---
OA_place: publisher
_id: '8353'
abstract:
- lang: eng
text: "Mrp (Multi resistance and pH adaptation) are broadly distributed secondary
active antiporters that catalyze the transport of monovalent ions such as sodium
and potassium outside of the cell coupled to the inward translocation of protons.
Mrp antiporters are unique in a way that they are composed of seven subunits (MrpABCDEFG)
encoded in a single operon, whereas other antiporters catalyzing the same reaction
are mostly encoded by a single gene. Mrp exchangers are crucial for intracellular
pH homeostasis and Na+ efflux, essential mechanisms for H+ uptake under alkaline
environments and for reduction of the intracellular concentration of toxic cations.
Mrp displays no homology to any other monovalent Na+(K+)/H+ antiporters but Mrp
subunits have primary sequence similarity to essential redox-driven proton pumps,
such as respiratory complex I and membrane-bound hydrogenases. This similarity
reinforces the hypothesis that these present day redox-driven proton pumps are
descended from the Mrp antiporter. The Mrp structure serves as a model to understand
the yet obscure coupling mechanism between ion or electron transfer and proton
translocation in this large group of proteins. In the thesis, I am presenting
the purification, biochemical analysis, cryo-EM analysis and molecular structure
of the Mrp complex from Anoxybacillus flavithermus solved by cryo-EM at 3.0 Å
resolution. Numerous conditions were screened to purify Mrp to high homogeneity
and to obtain an appropriate distribution of single particles on cryo-EM grids
covered with a continuous layer of ultrathin carbon. A preferred particle orientation
problem was solved by performing a tilted data collection. The activity assays
showed the specific pH-dependent\r\nprofile of secondary active antiporters. The
molecular structure shows that Mrp is a dimer of seven-subunit protomers with
50 trans-membrane helices each. The dimer interface is built by many short and
tilted transmembrane helices, probably causing a thinning of the bacterial membrane.
The surface charge distribution shows an extraordinary asymmetry within each monomer,
revealing presumable proton and sodium translocation pathways. The two largest\r\nand
homologous Mrp subunits MrpA and MrpD probably translocate one proton each into
the cell. The sodium ion is likely being translocated in the opposite direction
within the small subunits along a ladder of charged and conserved residues. Based
on the structure, we propose a mechanism were the antiport activity is accomplished
via electrostatic interactions between the charged cations and key charged residues.
The flexible key TM helices coordinate these\r\nelectrostatic interactions, while
the membrane thinning between the monomers enables the translocation of sodium
across the charged membrane. The entire family of redox-driven proton pumps is
likely to perform their mechanism in a likewise manner."
acknowledged_ssus:
- _id: LifeSc
- _id: EM-Fac
- _id: ScienComp
acknowledgement: "I acknowledge the scientific service units of the IST Austria for
providing resources by the Life Science Facility, the Electron Microscopy Facility
and the high-performance computer cluster. Special thanks to the cryo-EM specialists
Valentin Hodirnau and Daniel Johann Gütl for spending many hours with me in front
of the microscope and for supporting me to collect the data presented here. I also
want to thank Professor Masahiro Ito for providing plasmid DNA\r\nencoding Mrp from
Anoxybacillus flavithermus WK1. I am a recipient of a DOC Fellowship of the Austrian
Academy of Sciences."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Julia
full_name: Steiner, Julia
id: 3BB67EB0-F248-11E8-B48F-1D18A9856A87
last_name: Steiner
orcid: 0000-0003-0493-3775
citation:
ama: Steiner J. Biochemical and structural investigation of the Mrp antiporter,
an ancestor of complex I. 2020. doi:10.15479/AT:ISTA:8353
apa: Steiner, J. (2020). Biochemical and structural investigation of the Mrp
antiporter, an ancestor of complex I. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8353
chicago: Steiner, Julia. “Biochemical and Structural Investigation of the Mrp Antiporter,
an Ancestor of Complex I.” Institute of Science and Technology Austria, 2020.
https://doi.org/10.15479/AT:ISTA:8353.
ieee: J. Steiner, “Biochemical and structural investigation of the Mrp antiporter,
an ancestor of complex I,” Institute of Science and Technology Austria, 2020.
ista: Steiner J. 2020. Biochemical and structural investigation of the Mrp antiporter,
an ancestor of complex I. Institute of Science and Technology Austria.
mla: Steiner, Julia. Biochemical and Structural Investigation of the Mrp Antiporter,
an Ancestor of Complex I. Institute of Science and Technology Austria, 2020,
doi:10.15479/AT:ISTA:8353.
short: J. Steiner, Biochemical and Structural Investigation of the Mrp Antiporter,
an Ancestor of Complex I, Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-09-09T14:27:01Z
date_published: 2020-09-09T00:00:00Z
date_updated: 2026-04-08T07:23:36Z
day: '09'
ddc:
- '572'
degree_awarded: PhD
department:
- _id: LeSa
doi: 10.15479/AT:ISTA:8353
file:
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checksum: 2388d7e6e7a4d364c096fa89f305c3de
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file_name: Thesis_Julia_Steiner.docx
file_size: 223328668
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has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: None
page: '191'
project:
- _id: 26169496-B435-11E9-9278-68D0E5697425
grant_number: '24741'
name: Revealing the functional mechanism of Mrp antiporter, an ancestor of complex
I
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8284'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
title: Biochemical and structural investigation of the Mrp antiporter, an ancestor
of complex I
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
OA_place: publisher
_id: '8366'
abstract:
- lang: eng
text: "Fabrication of curved shells plays an important role in modern design, industry,
and science. Among their remarkable properties are, for example, aesthetics of
organic shapes, ability to evenly distribute loads, or efficient flow separation.
They find applications across vast length scales ranging from sky-scraper architecture
to microscopic devices. But, at\r\nthe same time, the design of curved shells
and their manufacturing process pose a variety of challenges. In this thesis,
they are addressed from several perspectives. In particular, this thesis presents
approaches based on the transformation of initially flat sheets into the target
curved surfaces. This involves problems of interactive design of shells with nontrivial
mechanical constraints, inverse design of complex structural materials, and data-driven
modeling of delicate and time-dependent physical properties. At the same time,
two newly-developed self-morphing mechanisms targeting flat-to-curved transformation
are presented.\r\nIn architecture, doubly curved surfaces can be realized as cold
bent glass panelizations. Originally flat glass panels are bent into frames and
remain stressed. This is a cost-efficient fabrication approach compared to hot
bending, when glass panels are shaped plastically. However such constructions
are prone to breaking during bending, and it is highly\r\nnontrivial to navigate
the design space, keeping the panels fabricable and aesthetically pleasing at
the same time. We introduce an interactive design system for cold bent glass façades,
while previously even offline optimization for such scenarios has not been sufficiently
developed. Our method is based on a deep learning approach providing quick\r\nand
high precision estimation of glass panel shape and stress while handling the shape\r\nmultimodality.\r\nFabrication
of smaller objects of scales below 1 m, can also greatly benefit from shaping
originally flat sheets. In this respect, we designed new self-morphing shell mechanisms
transforming from an initial flat state to a doubly curved state with high precision
and detail. Our so-called CurveUps demonstrate the encodement of the geometric
information\r\ninto the shell. Furthermore, we explored the frontiers of programmable
materials and showed how temporal information can additionally be encoded into
a flat shell. This allows prescribing deformation sequences for doubly curved
surfaces and, thus, facilitates self-collision avoidance enabling complex shapes
and functionalities otherwise impossible.\r\nBoth of these methods include inverse
design tools keeping the user in the design loop."
acknowledged_ssus:
- _id: M-Shop
- _id: ScienComp
acknowledgement: "During the work on this thesis, I received substantial support from
IST Austria’s scientific service units. A big thank you to Todor Asenov and other
Miba Machine Shop team members for their help with fabrication of experimental prototypes.
In addition, I would like to thank Scientific Computing team for the support with
high performance computing.\r\nFinancial support was provided by the European Research
Council (ERC) under grant agreement No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented
Computational Design and Modeling, which I gratefully acknowledge."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: 'Guseinov R. Computational design of curved thin shells: From glass façades
to programmable matter. 2020. doi:10.15479/AT:ISTA:8366'
apa: 'Guseinov, R. (2020). Computational design of curved thin shells: From glass
façades to programmable matter. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:8366'
chicago: 'Guseinov, Ruslan. “Computational Design of Curved Thin Shells: From Glass
Façades to Programmable Matter.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:8366.'
ieee: 'R. Guseinov, “Computational design of curved thin shells: From glass façades
to programmable matter,” Institute of Science and Technology Austria, 2020.'
ista: 'Guseinov R. 2020. Computational design of curved thin shells: From glass
façades to programmable matter. Institute of Science and Technology Austria.'
mla: 'Guseinov, Ruslan. Computational Design of Curved Thin Shells: From Glass
Façades to Programmable Matter. Institute of Science and Technology Austria,
2020, doi:10.15479/AT:ISTA:8366.'
short: 'R. Guseinov, Computational Design of Curved Thin Shells: From Glass Façades
to Programmable Matter, Institute of Science and Technology Austria, 2020.'
corr_author: '1'
date_created: 2020-09-10T16:19:55Z
date_published: 2020-09-21T00:00:00Z
date_updated: 2026-04-08T07:25:22Z
day: '21'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8366
ec_funded: 1
file:
- access_level: open_access
checksum: f8da89553da36037296b0a80f14ebf50
content_type: application/pdf
creator: rguseino
date_created: 2020-09-10T16:11:49Z
date_updated: 2020-09-10T16:11:49Z
file_id: '8367'
file_name: thesis_rguseinov.pdf
file_size: 70950442
relation: main_file
success: 1
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creator: rguseino
date_created: 2020-09-11T09:39:48Z
date_updated: 2020-09-16T15:11:01Z
file_id: '8374'
file_name: thesis_source.zip
file_size: 76207597
relation: source_file
file_date_updated: 2020-09-16T15:11:01Z
fulldoi: https://doi.org/10.15479/AT:ISTA:8366
has_accepted_license: '1'
keyword:
- computer-aided design
- shape modeling
- self-morphing
- mechanical engineering
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '118'
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication_identifier:
isbn:
- 978-3-99078-010-7
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8562'
relation: part_of_dissertation
status: public
- id: '8375'
relation: research_data
status: public
- id: '7151'
relation: research_data
status: deleted
- id: '1001'
relation: part_of_dissertation
status: public
- id: '7262'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
title: 'Computational design of curved thin shells: From glass façades to programmable
matter'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '8384'
abstract:
- lang: eng
text: Previous research on animations of soap bubbles, films, and foams largely
focuses on the motion and geometric shape of the bubble surface. These works neglect
the evolution of the bubble’s thickness, which is normally responsible for visual
phenomena like surface vortices, Newton’s interference patterns, capillary waves,
and deformation-dependent rupturing of films in a foam. In this paper, we model
these natural phenomena by introducing the film thickness as a reduced degree
of freedom in the Navier-Stokes equations and deriving their equations of motion.
