[{"status":"public","keyword":["Human mediator complex","MED11","MEDopathies"],"issue":"10","ddc":["570"],"article_type":"original","month":"10","oa_version":"Published Version","quality_controlled":"1","doi":"10.1016/j.gim.2022.07.013","license":"https://creativecommons.org/licenses/by/4.0/","publisher":"Elsevier","volume":24,"author":[{"last_name":"Cali","full_name":"Cali, Elisa","first_name":"Elisa"},{"first_name":"Sheng-Jia","full_name":"Lin, Sheng-Jia","last_name":"Lin"},{"first_name":"Clarissa","last_name":"Rocca","full_name":"Rocca, Clarissa"},{"last_name":"Sahin","full_name":"Sahin, Yavuz","first_name":"Yavuz"},{"full_name":"Al Shamsi, Aisha","last_name":"Al Shamsi","first_name":"Aisha"},{"first_name":"Salima","full_name":"El Chehadeh, Salima","last_name":"El Chehadeh"},{"full_name":"Chaabouni, Myriam","last_name":"Chaabouni","first_name":"Myriam"},{"last_name":"Mankad","full_name":"Mankad, Kshitij","first_name":"Kshitij"},{"first_name":"Evangelia","full_name":"Galanaki, Evangelia","last_name":"Galanaki"},{"first_name":"Stephanie","last_name":"Efthymiou","full_name":"Efthymiou, Stephanie"},{"first_name":"Sniya","full_name":"Sudhakar, Sniya","last_name":"Sudhakar"},{"first_name":"Alkyoni","full_name":"Athanasiou-Fragkouli, Alkyoni","last_name":"Athanasiou-Fragkouli"},{"full_name":"Celik, Tamer","last_name":"Celik","first_name":"Tamer"},{"first_name":"Nejat","last_name":"Narli","full_name":"Narli, Nejat"},{"first_name":"Sebastiano","last_name":"Bianca","full_name":"Bianca, Sebastiano"},{"first_name":"David","last_name":"Murphy","full_name":"Murphy, David"},{"full_name":"Moreira, Francisco Martins De Carvalho","last_name":"Moreira","first_name":"Francisco Martins De Carvalho"},{"first_name":"Andrea","full_name":"Accogli, Andrea","last_name":"Accogli"},{"first_name":"Cassidy","last_name":"Petree","full_name":"Petree, Cassidy"},{"orcid":"0000-0002-2512-7812","id":"3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3","first_name":"Kevin","last_name":"Huang","full_name":"Huang, Kevin"},{"first_name":"Kamel","full_name":"Monastiri, Kamel","last_name":"Monastiri"},{"first_name":"Masoud","last_name":"Edizadeh","full_name":"Edizadeh, Masoud"},{"first_name":"Rosaria","last_name":"Nardello","full_name":"Nardello, Rosaria"},{"last_name":"Ognibene","full_name":"Ognibene, Marzia","first_name":"Marzia"},{"last_name":"De Marco","full_name":"De Marco, Patrizia","first_name":"Patrizia"},{"first_name":"Martino","full_name":"Ruggieri, Martino","last_name":"Ruggieri"},{"first_name":"Federico","last_name":"Zara","full_name":"Zara, Federico"},{"first_name":"Pasquale","full_name":"Striano, Pasquale","last_name":"Striano"},{"last_name":"Sahin","full_name":"Sahin, Yavuz","first_name":"Yavuz"},{"last_name":"Al-Gazali","full_name":"Al-Gazali, Lihadh","first_name":"Lihadh"},{"first_name":"Marie Therese Abi","full_name":"Warde, Marie Therese Abi","last_name":"Warde"},{"first_name":"Benedicte","full_name":"Gerard, Benedicte","last_name":"Gerard"},{"last_name":"Zifarelli","full_name":"Zifarelli, Giovanni","first_name":"Giovanni"},{"full_name":"Beetz, Christian","last_name":"Beetz","first_name":"Christian"},{"first_name":"Sara","last_name":"Fortuna","full_name":"Fortuna, Sara"},{"first_name":"Miguel","full_name":"Soler, Miguel","last_name":"Soler"},{"first_name":"Enza Maria","last_name":"Valente","full_name":"Valente, Enza Maria"},{"first_name":"Gaurav","last_name":"Varshney","full_name":"Varshney, Gaurav"},{"last_name":"Maroofian","full_name":"Maroofian, Reza","first_name":"Reza"},{"first_name":"Vincenzo","full_name":"Salpietro, Vincenzo","last_name":"Salpietro"},{"full_name":"Houlden, Henry","last_name":"Houlden","first_name":"Henry"},{"full_name":"Grp, SYNaPS Study","last_name":"Grp","first_name":"SYNaPS Study"}],"day":"01","scopus_import":"1","citation":{"ieee":"E. Cali <i>et al.</i>, “A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease,” <i>Genetics in Medicine</i>, vol. 24, no. 10. Elsevier, pp. 2194–2203, 2022.","apa":"Cali, E., Lin, S.-J., Rocca, C., Sahin, Y., Al Shamsi, A., El Chehadeh, S., … Grp, Syn. S. (2022). A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. <i>Genetics in Medicine</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">https://doi.org/10.1016/j.gim.2022.07.013</a>","short":"E. Cali, S.-J. Lin, C. Rocca, Y. Sahin, A. Al Shamsi, S. El Chehadeh, M. Chaabouni, K. Mankad, E. Galanaki, S. Efthymiou, S. Sudhakar, A. Athanasiou-Fragkouli, T. Celik, N. Narli, S. Bianca, D. Murphy, F.M.D.C. Moreira, A. Accogli, C. Petree, K. Huang, K. Monastiri, M. Edizadeh, R. Nardello, M. Ognibene, P. De Marco, M. Ruggieri, F. Zara, P. Striano, Y. Sahin, L. Al-Gazali, M.T.A. Warde, B. Gerard, G. Zifarelli, C. Beetz, S. Fortuna, M. Soler, E.M. Valente, G. Varshney, R. Maroofian, V. Salpietro, H. Houlden, Syn.S. Grp, Genetics in Medicine 24 (2022) 2194–2203.","ista":"Cali E, Lin S-J, Rocca C, Sahin Y, Al Shamsi A, El Chehadeh S, Chaabouni M, Mankad K, Galanaki E, Efthymiou S, Sudhakar S, Athanasiou-Fragkouli A, Celik T, Narli N, Bianca S, Murphy D, Moreira FMDC, Accogli A, Petree C, Huang K, Monastiri K, Edizadeh M, Nardello R, Ognibene M, De Marco P, Ruggieri M, Zara F, Striano P, Sahin Y, Al-Gazali L, Warde MTA, Gerard B, Zifarelli G, Beetz C, Fortuna S, Soler M, Valente EM, Varshney G, Maroofian R, Salpietro V, Houlden H, Grp SynS. 2022. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genetics in Medicine. 24(10), 2194–2203.","ama":"Cali E, Lin S-J, Rocca C, et al. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. <i>Genetics in Medicine</i>. 2022;24(10):2194-2203. doi:<a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">10.1016/j.gim.2022.07.013</a>","mla":"Cali, Elisa, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” <i>Genetics in Medicine</i>, vol. 24, no. 10, Elsevier, 2022, pp. 2194–203, doi:<a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">10.1016/j.gim.2022.07.013</a>.","chicago":"Cali, Elisa, Sheng-Jia Lin, Clarissa Rocca, Yavuz Sahin, Aisha Al Shamsi, Salima El Chehadeh, Myriam Chaabouni, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” <i>Genetics in Medicine</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">https://doi.org/10.1016/j.gim.2022.07.013</a>."},"file":[{"content_type":"application/pdf","date_created":"2023-09-25T08:56:06Z","file_id":"14371","date_updated":"2023-09-25T08:56:06Z","file_name":"2022_GeneticsMedicine_Calin.pdf","file_size":1434037,"relation":"main_file","access_level":"open_access","checksum":"8117175a89129eb5022d81ffe7625f9f","success":1,"creator":"dernst"}],"publication_status":"published","page":"2194-2203","type":"journal_article","_id":"14355","has_accepted_license":"1","intvolume":"        24","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease","article_processing_charge":"No","date_published":"2022-10-01T00:00:00Z","language":[{"iso":"eng"}],"file_date_updated":"2023-09-25T08:56:06Z","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"GradSch"}],"extern":"1","abstract":[{"text":"Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the candidate variant on both MED11 RNA and protein was assessed using reverse transcriptase polymerase chain reaction and western blotting using fibroblast cell lines derived from 1 affected individual and controls and through computational approaches. Knockouts in zebrafish were generated using clustered regularly interspaced short palindromic repeats/Cas9. Results: The disease was characterized by microcephaly, profound neurodevelopmental impairment, exaggerated startle response, myoclonic seizures, progressive widespread neurodegeneration, and premature death. Functional studies on patient-derived fibroblasts did not show a loss of protein function but rather disruption of the C-terminal of MED11, likely impairing binding to other MED subunits. A zebrafish knockout model recapitulates key clinical phenotypes. Conclusion: Loss of the C-terminal of MED subunit 11 may affect its binding efficiency to other MED subunits, thus implicating the MED-complex stability in brain development and neurodegeneration. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics.","lang":"eng"}],"publication_identifier":{"issn":["1098-3600"]},"date_updated":"2023-09-25T08:57:07Z","year":"2022","date_created":"2023-09-20T20:57:18Z","publication":"Genetics in Medicine"},{"date_created":"2024-06-23T15:01:27Z","publication":"arXiv","date_updated":"2026-04-07T12:55:46Z","year":"2022","publication_status":"draft","arxiv":1,"citation":{"mla":"Hausel, Tamás, and Kamil P. Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” <i>ArXiv</i>, 2212.11836, doi:<a href=\"https://doi.org/10.48550/arXiv.2212.11836\">10.48550/arXiv.2212.11836</a>.","ama":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2212.11836\">10.48550/arXiv.2212.11836</a>","ista":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. arXiv, 2212.11836.","chicago":"Hausel, Tamás, and Kamil P Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2212.11836\">https://doi.org/10.48550/arXiv.2212.11836</a>.","apa":"Hausel, T., &#38; Rychlewicz, K. P. (n.d.). Spectrum of equivariant cohomology as a fixed point scheme. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2212.11836\">https://doi.org/10.48550/arXiv.2212.11836</a>","short":"T. Hausel, K.P. Rychlewicz, ArXiv (n.d.).","ieee":"T. Hausel and K. P. Rychlewicz, “Spectrum of equivariant cohomology as a fixed point scheme,” <i>arXiv</i>. ."},"external_id":{"arxiv":["2212.11836"]},"abstract":[{"text":"An action of a complex reductive group G on a smooth projective variety X is regular when all regular unipotent elements in G act with finitely many fixed points. Then the complex G-equivariant cohomology ring of X is isomorphic to the coordinate ring of a certain regular fixed point scheme. Examples include partial flag varieties, smooth Schubert varieties and Bott-Samelson varieties. We also show that a more general version of the fixed point scheme allows a generalisation to GKM spaces, such as toric varieties.","lang":"eng"}],"day":"22","department":[{"_id":"GradSch"},{"_id":"TaHa"}],"related_material":{"record":[{"id":"19071","status":"public","relation":"later_version"},{"status":"public","relation":"dissertation_contains","id":"17156"}]},"author":[{"full_name":"Hausel, Tamás","last_name":"Hausel","orcid":"0000-0002-9582-2634","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","first_name":"Tamás"},{"full_name":"Rychlewicz, Kamil P","last_name":"Rychlewicz","first_name":"Kamil P","id":"85A07246-A8BF-11E9-B4FA-D9E3E5697425"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"language":[{"iso":"eng"}],"OA_place":"repository","doi":"10.48550/arXiv.2212.11836","date_published":"2022-12-22T00:00:00Z","article_processing_charge":"No","title":"Spectrum of equivariant cohomology as a fixed point scheme","oa_version":"Preprint","month":"12","article_number":"2212.11836","_id":"17157","type":"preprint","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2212.11836"}]},{"ec_funded":1,"scopus_import":"1","isi":1,"citation":{"ama":"Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. <i>Journal of Mathematical Physics</i>. 2022;63(1). doi:<a href=\"https://doi.org/10.1063/5.0051632\">10.1063/5.0051632</a>","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Uniform Gap.” <i>Journal of Mathematical Physics</i>, vol. 63, no. 1, 011901, AIP Publishing, 2022, doi:<a href=\"https://doi.org/10.1063/5.0051632\">10.1063/5.0051632</a>.","chicago":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Uniform Gap.” <i>Journal of Mathematical Physics</i>. AIP Publishing, 2022. <a href=\"https://doi.org/10.1063/5.0051632\">https://doi.org/10.1063/5.0051632</a>.","ista":"Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. Journal of Mathematical Physics. 63(1), 011901.","apa":"Henheik, S. J., &#38; Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. <i>Journal of Mathematical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0051632\">https://doi.org/10.1063/5.0051632</a>","short":"S.J. Henheik, S. Teufel, Journal of Mathematical Physics 63 (2022).","ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap,” <i>Journal of Mathematical Physics</i>, vol. 63, no. 1. AIP Publishing, 2022."