev Transmons
- _id: 34a66131-11ca-11ed-8bc3-a31681c6b03e
grant_number: F8606
name: 'Center for Correlated Quantum Materials and Solid State Quantum Systems:
Conventional and unconventional topological superconductors'
- _id: 5b9e579c-ab3d-11f0-914f-88754c5b5a3f
grant_number: PAT 7682124
name: Superconducting spin qubits in planar Ge
- _id: bd8bd29e-d553-11ed-ba76-f0070d4b237a
grant_number: P36507
name: Merging spin and superconducting qubits in planar Ge
- _id: 8ea8abf7-16d5-11f0-9cad-c41e56ec8bb3
grant_number: '101150858'
name: Realization and Manipulation of a Planar hybrid superconducting Andreev spin
qubit in Germanium
publication: Applied Physics Letters
publication_identifier:
eissn:
- 1077-3118
issn:
- 0003-6951
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
related_material:
record:
- id: '22242'
relation: research_data
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Low-noise quantum dots in ultra-shallow Ge/SiGe heterostructures for prototyping
hybrid semiconducting–superconducting devices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 129
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22645'
abstract:
- lang: eng
text: Nanocrystal superlattices are commonly formed by changing concentration, solvent
conditions, or particle surface chemistry. Although effective, these approaches
alter multiple contributions to the interparticle potential simultaneously, making
it difficult to isolate the interactions responsible for ordering or to control
assembly in chemically complex environments. Here, we show that oligomeric species
present in a nanocrystal reaction medium drive superlattice formation through
a depletion mechanism. Using PbTe nanocrystals as a model system, we identify
Pb–oleate oligomers in the crude reaction mixture, characterize their solution
structure, and quantify their contribution to the interparticle potential, establishing
depletion as the dominant short-range interaction governing spontaneous body-centered
cubic superlattice formation. We then confirm the depletion origin of ordering
by showing that varying depletant concentration predictably shifts the order–disorder
boundary and produces a thermally reversible transition between dispersed and
ordered states ─ behavior that is inconsistent with van der Waals or ligand-mediated
mechanisms but is a direct consequence of depletion control. Having established
and validated the mechanism, we demonstrate that the same depletion framework
can be deliberately activated in purified dispersions and transferred across nanocrystal
systems of different composition and shape, including anisotropic and binary assemblies.
These results establish precursor-derived depletion as a general and chemically
grounded mechanism for nanocrystal superlattice formation, and show that collective
ordering can be programmed through the surrounding medium rather than through
particle surface modification.
acknowledged_ssus:
- _id: EM-Fac
- _id: NMR
- _id: LifeSc
acknowledgement: ISTA and the Werner Siemens Foundation financially supported this
work. The Scientific Service Units (SSU) of ISTA supported this research through
resources provided by the Electron Microscopy Facility (EMF), NMR Facility, and
the Lab Support Facility (LSF). M.E. acknowledges financial support from Deutsche
Forschungsgemeinschaft through Collaborative Research Centre 1411. We thank Dr.
Tommaso Constanzo and Tobias Kleinhanns for assistance with high-quality electron
microscope image acquisition, Dr. Jeonghyun Park for providing NCs, Dr. Mariano
Calcabrini for assistance with the NMR study, and Prof. Jonathan De Roo for fruitful
discussions. This work benefited from the use of the SasView application, originally
developed under NSF award DMR-0520547. SasView contains code developed with funding
from the European Union’s Horizon 2020 research and innovation program under the
SINE2020 project, grant agreement No. 654000.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Seungho
full_name: Lee, Seungho
id: BB243B88-D767-11E9-B658-BC13E6697425
last_name: Lee
orcid: 0000-0002-6962-8598
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Aiswarya
full_name: Rayaroth Puthiyaveettil, Aiswarya
id: 8aceb01b-8972-11ed-ae7b-d5fe53775add
last_name: Rayaroth Puthiyaveettil
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Michael
full_name: Engel, Michael
last_name: Engel
- first_name: Ihor
full_name: Cherniukh, Ihor
id: d03b62b2-5976-11ef-a8d7-9525504b7895
last_name: Cherniukh
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Lee S, Balazs D, Rayaroth Puthiyaveettil A, et al. Reaction medium asan architect
of nanocrystal superlattices. Journal of the AmericanChemical Society.
2026;148(29):31245-31252. doi:10.1021/jacs.6c07859
apa: Lee, S., Balazs, D., Rayaroth Puthiyaveettil, A., Horta, S., Goodrich, C. P.,
Engel, M., … Ibáñez, M. (2026). Reaction medium asan architect of nanocrystal
superlattices. Journal of the AmericanChemical Society. American Chemical
Society. https://doi.org/10.1021/jacs.6c07859
chicago: Lee, Seungho, Daniel Balazs, Aiswarya Rayaroth Puthiyaveettil, Sharona
Horta, Carl Peter Goodrich, Michael Engel, Ihor Cherniukh, and Maria Ibáñez. “Reaction
Medium Asan Architect of Nanocrystal Superlattices.” Journal of the AmericanChemical
Society. American Chemical Society, 2026. https://doi.org/10.1021/jacs.6c07859.
ieee: S. Lee et al., “Reaction medium asan architect of nanocrystal superlattices,”
Journal of the AmericanChemical Society, vol. 148, no. 29. American Chemical
Society, pp. 31245–31252, 2026.
ista: Lee S, Balazs D, Rayaroth Puthiyaveettil A, Horta S, Goodrich CP, Engel M,
Cherniukh I, Ibáñez M. 2026. Reaction medium asan architect of nanocrystal superlattices.
Journal of the AmericanChemical Society. 148(29), 31245–31252.
mla: Lee, Seungho, et al. “Reaction Medium Asan Architect of Nanocrystal Superlattices.”
Journal of the AmericanChemical Society, vol. 148, no. 29, American Chemical
Society, 2026, pp. 31245–52, doi:10.1021/jacs.6c07859.
short: S. Lee, D. Balazs, A. Rayaroth Puthiyaveettil, S. Horta, C.P. Goodrich, M.