We discretize the equations on a nonmanifold triangle mesh surface and couple
it to an existing bubble solver. In doing so, we also introduce an incompressible
fluid solver for 2.5D films and a novel advection algorithm for convecting fields
across non-manifold surface junctions. Our simulations enhance state-of-the-art
bubble solvers with additional effects caused by convection, rippling, draining,
and evaporation of the thin film.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We wish to thank the anonymous reviewers and the members of the
Visual Computing Group at IST Austria for their valuable feedback, especially Camille
Schreck for her help in rendering. This research was supported by the Scientific
Service Units (SSU) of IST Austria through resources provided by Scientific Computing.
We would like to thank the authors of [Belcour and Barla 2017] for providing their
implementation, the authors of [Atkins and Elliott 2010] and [Seychelles et al.
2008] for allowing us to use their results, and Rok Grah for helpful discussions.
Finally, we thank Ryoichi Ando for many discussions from the beginning of the project
that resulted in important contents of the paper including our formulation, numerical
scheme, and initial implementation. This project has received funding from the\r\nEuropean
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
programme under grant agreement No. 638176."
article_number: '31'
article_processing_charge: No
article_type: original
author:
- first_name: Sadashige
full_name: Ishida, Sadashige
id: 6F7C4B96-A8E9-11E9-A7CA-09ECE5697425
last_name: Ishida
orcid: 0000-0002-3121-3100
- first_name: Peter
full_name: Synak, Peter
id: 331776E2-F248-11E8-B48F-1D18A9856A87
last_name: Synak
- first_name: Fumiya
full_name: Narita, Fumiya
last_name: Narita
- first_name: Toshiya
full_name: Hachisuka, Toshiya
last_name: Hachisuka
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Ishida S, Synak P, Narita F, Hachisuka T, Wojtan C. A model for soap film dynamics
with evolving thickness. ACM Transactions on Graphics. 2020;39(4). doi:10.1145/3386569.3392405
apa: Ishida, S., Synak, P., Narita, F., Hachisuka, T., & Wojtan, C. (2020).
A model for soap film dynamics with evolving thickness. ACM Transactions on
Graphics. Association for Computing Machinery. https://doi.org/10.1145/3386569.3392405
chicago: Ishida, Sadashige, Peter Synak, Fumiya Narita, Toshiya Hachisuka, and Chris
Wojtan. “A Model for Soap Film Dynamics with Evolving Thickness.” ACM Transactions
on Graphics. Association for Computing Machinery, 2020. https://doi.org/10.1145/3386569.3392405.
ieee: S. Ishida, P. Synak, F. Narita, T. Hachisuka, and C. Wojtan, “A model for
soap film dynamics with evolving thickness,” ACM Transactions on Graphics,
vol. 39, no. 4. Association for Computing Machinery, 2020.
ista: Ishida S, Synak P, Narita F, Hachisuka T, Wojtan C. 2020. A model for soap
film dynamics with evolving thickness. ACM Transactions on Graphics. 39(4), 31.
mla: Ishida, Sadashige, et al. “A Model for Soap Film Dynamics with Evolving Thickness.”
ACM Transactions on Graphics, vol. 39, no. 4, 31, Association for Computing
Machinery, 2020, doi:10.1145/3386569.3392405.
short: S. Ishida, P. Synak, F. Narita, T. Hachisuka, C. Wojtan, ACM Transactions
on Graphics 39 (2020).
date_created: 2020-09-13T22:01:18Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2026-04-16T08:29:36Z
day: '08'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/3386569.3392405
ec_funded: 1
external_id:
isi:
- '000583700300004'
file:
- access_level: open_access
checksum: 813831ca91319d794d9748c276b24578
content_type: application/pdf
creator: dernst
date_created: 2020-11-23T09:03:19Z
date_updated: 2020-11-23T09:03:19Z
file_id: '8795'
file_name: 2020_soapfilm_submitted.pdf
file_size: 14935529
relation: main_file
success: 1
file_date_updated: 2020-11-23T09:03:19Z
fulldoi: https://doi.org/10.1145/3386569.3392405
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/3386569.3392405
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '19630'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: A model for soap film dynamics with evolving thickness
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 39
year: '2020'
...
---
_id: '8385'
abstract:
- lang: eng
text: 'We present a method for animating yarn-level cloth effects using a thin-shell
solver. We accomplish this through numerical homogenization: we first use a large
number of yarn-level simulations to build a model of the potential energy density
of the cloth, and then use this energy density function to compute forces in a
thin shell simulator. We model several yarn-based materials, including both woven
and knitted fabrics. Our model faithfully reproduces expected effects like the
stiffness of woven fabrics, and the highly deformable nature and anisotropy of
knitted fabrics. Our approach does not require any real-world experiments nor
measurements; because the method is based entirely on simulations, it can generate
entirely new material models quickly, without the need for testing apparatuses
or human intervention. We provide data-driven models of several woven and knitted
fabrics, which can be used for efficient simulation with an off-the-shelf cloth
solver.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We wish to thank the anonymous reviewers and the members of the
Visual Computing Group at IST Austria for their valuable feedback. We also thank
the creators of the Berkeley Garment Library [de Joya et al. 2012] for providing
garment meshes, [Krishnamurthy and Levoy 1996] and [Turk and Levoy 1994] for the
armadillo and bunny meshes, the creators of libWetCloth [Fei et al. 2018] for their
implementation of discrete elastic rod forces, and Tomáš Skřivan for\r\ninspiring
discussions and help with Mathematica code generation. This research was supported
by the Scientific Service Units (SSU) of IST Austria through resources provided
by Scientific Computing. This project has received funding from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
under grant agreement No. 638176. Rahul Narain is supported by a Pankaj Gupta Young
Faculty Fellowship and a gift from Adobe Inc."
article_number: '48'
article_processing_charge: No
article_type: original
author:
- first_name: Georg
full_name: Sperl, Georg
id: 4DD40360-F248-11E8-B48F-1D18A9856A87
last_name: Sperl
- first_name: Rahul
full_name: Narain, Rahul
last_name: Narain
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Sperl G, Narain R, Wojtan C. Homogenized yarn-level cloth. ACM Transactions
on Graphics. 2020;39(4). doi:10.1145/3386569.3392412
apa: Sperl, G., Narain, R., & Wojtan, C. (2020). Homogenized yarn-level cloth.
ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3386569.3392412
chicago: Sperl, Georg, Rahul Narain, and Chris Wojtan. “Homogenized Yarn-Level Cloth.”
ACM Transactions on Graphics. Association for Computing Machinery, 2020.
https://doi.org/10.1145/3386569.3392412.
ieee: G. Sperl, R. Narain, and C. Wojtan, “Homogenized yarn-level cloth,” ACM
Transactions on Graphics, vol. 39, no. 4. Association for Computing Machinery,
2020.
ista: Sperl G, Narain R, Wojtan C. 2020. Homogenized yarn-level cloth. ACM Transactions
on Graphics. 39(4), 48.
mla: Sperl, Georg, et al. “Homogenized Yarn-Level Cloth.” ACM Transactions on
Graphics, vol. 39, no. 4, 48, Association for Computing Machinery, 2020, doi:10.1145/3386569.3392412.
short: G. Sperl, R. Narain, C. Wojtan, ACM Transactions on Graphics 39 (2020).
corr_author: '1'
date_created: 2020-09-13T22:01:18Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2026-04-16T08:31:55Z
day: '08'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/3386569.3392412
ec_funded: 1
external_id:
isi:
- '000583700300021'
file:
- access_level: open_access
checksum: cf4c1d361c3196c4bd424520a5588205
content_type: application/pdf
creator: dernst
date_created: 2020-11-23T09:01:22Z
date_updated: 2020-11-23T09:01:22Z
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file_name: 2020_hylc_submitted.pdf
file_size: 38922662
relation: main_file
success: 1
file_date_updated: 2020-11-23T09:01:22Z
fulldoi: https://doi.org/10.1145/3386569.3392412
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/3386569.3392412
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '12358'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Homogenized yarn-level cloth
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 39
year: '2020'
...
---
OA_place: publisher
_id: '8390'
abstract:
- lang: eng
text: "Deep neural networks have established a new standard for data-dependent feature
extraction pipelines in the Computer Vision literature. Despite their remarkable
performance in the standard supervised learning scenario, i.e. when models are
trained with labeled data and tested on samples that follow a similar distribution,
neural networks have been shown to struggle with more advanced generalization
abilities, such as transferring knowledge across visually different domains, or
generalizing to new unseen combinations of known concepts. In this thesis we argue
that, in contrast to the usual black-box behavior of neural networks, leveraging
more structured internal representations is a promising direction\r\nfor tackling
such problems. In particular, we focus on two forms of structure. First, we tackle
modularity: We show that (i) compositional architectures are a natural tool for
modeling reasoning tasks, in that they efficiently capture their combinatorial
nature, which is key for generalizing beyond the compositions seen during training.
We investigate how to to learn such models, both formally and experimentally,
for the task of abstract visual reasoning. Then, we show that (ii) in some settings,
modularity allows us to efficiently break down complex tasks into smaller, easier,
modules, thereby improving computational efficiency; We study this behavior in
the context of generative models for colorization, as well as for small objects
detection. Secondly, we investigate the inherently layered structure of representations
learned by neural networks, and analyze its role in the context of transfer learning
and domain adaptation across visually\r\ndissimilar domains. "
acknowledged_ssus:
- _id: CampIT
- _id: ScienComp
acknowledgement: Last but not least, I would like to acknowledge the support of the
IST IT and scientific computing team for helping provide a great work environment.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Amélie
full_name: Royer, Amélie
id: 3811D890-F248-11E8-B48F-1D18A9856A87
last_name: Royer
orcid: 0000-0002-8407-0705
citation:
ama: Royer A. Leveraging structure in Computer Vision tasks for flexible Deep Learning
models. 2020. doi:10.15479/AT:ISTA:8390
apa: Royer, A. (2020). Leveraging structure in Computer Vision tasks for flexible
Deep Learning models. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8390
chicago: Royer, Amélie. “Leveraging Structure in Computer Vision Tasks for Flexible
Deep Learning Models.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8390.
ieee: A. Royer, “Leveraging structure in Computer Vision tasks for flexible Deep
Learning models,” Institute of Science and Technology Austria, 2020.
ista: Royer A. 2020. Leveraging structure in Computer Vision tasks for flexible
Deep Learning models. Institute of Science and Technology Austria.
mla: Royer, Amélie. Leveraging Structure in Computer Vision Tasks for Flexible
Deep Learning Models. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8390.
short: A. Royer, Leveraging Structure in Computer Vision Tasks for Flexible Deep
Learning Models, Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-09-14T13:42:09Z
date_published: 2020-09-14T00:00:00Z
date_updated: 2026-04-08T07:26:44Z
day: '14'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: ChLa
doi: 10.15479/AT:ISTA:8390
file:
- access_level: open_access
checksum: c914d2f88846032f3d8507734861b6ee
content_type: application/pdf
creator: dernst
date_created: 2020-09-14T13:39:14Z
date_updated: 2020-09-14T13:39:14Z
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file_name: 2020_Thesis_Royer.pdf
file_size: 30224591
relation: main_file
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checksum: ae98fb35d912cff84a89035ae5794d3c
content_type: application/x-zip-compressed
creator: dernst
date_created: 2020-09-14T13:39:17Z
date_updated: 2020-09-14T13:39:17Z
file_id: '8392'
file_name: thesis_sources.zip
file_size: 74227627
relation: main_file
file_date_updated: 2020-09-14T13:39:17Z
fulldoi: https://doi.org/10.15479/AT:ISTA:8390
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '09'
oa: 1
oa_version: Published Version
page: '197'
publication_identifier:
isbn:
- 978-3-99078-007-7
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7936'
relation: part_of_dissertation
status: public
- id: '8092'
relation: part_of_dissertation
status: public
- id: '911'
relation: part_of_dissertation
status: public
- id: '8193'
relation: part_of_dissertation
status: public
- id: '7937'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
title: Leveraging structure in Computer Vision tasks for flexible Deep Learning models
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '8535'
abstract:
- lang: eng
text: We propose a method to enhance the visual detail of a water surface simulation.
Our method works as a post-processing step which takes a simulation as input and
increases its apparent resolution by simulating many detailed Lagrangian water
waves on top of it. We extend linear water wave theory to work in non-planar domains
which deform over time, and we discretize the theory using Lagrangian wave packets
attached to spline curves. The method is numerically stable and trivially parallelizable,
and it produces high frequency ripples with dispersive wave-like behaviors customized
to the underlying fluid simulation.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We wish to thank the anonymous reviewers and the members of the Visual
Computing Group at IST Austria for their valuable feedback. This research was supported
by the Scientific Service Units (SSU) of IST Austria through resources provided
by Scientific Computing. This project has received funding from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
under grant agreement No. 638176 and Marie SkłodowskaCurie Grant Agreement No. 665385.
article_number: '65'
article_processing_charge: No
article_type: original
author:
- first_name: Tomas
full_name: Skrivan, Tomas
id: 486A5A46-F248-11E8-B48F-1D18A9856A87
last_name: Skrivan
- first_name: Andreas
full_name: Soderstrom, Andreas
last_name: Soderstrom
- first_name: John
full_name: Johansson, John
last_name: Johansson
- first_name: Christoph
full_name: Sprenger, Christoph
last_name: Sprenger
- first_name: Ken
full_name: Museth, Ken
last_name: Museth
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: 'Skrivan T, Soderstrom A, Johansson J, Sprenger C, Museth K, Wojtan C. Wave
curves: Simulating Lagrangian water waves on dynamically deforming surfaces. ACM
Transactions on Graphics. 2020;39(4). doi:10.1145/3386569.3392466'
apa: 'Skrivan, T., Soderstrom, A., Johansson, J., Sprenger, C., Museth, K., &
Wojtan, C. (2020). Wave curves: Simulating Lagrangian water waves on dynamically
deforming surfaces. ACM Transactions on Graphics. Association for Computing
Machinery. https://doi.org/10.1145/3386569.3392466'
chicago: 'Skrivan, Tomas, Andreas Soderstrom, John Johansson, Christoph Sprenger,
Ken Museth, and Chris Wojtan. “Wave Curves: Simulating Lagrangian Water Waves
on Dynamically Deforming Surfaces.” ACM Transactions on Graphics. Association
for Computing Machinery, 2020. https://doi.org/10.1145/3386569.3392466.'
ieee: 'T. Skrivan, A. Soderstrom, J. Johansson, C. Sprenger, K. Museth, and C. Wojtan,
“Wave curves: Simulating Lagrangian water waves on dynamically deforming surfaces,”
ACM Transactions on Graphics, vol. 39, no. 4. Association for Computing
Machinery, 2020.'
ista: 'Skrivan T, Soderstrom A, Johansson J, Sprenger C, Museth K, Wojtan C. 2020.
Wave curves: Simulating Lagrangian water waves on dynamically deforming surfaces.
ACM Transactions on Graphics. 39(4), 65.'
mla: 'Skrivan, Tomas, et al. “Wave Curves: Simulating Lagrangian Water Waves on
Dynamically Deforming Surfaces.” ACM Transactions on Graphics, vol. 39,
no. 4, 65, Association for Computing Machinery, 2020, doi:10.1145/3386569.3392466.'
short: T. Skrivan, A. Soderstrom, J. Johansson, C. Sprenger, K. Museth, C. Wojtan,
ACM Transactions on Graphics 39 (2020).
corr_author: '1'
date_created: 2020-09-20T22:01:37Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2026-04-16T08:26:38Z
day: '08'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/3386569.3392466
ec_funded: 1
external_id:
isi:
- '000583700300038'
file:
- access_level: open_access
checksum: c3a680893f01cc4a9e961ff0a4cfa12f
content_type: application/pdf
creator: dernst
date_created: 2020-09-21T07:51:44Z
date_updated: 2020-09-21T07:51:44Z
file_id: '8541'
file_name: 2020_ACM_Skrivan.pdf
file_size: 20223953
relation: main_file
success: 1
file_date_updated: 2020-09-21T07:51:44Z
fulldoi: https://doi.org/10.1145/3386569.3392466
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Wave curves: Simulating Lagrangian water waves on dynamically deforming surfaces'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 39
year: '2020'
...
---
_id: '8562'
abstract:
- lang: eng
text: "Cold bent glass is a promising and cost-efficient method for realizing doubly
curved glass facades. They are produced by attaching planar glass sheets to curved
frames and require keeping the occurring stress within safe limits.\r\nHowever,
it is very challenging to navigate the design space of cold bent glass panels
due to the fragility of the material, which impedes the form-finding for practically
feasible and aesthetically pleasing cold bent glass facades. We propose an interactive,
data-driven approach for designing cold bent glass facades that can be seamlessly
integrated into a typical architectural design pipeline. Our method allows non-expert
users to interactively edit a parametric surface while providing real-time feedback
on the deformed shape and maximum stress of cold bent glass panels. Designs are
automatically refined to minimize several fairness criteria while maximal stresses
are kept within glass limits. We achieve interactive frame rates by using a differentiable
Mixture Density Network trained from more than a million simulations. Given a
curved boundary, our regression model is capable of handling multistable\r\nconfigurations
and accurately predicting the equilibrium shape of the panel and its corresponding
maximal stress. We show predictions are highly accurate and validate our results
with a physical realization of a cold bent glass surface."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank IST Austria’s Scientific Computing team for their support,
Corinna Datsiou and Sophie Pennetier for their expert input on the practical applications
of cold bent glass, and Zaha Hadid Architects and Waagner Biro for providing the
architectural datasets. Photo of Fondation Louis Vuitton by Francisco Anzola / CC
BY 2.0 / cropped.\r\nPhoto of Opus by Danica O. Kus. This project has received funding
from the European Union’s\r\nHorizon 2020 research and innovation program under
grant agreement No 675789 - Algebraic Representations in Computer-Aided Design for
complEx Shapes (ARCADES), from the European Research Council (ERC) under grant agreement
No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented Computational Design
and Modeling, and SFB-Transregio “Discretization in Geometry and Dynamics” through
grant I 2978 of the Austrian Science Fund (FWF). F. Rist and K. Gavriil have been
partially supported by KAUST baseline funding."
article_number: '208'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Konstantinos
full_name: Gavriil, Konstantinos
last_name: Gavriil
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- first_name: Jesus
full_name: Perez Rodriguez, Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- first_name: Davide
full_name: Pellis, Davide
last_name: Pellis
- first_name: Paul M
full_name: Henderson, Paul M
id: 13C09E74-18D9-11E9-8878-32CFE5697425
last_name: Henderson
orcid: 0000-0002-5198-7445
- first_name: Florian
full_name: Rist, Florian
last_name: Rist
- first_name: Helmut
full_name: Pottmann, Helmut
last_name: Pottmann
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: Gavriil K, Guseinov R, Perez Rodriguez J, et al. Computational design of cold
bent glass façades. ACM Transactions on Graphics. 2020;39(6). doi:10.1145/3414685.3417843
apa: Gavriil, K., Guseinov, R., Perez Rodriguez, J., Pellis, D., Henderson, P. M.,
Rist, F., … Bickel, B. (2020). Computational design of cold bent glass façades.
ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3414685.3417843
chicago: Gavriil, Konstantinos, Ruslan Guseinov, Jesus Perez Rodriguez, Davide Pellis,
Paul M Henderson, Florian Rist, Helmut Pottmann, and Bernd Bickel. “Computational
Design of Cold Bent Glass Façades.” ACM Transactions on Graphics. Association
for Computing Machinery, 2020. https://doi.org/10.1145/3414685.3417843.
ieee: K. Gavriil et al., “Computational design of cold bent glass façades,”
ACM Transactions on Graphics, vol. 39, no. 6. Association for Computing
Machinery, 2020.
ista: Gavriil K, Guseinov R, Perez Rodriguez J, Pellis D, Henderson PM, Rist F,
Pottmann H, Bickel B. 2020. Computational design of cold bent glass façades. ACM
Transactions on Graphics. 39(6), 208.
mla: Gavriil, Konstantinos, et al. “Computational Design of Cold Bent Glass Façades.”
ACM Transactions on Graphics, vol. 39, no. 6, 208, Association for Computing
Machinery, 2020, doi:10.1145/3414685.3417843.
short: K. Gavriil, R. Guseinov, J. Perez Rodriguez, D. Pellis, P.M. Henderson, F.
Rist, H. Pottmann, B. Bickel, ACM Transactions on Graphics 39 (2020).
corr_author: '1'
date_created: 2020-09-23T11:30:02Z
date_published: 2020-11-26T00:00:00Z
date_updated: 2026-04-08T07:25:22Z
day: '26'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3414685.3417843
ec_funded: 1
external_id:
arxiv:
- '2009.03667'
isi:
- '000595589100048'
file:
- access_level: open_access
checksum: c7f67717ad74e670b7daeae732abe151
content_type: application/pdf
creator: bbickel
date_created: 2023-05-23T20:54:43Z
date_updated: 2023-05-23T20:54:43Z
file_id: '13084'
file_name: coldglass.pdf
file_size: 28964641
relation: main_file
success: 1
file_date_updated: 2023-05-23T20:54:43Z
fulldoi: https://doi.org/10.1145/3414685.3417843
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/bend-dont-break/
record:
- id: '8761'
relation: research_data
status: public
- id: '8366'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Computational design of cold bent glass façades
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 39
year: '2020'
...
---
_id: '8581'
abstract:
- lang: eng
text: The majority of adenosine triphosphate (ATP) powering cellular processes in
eukaryotes is produced by the mitochondrial F1Fo ATP synthase. Here, we present
the atomic models of the membrane Fo domain and the entire mammalian (ovine) F1Fo,
determined by cryo-electron microscopy. Subunits in the membrane domain are arranged
in the ‘proton translocation cluster’ attached to the c-ring and a more distant
‘hook apparatus’ holding subunit e. Unexpectedly, this subunit is anchored to
a lipid ‘plug’ capping the c-ring. We present a detailed proton translocation
pathway in mammalian Fo and key inter-monomer contacts in F1Fo multimers. Cryo-EM
maps of F1Fo exposed to calcium reveal a retracted subunit e and a disassembled
c-ring, suggesting permeability transition pore opening. We propose a model for
the permeability transition pore opening, whereby subunit e pulls the lipid plug
out of the c-ring. Our structure will allow the design of drugs for many emerging
applications in medicine.
acknowledged_ssus:
- _id: EM-Fac
- _id: ScienComp
acknowledgement: We thank J. Novacek from CEITEC (Brno, Czech Republic) for assistance
with collecting the FEI Krios dataset and iNEXT for providing access to CEITEC.
We thank the IST Austria EM facility for access and assistance with collecting the
FEI Glacios dataset. Data processing was performed at the IST high-performance computing
cluster. This work has been supported by iNEXT EM HEDC (proposal 4506), funded by
the Horizon 2020 Programme of the European Commission.
article_processing_charge: No
article_type: original
author:
- first_name: Gergely
full_name: Pinke, Gergely
id: 4D5303E6-F248-11E8-B48F-1D18A9856A87
last_name: Pinke
- first_name: Long
full_name: Zhou, Long
id: 3E751364-F248-11E8-B48F-1D18A9856A87
last_name: Zhou
orcid: 0000-0002-1864-8951
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Pinke G, Zhou L, Sazanov LA. Cryo-EM structure of the entire mammalian F-type
ATP synthase. Nature Structural and Molecular Biology. 2020;27(11):1077-1085.
doi:10.1038/s41594-020-0503-8
apa: Pinke, G., Zhou, L., & Sazanov, L. A. (2020). Cryo-EM structure of the
entire mammalian F-type ATP synthase. Nature Structural and Molecular Biology.
Springer Nature. https://doi.org/10.1038/s41594-020-0503-8
chicago: Pinke, Gergely, Long Zhou, and Leonid A Sazanov. “Cryo-EM Structure of
the Entire Mammalian F-Type ATP Synthase.” Nature Structural and Molecular
Biology. Springer Nature, 2020. https://doi.org/10.1038/s41594-020-0503-8.
ieee: G. Pinke, L. Zhou, and L. A. Sazanov, “Cryo-EM structure of the entire mammalian
F-type ATP synthase,” Nature Structural and Molecular Biology, vol. 27,
no. 11. Springer Nature, pp. 1077–1085, 2020.
ista: Pinke G, Zhou L, Sazanov LA. 2020. Cryo-EM structure of the entire mammalian
F-type ATP synthase. Nature Structural and Molecular Biology. 27(11), 1077–1085.
mla: Pinke, Gergely, et al. “Cryo-EM Structure of the Entire Mammalian F-Type ATP
Synthase.” Nature Structural and Molecular Biology, vol. 27, no. 11, Springer
Nature, 2020, pp. 1077–85, doi:10.1038/s41594-020-0503-8.
short: G. Pinke, L. Zhou, L.A. Sazanov, Nature Structural and Molecular Biology
27 (2020) 1077–1085.
date_created: 2020-09-28T08:59:27Z
date_published: 2020-11-01T00:00:00Z
date_updated: 2025-07-10T11:57:09Z
day: '01'
department:
- _id: LeSa
doi: 10.1038/s41594-020-0503-8
external_id:
isi:
- '000569299400004'
pmid:
- '32929284'
fulldoi: https://doi.org/10.1038/s41594-020-0503-8
intvolume: ' 27'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1077-1085
pmid: 1
publication: Nature Structural and Molecular Biology
publication_identifier:
eissn:
- 1545-9985
issn:
- 1545-9993
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/structure-of-atpase-solved/
scopus_import: '1'
status: public
title: Cryo-EM structure of the entire mammalian F-type ATP synthase
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2020'
...
---
_id: '8724'
abstract:
- lang: eng
text: "We study the problem of learning from multiple untrusted data sources, a
scenario of increasing practical relevance given the recent emergence of crowdsourcing
and collaborative learning paradigms. Specifically, we analyze the situation in
which a learning system obtains datasets from multiple sources, some of which
might be biased or even adversarially perturbed. It is\r\nknown that in the single-source
case, an adversary with the power to corrupt a fixed fraction of the training
data can prevent PAC-learnability, that is, even in the limit of infinitely much
training data, no learning system can approach the optimal test error. In this
work we show that, surprisingly, the same is not true in the multi-source setting,
where the adversary can arbitrarily\r\ncorrupt a fixed fraction of the data sources.
Our main results are a generalization bound that provides finite-sample guarantees
for this learning setting, as well as corresponding lower bounds. Besides establishing
PAC-learnability our results also show that in a cooperative learning setting
sharing data with other parties has provable benefits, even if some\r\nparticipants
are malicious. "
acknowledged_ssus:
- _id: ScienComp
acknowledgement: Dan Alistarh is supported in part by the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No 805223 ScaleML). This research was supported by the Scientific
Service Units (SSU) of IST Austria through resources provided by Scientific Computing
(SciComp).
article_processing_charge: No
arxiv: 1
author:
- first_name: Nikola H
full_name: Konstantinov, Nikola H
id: 4B9D76E4-F248-11E8-B48F-1D18A9856A87
last_name: Konstantinov
orcid: 0009-0009-5204-7621
- first_name: Elias
full_name: Frantar, Elias
id: 09a8f98d-ec99-11ea-ae11-c063a7b7fe5f
last_name: Frantar
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Konstantinov NH, Frantar E, Alistarh D-A, Lampert C. On the sample complexity
of adversarial multi-source PAC learning. In: Proceedings of the 37th International
Conference on Machine Learning. Vol 119. ML Research Press; 2020:5416-5425.'
apa: 'Konstantinov, N. H., Frantar, E., Alistarh, D.-A., & Lampert, C. (2020).
On the sample complexity of adversarial multi-source PAC learning. In Proceedings
of the 37th International Conference on Machine Learning (Vol. 119, pp. 5416–5425).
Online: ML Research Press.'
chicago: Konstantinov, Nikola H, Elias Frantar, Dan-Adrian Alistarh, and Christoph
Lampert. “On the Sample Complexity of Adversarial Multi-Source PAC Learning.”
In Proceedings of the 37th International Conference on Machine Learning,
119:5416–25. ML Research Press, 2020.
ieee: N. H. Konstantinov, E. Frantar, D.-A. Alistarh, and C. Lampert, “On the sample
complexity of adversarial multi-source PAC learning,” in Proceedings of the
37th International Conference on Machine Learning, Online, 2020, vol. 119,
pp. 5416–5425.
ista: 'Konstantinov NH, Frantar E, Alistarh D-A, Lampert C. 2020. On the sample
complexity of adversarial multi-source PAC learning. Proceedings of the 37th International
Conference on Machine Learning. ICML: International Conference on Machine Learning
vol. 119, 5416–5425.'
mla: Konstantinov, Nikola H., et al. “On the Sample Complexity of Adversarial Multi-Source
PAC Learning.” Proceedings of the 37th International Conference on Machine
Learning, vol. 119, ML Research Press, 2020, pp. 5416–25.
short: N.H. Konstantinov, E. Frantar, D.-A. Alistarh, C. Lampert, in:, Proceedings
of the 37th International Conference on Machine Learning, ML Research Press, 2020,
pp. 5416–5425.
conference:
end_date: 2020-07-18
location: Online
name: 'ICML: International Conference on Machine Learning'
start_date: 2020-07-12
corr_author: '1'
date_created: 2020-11-05T15:25:58Z
date_published: 2020-07-12T00:00:00Z
date_updated: 2026-04-07T14:19:48Z
day: '12'
ddc:
- '000'
department:
- _id: DaAl
- _id: ChLa
ec_funded: 1
external_id:
arxiv:
- '2002.10384'
file:
- access_level: open_access
checksum: cc755d0054bc4b2be778ea7aa7884d2f
content_type: application/pdf
creator: dernst
date_created: 2021-02-15T09:00:01Z
date_updated: 2021-02-15T09:00:01Z
file_id: '9120'
file_name: 2020_PMLR_Konstantinov.pdf
file_size: 281286
relation: main_file
success: 1
file_date_updated: 2021-02-15T09:00:01Z
has_accepted_license: '1'
intvolume: ' 119'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 5416-5425
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the 37th International Conference on Machine Learning
publication_identifier:
issn:
- 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
link:
- relation: supplementary_material
url: http://proceedings.mlr.press/v119/konstantinov20a/konstantinov20a-supp.pdf
record:
- id: '10799'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: On the sample complexity of adversarial multi-source PAC learning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2020'
...
---
_id: '8761'
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: Guseinov R. Supplementary data for “Computational design of cold bent glass
façades.” 2020. doi:10.15479/AT:ISTA:8761
apa: Guseinov, R. (2020). Supplementary data for “Computational design of cold bent
glass façades.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8761
chicago: Guseinov, Ruslan. “Supplementary Data for ‘Computational Design of Cold
Bent Glass Façades.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8761.
ieee: R. Guseinov, “Supplementary data for ‘Computational design of cold bent glass
façades.’” Institute of Science and Technology Austria, 2020.
ista: Guseinov R. 2020. Supplementary data for ‘Computational design of cold bent
glass façades’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8761.
mla: Guseinov, Ruslan. Supplementary Data for “Computational Design of Cold Bent
Glass Façades.” Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8761.
short: R. Guseinov, (2020).
contributor:
- contributor_type: researcher
first_name: Konstantinos
last_name: Gavriil
- contributor_type: researcher
first_name: Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- contributor_type: researcher
first_name: Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- contributor_type: researcher
first_name: Davide
last_name: Pellis
- contributor_type: researcher
first_name: Paul M
id: 13C09E74-18D9-11E9-8878-32CFE5697425
last_name: Henderson
orcid: 0000-0002-5198-7445
- contributor_type: researcher
first_name: Florian
last_name: Rist
- contributor_type: researcher
first_name: Helmut
last_name: Pottmann
- contributor_type: researcher
first_name: Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
corr_author: '1'
date_created: 2020-11-16T10:47:18Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2025-04-15T07:16:12Z
day: '23'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8761
ec_funded: 1
file:
- access_level: open_access
checksum: f5ae57b97017b9f61081032703361233
content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:31:29Z
date_updated: 2020-11-16T10:31:29Z
file_id: '8762'
file_name: mdn_model.tar.gz
file_size: 15378270
relation: main_file
success: 1
- access_level: open_access
checksum: b0d25e04060ee78c585ee2f23542c744
content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:43:23Z
date_updated: 2020-11-16T10:43:23Z
file_id: '8763'
file_name: optimal_panels_data.tar.gz
file_size: 615387734
relation: main_file
success: 1
- access_level: open_access
checksum: 69c1dde3434ada86d125e0c2588caf1e
content_type: text/plain
creator: rguseino
date_created: 2020-11-18T10:04:59Z
date_updated: 2020-11-18T10:04:59Z
file_id: '8770'
file_name: readme.txt
file_size: 1228
relation: main_file
success: 1
file_date_updated: 2020-11-18T10:04:59Z
fulldoi: https://doi.org/10.15479/AT:ISTA:8761
has_accepted_license: '1'
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publisher: Institute of Science and Technology Austria
related_material:
link:
- relation: software
url: https://github.com/russelmann/cold-glass-acm
record:
- id: '8562'
relation: used_in_publication
status: public
status: public
title: Supplementary data for "Computational design of cold bent glass façades"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8765'
abstract:
- lang: eng
text: This paper introduces a simple method for simulating highly anisotropic elastoplastic
material behaviors like the dissolution of fibrous phenomena (splintering wood,
shredding bales of hay) and materials composed of large numbers of irregularly‐shaped
bodies (piles of twigs, pencils, or cards). We introduce a simple transformation
of the anisotropic problem into an equivalent isotropic one, and we solve this
new “fictitious” isotropic problem using an existing simulator based on the material
point method. Our approach results in minimal changes to existing simulators,
and it allows us to re‐use popular isotropic plasticity models like the Drucker‐Prager
yield criterion instead of inventing new anisotropic plasticity models for every
phenomenon we wish to simulate.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We wish to thank the anonymous reviewers and the members of the
Visual Computing Group at IST Austria for their valuable feedback. This research
was supported by the Scientific Service Units (SSU) of IST Austria through resources
provided by Scientific Computing. We would also like to thank Joseph Teran and Chenfanfu
Jiang for the helpful discussions.\r\nThis project has received funding from the
European Research Council (ERC) under the European Union's Horizon 2020 research
and innovation programme under grant agreement No. 638176."
article_processing_charge: No
article_type: original
author:
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Schreck C, Wojtan C. A practical method for animating anisotropic elastoplastic
materials. Computer Graphics Forum. 2020;39(2):89-99. doi:10.1111/cgf.13914
apa: Schreck, C., & Wojtan, C. (2020). A practical method for animating anisotropic
elastoplastic materials. Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.13914
chicago: Schreck, Camille, and Chris Wojtan. “A Practical Method for Animating Anisotropic
Elastoplastic Materials.” Computer Graphics Forum. Wiley, 2020. https://doi.org/10.1111/cgf.13914.
ieee: C. Schreck and C. Wojtan, “A practical method for animating anisotropic elastoplastic
materials,” Computer Graphics Forum, vol. 39, no. 2. Wiley, pp. 89–99,
2020.
ista: Schreck C, Wojtan C. 2020. A practical method for animating anisotropic elastoplastic
materials. Computer Graphics Forum. 39(2), 89–99.
mla: Schreck, Camille, and Chris Wojtan. “A Practical Method for Animating Anisotropic
Elastoplastic Materials.” Computer Graphics Forum, vol. 39, no. 2, Wiley,
2020, pp. 89–99, doi:10.1111/cgf.13914.
short: C. Schreck, C. Wojtan, Computer Graphics Forum 39 (2020) 89–99.
date_created: 2020-11-17T09:35:10Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2024-10-22T09:58:14Z
day: '01'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1111/cgf.13914
ec_funded: 1
external_id:
isi:
- '000548709600008'
file:
- access_level: open_access
checksum: 7605f605acd84d0942b48bc7a1c2d72e
content_type: application/pdf
creator: dernst
date_created: 2020-11-23T09:05:13Z
date_updated: 2020-11-23T09:05:13Z
file_id: '8796'
file_name: 2020_poff_revisited.pdf
file_size: 38969122
relation: main_file
success: 1
file_date_updated: 2020-11-23T09:05:13Z
fulldoi: https://doi.org/10.1111/cgf.13914
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '2'
keyword:
- Computer Networks and Communications
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 89-99
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A practical method for animating anisotropic elastoplastic materials
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 39
year: '2020'
...
---
_id: '8971'
abstract:
- lang: eng
text: The actin-related protein (Arp)2/3 complex nucleates branched actin filament
networks pivotal for cell migration, endocytosis and pathogen infection. Its activation
is tightly regulated and involves complex structural rearrangements and actin
filament binding, which are yet to be understood. Here, we report a 9.0 Å resolution
structure of the actin filament Arp2/3 complex branch junction in cells using
cryo-electron tomography and subtomogram averaging. This allows us to generate
an accurate model of the active Arp2/3 complex in the branch junction and its
interaction with actin filaments. Notably, our model reveals a previously undescribed
set of interactions of the Arp2/3 complex with the mother filament, significantly
different to the previous branch junction model. Our structure also indicates
a central role for the ArpC3 subunit in stabilizing the active conformation.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: "This research was supported by the Scientific Service Units (SSUs)
of IST Austria through resources provided by Scientific Computing (SciComp), the
Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy
Facility (EMF). We also thank Dimitry Tegunov (MPI for Biophysical Chemistry) for
helpful discussions\r\nabout the M software, and Michael Sixt (IST Austria) and
Klemens Rottner (Technical University Braunschweig, HZI Braunschweig) for critical
reading of the manuscript. We also thank Gregory Voth (University of Chicago) for
providing us the MD-derived branch junction model for comparison. The authors acknowledge
support from IST Austria and from the Austrian Science Fund (FWF): M02495 to G.D.
and Austrian Science Fund (FWF): P33367 to F.K.M.S. "
article_number: '6437'
article_processing_charge: No
article_type: original
author:
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Victor-Valentin
full_name: Hodirnau, Victor-Valentin
id: 3661B498-F248-11E8-B48F-1D18A9856A87
last_name: Hodirnau
orcid: 0000-0003-3904-947X
- first_name: William
full_name: Wan, William
last_name: Wan
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. Cryo-electron tomography
structure of Arp2/3 complex in cells reveals new insights into the branch junction.
Nature Communications. 2020;11. doi:10.1038/s41467-020-20286-x
apa: Fäßler, F., Dimchev, G. A., Hodirnau, V.-V., Wan, W., & Schur, F. K. (2020).
Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights
into the branch junction. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-020-20286-x
chicago: Fäßler, Florian, Georgi A Dimchev, Victor-Valentin Hodirnau, William Wan,
and Florian KM Schur. “Cryo-Electron Tomography Structure of Arp2/3 Complex in
Cells Reveals New Insights into the Branch Junction.” Nature Communications.
Springer Nature, 2020. https://doi.org/10.1038/s41467-020-20286-x.
ieee: F. Fäßler, G. A. Dimchev, V.-V. Hodirnau, W. Wan, and F. K. Schur, “Cryo-electron
tomography structure of Arp2/3 complex in cells reveals new insights into the
branch junction,” Nature Communications, vol. 11. Springer Nature, 2020.
ista: Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. 2020. Cryo-electron tomography
structure of Arp2/3 complex in cells reveals new insights into the branch junction.
Nature Communications. 11, 6437.
mla: Fäßler, Florian, et al. “Cryo-Electron Tomography Structure of Arp2/3 Complex
in Cells Reveals New Insights into the Branch Junction.” Nature Communications,
vol. 11, 6437, Springer Nature, 2020, doi:10.1038/s41467-020-20286-x.
short: F. Fäßler, G.A. Dimchev, V.-V. Hodirnau, W. Wan, F.K. Schur, Nature Communications
11 (2020).
corr_author: '1'
date_created: 2020-12-23T08:25:45Z
date_published: 2020-12-22T00:00:00Z
date_updated: 2025-04-15T07:52:12Z
day: '22'
ddc:
- '570'
department:
- _id: FlSc
- _id: EM-Fac
doi: 10.1038/s41467-020-20286-x
external_id:
isi:
- '000603078000003'
file:
- access_level: open_access
checksum: 55d43ea0061cc4027ba45e966e1db8cc
content_type: application/pdf
creator: dernst
date_created: 2020-12-28T08:16:10Z
date_updated: 2020-12-28T08:16:10Z
file_id: '8975'
file_name: 2020_NatureComm_Faessler.pdf
file_size: 3958727
relation: main_file
success: 1
file_date_updated: 2020-12-28T08:16:10Z
fulldoi: https://doi.org/10.1038/s41467-020-20286-x
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- General Physics and Astronomy
- General Chemistry
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
- _id: 2674F658-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02495
name: Protein structure and function in filopodia across scales
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/cutting-edge-technology-reveals-structures-within-cells/
scopus_import: '1'
status: public
title: Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights
into the branch junction
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...
---
_id: '7464'
abstract:
- lang: eng
text: 'Retrovirus assembly is driven by the multidomain structural protein Gag.
Interactions between the capsid domains (CA) of Gag result in Gag multimerization,
leading to an immature virus particle that is formed by a protein lattice based
on dimeric, trimeric, and hexameric protein contacts. Among retroviruses the inter-
and intra-hexamer contacts differ, especially in the N-terminal sub-domain of
CA (CANTD). For HIV-1 the cellular molecule inositol hexakisphosphate (IP6) interacts
with and stabilizes the immature hexamer, and is required for production of infectious
virus particles. We have used in vitro assembly, cryo-electron tomography and
subtomogram averaging, atomistic molecular dynamics simulations and mutational
analyses to study the HIV-related lentivirus equine infectious anemia virus (EIAV).