},"publication_status":"published","publisher":"AIP Publishing","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"volume":63,"author":[{"full_name":"Henheik, Sven Joscha","last_name":"Henheik","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","first_name":"Sven Joscha","orcid":"0000-0003-1106-327X"},{"first_name":"Stefan","full_name":"Teufel, Stefan","last_name":"Teufel"}],"day":"03","doi":"10.1063/5.0051632","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2012.15238"}],"status":"public","keyword":["mathematical physics","statistical and nonlinear physics"],"article_number":"011901","issue":"1","article_type":"original","month":"01","oa_version":"Preprint","abstract":[{"text":"We show that recent results on adiabatic theory for interacting gapped many-body systems on finite lattices remain valid in the thermodynamic limit. More precisely, we prove a generalized super-adiabatic theorem for the automorphism group describing the infinite volume dynamics on the quasi-local algebra of observables. The key assumption is the existence of a sequence of gapped finite volume Hamiltonians, which generates the same infinite volume dynamics in the thermodynamic limit. Our adiabatic theorem also holds for certain perturbations of gapped ground states that close the spectral gap (so it is also an adiabatic theorem for resonances and, in this sense, “generalized”), and it provides an adiabatic approximation to all orders in the adiabatic parameter (a property often called “super-adiabatic”). In addition to the existing results for finite lattices, we also perform a resummation of the adiabatic expansion and allow for observables that are not strictly local. Finally, as an application, we prove the validity of linear and higher order response theory for our class of perturbations for infinite systems. While we consider the result and its proof as new and interesting in itself, we also lay the foundation for the proof of an adiabatic theorem for systems with a gap only in the bulk, which will be presented in a follow-up article.","lang":"eng"}],"external_id":{"arxiv":["2012.15238"],"isi":["000739446000009"]},"acknowledgement":"J.H. acknowledges partial financial support from ERC Advanced Grant “RMTBeyond” No. 101020331.","publication_identifier":{"eissn":["1089-7658"],"issn":["0022-2488"]},"arxiv":1,"date_updated":"2025-04-14T07:57:17Z","year":"2022","publication":"Journal of Mathematical Physics","date_created":"2022-01-03T12:19:48Z","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"article_processing_charge":"No","title":"Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap","date_published":"2022-01-03T00:00:00Z","language":[{"iso":"eng"}],"_id":"10600","type":"journal_article","intvolume":"        63"},{"publication_identifier":{"eissn":["1572-9656"],"issn":["1385-0172"]},"arxiv":1,"acknowledgement":"I am very grateful to Robert Seiringer for his guidance during this project and for many valuable comments on an earlier version of the manuscript. Moreover, I would like to thank Asbjørn Bækgaard Lauritsen for many helpful discussions and comments, pointing out the reference [22] and for his involvement in a closely related joint project [13]. Finally, I am grateful to Christian Hainzl for valuable comments on an earlier version of the manuscript and Andreas Deuchert for interesting discussions.","date_created":"2022-01-13T15:40:53Z","publication":"Mathematical Physics, Analysis and Geometry","date_updated":"2026-04-07T12:37:10Z","year":"2022","abstract":[{"lang":"eng","text":"We investigate the BCS critical temperature Tc in the high-density limit and derive an asymptotic formula, which strongly depends on the behavior of the interaction potential V on the Fermi-surface. Our results include a rigorous confirmation for the behavior of Tc at high densities proposed by Langmann et al. (Phys Rev Lett 122:157001, 2019) and identify precise conditions under which superconducting domes arise in BCS theory."}],"external_id":{"arxiv":["2106.02015"],"isi":["000741387600001"]},"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","corr_author":"1","oa":1,"file_date_updated":"2022-01-14T07:27:45Z","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","title":"The BCS critical temperature at high density","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_published":"2022-01-11T00:00:00Z","intvolume":"        25","type":"journal_article","_id":"10623","has_accepted_license":"1","file":[{"creator":"cchlebak","checksum":"d44f8123a52592a75b2c3b8ee2cd2435","success":1,"file_name":"2022_MathPhyAnalGeo_Henheik.pdf","relation":"main_file","file_size":505804,"access_level":"open_access","content_type":"application/pdf","date_updated":"2022-01-14T07:27:45Z","file_id":"10624","date_created":"2022-01-14T07:27:45Z"}],"isi":1,"citation":{"ieee":"S. J. Henheik, “The BCS critical temperature at high density,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 25, no. 1. Springer Nature, 2022.","ama":"Henheik SJ. The BCS critical temperature at high density. <i>Mathematical Physics, Analysis and Geometry</i>. 2022;25(1). doi:<a href=\"https://doi.org/10.1007/s11040-021-09415-0\">10.1007/s11040-021-09415-0</a>","ista":"Henheik SJ. 2022. The BCS critical temperature at high density. Mathematical Physics, Analysis and Geometry. 25(1), 3.","mla":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 25, no. 1, 3, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s11040-021-09415-0\">10.1007/s11040-021-09415-0</a>.","chicago":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s11040-021-09415-0\">https://doi.org/10.1007/s11040-021-09415-0</a>.","short":"S.J. Henheik, Mathematical Physics, Analysis and Geometry 25 (2022).","apa":"Henheik, S. J. (2022). The BCS critical temperature at high density. <i>Mathematical Physics, Analysis and Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11040-021-09415-0\">https://doi.org/10.1007/s11040-021-09415-0</a>"},"publication_status":"published","ec_funded":1,"scopus_import":"1","author":[{"id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","first_name":"Sven Joscha","orcid":"0000-0003-1106-327X","last_name":"Henheik","full_name":"Henheik, Sven Joscha"}],"day":"11","related_material":{"record":[{"id":"19540","status":"public","relation":"dissertation_contains"}]},"project":[{"grant_number":"101020331","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"publisher":"Springer Nature","volume":25,"quality_controlled":"1","doi":"10.1007/s11040-021-09415-0","month":"01","article_type":"original","oa_version":"Published Version","status":"public","issue":"1","ddc":["514"],"keyword":["geometry and topology","mathematical physics"],"article_number":"3"},{"article_number":"9","keyword":["mathematical physics","statistical and nonlinear physics"],"issue":"1","ddc":["530"],"status":"public","oa_version":"Published Version","article_type":"original","month":"01","quality_controlled":"1","doi":"10.1007/s11005-021-01494-y","volume":112,"publisher":"Springer Nature","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"19540"}]},"day":"18","author":[{"full_name":"Henheik, Sven Joscha","last_name":"Henheik","first_name":"Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","orcid":"0000-0003-1106-327X"},{"last_name":"Teufel","full_name":"Teufel, Stefan","first_name":"Stefan"},{"full_name":"Wessel, Tom","last_name":"Wessel","first_name":"Tom"}],"scopus_import":"1","ec_funded":1,"publication_status":"published","file":[{"file_name":"2022_LettersMathPhys_Henheik.pdf","file_size":357547,"relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_id":"10647","date_updated":"2022-01-19T09:41:14Z","date_created":"2022-01-19T09:41:14Z","creator":"cchlebak","checksum":"7e8e69b76e892c305071a4736131fe18","success":1}],"isi":1,"citation":{"short":"S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022).","apa":"Henheik, S. J., Teufel, S., &#38; Wessel, T. (2022). Local stability of ground states in locally gapped and weakly interacting quantum spin systems. <i>Letters in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11005-021-01494-y\">https://doi.org/10.1007/s11005-021-01494-y</a>","chicago":"Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” <i>Letters in Mathematical Physics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s11005-021-01494-y\">https://doi.org/10.1007/s11005-021-01494-y</a>.","ama":"Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. <i>Letters in Mathematical Physics</i>. 2022;112(1). doi:<a href=\"https://doi.org/10.1007/s11005-021-01494-y\">10.1007/s11005-021-01494-y</a>","mla":"Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” <i>Letters in Mathematical Physics</i>, vol. 112, no. 1, 9, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s11005-021-01494-y\">10.1007/s11005-021-01494-y</a>.","ista":"Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. Letters in Mathematical Physics. 112(1), 9.","ieee":"S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states in locally gapped and weakly interacting quantum spin systems,” <i>Letters in Mathematical Physics</i>, vol. 112, no. 1. Springer Nature, 2022."},"has_accepted_license":"1","_id":"10642","type":"journal_article","intvolume":"       112","date_published":"2022-01-18T00:00:00Z","pmid":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","title":"Local stability of ground states in locally gapped and weakly interacting quantum spin systems","file_date_updated":"2022-01-19T09:41:14Z","language":[{"iso":"eng"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"external_id":{"arxiv":["2106.13780"],"isi":["000744930400001"],"pmid":["35125630"]},"abstract":[{"lang":"eng","text":"Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized but otherwise arbitrary perturbations of weakly interacting quantum spin systems with uniformly gapped on-site terms change the ground state of such a system only locally, even if they close the spectral gap. We call this a strong version of the local perturbations perturb locally (LPPL) principle which is known to hold for much more general gapped systems, but only for perturbations that do not close the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle to Hamiltonians that have the appropriate structure of gapped on-site terms and weak interactions only locally in some region of space. While our results are technically corollaries to a theorem of Yarotsky, we expect that the paradigm of systems with a locally gapped ground state that is completely insensitive to the form of the Hamiltonian elsewhere extends to other situations and has important physical consequences."}],"year":"2022","date_updated":"2026-04-07T12:37:10Z","publication":"Letters in Mathematical Physics","date_created":"2022-01-18T16:18:25Z","acknowledgement":"J. H. acknowledges partial financial support by the ERC Advanced Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for very helpful comments and discussions and Jürg Fröhlich for references to the literature. Open Access funding enabled and organized by Projekt DEAL.","arxiv":1,"publication_identifier":{"issn":["0377-9017"],"eissn":["1573-0530"]}},{"file":[{"content_type":"application/pdf","date_updated":"2022-01-19T09:27:43Z","file_id":"10646","date_created":"2022-01-19T09:27:43Z","file_name":"2022_ForumMathSigma_Henheik.pdf","file_size":705323,"relation":"main_file","access_level":"open_access","checksum":"87592a755adcef22ea590a99dc728dd3","success":1,"creator":"cchlebak"}],"isi":1,"citation":{"chicago":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2022. <a href=\"https://doi.org/10.1017/fms.2021.80\">https://doi.org/10.1017/fms.2021.80</a>.","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” <i>Forum of Mathematics, Sigma</i>, vol. 10, e4, Cambridge University Press, 2022, doi:<a href=\"https://doi.org/10.1017/fms.2021.80\">10.1017/fms.2021.80</a>.","ista":"Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.","ama":"Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. <i>Forum of Mathematics, Sigma</i>. 2022;10. doi:<a href=\"https://doi.org/10.1017/fms.2021.80\">10.1017/fms.2021.80</a>","short":"S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).","apa":"Henheik, S. J., &#38; Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.80\">https://doi.org/10.1017/fms.2021.80</a>","ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk,” <i>Forum of Mathematics, Sigma</i>, vol. 10. Cambridge University Press, 2022."