Engel, I. Cherniukh, M. Ibáñez, Journal of the AmericanChemical Society 148 (2026)
31245–31252.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-04T06:29:31Z
date_published: 2026-07-15T00:00:00Z
date_updated: 2026-08-04T06:47:13Z
day: '15'
ddc:
- '540'
department:
- _id: MaIb
- _id: LifeSc
- _id: GradSch
- _id: CaGo
doi: 10.1021/jacs.6c07859
external_id:
pmid:
- '42532904'
file:
- access_level: open_access
checksum: 063314ae5ac4225ebd4436aa8707d113
content_type: application/pdf
creator: dernst
date_created: 2026-08-04T06:40:17Z
date_updated: 2026-08-04T06:40:17Z
file_id: '22646'
file_name: 2026_JACS_Lee.pdf
file_size: 6564594
relation: main_file
success: 1
file_date_updated: 2026-08-04T06:40:17Z
has_accepted_license: '1'
intvolume: ' 148'
issue: '29'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 31245-31252
pmid: 1
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Journal of the AmericanChemical Society
publication_identifier:
eissn:
- 1520-5126
issn:
- 0002-7863
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Reaction medium asan architect of nanocrystal superlattices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 148
year: '2026'
...
---
OA_place: publisher
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_id: '22295'
abstract:
- lang: eng
text: 'Despite the functional diversity of over 100 causal genes1,2,3, phenotypic
convergence across models may reveal common neurobiological processes in autism
spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse
models of ASD using single-nucleus multi-omic sequencing across three developmental
stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked
mutations converged on perturbations of the radial glial cell lineage. These alterations
reflect a transient developmental delay rather than lasting lineage misspecification
and resolve by postnatal stages. Molecularly, the largest transcriptional differences
emerged in neurons at early postnatal stages. These changes included downregulation
of synaptic and ion channel-related genes, consistent with homeostatic adaptation
or delayed maturation. Network analysis showed molecular convergence across models
within each developmental stage, suggesting that diverse mutations linked to ASD
impinge on common, stage-specific processes. Convergence becomes less pronounced
by postnatal day 14, highlighting the dynamic nature of ASD-associated changes.
Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology
corroborated this pattern: mutants generally showed altered neuronal excitability
and synaptic properties with model-specific nuances. Our study also highlighted
sex-specific gene expression alterations, with female mice often displaying larger
effect sizes than male mice. Together, our findings provide a comprehensive view
of developmental cellular and molecular dynamics across models of ASD.'
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical
assistance; A. Stichelberger and S. Liegenfeld for the management of our animal
colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance;
C. Jansen and the Scientific Computing Facility for bioinformatics support and technical
assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation
sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support
with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted
in Fig. 1; and all members of the laboratory of G.N. for their support and discussions.
This study was supported by the Scientific Service Units of ISTA through resources
provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk
RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter
Core Facilities, member of the Vienna BioCenter. This work was supported by a European
Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by
the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding
provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lena A
full_name: Schwarz, Lena A
id: 29A8453C-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
orcid: 0000-0002-9033-9096
- first_name: Sergey
full_name: Isaev, Sergey
last_name: Isaev
- first_name: Michela
full_name: Lisi, Michela
id: 39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c
last_name: Lisi
- first_name: Daniel
full_name: Malzl, Daniel
last_name: Malzl
- first_name: Christoph
full_name: Büschl, Christoph
id: 2a8c054c-0913-11ee-9159-f8ef515809ed
last_name: Büschl
- first_name: Sabrina
full_name: Ladstätter, Sabrina
last_name: Ladstätter
- first_name: Bárbara
full_name: Oliveira, Bárbara
id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87
last_name: Oliveira
- first_name: Matteo
full_name: Barel, Matteo
id: 8959927b-2236-11ed-bd6e-ea83d94ade0e
last_name: Barel
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Chaitanya
full_name: Chintaluri, Chaitanya
id: BA06AFEE-A4BA-11EA-AE5C-14673DDC885E
last_name: Chintaluri
orcid: 0000-0003-4252-1608
- first_name: Sarah
full_name: Gorkiewicz, Sarah
id: f141a35d-15a9-11ec-9fb2-fef6becc7b6f
last_name: Gorkiewicz
- first_name: Mohammad
full_name: Goudarzi, Mohammad
id: 3384113A-F248-11E8-B48F-1D18A9856A87
last_name: Goudarzi
- first_name: Tereza
full_name: Belinova, Tereza
id: 0bf89b6a-d28b-11eb-8bd6-f43768e4d368
last_name: Belinova
- first_name: Stephan
full_name: Reichl, Stephan
last_name: Reichl
- first_name: Gintarė
full_name: Sendžikaitė, Gintarė
id: dd6d52f2-c50d-11eb-9548-bcf0ff82b344
last_name: Sendžikaitė
- first_name: Satish
full_name: Arcot Jayaram, Satish
id: b0bbee33-09f7-11eb-909c-8b358058d28a
last_name: Arcot Jayaram
orcid: 0000-0002-2479-2669
- first_name: Peter
full_name: Koppensteiner, Peter
id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
last_name: Koppensteiner
orcid: 0000-0002-3509-1948
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Jörg
full_name: Menche, Jörg
last_name: Menche
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
- first_name: Peter Vasili
full_name: Kharchenko, Peter Vasili
id: 0095641e-7eb7-11f1-8665-aec51a2ab5e0
last_name: Kharchenko
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across
autism spectrum disorder mouse models. Nature. 2026. doi:10.1038/s41586-026-10679-1
apa: Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., Büschl, C., … Novarino,
G. (2026). Cortical development dynamics across autism spectrum disorder mouse
models. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10679-1
chicago: Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl,
Christoph Büschl, Sabrina Ladstätter, et al. “Cortical Development Dynamics across
Autism Spectrum Disorder Mouse Models.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-026-10679-1.
ieee: L. A. Schwarz et al., “Cortical development dynamics across autism
spectrum disorder mouse models,” Nature. Springer Nature, 2026.
ista: Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, Büschl C, Ladstätter S, Oliveira
B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl
S, Sendžikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche
J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics
across autism spectrum disorder mouse models. Nature.
mla: Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum
Disorder Mouse Models.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10679-1.
short: L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. Büschl, S. Ladstätter,
B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi,
T. Belinova, S. Reichl, G. Sendžikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M.
Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino,
Nature (2026).
corr_author: '1'
dataavailabilitystatement: Single-nucleus multiomics data are available from the Gene
Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment
(refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz).
Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz).
Source data are provided with this paper. Scripts and analyses that support the
main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome).
date_created: 2026-07-13T09:47:21Z
date_published: 2026-06-17T00:00:00Z
date_updated: 2026-08-04T09:29:55Z
day: '17'
ddc:
- '570'
department:
- _id: AnKi
- _id: GaNo
- _id: TiVo
- _id: ScienComp
- _id: GradSch
- _id: Bio
- _id: PreCl
doi: 10.1038/s41586-026-10679-1
external_id:
pmid:
- '42310454'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-026-10679-1
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6
grant_number: '101044865'
name: Toward an understanding of the brain interstitial system and the extracellular
proteome in health and autism spectrum disorders
- _id: 9B91375C-BA93-11EA-9121-9846C619BF3A
grant_number: '707964'
name: Critical windows and reversibility of ASD associated with mutations in chromatin
remodelers
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232
name: Molecular Drug Targets
- _id: ebb38b5d-77a9-11ec-83b8-a42e08120a88
grant_number: FG1803 49015
name: Neurobiology of anxiety in autism spectrum disorders
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/patterns-in-genetic-chaos/
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Cortical development dynamics across autism spectrum disorder mouse models
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22105'
abstract:
- lang: eng
text: Protein conformational energy landscapes are shaped not only by intramolecular
interactions but also by their environment. In protein crystals and protein–protein
complexes, intermolecular contacts alter this energy landscape, but the exact
nature of this alteration is difficult to decipher. Understanding how the crystal
lattice affects protein dynamics is crucial for crystallography-based studies
of motion, yet its influence on collective motions remains unclear. Aromatic ring
flips in the hydrophobic core represent sensitive probes of such dynamics. Here,
we compare the kinetics of aromatic ring flips in the protein GB1 in crystals,
in complex with its binding partner IgG, and in solution, combining advanced isotope
labelling with quantitative NMR methods. We show that rings in the core flip nearly
a thousand times less frequently in crystals than in solution. Enhanced-sampling
molecular dynamics simulations, based on a crystal structure of a GB1 variant
reported in this work, reproduce these elevated barriers and reveal how the crystal
restrains motions.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank N. R. Skrynnikov and O. O. Lebedenko (St. Petersburg) for
insightful discussions and for performing exploratory MD simulations. We are grateful
to T. Schubeis (Lyon) for advice on GB1 crystallization and R. Schmid for initial
crystallization trials. We thank C. Mueller-Dieckmann for assistance with room-temperature
X-ray crystallography data collection on beamline ID30B at the ESRF, which is acknowledged
for providing beamtime through its In-House Research programme. We thank S. Falkner
for assistance with constructing the structural model of the IgG:GB1 complex. We
thank J. Lewandowski for providing feedback on the paper and granting access to
backbone relaxation data of IgG:GB1T2Q and GB1T2Q microcrystals. This research was
supported by the Scientific Service Units (SSU) of the Institute of Science and
Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
and the Lab Support Facilities. We thank P. Rovó and M. V. Falcón for excellent
support of the NMR facility. L.M.B. is recipient of a DOC fellowship of the Austrian
Academy of Sciences at the Institute of Science and Technology Austria (grant number
PR10660EAW01). C.C. acknowledges the European Research Council (grant project 101097272
‘MilliInMicro’) and the Métropole du Grand Nancy (grant project ‘ARC’). BM07-FIP2
is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under
grant agreement ANR-21-ESRE-0011.Open access funding provided by Institute of Science
and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Haohao
full_name: Fu, Haohao
last_name: Fu
- first_name: Benjamin
full_name: Tatman, Benjamin
id: 71cda2f3-e604-11ee-a1df-da10587eda3f
last_name: Tatman
- first_name: Matthias
full_name: Dreydoppel, Matthias
last_name: Dreydoppel
- first_name: Anna
full_name: Kapitonova, Anna
id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
last_name: Kapitonova
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Ulrich
full_name: Weininger, Ulrich
last_name: Weininger
- first_name: Sylvain
full_name: Engilberge, Sylvain
last_name: Engilberge
- first_name: Christophe
full_name: Chipot, Christophe
last_name: Chipot
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Fu H, Tatman B, et al. Aromatic ring flips reveal reshaping of protein
dynamics in crystals and complexes. Nature Chemistry. 2026;18:1221-1230.
doi:10.1038/s41557-026-02155-0
apa: Becker, L. M., Fu, H., Tatman, B., Dreydoppel, M., Kapitonova, A., Balazs,
D., … Schanda, P. (2026). Aromatic ring flips reveal reshaping of protein dynamics
in crystals and complexes. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-026-02155-0
chicago: Becker, Lea Marie, Haohao Fu, Benjamin Tatman, Matthias Dreydoppel, Anna
Kapitonova, Daniel Balazs, Ulrich Weininger, Sylvain Engilberge, Christophe Chipot,
and Paul Schanda. “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in
Crystals and Complexes.” Nature Chemistry. Springer Nature, 2026. https://doi.org/10.1038/s41557-026-02155-0.
ieee: L. M. Becker et al., “Aromatic ring flips reveal reshaping of protein
dynamics in crystals and complexes,” Nature Chemistry, vol. 18. Springer
Nature, pp. 1221–1230, 2026.
ista: Becker LM, Fu H, Tatman B, Dreydoppel M, Kapitonova A, Balazs D, Weininger
U, Engilberge S, Chipot C, Schanda P. 2026. Aromatic ring flips reveal reshaping
of protein dynamics in crystals and complexes. Nature Chemistry. 18, 1221–1230.
mla: Becker, Lea Marie, et al. “Aromatic Ring Flips Reveal Reshaping of Protein
Dynamics in Crystals and Complexes.” Nature Chemistry, vol. 18, Springer
Nature, 2026, pp. 1221–30, doi:10.1038/s41557-026-02155-0.
short: L.M. Becker, H. Fu, B. Tatman, M. Dreydoppel, A. Kapitonova, D. Balazs, U.
