article published yes Heather M. Schmitt author Rachel L. Fehrman author Margaret E Maes author 3838F452-F248-11E8-B48F-1D18A9856A870000-0001-9642-1085 Huan Yang author Lian Wang Guo author Cassandra L. Schlamp author Heather R. Pelzel author Robert W. Nickells author SaSi department Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs) after acute optic nerve damage. Consistent with this, induced HDAC3 expression in cultured cells shows selective toxicity to neurons. Despite an established role for HDAC3 in neuronal pathology, little is known regarding the mechanism of this pathology. https://research-explorer.ista.ac.at/download/10000/11369/2021_IOVS_Schmitt.pdf application/pdfno Association for Research in Vision and Ophthalmology2021 eng 0146-0404 1552-5783 34398198 00069523000001410.1167/IOVS.62.10.14 6210 H. M. Schmitt <i>et al.</i>, “Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression,” <i>Investigative Ophthalmology &#38; Visual Science</i>, vol. 62, no. 10. Association for Research in Vision and Ophthalmology, 2021. Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. 2021. Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression. Investigative Ophthalmology &#38; Visual Science. 62(10), 14. Schmitt HM, Fehrman RL, Maes ME, et al. Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression. <i>Investigative Ophthalmology &#38; Visual Science</i>. 2021;62(10). doi:<a href="https://doi.org/10.1167/IOVS.62.10.14">10.1167/IOVS.62.10.14</a> Schmitt, Heather M., Rachel L. Fehrman, Margaret E Maes, Huan Yang, Lian Wang Guo, Cassandra L. Schlamp, Heather R. Pelzel, and Robert W. Nickells. “Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.” <i>Investigative Ophthalmology &#38; Visual Science</i>. Association for Research in Vision and Ophthalmology, 2021. <a href="https://doi.org/10.1167/IOVS.62.10.14">https://doi.org/10.1167/IOVS.62.10.14</a>. Schmitt, H. M., Fehrman, R. L., Maes, M. E., Yang, H., Guo, L. W., Schlamp, C. L., … Nickells, R. W. (2021). Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression. <i>Investigative Ophthalmology &#38; Visual Science</i>. Association for Research in Vision and Ophthalmology. <a href="https://doi.org/10.1167/IOVS.62.10.14">https://doi.org/10.1167/IOVS.62.10.14</a> Schmitt, Heather M., et al. “Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.” <i>Investigative Ophthalmology &#38; Visual Science</i>, vol. 62, no. 10, 14, Association for Research in Vision and Ophthalmology, 2021, doi:<a href="https://doi.org/10.1167/IOVS.62.10.14">10.1167/IOVS.62.10.14</a>. H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R. Pelzel, R.W. Nickells, Investigative Ophthalmology &#38; Visual Science 62 (2021). 100002021-09-12T22:01:23Z2026-08-12T11:15:05Z