},"publication_status":"published","ec_funded":1,"scopus_import":"1","author":[{"orcid":"0000-0003-1106-327X","first_name":"Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","last_name":"Henheik"},{"first_name":"Stefan","full_name":"Teufel, Stefan","last_name":"Teufel"}],"day":"18","publisher":"Cambridge University Press","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"volume":10,"quality_controlled":"1","doi":"10.1017/fms.2021.80","article_type":"original","month":"01","oa_version":"Published Version","status":"public","keyword":["computational mathematics","discrete mathematics and combinatorics","geometry and topology","mathematical physics","statistics and probability","algebra and number theory","theoretical computer science","analysis"],"article_number":"e4","ddc":["510"],"acknowledgement":"J.H. acknowledges partial financial support by the ERC Advanced Grant ‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft and the Open Access Publishing Fund of the University of Tübingen is gratefully acknowledged.","publication_identifier":{"eissn":["2050-5094"]},"arxiv":1,"year":"2022","date_updated":"2025-04-14T07:57:17Z","publication":"Forum of Mathematics, Sigma","date_created":"2022-01-18T16:18:51Z","abstract":[{"lang":"eng","text":"We prove a generalised super-adiabatic theorem for extended fermionic systems assuming a spectral gap only in the bulk. More precisely, we assume that the infinite system has a unique ground state and that the corresponding Gelfand–Naimark–Segal Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that a similar adiabatic theorem also holds in the bulk of finite systems up to errors that vanish faster than any inverse power of the system size, although the corresponding finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n"}],"external_id":{"arxiv":["2012.15239"],"isi":["000743615000001"]},"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","corr_author":"1","file_date_updated":"2022-01-19T09:27:43Z","language":[{"iso":"eng"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"Yes","title":"Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk","date_published":"2022-01-18T00:00:00Z","intvolume":"        10","type":"journal_article","_id":"10643","has_accepted_license":"1"},{"intvolume":"       377","has_accepted_license":"1","_id":"10658","type":"journal_article","file_date_updated":"2022-01-24T10:34:45Z","language":[{"iso":"eng"}],"pmid":1,"date_published":"2022-01-24T00:00:00Z","title":"Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"GradSch"},{"_id":"NiBa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"publication":"Philosophical Transactions of the Royal Society B","date_created":"2022-01-24T10:34:53Z","year":"2022","date_updated":"2026-04-07T12:54:28Z","publication_identifier":{"issn":["0962-8436"],"eissn":["1471-2970"]},"acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) (grant no. P-32896B).","external_id":{"pmid":["35067097"],"isi":["000745854300008"]},"abstract":[{"lang":"eng","text":"We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’."}],"oa_version":"Published Version","month":"01","article_type":"original","ddc":["576"],"issue":"1846","article_number":"20210010","status":"public","doi":"10.1098/rstb.2021.0010","quality_controlled":"1","day":"24","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"14711"}],"link":[{"relation":"earlier_version","url":"https://doi.org/10.1101/2021.08.05.455207"}]},"author":[{"first_name":"Himani","last_name":"Sachdeva","full_name":"Sachdeva, Himani"},{"first_name":"Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1971-8314","last_name":"Olusanya","full_name":"Olusanya, Oluwafunmilola O"},{"last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"}],"volume":377,"project":[{"_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896","name":"Causes and consequences of population fragmentation"}],"publisher":"The Royal Society","publication_status":"published","citation":{"short":"H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the Royal Society B 377 (2022).","apa":"Sachdeva, H., Olusanya, O. O., &#38; Barton, N. H. (2022). Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>","chicago":"Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>.","ama":"Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. 2022;377(1846). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>","mla":"Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846, 20210010, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>.","ista":"Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 377(1846), 20210010.","ieee":"H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity,” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846. The Royal Society, 2022."},"file":[{"content_type":"application/pdf","date_created":"2022-01-24T10:34:45Z","file_id":"10659","date_updated":"2022-01-24T10:34:45Z","file_name":"rstb.2021.0010.pdf","relation":"main_file","access_level":"open_access","file_size":1845792,"checksum":"04ca9e2f0e344d680b947f2457df8d0a","creator":"oolusany"}],"isi":1,"scopus_import":"1"},{"OA_place":"publisher","doi":"10.15479/AT:ISTA:10727","oa_version":"Published Version","month":"02","ddc":["570"],"degree_awarded":"PhD","status":"public","alternative_title":["ISTA Thesis"],"publication_status":"published","file":[{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"10728","date_updated":"2023-02-03T23:30:03Z","date_created":"2022-02-04T15:36:12Z","file_name":"Thesis_Sina_Metzler.docx","file_size":6757886,"relation":"source_file","access_level":"closed","checksum":"47ba18bb270dd6cc266e0a3f7c69d0e4","creator":"smetzler","embargo_to":"open_access"},{"file_name":"Thesis_Sina_Metzler_A2.pdf","file_size":6314921,"relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_id":"10730","date_updated":"2023-02-03T23:30:03Z","date_created":"2022-02-04T15:36:43Z","creator":"smetzler","checksum":"f3ec07d5d6b20ae6e46bfeedebce9027","embargo":"2023-02-02"},{"creator":"smetzler","checksum":"dedd14b7be7a75d63018dbfc68dd8113","embargo":"2023-02-02","file_name":"Thesis_Sina_Metzler_print.pdf","access_level":"open_access","relation":"main_file","file_size":6882557,"content_type":"application/pdf","file_id":"10742","date_updated":"2023-02-04T23:30:03Z","date_created":"2022-02-07T10:35:02Z"}],"citation":{"ieee":"S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,” Institute of Science and Technology Austria, 2022.","chicago":"Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>.","ista":"Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant colonies. Institute of Science and Technology Austria.","ama":"Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>","mla":"Metzler, Sina. <i>Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>.","apa":"Metzler, S. (2022). <i>Pathogen-mediated sexual selection and immunization in ant colonies</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>","short":"S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies, Institute of Science and Technology Austria, 2022."},"ec_funded":1,"day":"07","author":[{"orcid":"0000-0002-9547-2494","first_name":"Sina","id":"48204546-F248-11E8-B48F-1D18A9856A87","last_name":"Metzler","full_name":"Metzler, Sina"}],"publisher":"Institute of Science and Technology Austria","project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","grant_number":"771402","call_identifier":"H2020","name":"Epidemics in ant societies on a chip"}],"file_date_updated":"2023-02-04T23:30:03Z","language":[{"iso":"eng"}],"date_published":"2022-02-07T00:00:00Z","article_processing_charge":"No","title":"Pathogen-mediated sexual selection and immunization in ant colonies","has_accepted_license":"1","_id":"10727","type":"dissertation","acknowledged_ssus":[{"_id":"LifeSc"}],"date_created":"2022-02-04T15:45:12Z","date_updated":"2026-04-07T14:30:18Z","year":"2022","publication_identifier":{"issn":["2663-337X"]},"abstract":[{"lang":"eng","text":"Social insects are a common model to study disease dynamics in social animals. Even though pathogens should thrive in social insect colonies as the hosts engage in frequent social interactions, are closely related and live in a pathogen-rich environment, disease outbreaks are rare. This is because social insects have evolved mechanisms to keep pathogens at bay – and fight disease as a collective. Social insect colonies are often viewed as “superorganisms” with division of labor between reproductive “germ-like” queens and males and “somatic” workers, which together form an interdependent reproductive unit that parallels a multicellular body. Superorganisms possess a “social immune system” that comprises of collective disease defenses performed by the workers - summarized as “social immunity”. In social groups immunization (reduced susceptibility to a parasite upon secondary exposure to the same parasite) can e.g. be triggered by social interactions (“social immunization”). Social immunization can be caused by (i) asymptomatic low-level infections that are acquired during caregiving to a contagious individual that can give an immune boost, which can induce protection upon later encounter with the same pathogen (active immunization) or (ii) by transfer of immune effectors between individuals (passive immunization).\r\nIn the second chapter, I built up on a study that I co-authored that found that low-level infections can not only be protective, but also be costly and make the host more susceptible to detrimental superinfections after contact to a very dissimilar pathogen. I here now tested different degrees of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in L. neglectus and can describe the occurrence of cross-protection of social immunization if the first and second pathogen are from the same level. Interestingly, low-level infections only provided protection when the first strain was less virulent than the second strain and elicited higher immune gene expression.\r\nIn the third and fourth chapters, I expanded on the role of social immunity in sexual selection, a so far unstudied field. I used the fungus Metarhizium robertsii and the ant Cardiocondyla obscurior as a model, as in this species mating occurs in the presence of workers and can be studied under laboratory conditions. Before males mate with virgin queens in the nest they engage in fierce combat over the access to their mating partners.\r\nFirst, I focused on male-male competition in the third chapter and found that fighting with a contagious male is costly as it can lead to contamination of the rival, but that workers can decrease the risk of disease contraction by performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal infection on survival and mating success of sexuals (freshly emerged queens and males) and found that worker-performed sanitary care can buffer the negative effect that a pathogenic contagion would have on sexuals by spore removal from the exposed individuals. When social immunity was prevented and queens could contract spores from their mating partner, very low dosages led to negative consequences: their lifespan was reduced and they produced fewer offspring with poor immunocompetence compared to healthy queens. Interestingly, cohabitation with a late-stage infected male where no spore transfer was possible had a positive effect on offspring immunity – male offspring of mothers that apparently perceived an infected partner in their vicinity reacted more sensitively to fungal challenge than male offspring without paternal pathogen history."