In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour
Project Period: 2016-07-01 – 2022-06-30
Funder:
European Research Council
Acronym
SINCHAIS
Principal Investigator
Department(s)
Grant Number
694539
Grant DOI
Funder
European Research Council
Funder Schema
H2020-ERC-AdG
Funder Registry
15 Publications
2025 | Published | Thesis | IST-REx-ID: 19271
Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula
C. Önal, Asymmetrical Modulation of Fear Expression via GABAB Receptors in the Mouse Medial Habenula, Institute of Science and Technology Austria, 2025.
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C. Önal, Asymmetrical Modulation of Fear Expression via GABAB Receptors in the Mouse Medial Habenula, Institute of Science and Technology Austria, 2025.
2024 | Published | Book Chapter | IST-REx-ID: 18052
Automated Imaging and Analysis of Synapses in Freeze-Fracture Replica Samples with Deep Learning
D. Kleindienst, T. Costanzo, R. Shigemoto, in:, J.H.R. Lübke, A. Rollenhagen (Eds.), New Aspects in Analyzing the Synaptic Organization of the Brain, 1st ed., Springer Nature, New York, 2024, pp. 123–137.
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D. Kleindienst, T. Costanzo, R. Shigemoto, in:, J.H.R. Lübke, A. Rollenhagen (Eds.), New Aspects in Analyzing the Synaptic Organization of the Brain, 1st ed., Springer Nature, New York, 2024, pp. 123–137.
2024 | Published | Journal Article | IST-REx-ID: 15084 | 
GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles
P. Koppensteiner, P. Bhandari, C. Önal, C. Borges Merjane, E. Le Monnier, U. Roy, Y. Nakamura, T. Sadakata, M. Sanbo, M. Hirabayashi, J. Rhee, N. Brose, P.M. Jonas, R. Shigemoto, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
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P. Koppensteiner, P. Bhandari, C. Önal, C. Borges Merjane, E. Le Monnier, U. Roy, Y. Nakamura, T. Sadakata, M. Sanbo, M. Hirabayashi, J. Rhee, N. Brose, P.M. Jonas, R. Shigemoto, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
2023 | Published | Journal Article | IST-REx-ID: 13202 |
Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons
K. Eguchi, E. Le Monnier, R. Shigemoto, The Journal of Neuroscience 43 (2023) 4197–4216.
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K. Eguchi, E. Le Monnier, R. Shigemoto, The Journal of Neuroscience 43 (2023) 4197–4216.
2022 | Published | Journal Article | IST-REx-ID: 10890 |
The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals
K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, R. Shigemoto, Frontiers in Neuroanatomy 16 (2022).
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K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, R. Shigemoto, Frontiers in Neuroanatomy 16 (2022).
2022 | Published | Journal Article | IST-REx-ID: 10889 |
Electron microscopic visualization of single molecules by tag-mediated metal particle labeling
R. Shigemoto, Microscopy 71 (2022) i72–i80.
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R. Shigemoto, Microscopy 71 (2022) i72–i80.
2021 | Published | Journal Article | IST-REx-ID: 7551 |
Ventro-dorsal hippocampal pathway gates novelty-induced contextual memory formation
F.A. Fredes Tolorza, M.A. Silva Sifuentes, P. Koppensteiner, K. Kobayashi, M.A. Jösch, R. Shigemoto, Current Biology 31 (2021) P25–38.E5.
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F.A. Fredes Tolorza, M.A. Silva Sifuentes, P. Koppensteiner, K. Kobayashi, M.A. Jösch, R. Shigemoto, Current Biology 31 (2021) P25–38.E5.
2021 | Published | Journal Article | IST-REx-ID: 9641 |
The role of hippocampal mossy cells in novelty detection
Fredes, Felipe, The role of hippocampal mossy cells in novelty detection. Neurobiology of Learning and Memory 183. 2021
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Fredes, Felipe, The role of hippocampal mossy cells in novelty detection. Neurobiology of Learning and Memory 183. 2021
2021 | Published | Journal Article | IST-REx-ID: 9330 |
Presynaptic α2δ subunits are key organizers of glutamatergic synapses
C.L. Schöpf, C. Ablinger, S.M. Geisler, R.I. Stanika, M. Campiglio, W. Kaufmann, B. Nimmervoll, B. Schlick, J. Brockhaus, M. Missler, R. Shigemoto, G.J. Obermair, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).
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C.L. Schöpf, C. Ablinger, S.M. Geisler, R.I. Stanika, M. Campiglio, W. Kaufmann, B. Nimmervoll, B. Schlick, J. Brockhaus, M. Missler, R. Shigemoto, G.J. Obermair, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9437 |
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
P. Bhandari, D.H. Vandael, D. Fernández-Fernández, T. Fritzius, D. Kleindienst, C. Önal, J.-C. Montanaro-Punzengruber, M. Gassmann, P.M. Jonas, A. Kulik, B. Bettler, R. Shigemoto, P. Koppensteiner, ELife 10 (2021).
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P. Bhandari, D.H. Vandael, D. Fernández-Fernández, T. Fritzius, D. Kleindienst, C. Önal, J.-C. Montanaro-Punzengruber, M. Gassmann, P.M. Jonas, A. Kulik, B. Bettler, R. Shigemoto, P. Koppensteiner, ELife 10 (2021).
2021 | Published | Book Chapter | IST-REx-ID: 9756
High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL)
W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:, Receptor and Ion Channel Detection in the Brain, Humana, New York, 2021, pp. 267–283.
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W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:, Receptor and Ion Channel Detection in the Brain, Humana, New York, 2021, pp. 267–283.
2020 | Published | Journal Article | IST-REx-ID: 7665 |
Advantages of acute brain slices prepared at physiological temperature in the characterization of synaptic functions
Eguchi, Kohgaku, Advantages of acute brain slices prepared at physiological temperature in the characterization of synaptic functions. Frontiers in Cellular Neuroscience 14. 2020
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Eguchi, Kohgaku, Advantages of acute brain slices prepared at physiological temperature in the characterization of synaptic functions. Frontiers in Cellular Neuroscience 14. 2020
2020 | Published | Journal Article | IST-REx-ID: 8532 |
Deep learning-assisted high-throughput analysis of freeze-fracture replica images applied to glutamate receptors and calcium channels at hippocampal synapses
Kleindienst, David, Deep learning-assisted high-throughput analysis of freeze-fracture replica images applied to glutamate receptors and calcium channels at hippocampal synapses. International Journal of Molecular Sciences 21 (18). 2020
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Kleindienst, David, Deep learning-assisted high-throughput analysis of freeze-fracture replica images applied to glutamate receptors and calcium channels at hippocampal synapses. International Journal of Molecular Sciences 21 (18). 2020
2019 | Published | Journal Article | IST-REx-ID: 6659 |
Optimized reaction pair of the CysHis tag and Ni(II)-NTA probe for highly selective chemical labeling of membrane proteins
Zenmyo, Naoki, Optimized reaction pair of the CysHis tag and Ni(II)-NTA probe for highly selective chemical labeling of membrane proteins. Bulletin of the Chemical Society of Japan 92 (5). 2019
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Zenmyo, Naoki, Optimized reaction pair of the CysHis tag and Ni(II)-NTA probe for highly selective chemical labeling of membrane proteins. Bulletin of the Chemical Society of Japan 92 (5). 2019
2019 | Published | Journal Article | IST-REx-ID: 7391 |
Electron microscopic detection of single membrane proteins by a specific chemical labeling
S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto, A. Ojida, IScience 22 (2019) 256–268.
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S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto, A. Ojida, IScience 22 (2019) 256–268.