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Rella, Adaptive Processes in Biology and Culture: Models of Evolving Vaccine Resistance and the Record Statistics of Innovation, Institute of Science and Technology Austria, 2025.","chicago":"Rella, Simon. “Adaptive Processes in Biology and Culture: Models of Evolving Vaccine Resistance and the Record Statistics of Innovation.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20811\">https://doi.org/10.15479/AT-ISTA-20811</a>.","ista":"Rella S. 2025. Adaptive processes in biology and culture: Models of evolving vaccine resistance and the record statistics of innovation. Institute of Science and Technology Austria.","ieee":"S. Rella, “Adaptive processes in biology and culture: Models of evolving vaccine resistance and the record statistics of innovation,” Institute of Science and Technology Austria, 2025.","mla":"Rella, Simon. <i>Adaptive Processes in Biology and Culture: Models of Evolving Vaccine Resistance and the Record Statistics of Innovation</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20811\">10.15479/AT-ISTA-20811</a>.","ama":"Rella S. Adaptive processes in biology and culture: Models of evolving vaccine resistance and the record statistics of innovation. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20811\">10.15479/AT-ISTA-20811</a>","apa":"Rella, S. (2025). <i>Adaptive processes in biology and culture: Models of evolving vaccine resistance and the record statistics of innovation</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20811\">https://doi.org/10.15479/AT-ISTA-20811</a>"},"author":[{"full_name":"Rella, Simon","first_name":"Simon","id":"B4765ACA-AA38-11E9-AC9A-0930E6697425","last_name":"Rella"}],"date_updated":"2026-10-02T10:12:19Z","doi_confirm":"1","has_accepted_license":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","status":"public","fulldoi":"https://doi.org/10.15479/AT-ISTA-20811","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","year":"2025","type":"dissertation","day":"15","abstract":[{"text":"\tThis thesis is organized into two parts, each comprising two chapters: Chapter 1 and 2 offer models for the evolution of vaccine resistance in response to diverse vaccination strategies. Chapter 3 and 4 review the statistics of records, their connection to models of innovation and an application to the cultural evolution of sports.\r\n\tIn chapter 1 we present a modelling study from 2021 on the evolution of SARS-CoV-2. At that time the vaccine-resistant Omicron variant had not yet evolved. In our model we consider a population that is becoming vaccinated over time, while a pathogen is spreading in the population and eventually becoming resistant to the vaccine. We explore effective pharmaceutical and non-pharmaceutical interventions to prevent the emergence of vaccine resistance. \r\n\tIn chapter 2 we model a particular set of complex vaccination strategies, mosaic and pyramid vaccination, where an immunologically diverse portfolio of vaccines is considered. We find that a bet-hatching strategy, in which vaccine types are distributed in the population, is effective at hindering the evolution of vaccine resistance if mutation rates are high. \r\n\tIn chapter 3 we switch gears and present a review on the statistics of records. We highlight similarities and analogies to other models in the fields of statistical physics, evolution and innovation. This offers interesting complimentary perspectives on well-known models. \r\n\tIn chapter 4 we apply models of record statistics and innovation to study cultural evolution in sport. We propose a model of sport evolution that combines deterministic improvements in performance and stochastic bursts of improvements due to innovation. ","lang":"eng"}],"doi":"10.15479/AT-ISTA-20811","_id":"20811","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication_status":"published","alternative_title":["ISTA Thesis"],"oa":1,"file":[{"file_name":"2025_Rella_Simon_Thesis.pdf","file_size":29019662,"access_level":"open_access","date_created":"2025-12-16T21:49:52Z","file_id":"20831","content_type":"application/pdf","success":1,"creator":"srella","checksum":"a0bd7a585720e60df284101b8afdf6bb","relation":"main_file","date_updated":"2025-12-16T21:49:52Z"},{"file_id":"20832","content_type":"application/zip","creator":"srella","date_updated":"2025-12-16T21:52:19Z","relation":"source_file","checksum":"b8b3a90932ae1d96d307838710f46e32","file_name":"2025_Rella_Simon_Thesis_Sourcefiles.zip","file_size":42094025,"access_level":"open_access","date_created":"2025-12-16T21:52:19Z"}]},{"abstract":[{"text":"Research Data for publication 'Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors'","lang":"eng"}],"doi":"10.15479/AT:ISTA:18886","project":[{"_id":"34c0acea-11ca-11ed-8bc3-8775e10fd452","name":"Integrated Germanium Quantum Technology","grant_number":"101069515"},{"call_identifier":"FWF","grant_number":"P32235","name":"Towards scalable hut wire quantum devices","_id":"237B3DA4-32DE-11EA-91FC-C7463DDC885E"},{"_id":"bd8bd29e-d553-11ed-ba76-f0070d4b237a","name":"Merging spin and superconducting qubits in planar Ge","grant_number":"P36507"},{"_id":"c0977eea-5a5b-11eb-8a69-a862db0cf4d1","grant_number":"I05060","name":"High impedance circuit quantum electrodynamics with hole spins"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"_id":"18886","file":[{"content_type":"text/plain","file_id":"18893","success":1,"creator":"arashid","date_updated":"2025-01-27T11:27:30Z","relation":"main_file","checksum":"977dffed4bec3c7d6315aa1cbd19e8a7","file_name":"readme.txt","file_size":1017,"access_level":"open_access","date_created":"2025-01-27T11:27:30Z"},{"file_size":33815056,"access_level":"open_access","file_name":"research_data.zip","date_created":"2025-01-27T11:27:35Z","success":1,"file_id":"18894","content_type":"application/zip","date_updated":"2025-01-27T11:27:35Z","checksum":"7ab5e3e65ddf59bbf3622ace8a0cda1c","relation":"main_file","creator":"arashid"}],"oa":1,"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:18886","OA_type":"gold","status":"public","type":"research_data","year":"2025","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","day":"27","month":"01","related_material":{"record":[{"relation":"used_in_publication","id":"19401","status":"public"},{"status":"public","id":"18144","relation":"used_in_publication"}]},"date_published":"2025-01-27T00:00:00Z","ddc":["530"],"OA_place":"repository","citation":{"apa":"Janik, M. (2025). Research data for publication “Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18886\">https://doi.org/10.15479/AT:ISTA:18886</a>","ama":"Janik M. Research data for publication “Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors.” 2025. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18886\">10.15479/AT:ISTA:18886</a>","mla":"Janik, Marian. <i>Research Data for Publication “Strong Charge-Photon Coupling in Planar Germanium Enabled by Granular Aluminium Superinductors.”</i> Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18886\">10.15479/AT:ISTA:18886</a>.","ieee":"M. Janik, “Research data for publication ‘Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors.’” Institute of Science and Technology Austria, 2025.","ista":"Janik M. 2025. Research data for publication ‘Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:18886\">10.15479/AT:ISTA:18886</a>.","chicago":"Janik, Marian. “Research Data for Publication ‘Strong Charge-Photon Coupling in Planar Germanium Enabled by Granular Aluminium Superinductors.’” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT:ISTA:18886\">https://doi.org/10.15479/AT:ISTA:18886</a>.","short":"M. Janik, (2025)."},"author":[{"last_name":"Janik","id":"396A1950-F248-11E8-B48F-1D18A9856A87","full_name":"Janik, Marian","first_name":"Marian","orcid":"0009-0003-9037-8831"}],"date_updated":"2026-10-02T11:05:09Z","file_date_updated":"2025-01-27T11:27:35Z","department":[{"_id":"GeKa"},{"_id":"GradSch"}],"title":"Research data for publication 'Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors'","article_processing_charge":"No","date_created":"2025-01-27T09:48:44Z","corr_author":"1","acknowledgement":"We acknowledge Franco De Palma, Mahya Khorramshahi, Fabian Oppliger, Thomas Reisinger, Pasquale Scarlino and Xiao Xue for helpful discussions. We thank Simon Robson for proofreading the manuscript. This research was supported by the Scientific Service Units of ISTA through resources provided by the MIBA Machine Shop and the Nanofabrication facility. This research and related results were made possible with the support of the NOMIS Foundation and the HORIZON-RIA 101069515 project. This research was funded in whole or in part by the Austrian Science Fund (FWF) DOI:10.55776/P32235, DOI:10.55776/I5060 and DOI:10.55776/P36507. For Open Access purposes, the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission. M.J. acknowledges funding from FellowQUTE 2024-01. I.M.P. acknowledges funding from the Deutsche Forschungsgemeinschaft (DFG – German Research Foundation) under project number 450396347 (GeHoldeQED). ICN2 acknowledges funding from Generalitat de Catalunya 2021SGR00457. We acknowledge support from CSIC Interdisciplinary Thematic Platform (PTI+) on Quantum Technologies (PTI-QTEP+). This research work has been funded by the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC's Quantum Technologies Platform (QTEP). ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI (Grant No.: CEX2021-001214-S) and is funded by the CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science PhD program. AGM has received funding from Grant RYC2021-033479-I funded by MCIN/AEI/10.13039/501100011033 and by European Union NextGenerationEU/PRTR. M.B. acknowledges support from SUR Generalitat de Catalunya and the EU Social Fund; project ref. 2020 FI 00103. The authors acknowledge the use of instrumentation and the technical advice provided by the Joint Electron Microscopy Center at ALBA (JEMCA). ICN2 acknowledges funding from Grant IU16-014206 (METCAM-FIB) funded by the European Union through the European Regional Development Fund (ERDF), with the support of the Ministry of Research and Universities, Generalitat de Catalunya. ICN2 is a founding member of e-DREAM.","contributor":[{"id":"53f93ea2-803f-11ed-ab7e-b283135794ef","first_name":"Kevin Etienne Robert","contributor_type":"researcher","last_name":"Roux"},{"last_name":"Borja Espinosa","contributor_type":"researcher","first_name":"Carla N","id":"18777c01-896a-11ed-bdf8-e4851dc07d16"},{"contributor_type":"researcher","id":"71616374-A8E9-11E9-A7CA-09ECE5697425","first_name":"Oliver","last_name":"Sagi"},{"contributor_type":"researcher","id":"160D87FA-96B5-11E9-BF77-7626E6697425","first_name":"Abdulhamid","last_name":"Baghdadi"},{"last_name":"Adletzberger","first_name":"Thomas","id":"38756BB2-F248-11E8-B48F-1D18A9856A87","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"Stefano","last_name":"Calcaterra"},{"first_name":"Marc","contributor_type":"researcher","last_name":"Botifoll"},{"first_name":"Alba Garzón","contributor_type":"researcher","last_name":"Manjón"},{"last_name":"Arbiol","contributor_type":"researcher","first_name":"Jordi"},{"last_name":"Chrastina","first_name":"Daniel","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"Giovanni","last_name":"Isella"},{"last_name":"Pop","contributor_type":"researcher","first_name":"Ioan M."},{"last_name":"Katsaros","contributor_type":"researcher","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios"}]},{"citation":{"ieee":"M. Bhargava, “Design and control of deformable structures: From PCB lighting displays to elastomer robots,” Institute of Science and Technology Austria, 2025.","ista":"Bhargava M. 2025. Design and control of deformable structures: From PCB lighting displays to elastomer robots. Institute of Science and Technology Austria.","chicago":"Bhargava, Manas. “Design and Control of Deformable Structures: From PCB Lighting Displays to Elastomer Robots.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20276\">https://doi.org/10.15479/AT-ISTA-20276</a>.","short":"M. Bhargava, Design and Control of Deformable Structures: From PCB Lighting Displays to Elastomer Robots, Institute of Science and Technology Austria, 2025.","apa":"Bhargava, M. (2025). <i>Design and control of deformable structures: From PCB lighting displays to elastomer robots</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20276\">https://doi.org/10.15479/AT-ISTA-20276</a>","mla":"Bhargava, Manas. <i>Design and Control of Deformable Structures: From PCB Lighting Displays to Elastomer Robots</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20276\">10.15479/AT-ISTA-20276</a>.","ama":"Bhargava M. Design and control of deformable structures: From PCB lighting displays to elastomer robots. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20276\">10.15479/AT-ISTA-20276</a>"},"OA_place":"publisher","date_updated":"2026-10-02T11:13:08Z","doi_confirm":"1","author":[{"orcid":"0009-0007-6138-6890","first_name":"Manas","full_name":"Bhargava, Manas","id":"FF8FA64C-AA6A-11E9-99AD-50D4E5697425","last_name":"Bhargava"}],"month":"09","related_material":{"record":[{"relation":"part_of_dissertation","id":"13049","status":"public"},{"id":"20286","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"18565"}]},"page":"96","degree_awarded":"PhD","date_published":"2025-09-02T00:00:00Z","ddc":["000"],"acknowledgement":"Financial support was provided by the European Research Council (ERC) under grant agreement No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented Computational Design\r\nand Modeling that I gratefully acknowledge.