[{"author":[{"first_name":"Lucas","full_name":"Barrault, Lucas","id":"4471a8fd-32c1-11ee-a9a4-fb670d398f64","last_name":"Barrault"},{"orcid":"0000-0003-0142-4000","full_name":"Bugnet, Lisa Annabelle","id":"d9edb345-f866-11ec-9b37-d119b5234501","first_name":"Lisa Annabelle","last_name":"Bugnet"},{"full_name":"Mathis, S.","first_name":"S.","last_name":"Mathis"},{"first_name":"J. S.G.","full_name":"Mombarg, J. S.G.","last_name":"Mombarg"}],"status":"public","isi":1,"ddc":["520"],"month":"09","quality_controlled":"1","publication":"Astronomy & Astrophysics","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1051/0004-6361/202555213","article_type":"original","license":"https://creativecommons.org/licenses/by/4.0/","day":"01","file_date_updated":"2025-10-13T07:05:55Z","acknowledgement":"We thank the referee for their comments and suggestions which allowed us to improve the quality of this manuscript. L. Barrault and L. Bugnet gratefully acknowledge support from the European Research Council (ERC) under the Horizon Europe programme (Calcifer; Starting Grant agreement N°101165631). S. Mathis acknowledges support from the PLATO CNES grant at CEA/DAp. S. Mathis and J.S.G. Mombarg acknowledge support from the European Research Council through HORIZON ERC SyG Grant 4D-STAR 101071505. While partially funded by the European Union, views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. L. Barrault thanks T. Van Reeth and C. Aerts for their invaluable teachings. The authors thank also the members of the Asteroseismology and Stellar Dynamics group of the Institute of Science and Technology Austria (ISTA) for very useful discussion: A. Cristea, L. Einramhof, K. M. Smith, S. Torres.","has_accepted_license":"1","date_published":"2025-09-01T00:00:00Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"isi":["001585834500002"],"arxiv":["2507.00308"]},"corr_author":"1","scopus_import":"1","citation":{"ama":"Barrault L, Bugnet LA, Mathis S, Mombarg JSG. Exploring the probing power of γ Dor’s inertial dip for core magnetism: The case of a toroidal field. <i>Astronomy &#38; Astrophysics</i>. 2025;701. doi:<a href=\"https://doi.org/10.1051/0004-6361/202555213\">10.1051/0004-6361/202555213</a>","ieee":"L. Barrault, L. A. Bugnet, S. Mathis, and J. S. G. Mombarg, “Exploring the probing power of γ Dor’s inertial dip for core magnetism: The case of a toroidal field,” <i>Astronomy &#38; Astrophysics</i>, vol. 701. EDP Sciences, 2025.","mla":"Barrault, Lucas, et al. “Exploring the Probing Power of γ Dor’s Inertial Dip for Core Magnetism: The Case of a Toroidal Field.” <i>Astronomy &#38; Astrophysics</i>, vol. 701, A253, EDP Sciences, 2025, doi:<a href=\"https://doi.org/10.1051/0004-6361/202555213\">10.1051/0004-6361/202555213</a>.","short":"L. Barrault, L.A. Bugnet, S. Mathis, J.S.G. Mombarg, Astronomy &#38; Astrophysics 701 (2025).","ista":"Barrault L, Bugnet LA, Mathis S, Mombarg JSG. 2025. Exploring the probing power of γ Dor’s inertial dip for core magnetism: The case of a toroidal field. Astronomy &#38; Astrophysics. 701, A253.","apa":"Barrault, L., Bugnet, L. A., Mathis, S., &#38; Mombarg, J. S. G. (2025). Exploring the probing power of γ Dor’s inertial dip for core magnetism: The case of a toroidal field. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202555213\">https://doi.org/10.1051/0004-6361/202555213</a>","chicago":"Barrault, Lucas, Lisa Annabelle Bugnet, S. Mathis, and J. S.G. Mombarg. “Exploring the Probing Power of γ Dor’s Inertial Dip for Core Magnetism: The Case of a Toroidal Field.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2025. <a href=\"https://doi.org/10.1051/0004-6361/202555213\">https://doi.org/10.1051/0004-6361/202555213</a>."},"date_created":"2025-10-12T22:01:26Z","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"_id":"20454","title":"Exploring the probing power of γ Dor's inertial dip for core magnetism: The case of a toroidal field","department":[{"_id":"LiBu"},{"_id":"GradSch"}],"oa":1,"article_processing_charge":"No","OA_place":"publisher","publication_status":"published","fulldoi":"https://doi.org/10.1051/0004-6361/202555213","oa_version":"Published Version","language":[{"iso":"eng"}],"year":"2025","project":[{"_id":"914d8549-16d5-11f0-9cad-bbe6324c93a9","name":"Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology","grant_number":"101165631"}],"type":"journal_article","publisher":"EDP Sciences","PlanS_conform":"1","file":[{"success":1,"file_size":2503149,"date_created":"2025-10-13T07:05:55Z","creator":"dernst","content_type":"application/pdf","checksum":"2c209b33119af4a251bab4a418a21075","file_id":"20459","access_level":"open_access","file_name":"2025_AstronomyAstrophysics_BarraultL.pdf","date_updated":"2025-10-13T07:05:55Z","relation":"main_file"}],"date_updated":"2026-02-19T09:32:04Z","intvolume":"       701","OA_type":"diamond","article_number":"A253","volume":701,"abstract":[{"text":"Context. γ Dor stars are ideal targets for studies of the innermost dynamical properties of stars, due to their rich asteroseismic spectrum of gravity modes. Integrating internal magnetism to the picture appears as the next milestone of detailed asteroseismic studies, for its prime importance on stellar evolution. The inertial dip in prograde dipole modes period-spacing pattern of γ Dors stands out as a unique window on the convective core structure and dynamics. Recent studies have highlighted the dependence of the dip structure on core density stratification, the contrast of the near-core Brunt-Väisälä frequency and rotation rate, as well as the core-to-near-core differential rotation. In addition, the effect of envelope magnetism has been derived on low-frequency magneto-gravito-inertial waves.\r\n\r\nAims. We revisited the inertial dip formation including core and envelope magnetism, and explored the probing power of this feature on dynamo-generated core fields.\r\n\r\nMethods. We considered as a first step a toroidal magnetic field with a bi-layer (core and envelope) Alfvén frequency. This configuration allowed us to revisit the coupling problem using our knowledge on both core magneto-inertial modes and envelope magneto-gravito-inertial modes. Using this configuration, we were able to stay in an analytical framework to exhibit the magnetic effects on the inertial dip shape and location. This configuration allowed a laboratory to be set up that moves us towards the comprehension of magnetic effects on the dip structure.\r\n\r\nResults. We show a shift of the inertial dip towards lower spin parameter values and a thinner dip with increasing core magnetic field’s strength, quite similar to the signature of differential rotation. The magnetic effects become sizeable when the ratio of the magnetic to the Coriolis effects is high enough. We explored the potential degeneracy of the magnetic effects with differential rotation. We studied the detectability of core magnetism, considering both observational constraints on the periods of the modes and potential gravito-inertial mode suppression.","lang":"eng"}],"arxiv":1},{"fulldoi":"https://doi.org/10.15479/AT-ISTA-20467","oa_version":"Published Version","OA_place":"publisher","publication_status":"published","article_processing_charge":"No","degree_awarded":"PhD","department":[{"_id":"GradSch"},{"_id":"SaSi"}],"_id":"20467","title":"The role of cyclooxygenase 1 on microglial response to inflammatory stressors","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-10-14T10:24:41Z","page":"99","date_updated":"2026-05-20T06:37:12Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"SSU"},{"_id":"PreCl"},{"_id":"LifeSc"}],"file":[{"date_updated":"2025-10-17T11:13:25Z","relation":"main_file","access_level":"closed","file_name":"2025_Miteva_Florianne_thesis.pdf","file_id":"20484","checksum":"03537697be8c688d3a05cf948288e48f","content_type":"application/pdf","embargo_to":"open_access","creator":"fschootu","date_created":"2025-10-17T11:09:11Z","file_size":13668588,"embargo":"2026-10-14"},{"file_size":28991918,"date_created":"2025-10-23T11:33:06Z","file_name":"2025_Miteva_florianne_thesis.docx","access_level":"closed","relation":"source_file","date_updated":"2025-10-23T11:33:06Z","creator":"fschootu","checksum":"df4930d7211cf9cfe1254b77204dc1d3","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"20525"}],"type":"dissertation","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"project":[{"grant_number":"P37131","_id":"7be82147-9f16-11ee-852c-f44682d73140","name":"Dissecting the morpho-functional relationship of microglia"}],"year":"2025","day":"14","supervisor":[{"last_name":"Siegert","first_name":"Sandra","orcid":"0000-0001-8635-0877","full_name":"Siegert, Sandra","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87"}],"alternative_title":["ISTA Thesis"],"doi":"10.15479/AT-ISTA-20467","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"19566"}]},"author":[{"first_name":"Florianne E","full_name":"Miteva, Florianne E","id":"3526230C-F248-11E8-B48F-1D18A9856A87","last_name":"Miteva"}],"status":"public","ddc":["570"],"month":"10","citation":{"chicago":"Miteva, Florianne E. “The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20467\">https://doi.org/10.15479/AT-ISTA-20467</a>.","short":"F.E. Miteva, The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors, Institute of Science and Technology Austria, 2025.","ista":"Miteva FE. 2025. The role of cyclooxygenase 1 on microglial response to inflammatory stressors. Institute of Science and Technology Austria.","apa":"Miteva, F. E. (2025). <i>The role of cyclooxygenase 1 on microglial response to inflammatory stressors</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20467\">https://doi.org/10.15479/AT-ISTA-20467</a>","mla":"Miteva, Florianne E. <i>The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20467\">10.15479/AT-ISTA-20467</a>.","ama":"Miteva FE. The role of cyclooxygenase 1 on microglial response to inflammatory stressors. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20467\">10.15479/AT-ISTA-20467</a>","ieee":"F. E. Miteva, “The role of cyclooxygenase 1 on microglial response to inflammatory stressors,” Institute of Science and Technology Austria, 2025."},"corr_author":"1","date_published":"2025-10-14T00:00:00Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","acknowledgement":"The work presented in this Thesis was carried out at the Institute of Science and Technology\r\nAustria (ISTA), and was supported by the Austrian Science Fund (FWF) [10.55776/P37131].\r\nI would like to thank the Scientific Service Units (SSU) of ISTA for the provided resources,\r\nspecifically the Imaging and Optics Facility (IOF), the Lab Support Facility (LSF), and the\r\nPre-Clinical Facility (PCF) team, specifically Sonja Haslinger, Claudia Gold, and Michael\r\nSchunn, for mouse colony management and support. ","file_date_updated":"2025-10-23T11:33:06Z"},{"corr_author":"1","file_date_updated":"2025-11-06T11:08:06Z","has_accepted_license":"1","acknowledgement":"I would also like to acknowledge the funding that I received from the European Union’s\r\nHorizon 2020 research and Innovation programme under the Marie Sklodowska-Curie\r\nGrant Agreement No. 665385. This work would not have been possible without the contribution and support of people\r\nbehind the scientific service units at ISTA: the Life Science Facility (LSF), Imaging and\r\nOptics Facility (IOF), the Bioinformatics Unit, Protein Services Unit and\r\nElectrophysiology Unit. I would also like to recognize the work of people at the Vienna\r\nBiocenter (VBC) Mass Spectrometry Facility, particularly Markus Hartl and WeiQiang\r\nChen. ","date_published":"2025-10-23T00:00:00Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"ieee":"M. Misova, “Dissecting gap junction biology using the C. elegans nervous system,” Institute of Science and Technology Austria, 2025.","ama":"Misova M. Dissecting gap junction biology using the C. elegans nervous system. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20485\">10.15479/AT-ISTA-20485</a>","apa":"Misova, M. (2025). <i>Dissecting gap junction biology using the C. elegans nervous system</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20485\">https://doi.org/10.15479/AT-ISTA-20485</a>","ista":"Misova M. 2025. Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria.","short":"M. Misova, Dissecting Gap Junction Biology Using the C. Elegans Nervous System, Institute of Science and Technology Austria, 2025.","mla":"Misova, Michaela. <i>Dissecting Gap Junction Biology Using the C. Elegans Nervous System</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20485\">10.15479/AT-ISTA-20485</a>.","chicago":"Misova, Michaela. “Dissecting Gap Junction Biology Using the C. Elegans Nervous System.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20485\">https://doi.org/10.15479/AT-ISTA-20485</a>."},"ec_funded":1,"status":"public","ddc":["570"],"month":"10","author":[{"orcid":"0000-0003-2427-6856","full_name":"Misova, Michaela","id":"495A3C32-F248-11E8-B48F-1D18A9856A87","first_name":"Michaela","last_name":"Misova"}],"supervisor":[{"last_name":"de Bono","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443","full_name":"de Bono, Mario","first_name":"Mario"}],"day":"23","doi":"10.15479/AT-ISTA-20485","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","alternative_title":["ISTA Thesis"],"year":"2025","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"}],"language":[{"iso":"eng"}],"publisher":"Institute of Science and Technology Austria","type":"dissertation","page":"155","file":[{"file_id":"20518","checksum":"e042ea314e7e13fce76c6c95e126779a","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"mmisova","relation":"source_file","date_updated":"2025-11-06T11:08:06Z","file_name":"2025-Misova-Michaela-Thesis.docx","access_level":"closed","date_created":"2025-10-23T08:22:35Z","file_size":75070995},{"relation":"main_file","date_updated":"2025-10-23T08:21:21Z","file_name":"2025-Misova-Michaela-Thesis.pdf","access_level":"closed","embargo_to":"open_access","creator":"mmisova","file_id":"20519","checksum":"fcd8973d6a025256eb0eb1a82c02172c","content_type":"application/pdf","file_size":10974630,"date_created":"2025-10-23T08:21:21Z","embargo":"2026-10-23"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"date_updated":"2026-04-07T11:54:00Z","title":"Dissecting gap junction biology using the C. elegans nervous system","_id":"20485","department":[{"_id":"GradSch"},{"_id":"MaDe"}],"degree_awarded":"PhD","date_created":"2025-10-17T16:15:09Z","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-068-8"]},"publication_status":"published","OA_place":"publisher","oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-20485","article_processing_charge":"No"},{"citation":{"chicago":"Riabov, Volodymyr. “Universality in Random Matrices with Spatial Structure.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20575\">https://doi.org/10.15479/AT-ISTA-20575</a>.","apa":"Riabov, V. (2025). <i>Universality in random matrices with spatial structure</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20575\">https://doi.org/10.15479/AT-ISTA-20575</a>","short":"V. Riabov, Universality in Random Matrices with Spatial Structure, Institute of Science and Technology Austria, 2025.","ista":"Riabov V. 2025. Universality in random matrices with spatial structure. Institute of Science and Technology Austria.","mla":"Riabov, Volodymyr. <i>Universality in Random Matrices with Spatial Structure</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20575\">10.15479/AT-ISTA-20575</a>.","ieee":"V. Riabov, “Universality in random matrices with spatial structure,” Institute of Science and Technology Austria, 2025.","ama":"Riabov V. Universality in random matrices with spatial structure. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20575\">10.15479/AT-ISTA-20575</a>"},"ec_funded":1,"corr_author":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-11-03T00:00:00Z","file_date_updated":"2025-10-29T18:54:53Z","has_accepted_license":"1","acknowledgement":"The work comprising this thesis was supported by the ERC Advanced Grant \"RMTBeyond\"\r\nNo.101020331 awarded to my advisor.","day":"3","supervisor":[{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"}],"alternative_title":["ISTA Thesis"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/AT-ISTA-20575","related_material":{"record":[{"id":"20322","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"18764"},{"id":"13317","relation":"part_of_dissertation","status":"public"},{"id":"19368","relation":"part_of_dissertation","status":"deleted"},{"status":"public","relation":"part_of_dissertation","id":"18554"},{"id":"20576","status":"public","relation":"part_of_dissertation"},{"id":"17174","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"19547"},{"id":"19598","relation":"part_of_dissertation","status":"public"}]},"status":"public","month":"11","ddc":["515","519"],"author":[{"full_name":"Riabov, Volodymyr","id":"1949f904-edfb-11eb-afb5-e2dfddabb93b","first_name":"Volodymyr","last_name":"Riabov"}],"abstract":[{"text":"This thesis deals with eigenvalue and eigenvector universality results for random matrix ensembles equipped with non-trivial spatial structure. We consider both mean-field models with a general variance profile (Wigner-type matrices) and correlation structure (correlated matrices) among the entries, as well as non-mean-field random band matrices with bandwidth W >> N^(1/2).\r\n\r\nTo extract the universal properties of random matrix spectra and eigenvectors, we obtain concentration estimates for their resolvent, the local laws, which generalize the celebrated Wigner semicircle law for a broad class of random matrices to much finer spectral scales. The local laws hold for both a single resolvent as well as for products of multiple resolvents, known as resolvent chains, and express the remarkable approximately-deterministic behavior of these objects down to the microscopic scale.\r\n\r\nOur primary tool for establishing the local laws is the dynamical Zigzag strategy, which we develop in the setting of spatially-inhomogeneous random matrices. Our proof method systematically addresses the challenges arising from non-trivial spatial structures and is robust to all types of singularities in the spectrum, as we demonstrate in the correlated setting. Furthermore, we incorporate the analysis of the deterministic resolvent chain approximations into the dynamical framework of the Zigzag strategy, synthesizing a unified toolkit for establishing multi-resolvent local laws.\r\n\r\nUsing these methods, we prove complete eigenvector delocalization, the Eigenstate Thermalization Hypothesis, and Wigner-Dyson universality in the bulk for random band matrices down to the optimal bandwidth W >> N^(1/2). For mean-field ensembles, we establish universality of local eigenvalue statistics at the cups for random matrices with correlated entries, and the Eigenstate Thermalization Hypothesis for Wigner-type matrices in the bulk of the spectrum.\r\n\r\nFinally, this thesis also contains other applications of the multi-resolvent local laws to spatially-inhomogeneous random matrices, obtained prior to the development of the Zigzag strategy. In particular, we provide a complete analysis of mesoscopic linear-eigenvalue statistics of Wigner-type matrices in all spectral regimes, including the novel cusps, and rigorously establish the prethermalization phenomenon for deformed Wigner matrices.\r\n\r\nThe main body of this thesis consists of seven research papers (listed on page xi), each presented in a separate chapter with its own introduction and all relevant context, suitable to be read independently. We ask the reader’s indulgence for the repetitions in the historical overviews and other minor redundancies that remain among the chapters as a result. The overall Introduction, preceding the chapters, provides a condensed, informal summary of the main ideas and concepts at the core of these works.\r\n","lang":"eng"}],"page":"436","date_updated":"2026-04-07T12:32:20Z","file":[{"access_level":"open_access","file_name":"riabov_thesis-pdfa.pdf","relation":"main_file","date_updated":"2025-10-29T18:53:59Z","content_type":"application/pdf","checksum":"6a0487b2b66bb35d44b394756d44b8b4","file_id":"20577","creator":"vriabov","date_created":"2025-10-29T18:53:59Z","file_size":7536583,"success":1},{"date_created":"2025-10-29T18:54:53Z","file_size":17841612,"date_updated":"2025-10-29T18:54:53Z","relation":"source_file","access_level":"closed","file_name":"manuscript.zip","file_id":"20578","checksum":"224efda6bf9864d296a1e5e0124c1e8f","content_type":"application/x-zip-compressed","creator":"vriabov"}],"publisher":"Institute of Science and Technology Austria","type":"dissertation","year":"2025","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","grant_number":"101020331"}],"language":[{"iso":"eng"}],"oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-20575","publication_status":"published","OA_place":"publisher","article_processing_charge":"No","oa":1,"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"degree_awarded":"PhD","title":"Universality in random matrices with spatial structure","_id":"20575","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-064-0"]},"date_created":"2025-10-29T19:12:24Z"},{"abstract":[{"lang":"eng","text":"We prove that a very general class of $N\\times N$ Hermitian random band matrices is in the delocalized phase when the band width $W$ exceeds the critical threshold, $W\\gg \\sqrt{N}$. In this regime, we show that, in the bulk spectrum, the eigenfunctions are fully delocalized, the eigenvalues follow the universal Wigner-Dyson statistics, and quantum unique ergodicity holds for general diagonal observables with an optimal convergence rate. Our results are valid for general variance profiles, arbitrary single entry distributions, in both real-symmetric and complex-Hermitian symmetry classes. In particular, our work substantially generalizes the recent breakthrough result of Yau and Yin [arXiv:2501.01718], obtained for a specific complex Hermitian Gaussian block band matrix. The main technical input is the optimal multi-resolvent local laws -- both in the averaged and fully isotropic form. We also generalize the $\\sqrtη$-rule from [arXiv:2012.13215] to exploit the additional effect of traceless observables. Our analysis is based on the zigzag strategy, complemented with a new global-scale estimate derived using the static version of the master inequalities, while the zig-step and the a priori estimates on the deterministic approximations are proven dynamically."}],"citation":{"mla":"Erdös, László, and Volodymyr Riabov. “The Zigzag Strategy for Random Band Matrices.” <i>ArXiv</i>, doi:<a href=\"https://doi.org/10.48550/ARXIV.2506.06441\">10.48550/ARXIV.2506.06441</a>.","apa":"Erdös, L., &#38; Riabov, V. (n.d.). The zigzag strategy for random band matrices. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/ARXIV.2506.06441\">https://doi.org/10.48550/ARXIV.2506.06441</a>","short":"L. Erdös, V. Riabov, ArXiv (n.d.).","ista":"Erdös L, Riabov V. The zigzag strategy for random band matrices. arXiv, <a href=\"https://doi.org/10.48550/ARXIV.2506.06441\">10.48550/ARXIV.2506.06441</a>.","chicago":"Erdös, László, and Volodymyr Riabov. “The Zigzag Strategy for Random Band Matrices.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/ARXIV.2506.06441\">https://doi.org/10.48550/ARXIV.2506.06441</a>.","ieee":"L. Erdös and V. Riabov, “The zigzag strategy for random band matrices,” <i>arXiv</i>. .","ama":"Erdös L, Riabov V. The zigzag strategy for random band matrices. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/ARXIV.2506.06441\">10.48550/ARXIV.2506.06441</a>"},"date_updated":"2026-04-07T12:32:19Z","ec_funded":1,"corr_author":"1","date_published":"2025-06-06T00:00:00Z","type":"preprint","language":[{"iso":"eng"}],"acknowledgement":" Supported by the ERC\r\nAdvanced Grant ”RMTBeyond” No. 101020331.","project":[{"grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"year":"2025","fulldoi":"https://doi.org/10.48550/ARXIV.2506.06441","oa_version":"Preprint","day":"06","OA_place":"repository","publication_status":"draft","article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","doi":"10.48550/ARXIV.2506.06441","oa":1,"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publication":"arXiv","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"20575"}]},"_id":"20576","title":"The zigzag strategy for random band matrices","author":[{"last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Riabov","first_name":"Volodymyr","full_name":"Riabov, Volodymyr","id":"1949f904-edfb-11eb-afb5-e2dfddabb93b"}],"month":"06","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2506.06441"}],"date_created":"2025-10-29T19:09:03Z"},{"citation":{"ieee":"A. Chern and S. Ishida, “Implicit representations of codimension-2 submanifolds and their prequantum structure,” <i>arXiv</i>. .","ama":"Chern A, Ishida S. Implicit representations of codimension-2 submanifolds and their prequantum structure. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/ARXIV.2507.11727\">10.48550/ARXIV.2507.11727</a>","chicago":"Chern, Albert, and Sadashige Ishida. “Implicit Representations of Codimension-2 Submanifolds and Their Prequantum Structure.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/ARXIV.2507.11727\">https://doi.org/10.48550/ARXIV.2507.11727</a>.","mla":"Chern, Albert, and Sadashige Ishida. “Implicit Representations of Codimension-2 Submanifolds and Their Prequantum Structure.” <i>ArXiv</i>, doi:<a href=\"https://doi.org/10.48550/ARXIV.2507.11727\">10.48550/ARXIV.2507.11727</a>.","apa":"Chern, A., &#38; Ishida, S. (n.d.). Implicit representations of codimension-2 submanifolds and their prequantum structure. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/ARXIV.2507.11727\">https://doi.org/10.48550/ARXIV.2507.11727</a>","short":"A. Chern, S. Ishida, ArXiv (n.d.).","ista":"Chern A, Ishida S. Implicit representations of codimension-2 submanifolds and their prequantum structure. arXiv, <a href=\"https://doi.org/10.48550/ARXIV.2507.11727\">10.48550/ARXIV.2507.11727</a>."},"arxiv":1,"abstract":[{"text":"This paper explores the geometry of the space of codimension-2 submanifolds. We implicitly represent these submanifolds by a class of complex-valued functions. This reveals a prequantum bundle structure over the space of submanifolds, equipped with the well-known Marsden-Weinstein symplectic structure. This bundle allows a new physical interpretation of the Marsden-Weinstein structure as the curvature of a connection form, which measures the average of volumes swept by the deformation of the S^1-family of hypersurfaces, defined as the phases of a complex function implicitly representing a submanifold.","lang":"eng"}],"date_updated":"2026-04-07T12:02:23Z","external_id":{"arxiv":["2507.11727"]},"corr_author":"1","language":[{"iso":"eng"}],"year":"2025","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-07-15T00:00:00Z","type":"preprint","OA_place":"repository","publication_status":"draft","fulldoi":"https://doi.org/10.48550/ARXIV.2507.11727","oa_version":"Preprint","day":"15","oa":1,"doi":"10.48550/ARXIV.2507.11727","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","_id":"20580","related_material":{"record":[{"id":"20551","relation":"dissertation_contains","status":"public"}]},"title":"Implicit representations of codimension-2 submanifolds and their prequantum structure","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"publication":"arXiv","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2507.11727"}],"date_created":"2025-10-30T18:36:56Z","author":[{"first_name":"Albert","full_name":"Chern, Albert","last_name":"Chern"},{"full_name":"Ishida, Sadashige","orcid":"0000-0002-3121-3100","id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","first_name":"Sadashige","last_name":"Ishida"}],"status":"public","month":"07"},{"language":[{"iso":"eng"}],"year":"2025","project":[{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088","grant_number":"101045083"}],"type":"journal_article","publisher":"Association for Computing Machinery","article_number":"220","volume":44,"abstract":[{"text":"The realistic simulation of sand, soil, powders, rubble piles, and large collections of rigid bodies is a common and important problem in the fields of computer graphics, computational physics, and engineering. Direct simulation of these individual bodies quickly becomes expensive, so we often approximate the entire group as a continuum material that can be more easily computed using tools for solving partial differential equations, like the material point method (MPM). In this paper, we present a method for automatically extracting continuum material properties from a collection of rigid\r\nbodies. We use numerical homogenization with periodic boundary conditions to simulate an effectively infinite number of rigid bodies in contact. We then record the effective stress-strain relationships from these simulations and convert them into elastic properties and yield criteria for the continuum simulations. Our experiments validate existing theoretical models like the Mohr-Coulomb yield surface by extracting material behaviors from a collection of spheres in contact. We further generalize these existing models to more exotic materials derived from diverse and non-convex shapes. We\r\nobserve complicated jamming behaviors from non-convex grains, and we introduce a new material model for materials with extremely high levels of internal friction and cohesion. We simulate these new continuum models using MPM with an improved return mapping technique. The end result is a complete system for turning an input rigid body simulation into an efficient continuum simulation with the same effective mechanical properties.","lang":"eng"}],"file":[{"file_size":61708650,"date_created":"2025-11-10T14:10:12Z","success":1,"relation":"main_file","date_updated":"2025-11-10T14:10:12Z","file_name":"main_paper.pdf","access_level":"open_access","creator":"yichen","file_id":"20629","checksum":"4d30ff82314e76fe411c8f8195bb6040","content_type":"application/pdf"},{"relation":"supplementary_material","date_updated":"2025-11-10T14:10:27Z","access_level":"open_access","file_name":"paper_supplemental.pdf","file_id":"20630","checksum":"f1b6df39487866044ca7ca899d044be7","content_type":"application/pdf","creator":"yichen","date_created":"2025-11-10T14:10:27Z","file_size":6862285},{"date_updated":"2025-11-10T14:10:44Z","relation":"supplementary_material","access_level":"open_access","file_name":"main_video.mp4","creator":"yichen","file_id":"20631","checksum":"04ec2a4866774673479cafe5b93d26bd","content_type":"video/mp4","file_size":164079303,"date_created":"2025-11-10T14:10:44Z"},{"date_created":"2025-11-10T14:10:53Z","file_size":72234678,"access_level":"open_access","file_name":"extra_video.mp4","date_updated":"2025-11-10T14:10:53Z","relation":"supplementary_material","checksum":"7495e8cbcf94eb49276b4730c5886914","content_type":"video/mp4","file_id":"20632","creator":"yichen"}],"conference":{"start_date":"2025-12-15","location":"Hong Kong, China","end_date":"2025-12-18","name":"SIGGRAPH Asia: Conference and Exhibition on Computer Graphics and Interactive Techniques in Asia"},"OA_type":"hybrid","date_updated":"2025-12-09T14:53:32Z","intvolume":"        44","_id":"20628","title":"Numerical homogenization of sand from grain-level simulations","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"date_created":"2025-11-10T14:12:06Z","publication_identifier":{"issn":["0730-0301"],"eissn":["1557-7368"]},"OA_place":"publisher","publication_status":"published","fulldoi":"https://doi.org/10.1145/3763344","oa_version":"Published Version","oa":1,"article_processing_charge":"Yes (via OA deal)","corr_author":"1","file_date_updated":"2025-11-10T14:10:53Z","acknowledgement":"We thank the anonymous reviewers for their helpful comments, the members of the Visual Computing Group at ISTA for their feedback and Gauthier Rousseau for the insightful discussions. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by Scientific Computing and was funded in part by the European Union (ERC-2021-COG 101045083 CoDiNA). ","has_accepted_license":"1","tmp":{"short":"CC BY-ND (4.0)","image":"/image/cc_by_nd.png","name":"Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nd/4.0/legalcode"},"date_published":"2025-12-04T00:00:00Z","citation":{"ieee":"Y.-L. Chen, M. Ly, and C. Wojtan, “Numerical homogenization of sand from grain-level simulations,” <i>ACM Transactions on Graphics</i>, vol. 44, no. 6. Association for Computing Machinery, 2025.","ama":"Chen Y-L, Ly M, Wojtan C. Numerical homogenization of sand from grain-level simulations. <i>ACM Transactions on Graphics</i>. 2025;44(6). doi:<a href=\"https://doi.org/10.1145/3763344\">10.1145/3763344</a>","short":"Y.-L. Chen, M. Ly, C. Wojtan, ACM Transactions on Graphics 44 (2025).","apa":"Chen, Y.-L., Ly, M., &#38; Wojtan, C. (2025). Numerical homogenization of sand from grain-level simulations. <i>ACM Transactions on Graphics</i>. Hong Kong, China: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3763344\">https://doi.org/10.1145/3763344</a>","ista":"Chen Y-L, Ly M, Wojtan C. 2025. Numerical homogenization of sand from grain-level simulations. ACM Transactions on Graphics. 44(6), 220.","mla":"Chen, Yi-Lu, et al. “Numerical Homogenization of Sand from Grain-Level Simulations.” <i>ACM Transactions on Graphics</i>, vol. 44, no. 6, 220, Association for Computing Machinery, 2025, doi:<a href=\"https://doi.org/10.1145/3763344\">10.1145/3763344</a>.","chicago":"Chen, Yi-Lu, Mickaël Ly, and Chris Wojtan. “Numerical Homogenization of Sand from Grain-Level Simulations.” <i>ACM Transactions on Graphics</i>. Association for Computing Machinery, 2025. <a href=\"https://doi.org/10.1145/3763344\">https://doi.org/10.1145/3763344</a>."},"scopus_import":"1","quality_controlled":"1","publication":"ACM Transactions on Graphics","issue":"6","author":[{"id":"0b467602-dbcd-11ea-9d1d-ed480aa46b70","orcid":"0009-0005-0723-0655","full_name":"Chen, Yi-Lu","first_name":"Yi-Lu","last_name":"Chen"},{"full_name":"Ly, Mickaël","id":"6340d7f0-b48d-11eb-b10d-b7487e71d9f1","first_name":"Mickaël","last_name":"Ly"},{"last_name":"Wojtan","first_name":"Christopher J","orcid":"0000-0001-6646-5546","full_name":"Wojtan, Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87"}],"ddc":["531","006","621"],"status":"public","month":"12","license":"https://creativecommons.org/licenses/by-nd/4.0/","article_type":"original","day":"04","doi":"10.1145/3763344","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"article_processing_charge":"Yes","DOAJ_listed":"1","oa":1,"oa_version":"Published Version","fulldoi":"https://doi.org/10.5194/mr-6-243-2025","publication_status":"published","OA_place":"publisher","publication_identifier":{"eissn":["2699-0016"]},"date_created":"2025-11-23T23:01:39Z","department":[{"_id":"JoFi"},{"_id":"GaTk"},{"_id":"JoCs"},{"_id":"EvBe"},{"_id":"TaHa"},{"_id":"GradSch"},{"_id":"GeKa"},{"_id":"PaSc"}],"title":"Quantifying the carbon footprint of conference travel: The case of NMR meetings","_id":"20664","OA_type":"gold","intvolume":"         6","date_updated":"2026-06-10T08:45:11Z","file":[{"success":1,"file_size":3081399,"date_created":"2025-11-24T08:25:19Z","creator":"dernst","file_id":"20672","checksum":"c63dd47b0e77f9451821436bb77d27c9","content_type":"application/pdf","relation":"main_file","date_updated":"2025-11-24T08:25:19Z","access_level":"open_access","file_name":"2025_MagneticResonance_Kapoor.pdf"}],"abstract":[{"text":"Conference travel contributes to the climate footprint of academic research. Here, we provide a quantitative estimate of the carbon emissions associated with conference attendance by analyzing travel data from participants of 10 international conferences in the field of magnetic resonance, namely EUROMAR, ENC and ICMRBS. We find that attending a EUROMAR conference produces, on average, more than 1 t CO2 eq.. For the analyzed conferences outside Europe, the corresponding value is about 2–3 times higher, on average, with intercontinental trips amounting to up to 5 t. We compare these conference-related emissions to other activities associated with research and show that conference travel is a substantial portion of the total climate footprint of a researcher in magnetic resonance. We explore several strategies to reduce these emissions, including the impact of selecting conference venues more strategically and the possibility of decentralized conferences. Through a detailed comparison of train versus air travel – accounting for both direct and infrastructure-related emissions – we demonstrate that train travel