}],"department":[{"_id":"GradSch"},{"_id":"SyCr"}],"supervisor":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer"}],"corr_author":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1},{"_id":"10759","type":"dissertation","has_accepted_license":"1","language":[{"iso":"eng"}],"file_date_updated":"2022-02-22T07:20:12Z","title":"Analytic and machine learning approaches to composite quantum impurities","article_processing_charge":"No","date_published":"2022-02-21T00:00:00Z","supervisor":[{"last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","orcid":"0000-0002-6990-7802"}],"department":[{"_id":"GradSch"},{"_id":"MiLe"}],"oa":1,"corr_author":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"issn":["2663-337X"]},"date_updated":"2026-06-18T19:29:09Z","year":"2022","date_created":"2022-02-16T13:27:37Z","abstract":[{"text":"In this Thesis, I study composite quantum impurities with variational techniques, both inspired by machine learning as well as fully analytic. I supplement this with exploration of other applications of machine learning, in particular artificial neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle systems with variational approach. I derive a Hamiltonian describing the angulon quasiparticle in the presence of a magnetic field. I apply analytic variational treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive systems, based on artificial neural networks. I exemplify this approach on the example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue using artificial neural networks, albeit in a different setting. I apply artificial neural networks to detect phases from snapshots of two types physical systems. Namely, I study Monte Carlo snapshots of multilayer classical spin models as well as molecular dynamics maps of colloidal systems. The main type of networks that I use here are convolutional neural networks, known for their applicability to image data.","lang":"eng"}],"month":"02","oa_version":"Published Version","status":"public","degree_awarded":"PhD","ddc":["530"],"OA_place":"publisher","doi":"10.15479/at:ista:10759","author":[{"id":"48C55298-F248-11E8-B48F-1D18A9856A87","first_name":"Wojciech","orcid":"0000-0002-1106-4419","last_name":"Rzadkowski","full_name":"Rzadkowski, Wojciech"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"10762"},{"status":"public","relation":"part_of_dissertation","id":"415"},{"id":"8644","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"7956"}]},"day":"21","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program"}],"publisher":"Institute of Science and Technology Austria","citation":{"apa":"Rzadkowski, W. (2022). <i>Analytic and machine learning approaches to composite quantum impurities</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>","short":"W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum Impurities, Institute of Science and Technology Austria, 2022.","mla":"Rzadkowski, Wojciech. <i>Analytic and Machine Learning Approaches to Composite Quantum Impurities</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>.","ama":"Rzadkowski W. Analytic and machine learning approaches to composite quantum impurities. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>","ista":"Rzadkowski W. 2022. Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria.","chicago":"Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite Quantum Impurities.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>.","ieee":"W. Rzadkowski, “Analytic and machine learning approaches to composite quantum impurities,” Institute of Science and Technology Austria, 2022."},"file":[{"checksum":"0fc54ad1eaede879c665ac9b53c93e22","creator":"wrzadkow","date_created":"2022-02-21T13:58:16Z","date_updated":"2022-02-22T07:20:12Z","file_id":"10785","content_type":"application/zip","file_size":17668233,"relation":"source_file","access_level":"closed","file_name":"Rzadkowski_thesis_final_source.zip"},{"file_name":"Rzadkowski_thesis_final.pdf","relation":"main_file","access_level":"open_access","file_size":13307331,"content_type":"application/pdf","date_created":"2022-02-21T14:02:54Z","date_updated":"2022-02-21T14:02:54Z","file_id":"10786","creator":"wrzadkow","checksum":"22d2d7af37ca31f6b1730c26cac7bced","success":1}],"page":"120","publication_status":"published","alternative_title":["ISTA Thesis"],"ec_funded":1},{"department":[{"_id":"GradSch"},{"_id":"NiBa"}],"oa":1,"corr_author":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) [FWF P-32896B].","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"date_updated":"2026-04-07T12:54:28Z","year":"2022","date_created":"2022-02-21T16:08:10Z","publication":"Philosophical Transactions of the Royal Society B: Biological Sciences","abstract":[{"lang":"eng","text":"A species distributed across diverse environments may adapt to local conditions. We ask how quickly such a species changes its range in response to changed conditions. Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210)) used the infinite island model to find the stationary distribution of allele frequencies and deme sizes. We extend this to find how a metapopulation responds to changes in carrying capacity, selection strength, or migration rate when deme sizes are fixed. We further develop a ‘fixed-state’ approximation. Under this approximation, polymorphism is only possible for a narrow range of habitat proportions when selection is weak compared to drift, but for a much wider range otherwise. When rates of selection or migration relative to drift change in a single deme of the metapopulation, the population takes a time of order m−1 to reach the new equilibrium. However, even with many loci, there can be substantial fluctuations in net adaptation, because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation, variation may gradually be lost by chance, even if it would persist in an infinite metapopulation. When conditions change across the whole metapopulation, there can be rapid change, which is predicted well by the fixed-state approximation. This work helps towards an understanding of how metapopulations extend their range across diverse environments.\r\nThis article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’."}],"external_id":{"isi":["000758140300001"],"pmid":["35184588"]},"intvolume":"       377","_id":"10787","type":"journal_article","has_accepted_license":"1","file_date_updated":"2022-08-02T06:14:32Z","language":[{"iso":"eng"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","title":"The response of a metapopulation to a changing environment","date_published":"2022-04-11T00:00:00Z","pmid":1,"author":[{"full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Olusanya, Oluwafunmilola O","last_name":"Olusanya","orcid":"0000-0003-1971-8314","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","first_name":"Oluwafunmilola O"}],"related_material":{"record":[{"id":"14711","status":"public","relation":"dissertation_contains"}]},"day":"11","publisher":"The Royal Society","project":[{"name":"Causes and consequences of population fragmentation","grant_number":"P32896","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"volume":377,"citation":{"ieee":"N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing environment,” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848. The Royal Society, 2022.","apa":"Barton, N. H., &#38; Olusanya, O. O. (2022). The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>","short":"N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society B: Biological Sciences 377 (2022).","chicago":"Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>.","mla":"Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>.","ama":"Barton NH, Olusanya OO. The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. 2022;377(1848). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>","ista":"Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 377(1848)."},"file":[{"content_type":"application/pdf","date_updated":"2022-08-02T06:14:32Z","file_id":"11719","date_created":"2022-08-02T06:14:32Z","file_name":"2022_PhilosophicalTransactionsRSB_Barton.pdf","relation":"main_file","access_level":"open_access","file_size":1349672,"checksum":"3b0243738f01bf3c07e0d7e8dc64f71d","success":1,"creator":"dernst"}],"isi":1,"publication_status":"published","scopus_import":"1","article_type":"original","month":"04","oa_version":"Published Version","status":"public","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"ddc":["570"],"issue":"1848","quality_controlled":"1","doi":"10.1098/rstb.2021.0009"},{"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-015-2"]},"date_updated":"2026-04-07T14:19:48Z","year":"2022","date_created":"2022-02-28T13:03:49Z","abstract":[{"lang":"eng","text":"Because of the increasing popularity of machine learning methods, it is becoming important to understand the impact of learned components on automated decision-making systems and to guarantee that their consequences are beneficial to society. In other words, it is necessary to ensure that machine learning is sufficiently trustworthy to be used in real-world applications. This thesis studies two properties of machine learning models that are highly desirable for the\r\nsake of reliability: robustness and fairness. In the first part of the thesis we study the robustness of learning algorithms to training data corruption. Previous work has shown that machine learning models are vulnerable to a range\r\nof training set issues, varying from label noise through systematic biases to worst-case data manipulations. This is an especially relevant problem from a present perspective, since modern machine learning methods are particularly data hungry and therefore practitioners often have to rely on data collected from various external sources, e.g. from the Internet, from app users or via crowdsourcing. Naturally, such sources vary greatly in the quality and reliability of the\r\ndata they provide. With these considerations in mind, we study the problem of designing machine learning algorithms that are robust to corruptions in data coming from multiple sources. We show that, in contrast to the case of a single dataset with outliers, successful learning within this model is possible both theoretically and practically, even under worst-case data corruptions. The second part of this thesis deals with fairness-aware machine learning. There are multiple areas where machine learning models have shown promising results, but where careful considerations are required, in order to avoid discrimanative decisions taken by such learned components. Ensuring fairness can be particularly challenging, because real-world training datasets are expected to contain various forms of historical bias that may affect the learning process. In this thesis we show that data corruption can indeed render the problem of achieving fairness impossible, by tightly characterizing the theoretical limits of fair learning under worst-case data manipulations. However, assuming access to clean data, we also show how fairness-aware learning can be made practical in contexts beyond binary classification, in particular in the challenging learning to rank setting."}],"supervisor":[{"first_name":"Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph","last_name":"Lampert"}],"department":[{"_id":"GradSch"},{"_id":"ChLa"}],"oa":1,"corr_author":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file_date_updated":"2022-03-10T12:11:48Z","language":[{"iso":"eng"}],"article_processing_charge":"No","title":"Robustness and fairness in machine learning","date_published":"2022-03-08T00:00:00Z","type":"dissertation","_id":"10799","has_accepted_license":"1","citation":{"ieee":"N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute of Science and Technology Austria, 2022.","short":"N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute of Science and Technology Austria, 2022.","apa":"Konstantinov, N. H. (2022). <i>Robustness and fairness in machine learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>","ista":"Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute of Science and Technology Austria.","chicago":"Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>.","ama":"Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>","mla":"Konstantinov, Nikola H. <i>Robustness and Fairness in Machine Learning</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>."