\r\n","corr_author":"1","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-065-7"]},"file_date_updated":"2025-09-04T09:22:29Z","department":[{"_id":"GradSch"},{"_id":"BeBi"}],"article_processing_charge":"No","title":"Design and control of deformable structures: From PCB lighting displays to elastomer robots","date_created":"2025-09-02T14:48:39Z","supervisor":[{"last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd","full_name":"Bickel, Bernd","orcid":"0000-0001-6511-9385"}],"language":[{"iso":"eng"}],"file":[{"success":1,"content_type":"application/pdf","file_id":"20284","relation":"main_file","checksum":"5baf8ca46c86a94fc8380ff1007aabd4","date_updated":"2025-09-03T10:40:52Z","creator":"mbhargav","file_size":161436245,"access_level":"open_access","file_name":"2025-Bhargava-Manas-Thesis.pdf","date_created":"2025-09-03T10:40:52Z"},{"content_type":"application/x-zip-compressed","file_id":"20285","creator":"mbhargav","relation":"source_file","checksum":"66878fafbc0074f88ddd18f24a9fc647","date_updated":"2025-09-04T09:22:29Z","file_name":"manas_phd_thesis_source_files.zip","file_size":198831315,"access_level":"closed","date_created":"2025-09-03T13:18:05Z"}],"alternative_title":["ISTA Thesis"],"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"_id":"20276","publication_status":"published","abstract":[{"lang":"eng","text":"Complex 3D shapes can be created by morphing flat 2D configurations. Such deformations\r\neither preserve the intrinsic material geometry (e.g., folding paper) or modify it through\r\nlocalized contraction. Once transformed, the 3D shape can be further controlled to achieve a\r\ntarget functionality. A key challenge is to take the material specifications and the actuation\r\nprocess as input to automatically design the target 3D shape and its functionality. This thesis\r\npresents two novel computational pipelines for the design and control of shape-morphing\r\nstructures used to create functional prototypes.\r\nThe first pipeline borrows from the art of origami to fold paper into intricate shapes and\r\napplies this principle to make 3D lighting displays. We introduce, PCBend a computational\r\ndesign approach that covers a surface with individually addressable RGB LEDs, effectively\r\nforming a low-resolution surface by folding rigid printed circuit boards (PCBs). We optimize\r\ncut patterns on PCBs to act as hinges and co-design LED placement, circuit routing, and\r\nfabrication constraints to produce PCB blueprints. The PCBs are fabricated using automated\r\nstandard manufacturing services with LEDs embedded on them. Finally, the fabricated PCBs\r\nare cut along the contour and folded onto a 3D-printed support. The 3D lighting display is\r\nthen controlled to display complex surface light patterns.\r\nCreating 3D shapes through folding is only possible if their planar configuration, called ”unfolding” exists without any distortion or overlap. Existing methods often permit distortion\r\nor require multiple patches, which are unsuitable for fabrication pipelines that rely on folding\r\nnon-stretchable materials. We reinforce such fabrication pipelines by providing a geometric\r\nrelaxation to the problem, where the input shape is modified to admit overlap-free unfolding.\r\nThe second fabrication pipeline extends shape morphing to soft robotics by emulating nature’s\r\nblueprint of distributed actuation. Inspired by vertebrates, we build musculoskeletal robots\r\nusing modular active actuators, employing Liquid Crystal Elastomers (LCEs) as shrinkable\r\nartificial muscles integrated with 3D-printed bones. The chemical composition of LCEs is\r\naltered to enable untethered actuation through infrared radiation, allowing active control of\r\nindividual muscles and their corresponding bones. The combined motion of individual bones\r\ndefines the robot’s overall shape and functionality. Our proposed system significantly expands\r\nboth the design and control spaces of soft robots, which we harness using our computational\r\ndesign tools. We build several physical robots that exhibit complex shape morphing and varied\r\nterrain navigation, showcasing the versatility of our pipeline.\r\nThis thesis explores applications ranging from intricate light patterns displayed on 3D shapes\r\nformed by folding rigid PCBs to untethered robots that use contractile muscles to exhibit\r\nshape morphing and locomotion. Through these examples, the thesis highlights how computational design and distributed actuation, integrated with novel materials, can transform\r\npassive structures into functional prototypes."}],"doi":"10.15479/AT-ISTA-20276","project":[{"_id":"24F9549A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"715767","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-20276","status":"public","day":"02","ec_funded":1,"type":"dissertation","year":"2025","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","has_accepted_license":"1"},{"doi":"10.1111/cgf.15269","abstract":[{"text":"We present a computational approach for unfolding 3D shapes isometrically into the plane as a single patch without overlapping triangles. This is a hard, sometimes impossible, problem, which existing methods are forced to soften by allowing for map distortions or multiple patches. Instead, we propose a geometric relaxation of the problem: We modify the input shape until it admits an overlap‐free unfolding. We achieve this by locally displacing vertices and collapsing edges, guided by the unfolding process. We validate our algorithm quantitatively and qualitatively on a large dataset of complex shapes and show its proficiency by fabricating real shapes from paper.","lang":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"_id":"18565","publication_status":"published","publication":"Computer Graphics Forum","oa":1,"file":[{"creator":"mbhargav","date_updated":"2024-11-19T09:23:20Z","relation":"main_file","checksum":"34acdd9bfbe43f00eb6c7656afef3ac6","file_id":"18567","content_type":"video/mp4","success":1,"date_created":"2024-11-19T09:23:20Z","file_name":"Mesh_Simplification_For_Unfolding_cgf_submission_supplemental_video.mp4","file_size":36999751,"access_level":"open_access"},{"date_created":"2025-04-16T09:06:45Z","file_name":"2025_CompGraphicsForum_Bhargava.pdf","access_level":"open_access","file_size":5188265,"creator":"dernst","relation":"main_file","checksum":"efb06b01bae37f470954601bc004374d","date_updated":"2025-04-16T09:06:45Z","file_id":"19576","content_type":"application/pdf","success":1}],"quality_controlled":"1","volume":44,"isi":1,"has_accepted_license":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","intvolume":"        44","OA_type":"hybrid","status":"public","fulldoi":"https://doi.org/10.1111/cgf.15269","article_number":"e15269","oa_version":"Published Version","publisher":"Wiley","year":"2025","type":"journal_article","day":"01","researchdata_availability":"no","das_tickbox":"0","month":"02","related_material":{"record":[{"id":"20276","status":"public","relation":"dissertation_contains"}]},"ddc":["006"],"date_published":"2025-02-01T00:00:00Z","arxiv":1,"OA_place":"publisher","issue":"1","citation":{"apa":"Bhargava, M., Schreck, C., Freire, M., Hugron, P. A., Lefebvre, S., Sellán, S., &#38; Bickel, B. (2025). Mesh simplification for unfolding. <i>Computer Graphics Forum</i>. Wiley. <a href=\"https://doi.org/10.1111/cgf.15269\">https://doi.org/10.1111/cgf.15269</a>","mla":"Bhargava, Manas, et al. “Mesh Simplification for Unfolding.” <i>Computer Graphics Forum</i>, vol. 44, no. 1, e15269, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/cgf.15269\">10.1111/cgf.15269</a>.","ama":"Bhargava M, Schreck C, Freire M, et al. Mesh simplification for unfolding. <i>Computer Graphics Forum</i>. 2025;44(1). doi:<a href=\"https://doi.org/10.1111/cgf.15269\">10.1111/cgf.15269</a>","ieee":"M. Bhargava <i>et al.</i>, “Mesh simplification for unfolding,” <i>Computer Graphics Forum</i>, vol. 44, no. 1. Wiley, 2025.","ista":"Bhargava M, Schreck C, Freire M, Hugron PA, Lefebvre S, Sellán S, Bickel B. 2025. Mesh simplification for unfolding. Computer Graphics Forum. 44(1), e15269.","chicago":"Bhargava, Manas, Camille Schreck, M. Freire, P. A. Hugron, S. Lefebvre, S. Sellán, and Bernd Bickel. “Mesh Simplification for Unfolding.” <i>Computer Graphics Forum</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/cgf.15269\">https://doi.org/10.1111/cgf.15269</a>.","short":"M. Bhargava, C. Schreck, M. Freire, P.A. Hugron, S. Lefebvre, S. Sellán, B. Bickel, Computer Graphics Forum 44 (2025)."},"supplementarymaterial":"yes","author":[{"orcid":"0009-0007-6138-6890","full_name":"Bhargava, Manas","first_name":"Manas","id":"FF8FA64C-AA6A-11E9-99AD-50D4E5697425","last_name":"Bhargava"},{"last_name":"Schreck","id":"2B14B676-F248-11E8-B48F-1D18A9856A87","first_name":"Camille","full_name":"Schreck, Camille"},{"last_name":"Freire","first_name":"M.","full_name":"Freire, M."},{"first_name":"P. A.","full_name":"Hugron, P. A.","last_name":"Hugron"},{"last_name":"Lefebvre","first_name":"S.","full_name":"Lefebvre, S."},{"full_name":"Sellán, S.","first_name":"S.","last_name":"Sellán"},{"last_name":"Bickel","full_name":"Bickel, Bernd","first_name":"Bernd","id":"49876194-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6511-9385"}],"date_updated":"2026-10-02T11:13:08Z","article_processing_charge":"Yes (via OA deal)","title":"Mesh simplification for unfolding","file_date_updated":"2025-04-16T09:06:45Z","department":[{"_id":"GradSch"},{"_id":"BeBi"}],"scopus_import":"1","publication_identifier":{"issn":["0167-7055"],"eissn":["1467-8659"]},"keyword":["fabrication","single patch unfolding","mesh simplification"],"language":[{"iso":"eng"}],"date_created":"2024-11-19T09:14:32Z","article_type":"original","corr_author":"1","external_id":{"isi":["001357046100001"],"arxiv":["2408.06944"]},"acknowledgement":"Researchers from INRIA received support from the DORNELL Inria Challenge. Silvia Sellán acknowledges support from NSERC Vanier Doctoral Scholarship and an MIT SoE Postdoctoral Fellowship for Engineering Excellence."},{"publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","year":"2025","type":"dissertation","day":"30","status":"public","fulldoi":"https://doi.org/10.15479/10.15479/at-ista-19759","has_accepted_license":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher_comment":"In reference to IEEE copyrighted material which is used with permission in this thesis, the IEEE does not\r\nendorse any of ISTA's products or services. Internal or personal use of this\r\nmaterial is permitted. If interested in reprinting/republishing IEEE copyrighted material for advertising or promotional\r\npurposes or for creating new collective works for resale or redistribution, please go to\r\nhttp://www.ieee.org/publications_standards/publications/rights/rights_link.html to learn how to obtain a License from\r\nRightsLink.  If applicable, University Microfilms and/or ProQuest Library, or the Archives of Canada may supply single copies of the dissertation.","oa":1,"alternative_title":["ISTA Thesis"],"file":[{"file_id":"19829","content_type":"application/pdf","relation":"main_file","checksum":"e5108e759014e2a9020c973c778fafc9","date_updated":"2025-06-10T18:11:05Z","creator":"bprach","file_size":3578077,"access_level":"open_access","file_name":"ThesisFinal.pdf","date_created":"2025-06-10T18:11:05Z"},{"content_type":"application/x-zip-compressed","file_id":"19830","date_updated":"2025-06-10T18:14:03Z","relation":"source_file","checksum":"51bf6c11fb6d8a9f8010b458c600a83f","creator":"bprach","file_size":74894357,"access_level":"closed","file_name":"ThesisFinal.zip","date_created":"2025-06-10T18:14:03Z"}],"doi":"10.15479/10.15479/at-ista-19759","abstract":[{"lang":"eng","text":"Despite generating remarkable results in various computer vision tasks, deep learning comes\r\nwith some surprising shortcomings. For example, tiny perturbations, often imperceptible to\r\nthe human eye, can completely change the predictions of image classifiers. Despite a decade\r\nof research, the field has made limited progress in developing image classifiers that are both\r\naccurate and robust. This thesis aims to address this gap.\r\nAs our first contribution, we aim to simplify the process of training certifiably robust image\r\nclassifiers. We do this by designing a convolutional layer that does not require executing an\r\niterative procedure in every forward pass, but relies on an explicit bound instead. We also\r\npropose a loss function that allows optimizing for a particular margin more precisely.\r\nNext, we provide an overview and comparison of various methods that create robust image\r\nclassifiers by constraining the Lipschitz constant. This is important since generally longer\r\ntraining times and more parameters improve the performance of robust classifiers, making it\r\nchallenging to determine the most practical and effective methods from existing literature.\r\nIn 1-Lipschitz classification, the performance of current methods is still much worse than what\r\nwe expect on the simple tasks we consider. Therefore, we next investigate potential causes of\r\nthis shortcoming. We first consider the role of the activation function. We prove a theoretical\r\nshortcoming of the commonly used activation function, and provide an alternative without it.\r\nHowever this theoretical improvement does barely translate to the empirical performance of\r\nrobust classifiers, suggesting a different bottleneck.