offers considerable carbon savings. These data may provide a basis for strategic choices of future conferences in the field and for individuals deciding on their conference attendance.","lang":"eng"}],"volume":6,"page":"243-256","publisher":"Copernicus Publications","PlanS_conform":"1","type":"journal_article","year":"2025","project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"language":[{"iso":"eng"}],"doi":"10.5194/mr-6-243-2025","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"10","article_type":"original","status":"public","month":"11","ddc":["000"],"APC_amount":"1260 EUR","author":[{"first_name":"Lucky","full_name":"Kapoor, Lucky","orcid":"0000-0001-8319-2148","id":"84b9700b-15b2-11ec-abd3-831089e67615","last_name":"Kapoor"},{"first_name":"Natalia","full_name":"Ruzickova, Natalia","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","last_name":"Ruzickova"},{"last_name":"Zivadinovic","first_name":"Predrag","full_name":"Zivadinovic, Predrag","id":"68AA0E5A-AFDA-11E9-9994-141DE6697425"},{"last_name":"Leitner","first_name":"Valentin","id":"4c665ce3-0016-11ec-bea0-e44de7a4fa3d","full_name":"Leitner, Valentin"},{"last_name":"Sisak","first_name":"Maria A","id":"44A03D04-AEA4-11E9-B225-EA2DE6697425","full_name":"Sisak, Maria A"},{"id":"2a69ab4b-896a-11ed-bdf8-cb8641cf2b21","full_name":"Mweka, Cecelia N","first_name":"Cecelia N","last_name":"Mweka"},{"last_name":"Dobbelaere","first_name":"Jeroen A","id":"c15a5412-de82-11ed-b809-8dc1aa996e40","full_name":"Dobbelaere, Jeroen A"},{"id":"38DB5788-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8342-202X","full_name":"Katsaros, Georgios","first_name":"Georgios","last_name":"Katsaros"},{"last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","first_name":"Paul"}],"issue":"2","publication":"Magnetic Resonance","quality_controlled":"1","related_material":{"link":[{"url":"https://ista.ac.at/en/news/carbon-footprint-of-conference-travel/","relation":"research_data","description":"News on ISTA website"}],"record":[{"id":"20242","relation":"research_data","status":"public"}]},"scopus_import":"1","citation":{"mla":"Kapoor, Lucky, et al. “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” <i>Magnetic Resonance</i>, vol. 6, no. 2, Copernicus Publications, 2025, pp. 243–56, doi:<a href=\"https://doi.org/10.5194/mr-6-243-2025\">10.5194/mr-6-243-2025</a>.","ista":"Kapoor L, Ruzickova N, Zivadinovic P, Leitner V, Sisak MA, Mweka CN, Dobbelaere JA, Katsaros G, Schanda P. 2025. Quantifying the carbon footprint of conference travel: The case of NMR meetings. Magnetic Resonance. 6(2), 243–256.","apa":"Kapoor, L., Ruzickova, N., Zivadinovic, P., Leitner, V., Sisak, M. A., Mweka, C. N., … Schanda, P. (2025). Quantifying the carbon footprint of conference travel: The case of NMR meetings. <i>Magnetic Resonance</i>. Copernicus Publications. <a href=\"https://doi.org/10.5194/mr-6-243-2025\">https://doi.org/10.5194/mr-6-243-2025</a>","short":"L. Kapoor, N. Ruzickova, P. Zivadinovic, V. Leitner, M.A. Sisak, C.N. Mweka, J.A. Dobbelaere, G. Katsaros, P. Schanda, Magnetic Resonance 6 (2025) 243–256.","chicago":"Kapoor, Lucky, Natalia Ruzickova, Predrag Zivadinovic, Valentin Leitner, Maria A Sisak, Cecelia N Mweka, Jeroen A Dobbelaere, Georgios Katsaros, and Paul Schanda. “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” <i>Magnetic Resonance</i>. Copernicus Publications, 2025. <a href=\"https://doi.org/10.5194/mr-6-243-2025\">https://doi.org/10.5194/mr-6-243-2025</a>.","ieee":"L. Kapoor <i>et al.</i>, “Quantifying the carbon footprint of conference travel: The case of NMR meetings,” <i>Magnetic Resonance</i>, vol. 6, no. 2. Copernicus Publications, pp. 243–256, 2025.","ama":"Kapoor L, Ruzickova N, Zivadinovic P, et al. Quantifying the carbon footprint of conference travel: The case of NMR meetings. <i>Magnetic Resonance</i>. 2025;6(2):243-256. doi:<a href=\"https://doi.org/10.5194/mr-6-243-2025\">10.5194/mr-6-243-2025</a>"},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-11-10T00:00:00Z","has_accepted_license":"1","acknowledgement":"First and foremost, we are grateful to the conference organizers who have provided data, either in the form of tables or by pointing us to abstract books. We thank the reviewers and the handling editor (Gottfried Otting) for the careful reading and suggestions. This project emerged from an interactive course about energy and climate, held at IST Austria by Jeroen Dobbelaere, Georgios Katsaros and Paul Schanda. We are grateful to ISTA's Graduate School for enabling this interdisciplinary course and to all participating students. We thank the following persons for discussions and/or comments about the manuscript: Helene Van Melckebeke, Mei Hong, Jeff Hoch, Gottfried Otting and Matthias Ernst. For the preparation of the manuscript, AI tools have been used, namely for finding relevant literature (ChatGPT) and for correcting the text (Writefull, within Overleaf LaTeX).","file_date_updated":"2025-11-24T08:25:19Z","corr_author":"1"},{"page":"133","date_updated":"2026-04-14T08:16:58Z","file":[{"file_name":"2025_CasadoPolanco_Raquel_Thesis.docx","access_level":"closed","relation":"source_file","date_updated":"2025-12-11T11:18:37Z","creator":"rcasadop","checksum":"71e0fdf4619b0d70d03657ad7348137d","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"20793","file_size":78207207,"date_created":"2025-12-11T09:28:09Z"},{"file_id":"20794","content_type":"application/pdf","checksum":"58cf2f25c33567723bc754a019c3e396","embargo_to":"open_access","creator":"rcasadop","relation":"main_file","date_updated":"2025-12-11T09:28:04Z","file_name":"2025_CasadoPolanco_Raquel_Thesis.pdf","access_level":"closed","embargo":"2026-12-01","date_created":"2025-12-11T09:28:04Z","file_size":6261874}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"publisher":"Institute of Science and Technology Austria","type":"dissertation","year":"2025","project":[{"name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","grant_number":"F7805"}],"language":[{"iso":"eng"}],"oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-20737","publication_status":"published","OA_place":"publisher","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"SiHi"}],"degree_awarded":"PhD","title":"Role of NOTCH signaling in radial glial progenitor lineage progression","_id":"20737","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-072-5"]},"date_created":"2025-12-09T09:04:18Z","citation":{"apa":"Casado Polanco, R. (2025). <i>Role of NOTCH signaling in radial glial progenitor lineage progression</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20737\">https://doi.org/10.15479/AT-ISTA-20737</a>","ista":"Casado Polanco R. 2025. Role of NOTCH signaling in radial glial progenitor lineage progression. Institute of Science and Technology Austria.","short":"R. Casado Polanco, Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression, Institute of Science and Technology Austria, 2025.","mla":"Casado Polanco, Raquel. <i>Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20737\">10.15479/AT-ISTA-20737</a>.","chicago":"Casado Polanco, Raquel. “Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20737\">https://doi.org/10.15479/AT-ISTA-20737</a>.","ama":"Casado Polanco R. Role of NOTCH signaling in radial glial progenitor lineage progression. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20737\">10.15479/AT-ISTA-20737</a>","ieee":"R. Casado Polanco, “Role of NOTCH signaling in radial glial progenitor lineage progression,” Institute of Science and Technology Austria, 2025."},"corr_author":"1","date_published":"2025-12-09T00:00:00Z","file_date_updated":"2025-12-11T11:18:37Z","acknowledgement":"I also want to thank ISTA and the Austrian Science Fund FWF SFB F78 (F7805) for financially\r\nsupporting my research.","has_accepted_license":"1","day":"09","supervisor":[{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"keyword":["NOTCH","radial glial progenitor","lineage progression","cortical development"],"alternative_title":["ISTA Thesis"],"doi":"10.15479/AT-ISTA-20737","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","status":"public","month":"12","ddc":["570"],"author":[{"id":"15240fc1-dbcd-11ea-9d1d-ac5a786425fd","orcid":"0000-0001-8293-4568","full_name":"Casado Polanco, Raquel","first_name":"Raquel","last_name":"Casado Polanco"}]},{"language":[{"iso":"eng"}],"year":"2025","type":"dissertation","publisher":"Institute of Science and Technology Austria","abstract":[{"text":"Life on Earth emerged when biomacromolecules were membrane-enclosed in a confined space where many essential chemical reactions were more likely to happen and thereby accelerate evolution. These kinds of membranes separated internal reactions from the outside chaos while staying flexible so that those primordial cells can move, adopt their shape and, most importantly, propagate. Such membrane plasticity still remains a defining feature of all modern cell types. This remarkable ability to change their shape is most prominently observed during their propagation (i.e., cell division). Throughout division, a cell undergoes drastic change in its shape, usually at the middle of the cell, pulling the two opposite membrane sides inward, closer to each other, and, finally, culminating in pinching off to separate the cell into two daughter cells. To achieve this, a cell needs to employ a protein machinery, usually termed divisome, that can coordinate all necessary intracellular processes with membrane remodelling and synthesis of other extracellular structures that decorate a cell. The focus of this dissertation is a membrane-remodelling FtsZ system that is present across all domains of life. FtsZ forms filaments that further self-organize into ring-like structures at the cell septum and together with other division proteins perform cell envelope synthesis and constriction. However, there are still knowledge gaps in our mechanistic understanding of division in both archaea and bacteria. My work presented in this dissertation centres around a simple yet not well understood question: How is the divisome positioned correctly at the mid-cell? To achieve the proper positioning, the divisome needs to (i) be recruited to the mid-cell and (ii) localized orthogonally to the long cell axis. I tackle these processes in two different systems by applying an in vitro biochemical bottom-up reconstitution approach. I use purified components of Haloferax volcanii and Escherichia coli divisome to explore how divisome is recruited to the mid-cell in archaea and how the Z-ring positions orthogonally to the long cell axis in bacteria, respectively. \r\n\r\nFirstly, I collaborate with archaeal cell and structural biologists to explore the assembly of early division proteins in two FtsZ-containing archaeon H. volcanii, a standard model system for understudied archaeal organisms. I particularly address the hierarchy of interactions that allow a tripartite complex formation (SepF-CdpB1-CdpB2) and how the hierarchy of interactions ultimately leads to the recruitment of FtsZ filaments to the septum. This part of work has been published in (Nußbaum et al., 2024). In collaboration with evolutionary biologists, I shed light on ancient features that archaeal divisome has retained to this day and also speculate on a property that it might have lost during the course of evolution. \r\n\r\nNext, I switch my attention to E. coli divisome. Particularly, I address the FtsZ’s intrinsic biophysical property that drives the Z-ring diameter, and thereby the perpendicular orientation of the Z-ring to the long cell axis based on suggested membrane curvature sensing mechanism (Vanhille-Campos et al., 2024). This property allows formation of different Z-ring diameters that match the variety of cell diameters present in prokaryotes. The results showcase that the distribution of charged amino acids in the intrinsically disordered linker at the C-terminus (CTL) of FtsZ is the major determining factor of Z-ring diameter with inter-CTL interactions as an underlying mechanism. \r\n\r\nFinally, I thoroughly explain the methodology I used to address the abovementioned projects, and I finish with a discussion on how early archaeal divisome assembly and curvature sensing mechanism in bacteria, at first sight unrelated topics, are interconnected and important groundwork for both fundamental and translational research. ","lang":"eng"}],"acknowledged_ssus":[{"_id":"Bio"}],"file":[{"file_name":"2025_marko_kojic_thesis.docx","access_level":"closed","relation":"source_file","date_updated":"2025-12-10T13:09:58Z","checksum":"a3643d07e93134b2490a566b02a4517d","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"20774","creator":"mkojic","date_created":"2025-12-10T13:09:58Z","file_size":142876975},{"success":1,"date_created":"2025-12-10T13:09:38Z","file_size":8597045,"checksum":"0a096f0af6ccc3a8329d5bb8797ad533","content_type":"application/pdf","file_id":"20775","creator":"mkojic","access_level":"open_access","file_name":"2025_marko_kojic_thesis.pdf","relation":"main_file","date_updated":"2025-12-10T13:09:38Z"}],"date_updated":"2026-04-07T12:27:58Z","_id":"20741","title":"Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria","degree_awarded":"PhD","department":[{"_id":"GradSch"},{"_id":"MaLo"}],"date_created":"2025-12-09T13:08:11Z","publication_identifier":{"isbn":["978-3-99078-073-2"],"issn":["2663-337X"]},"OA_place":"publisher","publication_status":"published","fulldoi":"https://doi.org/10.15479/AT-ISTA-20741","oa_version":"Published Version","oa":1,"article_processing_charge":"No","corr_author":"1","has_accepted_license":"1","file_date_updated":"2025-12-10T13:09:58Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-12-09T00:00:00Z","citation":{"mla":"Kojic, Marko. <i>Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20741\">10.15479/AT-ISTA-20741</a>.","ista":"Kojic M. 2025. Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria. Institute of Science and Technology Austria.","apa":"Kojic, M. (2025). <i>Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20741\">https://doi.org/10.15479/AT-ISTA-20741</a>","short":"M. Kojic, Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria, Institute of Science and Technology Austria, 2025.","chicago":"Kojic, Marko. “Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20741\">https://doi.org/10.15479/AT-ISTA-20741</a>.","ama":"Kojic M. Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20741\">10.15479/AT-ISTA-20741</a>","ieee":"M. Kojic, “Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria,” Institute of Science and Technology Austria, 2025."},"related_material":{"record":[{"id":"15118","status":"public","relation":"part_of_dissertation"}]},"author":[{"last_name":"Kojic","first_name":"Marko","orcid":"0000-0001-7244-8128","full_name":"Kojic, Marko","id":"73e7ecd4-dc85-11ea-9058-88a16394b160"}],"status":"public","ddc":["572"],"month":"12","supervisor":[{"last_name":"Loose","orcid":"0000-0001-7309-9724","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin"}],"day":"09","doi":"10.15479/AT-ISTA-20741","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","alternative_title":["ISTA Thesis"]},{"citation":{"chicago":"Muñoz Hermosilla, José M, Evan Miles, Michael McCarthy, Florian Hardmeier, Juan Vicente Melo Velasco, Guillaume Jouvet, and Francesca Pellicciotti. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” In <i>EGU General Assembly 2025</i>. European Geosciences Union, 2025. <a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">https://doi.org/10.5194/egusphere-egu25-17446</a>.","mla":"Muñoz Hermosilla, José M., et al. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” <i>EGU General Assembly 2025</i>, EGU25-17446, European Geosciences Union, 2025, doi:<a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">10.5194/egusphere-egu25-17446</a>.","apa":"Muñoz Hermosilla, J. M., Miles, E., McCarthy, M., Hardmeier, F., Melo Velasco, J. V., Jouvet, G., &#38; Pellicciotti, F. (2025). Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In <i>EGU General Assembly 2025</i>. Vienna, Austria &#38; Virtual: European Geosciences Union. <a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">https://doi.org/10.5194/egusphere-egu25-17446</a>","ista":"Muñoz Hermosilla JM, Miles E, McCarthy M, Hardmeier F, Melo Velasco JV, Jouvet G, Pellicciotti F. 2025. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. EGU General Assembly 2025. EGU General Assembly, EGU25-17446.","short":"J.M. Muñoz Hermosilla, E. Miles, M. McCarthy, F. Hardmeier, J.V. Melo Velasco, G. Jouvet, F. Pellicciotti, in:, EGU General Assembly 2025, European Geosciences Union, 2025.","ieee":"J. M. Muñoz Hermosilla <i>et al.</i>, “Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier,” in <i>EGU General Assembly 2025</i>, Vienna, Austria &#38; Virtual, 2025.","ama":"Muñoz Hermosilla JM, Miles E, McCarthy M, et al. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In: <i>EGU General Assembly 2025</i>. European Geosciences Union; 2025. doi:<a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">10.5194/egusphere-egu25-17446</a>"},"has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-05-14T00:00:00Z","doi":"10.5194/egusphere-egu25-17446","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"14","main_file_link":[{"url":"https://doi.org/10.5194/egusphere-egu25-17446","open_access":"1"}],"author":[{"id":"e1037a6d-646e-11ef-b402-e0ed9ab0901e","orcid":"0000-0002-1990-8508","full_name":"Muñoz Hermosilla, José M","first_name":"José M","last_name":"Muñoz Hermosilla"},{"full_name":"Miles, Evan","first_name":"Evan","last_name":"Miles"},{"first_name":"Michael","id":"22a2674a-61ce-11ee-94b5-d18813baf16f","full_name":"McCarthy, Michael","last_name":"McCarthy"},{"first_name":"Florian","full_name":"Hardmeier, Florian","last_name":"Hardmeier"},{"last_name":"Melo Velasco","first_name":"Juan Vicente","id":"2611dec0-b9c6-11ed-9bea-a81c2b17a549","full_name":"Melo Velasco, Juan Vicente"},{"full_name":"Jouvet, Guillaume","first_name":"Guillaume","last_name":"Jouvet"},{"last_name":"Pellicciotti","first_name":"Francesca","orcid":"0000-0002-5554-8087","full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"}],"ddc":["550"],"status":"public","month":"05","publication":"EGU General Assembly 2025","conference":{"name":"EGU General Assembly","end_date":"2025-05-02","location":"Vienna, Austria & Virtual","start_date":"2025-04-27"},"date_updated":"2026-07-02T06:41:43Z","OA_type":"gold","article_number":"EGU25-17446","language":[{"iso":"eng"}],"year":"2025","type":"conference_abstract","publisher":"European Geosciences Union","oa":1,"article_processing_charge":"No","OA_place":"publisher","publication_status":"published","fulldoi":"https://doi.org/10.5194/egusphere-egu25-17446","oa_version":"Published Version","date_created":"2026-06-22T12:17:47Z","_id":"22120","title":"Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier","department":[{"_id":"FrPe"},{"_id":"GradSch"}]},{"related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"20465"}]},"status":"public","month":"10","ddc":["596","597","532"],"author":[{"first_name":"Suyash","id":"2C0B105C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8421-5508","full_name":"Naik, Suyash","last_name":"Naik"}],"day":"12","license":"https://creativecommons.org/licenses/by-sa/4.0/","supervisor":[{"last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hannezo","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B"}],"alternative_title":["ISTA Thesis"],"doi":"10.15479/AT-ISTA-20441","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","date_published":"2025-10-12T00:00:00Z","tmp":{"name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","short":"CC BY-SA (4.0)","image":"/images/cc_by_sa.png"},"has_accepted_license":"1","acknowledgement":"I would also like to thank the LSF and Cryo facility at ISTA, which have been helpful in my\r\nexperiments. I would also like to acknowledge FWF, grant DOI 10.55776/PAT5044023 and JKU Nanocell grant DOI \r\n10.55776/W1250 for providing funding for my PhD research. EMBO and FWF for providing funding for travel grants to attend conferences.","file_date_updated":"2025-10-28T13:10:26Z","citation":{"chicago":"Naik, Suyash. “Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>.","apa":"Naik, S. (2025). <i>Keratins act as global coordinators of tissue spreading through mechanosensitive feedback</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>","short":"S. Naik, Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback, Institute of Science and Technology Austria, 2025.","ista":"Naik S. 2025. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria.","mla":"Naik, Suyash. <i>Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>.","ama":"Naik S. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>","ieee":"S. Naik, “Keratins act as global coordinators of tissue spreading through mechanosensitive feedback,” Institute of Science and Technology Austria, 2025."},"department":[{"_id":"GradSch"},{"_id":"CaHe"},{"_id":"EdHa"}],"degree_awarded":"PhD","title":"Keratins act as global coordinators of tissue spreading through mechanosensitive feedback","_id":"20441","publication_identifier":{"isbn":["978-3-99078-069-5"],"issn":["2663-337X"]},"date_created":"2025-10-10T14:58:30Z","oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-20441","publication_status":"published","OA_place":"publisher","article_processing_charge":"No","oa":1,"publisher":"Institute of Science and Technology Austria","type":"dissertation","project":[{"_id":"8f060199-16d5-11f0-9cad-f3253b266c46","name":"Keratins in epithelial tissue spreading","grant_number":"PAT 5044023"},{"name":"Nano-Analytics of Cellular Systems","_id":"25AA5F24-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"W 1250-B20"}],"year":"2025","language":[{"iso":"eng"}],"abstract":[{"text":"Epithelial spreading plays a pivotal role in the development of organisms especially those\r\nsuch as zebrafish which require the epithelial enveloping layer (EVL) to spread to cover the\r\nsubstantial yolk surface during gastrulation. Epiboly requires the transition of the epithelium\r\nwith cuboidal cells to form a thin, flat squamous epithelial sheet. During this transition, the\r\ncells show tissue-scale mechanosensation with mechanisms such as direct mechanical control\r\nover the axis of cell division.\r\nCytoskeletal intermediate filaments play a crucial role in vertebrate cells, not only facilitating\r\nmechanical stability but also helping facilitate the mechanosensitive response of the cell.\r\nMechanosenstivity displayed by intermediate filaments is due not just to their interesting\r\nphysical properties but also to their interactions with other cytoskeletal elements such as actin\r\nand microtubules. Keratin is the predominant intermediate filament expressed in the EVL.\r\nIt expresses concomitantly with the gastrulation movements of the developing embryo. Our\r\nwork focuses on understanding the role and dynamics of the keratin cytoskeletal network in\r\nmodulating the physical aspects of EVL spreading. We demonstrated with the combination of\r\nphysical characterisation and manipulations of the EVL, utilising a variety of biophysical tools\r\nand microscopy, the mechanistic role of keratin in tissue spreading.\r\nGenerating novel genetic morphants and mutants, we probe the effect that the loss of the\r\nkeratin network has on the physiology of the epithelium and the developing embryo. We\r\nshow that the changing organisation of the keratin network is important for changing EVL\r\nphysical properties as the stress imposed on the EVL increases during epiboly. By modelling\r\nthe epithelium, we study how the mechanical heterogeneity in an epithelium can feed back into\r\na mechanical loop to the maturation of the keratin network and hence affect the mechanics\r\nof the epithelium. However, unlike what would be predicted by the effect of intermediate\r\nfilaments in acting as a security belt and increasing the resistance of the epithelium, we observe\r\nthat loss of keratin leads to a delay in the EVL movement. Using both local aspirations of the\r\nYSL and EVL ablations, we demonstrate the mechanistic facilitation of actin mechanosensation\r\nin a keratin-dependent manner.