Weininger, S. Engilberge, C. Chipot, P. Schanda, Nature Chemistry 18 (2026) 1221–1230.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The cryo and room-temperature crystal structures of GB1QDD
are deposited at the PDB under the access codes 9I2I and 9T8Z, respectively. The
solid-state NMR backbone assignment of GB1QDD is deposited at the BMRB under the
access code 53330. NMR spectra, analysis scripts and raw data are publicly available
at the ISTA research explorer (https://doi.org/10.15479/AT-ISTA-20641)120. Files
to reproduce the enhanced-sampling MD simulations are publicly available at the
ISTA research explorer (https://doi.org/10.15479/AT-ISTA-21145)121.
date_created: 2026-06-21T22:03:01Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-08-04T09:32:45Z
day: '01'
ddc:
- '540'
department:
- _id: PaSc
- _id: LifeSc
doi: 10.1038/s41557-026-02155-0
external_id:
pmid:
- '42271006'
file:
- access_level: open_access
checksum: 1069fb27949fd2cb641b043b3a96a580
content_type: application/pdf
creator: dernst
date_created: 2026-07-28T06:58:35Z
date_updated: 2026-07-28T06:58:35Z
file_id: '22595'
file_name: 2026_NatureChemistry_Becker.pdf
file_size: 2618184
relation: main_file
success: 1
file_date_updated: 2026-07-28T06:58:35Z
has_accepted_license: '1'
intvolume: ' 18'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 1221-1230
pmid: 1
project:
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
grant_number: '26777'
name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
approaches
publication: Nature Chemistry
publication_identifier:
eissn:
- '17554349'
issn:
- '17554330'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: research_data
url: https://ista.ac.at/en/news/how-proteins-breathe/
record:
- id: '20641'
relation: research_data
status: public
- id: '21145'
relation: research_data
status: public
- id: '22334'
relation: dissertation_contains
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 18
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22734'
abstract:
- lang: eng
text: Silver selenide (Ag2Se) is a promising near-room-temperature thermoelectric
material, but its narrow stoichiometric window and β–α phase transition complicate
reproducible microstructure control. Here, we present a mismatch-assisted microstructure
engineering strategy in which Ag2Se particles are treated with polyanionic ZnSe
complexes and consolidated through the β–α transition to introduce ZnSe nanoprecipitates,
Ag2Se/ZnSe interfaces, and local strain fields. The crystallographic mismatch
between ZnSe and Ag2Se, together with the Zn2+/Ag+ size difference, amplifies
phase-transition-induced deformation and promotes high-density dislocations with
periodic strain modulations. This defect architecture suppresses grain coarsening,
removes excess Ag, limits Ag-interstitial formation, and reduces lattice thermal
conductivity through lattice softening and multiscale phonon scattering. Ag2Se–4%ZnSe
nanocomposites achieve a peak zTmax of 1.13 at 369 K and a zTavg of 1.08 from
300 to 380 K, demonstrating mismatch-driven defect engineering through the β–α
phase transition as a route for optimizing Ag2Se-based thermoelectrics.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: NanoFab
- _id: MassSpec
acknowledgement: 'Open access funding provided by Institute of Science and Technology
Austria. M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation.
The Scientific Service Units (SSU) of ISTA supported this work through resources
provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF),
the Nanofabrication Facility (NNF), and the Mass Spectrometry Facility. Y.L. acknowledges
funding from the National Natural Science Foundation of China (NSFC) (grant no.
22209034) and the Fundamental Research Funds for the Central Universities (JZ2024HGTB0239).
M.H. acknowledges funding from Australian Research Council (FT230100316), and the
high-performance computing resources provided by National Computational Infrastructure
(it39) and Pawsey Supercomputing Centre (pawsey1075). ICN2 acknowledges funding
from Generalitat de Catalunya 2021SGR00457. The authors thank support from the project
AMaDE (PID2023-149158OB-C43), funded by MCIN/AEI/10.13039/501100011033/ and by the
“ERDF Away of making Europe”, by the “European Union”. ICN2 is supported by the
Severo Ochoa program from Spanish MCIN/AEI (grant no.: CEX2021-001214-S) and is
funded by the CERCA Programme/Generalitat de Catalunya. Authors acknowledge the
use of instrumentation as well as the technical advice provided by the Joint Electron
Microscopy Center at ALBA (JEMCA). ICN2 acknowledges funding from Grant IU16-014206
(METCAM-FIB) funded by the European Union through the European Regional Development
Fund (ERDF), with the support of the Ministry of Research and Universities, Generalitat
de Catalunya. ICN2 is founding member of e-DREAM. (91)'
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Tobias
full_name: Kleinhanns, Tobias
id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
last_name: Kleinhanns
orcid: 0000-0003-1537-7436
- first_name: Maria Chiara
full_name: Spadaro, Maria Chiara
last_name: Spadaro
- first_name: Aziz
full_name: Genç, Aziz
last_name: Genç
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Navita
full_name: Navita, Navita
id: 6ebe278d-ba0b-11ee-8184-f34cdc671de4
last_name: Navita
orcid: 0000-0001-7408-8197
- first_name: Tommaso
full_name: Costanzo, Tommaso
id: D93824F4-D9BA-11E9-BB12-F207E6697425
last_name: Costanzo
orcid: 0000-0001-9732-3815
- first_name: Ewelina
full_name: Dutkiewicz, Ewelina
id: 0601cc46-c082-11ec-9b07-bb29641d1de9
last_name: Dutkiewicz
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Min
full_name: Hong, Min
last_name: Hong
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Liu Y, Kleinhanns T, Spadaro MC, et al. Exploiting mismatch strain and the
β–α phase transition for microstructural engineering in thermoelectric Ag2Se.
ACS Energy Letters. 2026;11(8):5752-5762. doi:10.1021/acsenergylett.6c01499
apa: Liu, Y., Kleinhanns, T., Spadaro, M. C., Genç, A., Horta, S., Jakhar, N., …
Ibáñez, M. (2026). Exploiting mismatch strain and the β–α phase transition for
microstructural engineering in thermoelectric Ag2Se. ACS Energy Letters.