},"file":[{"creator":"nkonstan","checksum":"626bc523ae8822d20e635d0e2d95182e","success":1,"file_name":"thesis.pdf","access_level":"open_access","relation":"main_file","file_size":4204905,"content_type":"application/pdf","date_updated":"2022-03-06T11:42:54Z","file_id":"10823","date_created":"2022-03-06T11:42:54Z"},{"file_size":22841103,"relation":"source_file","access_level":"closed","file_name":"thesis.zip","date_created":"2022-03-06T11:42:57Z","date_updated":"2022-03-10T12:11:48Z","file_id":"10824","content_type":"application/x-zip-compressed","creator":"nkonstan","checksum":"e2ca2b88350ac8ea1515b948885cbcb1"}],"publication_status":"published","alternative_title":["ISTA Thesis"],"page":"176","ec_funded":1,"author":[{"last_name":"Konstantinov","full_name":"Konstantinov, Nikola H","orcid":"0009-0009-5204-7621","id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87","first_name":"Nikola H"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"10802"},{"id":"10803","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"6590"},{"relation":"part_of_dissertation","status":"public","id":"8724"}]},"day":"08","project":[{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"665385"}],"publisher":"Institute of Science and Technology Austria","OA_place":"publisher","doi":"10.15479/at:ista:10799","month":"03","oa_version":"Published Version","status":"public","keyword":["robustness","fairness","machine learning","PAC learning","adversarial learning"],"degree_awarded":"PhD","ddc":["000"]},{"type":"journal_article","_id":"9311","intvolume":"        47","date_published":"2022-02-01T00:00:00Z","article_processing_charge":"No","title":"Finite-memory strategies in POMDPs with long-run average objectives","language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"external_id":{"isi":["000731918100001"],"arxiv":["1904.13360"]},"abstract":[{"text":"Partially observable Markov decision processes (POMDPs) are standard models for dynamic systems with probabilistic and nondeterministic behaviour in uncertain environments. We prove that in POMDPs with long-run average objective, the decision maker has approximately optimal strategies with finite memory. This implies notably that approximating the long-run value is recursively enumerable, as well as a weak continuity property of the value with respect to the transition function. ","lang":"eng"}],"date_created":"2021-04-08T09:33:31Z","publication":"Mathematics of Operations Research","year":"2022","date_updated":"2026-04-07T12:31:21Z","arxiv":1,"publication_identifier":{"eissn":["1526-5471"],"issn":["0364-765X"]},"acknowledgement":"Partially supported by Austrian Science Fund (FWF) NFN Grant No RiSE/SHiNE S11407, by CONICYT Chile through grant PII 20150140, and by ECOS-CONICYT through grant C15E03.\r\n","issue":"1","keyword":["Management Science and Operations Research","General Mathematics","Computer Science Applications"],"main_file_link":[{"url":"https://arxiv.org/abs/1904.13360","open_access":"1"}],"status":"public","oa_version":"Preprint","month":"02","article_type":"original","doi":"10.1287/moor.2020.1116","quality_controlled":"1","volume":47,"publisher":"Institute for Operations Research and the Management Sciences","project":[{"_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","call_identifier":"FWF","name":"Game Theory"}],"day":"01","related_material":{"record":[{"id":"20234","relation":"dissertation_contains","status":"public"}]},"author":[{"last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu"},{"full_name":"Saona Urmeneta, Raimundo J","last_name":"Saona Urmeneta","first_name":"Raimundo J","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","orcid":"0000-0001-5103-038X"},{"full_name":"Ziliotto, Bruno","last_name":"Ziliotto","first_name":"Bruno"}],"scopus_import":"1","publication_status":"published","page":"100-119","citation":{"short":"K. Chatterjee, R.J. Saona Urmeneta, B. Ziliotto, Mathematics of Operations Research 47 (2022) 100–119.","apa":"Chatterjee, K., Saona Urmeneta, R. J., &#38; Ziliotto, B. (2022). Finite-memory strategies in POMDPs with long-run average objectives. <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences. <a href=\"https://doi.org/10.1287/moor.2020.1116\">https://doi.org/10.1287/moor.2020.1116</a>","chicago":"Chatterjee, Krishnendu, Raimundo J Saona Urmeneta, and Bruno Ziliotto. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences, 2022. <a href=\"https://doi.org/10.1287/moor.2020.1116\">https://doi.org/10.1287/moor.2020.1116</a>.","ama":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. Finite-memory strategies in POMDPs with long-run average objectives. <i>Mathematics of Operations Research</i>. 2022;47(1):100-119. doi:<a href=\"https://doi.org/10.1287/moor.2020.1116\">10.1287/moor.2020.1116</a>","mla":"Chatterjee, Krishnendu, et al. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” <i>Mathematics of Operations Research</i>, vol. 47, no. 1, Institute for Operations Research and the Management Sciences, 2022, pp. 100–19, doi:<a href=\"https://doi.org/10.1287/moor.2020.1116\">10.1287/moor.2020.1116</a>.","ista":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. 2022. Finite-memory strategies in POMDPs with long-run average objectives. Mathematics of Operations Research. 47(1), 100–119.","ieee":"K. Chatterjee, R. J. Saona Urmeneta, and B. Ziliotto, “Finite-memory strategies in POMDPs with long-run average objectives,” <i>Mathematics of Operations Research</i>, vol. 47, no. 1. Institute for Operations Research and the Management Sciences, pp. 100–119, 2022."},"isi":1},{"article_processing_charge":"No","title":"AC/DC: Alternating Compressed/DeCompressed training of deep neural networks","date_published":"2021-12-06T00:00:00Z","language":[{"iso":"eng"}],"type":"conference","_id":"11458","acknowledged_ssus":[{"_id":"ScienComp"}],"intvolume":"        34","abstract":[{"lang":"eng","text":"The increasing computational requirements of deep neural networks (DNNs) have led to significant interest in obtaining DNN models that are sparse, yet accurate. Recent work has investigated the even harder case of sparse training, where the DNN weights are, for as much as possible, already sparse to reduce computational costs during training. Existing sparse training methods are often empirical and can have lower accuracy relative to the dense baseline. In this paper, we present a general approach called Alternating Compressed/DeCompressed (AC/DC) training of DNNs, demonstrate convergence for a variant of the algorithm, and show that AC/DC outperforms existing sparse training methods in accuracy at similar computational budgets; at high sparsity levels, AC/DC even outperforms existing methods that rely on accurate pre-trained dense models. An important property of AC/DC is that it allows co-training of dense and sparse models, yielding accurate sparse–dense model pairs at the end of the training process. This is useful in practice, where compressed variants may be desirable for deployment in resource-constrained settings without re-doing the entire training flow, and also provides us with insights into the accuracy gap between dense and compressed models. The code is available at: https://github.com/IST-DASLab/ACDC."}],"external_id":{"arxiv":["2106.12379"]},"arxiv":1,"publication_identifier":{"issn":["1049-5258"],"isbn":["9781713845393"]},"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 805223 ScaleML), and a CNRS PEPS grant. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by Scientific Computing (SciComp). We would also like to thank Christoph Lampert for his feedback on an earlier version of this work, as well as for providing hardware for the Transformer-XL experiments.","date_created":"2022-06-20T12:11:53Z","publication":"35th Conference on Neural Information Processing Systems","year":"2021","date_updated":"2026-06-18T17:18:20Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","oa":1,"department":[{"_id":"GradSch"},{"_id":"DaAl"}],"quality_controlled":"1","status":"public","main_file_link":[{"url":"https://proceedings.neurips.cc/paper/2021/file/48000647b315f6f00f913caa757a70b3-Paper.pdf","open_access":"1"}],"ddc":["000"],"month":"12","oa_version":"Published Version","conference":{"start_date":"2021-12-06","name":"NeurIPS: Neural Information Processing Systems","end_date":"2021-12-14","location":"Virtual, Online"},"ec_funded":1,"scopus_import":"1","citation":{"short":"A. Krumes, E.B. Iofinova, A. Vladu, D.-A. Alistarh, in:, 35th Conference on Neural Information Processing Systems, Neural Information Processing Systems Foundation, 2021, pp. 8557–8570.","apa":"Krumes, A., Iofinova, E. B., Vladu, A., &#38; Alistarh, D.-A. (2021). AC/DC: Alternating Compressed/DeCompressed training of deep neural networks. In <i>35th Conference on Neural Information Processing Systems</i> (Vol. 34, pp. 8557–8570). Virtual, Online: Neural Information Processing Systems Foundation.","ista":"Krumes A, Iofinova EB, Vladu A, Alistarh D-A. 2021. AC/DC: Alternating Compressed/DeCompressed training of deep neural networks. 35th Conference on Neural Information Processing Systems. NeurIPS: Neural Information Processing Systems, Advances in Neural Information Processing Systems, vol. 34, 8557–8570.","chicago":"Krumes, Alexandra, Eugenia B Iofinova, Adrian Vladu, and Dan-Adrian Alistarh. “AC/DC: Alternating Compressed/DeCompressed Training of Deep Neural Networks.” In <i>35th Conference on Neural Information Processing Systems</i>, 34:8557–70. Neural Information Processing Systems Foundation, 2021.","mla":"Krumes, Alexandra, et al. “AC/DC: Alternating Compressed/DeCompressed Training of Deep Neural Networks.” <i>35th Conference on Neural Information Processing Systems</i>, vol. 34, Neural Information Processing Systems Foundation, 2021, pp. 8557–70.","ama":"Krumes A, Iofinova EB, Vladu A, Alistarh D-A. AC/DC: Alternating Compressed/DeCompressed training of deep neural networks. In: <i>35th Conference on Neural Information Processing Systems</i>. Vol 34. Neural Information Processing Systems Foundation; 2021:8557-8570.","ieee":"A. Krumes, E. B. Iofinova, A. Vladu, and D.-A. Alistarh, “AC/DC: Alternating Compressed/DeCompressed training of deep neural networks,” in <i>35th Conference on Neural Information Processing Systems</i>, Virtual, Online, 2021, vol. 34, pp. 8557–8570."},"alternative_title":["Advances in Neural Information Processing Systems"],"page":"8557-8570","publication_status":"published","project":[{"_id":"268A44D6-B435-11E9-9278-68D0E5697425","grant_number":"805223","call_identifier":"H2020","name":"Elastic Coordination for Scalable Machine Learning"}],"publisher":"Neural Information Processing Systems Foundation","volume":34,"author":[{"last_name":"Peste","full_name":"Peste, Elena-Alexandra","id":"32D78294-F248-11E8-B48F-1D18A9856A87","first_name":"Elena-Alexandra"},{"last_name":"Iofinova","full_name":"Iofinova, Eugenia B","orcid":"0000-0002-7778-3221","first_name":"Eugenia B","id":"f9a17499-f6e0-11ea-865d-fdf9a3f77117"},{"full_name":"Vladu, Adrian","last_name":"Vladu","first_name":"Adrian"},{"last_name":"Alistarh","full_name":"Alistarh, Dan-Adrian","orcid":"0000-0003-3650-940X","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","first_name":"Dan-Adrian"}],"day":"06","related_material":{"record":[{"id":"13074","status":"public","relation":"dissertation_contains"}]}},{"ec_funded":1,"file":[{"checksum":"c8475faaf0b680b4971f638f1db16347","creator":"shensel","date_updated":"2021-09-15T14:37:30Z","file_id":"10008","date_created":"2021-09-13T11:03:24Z","content_type":"application/x-zip-compressed","relation":"source_file","file_size":15022154,"access_level":"closed","file_name":"thesis_final_Hensel.zip"},{"creator":"shensel","checksum":"1a609937aa5275452822f45f2da17f07","file_size":6583638,"relation":"main_file","access_level":"open_access","file_name":"thesis_final_Hensel.pdf","file_id":"10014","date_updated":"2021-09-14T09:52:47Z","date_created":"2021-09-13T14:18:56Z","content_type":"application/pdf"}],"citation":{"ieee":"S. Hensel, “Curvature driven interface evolution: Uniqueness properties of weak solution concepts,” Institute of Science and Technology Austria, 2021.","ista":"Hensel S. 2021. Curvature driven interface evolution: Uniqueness properties of weak solution concepts. Institute of Science and Technology Austria.","chicago":"Hensel, Sebastian. “Curvature Driven Interface Evolution: Uniqueness Properties of Weak Solution Concepts.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:10007\">https://doi.org/10.15479/at:ista:10007</a>.","mla":"Hensel, Sebastian. <i>Curvature Driven Interface Evolution: Uniqueness Properties of Weak Solution Concepts</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:10007\">10.15479/at:ista:10007</a>.","ama":"Hensel S. Curvature driven interface evolution: Uniqueness properties of weak solution concepts. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:10007\">10.15479/at:ista:10007</a>","apa":"Hensel, S. (2021). <i>Curvature driven interface evolution: Uniqueness properties of weak solution concepts</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10007\">https://doi.org/10.15479/at:ista:10007</a>","short":"S. Hensel, Curvature Driven Interface Evolution: Uniqueness Properties of Weak Solution Concepts, Institute of Science and Technology Austria, 2021."