\r\nFurthermore, using chemical inhibitors of microtubule polymerisation, we provide insight into\r\nthe mechanisms underlying the organisation and distribution of keratin. Interestingly, the\r\nphenotype observed upon this loss of microtubules shows that keratins interact with the nucleus\r\nthrough microtubular interactions. Together with these diverse observations, we describe\r\nthe mechanosensory feedback between resilience and that is critical for uniform and robust\r\nspreading of the epithelium.","lang":"eng"}],"page":"105","date_updated":"2026-07-06T12:51:41Z","file":[{"success":1,"file_size":6846189,"date_created":"2025-10-28T13:10:08Z","creator":"snaik","file_id":"20567","checksum":"2892f04d4a5c18677871c3e06ac1244a","content_type":"application/pdf","date_updated":"2025-10-28T13:10:08Z","relation":"main_file","access_level":"open_access","file_name":"Thesis_PDFA_.pdf"},{"relation":"source_file","date_updated":"2025-10-28T13:10:26Z","access_level":"open_access","file_name":"Thesis.zip","creator":"snaik","file_id":"20568","content_type":"application/zip","checksum":"15934d4465cd0e9b7c32678da9a33a2f","file_size":8839300,"date_created":"2025-10-28T13:10:26Z"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}]},{"article_processing_charge":"No","oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-19478","publication_status":"published","OA_place":"publisher","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-04-04T07:48:24Z","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"degree_awarded":"PhD","title":"The cAMP second messenger in auxin signalling","_id":"19478","date_updated":"2026-07-06T12:58:58Z","file":[{"date_created":"2025-04-08T08:00:07Z","file_size":16344814,"relation":"source_file","date_updated":"2025-04-08T08:22:37Z","file_name":"Thesis_0403_Huihuang.docx","access_level":"closed","file_id":"19526","checksum":"b154973663a1bba505683faab7ae5ead","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"hchen"},{"relation":"main_file","date_updated":"2025-04-09T13:53:38Z","file_name":"Thesis_0406_PDFA_Huihuang_1.pdf","access_level":"closed","creator":"hchen","embargo_to":"local","file_id":"19527","content_type":"application/pdf","checksum":"0099565f024388830c125ec17375c1a0","file_size":8482147,"date_created":"2025-04-08T08:00:06Z","embargo":"2026-10-08"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"page":"118","publisher":"Institute of Science and Technology Austria","type":"dissertation","year":"2025","project":[{"call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"},{"grant_number":"P37051","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors"},{"grant_number":"101142681","name":"Cyclic nucleotides as second messengers in plants","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"}],"language":[{"iso":"eng"}],"alternative_title":["ISTA Thesis"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/AT-ISTA-19478","day":"04","supervisor":[{"first_name":"Jiří","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"status":"public","month":"04","ddc":["580"],"author":[{"last_name":"Chen","id":"83c96512-15b2-11ec-abd3-b7eede36184f","full_name":"Chen, Huihuang","first_name":"Huihuang"}],"related_material":{"record":[{"id":"19421","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"13212"}]},"ec_funded":1,"citation":{"ieee":"H. Chen, “The cAMP second messenger in auxin signalling,” Institute of Science and Technology Austria, 2025.","ama":"Chen H. The cAMP second messenger in auxin signalling. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>","ista":"Chen H. 2025. The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria.","short":"H. Chen, The CAMP Second Messenger in Auxin Signalling, Institute of Science and Technology Austria, 2025.","apa":"Chen, H. (2025). <i>The cAMP second messenger in auxin signalling</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>","mla":"Chen, Huihuang. <i>The CAMP Second Messenger in Auxin Signalling</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>.","chicago":"Chen, Huihuang. “The CAMP Second Messenger in Auxin Signalling.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>."},"date_published":"2025-04-04T00:00:00Z","has_accepted_license":"1","acknowledgement":"This project was funded by the European Research Council Advanced Grant (ETAP-742985),\r\nEuropean Research Council (ERC; 101142681 CYNIPS), Austrian Science Fund (FWF; P\r\n37051-B).","file_date_updated":"2025-04-09T13:53:38Z","corr_author":"1"},{"corr_author":"1","has_accepted_license":"1","file_date_updated":"2026-01-02T10:39:26Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"date_published":"2025-12-31T00:00:00Z","citation":{"ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>","ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>.","short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>","mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>."},"related_material":{"record":[{"id":"13143","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"12176"},{"relation":"earlier_version","status":"public","id":"20556"},{"relation":"part_of_dissertation","status":"public","id":"19778"},{"id":"20701","status":"public","relation":"part_of_dissertation"}]},"author":[{"full_name":"Hoffmann, Charlotte","orcid":"0000-0003-2027-5549","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7","first_name":"Charlotte","last_name":"Hoffmann"}],"month":"12","status":"public","ddc":["004"],"supervisor":[{"last_name":"Pietrzak","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9139-1654","full_name":"Pietrzak, Krzysztof Z","first_name":"Krzysztof Z"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","day":"31","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/AT-ISTA-20920","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}],"year":"2025","type":"dissertation","publisher":"Institute of Science and Technology Austria","page":"116","abstract":[{"lang":"eng","text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications."}],"file":[{"creator":"choffman","file_id":"20921","content_type":"application/x-zip-compressed","checksum":"8a099fbf54963bd0be38f7ce73658682","relation":"source_file","date_updated":"2026-01-02T10:39:16Z","file_name":"2025_Hoffmann_Charlotte_Source.zip","access_level":"closed","file_size":8355494,"date_created":"2026-01-02T10:39:16Z"},{"access_level":"open_access","file_name":"2025_Hoffmann_Charlotte_Thesis.pdf","relation":"main_file","date_updated":"2026-01-02T10:39:26Z","content_type":"application/pdf","checksum":"9521c07bfb2bb5b14a49c09fcfc96474","file_id":"20922","creator":"choffman","date_created":"2026-01-02T10:39:26Z","file_size":2258804,"success":1}],"date_updated":"2026-07-06T13:15:27Z","_id":"20920","title":"Theory and applications of verifiable delay functions","degree_awarded":"PhD","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"date_created":"2026-01-02T10:46:47Z","publication_identifier":{"issn":["2663-337X"]},"OA_place":"publisher","publication_status":"published","fulldoi":"https://doi.org/10.15479/AT-ISTA-20920","oa_version":"Published Version","oa":1,"article_processing_charge":"No"},{"abstract":[{"lang":"eng","text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications."}],"page":"116","date_updated":"2026-07-06T13:15:27Z","file":[{"file_id":"20573","checksum":"1fffa4e2c33dd0b9f883d615504a2858","content_type":"application/pdf","creator":"choffman","relation":"main_file","date_updated":"2026-01-08T14:11:39Z","access_level":"closed","file_name":"2025_Hoffmann_Charlotte_Thesis.pdf","date_created":"2025-10-28T14:33:03Z","file_size":2259304},{"date_updated":"2025-11-11T09:34:54Z","relation":"source_file","file_name":"2025_Hoffmann_Charlotte_Source.zip","access_level":"closed","file_id":"20574","content_type":"application/x-zip-compressed","checksum":"076ea98a1f0a86c3bbc990b6b9460dc2","creator":"choffman","date_created":"2025-10-28T14:35:06Z","file_size":9987633}],"type":"dissertation","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"year":"2025","fulldoi":"https://doi.org/10.15479/AT-ISTA-20556","oa_version":"Published Version","OA_place":"publisher","publication_status":"published","article_processing_charge":"No","degree_awarded":"PhD","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"_id":"20556","title":"Theory and applications of verifiable delay functions","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-10-27T14:16:56Z","citation":{"ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>","mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>.","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>.","ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>"},"corr_author":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"date_published":"2025-10-31T00:00:00Z","file_date_updated":"2026-01-08T14:11:39Z","has_accepted_license":"1","day":"31","supervisor":[{"first_name":"Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654","last_name":"Pietrzak"}],"alternative_title":["ISTA Thesis"],"doi":"10.15479/AT-ISTA-20556","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"13143"},{"id":"12176","relation":"part_of_dissertation","status":"public"},{"id":"20920","status":"public","relation":"later_version"},{"relation":"part_of_dissertation","status":"public","id":"19778"},{"id":"20701","relation":"part_of_dissertation","status":"public"}]},"author":[{"last_name":"Hoffmann","first_name":"Charlotte","full_name":"Hoffmann, Charlotte","orcid":"0000-0003-2027-5549","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7"}],"month":"10","status":"public","ddc":["004"]},{"title":"The neural basis of species-specific defensive behaviour in Peromyscus mice","_id":"20101","department":[{"_id":"GradSch"}],"date_created":"2025-08-03T22:01:31Z","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"publication_status":"published","OA_place":"publisher","oa_version":"Published Version","fulldoi":"https://doi.org/10.1038/s41586-025-09241-2","pmid":1,"oa":1,"article_processing_charge":"Yes (in subscription journal)","year":"2025","language":[{"iso":"eng"}],"publisher":"Springer Nature","type":"journal_article","volume":645,"page":"439-447","abstract":[{"lang":"eng","text":"Evading imminent threat from predators is critical for animal survival. Effective defensive strategies can vary, even between closely related species. However, the neural basis of such species-specific behaviours remains poorly understood1,2,3,4. Here we find that two sister species of deer mice (genus Peromyscus)5 show different responses to the same looming stimulus: Peromyscus maniculatus, which occupies densely vegetated habitats, predominantly escapes, whereas the open field specialist, Peromyscus polionotus, briefly freezes. This difference arises from species-specific escape thresholds, is largely context-independent, and can be triggered by both visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological recordings, we find that although visual threat activates the superior colliculus in both species, the role of the dorsal periaqueductal grey (dPAG) in driving behaviour differs. Whereas dPAG activity scales with running speed in P. maniculatus, neural activity in the dPAG of P. polionotus correlates poorly with movement, including during visually triggered escape. Moreover, optogenetic activation of dPAG neurons elicits acceleration in P. maniculatus but not in P. polionotus, and their chemogenetic inhibition during a looming stimulus delays escape onset in P. maniculatus to match that of P. polionotus. Together, we trace species-specific escape thresholds to a central circuit node, downstream of peripheral sensory neurons, localizing an ecologically relevant behavioural difference to a specific region of the mammalian brain."}],"file":[{"file_size":53301589,"date_created":"2025-12-30T07:39:45Z","success":1,"relation":"main_file","date_updated":"2025-12-30T07:39:45Z","access_level":"open_access","file_name":"2025_Nature_Baier.pdf","creator":"dernst","file_id":"20884","content_type":"application/pdf","checksum":"7ea846a7a49b3b2a248f6a27ab13d591"}],"OA_type":"hybrid","date_updated":"2026-07-22T06:20:09Z","intvolume":"       645","quality_controlled":"1","related_material":{"record":[{"status":"public","relation":"research_data","id":"20883"}]},"publication":"Nature","status":"public","ddc":["570"],"month":"07","author":[{"last_name":"Baier","full_name":"Baier, Felix","first_name":"Felix"},{"last_name":"Reinhard","first_name":"Katja","full_name":"Reinhard, Katja"},{"full_name":"Nuttin, Bram","first_name":"Bram","last_name":"Nuttin"},{"first_name":"Arnau","full_name":"Sans-Dublanc, Arnau","last_name":"Sans-Dublanc"},{"full_name":"Liu, Chen","first_name":"Chen","last_name":"Liu"},{"full_name":"Tong, Victoria","first_name":"Victoria","last_name":"Tong"},{"last_name":"Murmann","first_name":"Julie Stefanie","id":"1d390868-f128-11eb-9611-a0ca5f7833b5","full_name":"Murmann, Julie Stefanie"},{"full_name":"Wierda, Keimpe","first_name":"Keimpe","last_name":"Wierda"},{"first_name":"Karl","full_name":"Farrow, Karl","last_name":"Farrow"},{"last_name":"Hoekstra","full_name":"Hoekstra, Hopi E.","first_name":"Hopi E."