American Chemical Society. https://doi.org/10.1021/acsenergylett.6c01499
chicago: Liu, Yu, Tobias Kleinhanns, Maria Chiara Spadaro, Aziz Genç, Sharona Horta,
Navita Jakhar, Tommaso Costanzo, et al. “Exploiting Mismatch Strain and the β–α
Phase Transition for Microstructural Engineering in Thermoelectric Ag2Se.” ACS
Energy Letters. American Chemical Society, 2026. https://doi.org/10.1021/acsenergylett.6c01499.
ieee: Y. Liu et al., “Exploiting mismatch strain and the β–α phase transition
for microstructural engineering in thermoelectric Ag2Se,” ACS Energy Letters,
vol. 11, no. 8. American Chemical Society, pp. 5752–5762, 2026.
ista: Liu Y, Kleinhanns T, Spadaro MC, Genç A, Horta S, Jakhar N, Costanzo T, Dutkiewicz
E, Arbiol J, Hong M, Ibáñez M. 2026. Exploiting mismatch strain and the β–α phase
transition for microstructural engineering in thermoelectric Ag2Se. ACS Energy
Letters. 11(8), 5752–5762.
mla: Liu, Yu, et al. “Exploiting Mismatch Strain and the β–α Phase Transition for
Microstructural Engineering in Thermoelectric Ag2Se.” ACS Energy Letters,
vol. 11, no. 8, American Chemical Society, 2026, pp. 5752–62, doi:10.1021/acsenergylett.6c01499.
short: Y. Liu, T. Kleinhanns, M.C. Spadaro, A. Genç, S. Horta, N. Jakhar, T. Costanzo,
E. Dutkiewicz, J. Arbiol, M. Hong, M. Ibáñez, ACS Energy Letters 11 (2026) 5752–5762.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-18T11:34:03Z
date_published: 2026-08-14T00:00:00Z
date_updated: 2026-08-19T05:53:33Z
day: '14'
ddc:
- '540'
department:
- _id: MassSpec
- _id: MaIb
- _id: GradSch
- _id: EM-Fac
doi: 10.1021/acsenergylett.6c01499
file:
- access_level: open_access
checksum: 4d75c5a79d112c845c9eecba8838db38
content_type: application/pdf
creator: dernst
date_created: 2026-08-19T05:52:41Z
date_updated: 2026-08-19T05:52:41Z
file_id: '22736'
file_name: 2026_ACSEnergyLetters_Liu.pdf
file_size: 6806815
relation: main_file
success: 1
file_date_updated: 2026-08-19T05:52:41Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 5752-5762
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: ACS Energy Letters
publication_identifier:
eissn:
- 2380-8195
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Exploiting mismatch strain and the β–α phase transition for microstructural
engineering in thermoelectric Ag2Se
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22715'
abstract:
- lang: eng
text: 'Grazing-incidence small-angle scattering (GISAS) is a relatively young technique
with important applications in thin-film technology and untapped potential when
it comes to 2D analysis on an absolute intensity scale. Approaching standardization
and reference methods early is foundational for reproducibility and comparability
across laboratories and reduction of systematic error sources. It underpins trust
in data obtained and accelerates innovation by ensuring that scientists work from
a common methodological baseline. Accordingly, obtaining reproducible results
from different GISAS instruments requires an agreement on how measurements are
performed, instruments calibrated and terms defined. To pave the way for standardization
and reference methods, we surveyed GISAS practitioners on what comes before an
experiment: hardware, software, sample alignment and instrument calibration. Twenty-two
questions were designed to elucidate the state of the art, which can be used for
the development of reference methods. Our data on 27 instruments provide the basis
for standardization. With very few exceptions, we found laboratories prepared
to implement future reference methods, but no consensus emerges naturally for
sample alignment and instrument calibration. We, that is the GISAS community,
are thus in a position to embark on the journey of standardization.'
acknowledgement: "The authors thank all respondents for their participation in the\r\nquestionnaire.
We plan to make further use of the wealth of\r\nthe dataset going forward. We thank
Xenocs for sharing\r\napproximate data on GISAXS equipment sales and Adrian\r\nRennie
for helpful discussions. Open access funding enabled\r\nand organized by Projekt
DEAL."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Anja F.
full_name: Hörmann, Anja F.
last_name: Hörmann
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Ingo
full_name: Breßler, Ingo
last_name: Breßler
- first_name: Sumea
full_name: Klokic, Sumea
last_name: Klokic
- first_name: Melika
full_name: Moradi, Melika
last_name: Moradi
- first_name: Eduardo
full_name: Solano, Eduardo
last_name: Solano
- first_name: Annika
full_name: Stellhorn, Annika
last_name: Stellhorn
- first_name: Brian R.
full_name: Pauw, Brian R.
last_name: Pauw
citation:
ama: 'Hörmann AF, Balazs D, Breßler I, et al. Grazing-incidence scattering surveyed:
Towards reference methods for alignment and calibration. Journal of Applied
Crystallography. 2026;59(4):1247-1253. doi:10.1107/S1600576726005741'
apa: 'Hörmann, A. F., Balazs, D., Breßler, I., Klokic, S., Moradi, M., Solano, E.,
… Pauw, B. R. (2026). Grazing-incidence scattering surveyed: Towards reference
methods for alignment and calibration. Journal of Applied Crystallography.
International Union of Crystallography. https://doi.org/10.1107/S1600576726005741'
chicago: 'Hörmann, Anja F., Daniel Balazs, Ingo Breßler, Sumea Klokic, Melika Moradi,
Eduardo Solano, Annika Stellhorn, and Brian R. Pauw. “Grazing-Incidence Scattering
Surveyed: Towards Reference Methods for Alignment and Calibration.” Journal
of Applied Crystallography. International Union of Crystallography, 2026.
https://doi.org/10.1107/S1600576726005741.'
ieee: 'A. F. Hörmann et al., “Grazing-incidence scattering surveyed: Towards
reference methods for alignment and calibration,” Journal of Applied Crystallography,
vol. 59, no. 4. International Union of Crystallography, pp. 1247–1253, 2026.'
ista: 'Hörmann AF, Balazs D, Breßler I, Klokic S, Moradi M, Solano E, Stellhorn
A, Pauw BR. 2026. Grazing-incidence scattering surveyed: Towards reference methods
for alignment and calibration. Journal of Applied Crystallography. 59(4), 1247–1253.'
mla: 'Hörmann, Anja F., et al. “Grazing-Incidence Scattering Surveyed: Towards Reference
Methods for Alignment and Calibration.” Journal of Applied Crystallography,
vol. 59, no. 4, International Union of Crystallography, 2026, pp. 1247–53, doi:10.1107/S1600576726005741.'
short: A.F. Hörmann, D. Balazs, I. Breßler, S. Klokic, M. Moradi, E. Solano, A.
