--- res: bibo_abstract: - The ubiquitous Ca2+ sensor calmodulin (CaM) binds and regulates many proteins, including ion channels, CaM kinases, and calcineurin, according to Ca2+-CaM levels. What regulates neuronal CaM levels, is, however, unclear. CaM-binding transcription activators (CAMTAs) are ancient proteins expressed broadly in nervous systems and whose loss confers pleiotropic behavioral defects in flies, mice, and humans. Using Caenorhabditis elegans and Drosophila, we show that CAMTAs control neuronal CaM levels. The behavioral and neuronal Ca2+ signaling defects in mutants lacking camt-1, the sole C. elegans CAMTA, can be rescued by supplementing neuronal CaM. CAMT-1 binds multiple sites in the CaM promoter and deleting these sites phenocopies camt-1. Our data suggest CAMTAs mediate a conserved and general mechanism that controls neuronal CaM levels, thereby regulating Ca2+ signaling, physiology, and behavior.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Thanh foaf_name: Vuong-Brender, Thanh foaf_surname: Vuong-Brender foaf_workInfoHomepage: http://www.librecat.org/personId=D389312E-10C4-11EA-ABF4-A4B43DDC885E - foaf_Person: foaf_givenName: Sean foaf_name: Flynn, Sean foaf_surname: Flynn - foaf_Person: foaf_givenName: Yvonne foaf_name: Vallis, Yvonne foaf_surname: Vallis foaf_workInfoHomepage: http://www.librecat.org/personId=05A2795C-31B5-11EA-83A7-7DA23DDC885E - foaf_Person: foaf_givenName: Mario foaf_name: De Bono, Mario foaf_surname: De Bono foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8347-0443 bibo_doi: 10.7554/eLife.68238 bibo_volume: 10 dct_date: 2021^xs_gYear dct_identifier: - UT:000695716100001 dct_isPartOf: - http://id.crossref.org/issn/2050-084X dct_language: eng dct_publisher: eLife Sciences Publications@ dct_title: Neuronal calmodulin levels are controlled by CAMTA transcription factors@ fabio_hasPubmedId: '34499028' ...