---
_id: '10000'
abstract:
- lang: eng
  text: Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective
    in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs)
    after acute optic nerve damage. Consistent with this, induced HDAC3 expression
    in cultured cells shows selective toxicity to neurons. Despite an established
    role for HDAC3 in neuronal pathology, little is known regarding the mechanism
    of this pathology.
acknowledgement: 'The authors thank Joel Dietz for maintaining the mice used in this
  study, Satoshi Kinoshita and the Translational Research Initiative in Pathology
  Laboratory at the University of Wisconsin-Madison for cutting retinal sections analyzed
  in this study, and Mark Banghart for statistical review of the data analysis. Supported
  by National Eye Institute Grants R01 EY012223 (RWN), R01 EY030123 (RWN), R01 EY029809
  (LWG), R01 EY029809 (LWG) and a Vision Research CORE grant P30 EY016665, NRSA grant
  T32 GM081061, by an unrestricted research grant from Research to Prevent Blindness,
  Inc., and by a University of Wisconsin-Madison Vilas Life Cycle award and the Frederick
  A. Davis Research Chair (RWN). '
article_number: '14'
article_processing_charge: Yes
article_type: original
author:
- first_name: Heather M.
  full_name: Schmitt, Heather M.
  last_name: Schmitt
- first_name: Rachel L.
  full_name: Fehrman, Rachel L.
  last_name: Fehrman
- first_name: Margaret E
  full_name: Maes, Margaret E
  id: 3838F452-F248-11E8-B48F-1D18A9856A87
  last_name: Maes
  orcid: 0000-0001-9642-1085
- first_name: Huan
  full_name: Yang, Huan
  last_name: Yang
- first_name: Lian Wang
  full_name: Guo, Lian Wang
  last_name: Guo
- first_name: Cassandra L.
  full_name: Schlamp, Cassandra L.
  last_name: Schlamp
- first_name: Heather R.
  full_name: Pelzel, Heather R.
  last_name: Pelzel
- first_name: Robert W.
  full_name: Nickells, Robert W.
  last_name: Nickells
citation:
  ama: Schmitt HM, Fehrman RL, Maes ME, et al. Increased susceptibility and intrinsic
    apoptotic signaling in neurons by induced HDAC3 expression. <i>Investigative Ophthalmology
    and Visual Science</i>. 2021;62(10). doi:<a href="https://doi.org/10.1167/IOVS.62.10.14">10.1167/IOVS.62.10.14</a>
  apa: Schmitt, H. M., Fehrman, R. L., Maes, M. E., Yang, H., Guo, L. W., Schlamp,
    C. L., … Nickells, R. W. (2021). Increased susceptibility and intrinsic apoptotic
    signaling in neurons by induced HDAC3 expression. <i>Investigative Ophthalmology
    and Visual Science</i>. Association for Research in Vision and Ophthalmology.
    <a href="https://doi.org/10.1167/IOVS.62.10.14">https://doi.org/10.1167/IOVS.62.10.14</a>
  chicago: Schmitt, Heather M., Rachel L. Fehrman, Margaret E Maes, Huan Yang, Lian
    Wang Guo, Cassandra L. Schlamp, Heather R. Pelzel, and Robert W. Nickells. “Increased
    Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.”
    <i>Investigative Ophthalmology and Visual Science</i>. Association for Research
    in Vision and Ophthalmology, 2021. <a href="https://doi.org/10.1167/IOVS.62.10.14">https://doi.org/10.1167/IOVS.62.10.14</a>.
  ieee: H. M. Schmitt <i>et al.</i>, “Increased susceptibility and intrinsic apoptotic
    signaling in neurons by induced HDAC3 expression,” <i>Investigative Ophthalmology
    and Visual Science</i>, vol. 62, no. 10. Association for Research in Vision and
    Ophthalmology, 2021.
  ista: Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells
    RW. 2021. Increased susceptibility and intrinsic apoptotic signaling in neurons
    by induced HDAC3 expression. Investigative Ophthalmology and Visual Science. 62(10),
    14.
  mla: Schmitt, Heather M., et al. “Increased Susceptibility and Intrinsic Apoptotic
    Signaling in Neurons by Induced HDAC3 Expression.” <i>Investigative Ophthalmology
    and Visual Science</i>, vol. 62, no. 10, 14, Association for Research in Vision
    and Ophthalmology, 2021, doi:<a href="https://doi.org/10.1167/IOVS.62.10.14">10.1167/IOVS.62.10.14</a>.
  short: H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R.
    Pelzel, R.W. Nickells, Investigative Ophthalmology and Visual Science 62 (2021).
date_created: 2021-09-12T22:01:23Z
date_published: 2021-08-16T00:00:00Z
date_updated: 2023-08-14T06:35:17Z
day: '16'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.1167/IOVS.62.10.14
external_id:
  isi:
  - '000695230000014'
  pmid:
  - '34398198'
file:
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  checksum: c430967746f653aa1ae84ee617f62b73
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-13T07:40:15Z
  date_updated: 2022-05-13T07:40:15Z
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  file_size: 19707796
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file_date_updated: 2022-05-13T07:40:15Z
has_accepted_license: '1'
intvolume: '        62'
isi: 1
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Investigative Ophthalmology and Visual Science
publication_identifier:
  eissn:
  - 1552-5783
  issn:
  - 0146-0404
publication_status: published
publisher: Association for Research in Vision and Ophthalmology
quality_controlled: '1'
scopus_import: '1'
status: public
title: Increased susceptibility and intrinsic apoptotic signaling in neurons by induced
  HDAC3 expression
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 62
year: '2021'
...