},"publication_status":"published","page":"300","alternative_title":["ISTA Thesis"],"publisher":"Institute of Science and Technology Austria","project":[{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","call_identifier":"H2020"},{"name":"Bridging Scales in Random Materials","_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","call_identifier":"H2020","grant_number":"948819"}],"author":[{"full_name":"Hensel, Sebastian","last_name":"Hensel","orcid":"0000-0001-7252-8072","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian"}],"related_material":{"record":[{"id":"10012","relation":"part_of_dissertation","status":"public"},{"id":"10013","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"7489"}]},"day":"14","doi":"10.15479/at:ista:10007","OA_place":"publisher","status":"public","degree_awarded":"PhD","ddc":["515"],"month":"09","oa_version":"Published Version","abstract":[{"lang":"eng","text":"The present thesis is concerned with the derivation of weak-strong uniqueness principles for curvature driven interface evolution problems not satisfying a comparison principle. The specific examples being treated are two-phase Navier-Stokes flow with surface tension, modeling the evolution of two incompressible, viscous and immiscible fluids separated by a sharp interface, and multiphase mean curvature flow, which serves as an idealized model for the motion of grain boundaries in an annealing polycrystalline material. Our main results - obtained in joint works with Julian Fischer, Tim Laux and Theresa M. Simon - state that prior to the formation of geometric singularities due to topology changes, the weak solution concept of Abels (Interfaces Free Bound. 9, 2007) to two-phase Navier-Stokes flow with surface tension and the weak solution concept of Laux and Otto (Calc. Var. Partial Differential Equations 55, 2016) to multiphase mean curvature flow (for networks in R^2 or double bubbles in R^3) represents the unique solution to these interface evolution problems within the class of classical solutions, respectively. To the best of the author's knowledge, for interface evolution problems not admitting a geometric comparison principle the derivation of a weak-strong uniqueness principle represented an open problem, so that the works contained in the present thesis constitute the first positive results in this direction. The key ingredient of our approach consists of the introduction of a novel concept of relative entropies for a class of curvature driven interface evolution problems, for which the associated energy contains an interfacial contribution being proportional to the surface area of the evolving (network of) interface(s). The interfacial part of the relative entropy gives sufficient control on the interface error between a weak and a classical solution, and its time evolution can be computed, at least in principle, for any energy dissipating weak solution concept. A resulting stability estimate for the relative entropy essentially entails the above mentioned weak-strong uniqueness principles. The present thesis contains a detailed introduction to our relative entropy approach, which in particular highlights potential applications to other problems in curvature driven interface evolution not treated in this thesis."}],"publication_identifier":{"issn":["2663-337X"]},"year":"2021","date_updated":"2026-04-08T07:01:01Z","date_created":"2021-09-13T11:12:34Z","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","supervisor":[{"full_name":"Fischer, Julian L","last_name":"Fischer","first_name":"Julian L","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0479-558X"}],"department":[{"_id":"GradSch"},{"_id":"JuFi"}],"article_processing_charge":"No","title":"Curvature driven interface evolution: Uniqueness properties of weak solution concepts","date_published":"2021-09-14T00:00:00Z","file_date_updated":"2021-09-15T14:37:30Z","language":[{"iso":"eng"}],"_id":"10007","type":"dissertation","has_accepted_license":"1"},{"doi":"10.15479/at:ista:10030","OA_place":"publisher","degree_awarded":"PhD","ddc":["515"],"status":"public","oa_version":"Published Version","month":"09","publication_status":"published","alternative_title":["ISTA Thesis"],"file":[{"relation":"source_file","file_size":3876668,"access_level":"closed","file_name":"tex_and_pictures.zip","date_created":"2021-09-21T09:17:34Z","date_updated":"2022-03-10T12:14:42Z","file_id":"10032","content_type":"application/x-zip-compressed","creator":"cchlebak","checksum":"8cd60dcb8762e8f21867e21e8001e183"},{"creator":"cchlebak","checksum":"9789e9d967c853c1503ec7f307170279","file_size":2532673,"relation":"main_file","access_level":"open_access","file_name":"thesis_portinale_Final (1).pdf","date_created":"2021-09-27T11:14:31Z","file_id":"10047","date_updated":"2021-09-27T11:14:31Z","content_type":"application/pdf"}],"citation":{"apa":"Portinale, L. (2021). <i>Discrete-to-continuum limits of transport problems and gradient flows in the space of measures</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10030\">https://doi.org/10.15479/at:ista:10030</a>","short":"L. Portinale, Discrete-to-Continuum Limits of Transport Problems and Gradient Flows in the Space of Measures, Institute of Science and Technology Austria, 2021.","mla":"Portinale, Lorenzo. <i>Discrete-to-Continuum Limits of Transport Problems and Gradient Flows in the Space of Measures</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:10030\">10.15479/at:ista:10030</a>.","ama":"Portinale L. Discrete-to-continuum limits of transport problems and gradient flows in the space of measures. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:10030\">10.15479/at:ista:10030</a>","ista":"Portinale L. 2021. Discrete-to-continuum limits of transport problems and gradient flows in the space of measures. Institute of Science and Technology Austria.","chicago":"Portinale, Lorenzo. “Discrete-to-Continuum Limits of Transport Problems and Gradient Flows in the Space of Measures.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:10030\">https://doi.org/10.15479/at:ista:10030</a>.","ieee":"L. Portinale, “Discrete-to-continuum limits of transport problems and gradient flows in the space of measures,” Institute of Science and Technology Austria, 2021."},"project":[{"_id":"260788DE-B435-11E9-9278-68D0E5697425","grant_number":"W1245","call_identifier":"FWF","name":"Dissipation and dispersion in nonlinear partial differential equations"},{"grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems"}],"publisher":"Institute of Science and Technology Austria","day":"22","related_material":{"record":[{"id":"9792","relation":"part_of_dissertation","status":"public"},{"id":"10022","relation":"part_of_dissertation","status":"public"},{"id":"7573","status":"public","relation":"part_of_dissertation"}]},"author":[{"first_name":"Lorenzo","id":"30AD2CBC-F248-11E8-B48F-1D18A9856A87","full_name":"Portinale, Lorenzo","last_name":"Portinale"}],"date_published":"2021-09-22T00:00:00Z","title":"Discrete-to-continuum limits of transport problems and gradient flows in the space of measures","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file_date_updated":"2022-03-10T12:14:42Z","language":[{"iso":"eng"}],"has_accepted_license":"1","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"_id":"10030","type":"dissertation","abstract":[{"text":"This PhD thesis is primarily focused on the study of discrete transport problems, introduced for the first time in the seminal works of Maas [Maa11] and Mielke [Mie11] on finite state Markov chains and reaction-diffusion equations, respectively. More in detail, my research focuses on the study of transport costs on graphs, in particular the convergence and the stability of such problems in the discrete-to-continuum limit. This thesis also includes some results concerning\r\nnon-commutative optimal transport. The first chapter of this thesis consists of a general introduction to the optimal transport problems, both in the discrete, the continuous, and the non-commutative setting. Chapters 2 and 3 present the content of two works, obtained in collaboration with Peter Gladbach, Eva Kopfer, and Jan Maas, where we have been able to show the convergence of discrete transport costs on periodic graphs to suitable continuous ones, which can be described by means of a homogenisation result. We first focus on the particular case of quadratic costs on the real line and then extending the result to more general costs in arbitrary dimension. Our results are the first complete characterisation of limits of transport costs on periodic graphs in arbitrary dimension which do not rely on any additional symmetry. In Chapter 4 we turn our attention to one of the intriguing connection between evolution equations and optimal transport, represented by the theory of gradient flows. We show that discrete gradient flow structures associated to a finite volume approximation of a certain class of diffusive equations (Fokker–Planck) is stable in the limit of vanishing meshes, reproving the convergence of the scheme via the method of evolutionary Γ-convergence and exploiting a more variational point of view on the problem. This is based on a collaboration with Dominik Forkert and Jan Maas. Chapter 5 represents a change of perspective, moving away from the discrete world and reaching the non-commutative one. As in the discrete case, we discuss how classical tools coming from the commutative optimal transport can be translated into the setting of density matrices. In particular, in this final chapter we present a non-commutative version of the Schrödinger problem (or entropic regularised optimal transport problem) and discuss existence and characterisation of minimisers, a duality result, and present a non-commutative version of the well-known Sinkhorn algorithm to compute the above mentioned optimisers. This is based on a joint work with Dario Feliciangeli and Augusto Gerolin. Finally, Appendix A and B contain some additional material and discussions, with particular attention to Harnack inequalities and the regularity of flows on discrete spaces.","lang":"eng"}],"date_created":"2021-09-21T09:14:15Z","year":"2021","date_updated":"2026-04-08T07:00:04Z","publication_identifier":{"issn":["2663-337X"]},"acknowledgement":"The author gratefully acknowledges support by the Austrian Science Fund (FWF), grants No W1245.","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","oa":1,"department":[{"_id":"GradSch"},{"_id":"JaMa"}],"supervisor":[{"orcid":"0000-0002-0845-1338","first_name":"Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","full_name":"Maas, Jan","last_name":"Maas"}]},{"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","supervisor":[{"full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","orcid":"0000-0002-9139-1654","first_name":"Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"GradSch"},{"_id":"KrPi"}],"abstract":[{"lang":"eng","text":"Many security definitions come in two flavors: a stronger “adaptive” flavor, where the adversary can arbitrarily make various choices during the course of the attack, and a weaker “selective” flavor where the adversary must commit to some or all of their choices a-priori. For example, in the context of identity-based encryption, selective security requires the adversary to decide on the identity of the attacked party at the very beginning of the game whereas adaptive security allows the attacker to first see the master public key and some secret keys before making this choice. Often, it appears to be much easier to achieve selective security than it is to achieve adaptive security. A series of several recent works shows how to cleverly achieve adaptive security in several such scenarios including generalized selective decryption [Pan07][FJP15], constrained PRFs [FKPR14], and Yao’s garbled circuits [JW16]. Although the above works expressed vague intuition that they share a common technique, the connection was never made precise. In this work we present a new framework (published at Crypto ’17 [JKK+17a]) that connects all of these works and allows us to present them in a unified and simplified fashion. Having the framework in place, we show how to achieve adaptive security for proxy re-encryption schemes (published at PKC ’19 [FKKP19]) and provide the first adaptive security proofs for continuous group key agreement protocols (published at S&P ’21 [KPW+21]). Questioning optimality of our framework, we then show that currently used proof techniques cannot lead to significantly better security guarantees for \"graph-building\" games (published at TCC ’21 [KKPW21a]). These games cover generalized selective decryption, as well as the security of prominent constructions for constrained PRFs, continuous group key agreement, and proxy re-encryption. Finally, we revisit the adaptive security of Yao’s garbled circuits and extend the analysis of Jafargholi and Wichs in two directions: While they prove adaptive security only for a modified construction with increased online complexity, we provide the first positive results for the original construction by Yao (published at TCC ’21 [KKP21a]). On the negative side, we prove that the results of Jafargholi and Wichs are essentially optimal by showing that no black-box reduction can provide a significantly better security bound (published at Crypto ’21 [KKPW21c])."