In particular, we sought to understand the structural conservation of the immature
lentivirus lattice and the role of IP6 in EIAV assembly. Similar to HIV-1, IP6
strongly promoted in vitro assembly of EIAV Gag proteins into virus-like particles
(VLPs), which took three morphologically highly distinct forms: narrow tubes,
wide tubes, and spheres. Structural characterization of these VLPs to sub-4Å resolution
unexpectedly showed that all three morphologies are based on an immature lattice
with preserved key structural components, highlighting the structural versatility
of CA to form immature assemblies. A direct comparison between EIAV and HIV revealed
that both lentiviruses maintain similar immature interfaces, which are established
by both conserved and non-conserved residues. In both EIAV and HIV-1, IP6 regulates
immature assembly via conserved lysine residues within the CACTD and SP. Lastly,
we demonstrate that IP6 stimulates in vitro assembly of immature particles of
several other retroviruses in the lentivirus genus, suggesting a conserved role
for IP6 in lentiviral assembly.'
acknowledged_ssus:
- _id: ScienComp
article_number: e1008277
article_processing_charge: No
article_type: original
author:
- first_name: Robert A.
full_name: Dick, Robert A.
last_name: Dick
- first_name: Chaoyi
full_name: Xu, Chaoyi
last_name: Xu
- first_name: Dustin R.
full_name: Morado, Dustin R.
last_name: Morado
- first_name: Vladyslav
full_name: Kravchuk, Vladyslav
id: 4D62F2A6-F248-11E8-B48F-1D18A9856A87
last_name: Kravchuk
orcid: 0000-0001-9523-9089
- first_name: Clifton L.
full_name: Ricana, Clifton L.
last_name: Ricana
- first_name: Terri D.
full_name: Lyddon, Terri D.
last_name: Lyddon
- first_name: Arianna M.
full_name: Broad, Arianna M.
last_name: Broad
- first_name: J. Ryan
full_name: Feathers, J. Ryan
last_name: Feathers
- first_name: Marc C.
full_name: Johnson, Marc C.
last_name: Johnson
- first_name: Volker M.
full_name: Vogt, Volker M.
last_name: Vogt
- first_name: Juan R.
full_name: Perilla, Juan R.
last_name: Perilla
- first_name: John A. G.
full_name: Briggs, John A. G.
last_name: Briggs
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Dick RA, Xu C, Morado DR, et al. Structures of immature EIAV Gag lattices reveal
a conserved role for IP6 in lentivirus assembly. PLOS Pathogens. 2020;16(1).
doi:10.1371/journal.ppat.1008277
apa: Dick, R. A., Xu, C., Morado, D. R., Kravchuk, V., Ricana, C. L., Lyddon, T.
D., … Schur, F. K. (2020). Structures of immature EIAV Gag lattices reveal a conserved
role for IP6 in lentivirus assembly. PLOS Pathogens. Public Library of
Science. https://doi.org/10.1371/journal.ppat.1008277
chicago: Dick, Robert A., Chaoyi Xu, Dustin R. Morado, Vladyslav Kravchuk, Clifton
L. Ricana, Terri D. Lyddon, Arianna M. Broad, et al. “Structures of Immature EIAV
Gag Lattices Reveal a Conserved Role for IP6 in Lentivirus Assembly.” PLOS
Pathogens. Public Library of Science, 2020. https://doi.org/10.1371/journal.ppat.1008277.
ieee: R. A. Dick et al., “Structures of immature EIAV Gag lattices reveal
a conserved role for IP6 in lentivirus assembly,” PLOS Pathogens, vol.
16, no. 1. Public Library of Science, 2020.
ista: Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers
JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FK. 2020. Structures of
immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.
PLOS Pathogens. 16(1), e1008277.
mla: Dick, Robert A., et al. “Structures of Immature EIAV Gag Lattices Reveal a
Conserved Role for IP6 in Lentivirus Assembly.” PLOS Pathogens, vol. 16,
no. 1, e1008277, Public Library of Science, 2020, doi:10.1371/journal.ppat.1008277.
short: R.A. Dick, C. Xu, D.R. Morado, V. Kravchuk, C.L. Ricana, T.D. Lyddon, A.M.
Broad, J.R. Feathers, M.C. Johnson, V.M. Vogt, J.R. Perilla, J.A.G. Briggs, F.K.
Schur, PLOS Pathogens 16 (2020).
corr_author: '1'
date_created: 2020-02-06T18:47:17Z
date_published: 2020-01-27T00:00:00Z
date_updated: 2025-04-15T08:24:51Z
day: '27'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1371/journal.ppat.1008277
external_id:
isi:
- '000510746400010'
pmid:
- '31986188'
file:
- access_level: open_access
checksum: a297f54d1fef0efe4789ca00f37f241e
content_type: application/pdf
creator: dernst
date_created: 2020-02-11T10:07:28Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7484'
file_name: 2020_PLOSPatho_Dick.pdf
file_size: 4551246
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intvolume: ' 16'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26736D6A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31445
name: Structural conservation and diversity in retroviral capsid
publication: PLOS Pathogens
publication_identifier:
issn:
- 1553-7374
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '9723'
relation: research_data
status: deleted
scopus_import: '1'
status: public
title: Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in
lentivirus assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '8586'
abstract:
- lang: eng
text: Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights
into biological processes and structures within a native context. However, a major
challenge still lies in the efficient and reproducible preparation of adherent
cells for subsequent cryo-EM analysis. This is due to the sensitivity of many
cellular specimens to the varying seeding and culturing conditions required for
EM experiments, the often limited amount of cellular material and also the fragility
of EM grids and their substrate. Here, we present low-cost and reusable 3D printed
grid holders, designed to improve specimen preparation when culturing challenging
cellular samples directly on grids. The described grid holders increase cell culture
reproducibility and throughput, and reduce the resources required for cell culturing.
We show that grid holders can be integrated into various cryo-EM workflows, including
micro-patterning approaches to control cell seeding on grids, and for generating
samples for cryo-focused ion beam milling and cryo-electron tomography experiments.
Their adaptable design allows for the generation of specialized grid holders customized
to a large variety of applications.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: This work was supported by the Austrian Science Fund (FWF, P33367)
to FKMS. BZ acknowledges support by the Niederösterreich Fond. This research was
also supported by the Scientific Service Units (SSU) of IST Austria through resources
provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the
BioImaging Facility (BIF) and the Electron Microscopy Facility (EMF). We thank Georgi
Dimchev (IST Austria) and Sonja Jacob (Vienna Biocenter Core Facilities) for testing
our grid holders in different experimental setups and Daniel Gütl and the Kondrashov
group (IST Austria) for granting us repeated access to their 3D printers. We also
thank Jonna Alanko and the Sixt lab (IST Austria) for providing us HeLa cells, primary
BL6 mouse tail fibroblasts, NIH 3T3 fibroblasts and human telomerase immortalised
foreskin fibroblasts for our experiments. We are thankful to Ori Avinoam and William
Wan for helpful comments on the manuscript and also thank Dorotea Fracchiolla (Art&Science)
for illustrating the graphical abstract.
article_number: '107633'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Fäßler F, Zens B, Hauschild R, Schur FK. 3D printed cell culture grid holders
for improved cellular specimen preparation in cryo-electron microscopy. Journal
of Structural Biology. 2020;212(3). doi:10.1016/j.jsb.2020.107633
apa: Fäßler, F., Zens, B., Hauschild, R., & Schur, F. K. (2020). 3D printed
cell culture grid holders for improved cellular specimen preparation in cryo-electron
microscopy. Journal of Structural Biology. Elsevier. https://doi.org/10.1016/j.jsb.2020.107633
chicago: Fäßler, Florian, Bettina Zens, Robert Hauschild, and Florian KM Schur.
“3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation
in Cryo-Electron Microscopy.” Journal of Structural Biology. Elsevier,
2020. https://doi.org/10.1016/j.jsb.2020.107633.
ieee: F. Fäßler, B. Zens, R. Hauschild, and F. K. Schur, “3D printed cell culture
grid holders for improved cellular specimen preparation in cryo-electron microscopy,”
Journal of Structural Biology, vol. 212, no. 3. Elsevier, 2020.
ista: Fäßler F, Zens B, Hauschild R, Schur FK. 2020. 3D printed cell culture grid
holders for improved cellular specimen preparation in cryo-electron microscopy.
Journal of Structural Biology. 212(3), 107633.
mla: Fäßler, Florian, et al. “3D Printed Cell Culture Grid Holders for Improved
Cellular Specimen Preparation in Cryo-Electron Microscopy.” Journal of Structural
Biology, vol. 212, no. 3, 107633, Elsevier, 2020, doi:10.1016/j.jsb.2020.107633.
short: F. Fäßler, B. Zens, R. Hauschild, F.K. Schur, Journal of Structural Biology
212 (2020).
corr_author: '1'
date_created: 2020-09-29T13:24:06Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2026-10-17T22:30:03Z
day: '01'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1016/j.jsb.2020.107633
external_id:
isi:
- '000600997800008'
pmid:
- '32987119'
file:
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checksum: c48cbf594e84fc2f91966ffaafc0918c
content_type: application/pdf
creator: dernst
date_created: 2020-12-10T14:01:10Z
date_updated: 2020-12-10T14:01:10Z
file_id: '8937'
file_name: 2020_JourStrucBiology_Faessler.pdf
file_size: 7076870
relation: main_file
success: 1
file_date_updated: 2020-12-10T14:01:10Z
fulldoi: https://doi.org/10.1016/j.jsb.2020.107633
has_accepted_license: '1'
intvolume: ' 212'
isi: 1
issue: '3'
keyword:
- electron microscopy
- cryo-EM
- EM sample preparation
- 3D printing
- cell culture
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: NÖ-Fonds Preis für die Jungforscherin des Jahres am IST Austria
publication: Journal of Structural Biology
publication_identifier:
issn:
- 1047-8477
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '14592'
relation: used_in_publication
status: public
- id: '12491'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 3D printed cell culture grid holders for improved cellular specimen preparation
in cryo-electron microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 212
year: '2020'
...
---
_id: '6418'
abstract:
- lang: eng
text: Males and females of Artemia franciscana, a crustacean commonly used in the
aquarium trade, are highly dimorphic. Sex is determined by a pair of ZW chromosomes,
but the nature and extent of differentiation of these chromosomes is unknown.
Here, we characterize the Z chromosome by detecting genomic regions that show
lower genomic coverage in female than in male samples, and regions that harbor
an excess of female-specific SNPs. We detect many Z-specific genes, which no longer
have homologs on the W, but also Z-linked genes that appear to have diverged very
recently from their existing W-linked homolog. We assess patterns of male and
female expression in two tissues with extensive morphological dimorphism, gonads,
and heads. In agreement with their morphology, sex-biased expression is common
in both tissues. Interestingly, the Z chromosome is not enriched for sex-biased
genes, and seems to in fact have a mechanism of dosage compensation that leads
to equal expression in males and in females. Both of these patterns are contrary
to most ZW systems studied so far, making A. franciscana an excellent model for
investigating the interplay between the evolution of sexual dimorphism and dosage
compensation, as well as Z chromosome evolution in general.
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Ann K
full_name: Huylmans, Ann K
id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
last_name: Huylmans
orcid: 0000-0001-8871-4961
- first_name: Melissa A
full_name: Toups, Melissa A
id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
last_name: Toups
orcid: 0000-0002-9752-7380
- first_name: Ariana
full_name: Macon, Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: William J
full_name: Gammerdinger, William J
id: 3A7E01BC-F248-11E8-B48F-1D18A9856A87
last_name: Gammerdinger
orcid: 0000-0001-9638-1220
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. Sex-biased gene
expression and dosage compensation on the Artemia franciscana Z-chromosome. Genome
biology and evolution. 2019;11(4):1033-1044. doi:10.1093/gbe/evz053
apa: Huylmans, A. K., Toups, M. A., Macon, A., Gammerdinger, W. J., & Vicoso,
B. (2019). Sex-biased gene expression and dosage compensation on the Artemia franciscana
Z-chromosome. Genome Biology and Evolution. Oxford University Press. https://doi.org/10.1093/gbe/evz053
chicago: Huylmans, Ann K, Melissa A Toups, Ariana Macon, William J Gammerdinger,
and Beatriz Vicoso. “Sex-Biased Gene Expression and Dosage Compensation on the
Artemia Franciscana Z-Chromosome.” Genome Biology and Evolution. Oxford
University Press, 2019. https://doi.org/10.1093/gbe/evz053.
ieee: A. K. Huylmans, M. A. Toups, A. Macon, W. J. Gammerdinger, and B. Vicoso,
“Sex-biased gene expression and dosage compensation on the Artemia franciscana
Z-chromosome,” Genome biology and evolution, vol. 11, no. 4. Oxford University
Press, pp. 1033–1044, 2019.
ista: Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. 2019. Sex-biased
gene expression and dosage compensation on the Artemia franciscana Z-chromosome.