\r\nTherefore, in the final chapter, we study how the performance depends on the amount of\r\ntraining data. We prove that in the worst case, we might require far more data to train a\r\nrobust classifier compared to a normal one. We furthermore find that the amount of training\r\ndata is a key determinant of the performance current methods achieve on popular datasets.\r\nAdditionally, we show that linear subspaces exist with tiny data variance, and yet we can\r\nstill train very accurate classifiers after projecting into those subspaces. This shows that on\r\nthe datasets considered, enforcing robustness in classification makes the task strictly more\r\nchallenging.\r\n\r\n"}],"publication_status":"published","_id":"19759","corr_author":"1","supervisor":[{"last_name":"Lampert","orcid":"0000-0001-8622-7887","first_name":"Christoph","full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"language":[{"iso":"eng"}],"date_created":"2025-05-28T16:20:48Z","article_processing_charge":"No","title":"Robust image classification with 1-Lipschitz networks","department":[{"_id":"GradSch"},{"_id":"ChLa"}],"file_date_updated":"2025-06-10T18:14:03Z","publication_identifier":{"issn":["2663-337X"]},"author":[{"first_name":"Bernd","id":"2D561D42-C427-11E9-89B4-9C1AE6697425","full_name":"Prach, Bernd","last_name":"Prach"}],"doi_confirm":"1","date_updated":"2026-10-02T11:16:04Z","OA_place":"publisher","citation":{"mla":"Prach, Bernd. <i>Robust Image Classification with 1-Lipschitz Networks</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/10.15479/at-ista-19759\">10.15479/10.15479/at-ista-19759</a>.","ama":"Prach B. Robust image classification with 1-Lipschitz networks. 2025. doi:<a href=\"https://doi.org/10.15479/10.15479/at-ista-19759\">10.15479/10.15479/at-ista-19759</a>","apa":"Prach, B. (2025). <i>Robust image classification with 1-Lipschitz networks</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/10.15479/at-ista-19759\">https://doi.org/10.15479/10.15479/at-ista-19759</a>","short":"B. Prach, Robust Image Classification with 1-Lipschitz Networks, Institute of Science and Technology Austria, 2025.","ista":"Prach B. 2025. Robust image classification with 1-Lipschitz networks. Institute of Science and Technology Austria.","chicago":"Prach, Bernd. “Robust Image Classification with 1-Lipschitz Networks.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/10.15479/at-ista-19759\">https://doi.org/10.15479/10.15479/at-ista-19759</a>.","ieee":"B. Prach, “Robust image classification with 1-Lipschitz networks,” Institute of Science and Technology Austria, 2025."},"ddc":["000"],"date_published":"2025-05-30T00:00:00Z","degree_awarded":"PhD","page":"84","related_material":{"record":[{"relation":"part_of_dissertation","id":"15039","status":"public"},{"id":"11839","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"18874","status":"public"},{"status":"public","id":"17426","relation":"part_of_dissertation"}]},"month":"05"},{"author":[{"last_name":"Synak","first_name":"Peter","full_name":"Synak, Peter","id":"331776E2-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2026-10-02T11:19:03Z","OA_place":"publisher","citation":{"ieee":"P. Synak, “Methods for fluid simulation, surface tracking, and statistics of non-manifold structures,” Institute of Science and Technology Austria, 2025.","ista":"Synak P. 2025. Methods for fluid simulation, surface tracking, and statistics of non-manifold structures. Institute of Science and Technology Austria.","chicago":"Synak, Peter. “Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19630\">https://doi.org/10.15479/AT-ISTA-19630</a>.","short":"P. Synak, Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures, Institute of Science and Technology Austria, 2025.","apa":"Synak, P. (2025). <i>Methods for fluid simulation, surface tracking, and statistics of non-manifold structures</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19630\">https://doi.org/10.15479/AT-ISTA-19630</a>","mla":"Synak, Peter. <i>Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19630\">10.15479/AT-ISTA-19630</a>.","ama":"Synak P. Methods for fluid simulation, surface tracking, and statistics of non-manifold structures. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19630\">10.15479/AT-ISTA-19630</a>"},"ddc":["519","006"],"date_published":"2025-04-29T00:00:00Z","degree_awarded":"PhD","page":"106","related_material":{"record":[{"id":"8135","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"8384","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"17219","status":"public"}]},"month":"04","corr_author":"1","acknowledgement":"The project in Chapter 2 has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No. 638176. The project in Chapter 3 was funded in part by the European Union (ERC-2021-COG 101045083 CoDiNA). The project in Chapter 4 has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreements No 78818 Alpha and No 638176). It was also partially supported by the DFG Collaborative Research Center TRR 109, 'Discretization in Geometry and Dynamics', through grant no. I02979-N35 of the Austrian Science Fund (FWF). Thank you for providing funds to support my work.","supervisor":[{"last_name":"Wojtan","full_name":"Wojtan, Christopher J","first_name":"Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6646-5546"}],"language":[{"iso":"eng"}],"date_created":"2025-04-29T09:39:34Z","article_processing_charge":"No","title":"Methods for fluid simulation, surface tracking, and statistics of non-manifold structures","file_date_updated":"2025-04-30T15:49:16Z","department":[{"_id":"ChWo"},{"_id":"GradSch"}],"publication_identifier":{"issn":["2663-337X"]},"alternative_title":["ISTA Thesis"],"oa":1,"file":[{"creator":"cchlebak","date_updated":"2025-04-30T14:02:25Z","relation":"source_file","checksum":"f00b519c27529daa0c3b2d4102b4fa7b","file_id":"19633","content_type":"application/x-zip-compressed","date_created":"2025-04-30T14:02:25Z","file_name":"Thesis_source_Heiss_Synak.zip","access_level":"closed","file_size":60670543},{"file_name":"Thesis_PDFA_Heiss_Synak.pdf","access_level":"open_access","file_size":21319043,"date_created":"2025-04-30T14:02:42Z","content_type":"application/pdf","file_id":"19634","creator":"cchlebak","date_updated":"2025-04-30T15:49:16Z","relation":"main_file","checksum":"6e40a2fd3b1b881af1385670854a682e"}],"project":[{"call_identifier":"H2020","grant_number":"638176","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","_id":"2533E772-B435-11E9-9278-68D0E5697425"},{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","grant_number":"101045083","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"},{"_id":"266A2E9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"788183","name":"Alpha Shape Theory Extended"},{"_id":"2533E772-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"638176","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales"},{"name":"Persistence and stability of geometric complexes","grant_number":"I02979-N35","call_identifier":"FWF","_id":"2561EBF4-B435-11E9-9278-68D0E5697425"}],"doi":"10.15479/AT-ISTA-19630","abstract":[{"lang":"eng","text":"This thesis consists of three chapters, each corresponding to one publication. While each of these projects tackles a topic in a different area of research, they all share a common thread in the type of topological structure they handle - a partition of space into volumes separated by interfaces that meet in non-manifold junctions.\r\n\r\nIn Chapter 2, we study clusters of soap bubbles from a simulation perspective. In particular, we develop a surface-only algorithm that couples large scale motion and shape deformation of soap bubble clusters with the small scale evolution of the thin film's thickness, which is responsible for visual phenomena like surface vortices, Newton's interference patterns, capillary waves, and deformation-dependent rupturing of films in a foam. We model film thickness as a reduced degree of freedom in the Navier-Stokes equations and from them derive three sets of equations governing normal and tangential motion of the soap film surface, as well as the evolution of the thin film thickness. We discretize these equations on a non-manifold triangle mesh, extending and adapting operators to handle complex topology. We also present an incompressible fluid solver for 2.5D films and an advection algorithm for convecting fields across non-manifold surface junctions. Our simulations enhance bubble solvers with additional effects caused by convection, rippling, draining, and evaporation of the thin film.\r\n\r\nIn Chapter 3, we introduce a multi-material non-manifold mesh-based surface tracking algorithm that converts mesh defects, such as overlaps, self-intersections, and inversions into topological changes. Our algorithm generalizes prior work on manifold surface tracking with topological changes: it preserves surface features like mesh-based methods, and it robustly handles topological changes like level set methods. Our method also offers improved efficiency and robustness over the state of the art. We demonstrate the effectiveness of the approach on a range of examples, including complex soap film simulations, such as those presented in Chapter 2, but with an order of magnitude more interacting bubbles than what we could achieve before, and Boolean unions of non-manifold meshes consisting of millions of triangles.\r\n\r\nLastly, in Chapter 4, we utilize developments in the theory of random geometric complexes facilitated by observations from Discrete Morse theory. We survey the methods and results obtained with this new approach, and discuss some of its shortcomings. We use simulations to illustrate the results and to form conjectures, getting numerical estimates for combinatorial, topological, and geometric properties of weighted and unweighted Delaunay mosaics, their dual Voronoi tessellations, and the Alpha and Wrap complexes contained in the mosaics."}],"publication_status":"published","_id":"19630","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","ec_funded":1,"type":"dissertation","year":"2025","day":"29","status":"public","fulldoi":"https://doi.org/10.15479/AT-ISTA-19630","has_accepted_license":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"ScienComp"}]},{"fulldoi":"https://doi.org/10.15479/AT-ISTA-20551","status":"public","day":"31","type":"dissertation","year":"2025","ec_funded":1,"publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"CampIT"}],"has_accepted_license":"1","file":[{"content_type":"application/zip","file_id":"20583","creator":"sishida","date_updated":"2025-11-01T18:26:14Z","relation":"source_file","checksum":"4eef80afcb67691cbb6549c4756fa534","file_name":"Thesis_tex.zip","file_size":72487812,"access_level":"open_access","date_created":"2025-11-01T18:26:14Z"},{"file_name":"Thesis_Sadashige_Ishida_PDFA.pdf","file_size":8945141,"access_level":"open_access","date_created":"2025-11-10T08:45:05Z","file_id":"20623","content_type":"application/pdf","success":1,"creator":"sishida","date_updated":"2025-11-10T08:45:05Z","relation":"main_file","checksum":"1e5a557900bf2dce01966b211b15d0fe"}],"oa":1,"alternative_title":["ISTA Thesis"],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"_id":"20551","publication_status":"published","abstract":[{"text":"The space of codimension-2 shapes, such as curves in 3D and surfaces in 4D, is an infinite-dimensional manifold. This thesis explores geometric structures and dynamics on this space, with emphasis on their implications for physics, particularly hydrodynamics.\r\n\r\nOur investigation ranges from theoretical studies of infinite-dimensional symplectic and prequantum geometry to numerical computation of the time evolution of shapes. The thesis presents four main contributions.\r\n\r\nIn the first part, we introduce implicit representations of codimension-2 shapes using a class of complex-valued functions, and prove that the space of these implicit representations forms a prequantum bundle over the codimension-2 shape space. This reveals a new geometric interpretation of the canonical symplectic structure on the codimension-2 shape space.\r\n\r\nIn the second part, we use implicit representations to develop a simulation method for the dynamics of space curves. To handle chaotic systems such as vortex filaments in hydrodynamics, we exploit the infinite degrees of freedom, hidden in both the configuration and dynamics of implicit representations.\r\n\r\nIn the third part, we introduce new symplectic structures on the space of space curves, which generalize the only previously known symplectic structure on this space, allowing for new Hamiltonian dynamics of space curves.