}],"day":"23","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s41586-025-09241-2","external_id":{"pmid":["40702175"]},"file_date_updated":"2025-12-30T07:39:45Z","has_accepted_license":"1","acknowledgement":"The authors thank M. Yilmaz, M. Meister, M. Joesch and T. Branco for advice on the behavioural experiments; C. Dulac, V. Bitsikas, E. Diel and J. Chen for advice on the immunohistochemistry and RNAscope experiments; J. Greenwood and E. Soucy for technical and engineering help; A. Chrzanowska for help and advice on optogenetic experiments; A. Calzoni for help aligning histological sections to a brain atlas; S. Worthington for statistical advice; P. Gonçalves for advice with the electrophysiology analysis; I. Vlaemick for help with whole cell experiments; R. Hellmiss for figure design; B. Sabatini, V. Stempel, K. Tyssowski and N. Sanguinetti for feedback on the manuscript; and Y. M. Lee and A. Tomcho for photos of P. maniculatus and P. leucopus habitats (Fig. 1). F.B. was supported by an HHMI International Student Research Fellowship, a Grant-in-Aid of the American Society of Mammalogy, a Herchel Smith Graduate Fellowship, a Robert A. Chapman Memorial Scholarship, and a Joan Brockman Williamson Fellowship. This project received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 665501 and by the FWO (12S7917N and 12S7920N) to K.R. and from European Research Council (ERC) (grant agreement 101075848) to K.R. V.T. was supported by a Harvard PRISE fellowship and a Harvard Museum of Comparative Zoology grant for undergraduate research. K.F. is supported by the FWO (G094616N and G091719N) and the NIH (1R01EY032101). This work was supported by the Howard Hughes Medical Institute, of which H.E.H. was an Investigator.","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)"},"date_published":"2025-07-23T00:00:00Z","citation":{"ama":"Baier F, Reinhard K, Nuttin B, et al. The neural basis of species-specific defensive behaviour in Peromyscus mice. <i>Nature</i>. 2025;645:439-447. doi:<a href=\"https://doi.org/10.1038/s41586-025-09241-2\">10.1038/s41586-025-09241-2</a>","ieee":"F. Baier <i>et al.</i>, “The neural basis of species-specific defensive behaviour in Peromyscus mice,” <i>Nature</i>, vol. 645. Springer Nature, pp. 439–447, 2025.","apa":"Baier, F., Reinhard, K., Nuttin, B., Sans-Dublanc, A., Liu, C., Tong, V., … Hoekstra, H. E. (2025). The neural basis of species-specific defensive behaviour in Peromyscus mice. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-09241-2\">https://doi.org/10.1038/s41586-025-09241-2</a>","short":"F. Baier, K. Reinhard, B. Nuttin, A. Sans-Dublanc, C. Liu, V. Tong, J.S. Murmann, K. Wierda, K. Farrow, H.E. Hoekstra, Nature 645 (2025) 439–447.","ista":"Baier F, Reinhard K, Nuttin B, Sans-Dublanc A, Liu C, Tong V, Murmann JS, Wierda K, Farrow K, Hoekstra HE. 2025. The neural basis of species-specific defensive behaviour in Peromyscus mice. Nature. 645, 439–447.","mla":"Baier, Felix, et al. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” <i>Nature</i>, vol. 645, Springer Nature, 2025, pp. 439–47, doi:<a href=\"https://doi.org/10.1038/s41586-025-09241-2\">10.1038/s41586-025-09241-2</a>.","chicago":"Baier, Felix, Katja Reinhard, Bram Nuttin, Arnau Sans-Dublanc, Chen Liu, Victoria Tong, Julie Stefanie Murmann, Keimpe Wierda, Karl Farrow, and Hopi E. Hoekstra. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-09241-2\">https://doi.org/10.1038/s41586-025-09241-2</a>."},"scopus_import":"1"},{"_id":"20883","related_material":{"record":[{"id":"20101","status":"public","relation":"used_in_publication"}]},"title":"The neural basis of species-specific defensive behaviour in Peromyscus mice","department":[{"_id":"GradSch"}],"main_file_link":[{"url":"https://doi.org/10.5061/dryad.q2bvq83xc","open_access":"1"}],"date_created":"2025-12-30T07:36:29Z","author":[{"first_name":"Baier","full_name":"Felix, Baier","last_name":"Felix"},{"last_name":"Reinhard","first_name":"Katja","full_name":"Reinhard, Katja"},{"first_name":"Bram","full_name":"Nuttin, Bram","last_name":"Nuttin"},{"last_name":"Sans Dublanc","first_name":"Arnau","full_name":"Sans Dublanc, Arnau"},{"first_name":"Chen","full_name":"Liu, Chen","last_name":"Liu"},{"first_name":"Victoria","full_name":"Tong, Victoria","last_name":"Tong"},{"id":"1d390868-f128-11eb-9611-a0ca5f7833b5","full_name":"Murmann, Julie Stefanie","first_name":"Julie Stefanie","last_name":"Murmann"},{"last_name":"Wierda","first_name":"Keimpe","full_name":"Wierda, Keimpe"},{"last_name":"Farrow","full_name":"Farrow, Karl","first_name":"Karl"},{"last_name":"Hoekstra","full_name":"Hoekstra, Hopi","first_name":"Hopi"}],"month":"06","status":"public","OA_place":"repository","fulldoi":"https://doi.org/10.5061/DRYAD.Q2BVQ83XC","day":"23","oa_version":"Published Version","doi":"10.5061/DRYAD.Q2BVQ83XC","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","year":"2025","date_published":"2025-06-23T00:00:00Z","type":"research_data_reference","publisher":"Dryad","citation":{"ama":"Felix B, Reinhard K, Nuttin B, et al. The neural basis of species-specific defensive behaviour in Peromyscus mice. 2025. doi:<a href=\"https://doi.org/10.5061/DRYAD.Q2BVQ83XC\">10.5061/DRYAD.Q2BVQ83XC</a>","ieee":"B. Felix <i>et al.</i>, “The neural basis of species-specific defensive behaviour in Peromyscus mice.” Dryad, 2025.","short":"B. Felix, K. Reinhard, B. Nuttin, A. Sans Dublanc, C. Liu, V. Tong, J.S. Murmann, K. Wierda, K. Farrow, H. Hoekstra, (2025).","apa":"Felix, B., Reinhard, K., Nuttin, B., Sans Dublanc, A., Liu, C., Tong, V., … Hoekstra, H. (2025). The neural basis of species-specific defensive behaviour in Peromyscus mice. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.Q2BVQ83XC\">https://doi.org/10.5061/DRYAD.Q2BVQ83XC</a>","ista":"Felix B, Reinhard K, Nuttin B, Sans Dublanc A, Liu C, Tong V, Murmann JS, Wierda K, Farrow K, Hoekstra H. 2025. The neural basis of species-specific defensive behaviour in Peromyscus mice, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.Q2BVQ83XC\">10.5061/DRYAD.Q2BVQ83XC</a>.","mla":"Felix, Baier, et al. <i>The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice</i>. Dryad, 2025, doi:<a href=\"https://doi.org/10.5061/DRYAD.Q2BVQ83XC\">10.5061/DRYAD.Q2BVQ83XC</a>.","chicago":"Felix, Baier, Katja Reinhard, Bram Nuttin, Arnau Sans Dublanc, Chen Liu, Victoria Tong, Julie Stefanie Murmann, Keimpe Wierda, Karl Farrow, and Hopi Hoekstra. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” Dryad, 2025. <a href=\"https://doi.org/10.5061/DRYAD.Q2BVQ83XC\">https://doi.org/10.5061/DRYAD.Q2BVQ83XC</a>."},"abstract":[{"lang":"eng","text":"Evading imminent predator threat is critical for survival. Effective defensive strategies can vary, even between closely related species. However, the neural basis of such species-specific behaviours is still poorly understood. Here we find that two sister species of deer mice (genus Peromyscus) show different responses to the same looming stimulus: P. maniculatus, which occupies densely vegetated habitats, predominantly escapes, while the open field specialist, P. polionotus, briefly freezes. This difference arises from species-specific escape thresholds, is largely context-independent, and can be triggered by both visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological recordings, we find that although visual threat activates the superior colliculus in both species, the role of the dorsal periaqueductal gray (dPAG) in driving behaviour differs. While dPAG activity scales with running speed in P. maniculatus, neural activity in the dPAG of P. polionotus correlates poorly with movement, including during visually triggered escape. Moreover, optogenetic activation of dPAG neurons elicits acceleration in P. maniculatus but not P. polionotus, while their chemogenetic inhibition during a looming stimulus delays escape onset in P. maniculatus to match that of P. polionotus. Together, we trace species-specific escape thresholds to a central circuit node, downstream of peripheral sensory neurons, localizing an ecologically relevant behavioural difference to a specific region of the mammalian brain."}],"OA_type":"hybrid","date_updated":"2026-07-22T06:20:09Z"},{"department":[{"_id":"GradSch"},{"_id":"VlKo"}],"_id":"21399","title":"The equational theories project: Advancing collaborative mathematical research at scale","date_created":"2026-03-04T12:00:16Z","fulldoi":"https://doi.org/10.48550/arXiv.2512.07087","oa_version":"Preprint","OA_place":"repository","publication_status":"submitted","article_processing_charge":"No","oa":1,"type":"preprint","language":[{"iso":"eng"}],"year":"2025","abstract":[{"lang":"eng","text":"We report on the Equational Theories Project (ETP), an online collaborative pilot project to explore new ways to collaborate in mathematics with machine assistance. The project successfully determined all 22 028 942 edges of the implication graph between the 4694 simplest equational laws on magmas, by a combination of human-generated and automated proofs, all validated by the formal proof assistant language Lean. As a result of this project, several new constructions of magmas satisfying specific laws were discovered, and several auxiliary questions were also addressed, such as the effect of restricting attention to finite magmas."}],"arxiv":1,"article_number":"2512.07087","date_updated":"2026-07-22T06:35:39Z","OA_type":"green","publication":"arXiv","author":[{"full_name":"Bolan, Matthew","first_name":"Matthew","last_name":"Bolan"},{"first_name":"Joachim","full_name":"Breitner, Joachim","last_name":"Breitner"},{"last_name":"Brox","full_name":"Brox, Jose","first_name":"Jose"},{"first_name":"Nicholas","full_name":"Carlini, Nicholas","last_name":"Carlini"},{"last_name":"Carneiro","full_name":"Carneiro, Mario","first_name":"Mario"},{"last_name":"Doorn","full_name":"Doorn, Floris van","first_name":"Floris van"},{"last_name":"Dvorak","first_name":"Martin","orcid":"0000-0001-5293-214X","full_name":"Dvorak, Martin","id":"40ED02A8-C8B4-11E9-A9C0-453BE6697425"},{"full_name":"Goens, Andrés","first_name":"Andrés","last_name":"Goens"},{"last_name":"Hill","first_name":"Aaron","full_name":"Hill, Aaron"},{"last_name":"Husum","full_name":"Husum, Harald","first_name":"Harald"},{"first_name":"Hernán Ibarra","full_name":"Mejia, Hernán Ibarra","last_name":"Mejia"},{"full_name":"Kocsis, Zoltan A.","first_name":"Zoltan A.","last_name":"Kocsis"},{"first_name":"Bruno Le","full_name":"Floch, Bruno Le","last_name":"Floch"},{"last_name":"Bar-on","full_name":"Bar-on, Amir","first_name":"Amir"},{"first_name":"Lorenzo","full_name":"Luccioli, Lorenzo","last_name":"Luccioli"},{"first_name":"Douglas","full_name":"McNeil, Douglas","last_name":"McNeil"},{"first_name":"Alex","full_name":"Meiburg, Alex","last_name":"Meiburg"},{"full_name":"Monticone, Pietro","first_name":"Pietro","last_name":"Monticone"},{"first_name":"Pace P.","full_name":"Nielsen, Pace P.","last_name":"Nielsen"},{"full_name":"Osazuwa, Emmanuel Osalotioman","first_name":"Emmanuel Osalotioman","last_name":"Osazuwa"},{"full_name":"Paolini, Giovanni","first_name":"Giovanni","last_name":"Paolini"},{"last_name":"Petracci","first_name":"Marco","full_name":"Petracci, Marco"},{"last_name":"Reinke","full_name":"Reinke, Bernhard","first_name":"Bernhard"},{"last_name":"Renshaw","first_name":"David","full_name":"Renshaw, David"},{"last_name":"Rossel","first_name":"Marcus","full_name":"Rossel, Marcus"},{"full_name":"Roux, Cody","first_name":"Cody","last_name":"Roux"},{"last_name":"Scanvic","full_name":"Scanvic, Jérémy","first_name":"Jérémy"},{"full_name":"Srinivas, Shreyas","first_name":"Shreyas","last_name":"Srinivas"},{"first_name":"Anand Rao","full_name":"Tadipatri, Anand Rao","last_name":"Tadipatri"},{"last_name":"Tao","full_name":"Tao, Terence","first_name":"Terence"},{"last_name":"Tsyrklevich","full_name":"Tsyrklevich, Vlad","first_name":"Vlad"},{"full_name":"Vaquerizo-Villar, Fernando","first_name":"Fernando","last_name":"Vaquerizo-Villar"},{"first_name":"Daniel","full_name":"Weber, Daniel","last_name":"Weber"},{"first_name":"Fan","full_name":"Zheng, Fan","last_name":"Zheng"}],"month":"12","status":"public","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2512.07087","open_access":"1"}],"day":"16","doi":"10.48550/arXiv.2512.07087","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2512.07087"]},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-12-16T00:00:00Z","citation":{"ieee":"M. Bolan <i>et al.