Structural conservation and diversity in retroviral capsid

Project Period: 2018-10-01 – 2021-09-30

Funder: FWF

Principal Investigator

Schur, Florian

Department(s)

Schur Group

Grant Number

P31445

Funder

FWF

2024 | Published | Thesis | IST-REx-ID: 18766 |

Elucidating the structural determinants of the poxvirus core using multi-modal cryo-EM
J. Datler, Elucidating the Structural Determinants of the Poxvirus Core Using Multi-Modal Cryo-EM, Institute of Science and Technology Austria, 2024.

[Published Version] View | Files available | DOI

2024 | Published | Journal Article | IST-REx-ID: 14979 |

Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores
J. Datler, J. Hansen, A. Thader, A. Schlögl, L.W. Bauer, V.-V. Hodirnau, F.K. Schur, Nature Structural & Molecular Biology 31 (2024) 1114–1123.

[Published Version] View | Files available | DOI | PubMed | Europe PMC

2024 | Epub ahead of print | Journal Article | IST-REx-ID: 17884 |

Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice
M. Obr, M. Percipalle, D. Chernikova, H. Yang, A. Thader, G. Pinke, D. Porley Esteves, L.M. Mansky, R.A. Dick, F.K. Schur, Nature Structural & Molecular Biology (2024).

[Published Version] View | Files available | DOI | Download Published Version (ext.)

2023 | Published | Journal Article | IST-REx-ID: 14255 |

The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells
J. Koch, Q. Xin, M. Obr, A. Schäfer, N. Rolfs, H.A. Anagho, A. Kudulyte, L. Woltereck, S. Kummer, J. Campos, Z.M. Uckeley, L. Bell-Sakyi, H.G. Kräusslich, F.K. Schur, C. Acuna, P.Y. Lozach, PLoS Pathogens 19 (2023).

2022 | Published | Journal Article | IST-REx-ID: 10639 |

The Orthobunyavirus Germiston enters host cells from late endosomes
S. Windhaber, Q. Xin, Z.M. Uckeley, J. Koch, M. Obr, C. Garnier, C. Luengo-Guyonnot, M. Duboeuf, F.K. Schur, P.-Y. Lozach, Journal of Virology 96 (2022).

2022 | Published | Journal Article | IST-REx-ID: 11155 |

Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs
M. Obr, W.J.H. Hagen, R.A. Dick, L. Yu, A. Kotecha, F.K. Schur, Journal of Structural Biology 214 (2022).

2021 | Published | Journal Article | IST-REx-ID: 10103 |

2021 | Published | Journal Article | IST-REx-ID: 9431 |

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer
M. Obr, C.L. Ricana, N. Nikulin, J.-P.R. Feathers, M. Klanschnig, A. Thader, M.C. Johnson, V.M. Vogt, F.K. Schur, R.A. Dick, Nature Communications 12 (2021).

[Published Version] View | Files available | DOI | WoS

2020 | Published | Journal Article | IST-REx-ID: 7464 |

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly
R.A. Dick, C. Xu, D.R. Morado, V. Kravchuk, C.L. Ricana, T.D. Lyddon, A.M. Broad, J.R. Feathers, M.C. Johnson, V.M. Vogt, J.R. Perilla, J.A.G. Briggs, F.K. Schur, PLOS Pathogens 16 (2020).