[{"date_published":"2024-10-01T00:00:00Z","_id":"14542","quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2026-04-07T13:01:40Z","year":"2024","ddc":["510"],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"has_accepted_license":"1","month":"10","related_material":{"record":[{"relation":"dissertation_contains","id":"19540","status":"public"},{"id":"18135","relation":"dissertation_contains","status":"public"}]},"status":"public","corr_author":"1","arxiv":1,"volume":36,"title":"Universality in low-dimensional BCS theory","publication_status":"published","file":[{"file_id":"18786","creator":"dernst","date_updated":"2025-01-09T07:56:28Z","success":1,"file_name":"2024_ReviewsmathPhysics_Henheik.pdf","checksum":"2b053a4223b4db14b90520999ec56054","date_created":"2025-01-09T07:56:28Z","file_size":503910,"access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"publication":"Reviews in Mathematical Physics","abstract":[{"lang":"eng","text":"It is a remarkable property of BCS theory that the ratio of the energy gap at zero temperature Ξ\r\n and the critical temperature Tc is (approximately) given by a universal constant, independent of the microscopic details of the fermionic interaction. This universality has rigorously been proven quite recently in three spatial dimensions and three different limiting regimes: weak coupling, low density and high density. The goal of this short note is to extend the universal behavior to lower dimensions d=1,2 and give an exemplary proof in the weak coupling limit."}],"doi":"10.1142/s0129055x2360005x","publication_identifier":{"eissn":["1793-6659"],"issn":["0129-055X"]},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-11-15T23:48:14Z","article_type":"original","publisher":"World Scientific Publishing","intvolume":"        36","OA_place":"publisher","file_date_updated":"2025-01-09T07:56:28Z","day":"01","citation":{"short":"S.J. Henheik, A.B. Lauritsen, B. Roos, Reviews in Mathematical Physics 36 (2024).","ama":"Henheik SJ, Lauritsen AB, Roos B. Universality in low-dimensional BCS theory. <i>Reviews in Mathematical Physics</i>. 2024;36(9). doi:<a href=\"https://doi.org/10.1142/s0129055x2360005x\">10.1142/s0129055x2360005x</a>","chicago":"Henheik, Sven Joscha, Asbjørn Bækgaard Lauritsen, and Barbara Roos. “Universality in Low-Dimensional BCS Theory.” <i>Reviews in Mathematical Physics</i>. World Scientific Publishing, 2024. <a href=\"https://doi.org/10.1142/s0129055x2360005x\">https://doi.org/10.1142/s0129055x2360005x</a>.","mla":"Henheik, Sven Joscha, et al. “Universality in Low-Dimensional BCS Theory.” <i>Reviews in Mathematical Physics</i>, vol. 36, no. 9, 2360005, World Scientific Publishing, 2024, doi:<a href=\"https://doi.org/10.1142/s0129055x2360005x\">10.1142/s0129055x2360005x</a>.","apa":"Henheik, S. J., Lauritsen, A. B., &#38; Roos, B. (2024). Universality in low-dimensional BCS theory. <i>Reviews in Mathematical Physics</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/s0129055x2360005x\">https://doi.org/10.1142/s0129055x2360005x</a>","ista":"Henheik SJ, Lauritsen AB, Roos B. 2024. Universality in low-dimensional BCS theory. Reviews in Mathematical Physics. 36(9), 2360005.","ieee":"S. J. Henheik, A. B. Lauritsen, and B. Roos, “Universality in low-dimensional BCS theory,” <i>Reviews in Mathematical Physics</i>, vol. 36, no. 9. World Scientific Publishing, 2024."},"oa":1,"type":"journal_article","article_processing_charge":"Yes (in subscription journal)","ec_funded":1,"acknowledgement":"We thank Robert Seiringer for comments on the paper. J. H. gratefully acknowledges  partial  financial  support  by  the  ERC  Advanced  Grant  “RMTBeyond”No. 101020331.This research was funded in part by the Austrian Science Fund (FWF) grantnumber I6427.","department":[{"_id":"GradSch"},{"_id":"LaEr"},{"_id":"RoSe"}],"issue":"9","project":[{"grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020"},{"name":"Mathematical Challenges in BCS Theory of Superconductivity","_id":"bda63fe5-d553-11ed-ba76-a16e3d2f256b","grant_number":"I06427"}],"author":[{"full_name":"Henheik, Sven Joscha","last_name":"Henheik","first_name":"Sven Joscha","orcid":"0000-0003-1106-327X","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb"},{"full_name":"Lauritsen, Asbjørn Bækgaard","last_name":"Lauritsen","first_name":"Asbjørn Bækgaard","orcid":"0000-0003-4476-2288","id":"e1a2682f-dc8d-11ea-abe3-81da9ac728f1"},{"id":"5DA90512-D80F-11E9-8994-2E2EE6697425","first_name":"Barbara","orcid":"0000-0002-9071-5880","last_name":"Roos","full_name":"Roos, Barbara"}],"OA_type":"hybrid","isi":1,"external_id":{"arxiv":["2301.05621"],"isi":["001099640300002"]},"article_number":"2360005 ","scopus_import":"1"},{"ddc":["570"],"year":"2024","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"has_accepted_license":"1","month":"04","date_published":"2024-04-01T00:00:00Z","_id":"14543","quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2024-07-16T08:23:24Z","volume":147,"title":"Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders","status":"public","page":"1436-1456","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-11-16T12:36:51Z","article_type":"original","publisher":"Oxford University Press","publication_status":"published","abstract":[{"lang":"eng","text":"The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology. Utilizing exome sequencing and extensive international data sharing efforts, we identified 45 affected individuals from 28 unrelated families (consanguinity 93%) with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in ACBD6. We generated zebrafish and Xenopus tropicalis acbd6 knockouts by CRISPR/Cas9 and characterized the role of ACBD6 on protein N-myristoylation with YnMyr chemical proteomics in the model organisms and human cells, with the latter also being subjected further to ACBD6 peroxisomal localization studies. The affected individuals (23 males and 22 females), with ages ranging from 1 to 50 years old, typically present with a complex and progressive disease involving moderate-to-severe global developmental delay/intellectual disability (100%) with significant expressive language impairment (98%), movement disorders (97%), facial dysmorphism (95%), and mild cerebellar ataxia (85%) associated with gait impairment (94%), limb spasticity/hypertonia (76%), oculomotor (71%) and behavioural abnormalities (65%), overweight (59%), microcephaly (39%) and epilepsy (33%). The most conspicuous and common movement disorder was dystonia (94%), frequently leading to early-onset progressive postural deformities (97%), limb dystonia (55%), and cervical dystonia (31%). A jerky tremor in the upper limbs (63%), a mild head tremor (59%), parkinsonism/hypokinesia developing with advancing age (32%), and simple motor and vocal tics were among other frequent movement disorders. Midline brain malformations including corpus callosum abnormalities (70%), hypoplasia/agenesis of the anterior commissure (66%), short midbrain and small inferior cerebellar vermis (38% each), as well as hypertrophy of the clava (24%) were common neuroimaging findings. acbd6-deficient zebrafish and Xenopus models effectively recapitulated many clinical phenotypes reported in patients including movement disorders, progressive neuromotor impairment, seizures, microcephaly, craniofacial dysmorphism, and midbrain defects accompanied by developmental delay with increased mortality over time. Unlike ACBD5, ACBD6 did not show a peroxisomal localisation and ACBD6-deficiency was not associated with altered peroxisomal parameters in patient fibroblasts. Significant differences in YnMyr-labelling were observed for 68 co- and 18 post-translationally N-myristoylated proteins in patient-derived fibroblasts. N-Myristoylation was similarly affected in acbd6-deficient zebrafish and Xenopus tropicalis models, including Fus, Marcks, and Chchd-related proteins implicated in neurological diseases. The present study provides evidence that bi-allelic pathogenic variants in ACBD6 lead to a distinct neurodevelopmental syndrome accompanied by complex and progressive cognitive and movement disorders."}],"file":[{"file_id":"17254","creator":"dernst","date_updated":"2024-07-16T08:22:13Z","file_name":"2024_Brain_Kaiyrzhanov.pdf","success":1,"checksum":"0ee7a8ab9300225d60968f7a3e3cfa0d","date_created":"2024-07-16T08:22:13Z","file_size":2641456,"access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"publication":"Brain","extern":"1","doi":"10.1093/brain/awad380","pmid":1,"oa_version":"Submitted Version","publication_identifier":{"eissn":["1460-2156"],"issn":["0006-8950"]},"issue":"4","department":[{"_id":"GradSch"}],"author":[{"first_name":"Rauan","full_name":"Kaiyrzhanov, Rauan","last_name":"Kaiyrzhanov"},{"last_name":"Rad","full_name":"Rad, Aboulfazl","first_name":"Aboulfazl"},{"last_name":"Lin","full_name":"Lin, Sheng-Jia","first_name":"Sheng-Jia"},{"full_name":"Bertoli-Avella, Aida","last_name":"Bertoli-Avella","first_name":"Aida"},{"full_name":"Kallemeijn, Wouter W","last_name":"Kallemeijn","first_name":"Wouter W"},{"full_name":"Godwin, Annie","last_name":"Godwin","first_name":"Annie"},{"first_name":"Maha S","last_name":"Zaki","full_name":"Zaki, Maha S"},{"orcid":"0000-0002-2512-7812","id":"3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3","first_name":"Kevin","last_name":"Huang","full_name":"Huang, Kevin"},{"last_name":"Lau","full_name":"Lau, Tracy","first_name":"Tracy"},{"first_name":"Cassidy","full_name":"Petree, Cassidy","last_name":"Petree"},{"full_name":"Efthymiou, Stephanie","last_name":"Efthymiou","first_name":"Stephanie"},{"last_name":"Ghayoor Karimiani","full_name":"Ghayoor Karimiani, Ehsan","first_name":"Ehsan"},{"first_name":"Maja","full_name":"Hempel, Maja","last_name":"Hempel"},{"first_name":"Elizabeth A","full_name":"Normand, Elizabeth A","last_name":"Normand"},{"first_name":"Sabine","last_name":"Rudnik-Schöneborn","full_name":"Rudnik-Schöneborn, Sabine"},{"first_name":"Ulrich A","last_name":"Schatz","full_name":"Schatz, Ulrich A"},{"full_name":"Baggelaar, Marc P","last_name":"Baggelaar","first_name":"Marc P"},{"full_name":"Ilyas, Muhammad","last_name":"Ilyas","first_name":"Muhammad"},{"first_name":"Tipu","full_name":"Sultan, Tipu","last_name":"Sultan"},{"full_name":"Alvi, Javeria Raza","last_name":"Alvi","first_name":"Javeria Raza"},{"first_name":"Manizha","full_name":"Ganieva, Manizha","last_name":"Ganieva"},{"first_name":"Ben","full_name":"Fowler, Ben","last_name":"Fowler"},{"first_name":"Ruxandra","full_name":"Aanicai, Ruxandra","last_name":"Aanicai"},{"last_name":"Akay Tayfun","full_name":"Akay Tayfun, Gulsen","first_name":"Gulsen"},{"last_name":"Al Saman","full_name":"Al Saman, Abdulaziz","first_name":"Abdulaziz"},{"full_name":"Alswaid, Abdulrahman","last_name":"Alswaid","first_name":"Abdulrahman"},{"full_name":"Amiri, Nafise","last_name":"Amiri","first_name":"Nafise"},{"full_name":"Asilova, Nilufar","last_name":"Asilova","first_name":"Nilufar"},{"full_name":"Shotelersuk, Vorasuk","last_name":"Shotelersuk","first_name":"Vorasuk"},{"first_name":"Patra","last_name":"Yeetong","full_name":"Yeetong, Patra"},{"first_name":"Matloob","last_name":"Azam","full_name":"Azam, Matloob"},{"full_name":"Babaei, Meisam","last_name":"Babaei","first_name":"Meisam"},{"full_name":"Bahrami Monajemi, Gholamreza","last_name":"Bahrami Monajemi","first_name":"Gholamreza"},{"first_name":"Pouria","full_name":"Mohammadi, Pouria","last_name":"Mohammadi"},{"full_name":"Samie, Saeed","last_name":"Samie","first_name":"Saeed"},{"last_name":"Banu","full_name":"Banu, Selina Husna","first_name":"Selina Husna"},{"last_name":"Basto","full_name":"Basto, Jorge Pinto","first_name":"Jorge Pinto"},{"first_name":"Fanny","full_name":"Kortüm, Fanny","last_name":"Kortüm"},{"last_name":"Bauer","full_name":"Bauer, Mislen","first_name":"Mislen"},{"first_name":"Peter","last_name":"Bauer","full_name":"Bauer, Peter"},{"full_name":"Beetz, Christian","last_name":"Beetz","first_name":"Christian"},{"first_name":"Masoud","last_name":"Garshasbi","full_name":"Garshasbi, Masoud"},{"first_name":"Awatif","last_name":"Hameed Issa","full_name":"Hameed Issa, Awatif"},{"full_name":"Eyaid, Wafaa","last_name":"Eyaid","first_name":"Wafaa"},{"full_name":"Ahmed, Hind","last_name":"Ahmed","first_name":"Hind"},{"last_name":"Hashemi","full_name":"Hashemi, Narges","first_name":"Narges"},{"first_name":"Kazem","last_name":"Hassanpour","full_name":"Hassanpour, Kazem"},{"full_name":"Herman, Isabella","last_name":"Herman","first_name":"Isabella"},{"first_name":"Sherozjon","last_name":"Ibrohimov","full_name":"Ibrohimov, Sherozjon"},{"first_name":"Ban A","full_name":"Abdul-Majeed, Ban A","last_name":"Abdul-Majeed"},{"first_name":"Maria","last_name":"Imdad","full_name":"Imdad, Maria"},{"full_name":"Isrofilov, Maksudjon","last_name":"Isrofilov","first_name":"Maksudjon"},{"first_name":"Qassem","last_name":"Kaiyal","full_name":"Kaiyal, Qassem"},{"first_name":"Suliman","last_name":"Khan","full_name":"Khan, Suliman"},{"first_name":"Brian","last_name":"Kirmse","full_name":"Kirmse, Brian"},{"last_name":"Koster","full_name":"Koster, Janet","first_name":"Janet"},{"full_name":"Lourenço, Charles Marques","last_name":"Lourenço","first_name":"Charles Marques"},{"first_name":"Tadahiro","full_name":"Mitani, Tadahiro","last_name":"Mitani"},{"first_name":"Oana","full_name":"Moldovan, Oana","last_name":"Moldovan"},{"first_name":"David","last_name":"Murphy","full_name":"Murphy, David"},{"first_name":"Maryam","last_name":"Najafi","full_name":"Najafi, Maryam"},{"last_name":"Pehlivan","full_name":"Pehlivan, Davut","first_name":"Davut"},{"full_name":"Rocha, Maria Eugenia","last_name":"Rocha","first_name":"Maria Eugenia"},{"full_name":"Salpietro, Vincenzo","last_name":"Salpietro","first_name":"Vincenzo"},{"full_name":"Schmidts, Miriam","last_name":"Schmidts","first_name":"Miriam"},{"first_name":"Adel","full_name":"Shalata, Adel","last_name":"Shalata"},{"first_name":"Mohammad","full_name":"Mahroum, Mohammad","last_name":"Mahroum"},{"first_name":"Jawabreh Kassem","full_name":"Talbeya, Jawabreh Kassem","last_name":"Talbeya"},{"first_name":"Robert W","full_name":"Taylor, Robert W","last_name":"Taylor"},{"last_name":"Vazquez","full_name":"Vazquez, Dayana","first_name":"Dayana"},{"first_name":"Annalisa","last_name":"Vetro","full_name":"Vetro, Annalisa"},{"first_name":"Hans R","last_name":"Waterham","full_name":"Waterham, Hans R"},{"first_name":"Mashaya","full_name":"Zaman, Mashaya","last_name":"Zaman"},{"full_name":"Schrader, Tina A","last_name":"Schrader","first_name":"Tina A"},{"first_name":"Wendy K","last_name":"Chung","full_name":"Chung, Wendy K"},{"first_name":"Renzo","full_name":"Guerrini, Renzo","last_name":"Guerrini"},{"first_name":"James R","last_name":"Lupski","full_name":"Lupski, James R"},{"first_name":"Joseph","last_name":"Gleeson","full_name":"Gleeson, Joseph"},{"first_name":"Mohnish","last_name":"Suri","full_name":"Suri, Mohnish"},{"first_name":"Yalda","full_name":"Jamshidi, Yalda","last_name":"Jamshidi"},{"first_name":"Kailash P","last_name":"Bhatia","full_name":"Bhatia, Kailash P"},{"full_name":"Vona, Barbara","last_name":"Vona","first_name":"Barbara"},{"full_name":"Schrader, Michael","last_name":"Schrader","first_name":"Michael"},{"first_name":"Mariasavina","last_name":"Severino","full_name":"Severino, Mariasavina"},{"first_name":"Matthew","last_name":"Guille","full_name":"Guille, Matthew"},{"last_name":"Tate","full_name":"Tate, Edward W","first_name":"Edward W"},{"last_name":"Varshney","full_name":"Varshney, Gaurav K","first_name":"Gaurav K"},{"first_name":"Henry","last_name":"Houlden","full_name":"Houlden, Henry"},{"first_name":"Reza","last_name":"Maroofian","full_name":"Maroofian, Reza"}],"external_id":{"pmid":["37951597"]},"scopus_import":"1","intvolume":"       147","keyword":["Neurology (clinical)"],"file_date_updated":"2024-07-16T08:22:13Z","day":"01","citation":{"ieee":"R. Kaiyrzhanov <i>et al.