Stellhorn, B.R. Pauw, Journal of Applied Crystallography 59 (2026) 1247–1253.
das_tickbox: '1'
dataavailabilitystatement: "The response data are available at https://doi.org/10.5281/\r\nzenodo.18712813.
The literate programming source of this\r\nwork is available at https://doi.org/10.5281/zenodo.18713631."
date_created: 2026-08-16T22:01:43Z
date_published: 2026-08-01T00:00:00Z
date_updated: 2026-08-20T06:14:07Z
day: '01'
ddc:
- '540'
department:
- _id: LifeSc
doi: 10.1107/S1600576726005741
file:
- access_level: open_access
checksum: 8dbad0ab078338021e2cfe722211df7b
content_type: application/pdf
creator: dernst
date_created: 2026-08-20T05:51:36Z
date_updated: 2026-08-20T05:51:36Z
file_id: '22739'
file_name: 2026_JourAppliedCrystallography_Hoermann.pdf
file_size: 6692218
relation: main_file
success: 1
file_date_updated: 2026-08-20T05:51:36Z
has_accepted_license: '1'
intvolume: ' 59'
issue: '4'
keyword:
- grazing incidence
- reference methods
- calibration
- standardization
- community
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 1247-1253
publication: Journal of Applied Crystallography
publication_identifier:
eissn:
- 1600-5767
issn:
- 0021-8898
publication_status: published
publisher: International Union of Crystallography
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Grazing-incidence scattering surveyed: Towards reference methods for alignment
and calibration'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21746'
abstract:
- lang: eng
text: As vertebrates transitioned from water to land, locomotion shifted from undulatory
swimming to limb-based movement. How spinal circuits and their cell types evolved
to support this transition remains unclear. We leverage frog metamorphosis, which
recapitulates this transition within a single organism, to define how spinal circuits
generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture
is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons.
As limbs develop and their movement complexifies, spinal circuits expand in neuron
number and subtype diversity. This expansion is most pronounced for V1 inhibitory
neurons, which increase ∼70-fold and diversify into transcriptionally distinct
subtypes. Disrupting transcription factors defining emerging motor and V1 populations
reveals molecular segregation between swim and limb circuits, highlighting the
role of subtype diversity in motor coordination. A multifold increase in inhibitory
neuron diversity thus underlies the tail-to-limb locomotor transition, providing
a framework for spinal circuit adaptation during vertebrate evolution.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'We would like to thank the members of the Sweeney Lab, Mario de
Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript.
We are also grateful to Tom Jessell and Chris Kintner for their scientific insight
and mentorship during the conception of this project. It would also have not been
possible without the technical support of the Aquatics and Imaging and Optics Facility
support teams (ISTA). We thank Martin Estermann for preparing the initial draft
of the graphical abstract and Niki Barolini for the final version. In addition,
we thank our funding sources for providing the resources to do these experiments:
GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon
Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special
Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.),
Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858
(to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH
grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC)
(to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472
(to Z.H.), and Project A.L.S. (to S.B.-M.).'
article_number: '117227'
article_processing_charge: Yes
article_type: original
author:
- first_name: David
full_name: Vijatovic, David
id: cf391e77-ec3c-11ea-a124-d69323410b58
last_name: Vijatovic
orcid: 0000-0002-5494-0941
- first_name: 'Florina Alexandra '
full_name: 'Toma, Florina Alexandra '
id: 2f73f876-f128-11eb-9611-b96b5a30cb0e
last_name: Toma
- first_name: Y
full_name: Ignatyev, Y
last_name: Ignatyev
- first_name: Zoe P
full_name: Harrington, Zoe P
id: a8144562-32c9-11ee-b5ce-d9800628bda2
last_name: Harrington
orcid: 0009-0008-0158-4032
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Matthijs Geert
full_name: Smits, Matthijs Geert
id: 7a231d52-e216-11ee-a0bb-8acd55f8f1f0
last_name: Smits
- first_name: Marco
full_name: Dalla Vecchia, Marco
id: 02a7a869-ff06-11ed-a87f-86649d6077e5
last_name: Dalla Vecchia
- first_name: Alexandra J.
full_name: Trevisan, Alexandra J.
last_name: Trevisan
- first_name: Phillip
full_name: Chapman, Phillip
last_name: Chapman
- first_name: Mara
full_name: Julseth, Mara
id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
last_name: Julseth
- first_name: Susan
full_name: Brenner-Morton, Susan
last_name: Brenner-Morton
- first_name: Mariano I.
full_name: Gabitto, Mariano I.
last_name: Gabitto
- first_name: Jeremy S.
full_name: Dasen, Jeremy S.
last_name: Dasen
- first_name: Jay B.
full_name: Bikoff, Jay B.
last_name: Bikoff
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory
cell types with emergence of limb movement. Cell Reports. 2026;45(4). doi:10.1016/j.celrep.2026.117227
apa: Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M.,
Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory
cell types with emergence of limb movement. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2026.117227
chicago: Vijatovic, David, Florina Alexandra Toma, Y Ignatyev, Zoe P Harrington,
Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold
Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” Cell
Reports. Elsevier, 2026. https://doi.org/10.1016/j.celrep.2026.117227.
ieee: D. Vijatovic et al., “Multifold increase in spinal inhibitory cell
types with emergence of limb movement,” Cell Reports, vol. 45, no. 4. Elsevier,
2026.
ista: Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits
MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto
MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory
cell types with emergence of limb movement. Cell Reports. 45(4), 117227.
mla: Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types
with Emergence of Limb Movement.” Cell Reports, vol. 45, no. 4, 117227,
Elsevier, 2026, doi:10.1016/j.celrep.2026.117227.