\r\n\r\nIn the fourth part, we apply a symplectic viewpoint to a differential geometric problem with practical applications. We derive a new area formula for spherical polygons via prequantization. ","lang":"eng"}],"doi":"10.15479/AT-ISTA-20551","project":[{"call_identifier":"H2020","grant_number":"638176","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","_id":"2533E772-B435-11E9-9278-68D0E5697425"},{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","grant_number":"101045083","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"}],"acknowledgement":"Projects contained in this thesis were financially supported in part by the\r\nEuropean Research Council with grants 1. ERC Consolidator Grant 101045083 CoDiNA,\r\nand 2. the European Union’s Horizon 2020 research and innovation programme under grant\r\nagreement No. 638176.","corr_author":"1","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-070-1"]},"department":[{"_id":"GradSch"},{"_id":"ChWo"}],"file_date_updated":"2025-11-10T08:45:05Z","article_processing_charge":"No","title":"Symplectic-prequantum structures and dynamics on the codimension-2 shape space","date_created":"2025-10-27T10:28:52Z","supervisor":[{"last_name":"Wojtan","orcid":"0000-0001-6646-5546","first_name":"Christopher J","full_name":"Wojtan, Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Chern","first_name":"Albert","full_name":"Chern, Albert"}],"language":[{"iso":"eng"}],"citation":{"short":"S. Ishida, Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space, Institute of Science and Technology Austria, 2025.","chicago":"Ishida, Sadashige. “Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20551\">https://doi.org/10.15479/AT-ISTA-20551</a>.","ista":"Ishida S. 2025. Symplectic-prequantum structures and dynamics on the codimension-2 shape space. Institute of Science and Technology Austria.","ieee":"S. Ishida, “Symplectic-prequantum structures and dynamics on the codimension-2 shape space,” Institute of Science and Technology Austria, 2025.","mla":"Ishida, Sadashige. <i>Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20551\">10.15479/AT-ISTA-20551</a>.","ama":"Ishida S. Symplectic-prequantum structures and dynamics on the codimension-2 shape space. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20551\">10.15479/AT-ISTA-20551</a>","apa":"Ishida, S. (2025). <i>Symplectic-prequantum structures and dynamics on the codimension-2 shape space</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20551\">https://doi.org/10.15479/AT-ISTA-20551</a>"},"OA_place":"publisher","date_updated":"2026-10-02T11:17:04Z","author":[{"last_name":"Ishida","full_name":"Ishida, Sadashige","first_name":"Sadashige","id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","orcid":"0000-0002-3121-3100"}],"related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"12431"},{"id":"20580","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"17361","relation":"part_of_dissertation"},{"id":"12846","status":"public","relation":"part_of_dissertation"}]},"month":"10","page":"141","degree_awarded":"PhD","date_published":"2025-10-31T00:00:00Z","ddc":["516"]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","fulldoi":"https://doi.org/10.15479/AT-ISTA-20234","status":"public","day":"27","year":"2025","ec_funded":1,"type":"dissertation","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","_id":"20234","publication_status":"published","doi":"10.15479/AT-ISTA-20234","abstract":[{"text":"Game Theory is the mathematical formalization of social dynamics - systems where agents interact over time and the evolution of the state of the system depends on the decisions of every player. \r\nThis thesis takes the perspective of a single player and focuses on what they can guarantee in the worst case over the behavior of other players.\r\nIn other words, we consider that the objective of every other player in the game is exactly the opposite to the player.\r\nWe focus on sustained interactions over time, where the players repeatedly obtain quantitative rewards over time, and they are interested in maximizing their long-term performance.\t\r\nFormally, this thesis focuses on zero-sum games with the liminf average objective.\r\nTwo fundamental questions that Game Theory aims to answer are the following.\r\n\r\n1. How much can a player guarantee to obtain after the interaction?\r\n\r\n2. How to act in order to obtain the previously mentioned guarantee?\r\n\r\nThese questions are formalized by the concepts of \"value\" and \"optimal strategies\". \t\r\nWe study their properties on games that exhibit one or more of the following properties. \r\n\r\n1. Partial Observation: \r\nthe players can not perfectly observe the current state of the system during the game. We consider the model of (finite) Partially Observable Markov Decision Processes and prove that finite-memory strategies are sufficient to approximately guarantee the value.\r\n\r\n2. Perturbed Description: \r\nthe formal description of the game is perturbed by a small parameter.\r\nWe consider the model of (finite) Perturbed Matrix Games, and provide algorithms to check various robustness properties and to compute the parameterized value and optimal strategies.\r\n\r\n3. Stochastic Transitions: \r\nthe actions of the players determine the behavior of the evolution of the system, described as a probability distribution over the next state.\r\nWe consider the model of (finite) Perturbed Stochastic Games and provide formulas for the marginal value.\r\n\r\n4. Infinite States: \r\nthe system can be in infinitely many states.\r\nWe consider the model of Random Dynamic Games on a class of infinite graphs, prove the existence of the value, and quantify the concentration of finite-horizon values.","lang":"eng"}],"project":[{"name":"Game Theory","grant_number":"S11407","call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425"},{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","grant_number":"863818"},{"_id":"4029cfc7-b034-11f1-9e55-88ab2ff3b6ee","name":"Bilateral Artificial Intelligence (Chatterjee)","grant_number":"COE12"}],"file":[{"file_name":"2025_Saona_Raimundo_Thesis.pdf","file_size":1503623,"access_level":"open_access","date_created":"2025-08-28T14:47:07Z","success":1,"content_type":"application/pdf","file_id":"20240","creator":"rsaonaur","checksum":"394a651f7de7085e509ef856ffe7bd97","relation":"main_file","date_updated":"2025-08-28T14:47:07Z"},{"date_created":"2025-08-28T14:47:12Z","file_name":"2025_Saona_Raimundo_Thesis.zip","file_size":622747,"access_level":"closed","creator":"rsaonaur","date_updated":"2025-08-28T14:47:12Z","checksum":"09fb2633e66aac80433d373f4180c5b4","relation":"source_file","file_id":"20241","content_type":"application/zip"}],"oa":1,"alternative_title":["ISTA Thesis"],"publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2025-08-28T14:47:12Z","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"article_processing_charge":"No","title":"Robustness of solutions in game theory: Values and strategies in partially observable, perturbed, stochastic, and infinite games","date_created":"2025-08-27T14:00:13Z","language":[{"iso":"eng"}],"supervisor":[{"last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu"}],"acknowledgement":"Funding sources The works included in this thesis were partially supported by:\r\n• Austrian Science Fund (FWF), grants 10.55776/COE12 and No RiSE/SHiNE S11407,\r\n• French Agence Nationale de la Recherche (ANR), grants ANR-21-CE40-0020 (CONVERGENCE) and ANR-20-CE40-0002 (GrHyDy),\r\n• Fondation Mathématique Jaques Hadamard, grant PGMO RSG 2018-0031H,\r\n• European Research Council (ERC), Consolidator grant 863818 (ForM-SMArt),\r\n• Agencia Nacional de Investigación y Desarrollo (ANID Chile), grant ACT210005,\r\n• Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt Chile), grant 1220174,\r\n• Comisión Nacional de Investigación Científica y Tecnológica (CONICYT Chile), grant\r\nPII 20150140,\r\n• Evaluation-orientation de la Coopération Scientifique and Comisión Nacional de Investigación Científica y Tecnológica (ECOS-CONICYT), grant C15E03,\r\n• European Cooperation in Science and Technology (E-COST), grants CA16228 - European\r\nNetwork for Game Theory (GAMENET) and E-COST-GRANT-CA16228-c5a69859.\r\n","corr_author":"1","related_material":{"record":[{"id":"9311","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"19508","status":"public"},{"status":"public","id":"17037","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"18266","status":"public"}]},"month":"08","page":"125","degree_awarded":"PhD","date_published":"2025-08-27T00:00:00Z","ddc":["519"],"citation":{"short":"R.J. Saona Urmeneta, Robustness of Solutions in Game Theory: Values and Strategies in Partially Observable, Perturbed, Stochastic, and Infinite Games, Institute of Science and Technology Austria, 2025.","ieee":"R. J. Saona Urmeneta, “Robustness of solutions in game theory: Values and strategies in partially observable, perturbed, stochastic, and infinite games,” Institute of Science and Technology Austria, 2025.","chicago":"Saona Urmeneta, Raimundo J. “Robustness of Solutions in Game Theory: Values and Strategies in Partially Observable, Perturbed, Stochastic, and Infinite Games.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20234\">https://doi.org/10.15479/AT-ISTA-20234</a>.","ista":"Saona Urmeneta RJ. 2025. Robustness of solutions in game theory: Values and strategies in partially observable, perturbed, stochastic, and infinite games. Institute of Science and Technology Austria.","mla":"Saona Urmeneta, Raimundo J. <i>Robustness of Solutions in Game Theory: Values and Strategies in Partially Observable, Perturbed, Stochastic, and Infinite Games</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20234\">10.15479/AT-ISTA-20234</a>.","ama":"Saona Urmeneta RJ. Robustness of solutions in game theory: Values and strategies in partially observable, perturbed, stochastic, and infinite games. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20234\">10.15479/AT-ISTA-20234</a>","apa":"Saona Urmeneta, R. J. (2025). <i>Robustness of solutions in game theory: Values and strategies in partially observable, perturbed, stochastic, and infinite games</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20234\">https://doi.org/10.15479/AT-ISTA-20234</a>"},"OA_place":"publisher","doi_confirm":"1","date_updated":"2026-10-02T11:30:08Z","author":[{"last_name":"Saona Urmeneta","orcid":"0000-0001-5103-038X","full_name":"Saona Urmeneta, Raimundo J","first_name":"Raimundo J","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425"}]},{"das_tickbox":"0","month":"02","related_material":{"record":[{"id":"20234","status":"public","relation":"dissertation_contains"}]},"page":"482-505","date_published":"2025-02-01T00:00:00Z","issue":"1","citation":{"mla":"Attia, Luc, et al. “Marginal Values of a Stochastic Game.” <i>Mathematics of Operations Research</i>, vol. 50, no. 1, Institute for Operations Research and the Management Sciences, 2025, pp. 482–505, doi:<a href=\"https://doi.org/10.1287/moor.2023.0297\">10.1287/moor.2023.0297</a>.","ama":"Attia L, Oliu-Barton M, Saona Urmeneta RJ. Marginal values of a stochastic game. <i>Mathematics of Operations Research</i>. 2025;50(1):482-505. doi:<a href=\"https://doi.org/10.1287/moor.2023.0297\">10.1287/moor.2023.0297</a>","apa":"Attia, L., Oliu-Barton, M., &#38; Saona Urmeneta, R. J. (2025). Marginal values of a stochastic game. <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences. <a href=\"https://doi.org/10.1287/moor.2023.0297\">https://doi.org/10.1287/moor.2023.0297</a>","short":"L. Attia, M. Oliu-Barton, R.J. Saona Urmeneta, Mathematics of Operations Research 50 (2025) 482–505.","chicago":"Attia, Luc, Miquel Oliu-Barton, and Raimundo J Saona Urmeneta. “Marginal Values of a Stochastic Game.” <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences, 2025. <a href=\"https://doi.org/10.1287/moor.2023.0297\">https://doi.org/10.1287/moor.2023.0297</a>.","ista":"Attia L, Oliu-Barton M, Saona Urmeneta RJ. 2025. Marginal values of a stochastic game. Mathematics of Operations Research. 50(1), 482–505.","ieee":"L. Attia, M. Oliu-Barton, and R. J. Saona Urmeneta, “Marginal values of a stochastic game,” <i>Mathematics of Operations Research</i>, vol. 50, no. 1. Institute for Operations Research and the Management Sciences, pp. 482–505, 2025."},"supplementarymaterial":"unclear","author":[{"first_name":"Luc","full_name":"Attia, Luc","last_name":"Attia"},{"full_name":"Oliu-Barton, Miquel","first_name":"Miquel","last_name":"Oliu-Barton"},{"last_name":"Saona Urmeneta","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","full_name":"Saona Urmeneta, Raimundo J","first_name":"Raimundo J","orcid":"0000-0001-5103-038X"}],"date_updated":"2026-10-02T11:29:44Z","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"article_processing_charge":"No","title":"Marginal values of a stochastic game","publication_identifier":{"eissn":["1526-5471"],"issn":["0364-765X"]},"scopus_import":"1","date_created":"2024-05-22T11:41:14Z","language":[{"iso":"eng"}],"article_type":"original","external_id":{"isi":["001184648000001"]},"acknowledgement":"This work was supported by Fondation CFM pour la Recherche; the European Research Council [Grant ERC-CoG-863818 (ForM-SMArt)]; and Agence Nationale de la Recherche [Grant ANR-21-CE40-0020].","doi":"10.1287/moor.2023.0297","abstract":[{"text":"Zero-sum stochastic games are parameterized by payoffs, transitions, and possibly a discount rate. In this article, we study how the main solution concepts, the discounted and undiscounted values, vary when these parameters are perturbed. We focus on the marginal values, introduced by Mills in 1956 in the context of matrix games—that is, the directional derivatives of the value along any fixed perturbation. We provide a formula for the marginal values of a discounted stochastic game. Further, under mild assumptions on the perturbation, we provide a formula for their limit as the discount rate vanishes and for the marginal values of an undiscounted stochastic game. We also show, via an example, that the two latter differ in general.","lang":"eng"}],"project":[{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","name":"Formal Methods for Stochastic Models: Algorithms and Applications","grant_number":"863818","call_identifier":"H2020"}],"publication_status":"published","_id":"17037","publication":"Mathematics of Operations Research","quality_controlled":"1","volume":50,"isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","intvolume":"        50","fulldoi":"https://doi.org/10.1287/moor.2023.0297","OA_type":"closed access","status":"public","ec_funded":1,"type":"journal_article","year":"2025","oa_version":"None","publisher":"Institute for Operations Research and the Management Sciences","day":"01","researchdata_availability":"unclear"},{"publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"_id":"19540","abstract":[{"lang":"eng","text":"This thesis deals with several different models for complex quantum mechanical systems and is structured in three main parts. \r\n\t\r\nIn Part I, we study mean field random matrices as models for quantum Hamiltonians. Our focus lies on proving concentration estimates for resolvents of random matrices, so-called local laws, mostly in the setting of multiple resolvents. These estimates have profound consequences for eigenvector overlaps and thermalization problems. More concretely, we obtain, e.g., the optimal eigenstate thermalization hypothesis (ETH) uniformly in the spectrum for Wigner matrices, an optimal lower bound on non-Hermitian eigenvector overlaps, and prethermalization for deformed Wigner matrices.