</i>, “Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders,” <i>Brain</i>, vol. 147, no. 4. Oxford University Press, pp. 1436–1456, 2024.","apa":"Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., … Maroofian, R. (2024). Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. <i>Brain</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/brain/awad380\">https://doi.org/10.1093/brain/awad380</a>","ista":"Kaiyrzhanov R, Rad A, Lin S-J, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun G, Al Saman A, Alswaid A, Amiri N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Bahrami Monajemi G, Mohammadi P, Samie S, Banu SH, Basto JP, Kortüm F, Bauer M, Bauer P, Beetz C, Garshasbi M, Hameed Issa A, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D, Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW, Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M, Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R. 2024. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. 147(4), 1436–1456.","mla":"Kaiyrzhanov, Rauan, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” <i>Brain</i>, vol. 147, no. 4, Oxford University Press, 2024, pp. 1436–56, doi:<a href=\"https://doi.org/10.1093/brain/awad380\">10.1093/brain/awad380</a>.","chicago":"Kaiyrzhanov, Rauan, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella, Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” <i>Brain</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/brain/awad380\">https://doi.org/10.1093/brain/awad380</a>.","short":"R. Kaiyrzhanov, A. Rad, S.-J. Lin, A. Bertoli-Avella, W.W. Kallemeijn, A. Godwin, M.S. Zaki, K. Huang, T. Lau, C. Petree, S. Efthymiou, E. Ghayoor Karimiani, M. Hempel, E.A. Normand, S. Rudnik-Schöneborn, U.A. Schatz, M.P. Baggelaar, M. Ilyas, T. Sultan, J.R. Alvi, M. Ganieva, B. Fowler, R. Aanicai, G. Akay Tayfun, A. Al Saman, A. Alswaid, N. Amiri, N. Asilova, V. Shotelersuk, P. Yeetong, M. Azam, M. Babaei, G. Bahrami Monajemi, P. Mohammadi, S. Samie, S.H. Banu, J.P. Basto, F. Kortüm, M. Bauer, P. Bauer, C. Beetz, M. Garshasbi, A. Hameed Issa, W. Eyaid, H. Ahmed, N. Hashemi, K. Hassanpour, I. Herman, S. Ibrohimov, B.A. Abdul-Majeed, M. Imdad, M. Isrofilov, Q. Kaiyal, S. Khan, B. Kirmse, J. Koster, C.M. Lourenço, T. Mitani, O. Moldovan, D. Murphy, M. Najafi, D. Pehlivan, M.E. Rocha, V. Salpietro, M. Schmidts, A. Shalata, M. Mahroum, J.K. Talbeya, R.W. Taylor, D. Vazquez, A. Vetro, H.R. Waterham, M. Zaman, T.A. Schrader, W.K. Chung, R. Guerrini, J.R. Lupski, J. Gleeson, M. Suri, Y. Jamshidi, K.P. Bhatia, B. Vona, M. Schrader, M. Severino, M. Guille, E.W. Tate, G.K. Varshney, H. Houlden, R. Maroofian, Brain 147 (2024) 1436–1456.","ama":"Kaiyrzhanov R, Rad A, Lin S-J, et al. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. <i>Brain</i>. 2024;147(4):1436-1456. doi:<a href=\"https://doi.org/10.1093/brain/awad380\">10.1093/brain/awad380</a>"},"oa":1,"article_processing_charge":"No","type":"journal_article"},{"title":"Advanced motion tracking for interactive mass spectrometry imaging (IMSI)","volume":495,"status":"public","month":"01","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"has_accepted_license":"1","year":"2024","ddc":["540"],"language":[{"iso":"eng"}],"date_updated":"2025-09-04T11:30:59Z","quality_controlled":"1","_id":"14653","date_published":"2024-01-01T00:00:00Z","article_number":"117168","scopus_import":"1","isi":1,"external_id":{"isi":["001125054400001"]},"author":[{"full_name":"Kluibenschedl, Florian","last_name":"Kluibenschedl","first_name":"Florian","id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9"},{"full_name":"Ploner, Anna","last_name":"Ploner","first_name":"Anna"},{"full_name":"Meisenbichler, Christina","last_name":"Meisenbichler","first_name":"Christina"},{"first_name":"Robert","last_name":"Konrat","full_name":"Konrat, Robert"},{"first_name":"Thomas","full_name":"Müller, Thomas","last_name":"Müller"}],"acknowledgement":"We would like to thank Marco Sealey Cardona, PhD for help with the mouse brain samples and acknowledge the financial support by 1669 Förderkreis of the University of Innsbruck, Austria Wirtschaftsservice (AWS), D. Swarovski KG and Tyrolean Science Fund (TWF).","department":[{"_id":"GradSch"}],"type":"journal_article","article_processing_charge":"Yes (in subscription journal)","oa":1,"citation":{"ieee":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, and T. Müller, “Advanced motion tracking for interactive mass spectrometry imaging (IMSI),” <i>International Journal of Mass Spectrometry</i>, vol. 495. Elsevier, 2024.","ista":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. 2024. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). International Journal of Mass Spectrometry. 495, 117168.","apa":"Kluibenschedl, F., Ploner, A., Meisenbichler, C., Konrat, R., &#38; Müller, T. (2024). Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>","mla":"Kluibenschedl, Florian, et al. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>, vol. 495, 117168, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>.","chicago":"Kluibenschedl, Florian, Anna Ploner, Christina Meisenbichler, Robert Konrat, and Thomas Müller. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>.","short":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, T. Müller, International Journal of Mass Spectrometry 495 (2024).","ama":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. 2024;495. doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>"},"day":"01","file_date_updated":"2024-07-16T08:27:34Z","intvolume":"       495","article_type":"original","publisher":"Elsevier","date_created":"2023-12-10T23:00:57Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"issn":["1387-3806"]},"oa_version":"Published Version","doi":"10.1016/j.ijms.2023.117168","abstract":[{"text":"Mass spectrometry imaging (MSI) is a powerful analytical technique for the two-dimensional (2D) localization of chemicals on surfaces. Conventional MSI experiments require to predefine the surface of interest based on photographic or microscopic images. Typically, these boundaries can no longer be changed or adjusted once the experiment has been started. In terms of a more interactive approach we recently developed a pen-like ionization interface which is directly connected to the mass spectrometer. The device allows the user to ionize chemicals by desorption electrospray ionization (DESI) and to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging experiment: interactive mass spectrometry imaging (IMSI). For this application, we present a novel approach for a robust, optical flow-based motion detection. While the live video stream from the camera is used to track the pen's motion across the surface a post-acquisition algorithm correlates the coordinates of the pen trajectory with respective mass spectra obtained from a simultaneous mass spectrometric data acquisition. This algorithm is no longer dependent on a single, manually applied optical marker on the sample surface, which has to be visible on all video frames throughout the analysis. The advanced DESI-IMSI method was successfully tested on inkjet-printed letters as well as mouse brain tissue samples. Validation of the results was done by comparing DESI-IMSI with standard DESI-MSI data.","lang":"eng"}],"file":[{"file_size":3003139,"date_created":"2024-07-16T08:27:34Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","creator":"dernst","file_id":"17256","date_updated":"2024-07-16T08:27:34Z","checksum":"6c5eb6dc07af70a59251d2c6fed38894","file_name":"2024_IJMS_Kluibenschedl.pdf","success":1}],"publication":"International Journal of Mass Spectrometry","publication_status":"published"},{"volume":63,"title":"To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries","corr_author":"1","status":"public","month":"07","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"20607"}]},"year":"2024","ddc":["540"],"quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2026-04-07T12:27:23Z","_id":"14687","date_published":"2024-07-08T00:00:00Z","author":[{"full_name":"Jethwa, Rajesh B","last_name":"Jethwa","first_name":"Rajesh B","orcid":"0000-0002-0404-4356","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f"},{"full_name":"Mondal, Soumyadip","last_name":"Mondal","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","first_name":"Soumyadip"},{"full_name":"Pant, Bhargavi","last_name":"Pant","first_name":"Bhargavi","id":"50c64d4d-eb97-11eb-a6c2-d33e5e14f112"},{"last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander"}],"scopus_import":"1","article_number":"e202316476","external_id":{"pmid":["38095355"],"isi":["001241932700001"]},"isi":1,"ec_funded":1,"project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"}],"issue":"28","department":[{"_id":"StFr"},{"_id":"GradSch"}],"acknowledgement":"S.A.F. is indebted to ISTA for support. R.B.J. thanks the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413 for funding. B.P. thanks Alistore ERI for providing a PhD scholarship.","citation":{"ista":"Jethwa RB, Mondal S, Pant B, Freunberger SA. 2024. To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. Angewandte Chemie International Edition. 63(28), e202316476.","apa":"Jethwa, R. B., Mondal, S., Pant, B., &#38; Freunberger, S. A. (2024). To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202316476\">https://doi.org/10.1002/anie.202316476</a>","mla":"Jethwa, Rajesh B., et al. “To DISP or Not? The Far‐reaching Reaction Mechanisms Underpinning Lithium‐air Batteries.” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 28, e202316476, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/anie.202316476\">10.1002/anie.202316476</a>.","ieee":"R. B. Jethwa, S. Mondal, B. Pant, and S. A. Freunberger, “To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries,” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 28. Wiley, 2024.","short":"R.B. Jethwa, S. Mondal, B. Pant, S.A. Freunberger, Angewandte Chemie International Edition 63 (2024).","ama":"Jethwa RB, Mondal S, Pant B, Freunberger SA. To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries. <i>Angewandte Chemie International Edition</i>. 2024;63(28). doi:<a href=\"https://doi.org/10.1002/anie.202316476\">10.1002/anie.202316476</a>","chicago":"Jethwa, Rajesh B, Soumyadip Mondal, Bhargavi Pant, and Stefan Alexander Freunberger. “To DISP or Not? The Far‐reaching Reaction Mechanisms Underpinning Lithium‐air Batteries.” <i>Angewandte Chemie International Edition</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/anie.202316476\">https://doi.org/10.1002/anie.202316476</a>."},"type":"journal_article","article_processing_charge":"Yes (via OA deal)","oa":1,"intvolume":"        63","day":"08","file_date_updated":"2024-07-16T11:54:46Z","keyword":["General Chemistry","Catalysis"],"date_created":"2023-12-15T16:10:13Z","publisher":"Wiley","article_type":"review","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Published Version","pmid":1,"publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"publication":"Angewandte Chemie International Edition","file":[{"file_size":4766445,"date_created":"2024-07-16T11:54:46Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","checksum":"fe2c23454279eb9d76ed6ca9970c21c7","file_name":"2024_AngChemieInt_Jethwa.pdf","success":1,"creator":"dernst","file_id":"17261","date_updated":"2024-07-16T11:54:46Z"}],"abstract":[{"lang":"eng","text":"The short history of research on Li-O2 batteries has seen a remarkable number of mechanistic U-turns over the years. From the initial use of carbonate electrolytes, that were then found to be entirely unsuitable, to the belief that (su)peroxide was solely responsible for degradation, before the more reactive singlet oxygen was found to form, to the hypothesis that capacity depends on a competing surface/solution mechanism before a practically exclusive solution mechanism was identified. Herein, we argue for an ever-fresh look at the reported data without bias towards supposedly established explanations. We explain how the latest findings on rate and capacity limits, as well as the origin of side reactions, are connected via the disproportionation (DISP) step in the (dis)charge mechanism. Therefrom, directions emerge for the design of electrolytes and mediators on how to suppress side reactions and to enable high rate and high reversible capacity."