short: D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild,
M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton,
M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:43Z
date_published: 2026-04-28T00:00:00Z
date_updated: 2026-08-20T14:45:18Z
day: '28'
ddc:
- '570'
department:
- _id: LoSw
- _id: GradSch
- _id: TiVo
- _id: Bio
- _id: NiBa
doi: 10.1016/j.celrep.2026.117227
external_id:
pmid:
- '41964955 '
file:
- access_level: open_access
checksum: 0d26cdb5b8d8dec3a911d8261a65cdef
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T12:20:10Z
date_updated: 2026-05-04T12:20:10Z
file_id: '21795'
file_name: 2026_CellReports_Vijatovic.pdf
file_size: 14925958
relation: main_file
success: 1
file_date_updated: 2026-05-04T12:20:10Z
has_accepted_license: '1'
intvolume: ' 45'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
grant_number: '101041551'
name: Development and Evolution of Tetrapod Motor Circuits
- _id: 8da85f50-16d5-11f0-9cad-eab8b0ff6c9e
grant_number: F7814
name: 'Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb
transition: cell type to connection diversity'
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
grant_number: FTI21-D-046
name: Development of V1 interneuron diversity during swim-to-walk transition of
Xenopus metamorphosis
publication: Cell Reports
publication_identifier:
eissn:
- 2211-1247
issn:
- 2639-1856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '22667'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Multifold increase in spinal inhibitory cell types with emergence of limb movement
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2026'
...
---
OA_type: closed access
_id: '20870'
abstract:
- lang: eng
text: RNA sequencing (RNA-seq) methodologies have evolved rapidly, offering powerful
tools to study gene expression, transcriptome dynamics, and molecular mechanisms
in various biological contexts. However, the complexity of these approaches poses
challenges in data interpretation, sensitivity, and applicability. This chapter
provides a comprehensive overview of RNA-seq methodologies, highlighting their
advantages, limitations, and applications, particularly in cardiovascular research.
Bulk RNA sequencing enables high-throughput gene expression profiling but lacks
the resolution to capture cellular heterogeneity and spatial context. Direct RNA
sequencing preserves native RNA modifications, offering insights into post-transcriptional
regulation, though it remains technically challenging. Single-cell RNA sequencing
(scRNA-seq) and spatial transcriptomics (ST) bridge these gaps by resolving transcriptomic
complexity at the cellular level and within tissue architecture, providing crucial
insights into disease mechanisms such as atherosclerosis. By summarizing the strengths
and limitations of these methodologies, this chapter aims to guide researchers
in selecting the most suitable transcriptomic approach for their studies, ultimately
advancing precision medicine and biomarker discovery in cardiovascular disease.
article_processing_charge: No
author:
- first_name: Victoria
full_name: Stopa, Victoria
last_name: Stopa
- first_name: Miron
full_name: Sopić, Miron
last_name: Sopić
- first_name: Guanliang
full_name: Li, Guanliang
last_name: Li
- first_name: Judith
full_name: Sluimer, Judith
last_name: Sluimer
- first_name: José
full_name: Basílio, José
last_name: Basílio
- first_name: Sander W.
full_name: van der Laan, Sander W.
last_name: van der Laan
- first_name: David P.
full_name: Kreil, David P.
last_name: Kreil
- first_name: Yvan
full_name: Devaux, Yvan
last_name: Devaux
- first_name: Bernhard
full_name: Hochreiter, Bernhard
id: e6cab3de-17f6-11ed-9210-c1e42e045e9d
last_name: Hochreiter
citation:
ama: 'Stopa V, Sopić M, Li G, et al. Essentials of transcriptomic methods: Navigating
through RNA sequencing and beyond. In: Devaux Y, Sopic M, eds. Transcriptomics
in Atherosclerosis. Elsevier; 2025:131-172. doi:10.1016/b978-0-443-33064-3.00016-5'
apa: 'Stopa, V., Sopić, M., Li, G., Sluimer, J., Basílio, J., van der Laan, S. W.,
… Hochreiter, B. (2025). Essentials of transcriptomic methods: Navigating through
RNA sequencing and beyond. In Y. Devaux & M. Sopic (Eds.), Transcriptomics
in Atherosclerosis (pp. 131–172). Elsevier. https://doi.org/10.1016/b978-0-443-33064-3.00016-5'
chicago: 'Stopa, Victoria, Miron Sopić, Guanliang Li, Judith Sluimer, José Basílio,
Sander W. van der Laan, David P. Kreil, Yvan Devaux, and Bernhard Hochreiter.
“Essentials of Transcriptomic Methods: Navigating through RNA Sequencing and Beyond.”
In Transcriptomics in Atherosclerosis, edited by Yvan Devaux and Miron
Sopic, 131–72. Elsevier, 2025. https://doi.org/10.1016/b978-0-443-33064-3.00016-5.'
ieee: 'V. Stopa et al., “Essentials of transcriptomic methods: Navigating
through RNA sequencing and beyond,” in Transcriptomics in Atherosclerosis,
Y. Devaux and M. Sopic, Eds. Elsevier, 2025, pp. 131–172.'
ista: 'Stopa V, Sopić M, Li G, Sluimer J, Basílio J, van der Laan SW, Kreil DP,
Devaux Y, Hochreiter B. 2025.Essentials of transcriptomic methods: Navigating
through RNA sequencing and beyond. In: Transcriptomics in Atherosclerosis. , 131–172.'
mla: 'Stopa, Victoria, et al. “Essentials of Transcriptomic Methods: Navigating
through RNA Sequencing and Beyond.” Transcriptomics in Atherosclerosis,
edited by Yvan Devaux and Miron Sopic, Elsevier, 2025, pp. 131–72, doi:10.1016/b978-0-443-33064-3.00016-5.'
short: V. Stopa, M. Sopić, G. Li, J. Sluimer, J. Basílio, S.W. van der Laan, D.P.
Kreil, Y. Devaux, B. Hochreiter, in:, Y. Devaux, M. Sopic (Eds.), Transcriptomics
in Atherosclerosis, Elsevier, 2025, pp. 131–172.
date_created: 2025-12-29T12:16:22Z
date_published: 2025-10-24T00:00:00Z
date_updated: 2026-01-05T11:49:54Z
day: '24'
department:
- _id: Bio
doi: 10.1016/b978-0-443-33064-3.00016-5
editor:
- first_name: Yvan
full_name: Devaux, Yvan
last_name: Devaux
- first_name: Miron
full_name: Sopic, Miron
last_name: Sopic
language:
- iso: eng
month: '10'
oa_version: None
page: 131-172
publication: Transcriptomics in Atherosclerosis
publication_identifier:
isbn:
- '9780443330643'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Essentials of transcriptomic methods: Navigating through RNA sequencing and
beyond'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '21920'
abstract:
- lang: eng
text: 'Vertebrates display remarkable diversity of sensorimotor behaviors, each
adapted to distinct ecological and survival demands. This diversity raises fundamental
questions about the evolutionary origin of motor control: do conserved spinal
circuits underlie these behaviors, and how have they diverged across species.