\tIn order to prove our novel multi-resolvent local laws, we develop and devise two main methods, the static Psi-method and the dynamical Zigzag strategy. \r\n\t\r\nIn Part II, we study Bardeen-Cooper-Schrieffer (BCS) theory, the standard mean field microscopic theory of superconductivity. We focus on asymptotic formulas for the characteristic critical temperature and energy gap of a superconductor and prove universality of their ratio in various physical regimes. Additionally, we investigate multi-band superconductors and show that inter-band coupling effects can only enhance the critical temperature. \r\n\t\r\nIn Part III, we study quantum lattice systems. On the one hand, we show a strong version of the local-perturbations-perturb-locally (LPPL) principle for the ground state of weakly interacting quantum spin systems with a uniform on-site gap. On the other hand, we introduce a notion of a local gap and rigorously justify response theory and the Kubo formula under the weakened assumption of a local gap. \r\n\t\r\nAdditionally, we discuss two classes of problems which do not fit into the three main parts of the thesis. These are deformational rigidity of Liouville metrics on the torus and relativistic toy models of particle creation via interior-boundary-conditions (IBCs).  "}],"doi":"10.15479/AT-ISTA-19540","project":[{"call_identifier":"H2020","grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"file":[{"date_created":"2025-04-10T21:14:18Z","file_name":"Henheik-Thesis_source_final.zip","access_level":"closed","file_size":4107587,"creator":"shenheik","relation":"source_file","date_updated":"2025-04-10T21:14:18Z","checksum":"b8477ae5578436c72c3bb4193ad34ac5","file_id":"19542","content_type":"application/zip"},{"date_created":"2025-04-11T13:16:05Z","file_size":9999492,"access_level":"open_access","file_name":"Henheik-Thesis-pdfa_FINAL.pdf","checksum":"e9fc0ea12ec46c9f71110c33217c4140","relation":"main_file","date_updated":"2025-04-11T13:16:05Z","creator":"shenheik","success":1,"content_type":"application/pdf","file_id":"19553"},{"date_created":"2025-04-23T14:10:27Z","access_level":"closed","file_size":13276442,"file_name":"Henheik-Thesis-Volume1_print.pdf","date_updated":"2025-04-23T14:10:27Z","relation":"other","checksum":"f94580f86c785e7108eb116cd189e225","creator":"cchlebak","content_type":"application/pdf","file_id":"19615"},{"date_created":"2025-04-23T14:11:05Z","access_level":"closed","file_size":7628767,"file_name":"Henheik-Thesis-Volume2_print.pdf","relation":"other","date_updated":"2025-04-23T14:11:05Z","checksum":"b927ead3c78020ffb32918911deedb74","creator":"cchlebak","file_id":"19616","content_type":"application/pdf"}],"alternative_title":["ISTA Thesis"],"oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","has_accepted_license":"1","day":"10","ec_funded":1,"type":"dissertation","year":"2025","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","fulldoi":"https://doi.org/10.15479/AT-ISTA-19540","status":"public","date_published":"2025-04-10T00:00:00Z","ddc":["519"],"month":"04","related_material":{"record":[{"id":"14343","status":"public","relation":"part_of_dissertation"},{"id":"13317","status":"public","relation":"part_of_dissertation"},{"id":"11732","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"12184"},{"id":"14421","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"10623","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"18112","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"19001"},{"relation":"part_of_dissertation","status":"public","id":"10642"},{"relation":"part_of_dissertation","status":"public","id":"19545"},{"id":"19546","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"19550","status":"public"},{"relation":"part_of_dissertation","id":"19551","status":"public"},{"status":"public","id":"19552","relation":"part_of_dissertation"},{"id":"17049","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"18764","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"19547","status":"public"},{"id":"19548","status":"public","relation":"part_of_dissertation"},{"id":"18656","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"14542","relation":"part_of_dissertation"}]},"page":"720","degree_awarded":"PhD","date_updated":"2026-10-02T11:31:51Z","doi_confirm":"1","author":[{"orcid":"0000-0003-1106-327X","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","first_name":"Sven Joscha","last_name":"Henheik"}],"citation":{"ama":"Henheik SJ. Modeling complex quantum systems: Random matrices, BCS theory, and quantum lattice systems. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19540\">10.15479/AT-ISTA-19540</a>","mla":"Henheik, Sven Joscha. <i>Modeling Complex Quantum Systems: Random Matrices, BCS Theory, and Quantum Lattice Systems</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19540\">10.15479/AT-ISTA-19540</a>.","apa":"Henheik, S. J. (2025). <i>Modeling complex quantum systems: Random matrices, BCS theory, and quantum lattice systems</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19540\">https://doi.org/10.15479/AT-ISTA-19540</a>","short":"S.J. Henheik, Modeling Complex Quantum Systems: Random Matrices, BCS Theory, and Quantum Lattice Systems, Institute of Science and Technology Austria, 2025.","chicago":"Henheik, Sven Joscha. “Modeling Complex Quantum Systems: Random Matrices, BCS Theory, and Quantum Lattice Systems.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19540\">https://doi.org/10.15479/AT-ISTA-19540</a>.","ista":"Henheik SJ. 2025. Modeling complex quantum systems: Random matrices, BCS theory, and quantum lattice systems. Institute of Science and Technology Austria.","ieee":"S. J. Henheik, “Modeling complex quantum systems: Random matrices, BCS theory, and quantum lattice systems,” Institute of Science and Technology Austria, 2025."},"OA_place":"publisher","date_created":"2025-04-10T21:21:18Z","supervisor":[{"last_name":"Erdös","first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-057-2"]},"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"file_date_updated":"2025-04-23T14:11:05Z","title":"Modeling complex quantum systems: Random matrices, BCS theory, and quantum lattice systems","article_processing_charge":"No","corr_author":"1"},{"publication_identifier":{"issn":["2663-337X"]},"department":[{"_id":"GradSch"},{"_id":"MiLe"}],"file_date_updated":"2025-02-18T14:25:59Z","title":"Emergent physics of rotating quantum impurities in many-body environments","article_processing_charge":"No","date_created":"2025-02-18T01:41:27Z","supervisor":[{"full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","orcid":"0000-0002-6990-7802","last_name":"Lemeshko"}],"language":[{"iso":"eng"}],"acknowledgement":"I am grateful to the European Research Council (ERC) [10.3030/801770] and Austrian\r\nScience Fund (FWF) [10.55776/F1004] for funding my research and to the Physical\r\nReview journals for publishing it. I also want to thank the VCQ (previously CoQuS) and\r\nIQOQI for organizing wonderful networking events for the physics community in Vienna\r\nand Innsbruck, respectively. Moreover, I thank Austrian Science Fund (FWF) for the\r\ncontinuous support for quantum research.","corr_author":"1","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"10845"},{"relation":"part_of_dissertation","status":"public","id":"7933"},{"relation":"part_of_dissertation","id":"18087","status":"public"}]},"month":"02","page":"86","degree_awarded":"PhD","date_published":"2025-02-18T00:00:00Z","ddc":["539","535","541"],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","citation":{"chicago":"Maslov, Mikhail. “Emergent Physics of Rotating Quantum Impurities in Many-Body Environments.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/at:ista:19048\">https://doi.org/10.15479/at:ista:19048</a>.","ista":"Maslov M. 2025. Emergent physics of rotating quantum impurities in many-body environments. Institute of Science and Technology Austria.","ieee":"M. Maslov, “Emergent physics of rotating quantum impurities in many-body environments,” Institute of Science and Technology Austria, 2025.","short":"M. Maslov, Emergent Physics of Rotating Quantum Impurities in Many-Body Environments, Institute of Science and Technology Austria, 2025.","apa":"Maslov, M. (2025). <i>Emergent physics of rotating quantum impurities in many-body environments</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:19048\">https://doi.org/10.15479/at:ista:19048</a>","mla":"Maslov, Mikhail. <i>Emergent Physics of Rotating Quantum Impurities in Many-Body Environments</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/at:ista:19048\">10.15479/at:ista:19048</a>.","ama":"Maslov M. Emergent physics of rotating quantum impurities in many-body environments. 2025. doi:<a href=\"https://doi.org/10.15479/at:ista:19048\">10.15479/at:ista:19048</a>"},"OA_place":"publisher","date_updated":"2026-10-02T11:36:24Z","author":[{"last_name":"Maslov","orcid":"0000-0003-4074-2570","full_name":"Maslov, Mikhail","first_name":"Mikhail","id":"2E65BB0E-F248-11E8-B48F-1D18A9856A87"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"CampIT"},{"_id":"E-Lib"},{"_id":"SSU"}],"has_accepted_license":"1","fulldoi":"https://doi.org/10.15479/at:ista:19048","status":"public","day":"18","type":"dissertation","year":"2025","ec_funded":1,"oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","_id":"19048","tmp":{"image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"publication_status":"published","abstract":[{"text":"Rotations are found in physics problems at all scales: from spatial motion of celestial bodies, to transitions between quantum states of atoms and molecules. Mathematically, they represent a fundamental class of transformations and symmetries. Unlike spatial displacements, rotational transformations in three-dimensional space  are non-commutative: the result of applying a sequence of rotations depends on the order of these operations. This feature makes the emergent physics that involves rotations rather intricate, but instrumental for studies of highly-interconnected many-body systems. In the presence of an environment, rotational properties of an object change, due to the interaction with particles of the environment. Owing to the complexity of this interaction, it can be engineered to exhibit certain properties of interest. In this Thesis, we examine several scenarios of how the rotational behavior of an impurity can be modified by interactions with its environment.","lang":"eng"}],"doi":"10.15479/at:ista:19048","project":[{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","call_identifier":"H2020","grant_number":"801770"},{"grant_number":"F100403","name":"Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions","_id":"7c040762-9f16-11ee-852c-dd79eeee4ab3"}],"file":[{"content_type":"application/pdf","file_id":"19061","checksum":"5822a4dd31724c512b37c658af1787ab","relation":"main_file","date_updated":"2025-02-18T14:25:59Z","creator":"mmaslov","file_size":7779825,"access_level":"open_access","file_name":"thesis_Maslov.pdf","date_created":"2025-02-18T14:25:59Z"},{"relation":"source_file","checksum":"89bdce4774406d26ceca88a8bbcd6a9a","date_updated":"2025-02-18T14:25:59Z","creator":"mmaslov","file_id":"19062","content_type":"application/zip","date_created":"2025-02-18T14:25:59Z","access_level":"open_access","file_size":14453726,"file_name":"thesis_Maslov_source.zip"}],"oa":1,"alternative_title":["ISTA Thesis"]},{"fulldoi":"https://doi.org/10.15479/AT-ISTA-20147","status":"public","year":"2025","ec_funded":1,"type":"dissertation","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","day":"07","publisher_comment":"In reference to IEEE copyrighted material which is used with permission in this thesis, the IEEE does not\r\nendorse any of ISTA's products or services. Internal or personal use of this\r\nmaterial is permitted. If interested in reprinting/republishing IEEE copyrighted material for advertising or promotional\r\npurposes or for creating new collective works for resale or redistribution, please go to\r\nhttp://www.ieee.org/publications_standards/publications/rights/rights_link.html to learn how to obtain a License from\r\nRightsLink.  