}],"publication_status":"published","doi":"10.1002/anie.202316476"},{"publisher":"Springer Nature","article_type":"original","date_created":"2023-12-21T10:14:37Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","publication_identifier":{"issn":["1615-3375"],"eissn":["1615-3383"]},"doi":"10.1007/s10208-024-09686-3","abstract":[{"text":"We present a discretization of the dynamic optimal transport problem for which we can obtain the convergence rate for the value of the transport cost to its continuous value when the temporal and spatial stepsize vanish. This convergence result does not require any regularity assumption on the measures, though experiments suggest that the rate is not sharp. Via an analysis of the duality gap we also obtain the convergence rates for the gradient of the optimal potentials and the velocity field under mild regularity assumptions. To obtain such rates we discretize the dual formulation of the dynamic optimal transport problem and use the mature literature related to the error due to discretizing the Hamilton-Jacobi equation.","lang":"eng"}],"publication":"Foundations of Computational Mathematics","publication_status":"epub_ahead","scopus_import":"1","isi":1,"external_id":{"isi":["001352503300001"],"arxiv":["2312.12213"]},"OA_type":"hybrid","author":[{"full_name":"Ishida, Sadashige","last_name":"Ishida","orcid":"0000-0002-3121-3100","id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","first_name":"Sadashige"},{"first_name":"Hugo","last_name":"Lavenant","full_name":"Lavenant, Hugo"}],"project":[{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088","grant_number":"101045083"}],"department":[{"_id":"GradSch"},{"_id":"ChWo"}],"acknowledgement":"The authors would like to thank Chris Wojtan for his continuous support and several interesting discussions. Part of this research was performed during two visits: one of SI to the BIDSA research center at Bocconi University, and one of HL to the Institute of Science and Technology Austria. Both host institutions are warmly acknowledged for the hospitality. HL is partially supported by the MUR-Prin 2022-202244A7YL “Gradient Flows and Non-Smooth Geometric Structures with Applications to Optimization and Machine Learning”, funded by the European Union - Next Generation EU. SI is supported in part by ERC Consolidator Grant 101045083 “CoDiNA” funded by the European Research Council.","type":"journal_article","article_processing_charge":"Yes (via OA deal)","oa":1,"citation":{"ieee":"S. Ishida and H. Lavenant, “Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation,” <i>Foundations of Computational Mathematics</i>. Springer Nature, 2024.","ista":"Ishida S, Lavenant H. 2024. Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. Foundations of Computational Mathematics.","apa":"Ishida, S., &#38; Lavenant, H. (2024). Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. <i>Foundations of Computational Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10208-024-09686-3\">https://doi.org/10.1007/s10208-024-09686-3</a>","mla":"Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization of Dynamic Optimal Transport Using the Dual Formulation.” <i>Foundations of Computational Mathematics</i>, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s10208-024-09686-3\">10.1007/s10208-024-09686-3</a>.","chicago":"Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization of Dynamic Optimal Transport Using the Dual Formulation.” <i>Foundations of Computational Mathematics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10208-024-09686-3\">https://doi.org/10.1007/s10208-024-09686-3</a>.","short":"S. Ishida, H. Lavenant, Foundations of Computational Mathematics (2024).","ama":"Ishida S, Lavenant H. Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. <i>Foundations of Computational Mathematics</i>. 2024. doi:<a href=\"https://doi.org/10.1007/s10208-024-09686-3\">10.1007/s10208-024-09686-3</a>"},"day":"11","OA_place":"publisher","keyword":["Optimal transport","Hamilton-Jacobi equation","convex optimization"],"month":"11","year":"2024","ddc":["000"],"date_updated":"2026-06-18T17:37:10Z","language":[{"iso":"eng"}],"quality_controlled":"1","_id":"14703","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s10208-024-09686-3"}],"date_published":"2024-11-11T00:00:00Z","title":"Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation","corr_author":"1","arxiv":1,"status":"public"},{"_id":"14705","file":[{"date_updated":"2023-12-22T13:54:21Z","file_id":"14707","creator":"melkrewi","file_name":"readme.txt.txt","success":1,"checksum":"bdaf1392867786634ec5466d528c36ca","access_level":"open_access","relation":"main_file","content_type":"text/plain","date_created":"2023-12-22T13:54:21Z","file_size":847},{"content_type":"application/x-zip-compressed","relation":"main_file","access_level":"open_access","file_size":343632753,"date_created":"2023-12-22T14:14:06Z","date_updated":"2023-12-22T14:14:06Z","creator":"melkrewi","file_id":"14708","checksum":"973e1cbdab923a71709782177980829f","file_name":"data_artemia_franciscana_genome.zip","success":1}],"abstract":[{"text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, are still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of Artemia franciscana (Kellogg 1906), from the Great Salt Lake, USA. The genome is 1GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species.","lang":"eng"}],"date_published":"2024-01-02T00:00:00Z","doi":"10.15479/AT:ISTA:14705","oa_version":"Published Version","date_updated":"2025-09-04T12:05:42Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","contributor":[{"contributor_type":"researcher","last_name":"Bett","id":"57854184-AAE0-11E9-8D04-98D6E5697425","first_name":"Vincent K"},{"first_name":"Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member","last_name":"Macon"},{"last_name":"Vicoso","contributor_type":"supervisor","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306"},{"contributor_type":"researcher","last_name":"Elkrewi","orcid":"0000-0002-5328-7231","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N"}],"year":"2024","ddc":["576"],"month":"01","date_created":"2023-12-22T13:40:48Z","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","related_material":{"record":[{"relation":"used_in_publication","id":"15009","status":"public"}]},"status":"public","day":"02","file_date_updated":"2023-12-22T14:14:06Z","keyword":["sex chromosome evolution","genome assembly","dosage compensation"],"corr_author":"1","citation":{"mla":"Elkrewi, Marwan N. <i>Data from “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.”</i> Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>.","ista":"Elkrewi MN. 2024. Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>.","apa":"Elkrewi, M. N. (2024). Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>","ieee":"M. N. Elkrewi, “Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.’” Institute of Science and Technology Austria, 2024.","short":"M.N. Elkrewi, (2024).","ama":"Elkrewi MN. Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>","chicago":"Elkrewi, Marwan N. “Data from ‘Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.’” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>."},"article_processing_charge":"No","type":"research_data","oa":1,"project":[{"_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","name":"The highjacking of meiosis for asexual reproduction","grant_number":"F8810"}],"department":[{"_id":"GradSch"},{"_id":"BeVi"}],"author":[{"full_name":"Elkrewi, Marwan N","last_name":"Elkrewi","first_name":"Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","orcid":"0000-0002-5328-7231"}],"title":"Data from \"Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation\""},{"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","title":"Local adaptation, genetic load and extinction in metapopulations","page":"183","corr_author":"1","supervisor":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H"},{"full_name":"Polechova, Jitka","last_name":"Polechova","first_name":"Jitka"},{"first_name":"Himani","full_name":"Sachdeva, Himani","last_name":"Sachdeva"}],"acknowledged_ssus":[{"_id":"SSU"}],"status":"public","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"month":"01","related_material":{"record":[{"status":"public","id":"10787","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"10658"},{"status":"public","relation":"part_of_dissertation","id":"14732"}]},"year":"2024","ddc":["576"],"language":[{"iso":"eng"}],"date_updated":"2026-04-07T12:54:29Z","date_published":"2024-01-19T00:00:00Z","_id":"14711","alternative_title":["ISTA Thesis"],"author":[{"full_name":"Olusanya, Oluwafunmilola O","last_name":"Olusanya","first_name":"Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1971-8314"}],"ec_funded":1,"department":[{"_id":"NiBa"},{"_id":"GradSch"}],"project":[{"grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"P32896","name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"},{"grant_number":"26380","name":"Polygenic Adaptation in a Metapopulation","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6"}],"citation":{"short":"O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations, Institute of Science and Technology Austria, 2024.","ama":"Olusanya OO. Local adaptation, genetic load and extinction in metapopulations. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>","chicago":"Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction in Metapopulations.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>.","mla":"Olusanya, Oluwafunmilola O. <i>Local Adaptation, Genetic Load and Extinction in Metapopulations</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>.","ista":"Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations. Institute of Science and Technology Austria.","apa":"Olusanya, O. O. (2024). <i>Local adaptation, genetic load and extinction in metapopulations</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>","ieee":"O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,” Institute of Science and Technology Austria, 2024."},"oa":1,"type":"dissertation","article_processing_charge":"No","OA_place":"publisher","file_date_updated":"2024-01-03T18:31:34Z","day":"19","date_created":"2023-12-26T22:49:53Z","publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa_version":"Published Version","publication_identifier":{"issn":["2663-337X"]},"publication_status":"published","file":[{"creator":"oolusany","file_id":"14730","date_updated":"2024-01-03T18:30:13Z","checksum":"de179b1c6758f182ff0c70d8b38c1501","file_name":"FinalSubmission_Thesis_OLUSANYA.zip","file_size":16986244,"date_created":"2024-01-03T18:30:13Z","relation":"source_file","content_type":"application/zip","access_level":"closed"},{"success":1,"file_name":"FinalSubmission2_Thesis_OLUSANYA.pdf","checksum":"0e331585e3cd4823320aab4e69e64ccf","date_updated":"2024-01-03T18:31:34Z","file_id":"14731","creator":"oolusany","access_level":"open_access","content_type":"application/pdf","relation":"main_file","date_created":"2024-01-03T18:31:34Z","file_size":6460403}],"abstract":[{"lang":"eng","text":"In nature, different species find their niche in a range of environments, each with its unique characteristics. While some thrive in uniform (homogeneous) landscapes where environmental conditions stay relatively consistent across space, others traverse the complexities of spatially heterogeneous terrains. Comprehending how species are distributed and how they interact within these landscapes holds the key to gaining insights into their evolutionary dynamics while also informing conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous landscapes, when the rate of dispersal is low compared to spatial fluctuations in selection pressure, localized adaptations may emerge. Such adaptation in response to varying selection strengths plays an important role in the persistence of populations in our rapidly changing world. Hence, species in nature are continuously in a struggle to adapt to local environmental conditions, to ensure their continued survival. Natural populations can often adapt in time scales short enough for evolutionary changes to influence ecological dynamics and vice versa, thereby creating a feedback between evolution and demography. The analysis of this feedback and the relative contributions of gene flow, demography, drift, and natural selection to genetic variation and differentiation has remained a recurring theme in evolutionary biology. Nevertheless, the effective role of these forces in maintaining variation and shaping patterns of diversity is not fully understood. Even in homogeneous environments devoid of local adaptations, such understanding remains elusive. Understanding this feedback is crucial, for example in determining the conditions under which extinction risk can be mitigated in peripheral populations subject to deleterious mutation accumulation at the edges of species’ ranges\r\nas well as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform and spatially heterogeneous metapopulations, investigating and providing theoretical insights into the dynamics of local adaptation in the latter and examining the dynamics of load and extinction as well as the impact of joint ecological and evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject matter, clarifying concepts and ideas used throughout the thesis. In chapter 2, we explore how fast a species distributed across a heterogeneous landscape adapts to changing conditions marked by alterations in carrying capacity, selection pressure, and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection and drift influences adaptation and the maintenance of variation in a metapopulation with three habitats, an extension of previous models of adaptation in two habitats. We further develop analytical approximations for the critical threshold required for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on understanding the interplay between ecology and evolution as coupled processes. We investigate how eco-evolutionary feedback between migration, selection, drift, and demography influences eco-evolutionary outcomes in marginal populations subject to deleterious mutation accumulation. Using simulations as well as theoretical approximations of the coupled dynamics of population size and allele frequency, we analyze how gene flow from a large mainland source influences genetic load and population size on an island (i.e., in a marginal population) under genetically realistic assumptions. Analyses of this sort are important because small isolated populations, are repeatedly affected by complex interactions between ecological and evolutionary processes, which can lead to their death. Understanding these interactions can therefore provide an insight into the conditions under which extinction risk can be mitigated in peripheral populations thus, contributing to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation) and extinction risk in a metapopulation. We explore the role of gene flow, selection, and dominance on load and extinction risk and further pinpoint critical thresholds required for metapopulation persistence.