---
_id: '10080'
abstract:
- lang: eng
  text: Hippocampal and neocortical neural activity is modulated by the position of
    the individual in space. While hippocampal neurons provide the basis for a spatial
    map, prefrontal cortical neurons generalize over environmental features. Whether
    these generalized representations result from a bidirectional interaction with,
    or are mainly derived from hippocampal spatial representations is not known. By
    examining simultaneously recorded hippocampal and medial prefrontal neurons, we
    observed that prefrontal spatial representations show a delayed coherence with
    hippocampal ones. We also identified subpopulations of cells in the hippocampus
    and medial prefrontal cortex that formed functional cross-area couplings; these
    resembled the optimal connections predicted by a probabilistic model of spatial
    information transfer and generalization. Moreover, cross-area couplings were strongest
    and had the shortest delay preceding spatial decision-making. Our results suggest
    that generalized spatial coding in the medial prefrontal cortex is inherited from
    spatial representations in the hippocampus, and that the routing of information
    can change dynamically with behavioral demands.
acknowledgement: We thank Federico Stella for invaluable suggestions and discussions.
  We thank Yosman BapatDhar and Andrea Cumpelik for comments, help and suggestions
  on the exposure of the text. We thank Predrag Živadinović and Juliana Couras for
  comments on the text and the figures. This work was supported by the EU-FP7 MC-ITN
  IN-SENS (grant 607616).
article_processing_charge: No
author:
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
- first_name: Karola
  full_name: Käfer, Karola
  id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
  last_name: Käfer
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
    the prefrontal cortex is inherited from the hippocampus. <i>bioRxiv</i>. doi:<a
    href="https://doi.org/10.1101/2021.09.30.462269">10.1101/2021.09.30.462269</a>
  apa: Nardin, M., Käfer, K., &#38; Csicsvari, J. L. (n.d.). The generalized spatial
    representation in the prefrontal cortex is inherited from the hippocampus. <i>bioRxiv</i>.
    Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/2021.09.30.462269">https://doi.org/10.1101/2021.09.30.462269</a>
  chicago: Nardin, Michele, Karola Käfer, and Jozsef L Csicsvari. “The Generalized
    Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.”
    <i>BioRxiv</i>. Cold Spring Harbor Laboratory, n.d. <a href="https://doi.org/10.1101/2021.09.30.462269">https://doi.org/10.1101/2021.09.30.462269</a>.
  ieee: M. Nardin, K. Käfer, and J. L. Csicsvari, “The generalized spatial representation
    in the prefrontal cortex is inherited from the hippocampus,” <i>bioRxiv</i>. Cold
    Spring Harbor Laboratory.
  ista: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
    the prefrontal cortex is inherited from the hippocampus. bioRxiv, <a href="https://doi.org/10.1101/2021.09.30.462269">10.1101/2021.09.30.462269</a>.
  mla: Nardin, Michele, et al. “The Generalized Spatial Representation in the Prefrontal
    Cortex Is Inherited from the Hippocampus.” <i>BioRxiv</i>, Cold Spring Harbor
    Laboratory, doi:<a href="https://doi.org/10.1101/2021.09.30.462269">10.1101/2021.09.30.462269</a>.
  short: M. Nardin, K. Käfer, J.L. Csicsvari, BioRxiv (n.d.).
date_created: 2021-10-04T06:28:32Z
date_published: 2021-10-02T00:00:00Z
date_updated: 2025-04-15T06:48:21Z
day: '02'
department:
- _id: GradSch
- _id: JoCs
doi: 10.1101/2021.09.30.462269
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2021.09.30.462269
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '607616'
  name: inter-and intracellular signalling in schizophrenia
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
status: public
title: The generalized spatial representation in the prefrontal cortex is inherited
  from the hippocampus
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...