</i>, “The equational theories project: Advancing collaborative mathematical research at scale,” <i>arXiv</i>. .","ama":"Bolan M, Breitner J, Brox J, et al. The equational theories project: Advancing collaborative mathematical research at scale. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2512.07087\">10.48550/arXiv.2512.07087</a>","chicago":"Bolan, Matthew, Joachim Breitner, Jose Brox, Nicholas Carlini, Mario Carneiro, Floris van Doorn, Martin Dvorak, et al. “The Equational Theories Project: Advancing Collaborative Mathematical Research at Scale.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2512.07087\">https://doi.org/10.48550/arXiv.2512.07087</a>.","apa":"Bolan, M., Breitner, J., Brox, J., Carlini, N., Carneiro, M., Doorn, F. van, … Zheng, F. (n.d.). The equational theories project: Advancing collaborative mathematical research at scale. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2512.07087\">https://doi.org/10.48550/arXiv.2512.07087</a>","ista":"Bolan M, Breitner J, Brox J, Carlini N, Carneiro M, Doorn F van, Dvorak M, Goens A, Hill A, Husum H, Mejia HI, Kocsis ZA, Floch BL, Bar-on A, Luccioli L, McNeil D, Meiburg A, Monticone P, Nielsen PP, Osazuwa EO, Paolini G, Petracci M, Reinke B, Renshaw D, Rossel M, Roux C, Scanvic J, Srinivas S, Tadipatri AR, Tao T, Tsyrklevich V, Vaquerizo-Villar F, Weber D, Zheng F. The equational theories project: Advancing collaborative mathematical research at scale. arXiv, 2512.07087.","short":"M. Bolan, J. Breitner, J. Brox, N. Carlini, M. Carneiro, F. van Doorn, M. Dvorak, A. Goens, A. Hill, H. Husum, H.I. Mejia, Z.A. Kocsis, B.L. Floch, A. Bar-on, L. Luccioli, D. McNeil, A. Meiburg, P. Monticone, P.P. Nielsen, E.O. Osazuwa, G. Paolini, M. Petracci, B. Reinke, D. Renshaw, M. Rossel, C. Roux, J. Scanvic, S. Srinivas, A.R. Tadipatri, T. Tao, V. Tsyrklevich, F. Vaquerizo-Villar, D. Weber, F. Zheng, ArXiv (n.d.).","mla":"Bolan, Matthew, et al. “The Equational Theories Project: Advancing Collaborative Mathematical Research at Scale.” <i>ArXiv</i>, 2512.07087, doi:<a href=\"https://doi.org/10.48550/arXiv.2512.07087\">10.48550/arXiv.2512.07087</a>."},"das_tickbox":"1"},{"publication_status":"draft","OA_place":"repository","oa_version":"Preprint","fulldoi":"https://doi.org/10.48550/arXiv.2502.06560","oa":1,"article_processing_charge":"No","title":"Position: It's time to act on the risk of efficient personalized text generation","_id":"21858","department":[{"_id":"GradSch"},{"_id":"DaAl"}],"date_created":"2026-05-11T08:55:23Z","arxiv":1,"abstract":[{"lang":"eng","text":"The recent surge in high-quality open-source Generative AI text models (colloquially: LLMs), as well as efficient finetuning techniques, have opened the possibility of creating high-quality personalized models that generate text attuned to a specific individual’s needs and are capable of credibly imitating their writing style by refining an open-source model with that person’s own data. The technology to create such models is accessible to private individuals, and training and running such models can be done cheaply on consumer-grade hardware. While these advancements are a huge gain for usability and privacy, this position paper argues that the practical feasibility of impersonating specific individuals also introduces novel safety risks. For instance, this technology enables the creation of phishing emails\r\nor fraudulent social media accounts, based on small amounts of publicly available text, or by the individuals themselves to escape AI text detection. We further argue that these risks are complementary to—and distinct from—the much-discussed risks of other impersonation attacks such as image, voice, or video deepfakes, and are not adequately addressed by the larger research community, or the current generation of open- and closed-source models."}],"OA_type":"green","date_updated":"2026-07-27T12:50:03Z","project":[{"name":"FastML: Efficient and Cost-Effective Distributed Machine Learning","_id":"8e35c14b-16d5-11f0-9cad-a3fc35339161","grant_number":"101158077"},{"_id":"9B9290DE-BA93-11EA-9121-9846C619BF3A","name":"Vienna Graduate School on Computational Optimization","grant_number":"W1260-N35"}],"year":"2025","language":[{"iso":"eng"}],"type":"preprint","day":"02","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","doi":"10.48550/arXiv.2502.06560","related_material":{"record":[{"id":"21854","status":"public","relation":"dissertation_contains"}]},"publication":"arXiv","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2502.06560","open_access":"1"}],"status":"public","month":"06","author":[{"last_name":"Iofinova","first_name":"Eugenia B","id":"f9a17499-f6e0-11ea-865d-fdf9a3f77117","orcid":"0000-0002-7778-3221","full_name":"Iofinova, Eugenia B"},{"last_name":"Jovanovic","first_name":"Andrej","full_name":"Jovanovic, Andrej"},{"last_name":"Alistarh","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3650-940X","full_name":"Alistarh, Dan-Adrian","first_name":"Dan-Adrian"}],"citation":{"chicago":"Iofinova, Eugenia B, Andrej Jovanovic, and Dan-Adrian Alistarh. “Position: It’s Time to Act on the Risk of Efficient Personalized Text Generation.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2502.06560\">https://doi.org/10.48550/arXiv.2502.06560</a>.","ista":"Iofinova EB, Jovanovic A, Alistarh D-A. Position: It’s time to act on the risk of efficient personalized text generation. arXiv, <a href=\"https://doi.org/10.48550/arXiv.2502.06560\">10.48550/arXiv.2502.06560</a>.","apa":"Iofinova, E. B., Jovanovic, A., &#38; Alistarh, D.-A. (n.d.). Position: It’s time to act on the risk of efficient personalized text generation. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2502.06560\">https://doi.org/10.48550/arXiv.2502.06560</a>","short":"E.B. Iofinova, A. Jovanovic, D.-A. Alistarh, ArXiv (n.d.).","mla":"Iofinova, Eugenia B., et al. “Position: It’s Time to Act on the Risk of Efficient Personalized Text Generation.” <i>ArXiv</i>, doi:<a href=\"https://doi.org/10.48550/arXiv.2502.06560\">10.48550/arXiv.2502.06560</a>.","ama":"Iofinova EB, Jovanovic A, Alistarh D-A. Position: It’s time to act on the risk of efficient personalized text generation. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2502.06560\">10.48550/arXiv.2502.06560</a>","ieee":"E. B. Iofinova, A. Jovanovic, and D.-A. Alistarh, “Position: It’s time to act on the risk of efficient personalized text generation,” <i>arXiv</i>. ."},"external_id":{"arxiv":["2502.06560"]},"corr_author":"1","acknowledgement":"This research was supported by the Scientific Service Units (SSU) of IST Austria through resources\r\nprovided by Scientific Computing (SciComp). EI was supported in part by the FWF DK VGSCO,\r\ngrant agreement number W1260-N35. AJ was supported in part by ERC Proof-of-Concept Grant\r\nFastML, grant agreement 101158077.","date_published":"2025-06-02T00:00:00Z"},{"citation":{"ista":"Kolmogorov V, Naldi S, Zapata J. 2025. Certifying solutions of degenerate semidefinite programs. SIAM Journal on Optimization. 35(3), 1630–1654.","apa":"Kolmogorov, V., Naldi, S., &#38; Zapata, J. (2025). Certifying solutions of degenerate semidefinite programs. <i>SIAM Journal on Optimization</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/24m1664691\">https://doi.org/10.1137/24m1664691</a>","short":"V. Kolmogorov, S. Naldi, J. Zapata, SIAM Journal on Optimization 35 (2025) 1630–1654.","mla":"Kolmogorov, Vladimir, et al. “Certifying Solutions of Degenerate Semidefinite Programs.” <i>SIAM Journal on Optimization</i>, vol. 35, no. 3, Society for Industrial and Applied Mathematics, 2025, pp. 1630–54, doi:<a href=\"https://doi.org/10.1137/24m1664691\">10.1137/24m1664691</a>.","chicago":"Kolmogorov, Vladimir, Simone Naldi, and Jeferson Zapata. “Certifying Solutions of Degenerate Semidefinite Programs.” <i>SIAM Journal on Optimization</i>. Society for Industrial and Applied Mathematics, 2025. <a href=\"https://doi.org/10.1137/24m1664691\">https://doi.org/10.1137/24m1664691</a>.","ieee":"V. Kolmogorov, S. Naldi, and J. Zapata, “Certifying solutions of degenerate semidefinite programs,” <i>SIAM Journal on Optimization</i>, vol. 35, no. 3. Society for Industrial and Applied Mathematics, pp. 1630–1654, 2025.","ama":"Kolmogorov V, Naldi S, Zapata J. Certifying solutions of degenerate semidefinite programs. <i>SIAM Journal on Optimization</i>. 2025;35(3):1630-1654. doi:<a href=\"https://doi.org/10.1137/24m1664691\">10.1137/24m1664691</a>"},"date_published":"2025-09-01T00:00:00Z","external_id":{"arxiv":["2405.13625"]},"doi":"10.1137/24m1664691","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","article_type":"original","status":"public","month":"09","author":[{"full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir","last_name":"Kolmogorov"},{"last_name":"Naldi","first_name":"Simone","full_name":"Naldi, Simone"},{"full_name":"Zapata, Jeferson","id":"00223538-AF8F-11E9-A4C7-F729E6697425","first_name":"Jeferson","last_name":"Zapata"}],"issue":"3","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2405.13625","open_access":"1"}],"publication":"SIAM Journal on Optimization","quality_controlled":"1","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"21957"}]},"OA_type":"green","date_updated":"2026-07-27T14:30:41Z","intvolume":"        35","abstract":[{"lang":"eng","text":"This paper deals with the algorithmic aspects of solving feasibility problems of semidefinite programming (SDP), aka linear matrix inequalities (LMIs). Since in some SDP instances all feasible solutions have irrational entries, numerical solvers that work with rational numbers can only find an approximate solution. We study the following question: Is it possible to certify feasibility of a given SDP using an approximate solution that is sufficiently close to some exact solution? Existing approaches make the assumption that there exist rational feasible solutions (and use techniques such as rounding and lattice reduction algorithms). We propose an alternative approach that does not need this assumption. More specifically, we show how to construct a system of polynomial equations whose set of real solutions is guaranteed to have an isolated correct solution (assuming that the target exact solution is maximum-rank). This allows, in particular, for us to use algorithms from real algebraic geometry for solving systems of polynomial equations, yielding a hybrid (or symbolic-numerical) method for SDPs. We experimentally compare it with a pure symbolic method in [D. Henrion, S. Naldi, and M. Safey El Din, SIAM J. Optim., 26 (2016), pp. 2512–2539]; the hybrid method was able to certify feasibility of many SDP instances on which the aforementioned paper failed. Our approach may have further applications, such as refining an approximate solution using methods of numerical algebraic geometry for systems of polynomial equations."}],"arxiv":1,"volume":35,"page":"1630-1654","publisher":"Society for Industrial and Applied Mathematics","type":"journal_article","year":"2025","language":[{"iso":"eng"}],"article_processing_charge":"No","oa":1,"oa_version":"Preprint","fulldoi":"https://doi.org/10.1137/24m1664691","publication_status":"published","OA_place":"repository","publication_identifier":{"issn":["1052-6234"],"eissn":["1095-7189"]},"date_created":"2026-02-05T13:33:05Z","department":[{"_id":"VlKo"},{"_id":"GradSch"}],"title":"Certifying solutions of degenerate semidefinite programs","_id":"21144"}]