\r\n\r\nOverall this research contributes to our understanding of ecological and evolutionary mechanisms that shape species’ persistence in fragmented landscapes, a crucial foundation for successful conservation efforts and biodiversity management."}],"doi":"10.15479/at:ista:14711","degree_awarded":"PhD"},{"arxiv":1,"corr_author":"1","page":"9853-9871","status":"public","volume":527,"title":"Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape","quality_controlled":"1","date_updated":"2025-09-04T11:51:50Z","language":[{"iso":"eng"}],"_id":"14852","date_published":"2024-02-01T00:00:00Z","month":"02","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"year":"2024","ddc":["520"],"citation":{"mla":"Kramarenko, Ivan, et al. “Linking UV Spectral Properties of MUSE Ly α Emitters at <i>z</i> ≳ 3 to Lyman Continuum Escape.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 527, no. 4, Oxford University Press, 2024, pp. 9853–71, doi:<a href=\"https://doi.org/10.1093/mnras/stad3853\">10.1093/mnras/stad3853</a>.","ista":"Kramarenko I, Kerutt J, Verhamme A, Oesch PA, Barrufet L, Matthee JJ, Kusakabe H, Goovaerts I, Thai TT. 2024. Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. Monthly Notices of the Royal Astronomical Society. 527(4), 9853–9871.","apa":"Kramarenko, I., Kerutt, J., Verhamme, A., Oesch, P. A., Barrufet, L., Matthee, J. J., … Thai, T. T. (2024). Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stad3853\">https://doi.org/10.1093/mnras/stad3853</a>","ieee":"I. Kramarenko <i>et al.</i>, “Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 527, no. 4. Oxford University Press, pp. 9853–9871, 2024.","short":"I. Kramarenko, J. Kerutt, A. Verhamme, P.A. Oesch, L. Barrufet, J.J. Matthee, H. Kusakabe, I. Goovaerts, T.T. Thai, Monthly Notices of the Royal Astronomical Society 527 (2024) 9853–9871.","ama":"Kramarenko I, Kerutt J, Verhamme A, et al. Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. <i>Monthly Notices of the Royal Astronomical Society</i>. 2024;527(4):9853-9871. doi:<a href=\"https://doi.org/10.1093/mnras/stad3853\">10.1093/mnras/stad3853</a>","chicago":"Kramarenko, Ivan, J Kerutt, A Verhamme, P A Oesch, L Barrufet, Jorryt J Matthee, H Kusakabe, I Goovaerts, and T T Thai. “Linking UV Spectral Properties of MUSE Ly α Emitters at <i>z</i> ≳ 3 to Lyman Continuum Escape.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/mnras/stad3853\">https://doi.org/10.1093/mnras/stad3853</a>."},"article_processing_charge":"Yes","type":"journal_article","oa":1,"intvolume":"       527","day":"01","file_date_updated":"2024-01-23T12:30:45Z","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"author":[{"orcid":"0000-0001-5346-6048","first_name":"Ivan","id":"9a9394cb-3200-11ee-973b-f5ba2a8b16e4","full_name":"Kramarenko, Ivan","last_name":"Kramarenko"},{"first_name":"J","last_name":"Kerutt","full_name":"Kerutt, J"},{"full_name":"Verhamme, A","last_name":"Verhamme","first_name":"A"},{"first_name":"P A","last_name":"Oesch","full_name":"Oesch, P A"},{"last_name":"Barrufet","full_name":"Barrufet, L","first_name":"L"},{"orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","last_name":"Matthee"},{"first_name":"H","last_name":"Kusakabe","full_name":"Kusakabe, H"},{"first_name":"I","last_name":"Goovaerts","full_name":"Goovaerts, I"},{"full_name":"Thai, T T","last_name":"Thai","first_name":"T T"}],"scopus_import":"1","isi":1,"external_id":{"arxiv":["2305.07044"],"isi":["001133672400004"]},"issue":"4","department":[{"_id":"GradSch"},{"_id":"JoMa"}],"acknowledgement":"We thank the anonymous referee for the constructive feedback that helped to improve the manuscript. We thank Michael Maseda, Daniel Schaerer, Charlotte Simmonds, and Rashmi Gottumukkala for useful comments and productive discussions. We also thank the organizers and participants of the 24th MUSE Science Busy Week in Leiden. IGK acknowledges an Excellence Master Fellowship granted by the Faculty of Science of the University of Geneva. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant number 200020_207349 and SNSF Professorship grant number 190079. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant number 140. This paper is based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 094.A-0289(B), 095.A-0010(A), 096.A-0045(A), 096.A-0045(B), 094.A-0205, 095.A-0240, 096.A-0090, 097.A-0160, and 098.A-0017. We made extensive use of several open-source software packages and we are thankful to the respective authors for sharing their work: NUMPY (Harris et al. 2020), ASTROPY (Astropy Collaboration 2022), MATPLOTLIB (Hunter 2007), IPYTHON (Perez & Granger 2007), and TOPCAT (Taylor 2005).","oa_version":"Published Version","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"abstract":[{"lang":"eng","text":"The physical conditions giving rise to high escape fractions of ionizing radiation (LyC fesc) in star-forming galaxies – most likely protagonists of cosmic reionization – are not yet fully understood. Using the VLT/MUSE observations of ∼1400 Ly α emitters at 2.9 &amp;lt; z &amp;lt; 6.7, we compare stacked rest-frame UV spectra of candidates for LyC leakers and non-leakers selected based on their Ly α profiles. We find that the stacks of potential LyC leakers, i.e. galaxies with narrow, symmetric Ly α profiles with small peak separation, generally show (i) strong nebular O iii]λ1666, [Si iii]λ1883, and [C iii]λ1907 +C iii]λ1909 emission, indicating a high-ionization state of the interstellar medium (ISM); (ii) high equivalent widths of He iiλ1640 (∼1 − 3 Å), suggesting the presence of hard ionizing radiation fields; (iii) Si ii*λ1533 emission, revealing substantial amounts of neutral hydrogen off the line of sight; (iv) high C ivλλ1548,1550 to [C iii]λ1907 +C iii]λ1909 ratios (C iv/C iii] ≳0.75) , signalling the presence of low column density channels in the ISM. In contrast, the stacks with broad, asymmetric Ly α profiles with large peak separation show weak nebular emission lines, low He iiλ1640 equivalent widths (≲1 Å), and low C iv/C iii] (≲0.25), implying low-ionization states and high-neutral hydrogen column densities. Our results suggest that C iv/C iii] might be sensitive to the physical conditions that govern LyC photon escape, providing a promising tool for identification of ionizing sources among star-forming galaxies in the epoch of reionization."}],"file":[{"success":1,"file_name":"2024_MNAstronomSoc_Kramarenko.pdf","checksum":"9d02df4035c4951cf63dee0db1e462e9","date_updated":"2024-01-23T12:30:45Z","file_id":"14879","creator":"dernst","access_level":"open_access","relation":"main_file","content_type":"application/pdf","date_created":"2024-01-23T12:30:45Z","file_size":4521738}],"publication":"Monthly Notices of the Royal Astronomical Society","publication_status":"published","DOAJ_listed":"1","doi":"10.1093/mnras/stad3853","date_created":"2024-01-22T08:22:17Z","publisher":"Oxford University Press","article_type":"original","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2024-01-30T11:58:02Z","publisher":"Ubiquity Press","article_type":"original","abstract":[{"text":"Global services like navigation, communication, and Earth observation have increased dramatically in the 21st century due to advances in outer space industries. But as orbits become increasingly crowded with both satellites and inevitable space debris pollution, continued operations become endangered by the heightened risks of debris collisions in orbit. Kessler Syndrome is the term for when a critical threshold of orbiting debris triggers a runaway positive feedback loop of debris collisions, creating debris congestion that can render orbits unusable. As this potential tipping point becomes more widely recognized, there have been renewed calls for debris mitigation and removal. Here, we combine complex systems and social-ecological systems approaches to study how these efforts may affect space debris accumulation and the likelihood of reaching Kessler Syndrome. Specifically, we model how debris levels are affected by future launch rates, cleanup activities, and collisions between extant debris. We contextualize and interpret our dynamic model within a discussion of existing space debris governance and other social, economic, and geopolitical factors that may influence effective collective management of the orbital commons. In line with previous studies, our model finds that debris congestion may be reached in less than 200 years, though a holistic management strategy combining removal and mitigation actions can avoid such outcomes while continuing space activities. Moreover, although active debris removal may be particularly effective, the current lack of market and governance support may impede its implementation. Research into these critical dynamics and the multi-faceted variables that influence debris outcomes can support policymakers in curating impactful governance strategies and realistic transition pathways to sustaining debris-free orbits. Overall, our study is useful for communicating about space debris sustainability in policy and education settings by providing an exploration of policy portfolio options supported by a simple and clear social-ecological modeling approach.","lang":"eng"}],"publication":"International Journal of the Commons","file":[{"file_id":"14939","creator":"dernst","date_updated":"2024-02-05T10:06:35Z","file_name":"2023_IntJourCommons_Nomura.pdf","success":1,"checksum":"b80ebc889033c365d8f8c05a0c655382","date_created":"2024-02-05T10:06:35Z","file_size":1305786,"access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"publication_status":"published","doi":"10.5334/ijc.1275","oa_version":"Published Version","publication_identifier":{"issn":["1875-0281"]},"issue":"1","department":[{"_id":"GradSch"},{"_id":"GaTk"}],"acknowledgement":"The authors would like to thank the special issue co-editors, Marco Janssen and Xiao-Shan Yap, and the anonymous reviewers for their comments that helped improve the manuscript. The paper also benefited from suggestions by other author participants in this special issue. We would also like to thank the 2022 Santa Fe Institute Complex Systems Summer School for providing space to initiate this study.","author":[{"last_name":"Nomura","full_name":"Nomura, Keiko","first_name":"Keiko"},{"full_name":"Rella, Simon","last_name":"Rella","first_name":"Simon","id":"B4765ACA-AA38-11E9-AC9A-0930E6697425"},{"first_name":"Haily","full_name":"Merritt, Haily","last_name":"Merritt"},{"first_name":"Mathieu","full_name":"Baltussen, Mathieu","last_name":"Baltussen"},{"first_name":"Darcy","last_name":"Bird","full_name":"Bird, Darcy"},{"first_name":"Annika","last_name":"Tjuka","full_name":"Tjuka, Annika"},{"first_name":"Dan","last_name":"Falk","full_name":"Falk, Dan"}],"scopus_import":"1","intvolume":"        18","day":"11","keyword":["Sociology and Political Science"],"file_date_updated":"2024-02-05T10:06:35Z","citation":{"ieee":"K. Nomura <i>et al.</i>, “Tipping points of space debris in low earth orbit,” <i>International Journal of the Commons</i>, vol. 18, no. 1. Ubiquity Press, 2024.","ista":"Nomura K, Rella S, Merritt H, Baltussen M, Bird D, Tjuka A, Falk D. 2024. Tipping points of space debris in low earth orbit. International Journal of the Commons. 18(1).","apa":"Nomura, K., Rella, S., Merritt, H., Baltussen, M., Bird, D., Tjuka, A., &#38; Falk, D. (2024). Tipping points of space debris in low earth orbit. <i>International Journal of the Commons</i>. Ubiquity Press. <a href=\"https://doi.org/10.5334/ijc.1275\">https://doi.org/10.5334/ijc.1275</a>","mla":"Nomura, Keiko, et al. “Tipping Points of Space Debris in Low Earth Orbit.” <i>International Journal of the Commons</i>, vol. 18, no. 1, Ubiquity Press, 2024, doi:<a href=\"https://doi.org/10.5334/ijc.1275\">10.5334/ijc.1275</a>.","chicago":"Nomura, Keiko, Simon Rella, Haily Merritt, Mathieu Baltussen, Darcy Bird, Annika Tjuka, and Dan Falk. “Tipping Points of Space Debris in Low Earth Orbit.” <i>International Journal of the Commons</i>. Ubiquity Press, 2024. <a href=\"https://doi.org/10.5334/ijc.1275\">https://doi.org/10.5334/ijc.1275</a>.","ama":"Nomura K, Rella S, Merritt H, et al. Tipping points of space debris in low earth orbit. <i>International Journal of the Commons</i>. 2024;18(1). doi:<a href=\"https://doi.org/10.5334/ijc.1275\">10.5334/ijc.1275</a>","short":"K. Nomura, S. Rella, H. Merritt, M. Baltussen, D. Bird, A. Tjuka, D. Falk, International Journal of the Commons 18 (2024)."},"type":"journal_article","article_processing_charge":"Yes","oa":1,"year":"2024","ddc":["550"],"month":"01","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"_id":"14901","date_published":"2024-01-11T00:00:00Z","quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2024-02-05T10:10:27Z","volume":18,"title":"Tipping points of space debris in low earth orbit","status":"public"},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Institute of Science and Technology Austria","date_created":"2024-02-23T14:02:04Z","doi":"10.15479/at:ista:15020","degree_awarded":"PhD","publication_status":"published","file":[{"access_level":"open_access","content_type":"application/pdf","relation":"main_file","date_created":"2024-02-23T13:50:53Z","file_size":7102089,"success":1,"file_name":"hledik thesis pdfa 2b.pdf","checksum":"b2d3da47c98d481577a4baf68944fe41","date_updated":"2024-02-23T13:50:53Z","file_id":"15021","creator":"mhledik"},{"date_created":"2024-02-23T13:50:54Z","file_size":14014790,"access_level":"closed","content_type":"application/zip","relation":"source_file","file_name":"hledik thesis source.zip","checksum":"eda9b9430da2610fee7ce1c1419a479a","file_id":"15022","creator":"mhledik","date_updated":"2024-02-23T14:20:16Z"}],"abstract":[{"lang":"eng","text":"This thesis consists of four distinct pieces of work within theoretical biology, with two themes in common: the concept of optimization in biological systems, and the use of information-theoretic tools to quantify biological stochasticity and statistical uncertainty.