Recent studies detail spinal cell-type architecture in mammals but comparable,
high-resolution atlases of the non-mammalian spinal cord are lacking. Here, we
compare spinal cord cell types between fish, frogs, mice and humans, spanning
∼450 million years of evolution. Across species, we define highly conserved programs
of cell type specification that segregate spinal neurons into nearly identical
cardinal classes during development. This contrasts with adult stages, when spinal
cell-type composition selectively diverges for excitatory neuron subpopulations.
Using spatial transcriptomics, we localize this species divergence to the superficial,
dorsal spinal cord, where variant neuropeptide expression defines mammalian-specific
cell types. The most dorsal spinal cord thus emerges as a recently evolved hub
for sensory integration in mammals, a neospinal cord analogous to the neocortex.'
acknowledgement: "We would like to thank the members of the Sweeney Lab for discussion
and support; Andrey\r\nBydanov for technical assistance with single-cell sequencing
processing; and Jay Bikoff,\r\nNikos Konstantinides, Maria Tosches, and Graziana
Gatto for comments on the manuscript. \r\nThis research was supported by: Horizon
Europe ERC Starting Grant 101041551 (L.B.S,\r\nY.I., S.P.); Special Research Program
(SFB) of the Austrian Science Fund (FWF) F7814-B\r\n(L.B.S., S.P., E.M.T); Austrian
Science Fund (FWF) 10.55776/COE16 (L.B.S., Y.I., E.M.T.);\r\nAustrian Academy of
Sciences DOC Fellowship 27229 (S.P.); ERC Advanced Grant 742046\r\n(E.M.T.); NIH
award R24 OD031956 (L.P.); and in part by the Intramural Research\r\nProgram of
the National Institutes of Health (NIH) through 1ZIA NS003153 to A.J.L.\r\nThe contributions
of the NIH author are considered Works of the United States\r\nGovernment. The findings
and conclusions presented in this paper are those of\r\nthe authors and do not necessarily
reflect the views of the NIH or the U.S. Department\r\nof Health and Human Services. "
article_processing_charge: No
author:
- first_name: Yuri
full_name: Ignatyev, Yuri
last_name: Ignatyev
- first_name: Stavros
full_name: Papadopoulos, Stavros
id: 40606b92-f128-11eb-9611-bf66a98cfa5c
last_name: Papadopoulos
- first_name: Mateja
full_name: Soretić, Mateja
last_name: Soretić
- first_name: Jake
full_name: Yeung, Jake
id: 123012b2-db30-11eb-b4d8-a35840c0551b
last_name: Yeung
orcid: 0000-0003-1732-1559
- first_name: Tzi-Yang
full_name: Lin, Tzi-Yang
last_name: Lin
- first_name: Elly M
full_name: Tanaka, Elly M
last_name: Tanaka
- first_name: Leonid
full_name: Peshkin, Leonid
last_name: Peshkin
- first_name: Ariel J
full_name: Levine, Ariel J
last_name: Levine
- first_name: Mariano I
full_name: Gabitto, Mariano I
last_name: Gabitto
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Ignatyev Y, Papadopoulos S, Soretić M, et al. Innovations in spinal cord cell
type heterogeneity across vertebrate evolution. bioRxiv. doi:10.1101/2025.10.09.680955
apa: Ignatyev, Y., Papadopoulos, S., Soretić, M., Yeung, J., Lin, T.-Y., Tanaka,
E. M., … Sweeney, L. B. (n.d.). Innovations in spinal cord cell type heterogeneity
across vertebrate evolution. bioRxiv. https://doi.org/10.1101/2025.10.09.680955
chicago: Ignatyev, Yuri, Stavros Papadopoulos, Mateja Soretić, Jake Yeung, Tzi-Yang
Lin, Elly M Tanaka, Leonid Peshkin, Ariel J Levine, Mariano I Gabitto, and Lora
B. Sweeney. “Innovations in Spinal Cord Cell Type Heterogeneity across Vertebrate
Evolution.” BioRxiv, n.d. https://doi.org/10.1101/2025.10.09.680955.
ieee: Y. Ignatyev et al., “Innovations in spinal cord cell type heterogeneity
across vertebrate evolution,” bioRxiv. .
ista: Ignatyev Y, Papadopoulos S, Soretić M, Yeung J, Lin T-Y, Tanaka EM, Peshkin
L, Levine AJ, Gabitto MI, Sweeney LB. Innovations in spinal cord cell type heterogeneity
across vertebrate evolution. bioRxiv, 10.1101/2025.10.09.680955.
mla: Ignatyev, Yuri, et al. “Innovations in Spinal Cord Cell Type Heterogeneity
across Vertebrate Evolution.” BioRxiv, doi:10.1101/2025.10.09.680955.
short: Y. Ignatyev, S. Papadopoulos, M. Soretić, J. Yeung, T.-Y. Lin, E.M. Tanaka,
L. Peshkin, A.J. Levine, M.I. Gabitto, L.B. Sweeney, BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-05-27T06:54:04Z
date_published: 2025-10-11T00:00:00Z
date_updated: 2026-05-27T07:25:41Z
day: '11'
department:
- _id: LoSw
- _id: ScienComp
doi: 10.1101/2025.10.09.680955
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.10.09.680955
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
grant_number: '101041551'
name: Development and Evolution of Tetrapod Motor Circuits
- _id: 907b765e-16d5-11f0-9cad-fef108a945b1
grant_number: '27229'
name: 'A Tale of Two Circuits: Rostrocaudal spinal cord patterning during the swim-to-limb
transition of Xenopus metamorphosis'
publication: bioRxiv
publication_status: submitted
status: public
title: Innovations in spinal cord cell type heterogeneity across vertebrate evolution
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2025'
...