Genome biology and evolution. 11(4), 1033–1044.
mla: Huylmans, Ann K., et al. “Sex-Biased Gene Expression and Dosage Compensation
on the Artemia Franciscana Z-Chromosome.” Genome Biology and Evolution,
vol. 11, no. 4, Oxford University Press, 2019, pp. 1033–44, doi:10.1093/gbe/evz053.
short: A.K. Huylmans, M.A. Toups, A. Macon, W.J. Gammerdinger, B. Vicoso, Genome
Biology and Evolution 11 (2019) 1033–1044.
date_created: 2019-05-13T07:58:38Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2025-04-14T07:41:21Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evz053
ec_funded: 1
external_id:
isi:
- '000476569800003'
file:
- access_level: open_access
checksum: 7d0ede297b6741f3dc89cd59017c7642
content_type: application/pdf
creator: dernst
date_created: 2019-05-14T08:29:38Z
date_updated: 2020-07-14T12:47:29Z
file_id: '6446'
file_name: 2019_GBE_Huylmans.pdf
file_size: 1256303
relation: main_file
file_date_updated: 2020-07-14T12:47:29Z
fulldoi: https://doi.org/10.1093/gbe/evz053
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1033-1044
project:
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: Genome biology and evolution
publication_identifier:
eissn:
- 1759-6653
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
record:
- id: '6060'
relation: popular_science
status: public
scopus_import: '1'
status: public
title: Sex-biased gene expression and dosage compensation on the Artemia franciscana
Z-chromosome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2019'
...
---
_id: '6442'
abstract:
- lang: eng
text: This paper investigates the use of fundamental solutions for animating detailed
linear water surface waves. We first propose an analytical solution for efficiently
animating circular ripples in closed form. We then show how to adapt the method
of fundamental solutions (MFS) to create ambient waves interacting with complex
obstacles. Subsequently, we present a novel wavelet-based discretization which
outperforms the state of the art MFS approach for simulating time-varying water
surface waves with moving obstacles. Our results feature high-resolution spatial
details, interactions with complex boundaries, and large open ocean domains. Our
method compares favorably with previous work as well as known analytical solutions.
We also present comparisons between our method and real world examples.
acknowledged_ssus:
- _id: ScienComp
article_number: '130'
article_processing_charge: No
author:
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Christian
full_name: Hafner, Christian
id: 400429CC-F248-11E8-B48F-1D18A9856A87
last_name: Hafner
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Schreck C, Hafner C, Wojtan C. Fundamental solutions for water wave animation.
ACM Transactions on Graphics. 2019;38(4). doi:10.1145/3306346.3323002
apa: Schreck, C., Hafner, C., & Wojtan, C. (2019). Fundamental solutions for
water wave animation. ACM Transactions on Graphics. ACM. https://doi.org/10.1145/3306346.3323002
chicago: Schreck, Camille, Christian Hafner, and Chris Wojtan. “Fundamental Solutions
for Water Wave Animation.” ACM Transactions on Graphics. ACM, 2019. https://doi.org/10.1145/3306346.3323002.
ieee: C. Schreck, C. Hafner, and C. Wojtan, “Fundamental solutions for water wave
animation,” ACM Transactions on Graphics, vol. 38, no. 4. ACM, 2019.
ista: Schreck C, Hafner C, Wojtan C. 2019. Fundamental solutions for water wave
animation. ACM Transactions on Graphics. 38(4), 130.
mla: Schreck, Camille, et al. “Fundamental Solutions for Water Wave Animation.”
ACM Transactions on Graphics, vol. 38, no. 4, 130, ACM, 2019, doi:10.1145/3306346.3323002.
short: C. Schreck, C. Hafner, C. Wojtan, ACM Transactions on Graphics 38 (2019).
date_created: 2019-05-14T07:04:06Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2024-10-22T09:58:22Z
day: '01'
ddc:
- '000'
- '005'
department:
- _id: ChWo
doi: 10.1145/3306346.3323002
ec_funded: 1
external_id:
isi:
- '000475740600104'
file:
- access_level: open_access
checksum: 1b737dfe3e051aba8f3f4ab1dceda673
content_type: application/pdf
creator: dernst
date_created: 2019-05-14T07:03:55Z
date_updated: 2020-07-14T12:47:30Z
file_id: '6443'
file_name: 2019_ACM_Schreck.pdf
file_size: 44328918
relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
fulldoi: https://doi.org/10.1145/3306346.3323002
has_accepted_license: '1'
intvolume: ' 38'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/new-method-makes-realistic-water-wave-animations-more-efficient/
scopus_import: '1'
status: public
title: Fundamental solutions for water wave animation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 38
year: '2019'
...
---
_id: '6859'
abstract:
- lang: eng
text: V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found
in archaeaand eubacteria, couple ATP hydrolysis or synthesis to proton translocation
across theplasma membrane using the rotary-catalysis mechanism. They belong to
the V-typeATPase family, which differs from the mitochondrial/chloroplast F-type
ATP synthasesin overall architecture. We solved cryo–electron microscopy structures
of the intactThermus thermophilusV/A-ATPase, reconstituted into lipid nanodiscs,
in three rotationalstates and two substates. These structures indicate substantial
flexibility betweenV1and Voin a working enzyme, which results from mechanical
competition between centralshaft rotation and resistance from the peripheral stalks.
We also describedetails of adenosine diphosphate inhibition release, V1-Votorque
transmission, andproton translocation, which are relevant for the entire V-type
ATPase family.
acknowledged_ssus:
- _id: ScienComp
article_number: eaaw9144
article_processing_charge: No
author:
- first_name: Long
full_name: Zhou, Long
id: 3E751364-F248-11E8-B48F-1D18A9856A87
last_name: Zhou
orcid: 0000-0002-1864-8951
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus
thermophilus V/A-type ATPase. Science. 2019;365(6455). doi:10.1126/science.aaw9144
apa: Zhou, L., & Sazanov, L. A. (2019). Structure and conformational plasticity
of the intact Thermus thermophilus V/A-type ATPase. Science. AAAS. https://doi.org/10.1126/science.aaw9144
chicago: Zhou, Long, and Leonid A Sazanov. “Structure and Conformational Plasticity
of the Intact Thermus Thermophilus V/A-Type ATPase.” Science. AAAS, 2019.
https://doi.org/10.1126/science.aaw9144.
ieee: L. Zhou and L. A. Sazanov, “Structure and conformational plasticity of the
intact Thermus thermophilus V/A-type ATPase,” Science, vol. 365, no. 6455.
AAAS, 2019.
ista: Zhou L, Sazanov LA. 2019. Structure and conformational plasticity of the intact
Thermus thermophilus V/A-type ATPase. Science. 365(6455), eaaw9144.
mla: Zhou, Long, and Leonid A. Sazanov. “Structure and Conformational Plasticity
of the Intact Thermus Thermophilus V/A-Type ATPase.” Science, vol. 365,
no. 6455, eaaw9144, AAAS, 2019, doi:10.1126/science.aaw9144.
short: L. Zhou, L.A. Sazanov, Science 365 (2019).
date_created: 2019-09-07T19:04:45Z
date_published: 2019-08-23T00:00:00Z
date_updated: 2023-08-29T07:52:02Z
day: '23'
department:
- _id: LeSa
doi: 10.1126/science.aaw9144
external_id:
isi:
- '000482464000043'
pmid:
- '31439765'
fulldoi: https://doi.org/10.1126/science.aaw9144
intvolume: ' 365'
isi: 1
issue: '6455'
language:
- iso: eng
month: '08'
oa_version: None
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/structure-of-protein-nano-turbine-revealed/
scopus_import: '1'
status: public
title: Structure and conformational plasticity of the intact Thermus thermophilus
V/A-type ATPase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 365
year: '2019'
...
---
_id: '6978'
abstract:
- lang: eng
text: In pipes and channels, the onset of turbulence is initially dominated by localizedtransients, which lead to sustained turbulence through their collective dynamics. In thepresent
work, we study numerically the localized turbulence in pipe flow and elucidate
astate space structure that gives rise to transient chaos. Starting from the basin
boundaryseparating laminar and turbulent flow, we identify transverse homoclinic orbits, thepresence
of which necessitates a homoclinic tangle and chaos. A direct consequence ofthe
homoclinic tangle is the fractal nature of the laminar-turbulent boundary, which
wasconjectured in various earlier studies. By mapping the transverse intersections
between thestable and unstable manifold of a periodic orbit, we identify the gateways
that promote anescape from turbulence.
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
- first_name: Akshunna
full_name: Dogra, Akshunna
last_name: Dogra
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Budanur NB, Dogra A, Hof B. Geometry of transient chaos in streamwise-localized
pipe flow turbulence. Physical Review Fluids. 2019;4(10):102401. doi:10.1103/PhysRevFluids.4.102401
apa: Budanur, N. B., Dogra, A., & Hof, B. (2019). Geometry of transient chaos
in streamwise-localized pipe flow turbulence. Physical Review Fluids. American
Physical Society. https://doi.org/10.1103/PhysRevFluids.4.102401
chicago: Budanur, Nazmi B, Akshunna Dogra, and Björn Hof. “Geometry of Transient
Chaos in Streamwise-Localized Pipe Flow Turbulence.” Physical Review Fluids.
American Physical Society, 2019. https://doi.org/10.1103/PhysRevFluids.4.102401.
ieee: N. B. Budanur, A. Dogra, and B. Hof, “Geometry of transient chaos in streamwise-localized
pipe flow turbulence,” Physical Review Fluids, vol. 4, no. 10. American
Physical Society, p. 102401, 2019.
ista: Budanur NB, Dogra A, Hof B. 2019. Geometry of transient chaos in streamwise-localized
pipe flow turbulence. Physical Review Fluids. 4(10), 102401.
mla: Budanur, Nazmi B., et al. “Geometry of Transient Chaos in Streamwise-Localized
Pipe Flow Turbulence.” Physical Review Fluids, vol. 4, no. 10, American
Physical Society, 2019, p. 102401, doi:10.1103/PhysRevFluids.4.102401.
short: N.B. Budanur, A. Dogra, B. Hof, Physical Review Fluids 4 (2019) 102401.
date_created: 2019-11-04T10:04:01Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2023-08-30T07:20:03Z
day: '01'
department:
- _id: BjHo
doi: 10.1103/PhysRevFluids.4.102401
external_id:
arxiv:
- '1810.02211'
isi:
- '000493510400001'
fulldoi: https://doi.org/10.1103/PhysRevFluids.4.102401
intvolume: ' 4'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1810.02211
month: '10'
oa: 1
oa_version: Preprint
page: '102401'
publication: Physical Review Fluids
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry of transient chaos in streamwise-localized pipe flow turbulence
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2019'
...