\r\nChapter 2 develops a statistical framework for studying biological systems which we believe to be optimized for a particular utility function, such as retinal neurons conveying information about visual stimuli. We formalize such beliefs as maximum-entropy Bayesian priors, constrained by the expected utility. We explore how such priors aid inference of system parameters with limited data and enable optimality hypothesis testing: is the utility higher than by chance?\r\nChapter 3 examines the ultimate biological optimization process: evolution by natural selection. As some individuals survive and reproduce more successfully than others, populations evolve towards fitter genotypes and phenotypes. We formalize this as accumulation of genetic information, and use population genetics theory to study how much such information can be accumulated per generation and maintained in the face of random mutation and genetic drift. We identify the population size and fitness variance as the key quantities that control information accumulation and maintenance.\r\nChapter 4 reuses the concept of genetic information from Chapter 3, but from a different perspective: we ask how much genetic information organisms actually need, in particular in the context of gene regulation. For example, how much information is needed to bind transcription factors at correct locations within the genome? Population genetics provides us with a refined answer: with an increasing population size, populations achieve higher fitness by maintaining more genetic information. Moreover, regulatory parameters experience selection pressure to optimize the fitness-information trade-off, i.e. minimize the information needed for a given fitness. This provides an evolutionary derivation of the optimization priors introduced in Chapter 2.\r\nChapter 5 proves an upper bound on mutual information between a signal and a communication channel output (such as neural activity). Mutual information is an important utility measure for biological systems, but its practical use can be difficult due to the large dimensionality of many biological channels. Sometimes, a lower bound on mutual information is computed by replacing the high-dimensional channel outputs with decodes (signal estimates). Our result provides a corresponding upper bound, provided that the decodes are the maximum posterior estimates of the signal."}],"publication_identifier":{"issn":["2663-337X"]},"oa_version":"Published Version","department":[{"_id":"GradSch"},{"_id":"NiBa"},{"_id":"GaTk"}],"project":[{"call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program"},{"_id":"2665AAFE-B435-11E9-9278-68D0E5697425","name":"Can evolution minimize spurious signaling crosstalk to reach optimal performance?","grant_number":"RGP0034/2018"},{"_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","grant_number":"101055327","name":"Understanding the evolution of continuous genomes"}],"ec_funded":1,"author":[{"id":"4171253A-F248-11E8-B48F-1D18A9856A87","first_name":"Michal","last_name":"Hledik","full_name":"Hledik, Michal"}],"keyword":["Theoretical biology","Optimality","Evolution","Information"],"OA_place":"publisher","file_date_updated":"2024-02-23T14:20:16Z","day":"23","oa":1,"type":"dissertation","article_processing_charge":"No","citation":{"short":"M. Hledik, Genetic Information and Biological Optimization, Institute of Science and Technology Austria, 2024.","ama":"Hledik M. Genetic information and biological optimization. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:15020\">10.15479/at:ista:15020</a>","chicago":"Hledik, Michal. “Genetic Information and Biological Optimization.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:15020\">https://doi.org/10.15479/at:ista:15020</a>.","apa":"Hledik, M. (2024). <i>Genetic information and biological optimization</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:15020\">https://doi.org/10.15479/at:ista:15020</a>","ista":"Hledik M. 2024. Genetic information and biological optimization. Institute of Science and Technology Austria.","mla":"Hledik, Michal. <i>Genetic Information and Biological Optimization</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:15020\">10.15479/at:ista:15020</a>.","ieee":"M. Hledik, “Genetic information and biological optimization,” Institute of Science and Technology Austria, 2024."},"year":"2024","ddc":["576","519"],"related_material":{"record":[{"relation":"part_of_dissertation","id":"7606","status":"public"},{"relation":"part_of_dissertation","id":"12081","status":"public"},{"relation":"part_of_dissertation","id":"7553","status":"public"}]},"has_accepted_license":"1","month":"02","alternative_title":["ISTA Thesis"],"date_published":"2024-02-23T00:00:00Z","_id":"15020","date_updated":"2026-04-07T12:59:25Z","language":[{"iso":"eng"}],"title":"Genetic information and biological optimization","acknowledged_ssus":[{"_id":"ScienComp"}],"status":"public","supervisor":[{"last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"},{"last_name":"Tkačik","full_name":"Tkačik, Gašper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gašper","orcid":"0000-0002-6699-1455"}],"page":"158","corr_author":"1"},{"OA_place":"publisher","file_date_updated":"2024-03-14T14:14:35Z","day":"08","citation":{"ieee":"S. Cultrera di Montesano, “Persistence and Morse theory for discrete geometric structures,” Institute of Science and Technology Austria, 2024.","mla":"Cultrera di Montesano, Sebastiano. <i>Persistence and Morse Theory for Discrete Geometric Structures</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:15094\">10.15479/at:ista:15094</a>.","apa":"Cultrera di Montesano, S. (2024). <i>Persistence and Morse theory for discrete geometric structures</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:15094\">https://doi.org/10.15479/at:ista:15094</a>","ista":"Cultrera di Montesano S. 2024. Persistence and Morse theory for discrete geometric structures. Institute of Science and Technology Austria.","chicago":"Cultrera di Montesano, Sebastiano. “Persistence and Morse Theory for Discrete Geometric Structures.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:15094\">https://doi.org/10.15479/at:ista:15094</a>.","ama":"Cultrera di Montesano S. Persistence and Morse theory for discrete geometric structures. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:15094\">10.15479/at:ista:15094</a>","short":"S. Cultrera di Montesano, Persistence and Morse Theory for Discrete Geometric Structures, Institute of Science and Technology Austria, 2024."},"oa":1,"article_processing_charge":"No","type":"dissertation","ec_funded":1,"department":[{"_id":"GradSch"},{"_id":"HeEd"}],"project":[{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"268116B8-B435-11E9-9278-68D0E5697425","name":"Mathematics, Computer Science","grant_number":"Z00342"},{"_id":"0aa4bc98-070f-11eb-9043-e6fff9c6a316","name":"Persistent Homology, Algorithms and Stochastic Geometry","grant_number":"I4887"},{"call_identifier":"FWF","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","grant_number":"I02979-N35","name":"Persistence and stability of geometric complexes"}],"author":[{"full_name":"Cultrera di Montesano, Sebastiano","last_name":"Cultrera di Montesano","orcid":"0000-0001-6249-0832","id":"34D2A09C-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastiano"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Point sets, geometric networks, and arrangements of hyperplanes are fundamental objects in\r\ndiscrete geometry that have captivated mathematicians for centuries, if not millennia. This\r\nthesis seeks to cast new light on these structures by illustrating specific instances where a\r\ntopological perspective, specifically through discrete Morse theory and persistent homology,\r\nprovides valuable insights.\r\n\r\nAt first glance, the topology of these geometric objects might seem uneventful: point sets\r\nessentially lack of topology, arrangements of hyperplanes are a decomposition of Rd, which\r\nis a contractible space, and the topology of a network primarily involves the enumeration\r\nof connected components and cycles within the network. However, beneath this apparent\r\nsimplicity, there lies an array of intriguing structures, a small subset of which will be uncovered\r\nin this thesis.\r\n\r\nFocused on three case studies, each addressing one of the mentioned objects, this work\r\nwill showcase connections that intertwine topology with diverse fields such as combinatorial\r\ngeometry, algorithms and data structures, and emerging applications like spatial biology.\r\n\r\n"}],"file":[{"file_name":"Thesis Sebastiano.pdf","success":1,"checksum":"1e468bfa42a7dcf04d89f4dadc621c87","date_updated":"2024-03-14T08:55:07Z","file_id":"15112","creator":"scultrer","access_level":"open_access","content_type":"application/pdf","relation":"main_file","date_created":"2024-03-14T08:55:07Z","file_size":4106872},{"date_created":"2024-03-14T08:56:24Z","file_size":4746234,"access_level":"closed","content_type":"application/zip","relation":"source_file","file_id":"15113","creator":"scultrer","date_updated":"2024-03-14T14:14:35Z","file_name":"Thesis (1).zip","checksum":"bcbd213490f5a7e68855a092bbce93f1"}],"doi":"10.15479/at:ista:15094","degree_awarded":"PhD","publication_identifier":{"issn":["2663-337X"]},"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2024-03-08T15:28:10Z","publisher":"Institute of Science and Technology Austria","status":"public","page":"108","corr_author":"1","supervisor":[{"full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","orcid":"0000-0002-9823-6833"}],"title":"Persistence and Morse theory for discrete geometric structures","date_published":"2024-03-08T00:00:00Z","_id":"15094","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}],"date_updated":"2026-04-07T12:58:48Z","ddc":["514","500","516"],"year":"2024","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"has_accepted_license":"1","month":"03","related_material":{"record":[{"relation":"part_of_dissertation","id":"15091","status":"public"},{"relation":"part_of_dissertation","id":"11660","status":"public"},{"id":"15090","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"15093"},{"status":"public","relation":"part_of_dissertation","id":"13182"},{"status":"public","id":"11658","relation":"part_of_dissertation"}]}},{"date_created":"2024-05-05T22:01:04Z","publisher":"American Physical Society","article_type":"original","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Preprint","publication_identifier":{"eissn":["2331-7019"]},"abstract":[{"text":"We investigate superradiant enhancements in the refrigeration performance of a set of N three-level systems that are collectively coupled to a hot and a cold thermal reservoir and are additionally subject to collective periodic (circular) driving. Assuming the system-reservoir coupling to be weak, we explore the regime of stronger periodic driving strengths by comparing collective weak driving, Floquet-Lindblad, and Floquet-Redfield master equations. We identify regimes where the power injected by the periodic driving is used to pump heat from the cold to the hot reservoir and derive analytic sufficient conditions for them based on a cycle analysis of the Floquet-Lindblad master equation. In those regimes, we also argue for which parameters collective enhancements like a quadratic scaling of the cooling current with N can be expected and support our arguments by numerical simulations.","lang":"eng"}],"publication":"Physical Review Applied","publication_status":"published","doi":"10.1103/PhysRevApplied.21.044050","author":[{"first_name":"Dmytro","id":"530a7320-5355-11ee-ae5a-82a46997aaa7","full_name":"Kolisnyk, Dmytro","last_name":"Kolisnyk"},{"last_name":"Queißer","full_name":"Queißer, Friedemann","first_name":"Friedemann"},{"full_name":"Schaller, Gernot","last_name":"Schaller","first_name":"Gernot"},{"full_name":"Schützhold, Ralf","last_name":"Schützhold","first_name":"Ralf"}],"article_number":"044050","scopus_import":"1","external_id":{"arxiv":["2310.18126"],"isi":["001226579400001"]},"isi":1,"acknowledgement":"Financial support by the DFG (project ID 278162697 – SFB 1242) is gratefully acknowledged.\r\n","department":[{"_id":"GradSch"}],"issue":"4","citation":{"short":"D. Kolisnyk, F. Queißer, G. Schaller, R. Schützhold, Physical Review Applied 21 (2024).","ama":"Kolisnyk D, Queißer F, Schaller G, Schützhold R. Floquet analysis of a superradiant many-qutrit refrigerator. <i>Physical Review Applied</i>. 2024;21(4). doi:<a href=\"https://doi.org/10.1103/PhysRevApplied.21.044050\">10.1103/PhysRevApplied.21.044050</a>","chicago":"Kolisnyk, Dmytro, Friedemann Queißer, Gernot Schaller, and Ralf Schützhold. “Floquet Analysis of a Superradiant Many-Qutrit Refrigerator.” <i>Physical Review Applied</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/PhysRevApplied.21.044050\">https://doi.org/10.1103/PhysRevApplied.21.044050</a>.","mla":"Kolisnyk, Dmytro, et al. “Floquet Analysis of a Superradiant Many-Qutrit Refrigerator.” <i>Physical Review Applied</i>, vol. 21, no. 4, 044050, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/PhysRevApplied.21.044050\">10.1103/PhysRevApplied.21.044050</a>.","apa":"Kolisnyk, D., Queißer, F., Schaller, G., &#38; Schützhold, R. (2024). Floquet analysis of a superradiant many-qutrit refrigerator. <i>Physical Review Applied</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevApplied.21.044050\">https://doi.org/10.1103/PhysRevApplied.21.044050</a>","ista":"Kolisnyk D, Queißer F, Schaller G, Schützhold R. 2024. Floquet analysis of a superradiant many-qutrit refrigerator. Physical Review Applied. 21(4), 044050.","ieee":"D. Kolisnyk, F. Queißer, G. Schaller, and R. Schützhold, “Floquet analysis of a superradiant many-qutrit refrigerator,” <i>Physical Review Applied</i>, vol. 21, no. 4. American Physical Society, 2024."