If applicable, University Microfilms and/or ProQuest Library, or the Archives of Canada may supply single copies of the dissertation.","has_accepted_license":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","file":[{"date_created":"2025-08-21T09:40:28Z","file_name":"2025_Sarac_NaciEge_Thesis.zip","file_size":8884801,"access_level":"closed","creator":"esarac","checksum":"0f3015f1db36576a23d8d669afb60b41","date_updated":"2025-09-10T08:19:51Z","relation":"source_file","file_id":"20200","content_type":"application/x-zip-compressed"},{"checksum":"332ed2fe61f580641664ec3f05d30f14","relation":"main_file","date_updated":"2025-08-21T09:40:34Z","creator":"esarac","content_type":"application/pdf","file_id":"20201","success":1,"date_created":"2025-08-21T09:40:34Z","file_size":2955584,"access_level":"open_access","file_name":"2025_Sarac_NaciEge_Thesis.pdf"}],"alternative_title":["ISTA Thesis"],"oa":1,"abstract":[{"text":"Quantitative properties offer a framework for specifying and verifying system behaviors beyond the traditional boolean perspective. For example, while a boolean property may specify whether a server eventually grants every request it receives, a quantitative one may map each server execution to its average response time. This quantitative view is relatively well-studied in the context of static verification. However, although such properties often appear in practice as performance or robustness measures in a dynamic verification context, a general theoretical framework for their analysis and classification from a monitoring perspective is still missing.\r\n\r\nIn this thesis, we aim to develop such a framework that takes resource-precision tradeoffs of monitors as a central consideration. We present the first theory of monitorability for quantitative properties where monitors can be naturally approximate and compared regarding their precision and resource use. In particular, we show that additional monitor resources such as registers or states lead to strictly better approximations for some properties. To enable such analyses in a machine-model independent way, we describe an abstract notion of monitors that can be instantiated with concrete models of monitors. Within this framework, we study how abstract monitors behave and identify classes of properties amenable to approximate monitoring with resource-precision considerations. We then extend the boolean safety-liveness dichotomy and safety-progress hierarchy to the quantitative setting with a monitoring perspective. In particular, we prove that every property is the pointwise minimum of a safety property and a liveness property, and properties that are both safe and co-safe can be approximately monitored arbitrarily precisely using only finitely many states. We also study the classes of quantitative properties definable by finite-state quantitative automata and provide algorithms for deciding their safety or liveness as well as their safety-liveness decompositions. Finally, we present the first general-purpose tool for automating the analysis, verification, and monitoring of quantitative automata.\r\n\r\n\r\n","lang":"eng"}],"doi":"10.15479/AT-ISTA-20147","project":[{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","call_identifier":"FWF","name":"Formal methods for the design and analysis of complex systems"},{"_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software","grant_number":"101020093","call_identifier":"H2020"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_status":"published","_id":"20147","corr_author":"1","acknowledgement":"This work was supported in part by the Austrian Science Fund (FWF)\r\nunder grant Z211-N23 (Wittgenstein Award) and the ERC-2020-AdG 101020093.\r\n","department":[{"_id":"GradSch"},{"_id":"ToHe"}],"file_date_updated":"2025-09-10T08:19:51Z","title":"A monitoring-oriented theory and classification of quantitative specifications","article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-08-07T15:57:57Z","supervisor":[{"orcid":"0000-0002-2985-7724","first_name":"Thomas A","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger"}],"language":[{"iso":"eng"}],"OA_place":"publisher","citation":{"ama":"Sarac NE. A monitoring-oriented theory and classification of quantitative specifications. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20147\">10.15479/AT-ISTA-20147</a>","mla":"Sarac, Naci E. <i>A Monitoring-Oriented Theory and Classification of Quantitative Specifications</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20147\">10.15479/AT-ISTA-20147</a>.","apa":"Sarac, N. E. (2025). <i>A monitoring-oriented theory and classification of quantitative specifications</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20147\">https://doi.org/10.15479/AT-ISTA-20147</a>","short":"N.E. Sarac, A Monitoring-Oriented Theory and Classification of Quantitative Specifications, Institute of Science and Technology Austria, 2025.","ieee":"N. E. Sarac, “A monitoring-oriented theory and classification of quantitative specifications,” Institute of Science and Technology Austria, 2025.","chicago":"Sarac, Naci E. “A Monitoring-Oriented Theory and Classification of Quantitative Specifications.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20147\">https://doi.org/10.15479/AT-ISTA-20147</a>.","ista":"Sarac NE. 2025. A monitoring-oriented theory and classification of quantitative specifications. Institute of Science and Technology Austria."},"author":[{"last_name":"Sarac","full_name":"Sarac, Naci E","id":"8C6B42F8-C8E6-11E9-A03A-F2DCE5697425","first_name":"Naci E"}],"date_updated":"2026-10-02T11:44:51Z","doi_confirm":"1","degree_awarded":"PhD","related_material":{"record":[{"id":"11775","status":"public","relation":"part_of_dissertation"},{"status":"deleted","id":"13140","relation":"part_of_dissertation"},{"id":"19741","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"deleted","id":"19643"},{"relation":"part_of_dissertation","id":"13221","status":"public"},{"relation":"part_of_dissertation","id":"9356","status":"public"},{"relation":"part_of_dissertation","id":"20342","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"17634"}]},"month":"08","page":"149","date_published":"2025-08-07T00:00:00Z","ddc":["000"]},{"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_status":"published","_id":"10045","publication":"Mathematical Programming","abstract":[{"text":"Given a fixed finite metric space (V,μ), the {\\em minimum 0-extension problem}, denoted as 0-Ext[μ], is equivalent to the following optimization problem: minimize function of the form minx∈Vn∑ifi(xi)+∑ijcijμ(xi,xj) where cij,cvi are given nonnegative costs and fi:V→R are functions given by fi(xi)=∑v∈Vcviμ(xi,v). The computational complexity of 0-Ext[μ] has been recently established by Karzanov and by Hirai: if metric μ is {\\em orientable modular} then 0-Ext[μ] can be solved in polynomial time, otherwise 0-Ext[μ] is NP-hard. To prove the tractability part, Hirai developed a theory of discrete convex functions on orientable modular graphs generalizing several known classes of functions in discrete convex analysis, such as L♮-convex functions. We consider a more general version of the problem in which unary functions fi(xi) can additionally have terms of the form cuv;iμ(xi,{u,v}) for {u,v}∈F, where set F⊆(V2) is fixed. We extend the complexity classification above by providing an explicit condition on (μ,F) for the problem to be tractable. In order to prove the tractability part, we generalize Hirai's theory and define a larger class of discrete convex functions. It covers, in particular, another well-known class of functions, namely submodular functions on an integer lattice. Finally, we improve the complexity of Hirai's algorithm for solving 0-Ext on orientable modular graphs.\r\n","lang":"eng"}],"doi":"10.1007/s10107-024-02064-5","volume":209,"file":[{"date_created":"2025-04-16T09:36:08Z","file_name":"2025_MathProgramming_Dvorak.pdf","access_level":"open_access","file_size":839510,"creator":"dernst","checksum":"25d9bd490719b45eca84f4d93a06c69f","relation":"main_file","date_updated":"2025-04-16T09:36:08Z","file_id":"19578","content_type":"application/pdf","success":1}],"quality_controlled":"1","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","has_accepted_license":"1","isi":1,"day":"01","researchdata_availability":"no","type":"journal_article","year":"2025","oa_version":"Published Version","publisher":"Springer Nature","fulldoi":"https://doi.org/10.1007/s10107-024-02064-5","status":"public","OA_type":"hybrid","intvolume":"       209","date_published":"2025-01-01T00:00:00Z","ddc":["004"],"month":"01","page":"279-322","das_tickbox":"0","date_updated":"2026-10-02T11:45:16Z","author":[{"orcid":"0000-0001-5293-214X","id":"40ED02A8-C8B4-11E9-A9C0-453BE6697425","first_name":"Martin","full_name":"Dvorak, Martin","last_name":"Dvorak"},{"first_name":"Vladimir","full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov"}],"supplementarymaterial":"no","citation":{"ama":"Dvorak M, Kolmogorov V. Generalized minimum 0-extension problem and discrete convexity. <i>Mathematical Programming</i>. 2025;209:279-322. doi:<a href=\"https://doi.org/10.1007/s10107-024-02064-5\">10.1007/s10107-024-02064-5</a>","mla":"Dvorak, Martin, and Vladimir Kolmogorov. “Generalized Minimum 0-Extension Problem and Discrete Convexity.” <i>Mathematical Programming</i>, vol. 209, Springer Nature, 2025, pp. 279–322, doi:<a href=\"https://doi.org/10.1007/s10107-024-02064-5\">10.1007/s10107-024-02064-5</a>.","apa":"Dvorak, M., &#38; Kolmogorov, V. (2025). Generalized minimum 0-extension problem and discrete convexity. <i>Mathematical Programming</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10107-024-02064-5\">https://doi.org/10.1007/s10107-024-02064-5</a>","short":"M. Dvorak, V. Kolmogorov, Mathematical Programming 209 (2025) 279–322.","ista":"Dvorak M, Kolmogorov V. 2025. Generalized minimum 0-extension problem and discrete convexity. Mathematical Programming. 209, 279–322.","chicago":"Dvorak, Martin, and Vladimir Kolmogorov. “Generalized Minimum 0-Extension Problem and Discrete Convexity.” <i>Mathematical Programming</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s10107-024-02064-5\">https://doi.org/10.1007/s10107-024-02064-5</a>.","ieee":"M. Dvorak and V. Kolmogorov, “Generalized minimum 0-extension problem and discrete convexity,” <i>Mathematical Programming</i>, vol. 209. Springer Nature, pp. 279–322, 2025."},"OA_place":"publisher","arxiv":1,"date_created":"2021-09-27T10:48:23Z","language":[{"iso":"eng"}],"keyword":["minimum 0-extension problem","metric labeling problem","discrete metric spaces","metric extensions","computational complexity","valued constraint satisfaction problems","discrete convex analysis","L-convex functions"],"publication_identifier":{"eissn":["1436-4646"],"issn":["0025-5610"]},"scopus_import":"1","file_date_updated":"2025-04-16T09:36:08Z","department":[{"_id":"GradSch"},{"_id":"VlKo"}],"article_processing_charge":"Yes (via OA deal)","title":"Generalized minimum 0-extension problem and discrete convexity","acknowledgement":"We thank the anonymous reviewers for their careful reading of our manuscript and their many insightful comments and suggestions. Open access funding provided by Institute of Science and Technology (IST Austria).","external_id":{"isi":["001176563300001"],"arxiv":["2109.10203"]},"corr_author":"1","article_type":"original"},{"corr_author":"1","acknowledgement":"The research presented in this thesis was funded with the Wittgenstein Prize,\r\nAustrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research\r\nCenter TRR 109, ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF),\r\ngrant no. I 02979-N35.\r\n","title":"Structures and computations in topological data analysis","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"HeEd"}],"file_date_updated":"2025-02-04T16:22:07Z","publication_identifier":{"issn":["2663-337X"]},"keyword":["topological data analysis","chromatic point set","alpha complex","persistent homology","six pack","sheaf","microlocal discrete Morse","injective resolution","collapse","knot","discrete Morse theory"],"supervisor":[{"orcid":"0000-0002-9823-6833","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner"}],"language":[{"iso":"eng"}],"date_created":"2025-01-31T17:04:40Z","OA_place":"publisher","citation":{"apa":"Draganov, O. (2025). <i>Structures and computations in topological data analysis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:18979\">https://doi.org/10.15479/at:ista:18979</a>","ama":"Draganov O. Structures and computations in topological data analysis. 2025. doi:<a href=\"https://doi.org/10.15479/at:ista:18979\">10.15479/at:ista:18979</a>","mla":"Draganov, Ondrej. <i>Structures and Computations in Topological Data Analysis</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/at:ista:18979\">10.15479/at:ista:18979</a>.","ieee":"O. Draganov, “Structures and computations in topological data analysis,” Institute of Science and Technology Austria, 2025.","ista":"Draganov O. 2025. Structures and computations in topological data analysis. Institute of Science and Technology Austria.","chicago":"Draganov, Ondrej. “Structures and Computations in Topological Data Analysis.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/at:ista:18979\">https://doi.org/10.15479/at:ista:18979</a>.","short":"O. Draganov, Structures and Computations in Topological Data Analysis, Institute of Science and Technology Austria, 2025."