---
OA_place: publisher
_id: '6435'
abstract:
- lang: eng
text: "Social insect colonies tend to have numerous members which function together
like a single organism in such harmony that the term ``super-organism'' is often
used. In this analogy the reproductive caste is analogous to the primordial germ\r\ncells
of a metazoan, while the sterile worker caste corresponds to somatic cells. The
worker castes, like tissues, are\r\nin charge of all functions of a living being,
besides reproduction. The establishment of new super-organismal units\r\n(i.e.
new colonies) is accomplished by the co-dependent castes. The term oftentimes
goes beyond a metaphor. We invoke it when we speak about the metabolic rate, thermoregulation,
nutrient regulation and gas exchange of a social insect colony. Furthermore, we
assert that the super-organism has an immune system, and benefits from ``social
immunity''.\r\n\r\nSocial immunity was first summoned by evolutionary biologists
to resolve the apparent discrepancy between the expected high frequency of disease
outbreak amongst numerous, closely related tightly-interacting hosts, living in
stable and microbially-rich environments, against the exceptionally scarce epidemic
accounts in natural populations. Social\r\nimmunity comprises a multi-layer assembly
of behaviours which have evolved to effectively keep the pathogenic enemies of
a colony at bay. The field of social immunity has drawn interest, as it becomes
increasingly urgent to stop\r\nthe collapse of pollinator species and curb the
growth of invasive pests. In the past decade, several mechanisms of\r\nsocial
immune responses have been dissected, but many more questions remain open.\r\n\r\nI
present my work in two experimental chapters. In the first, I use invasive garden
ants (*Lasius neglectus*) to study how pathogen load and its distribution among
nestmates affect the grooming response of the group. Any given group of ants will
carry out the same total grooming work, but will direct their grooming effort
towards individuals\r\ncarrying a relatively higher spore load. Contrary to expectation,
the highest risk of transmission does not stem from grooming highly contaminated
ants, but instead, we suggest that the grooming response likely minimizes spore
loss to the environment, reducing contamination from inadvertent pickup from the
substrate.\r\n\r\nThe second is a comparative developmental approach. I follow
black garden ant queens (*Lasius niger*) and their colonies from mating flight,
through hibernation for a year. Colonies which grow fast from the start, have
a lower chance of survival through hibernation, and those which survive grow at
a lower pace later. This is true for colonies of naive\r\nand challenged queens.
Early pathogen exposure of the queens changes colony dynamics in an unexpected
way: colonies from exposed queens are more likely to grow slowly and recover in
numbers only after they survive hibernation.\r\n\r\nIn addition to the two experimental
chapters, this thesis includes a co-authored published review on organisational\r\nimmunity,
where we enlist the experimental evidence and theoretical framework on which this
hypothesis is built,\r\nidentify the caveats and underline how the field is ripe
to overcome them. In a final chapter, I describe my part in\r\ntwo collaborative
efforts, one to develop an image-based tracker, and the second to develop a classifier
for ant\r\nbehaviour."
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: M-Shop
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
citation:
ama: Casillas Perez BE. Collective defenses of garden ants against a fungal pathogen.
2019. doi:10.15479/AT:ISTA:6435
apa: Casillas Perez, B. E. (2019). Collective defenses of garden ants against
a fungal pathogen. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:6435
chicago: Casillas Perez, Barbara E. “Collective Defenses of Garden Ants against
a Fungal Pathogen.” Institute of Science and Technology Austria, 2019. https://doi.org/10.15479/AT:ISTA:6435.
ieee: B. E. Casillas Perez, “Collective defenses of garden ants against a fungal
pathogen,” Institute of Science and Technology Austria, 2019.
ista: Casillas Perez BE. 2019. Collective defenses of garden ants against a fungal
pathogen. Institute of Science and Technology Austria.
mla: Casillas Perez, Barbara E. Collective Defenses of Garden Ants against a
Fungal Pathogen. Institute of Science and Technology Austria, 2019, doi:10.15479/AT:ISTA:6435.
short: B.E. Casillas Perez, Collective Defenses of Garden Ants against a Fungal
Pathogen, Institute of Science and Technology Austria, 2019.
corr_author: '1'
date_created: 2019-05-13T08:58:35Z
date_published: 2019-05-07T00:00:00Z
date_updated: 2026-04-08T14:02:12Z
day: '07'
ddc:
- '570'
- '006'
- '578'
- '592'
degree_awarded: PhD
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:6435
ec_funded: 1
file:
- access_level: open_access
checksum: 6daf2d2086111aa8fd3fbc919a3e2833
content_type: application/pdf
creator: casillas
date_created: 2019-05-13T09:16:20Z
date_updated: 2021-02-11T11:17:15Z
embargo: 2020-05-08
file_id: '6438'
file_name: tesisDoctoradoBC.pdf
file_size: 3895187
relation: main_file
- access_level: closed
checksum: 3d221aaff7559a7060230a1ff610594f
content_type: application/zip
creator: casillas
date_created: 2019-05-13T09:16:20Z
date_updated: 2020-07-14T12:47:30Z
embargo_to: open_access
file_id: '6439'
file_name: tesisDoctoradoBC.zip
file_size: 7365118
relation: source_file
file_date_updated: 2021-02-11T11:17:15Z
fulldoi: https://doi.org/10.15479/AT:ISTA:6435
has_accepted_license: '1'
keyword:
- Social Immunity
- Sanitary care
- Social Insects
- Organisational Immunity
- Colony development
- Multi-target tracking
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '183'
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1999'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Sylvia M
full_name: Cremer, Sylvia M
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Collective defenses of garden ants against a fungal pathogen
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2019'
...
---
_id: '6848'
abstract:
- lang: eng
text: Proton-translocating transhydrogenase (also known as nicotinamide nucleotide
transhydrogenase (NNT)) is found in the plasma membranes of bacteria and the inner
mitochondrial membranes of eukaryotes. NNT catalyses the transfer of a hydride
between NADH and NADP+, coupled to the translocation of one proton across the
membrane. Its main physiological function is the generation of NADPH, which is
a substrate in anabolic reactions and a regulator of oxidative status; however,
NNT may also fine-tune the Krebs cycle1,2. NNT deficiency causes familial glucocorticoid
deficiency in humans and metabolic abnormalities in mice, similar to those observed
in type II diabetes3,4. The catalytic mechanism of NNT has been proposed to involve
a rotation of around 180° of the entire NADP(H)-binding domain that alternately
participates in hydride transfer and proton-channel gating. However, owing to
the lack of high-resolution structures of intact NNT, the details of this process
remain unclear5,6. Here we present the cryo-electron microscopy structure of intact
mammalian NNT in different conformational states. We show how the NADP(H)-binding
domain opens the proton channel to the opposite sides of the membrane, and we
provide structures of these two states. We also describe the catalytically important
interfaces and linkers between the membrane and the soluble domains and their
roles in nucleotide exchange. These structures enable us to propose a revised
mechanism for a coupling process in NNT that is consistent with a large body of
previous biochemical work. Our results are relevant to the development of currently
unavailable NNT inhibitors, which may have therapeutic potential in ischaemia
reperfusion injury, metabolic syndrome and some cancers7,8,9.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: " We thank R. Thompson, G. Effantin and V.-V. Hodirnau for their
assistance with collecting NADP+, NADPH and apo datasets, respectively. Data processing
was performed at the IST high-performance computing cluster.\r\nThis project has
received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie Grant Agreement no. 665385."
article_processing_charge: No
article_type: letter_note
author:
- first_name: Domen
full_name: Kampjut, Domen
id: 37233050-F248-11E8-B48F-1D18A9856A87
last_name: Kampjut
orcid: 0000-0002-6018-3422
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Kampjut D, Sazanov LA. Structure and mechanism of mitochondrial proton-translocating
transhydrogenase. Nature. 2019;573(7773):291–295. doi:10.1038/s41586-019-1519-2
apa: Kampjut, D., & Sazanov, L. A. (2019). Structure and mechanism of mitochondrial
proton-translocating transhydrogenase. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1519-2
chicago: Kampjut, Domen, and Leonid A Sazanov. “Structure and Mechanism of Mitochondrial
Proton-Translocating Transhydrogenase.” Nature. Springer Nature, 2019.
https://doi.org/10.1038/s41586-019-1519-2.
ieee: D. Kampjut and L. A. Sazanov, “Structure and mechanism of mitochondrial proton-translocating
transhydrogenase,” Nature, vol. 573, no. 7773. Springer Nature, pp. 291–295,
2019.
ista: Kampjut D, Sazanov LA. 2019. Structure and mechanism of mitochondrial proton-translocating
transhydrogenase. Nature. 573(7773), 291–295.
mla: Kampjut, Domen, and Leonid A. Sazanov. “Structure and Mechanism of Mitochondrial
Proton-Translocating Transhydrogenase.” Nature, vol. 573, no. 7773, Springer
Nature, 2019, pp. 291–295, doi:10.1038/s41586-019-1519-2.
short: D. Kampjut, L.A. Sazanov, Nature 573 (2019) 291–295.
date_created: 2019-09-04T06:21:41Z
date_published: 2019-09-12T00:00:00Z
date_updated: 2026-10-17T22:30:55Z
day: '12'
ddc:
- '572'
department:
- _id: LeSa
doi: 10.1038/s41586-019-1519-2
ec_funded: 1
external_id:
isi:
- '000485415400061'
pmid:
- '31462775'
file:
- access_level: open_access
checksum: 52728cda5210a3e9b74cc204e8aed3d5
content_type: application/pdf
creator: lsazanov
date_created: 2020-11-26T16:33:44Z
date_updated: 2020-11-26T16:33:44Z
file_id: '8821'
file_name: Manuscript_final_acc_withFigs_SI_opt_red.pdf
file_size: 3066206
relation: main_file
success: 1
file_date_updated: 2020-11-26T16:33:44Z
fulldoi: https://doi.org/10.1038/s41586-019-1519-2
has_accepted_license: '1'
intvolume: ' 573'
isi: 1
issue: '7773'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 291–295
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/high-end-microscopy-reveals-structure-and-function-of-crucial-metabolic-enzyme/
record:
- id: '8340'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Structure and mechanism of mitochondrial proton-translocating transhydrogenase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 573
year: '2019'
...