},"article_processing_charge":"No","type":"journal_article","oa":1,"intvolume":"        21","day":"26","month":"04","year":"2024","quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2025-09-04T13:51:06Z","_id":"15360","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2310.18126","open_access":"1"}],"date_published":"2024-04-26T00:00:00Z","volume":21,"title":"Floquet analysis of a superradiant many-qutrit refrigerator","arxiv":1,"status":"public"},{"intvolume":"         5","OA_place":"publisher","file_date_updated":"2024-05-21T09:35:14Z","day":"01","citation":{"chicago":"Finžgar, Jernej Rudi, Aron Kerschbaumer, Martin J.A. Schuetz, Christian B. Mendl, and Helmut G. Katzgraber. “Quantum-Informed Recursive Optimization Algorithms.” <i>PRX Quantum</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/PRXQuantum.5.020327\">https://doi.org/10.1103/PRXQuantum.5.020327</a>.","short":"J.R. Finžgar, A. Kerschbaumer, M.J.A. Schuetz, C.B. Mendl, H.G. Katzgraber, PRX Quantum 5 (2024).","ama":"Finžgar JR, Kerschbaumer A, Schuetz MJA, Mendl CB, Katzgraber HG. Quantum-informed recursive optimization algorithms. <i>PRX Quantum</i>. 2024;5(2). doi:<a href=\"https://doi.org/10.1103/PRXQuantum.5.020327\">10.1103/PRXQuantum.5.020327</a>","ieee":"J. R. Finžgar, A. Kerschbaumer, M. J. A. Schuetz, C. B. Mendl, and H. G. Katzgraber, “Quantum-informed recursive optimization algorithms,” <i>PRX Quantum</i>, vol. 5, no. 2. American Physical Society, 2024.","apa":"Finžgar, J. R., Kerschbaumer, A., Schuetz, M. J. A., Mendl, C. B., &#38; Katzgraber, H. G. (2024). Quantum-informed recursive optimization algorithms. <i>PRX Quantum</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PRXQuantum.5.020327\">https://doi.org/10.1103/PRXQuantum.5.020327</a>","ista":"Finžgar JR, Kerschbaumer A, Schuetz MJA, Mendl CB, Katzgraber HG. 2024. Quantum-informed recursive optimization algorithms. PRX Quantum. 5(2), 020327.","mla":"Finžgar, Jernej Rudi, et al. “Quantum-Informed Recursive Optimization Algorithms.” <i>PRX Quantum</i>, vol. 5, no. 2, 020327, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/PRXQuantum.5.020327\">10.1103/PRXQuantum.5.020327</a>."},"oa":1,"type":"journal_article","article_processing_charge":"Yes","issue":"2","acknowledgement":"J.R.F. and A.K. thank Libor Caha and Alexander Kliesch for insightful discussions. The authors thank Lilly Palackal, Maximilian Passek, Carlos Riofrío, and Gili Rosenberg for thorough reviews of the manuscript, and the Amazon Braket, BMW, and QuEra teams for their support. C.M. thanks the Munich Quantum Valley initiative, which is supported by the Bavarian State Government with funds from the Hightech Agenda Bayern Plus. H.G.K. would like to thank Am Platzl 1A for providing the necessary environment for creative thinking. An open-source implementation of QIRO is available online [60].","department":[{"_id":"GradSch"}],"author":[{"last_name":"Finžgar","full_name":"Finžgar, Jernej Rudi","first_name":"Jernej Rudi"},{"first_name":"Aron","id":"ade85a9c-3200-11ee-973b-91c1eb240410","last_name":"Kerschbaumer","full_name":"Kerschbaumer, Aron"},{"full_name":"Schuetz, Martin J.A.","last_name":"Schuetz","first_name":"Martin J.A."},{"last_name":"Mendl","full_name":"Mendl, Christian B.","first_name":"Christian B."},{"full_name":"Katzgraber, Helmut G.","last_name":"Katzgraber","first_name":"Helmut G."}],"OA_type":"gold","external_id":{"arxiv":["2308.13607"]},"article_number":"020327","scopus_import":"1","publication_status":"published","file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_size":2016085,"date_created":"2024-05-21T09:35:14Z","date_updated":"2024-05-21T09:35:14Z","creator":"dernst","file_id":"15409","checksum":"76bdf0b4dc06d59d073a57bd6957a96c","file_name":"2024_PRXQuantum_Finzgar.pdf","success":1}],"abstract":[{"lang":"eng","text":"We propose and implement a family of quantum-informed recursive optimization (QIRO) algorithms for combinatorial optimization problems. Our approach leverages quantum resources to obtain information that is used in problem-specific classical reduction steps that recursively simplify the problem. These reduction steps address the limitations of the quantum component (e.g., locality) and ensure solution feasibility in constrained optimization problems. Additionally, we use backtracking techniques to further improve the performance of the algorithm without increasing the requirements on the quantum hardware. We showcase the capabilities of our approach by informing QIRO with correlations from classical simulations of shallow circuits of the quantum approximate optimization algorithm, solving instances of maximum independent set and maximum satisfiability problems with hundreds of variables. We also demonstrate how QIRO can be deployed on a neutral atom quantum processor to find large independent sets of graphs. In summary, our scheme achieves results comparable to classical heuristics even with relatively weak quantum resources. Furthermore, enhancing the quality of these quantum resources improves the performance of the algorithms. Notably, the modular nature of QIRO offers various avenues for modifications, positioning our work as a template for a broader class of hybrid quantum-classical algorithms for combinatorial optimization."}],"publication":"PRX Quantum","doi":"10.1103/PRXQuantum.5.020327","DOAJ_listed":"1","publication_identifier":{"eissn":["2691-3399"]},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2024-05-19T22:01:13Z","article_type":"original","publisher":"American Physical Society","status":"public","corr_author":"1","arxiv":1,"volume":5,"title":"Quantum-informed recursive optimization algorithms","date_published":"2024-05-01T00:00:00Z","_id":"15407","quality_controlled":"1","language":[{"iso":"eng"}],"date_updated":"2025-05-14T09:29:40Z","ddc":["530"],"year":"2024","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"month":"05"},{"title":"Dynamics of a rank-one multiplicative perturbation of a unitary matrix","volume":13,"status":"public","corr_author":"1","arxiv":1,"year":"2024","related_material":{"record":[{"status":"public","id":"17164","relation":"dissertation_contains"}]},"month":"04","date_published":"2024-04-01T00:00:00Z","_id":"17047","main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2212.14638","open_access":"1"}],"language":[{"iso":"eng"}],"date_updated":"2026-04-07T13:02:12Z","quality_controlled":"1","issue":"2","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"project":[{"call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331"}],"ec_funded":1,"external_id":{"arxiv":["2212.14638"],"isi":["001229295200002"]},"isi":1,"article_number":"2450007","scopus_import":"1","author":[{"id":"D5C6A458-10C4-11EA-ABF4-A4B43DDC885E","first_name":"Guillaume","orcid":"0000-0001-6892-8137","full_name":"Dubach, Guillaume","last_name":"Dubach"},{"id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9","first_name":"Jana","last_name":"Reker","full_name":"Reker, Jana"}],"OA_type":"green","OA_place":"repository","day":"01","intvolume":"        13","oa":1,"type":"journal_article","article_processing_charge":"No","citation":{"short":"G. Dubach, J. Reker, Random Matrices: Theory and Applications 13 (2024).","ama":"Dubach G, Reker J. Dynamics of a rank-one multiplicative perturbation of a unitary matrix. <i>Random Matrices: Theory and Applications</i>. 2024;13(2). doi:<a href=\"https://doi.org/10.1142/s2010326324500072\">10.1142/s2010326324500072</a>","chicago":"Dubach, Guillaume, and Jana Reker. “Dynamics of a Rank-One Multiplicative Perturbation of a Unitary Matrix.” <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing, 2024. <a href=\"https://doi.org/10.1142/s2010326324500072\">https://doi.org/10.1142/s2010326324500072</a>.","mla":"Dubach, Guillaume, and Jana Reker. “Dynamics of a Rank-One Multiplicative Perturbation of a Unitary Matrix.” <i>Random Matrices: Theory and Applications</i>, vol. 13, no. 2, 2450007, World Scientific Publishing, 2024, doi:<a href=\"https://doi.org/10.1142/s2010326324500072\">10.1142/s2010326324500072</a>.","ista":"Dubach G, Reker J. 2024. Dynamics of a rank-one multiplicative perturbation of a unitary matrix. Random Matrices: Theory and Applications. 13(2), 2450007.","apa":"Dubach, G., &#38; Reker, J. (2024). Dynamics of a rank-one multiplicative perturbation of a unitary matrix. <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/s2010326324500072\">https://doi.org/10.1142/s2010326324500072</a>","ieee":"G. Dubach and J. Reker, “Dynamics of a rank-one multiplicative perturbation of a unitary matrix,” <i>Random Matrices: Theory and Applications</i>, vol. 13, no. 2. World Scientific Publishing, 2024."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","publisher":"World Scientific Publishing","date_created":"2024-05-23T08:31:57Z","doi":"10.1142/s2010326324500072","publication_status":"published","abstract":[{"lang":"eng","text":"We provide a dynamical study of a model of multiplicative perturbation of a unitary matrix introduced by Fyodorov. In particular, we identify a flow of deterministic domains that bound the spectrum with high probability, separating the outlier from the typical eigenvalues at all sub-critical timescales. These results are obtained under generic assumptions on U that hold for a variety of unitary random matrix models."}],"publication":"Random Matrices: Theory and Applications","publication_identifier":{"issn":["2010-3263"],"eissn":["2010-3271"]},"oa_version":"Preprint"},{"supervisor":[{"orcid":"0000-0001-8112-028X","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","last_name":"Fink","full_name":"Fink, Johannes M"}],"page":"161","corr_author":"1","status":"public","acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"M-Shop"}],"title":"Superconducting qubits capable of dynamic switching between protected and high-speed control regimes","date_updated":"2026-04-15T06:43:02Z","language":[{"iso":"eng"}],"alternative_title":["ISTA Thesis"],"date_published":"2024-06-11T00:00:00Z","_id":"17133","related_material":{"record":[{"status":"public","id":"13227","relation":"part_of_dissertation"},{"status":"public","id":"9928","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"8755","status":"public"}]},"has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"month":"06","year":"2024","ddc":["530"],"oa":1,"type":"dissertation","article_processing_charge":"No","citation":{"chicago":"Hassani, Farid. “Superconducting Qubits Capable of Dynamic Switching between Protected and High-Speed Control Regimes.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:17133\">https://doi.org/10.15479/at:ista:17133</a>.","ama":"Hassani F. Superconducting qubits capable of dynamic switching between protected and high-speed control regimes. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:17133\">10.15479/at:ista:17133</a>","short":"F. Hassani, Superconducting Qubits Capable of Dynamic Switching between Protected and High-Speed Control Regimes, Institute of Science and Technology Austria, 2024.","ieee":"F. Hassani, “Superconducting qubits capable of dynamic switching between protected and high-speed control regimes,” Institute of Science and Technology Austria, 2024.","apa":"Hassani, F. (2024). <i>Superconducting qubits capable of dynamic switching between protected and high-speed control regimes</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:17133\">https://doi.org/10.15479/at:ista:17133</a>","ista":"Hassani F. 2024. Superconducting qubits capable of dynamic switching between protected and high-speed control regimes. Institute of Science and Technology Austria.","mla":"Hassani, Farid. <i>Superconducting Qubits Capable of Dynamic Switching between Protected and High-Speed Control Regimes</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:17133\">10.15479/at:ista:17133</a>."},"keyword":["Quantum information","Qubits","Superconducting devices"],"OA_place":"publisher","file_date_updated":"2024-06-20T11:52:22Z","day":"11","author":[{"orcid":"0000-0001-6937-5773","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","first_name":"Farid","last_name":"Hassani","full_name":"Hassani, Farid"}],"department":[{"_id":"GradSch"},{"_id":"JoFi"}],"project":[{"_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A","name":"NOMIS Fellowship Program"},{"name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","grant_number":"F07105"}],"publication_identifier":{"isbn":["978-3-99078-040-4"],"issn":["2663-337X"]},"oa_version":"Published Version","doi":"10.15479/at:ista:17133","degree_awarded":"PhD","publication_status":"published","file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","date_created":"2024-06-12T07:53:19Z","file_size":28370759,"date_updated":"2024-06-20T11:52:22Z","file_id":"17137","creator":"fhassani","file_name":"Thesis_main_final.pdf","checksum":"258c353d47fa37ea63ea43b1e10a34a0"},{"checksum":"deffa5d0db88093f74812fa71520d5e1","file_name":"Thesis_main.tex","date_updated":"2024-06-12T07:54:27Z","creator":"fhassani","file_id":"17138","relation":"source_file","content_type":"text/x-tex","access_level":"closed","file_size":445735,"date_created":"2024-06-12T07:54:27Z"}],"abstract":[{"lang":"eng","text":"An ideal quantum computer relies on qubits capable of performing fast gate operations and\r\nmaintaining strong interconnections while preserving their quantum coherence. Since the\r\ninception of experimental eforts toward building a quantum computer, the community has\r\nfaced challenges in engineering such a system. Among the various methods of implementing a\r\nquantum computer, superconducting qubits have shown fast gates close to tens of nanoseconds,\r\nwith the state-of-the-art reaching a coherence of a few milliseconds. However, achieving\r\nsimultaneously long lifetimes with fast qubit operations poses an inherent paradox. Qubits\r\nwith high coherence require isolation from the environment, while fast operation necessitates\r\nstrong coupling of the qubit. This thesis approaches this issue by proposing the idea of\r\nengineering superconducting qubits capable of transitioning between operating in a protected\r\nregime, where the qubit is completely isolated from the environment, and coupling to the\r\ncommunication channels as needed. In this direction, we use the geometric superinductor to\r\nscan the parameter space of rf-SQUID devices, searching for a regime where we can take the\r\nqubit protection to its extreme.\r\n\r\nThis leads us to the inductively shunted transmon (IST) regime, characterized by EJ /EC ≫ 1\r\nand EJ /EL ≫ 1, where the circuit potential exhibits a double well with a large barrier\r\nseparating the local ground states of each quantum well. In this regime, although it is\r\nanticipated that the two quantum wells would be isolated from each other, we observe single\r\nfuxon tunneling between them. The interplay of the cavity photons and the fuxon transition\r\nforms a rich physical system, containing resonance conditions that allow the preparation of the\r\nfuxon ground or excited states. This enables us to study the relaxation rate of such transition\r\nand show that it can be as large as 3.6 hours. Dynamically controlling the barrier height\r\nbetween the two quantum wells allows for controllable coupling, which scales exponentially,\r\nfor a qubit encoded in two fuxon states.