}],"acknowledgement":"I want to acknowledge the funding by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (682815 - TOCNeT).\r\n","publication_identifier":{"issn":["2663-337X"]},"year":"2021","date_updated":"2026-04-16T09:52:03Z","date_created":"2021-09-23T07:31:44Z","_id":"10035","type":"dissertation","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"On the adaptive security of graph-based games","article_processing_charge":"No","date_published":"2021-09-23T00:00:00Z","file_date_updated":"2022-03-10T12:15:18Z","language":[{"iso":"eng"}],"project":[{"name":"Teaching Old Crypto New Tricks","grant_number":"682815","call_identifier":"H2020","_id":"258AA5B2-B435-11E9-9278-68D0E5697425"}],"publisher":"Institute of Science and Technology Austria","author":[{"first_name":"Karen","id":"3E83A2F8-F248-11E8-B48F-1D18A9856A87","last_name":"Klein","full_name":"Klein, Karen"}],"related_material":{"record":[{"id":"10044","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"10048"},{"relation":"part_of_dissertation","status":"public","id":"10041"},{"status":"public","relation":"part_of_dissertation","id":"10049"},{"status":"public","relation":"part_of_dissertation","id":"637"},{"id":"6430","status":"public","relation":"part_of_dissertation"}]},"day":"23","ec_funded":1,"citation":{"ieee":"K. Klein, “On the adaptive security of graph-based games,” Institute of Science and Technology Austria, 2021.","short":"K. Klein, On the Adaptive Security of Graph-Based Games, Institute of Science and Technology Austria, 2021.","apa":"Klein, K. (2021). <i>On the adaptive security of graph-based games</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10035\">https://doi.org/10.15479/at:ista:10035</a>","ista":"Klein K. 2021. On the adaptive security of graph-based games. Institute of Science and Technology Austria.","mla":"Klein, Karen. <i>On the Adaptive Security of Graph-Based Games</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:10035\">10.15479/at:ista:10035</a>.","chicago":"Klein, Karen. “On the Adaptive Security of Graph-Based Games.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:10035\">https://doi.org/10.15479/at:ista:10035</a>.","ama":"Klein K. On the adaptive security of graph-based games. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:10035\">10.15479/at:ista:10035</a>"},"file":[{"checksum":"73a44345c683e81f3e765efbf86fdcc5","success":1,"creator":"cchlebak","content_type":"application/pdf","file_id":"10082","date_updated":"2021-10-04T12:22:33Z","date_created":"2021-10-04T12:22:33Z","file_name":"thesis_pdfa.pdf","file_size":2104726,"access_level":"open_access","relation":"main_file"},{"checksum":"7b80df30a0e686c3ef6a56d4e1c59e29","creator":"cchlebak","file_id":"10085","date_updated":"2022-03-10T12:15:18Z","date_created":"2021-10-05T07:04:37Z","content_type":"application/x-zip-compressed","relation":"source_file","file_size":9538359,"access_level":"closed","file_name":"thesis_final (1).zip"}],"publication_status":"published","alternative_title":["ISTA Thesis"],"page":"276","status":"public","degree_awarded":"PhD","ddc":["519"],"month":"09","oa_version":"Published Version","doi":"10.15479/at:ista:10035","OA_place":"publisher"},{"has_accepted_license":"1","_id":"10058","type":"dissertation","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"date_published":"2021-10-05T00:00:00Z","article_processing_charge":"No","title":"Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole gases","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"language":[{"iso":"eng"}],"file_date_updated":"2022-12-20T23:30:07Z","corr_author":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"department":[{"_id":"GradSch"},{"_id":"GeKa"}],"supervisor":[{"orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","last_name":"Katsaros","full_name":"Katsaros, Georgios"}],"abstract":[{"text":"Quantum information and computation has become a vast field paved with opportunities for researchers and investors. As large multinational companies and international funds are heavily investing in quantum technologies it is still a question which platform is best suited for the task of realizing a scalable quantum processor. In this work we investigate hole spins in Ge quantum wells. These hold great promise as they possess several favorable properties: a small effective mass, a strong spin-orbit coupling, long relaxation time and an inherent immunity to hyperfine noise. All these characteristics helped Ge hole spin qubits to evolve from a single qubit to a fully entangled four qubit processor in only 3 years. Here, we investigated a qubit approach leveraging the large out-of-plane g-factors of heavy hole states in Ge quantum dots. We found this qubit to be reproducibly operable at extremely low magnetic field and at large speeds while maintaining coherence. This was possible because large differences of g-factors in adjacent dots can be achieved in the out-of-plane direction. In the in-plane direction the small g-factors, on the other hand, can be altered very effectively by the confinement potentials. Here, we found that this can even lead to a sign change of the g-factors. The resulting g-factor difference alters the dynamics of the system drastically and produces effects typically attributed to a spin-orbit induced spin-flip term.  The investigations carried out in this thesis give further insights into the possibilities of holes in Ge and reveal new physical properties that need to be considered when designing future spin qubit experiments.","lang":"eng"}],"date_created":"2021-09-30T07:53:49Z","year":"2021","date_updated":"2026-04-08T07:12:19Z","publication_identifier":{"issn":["2663-337X"]},"acknowledgement":"The author gratefully acknowledges support by the Austrian Science Fund (FWF), grants No P30207, and the Nomis foundation.","degree_awarded":"PhD","ddc":["621","539"],"keyword":["qubits","quantum computing","holes"],"status":"public","oa_version":"Published Version","month":"10","doi":"10.15479/at:ista:10058","OA_place":"publisher","project":[{"_id":"2641CE5E-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P30207","name":"Hole spin orbit qubits in Ge quantum wells"}],"publisher":"Institute of Science and Technology Austria","day":"05","related_material":{"record":[{"id":"10066","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"10065"},{"id":"8831","status":"public","relation":"part_of_dissertation"},{"id":"8909","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"5816"}]},"author":[{"orcid":"0000-0002-7197-4801","first_name":"Daniel","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","full_name":"Jirovec, Daniel","last_name":"Jirovec"}],"publication_status":"published","page":"151","alternative_title":["ISTA Thesis"],"file":[{"file_id":"10061","date_updated":"2022-12-20T23:30:07Z","date_created":"2021-09-30T14:29:14Z","content_type":"application/x-zip-compressed","relation":"source_file","access_level":"closed","file_size":32397600,"file_name":"PHD_Thesis_Jirovec_Source.zip","checksum":"ad6bcb24083ed7c02baaf1885c9ea3d5","embargo_to":"open_access","creator":"djirovec"},{"content_type":"application/pdf","date_updated":"2022-12-20T23:30:07Z","file_id":"10087","date_created":"2021-10-05T07:56:49Z","file_name":"PHD_Thesis_pdfa2b_1.pdf","file_size":26910829,"access_level":"open_access","relation":"main_file","checksum":"5fbe08d4f66d1153e04c47971538fae8","embargo":"2022-10-06","creator":"djirovec"}],"citation":{"ieee":"D. Jirovec, “Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole gases,” Institute of Science and Technology Austria, 2021.","mla":"Jirovec, Daniel. <i>Singlet-Triplet Qubits and Spin-Orbit Interaction in 2-Dimensional Ge Hole Gases</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:10058\">10.15479/at:ista:10058</a>.","ama":"Jirovec D. Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole gases. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:10058\">10.15479/at:ista:10058</a>","chicago":"Jirovec, Daniel. “Singlet-Triplet Qubits and Spin-Orbit Interaction in 2-Dimensional Ge Hole Gases.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:10058\">https://doi.org/10.15479/at:ista:10058</a>.","ista":"Jirovec D. 2021. Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole gases. Institute of Science and Technology Austria.","short":"D. Jirovec, Singlet-Triplet Qubits and Spin-Orbit Interaction in 2-Dimensional Ge Hole Gases, Institute of Science and Technology Austria, 2021.","apa":"Jirovec, D. (2021). <i>Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole gases</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10058\">https://doi.org/10.15479/at:ista:10058</a>"}},{"doi":"10.1101/2021.09.28.460602","date_published":"2021-09-29T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"article_processing_charge":"No","title":"The structure of hippocampal CA1 interactions optimizes spatial coding across experience","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","language":[{"iso":"eng"}],"status":"public","_id":"10077","type":"preprint","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2021.09.28.460602","open_access":"1"}],"oa_version":"Preprint","month":"09","abstract":[{"lang":"eng","text":"Although much is known about how single neurons in the hippocampus represent an animal’s position, how cell-cell interactions contribute to spatial coding remains poorly understood. Using a novel statistical estimator and theoretical modeling, both developed in the framework of maximum entropy models, we reveal highly structured cell-to-cell interactions whose statistics depend on familiar vs. novel environment. In both conditions the circuit interactions optimize the encoding of spatial information, but for regimes that differ in the signal-to-noise ratio of their spatial inputs. Moreover, the topology of the interactions facilitates linear decodability, making the information easy to read out by downstream circuits. These findings suggest that the efficient coding hypothesis is not applicable only to individual neuron properties in the sensory periphery, but also to neural interactions in the central brain."}],"ec_funded":1,"publication_status":"draft","year":"2021","date_updated":"2026-06-23T22:31:01Z","publication":"bioRxiv","date_created":"2021-10-04T06:23:34Z","acknowledgement":"We thank Peter Baracskay, Karola Kaefer and Hugo Malagon-Vina for the acquisition of the data. We thank Federico Stella for comments on an earlier version of the manuscript. MN was supported by European Union Horizon 2020 grant 665385, JC was supported by European Research Council consolidator grant 281511, GT was supported by the Austrian Science Fund (FWF) grant P34015, CS was supported by an IST fellow grant, National Institute of Mental Health Award 1R01MH125571-01, by the National Science Foundation under NSF Award No. 1922658 and a Google faculty award.","citation":{"short":"M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, BioRxiv (n.d.).","apa":"Nardin, M., Csicsvari, J. L., Tkačik, G., &#38; Savin, C. (n.d.). The structure of hippocampal CA1 interactions optimizes spatial coding across experience. <i>bioRxiv</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/2021.09.28.460602\">https://doi.org/10.1101/2021.09.28.460602</a>","mla":"Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, doi:<a href=\"https://doi.org/10.1101/2021.09.28.460602\">10.1101/2021.09.28.460602</a>.","ama":"Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2021.09.28.460602\">10.1101/2021.09.28.460602</a>","ista":"Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv, <a href=\"https://doi.org/10.1101/2021.09.28.460602\">10.1101/2021.09.28.460602</a>.","chicago":"Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, n.d. <a href=\"https://doi.org/10.1101/2021.09.28.460602\">https://doi.org/10.1101/2021.09.28.460602</a>.","ieee":"M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal CA1 interactions optimizes spatial coding across experience,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory."},"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program"},{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","call_identifier":"FP7"},{"_id":"626c45b5-2b32-11ec-9570-e509828c1ba6","grant_number":"P34015","name":"Efficient coding with biophysical realism"}],"publisher":"Cold Spring Harbor Laboratory","related_material":{"record":[{"id":"11932","status":"public","relation":"dissertation_contains"},{"id":"14656","status":"public","relation":"later_version"}]},"department":[{"_id":"GradSch"},{"_id":"JoCs"},{"_id":"GaTk"}],"day":"29","author":[{"id":"30BD0376-F248-11E8-B48F-1D18A9856A87","first_name":"Michele","orcid":"0000-0001-8849-6570","full_name":"Nardin, Michele","last_name":"Nardin"},{"first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"},{"full_name":"Tkačik, Gašper","last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gašper","orcid":"0000-0002-6699-1455"},{"full_name":"Savin, Cristina","last_name":"Savin","first_name":"Cristina","id":"3933349E-F248-11E8-B48F-1D18A9856A87"}]},{"citation":{"chicago":"Nardin, Michele, Karola Käfer, and Jozsef L Csicsvari. “The Generalized Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, n.d. <a href=\"https://doi.org/10.1101/2021.09.30.462269\">https://doi.org/10.1101/2021.09.30.462269</a>.","mla":"Nardin, Michele, et al. “The Generalized Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, doi:<a href=\"https://doi.org/10.1101/2021.09.30.462269\">10.1101/2021.09.30.462269</a>.","ista":"Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv, <a href=\"https://doi.org/10.1101/2021.09.30.462269\">10.1101/2021.09.30.462269</a>.","ama":"Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2021.09.30.462269\">10.1101/2021.09.30.462269</a>","short":"M. Nardin, K. Käfer, J.L. Csicsvari, BioRxiv (n.d.).","apa":"Nardin, M., Käfer, K., &#38; Csicsvari, J. L. (n.d.). The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. <i>bioRxiv</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/2021.09.30.462269\">https://doi.org/10.1101/2021.09.30.462269</a>","ieee":"M. Nardin, K. Käfer, and J. L. Csicsvari, “The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory."},"acknowledgement":"We thank Federico Stella for invaluable suggestions and discussions. We thank Yosman BapatDhar and Andrea Cumpelik for comments, help and suggestions on the exposure of the text. We thank Predrag Živadinović and Juliana Couras for comments on the text and the figures. This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616).","date_created":"2021-10-04T06:28:32Z","publication":"bioRxiv","date_updated":"2025-04-15T06:48:21Z","year":"2021","publication_status":"submitted","abstract":[{"lang":"eng","text":"Hippocampal and neocortical neural activity is modulated by the position of the individual in space. While hippocampal neurons provide the basis for a spatial map, prefrontal cortical neurons generalize over environmental features. Whether these generalized representations result from a bidirectional interaction with, or are mainly derived from hippocampal spatial representations is not known. By examining simultaneously recorded hippocampal and medial prefrontal neurons, we observed that prefrontal spatial representations show a delayed coherence with hippocampal ones. We also identified subpopulations of cells in the hippocampus and medial prefrontal cortex that formed functional cross-area couplings; these resembled the optimal connections predicted by a probabilistic model of spatial information transfer and generalization. Moreover, cross-area couplings were strongest and had the shortest delay preceding spatial decision-making. Our results suggest that generalized spatial coding in the medial prefrontal cortex is inherited from spatial representations in the hippocampus, and that the routing of information can change dynamically with behavioral demands."}],"ec_funded":1,"author":[{"id":"30BD0376-F248-11E8-B48F-1D18A9856A87","first_name":"Michele","orcid":"0000-0001-8849-6570","last_name":"Nardin","full_name":"Nardin, Michele"},{"first_name":"Karola","id":"2DAA49AA-F248-11E8-B48F-1D18A9856A87","full_name":"Käfer, Karola","last_name":"Käfer"},{"last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","orcid":"0000-0002-5193-4036"}],"day":"02","department":[{"_id":"GradSch"},{"_id":"JoCs"}],"publisher":"Cold Spring Harbor Laboratory","project":[{"name":"inter-and intracellular signalling in schizophrenia","grant_number":"607616","call_identifier":"FP7","_id":"257BBB4C-B435-11E9-9278-68D0E5697425"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"language":[{"iso":"eng"}],"title":"The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus","article_processing_charge":"No","doi":"10.1101/2021.09.30.462269","date_published":"2021-10-02T00:00:00Z","month":"10","oa_version":"Preprint","type":"preprint","_id":"10080","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2021.09.30.462269"}],"status":"public"},{"project":[{"name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"_id":"26B4D67E-B435-11E9-9278-68D0E5697425","grant_number":"25351","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root"}],"publisher":"Institute of Science and Technology Austria","day":"06","related_material":{"record":[{"id":"442","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"6627"},{"relation":"part_of_dissertation","status":"public","id":"8931"},{"status":"public","relation":"part_of_dissertation","id":"8986"},{"id":"10095","relation":"part_of_dissertation","status":"public"},{"id":"8283","relation":"part_of_dissertation","status":"public"},{"id":"9287","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"10015"}]},"author":[{"full_name":"Li, Lanxin","last_name":"Li","first_name":"Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X"}],"ec_funded":1,"publication_status":"published","alternative_title":["ISTA Thesis"],"file":[{"file_name":"0._IST_Austria_Thesis_Lanxin_Li_1014_pdftron.pdf","relation":"main_file","file_size":8616142,"access_level":"open_access","content_type":"application/pdf","file_id":"10138","date_updated":"2022-12-20T23:30:03Z","date_created":"2021-10-14T08:00:07Z","creator":"cchlebak","checksum":"3b2f55b3b8ae05337a0dcc1cd8595b10","embargo":"2022-10-14"},{"file_name":"0._IST_Austria_Thesis_Lanxin_Li_1014.docx","relation":"source_file","file_size":15058499,"access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"10139","date_updated":"2022-12-20T23:30:03Z","date_created":"2021-10-14T08:00:13Z","creator":"cchlebak","embargo_to":"open_access","checksum":"f23ed258ca894f6aabf58b0c128bf242"}],"citation":{"chicago":"Li, Lanxin. “Rapid Cell Growth Regulation in Arabidopsis.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:10083\">https://doi.org/10.15479/at:ista:10083</a>.","ama":"Li L. Rapid cell growth regulation in Arabidopsis. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:10083\">10.15479/at:ista:10083</a>","mla":"Li, Lanxin. <i>Rapid Cell Growth Regulation in Arabidopsis</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:10083\">10.15479/at:ista:10083</a>.","ista":"Li L. 2021. Rapid cell growth regulation in Arabidopsis. Institute of Science and Technology Austria.","short":"L. Li, Rapid Cell Growth Regulation in Arabidopsis, Institute of Science and Technology Austria, 2021.","apa":"Li, L. (2021). <i>Rapid cell growth regulation in Arabidopsis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10083\">https://doi.org/10.15479/at:ista:10083</a>","ieee":"L. Li, “Rapid cell growth regulation in Arabidopsis,” Institute of Science and Technology Austria, 2021."},"ddc":["575"],"degree_awarded":"PhD","status":"public","oa_version":"Published Version","month":"10","doi":"10.15479/at:ista:10083","OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","oa":1,"department":[{"_id":"GradSch"},{"_id":"JiFr"}],"supervisor":[{"full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"abstract":[{"lang":"eng","text":"Plant motions occur across a wide spectrum of timescales, ranging from seed dispersal through bursting (milliseconds) and stomatal opening (minutes) to long-term adaptation of gross architecture. Relatively fast motions include water-driven growth as exemplified by root cell expansion under abiotic/biotic stresses or during gravitropism. A showcase is a root growth inhibition in 30 seconds triggered by the phytohormone auxin. However, the cellular and molecular mechanisms are still largely unknown. This thesis covers the studies about this topic as follows. By taking advantage of microfluidics combined with live imaging, pharmaceutical tools, and transgenic lines, we examined the kinetics of and causal relationship among various auxininduced rapid cellular changes in root growth, apoplastic pH, cytosolic Ca2+, cortical microtubule (CMT) orientation, and vacuolar morphology. We revealed that CMT reorientation and vacuolar constriction are the consequence of growth itself instead of responding directly to auxin. In contrast, auxin induces apoplast alkalinization to rapidly inhibit root growth in 30 seconds. This auxin-triggered apoplast alkalinization results from rapid H+- influx that is contributed by Ca2+ inward channel CYCLIC NUCLEOTIDE-GATED CHANNEL 14 (CNGC14)-dependent Ca2+ signaling. To dissect which auxin signaling mediates the rapid apoplast alkalinization, we\r\ncombined microfluidics and genetic engineering to verify that TIR1/AFB receptors conduct a non-transcriptional regulation on Ca2+ and H+ -influx. This non-canonical pathway is mostly mediated by the cytosolic portion of TIR1/AFB. On the other hand, we uncovered, using biochemical and phospho-proteomic analysis, that auxin cell surface signaling component TRANSMEMBRANE KINASE 1 (TMK1) plays a negative role during auxin-trigger apoplast\r\nalkalinization and root growth inhibition through directly activating PM H+ -ATPases. Therefore, we discovered that PM H+ -ATPases counteract instead of mediate the auxintriggered rapid H+ -influx, and that TIR1/AFB and TMK1 regulate root growth antagonistically. This opposite effect of TIR1/AFB and TMK1 is consistent during auxin-induced hypocotyl elongation, leading us to explore the relation of two signaling pathways. Assisted with biochemistry and fluorescent imaging, we verified for the first time that TIR1/AFB and TMK1 can interact with each other. The ability of TIR1/AFB binding to membrane lipid provides a basis for the interaction of plasma membrane- and cytosol-localized proteins.\r\nBesides, transgenic analysis combined with genetic engineering and biochemistry showed that  vi\r\nthey do function in the same pathway. Particularly, auxin-induced TMK1 increase is TIR1/AFB dependent, suggesting TIR1/AFB regulation on TMK1. Conversely, TMK1 also regulates TIR1/AFB protein levels and thus auxin canonical signaling. To follow the study of rapid growth regulation, we analyzed another rapid growth regulator, signaling peptide RALF1. We showed that RALF1 also triggers a rapid and reversible growth inhibition caused by H + influx, highly resembling but not dependent on auxin. Besides, RALF1 promotes auxin biosynthesis by increasing expression of auxin biosynthesis enzyme YUCCAs and thus induces auxin signaling in ca. 1 hour, contributing to the sustained RALF1-triggered growth inhibition. These studies collectively contribute to understanding rapid regulation on plant cell\r\ngrowth, novel auxin signaling pathway as well as auxin-peptide crosstalk. "}],"date_created":"2021-10-04T13:33:10Z","date_updated":"2026-04-16T12:20:41Z","year":"2021","publication_identifier":{"issn":["2663-337X"]},"has_accepted_license":"1","type":"dissertation","_id":"10083","date_published":"2021-10-06T00:00:00Z","article_processing_charge":"No","title":"Rapid cell growth regulation in Arabidopsis","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"language":[{"iso":"eng"}],"file_date_updated":"2022-12-20T23:30:03Z"}]