},"author":[{"last_name":"Draganov","id":"2B23F01E-F248-11E8-B48F-1D18A9856A87","first_name":"Ondrej","full_name":"Draganov, Ondrej","orcid":"0000-0003-0464-3823"}],"date_updated":"2026-10-02T11:57:00Z","degree_awarded":"PhD","page":"140","month":"02","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"15091"},{"id":"18981","status":"public","relation":"part_of_dissertation"}]},"ddc":["514","004"],"date_published":"2025-02-03T00:00:00Z","status":"public","fulldoi":"https://doi.org/10.15479/at:ista:18979","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","type":"dissertation","year":"2025","day":"03","has_accepted_license":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","alternative_title":["ISTA Thesis"],"oa":1,"file":[{"file_id":"18983","content_type":"application/zip","creator":"odragano","date_updated":"2025-01-31T16:58:30Z","checksum":"af6567e5d35e5eb330b8925ae37f1998","relation":"source_file","file_name":"Thesis.zip","access_level":"closed","file_size":11899491,"date_created":"2025-01-31T16:58:30Z"},{"creator":"odragano","relation":"main_file","date_updated":"2025-02-04T16:22:07Z","checksum":"c3fef68e35b9dc2020b2ca6006da6343","file_id":"19000","content_type":"application/pdf","date_created":"2025-02-04T16:22:07Z","file_name":"Thesis.pdf","access_level":"open_access","file_size":8857514}],"project":[{"_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes","call_identifier":"FWF","grant_number":"I02979-N35"},{"name":"Mathematics, Computer Science","call_identifier":"FWF","grant_number":"Z00342","_id":"268116B8-B435-11E9-9278-68D0E5697425"}],"doi":"10.15479/at:ista:18979","abstract":[{"lang":"eng","text":"Topological Data Analysis (TDA) is a discipline utilizing the mathematical field of topology to study data, most prominently collections of point sets. This thesis summarizes three projects related to computations in TDA.\r\n\r\nThe first one establishes a variant of TDA for chromatic point sets, where each point is given a color. For example, we are given positions of cells within a tumor microenvironment, and color the cancerous cells red, and the immune cells blue.\r\n\r\nThe aim is then to give a quantitative description of how the two or more sets of points spatially interact. Building on image, kernel and cokernel variants of persistent homology, we suggest six-packs of persistent diagrams as such a descriptor.\r\n\r\nWe describe a construction of a chromatic alpha complex, which enables  efficient computation of several variants of the six-packs. We give topological descriptions of natural subcomplexes of the chromatic alpha complex, and show that the radii of the simplices form a discrete Morse function. Finally, we provide an implementation of the presented chromatic TDA pipeline.\r\n\r\nThe second part aims to translate a powerful tool of sheaf theory to elementary terms using labeled matrices. The goal is to enable their use in computational settings. We show that derived categories of sheaves over finite posets have, up to isomorphism, unique objects---minimal injective resolutions---and give a concrete algorithm to compute them. We further describe simple algorithms to compute derived pushforwards and pullbacks for monotonic maps, and their proper variants for inclusions, and demonstrate their tractability by providing an implementation. Finally, we suggest a discrete definition of microsupport and show desirable properties inspired by discrete Morse theory.\r\n\r\nIn the last part, we present a collection of observations about collapses. We give a characterization of collapsibility in terms of unitriangular submatrices of the boundary matrix, a cotree-tree decomposition, and the optimal solution to a variant of the Procrustes problem. We establish relation between dual collapses and relative Morse theory and pose several open questions. Finally, focusing on complexes embedded in the three-dimensional Euclidean space, we describe a relation between the collapsibility and the triviality of a polygonal knot."}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_status":"published","_id":"18979"},{"corr_author":"1","publication_identifier":{"issn":["2663-337X"]},"title":"Nanoparticle-based precursors toward advanced crystalline inorganic solids","article_processing_charge":"No","file_date_updated":"2026-10-03T22:30:02Z","department":[{"_id":"GradSch"},{"_id":"MaIb"}],"supervisor":[{"full_name":"Ibáñez, Maria","first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5013-2843","last_name":"Ibáñez"},{"last_name":"Protesescu","first_name":"Loredana","full_name":"Protesescu, Loredana"},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger"}],"language":[{"iso":"eng"}],"date_created":"2025-10-01T09:04:00Z","citation":{"apa":"Lee, S. (2025). <i>Nanoparticle-based precursors toward advanced crystalline inorganic solids</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20415\">https://doi.org/10.15479/AT-ISTA-20415</a>","mla":"Lee, Seungho. <i>Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20415\">10.15479/AT-ISTA-20415</a>.","ama":"Lee S. Nanoparticle-based precursors toward advanced crystalline inorganic solids. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20415\">10.15479/AT-ISTA-20415</a>","ieee":"S. Lee, “Nanoparticle-based precursors toward advanced crystalline inorganic solids,” Institute of Science and Technology Austria, 2025.","chicago":"Lee, Seungho. “Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20415\">https://doi.org/10.15479/AT-ISTA-20415</a>.","ista":"Lee S. 2025. Nanoparticle-based precursors toward advanced crystalline inorganic solids. Institute of Science and Technology Austria.","short":"S. Lee, Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids, Institute of Science and Technology Austria, 2025."},"OA_place":"publisher","date_updated":"2026-10-03T22:30:07Z","author":[{"first_name":"Seungho","full_name":"Lee, Seungho","id":"BB243B88-D767-11E9-B658-BC13E6697425","orcid":"0000-0002-6962-8598","last_name":"Lee"}],"page":"144","month":"10","related_material":{"record":[{"id":"15357","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"12237","status":"public"}]},"degree_awarded":"PhD","ddc":["540"],"date_published":"2025-10-01T00:00:00Z","status":"public","fulldoi":"https://doi.org/10.15479/AT-ISTA-20415","day":"01","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","year":"2025","type":"dissertation","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","has_accepted_license":"1","oa":1,"alternative_title":["ISTA Thesis"],"file":[{"checksum":"fa6d5946feb37b678ee1c6dffb4fa167","relation":"source_file","date_updated":"2026-10-03T22:30:02Z","embargo_to":"open_access","creator":"slee","file_id":"20420","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-10-03T12:29:43Z","file_size":88706648,"access_level":"closed","file_name":"2025_Lee_Seungho_Thesis.docx"},{"date_updated":"2026-10-03T22:30:02Z","checksum":"c5ba6d464113ad0c5812a9d24b539b86","relation":"main_file","creator":"slee","file_id":"20421","content_type":"application/pdf","embargo":"2026-10-03","date_created":"2025-10-03T12:29:25Z","access_level":"open_access","file_size":14587276,"file_name":"2025_Lee_Seungho_Thesis__.pdf"}],"_id":"20415","publication_status":"published","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"doi":"10.15479/AT-ISTA-20415"},{"corr_author":"1","acknowledgement":"Plant Facility,\r\nProtein Service Facility","keyword":["Auxin Signaling","Plant Development"],"date_created":"2025-09-19T12:23:38Z","language":[{"iso":"eng"}],"supervisor":[{"last_name":"Friml","full_name":"Friml, Jiří","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"file_date_updated":"2026-09-30T22:30:03Z","department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"MaLo"}],"title":"Nuclear and cell surface auxin signaling in A. thaliana developmental transitions","article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"author":[{"last_name":"Giannini","first_name":"Caterina","full_name":"Giannini, Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4"}],"date_updated":"2026-09-30T22:30:04Z","OA_place":"publisher","citation":{"mla":"Giannini, Caterina. <i>Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>.","ama":"Giannini C. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>","apa":"Giannini, C. (2025). <i>Nuclear and cell surface auxin signaling in A. thaliana developmental transitions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>","short":"C. Giannini, Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions, Institute of Science and Technology Austria, 2025.","ista":"Giannini C. 2025. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria.","chicago":"Giannini, Caterina. “Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>.","ieee":"C. Giannini, “Nuclear and cell surface auxin signaling in A. thaliana developmental transitions,” Institute of Science and Technology Austria, 2025."},"date_published":"2025-09-19T00:00:00Z","ddc":["580"],"degree_awarded":"PhD","month":"09","related_material":{"record":[{"relation":"part_of_dissertation","id":"12291","status":"public"},{"id":"19399","status":"public","relation":"part_of_dissertation"}]},"page":"151","year":"2025","type":"dissertation","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","day":"19","fulldoi":"https://doi.org/10.15479/AT-ISTA-20364","status":"public","has_accepted_license":"1","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"file_name":"2025_Giannini_Caterina_Thesis...pdf","access_level":"open_access","file_size":14278965,"date_created":"2025-09-24T14:46:34Z","embargo":"2026-09-30","content_type":"application/pdf","file_id":"20390","creator":"cgiannin","checksum":"536ba1701453b0b2346be14c046b2911","date_updated":"2026-09-30T22:30:03Z","relation":"main_file"},{"date_created":"2025-09-24T14:46:35Z","file_name":"2025_Giannini_Caterina_Thesis...docx","file_size":24499022,"access_level":"closed","creator":"cgiannin","embargo_to":"open_access","date_updated":"2026-09-30T22:30:03Z","relation":"source_file","checksum":"192f55262f2da2ea0a59d9c23a1b8573","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"20391"}],"alternative_title":["ISTA Thesis"],"oa":1,"doi":"10.15479/AT-ISTA-20364","_id":"20364","publication_status":"published"},{"has_accepted_license":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-20393","status":"public","year":"2025","type":"dissertation","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","day":"24","doi":"10.15479/AT-ISTA-20393","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"_id":"20393","publication_status":"published","file":[{"file_id":"20413","content_type":"application/x-zip-compressed","embargo_to":"open_access","creator":"kkishi","date_updated":"2026-09-30T22:30:04Z","checksum":"6bb5a7ce318dc3f7bd165f2523e77b89","relation":"source_file","file_name":"2025-Kishi-Kasumi-Thesis.zip","access_level":"closed","file_size":41847994,"date_created":"2025-09-30T14:33:17Z"},{"file_size":55747072,"access_level":"open_access","file_name":"2025-Kishi-Kasumi-Thesis.pdf","date_created":"2025-09-30T14:33:22Z","content_type":"application/pdf","file_id":"20414","embargo":"2026-09-30","relation":"main_file","date_updated":"2026-09-30T22:30:04Z","checksum":"88349b9177e1dcbe1242cd3884b36fdb","creator":"kkishi"}],"oa":1,"alternative_title":["ISTA Thesis"],"department":[{"_id":"GradSch"},{"_id":"AnKi"},{"_id":"EdHa"}],"file_date_updated":"2026-09-30T22:30:04Z","title":"Regulation of notochord and floor plate size during mouse development","article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-09-25T10:08:10Z","supervisor":[{"orcid":"0000-0003-4509-4998","first_name":"Anna","full_name":"Kicheva, Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo"}],"language":[{"iso":"eng"}],"corr_author":"1","degree_awarded":"PhD","related_material":{"record":[{"id":"18481","status":"public","relation":"part_of_dissertation"}]},"month":"09","page":"102","date_published":"2025-09-24T00:00:00Z","ddc":["570"],"OA_place":"publisher","citation":{"ieee":"K. Kishi, “Regulation of notochord and floor plate size during mouse development,” Institute of Science and Technology Austria, 2025.","ista":"Kishi K. 2025. Regulation of notochord and floor plate size during mouse development. Institute of Science and Technology Austria.","chicago":"Kishi, Kasumi. “Regulation of Notochord and Floor Plate Size during Mouse Development.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20393\">https://doi.org/10.15479/AT-ISTA-20393</a>.","short":"K. Kishi, Regulation of Notochord and Floor Plate Size during Mouse Development, Institute of Science and Technology Austria, 2025.","apa":"Kishi, K. (2025). <i>Regulation of notochord and floor plate size during mouse development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20393\">https://doi.org/10.15479/AT-ISTA-20393</a>","ama":"Kishi K. Regulation of notochord and floor plate size during mouse development. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20393\">10.15479/AT-ISTA-20393</a>","mla":"Kishi, Kasumi. <i>Regulation of Notochord and Floor Plate Size during Mouse Development</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20393\">10.15479/AT-ISTA-20393</a>."