\r\nThe 0-π qubit is one of the very few known superconducting circuit types that ofers exponential\r\nprotection from both relaxation and dephasing simultaneously. However, this qubit is not\r\nexempt from the fact that such protection comes at the expense of complex readout and\r\ncontrol. In this thesis, we propose a way to controllably break the circuit symmetry, the\r\nkey reason for the protection, to momentarily restore the ability to control and manipulate\r\nthe qubit. An asymmetry in capacitances and inductances in the 0-π circuit is detrimental\r\nsince they lead to coupling of the protected state to the thermally occupied parasitic mode\r\nof the circuit. However, here we try to exploit a controlled asymmetry in Josephson energies\r\nand show that this can be used as a tunable coupler between the protected states. In the\r\nfuture, this should allow to perform gate operations by dynamically controlling the asymmetry\r\ninstead of driving the protected transition with microwave pulses. Therefore, we believe that\r\nthe proposed method can make the use of protected qubits more practical in experimental\r\nrealizations of quantum computing."}],"publisher":"Institute of Science and Technology Austria","date_created":"2024-06-11T18:20:05Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"year":"2024","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2024-06-12T07:01:52Z","month":"06","doi":"10.48550/arXiv.2406.07026","date_published":"2024-06-11T00:00:00Z","publication_status":"submitted","_id":"17136","publication":"arXiv","abstract":[{"lang":"eng","text":"This paper focuses on Majority Dynamics in sparse graphs, in particular, as a\r\ntool to study internal cuts. It is known that, in Majority Dynamics on a finite\r\ngraph, each vertex eventually either comes to a fixed state, or oscillates with\r\nperiod two. The empirical evidence acquired by simulations suggests that for\r\nrandom odd-regular graphs, approximately half of the vertices end up\r\noscillating with high probability. We notice a local symmetry between\r\noscillating and non-oscillating vertices, that potentially can explain why the\r\nfraction of the oscillating vertices is concentrated around $\\frac{1}{2}$. In\r\nour simulations, we observe that the parts of random odd-regular graph under\r\nMajority Dynamics with high probability do not contain $\\lceil \\frac{d}{2}\r\n\\rceil$-cores at any timestep, and thus, one cannot use Majority Dynamics to\r\nprove that internal cuts exist in odd-regular graphs almost surely. However, we\r\nsuggest a modification of Majority Dynamics, that yields parts with desired\r\ncores with high probability."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2406.07026"}],"language":[{"iso":"eng"}],"date_updated":"2024-06-17T10:45:32Z","oa_version":"Preprint","acknowledgement":"I am grateful to Matthew Kwan for setting the problem, providing useful literature,\r\nfruitful discussions, text review, mentorship, general encouragement and support.","department":[{"_id":"GradSch"}],"title":"Majority dynamics and internal partitions of random regular graphs: Experimental results","external_id":{"arxiv":["2406.07026"]},"article_number":"2406.07026","author":[{"last_name":"Arkhipov","full_name":"Arkhipov, Pavel","id":"b25f2ab2-1fed-11ee-8599-fe02d211784f","first_name":"Pavel"}],"day":"11","status":"public","oa":1,"article_processing_charge":"No","type":"preprint","citation":{"ama":"Arkhipov P. Majority dynamics and internal partitions of random regular graphs: Experimental results. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2406.07026\">10.48550/arXiv.2406.07026</a>","short":"P. Arkhipov, ArXiv (n.d.).","chicago":"Arkhipov, Pavel. “Majority Dynamics and Internal Partitions of Random Regular Graphs: Experimental Results.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2406.07026\">https://doi.org/10.48550/arXiv.2406.07026</a>.","ista":"Arkhipov P. Majority dynamics and internal partitions of random regular graphs: Experimental results. arXiv, 2406.07026.","apa":"Arkhipov, P. (n.d.). Majority dynamics and internal partitions of random regular graphs: Experimental results. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2406.07026\">https://doi.org/10.48550/arXiv.2406.07026</a>","mla":"Arkhipov, Pavel. “Majority Dynamics and Internal Partitions of Random Regular Graphs: Experimental Results.” <i>ArXiv</i>, 2406.07026, doi:<a href=\"https://doi.org/10.48550/arXiv.2406.07026\">10.48550/arXiv.2406.07026</a>.","ieee":"P. Arkhipov, “Majority dynamics and internal partitions of random regular graphs: Experimental results,” <i>arXiv</i>. ."},"arxiv":1},{"intvolume":"        75","file_date_updated":"2025-01-02T10:26:22Z","OA_place":"publisher","day":"27","citation":{"chicago":"Zhang, Zilin, Huihuang Chen, Shuaiying Peng, and Huibin Han. “Slow and Rapid Auxin Responses in Arabidopsis.” <i>Journal of Experimental Botany</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jxb/erae246\">https://doi.org/10.1093/jxb/erae246</a>.","short":"Z. Zhang, H. Chen, S. Peng, H. Han, Journal of Experimental Botany 75 (2024).","ama":"Zhang Z, Chen H, Peng S, Han H. Slow and rapid auxin responses in Arabidopsis. <i>Journal of Experimental Botany</i>. 2024;75(18). doi:<a href=\"https://doi.org/10.1093/jxb/erae246\">10.1093/jxb/erae246</a>","ieee":"Z. Zhang, H. Chen, S. Peng, and H. Han, “Slow and rapid auxin responses in Arabidopsis,” <i>Journal of Experimental Botany</i>, vol. 75, no. 18. Oxford University Press, 2024.","apa":"Zhang, Z., Chen, H., Peng, S., &#38; Han, H. (2024). Slow and rapid auxin responses in Arabidopsis. <i>Journal of Experimental Botany</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jxb/erae246\">https://doi.org/10.1093/jxb/erae246</a>","ista":"Zhang Z, Chen H, Peng S, Han H. 2024. Slow and rapid auxin responses in Arabidopsis. Journal of Experimental Botany. 75(18), erae246.","mla":"Zhang, Zilin, et al. “Slow and Rapid Auxin Responses in Arabidopsis.” <i>Journal of Experimental Botany</i>, vol. 75, no. 18, erae246, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/jxb/erae246\">10.1093/jxb/erae246</a>."},"oa":1,"article_processing_charge":"No","type":"journal_article","acknowledgement":"We thank other lab members for their critical comments on this manuscript. We also thank the editor and reviewers for their constructive comments to improve our manuscript. We apologize to authors whose important work we could not include due to space limitations.\r\nThis work is supported by funding from Jiangxi Agricultural University (9232308314) and the Science and Technology Department of Jiangxi Province (20223BCJ25037) to HBH, and the Science and Technology Department of Jiangxi Province (20202ACB215002) to SYP.","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"issue":"18","author":[{"last_name":"Zhang","full_name":"Zhang, Zilin","first_name":"Zilin"},{"first_name":"Huihuang","id":"83c96512-15b2-11ec-abd3-b7eede36184f","full_name":"Chen, Huihuang","last_name":"Chen"},{"full_name":"Peng, Shuaiying","last_name":"Peng","first_name":"Shuaiying"},{"first_name":"Huibin","full_name":"Han, Huibin","last_name":"Han"}],"OA_type":"hybrid","external_id":{"pmid":["38794966"],"isi":["001270051200001"]},"isi":1,"scopus_import":"1","article_number":"erae246","publication_status":"published","file":[{"checksum":"91b9435ed0f6640809c7588df19abf2f","success":1,"file_name":"2024_JourExperimentalBotany_Zhang.pdf","creator":"dernst","file_id":"18720","date_updated":"2025-01-02T10:26:22Z","file_size":763097,"date_created":"2025-01-02T10:26:22Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access"}],"publication":"Journal of Experimental Botany","abstract":[{"lang":"eng","text":"The TIR1/AFB–Aux/IAA–ARF canonical auxin signaling pathway is widely accepted to (de)active transcriptional regulation, thus controlling auxin-associated developmental processes. However, the theme of a rapid auxin response has emerged since the 2018 Auxins and Cytokinin in Plant Development conference. To date, a few signaling components have been identified to mediate both slow and rapid auxin responses, which unveils the complexity of auxin signaling."}],"doi":"10.1093/jxb/erae246","publication_identifier":{"issn":["0022-0957"]},"pmid":1,"oa_version":"Published Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-06-15T19:50:15Z","publisher":"Oxford University Press","article_type":"original","status":"public","volume":75,"title":"Slow and rapid auxin responses in Arabidopsis","date_published":"2024-09-27T00:00:00Z","_id":"17141","quality_controlled":"1","date_updated":"2025-09-08T07:57:50Z","language":[{"iso":"eng"}],"year":"2024","ddc":["580"],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"has_accepted_license":"1","month":"09"},{"day":"25","keyword":["equivariant cohomology","zero schemes","algebraic groups","Lie algebras"],"OA_place":"publisher","file_date_updated":"2024-06-26T21:00:14Z","citation":{"ieee":"K. P. Rychlewicz, “Equivariant cohomology and rings of functions,” Institute of Science and Technology Austria, 2024.","ista":"Rychlewicz KP. 2024. Equivariant cohomology and rings of functions. Institute of Science and Technology Austria.","apa":"Rychlewicz, K. P. (2024). <i>Equivariant cohomology and rings of functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:17156\">https://doi.org/10.15479/at:ista:17156</a>","mla":"Rychlewicz, Kamil P. <i>Equivariant Cohomology and Rings of Functions</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:17156\">10.15479/at:ista:17156</a>.","chicago":"Rychlewicz, Kamil P. “Equivariant Cohomology and Rings of Functions.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:17156\">https://doi.org/10.15479/at:ista:17156</a>.","short":"K.P. Rychlewicz, Equivariant Cohomology and Rings of Functions, Institute of Science and Technology Austria, 2024.","ama":"Rychlewicz KP. Equivariant cohomology and rings of functions. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:17156\">10.15479/at:ista:17156</a>"},"type":"dissertation","article_processing_charge":"No","oa":1,"project":[{"grant_number":"26525","_id":"34cd0f74-11ca-11ed-8bc3-bf0492a14a24","name":"Topology of open smooth varieties with a torus action"}],"department":[{"_id":"TaHa"},{"_id":"GradSch"}],"author":[{"id":"85A07246-A8BF-11E9-B4FA-D9E3E5697425","first_name":"Kamil P","last_name":"Rychlewicz","full_name":"Rychlewicz, Kamil P"}],"abstract":[{"lang":"eng","text":"This dissertation is the summary of the author’s work, concerning the relations between\r\ncohomology rings of algebraic varieties and rings of functions on zero schemes and fixed\r\npoint schemes. For most of the thesis, the focus is on smooth complex varieties with\r\nan action of a principally paired group, e.g. a parabolic subgroup of a reductive group.\r\nThe fundamental theorem 5.2.11 from co-authored article [66] says that if the principal\r\nnilpotent has a unique zero, then the zero scheme over the Kostant section is isomorphic\r\nto the spectrum of the equivariant cohomology ring, remembering the grading in terms of\r\na C^* action. A similar statement is proved also for the G-invariant functions on the total\r\nzero scheme over the whole Lie algebra. Additionally, we are able to prove an analogous\r\nresult for the GKM spaces, which poses the question on a joint generalisation.\r\nWe also tackle the situation of a singular variety. As long as it is embedded in a smooth\r\nvariety with regular action, we are able to study its cohomology as well by means of\r\nthe zero scheme. In case of e.g. Schubert varieties this determines the cohomology ring\r\ncompletely. In largest generality, this allows us to see a significant part of the cohomology\r\nring.\r\nWe also show (Theorem 6.2.1) that the cohomology ring of spherical varieties appears as\r\nthe ring of functions on the zero scheme. The computational aspect is not easy, but one\r\ncan hope that this can bring some concrete information about such cohomology rings.\r\nLastly, the K-theory conjecture 6.3.1 is studied, with some results attained for GKM\r\nspaces.\r\nThe thesis includes also an introduction to group actions on algebraic varieties. In\r\nparticular, the vector fields associated to the actions are extensively studied. We also\r\nprovide a version of the Kostant section for arbitrary principally paired group, which\r\nparametrises the regular orbits in the Lie algebra of an algebraic group. Before proving\r\nthe main theorem, we also include a historical overview of the field. In particular we bring\r\ntogether the results of Akyildiz, Carrell and Lieberman on non-equivariant cohomology\r\nrings."