Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression Schmitt, Heather M. Fehrman, Rachel L. Maes, Margaret E ; https://orcid.org/0000-0001-9642-1085 Yang, Huan Guo, Lian Wang Schlamp, Cassandra L. Pelzel, Heather R. Nickells, Robert W. ddc:570 Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs) after acute optic nerve damage. Consistent with this, induced HDAC3 expression in cultured cells shows selective toxicity to neurons. Despite an established role for HDAC3 in neuronal pathology, little is known regarding the mechanism of this pathology. Association for Research in Vision and Ophthalmology 2021 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/10000 https://research-explorer.ista.ac.at/download/10000/11369 Schmitt HM, Fehrman RL, Maes ME, et al. Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression. <i>Investigative Ophthalmology and Visual Science</i>. 2021;62(10). doi:<a href="https://doi.org/10.1167/IOVS.62.10.14">10.1167/IOVS.62.10.14</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1167/IOVS.62.10.14 info:eu-repo/semantics/altIdentifier/issn/0146-0404 info:eu-repo/semantics/altIdentifier/e-issn/1552-5783 info:eu-repo/semantics/altIdentifier/wos/000695230000014 info:eu-repo/semantics/altIdentifier/pmid/34398198 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess