Can evolution minimize spurious signaling crosstalk to reach optimal performance?
Project Period: 2018-12-01 – 2021-11-30
Funder:
HFSP
Principal Investigator
Department(s)
Grant Number
RGP0034/2018
Funder
HFSP
5 Publications
2024 | Published | Thesis | IST-REx-ID: 15020 | 
Genetic information and biological optimization
M. Hledik, Genetic Information and Biological Optimization, Institute of Science and Technology Austria, 2024.
[Published Version]
View
| Files available
| DOI
M. Hledik, Genetic Information and Biological Optimization, Institute of Science and Technology Austria, 2024.
2024 | Published | Journal Article | IST-REx-ID: 18525 |
Quantitative omnigenic model discovers interpretable genome-wide associations
N. Ruzickova, M. Hledik, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
[Published Version]
View
| Files available
| DOI
N. Ruzickova, M. Hledik, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
2022 | Published | Journal Article | IST-REx-ID: 12081 |
Accumulation and maintenance of information in evolution
M. Hledik, N.H. Barton, G. Tkačik, Proceedings of the National Academy of Sciences 119 (2022).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M. Hledik, N.H. Barton, G. Tkačik, Proceedings of the National Academy of Sciences 119 (2022).
2020 | Published | Journal Article | IST-REx-ID: 9000 |
Nonequilibrium models of optimal enhancer function
R. Grah, B. Zoller, G. Tkačik, PNAS 117 (2020) 31614–31622.
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
R. Grah, B. Zoller, G. Tkačik, PNAS 117 (2020) 31614–31622.
2020 | Published | Preprint | IST-REx-ID: 7675 |
Normative models of enhancer function
R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
[Preprint]
View
| Files available
| DOI
| Download Preprint (ext.)
R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).