}],"file":[{"checksum":"1610063569f5452f8a5acef728c2fc26","file_name":"thesis.zip","creator":"krychlew","file_id":"17179","date_updated":"2024-06-26T21:00:14Z","file_size":2761814,"date_created":"2024-06-26T20:56:27Z","content_type":"application/zip","relation":"source_file","access_level":"closed"},{"date_created":"2024-06-26T20:58:24Z","file_size":3695952,"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"17180","creator":"krychlew","date_updated":"2024-06-26T20:58:24Z","file_name":"thesis.pdf","checksum":"7bbadb1fbc9ed2a1ecf54597f88af99c"}],"publication_status":"published","degree_awarded":"PhD","doi":"10.15479/at:ista:17156","oa_version":"Published Version","publication_identifier":{"issn":["2663-337X"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2024-06-23T15:07:06Z","publisher":"Institute of Science and Technology Austria","status":"public","corr_author":"1","page":"117","supervisor":[{"id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9582-2634","first_name":"Tamás","full_name":"Hausel, Tamás","last_name":"Hausel"}],"title":"Equivariant cohomology and rings of functions","_id":"17156","date_published":"2024-06-25T00:00:00Z","alternative_title":["ISTA Thesis"],"date_updated":"2026-04-07T12:55:46Z","language":[{"iso":"eng"}],"ddc":["516"],"year":"2024","month":"06","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"17157"}]}},{"project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020"}],"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"ec_funded":1,"author":[{"full_name":"Reker, Jana","last_name":"Reker","first_name":"Jana","id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9"}],"day":"26","file_date_updated":"2024-06-26T12:44:53Z","OA_place":"publisher","keyword":["Random Matrices","Spectrum","Central Limit Theorem","Resolvent","Free Probability"],"article_processing_charge":"No","type":"dissertation","oa":1,"citation":{"ieee":"J. Reker, “Central limit theorems for random matrices: From resolvents to free probability,” Institute of Science and Technology Austria, 2024.","mla":"Reker, Jana. <i>Central Limit Theorems for Random Matrices: From Resolvents to Free Probability</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:17164\">10.15479/at:ista:17164</a>.","ista":"Reker J. 2024. Central limit theorems for random matrices: From resolvents to free probability. Institute of Science and Technology Austria.","apa":"Reker, J. (2024). <i>Central limit theorems for random matrices: From resolvents to free probability</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:17164\">https://doi.org/10.15479/at:ista:17164</a>","chicago":"Reker, Jana. “Central Limit Theorems for Random Matrices: From Resolvents to Free Probability.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:17164\">https://doi.org/10.15479/at:ista:17164</a>.","ama":"Reker J. Central limit theorems for random matrices: From resolvents to free probability. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:17164\">10.15479/at:ista:17164</a>","short":"J. Reker, Central Limit Theorems for Random Matrices: From Resolvents to Free Probability, Institute of Science and Technology Austria, 2024."},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Institute of Science and Technology Austria","date_created":"2024-06-24T11:23:29Z","degree_awarded":"PhD","doi":"10.15479/at:ista:17164","abstract":[{"text":"This thesis is structured into two parts. In the first part, we consider the random\r\nvariable X := Tr(f1(W)A1 . . . fk(W)Ak) where W is an N × N Hermitian Wigner matrix, k ∈ N, and we choose (possibly N-dependent) regular functions f1, . . . , fk as well as\r\nbounded deterministic matrices A1, . . . , Ak. In this context, we prove a functional central\r\nlimit theorem on macroscopic and mesoscopic scales, showing that the fluctuations of X\r\naround its expectation are Gaussian and that the limiting covariance structure is given\r\nby a deterministic recursion. We further give explicit error bounds in terms of the scaling\r\nof f1, . . . , fk and the number of traceless matrices among A1, . . . , Ak, thus extending\r\nthe results of Cipolloni, Erdős and Schröder [40] to products of arbitrary length k ≥ 2.\r\nAnalyzing the underlying combinatorics leads to a non-recursive formula for the variance\r\nof X as well as the covariance of X and Y := Tr(fk+1(W)Ak+1 . . . fk+ℓ(W)Ak+ℓ) of similar\r\nbuild. When restricted to polynomials, these formulas reproduce recent results of Male,\r\nMingo, Peché, and Speicher [107], showing that the underlying combinatorics of noncrossing partitions and annular non-crossing permutations continue to stay valid beyond\r\nthe setting of second-order free probability theory. As an application, we consider the\r\nfluctuation of Tr(eitW A1e\r\n−itW A2)/N around its thermal value Tr(A1) Tr(A2)/N2 when t\r\nis large and give an explicit formula for the variance.\r\nThe second part of the thesis collects three smaller projects focusing on different random\r\nmatrix models. In the first project, we show that a class of weakly perturbed Hamiltonians\r\nof the form Hλ = H0 + λW, where W is a Wigner matrix, exhibits prethermalization.\r\nThat is, the time evolution generated by Hλ relaxes to its ultimate thermal state via an\r\nintermediate prethermal state with a lifetime of order λ\r\n−2\r\n. As the main result, we obtain\r\na general relaxation formula, expressing the perturbed dynamics via the unperturbed\r\ndynamics and the ultimate thermal state. The proof relies on a two-resolvent global law\r\nfor the deformed Wigner matrix Hλ.\r\nThe second project focuses on correlated random matrices, more precisely on a correlated N × N Hermitian random matrix with a polynomially decaying metric correlation\r\nstructure. A trivial a priori bound shows that the operator norm of this model is stochastically dominated by √\r\nN. However, by calculating the trace of the moments of the matrix\r\nand using the summable decay of the cumulants, the norm estimate can be improved to a\r\nbound of order one.\r\nIn the third project, we consider a multiplicative perturbation of the form UA(t) where U\r\nis a unitary random matrix and A = diag(t, 1, ..., 1). This so-called UA model was\r\nfirst introduced by Fyodorov [73] for its applications in scattering theory. We give a\r\ngeneral description of the eigenvalue trajectories obtained by varying the parameter t and\r\nintroduce a flow of deterministic domains that separates the outlier resulting from the\r\nrank-one perturbation from the typical eigenvalues for all sub-critical timescales. The\r\nresults are obtained under generic assumptions on U that hold for various unitary random\r\nmatrices, including the circular unitary ensemble (CUE) in the original formulation of\r\nthe model.","lang":"eng"}],"file":[{"date_updated":"2024-06-26T12:44:53Z","file_id":"17176","creator":"jreker","file_name":"ISTA_Thesis_JReker.pdf","checksum":"fb16d86e1f2753dc3a9e14d2bdfd84cd","access_level":"open_access","content_type":"application/pdf","relation":"main_file","date_created":"2024-06-26T12:39:36Z","file_size":2783027},{"file_name":"ISTA_Thesis_JReker_SourceFiles.zip","checksum":"cb1e54009d47c1dcf5b866c4566fa27f","date_updated":"2024-06-26T12:44:53Z","file_id":"17177","creator":"jreker","access_level":"closed","content_type":"application/zip","relation":"source_file","date_created":"2024-06-26T12:39:42Z","file_size":3054878}],"publication_status":"published","publication_identifier":{"issn":["2663-337X"]},"oa_version":"Published Version","title":"Central limit theorems for random matrices: From resolvents to free probability","status":"public","supervisor":[{"orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","full_name":"Erdös, László","last_name":"Erdös"}],"corr_author":"1","page":"206","year":"2024","ddc":["519"],"related_material":{"record":[{"status":"public","id":"17173","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"11135"},{"status":"public","id":"17047","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"17154","status":"public"},{"id":"17174","relation":"part_of_dissertation","status":"public"}]},"month":"06","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"alternative_title":["ISTA Thesis"],"_id":"17164","date_published":"2024-06-26T00:00:00Z","date_updated":"2026-04-07T13:02:13Z","language":[{"iso":"eng"}]},{"quality_controlled":"1","date_updated":"2025-04-15T07:16:57Z","language":[{"iso":"eng"}],"date_published":"2024-06-06T00:00:00Z","_id":"17170","alternative_title":["LIPIcs"],"has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"month":"06","conference":{"end_date":"2024-06-14","name":"SoCG: Symposium on Computational Geometry","start_date":"2024-06-11","location":"Athens, Greece"},"year":"2024","ddc":["516"],"page":"11:1-11:19","arxiv":1,"status":"public","volume":293,"title":"Tight bounds for the learning of homotopy à la Niyogi, Smale, and Weinberger for subsets of euclidean spaces and of Riemannian manifolds","oa_version":"Published Version","publication_identifier":{"eissn":["1868-8969"],"isbn":["9783959773164"]},"publication_status":"published","publication":"40th International Symposium on Computational Geometry","abstract":[{"lang":"eng","text":"In this article we extend and strengthen the seminal work by Niyogi, Smale, and Weinberger on the learning of the homotopy type from a sample of an underlying space. In their work, Niyogi, Smale, and Weinberger studied samples of C² manifolds with positive reach embedded in ℝ^d. We extend their results in the following ways: - As the ambient space we consider both ℝ^d and Riemannian manifolds with lower bounded sectional curvature. - In both types of ambient spaces, we study sets of positive reach - a significantly more general setting than C² manifolds - as well as general manifolds of positive reach. - The sample P of a set (or a manifold) 𝒮 of positive reach may be noisy. We work with two one-sided Hausdorff distances - ε and δ - between P and 𝒮. We provide tight bounds in terms of ε and δ, that guarantee that there exists a parameter r such that the union of balls of radius r centred at the sample P deformation-retracts to 𝒮. We exhibit their tightness by an explicit construction. We carefully distinguish the roles of δ and ε. This is not only essential to achieve tight bounds, but also sensible in practical situations, since it allows one to adapt the bound according to sample density and the amount of noise present in the sample separately."}],"file":[{"date_created":"2024-06-25T11:47:26Z","file_size":20886142,"access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_id":"17171","creator":"cfillmor","date_updated":"2024-06-25T11:47:26Z","success":1,"file_name":"LIPIcs.SoCG.2024.11.pdf","checksum":"6a2ddc8b51aa58f197a8b294750f1f8d"}],"doi":"10.4230/LIPIcs.SoCG.2024.11","date_created":"2024-06-25T11:45:58Z","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"D. Attali, H. Kourimska, C.D. Fillmore, I. Ghosh, A. Lieutier, E.R. Stephenson, M. Wintraecken, in:, 40th International Symposium on Computational Geometry, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024, p. 11:1-11:19.","ama":"Attali D, Kourimska H, Fillmore CD, et al. Tight bounds for the learning of homotopy à la Niyogi, Smale, and Weinberger for subsets of euclidean spaces and of Riemannian manifolds. In: <i>40th International Symposium on Computational Geometry</i>. Vol 293. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2024:11:1-11:19. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2024.11\">10.4230/LIPIcs.SoCG.2024.11</a>","chicago":"Attali, Dominique, Hana Kourimska, Christopher D Fillmore, Ishika Ghosh, André Lieutier, Elizabeth R Stephenson, and Mathijs Wintraecken. “Tight Bounds for the Learning of Homotopy à La Niyogi, Smale, and Weinberger for Subsets of Euclidean Spaces and of Riemannian Manifolds.” In <i>40th International Symposium on Computational Geometry</i>, 293:11:1-11:19. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2024.11\">https://doi.org/10.4230/LIPIcs.SoCG.2024.11</a>.","apa":"Attali, D., Kourimska, H., Fillmore, C. D., Ghosh, I., Lieutier, A., Stephenson, E. R., &#38; Wintraecken, M. (2024). Tight bounds for the learning of homotopy à la Niyogi, Smale, and Weinberger for subsets of euclidean spaces and of Riemannian manifolds. In <i>40th International Symposium on Computational Geometry</i> (Vol. 293, p. 11:1-11:19). Athens, Greece: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2024.11\">https://doi.org/10.4230/LIPIcs.SoCG.2024.11</a>","ista":"Attali D, Kourimska H, Fillmore CD, Ghosh I, Lieutier A, Stephenson ER, Wintraecken M. 2024. Tight bounds for the learning of homotopy à la Niyogi, Smale, and Weinberger for subsets of euclidean spaces and of Riemannian manifolds. 40th International Symposium on Computational Geometry. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 293, 11:1-11:19.","mla":"Attali, Dominique, et al. “Tight Bounds for the Learning of Homotopy à La Niyogi, Smale, and Weinberger for Subsets of Euclidean Spaces and of Riemannian Manifolds.” <i>40th International Symposium on Computational Geometry</i>, vol. 293, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024, p. 11:1-11:19, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2024.11\">10.4230/LIPIcs.SoCG.2024.11</a>.","ieee":"D. Attali <i>et al.</i>, “Tight bounds for the learning of homotopy à la Niyogi, Smale, and Weinberger for subsets of euclidean spaces and of Riemannian manifolds,” in <i>40th International Symposium on Computational Geometry</i>, Athens, Greece, 2024, vol. 293, p. 11:1-11:19."},"oa":1,"type":"conference","article_processing_charge":"No","intvolume":"       293","file_date_updated":"2024-06-25T11:47:26Z","day":"06","author":[{"last_name":"Attali","full_name":"Attali, Dominique","first_name":"Dominique"},{"orcid":"0000-0001-7841-0091","first_name":"Hana","id":"D9B8E14C-3C26-11EA-98F5-1F833DDC885E","full_name":"Kourimska, Hana","last_name":"Kourimska"},{"last_name":"Fillmore","full_name":"Fillmore, Christopher D","first_name":"Christopher D","id":"35638A5C-AAC7-11E9-B0BF-5503E6697425"},{"full_name":"Ghosh, Ishika","last_name":"Ghosh","id":"ee449b28-344d-11ef-a6d5-9ca430e9e9ff","first_name":"Ishika"},{"full_name":"Lieutier, André","last_name":"Lieutier","first_name":"André"},{"full_name":"Stephenson, Elizabeth R","last_name":"Stephenson","orcid":"0000-0002-6862-208X","id":"2D04F932-F248-11E8-B48F-1D18A9856A87","first_name":"Elizabeth R"},{"full_name":"Wintraecken, Mathijs","last_name":"Wintraecken","first_name":"Mathijs","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7472-2220"}],"external_id":{"arxiv":["2206.10485"]},"scopus_import":"1","ec_funded":1,"department":[{"_id":"GradSch"},{"_id":"HeEd"}],"acknowledgement":"This research has been supported by the European Research Council (ERC), grant No. 788183, by the Wittgenstein Prize, Austrian Science Fund (FWF), grant No. Z 342-N31, and by the DFG Collaborative Research Center TRR 109, Austrian Science Fund (FWF), grant No. I 02979-N35.\r\nWintraecken, Mathijs: Supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411, the Austrian science fund (FWF) grant No. M-3073, and the welcome package from IDEX of the Université Côte d'Azur.","project":[{"call_identifier":"H2020","name":"Alpha Shape Theory Extended","grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Mathematics, Computer Science","_id":"268116B8-B435-11E9-9278-68D0E5697425","grant_number":"Z00342"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes","grant_number":"I02979-N35"},{"_id":"fc390959-9c52-11eb-aca3-afa58bd282b2","grant_number":"M03073","name":"Learning and triangulating manifolds via collapses"}]}]