article published yes Martin Obr author 4741CA5A-F248-11E8-B48F-1D18A9856A870000-0003-1756-6564 Florian KM Schur author 48AD8942-F248-11E8-B48F-1D18A9856A870000-0003-4790-8078 Robert A. Dick author FlSc department Structural conservation and diversity in retroviral capsid project The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 binding site, and enhances core stability, creating a favorable environment for reverse transcription. IP6 also enhances assembly of other retroviruses, from both the Lentivirus and the Alpharetrovirus genera. These findings suggest that IP6 may have a conserved function throughout the family Retroviridae. Here, we discuss the different steps in the viral life cycle that are influenced by IP6, and describe in detail how IP6 interacts with the immature and mature lattices of different retroviruses. https://research-explorer.ista.ac.at/download/10103/10115/2021_Viruses_Obr.pdf application/pdfno MDPI2021 eng virologyinfectious diseases 1999-4915 34578434 00069984110000110.3390/v13091853 139 Obr, Martin, Florian KM Schur, and Robert A. Dick. “A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.” <i>Viruses</i>. MDPI, 2021. <a href="https://doi.org/10.3390/v13091853">https://doi.org/10.3390/v13091853</a>. Obr M, Schur FK, Dick RA. 2021. A structural perspective of the role of IP6 in immature and mature retroviral assembly. Viruses. 13(9), 1853. Obr M, Schur FK, Dick RA. A structural perspective of the role of IP6 in immature and mature retroviral assembly. <i>Viruses</i>. 2021;13(9). doi:<a href="https://doi.org/10.3390/v13091853">10.3390/v13091853</a> Obr, M., Schur, F. K., &#38; Dick, R. A. (2021). A structural perspective of the role of IP6 in immature and mature retroviral assembly. <i>Viruses</i>. MDPI. <a href="https://doi.org/10.3390/v13091853">https://doi.org/10.3390/v13091853</a> M. Obr, F.K. Schur, R.A. Dick, Viruses 13 (2021). Obr, Martin, et al. “A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.” <i>Viruses</i>, vol. 13, no. 9, 1853, MDPI, 2021, doi:<a href="https://doi.org/10.3390/v13091853">10.3390/v13091853</a>. M. Obr, F. K. Schur, and R. A. Dick, “A structural perspective of the role of IP6 in immature and mature retroviral assembly,” <i>Viruses</i>, vol. 13, no. 9. MDPI, 2021. 101032021-10-07T09:13:29Z2025-04-15T08:24:49Z