},"author":[{"full_name":"Kishi, Kasumi","first_name":"Kasumi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6060-4795","last_name":"Kishi"}],"date_updated":"2026-09-30T22:30:05Z"},{"article_type":"original","external_id":{"pmid":["40782342"],"isi":["001547884300001"]},"acknowledgement":"We gratefully acknowledge the Imaging and Optics, Electron Microscopy (especially Vanessa Zheden for technical assistance) and Life Science (in particular Dorota Jaworska) facilities at ISTA for their continuous support. Authors would like to thank Michelle Gallei for advice during the generation of the transgenic lines; Zuzana Gelová for advice with DR5rev::GFP analyses; Ivan Kulich for help and advice on trichome imaging; Aline Monzer for generous help with hypocotyl and root analyses; Shutang Tan for help with the NGS data analysis; and Milan Župunski for advice on abiotic stress experiments. We would like to thank Dolf Weijers for the SOSEKI (SOK) marker line seeds. This work has benefited from the support of IJPB's Plant Observatory platforms P0-Chem.\r\n\r\nThis work was supported by Austrian Science Fund (FWF) (I 6123-B) and Science and Technology Department of Jiangxi Province (20223BCJ25037) to Huibin Han. The IJPB benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).","corr_author":"1","publication_identifier":{"issn":["0960-7412"],"eissn":["1365-313X"]},"scopus_import":"1","department":[{"_id":"EvBe"},{"_id":"JiFr"},{"_id":"GradSch"}],"file_date_updated":"2025-09-01T14:09:31Z","article_processing_charge":"Yes (via OA deal)","title":"Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development","date_created":"2025-08-17T22:01:36Z","language":[{"iso":"eng"}],"citation":{"mla":"Babic, David, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>, vol. 123, no. 3, e70396, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>.","ama":"Babic D, Abualia R, Fiedler L, et al. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. 2025;123(3). doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>","apa":"Babic, D., Abualia, R., Fiedler, L., Qi, L., Tellier, F., Smoljan, A., … Friml, J. (2025). Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>","short":"D. Babic, R. Abualia, L. Fiedler, L. Qi, F. Tellier, A. Smoljan, H. Rakusova, P. Valošek, H. Han, E. Benková, J.D. Faure, J. Friml, Plant Journal 123 (2025).","chicago":"Babic, David, Rashed Abualia, Lukas Fiedler, Linlin Qi, Frédérique Tellier, Adrijana Smoljan, Hana Rakusova, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>.","ista":"Babic D, Abualia R, Fiedler L, Qi L, Tellier F, Smoljan A, Rakusova H, Valošek P, Han H, Benková E, Faure JD, Friml J. 2025. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. 123(3), e70396.","ieee":"D. Babic <i>et al.</i>, “Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development,” <i>Plant Journal</i>, vol. 123, no. 3. Wiley, 2025."},"OA_place":"publisher","issue":"3","date_updated":"2026-10-03T22:30:12Z","author":[{"last_name":"Babic","id":"db566d23-f6e0-11ea-865d-e6f270e968e7","first_name":"David","full_name":"Babic, David"},{"orcid":"0000-0002-9357-9415","first_name":"Rashed","id":"4827E134-F248-11E8-B48F-1D18A9856A87","full_name":"Abualia, Rashed","last_name":"Abualia"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","first_name":"Lukas","full_name":"Fiedler, Lukas","last_name":"Fiedler"},{"last_name":"Qi","orcid":"0000-0001-5187-8401","id":"44B04502-A9ED-11E9-B6FC-583AE6697425","full_name":"Qi, Linlin","first_name":"Linlin"},{"full_name":"Tellier, Frédérique","first_name":"Frédérique","last_name":"Tellier"},{"first_name":"Adrijana","full_name":"Smoljan, Adrijana","id":"cced8a85-223e-11ed-af04-b0596c55053b","last_name":"Smoljan"},{"last_name":"Rakusova","id":"4CAAA450-78D2-11EA-8E57-B40A396E08BA","full_name":"Rakusova, Hana","first_name":"Hana"},{"last_name":"Valošek","full_name":"Valošek, Petr","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87","first_name":"Petr"},{"last_name":"Han","first_name":"Huibin","full_name":"Han, Huibin","id":"31435098-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739"},{"full_name":"Faure, Jean Denis","first_name":"Jean Denis","last_name":"Faure"},{"orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"related_material":{"record":[{"id":"20362","status":"public","relation":"dissertation_contains"}]},"PlanS_conform":"1","month":"08","date_published":"2025-08-01T00:00:00Z","ddc":["580"],"fulldoi":"https://doi.org/10.1111/tpj.70396","article_number":"e70396","OA_type":"hybrid","status":"public","intvolume":"       123","day":"01","type":"journal_article","year":"2025","oa_version":"Published Version","publisher":"Wiley","isi":1,"pmid":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","has_accepted_license":"1","volume":123,"quality_controlled":"1","file":[{"creator":"dernst","checksum":"1cdc3341d2d23101abca72521f1f23cb","relation":"main_file","date_updated":"2025-09-01T14:09:31Z","success":1,"file_id":"20264","content_type":"application/pdf","date_created":"2025-09-01T14:09:31Z","file_name":"2025_PlantJournal_Babic.pdf","file_size":5791111,"access_level":"open_access"}],"oa":1,"publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"_id":"20187","publication":"Plant Journal","doi":"10.1111/tpj.70396","abstract":[{"text":"Very long-chain fatty acids (VLCFAs), being constituents of different types of lipids, are critical factors in plant development, presumably due to their impact on the endomembrane system. The VLCFAs are synthesized in the endoplasmic reticulum by a heterotetrameric enzymatic complex including β-ketoacyl CoA reductase 1 (KCR1), whose mutant is lethal. Here, we describe the ectopic shoot meristems (esm) mutant, a viable kcr1 allele presumably affecting surface properties of the KCR1 protein. This kcr1-2 mutant shows reduced fatty acyl elongation that impacts VLCFAs. The kcr1-2 plants show severe defects during different stages of development, which all correlate with defects in polar localization and subcellular trafficking of PIN auxin transporters and resulting asymmetric auxin distribution. Detailed analysis of KCR1 expression and patterning defects in kcr1-2 suggests that KCR1 plays a role in delineating boundaries around meristematic and specialized differentiating tissues, including root and shoot meristems, initiating lateral roots, lateral root primordia, and trichomes. In these contexts, KCR1-produced VLCFAs may act in a non-cell-autonomous manner. Viable kcr1-2 represents a useful tool to study VLCFA roles in plant development and highlights VLCFAs as critical developmental factors at the interface of cell polarity and tissue development.","lang":"eng"}],"project":[{"_id":"bd76d395-d553-11ed-ba76-f678c14f9033","grant_number":"I06123","name":"Peptide receptors for auxin canalization in Arabidopsis"}]},{"file":[{"embargo":"2026-09-25","content_type":"application/pdf","file_id":"20388","date_updated":"2026-09-25T22:30:02Z","relation":"main_file","checksum":"5ecf274281a54a41e0288bc79edf7492","creator":"dbabic","file_size":7501548,"access_level":"open_access","file_name":"2025_David_Babic_Thesis.pdf","date_created":"2025-09-24T13:43:14Z"},{"access_level":"closed","file_size":23206052,"file_name":"Thesis_Babic_draft.docx","date_created":"2025-09-24T13:43:14Z","file_id":"20389","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","checksum":"2703e548390de0a1af7a707137e8ab3b","relation":"source_file","date_updated":"2026-09-25T22:30:02Z","creator":"dbabic","embargo_to":"open_access"}],"oa":1,"alternative_title":["ISTA Thesis"],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"_id":"20362","publication_status":"published","doi":"10.15479/AT-ISTA-20362","day":"18","year":"2025","type":"dissertation","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","fulldoi":"https://doi.org/10.15479/AT-ISTA-20362","status":"public","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"has_accepted_license":"1","date_updated":"2026-09-25T22:30:03Z","author":[{"id":"db566d23-f6e0-11ea-865d-e6f270e968e7","full_name":"Babic, David","first_name":"David","last_name":"Babic"}],"citation":{"ama":"Babic D. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20362\">10.15479/AT-ISTA-20362</a>","mla":"Babic, David. <i>Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20362\">10.15479/AT-ISTA-20362</a>.","apa":"Babic, D. (2025). <i>Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20362\">https://doi.org/10.15479/AT-ISTA-20362</a>","short":"D. Babic, Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana, Institute of Science and Technology Austria, 2025.","chicago":"Babic, David. “Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20362\">https://doi.org/10.15479/AT-ISTA-20362</a>.","ista":"Babic D. 2025. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. Institute of Science and Technology Austria.","ieee":"D. Babic, “Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana,” Institute of Science and Technology Austria, 2025."},"OA_place":"publisher","date_published":"2025-09-18T00:00:00Z","ddc":["580"],"month":"09","related_material":{"record":[{"status":"public","id":"20187","relation":"part_of_dissertation"}]},"page":"116","degree_awarded":"PhD","corr_author":"1","date_created":"2025-09-17T13:28:01Z","supervisor":[{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"},{"orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","last_name":"Benková"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2026-09-25T22:30:02Z","department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"EvBe"}],"title":"Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana","article_processing_charge":"No"},{"date_published":"2025-09-25T00:00:00Z","ddc":["539","570"],"related_material":{"record":[{"relation":"research_data","status":"public","id":"21439"},{"relation":"dissertation_contains","status":"public","id":"21423"}]},"month":"09","das_tickbox":"1","date_updated":"2026-10-03T22:30:19Z","author":[{"full_name":"Dunajova, Zuzana","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","first_name":"Zuzana","last_name":"Dunajova"},{"orcid":"0000-0003-1671-393X","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","full_name":"Tasciyan, Saren","first_name":"Saren","last_name":"Tasciyan"},{"first_name":"Juraj","id":"3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1","full_name":"Majek, Juraj","last_name":"Majek"},{"last_name":"Merrin","first_name":"Jack","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5145-4609"},{"last_name":"Sahai","full_name":"Sahai, Erik","first_name":"Erik"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt"},{"last_name":"Hannezo","orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"citation":{"ama":"Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>","mla":"Dunajova, Zuzana, et al. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>.","apa":"Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K., &#38; Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>","short":"Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B. Hannezo, BioRxiv (n.d.).","ieee":"Z. Dunajova <i>et al.</i>, “Substrate heterogeneity promotes cancer cell dissemination through interface roughening,” <i>bioRxiv</i>. .","chicago":"Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>.","ista":"Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv, <a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>."},"OA_place":"repository","date_created":"2026-03-11T08:40:06Z","language":[{"iso":"eng"}],"department":[{"_id":"GradSch"},{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"AnSa"}],"title":"Substrate heterogeneity promotes cancer cell dissemination through interface roughening","article_processing_charge":"No","acknowledgement":"European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian Academy of Sciences, 26360","corr_author":"1","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"_id":"21427","publication_status":"draft","publication":"bioRxiv","abstract":[{"text":"While tumor malignancy has been extensively studied under the prism of genetic and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal interactions with the microenvironment. This raises the hitherto untested possibility that heterogeneity of the untransformed tumor stroma can actively fuel malignant progression. As biological heterogeneity is inherently difficult to control, we adopted a reductionist approach and let tumor cells invade micro-engineered environments harboring obstacles with precision-controlled geometry. We find that not only the presence of obstacles, but more surprisingly their spatial disorder, causes a drastic shift from a collective to a single-cell mode of invasion – comparable in strength to cadherin loss. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell detachments result both from local geometrical constraints and a global integration of spatial disorder over time. We show that different types of microenvironments map onto different universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang (KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with quenched disorder (KPZq). Our findings highlight generic physical principles for how the mode of cancer cell invasion depends on environmental heterogeneity, with potential implications to understand tumor evolution in vivo.","lang":"eng"}],"doi":"10.1101/2025.05.20.655037","project":[{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"},{"_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d","name":"Motile active matter models of migrating cells and chiral filaments","grant_number":"26360"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","day":"25","main_file_link":[{"url":"https://doi.org/10.1101/2025.05.20.655037","open_access":"1"}],"year":"2025","type":"preprint","oa_version":"Preprint","fulldoi":"https://doi.org/10.1101/2025.05.20.655037","status":"public"}]