{"_id":"10124","abstract":[{"text":"The transport of macromolecules and nanoscopic particles to a target cellular site is a crucial aspect in many physiological processes. This directional motion is generally controlled via active mechanical and chemical processes. Here we show, by means of molecular dynamics simulations and an analytical theory, that completely passive nanoparticles can exhibit directional motion when embedded in non-uniform mechanical environments. Specifically, we study the motion of a passive nanoparticle adhering to a mechanically non-uniform elastic membrane. We observe a non-monotonic affinity of the particle to the membrane as a function of the membrane’s rigidity, which results in the particle transport. This transport can be both up or down the rigidity gradient, depending on the absolute values of the rigidities that the gradient spans across. We conclude that rigidity gradients can be used to direct average motion of passive macromolecules and nanoparticles on deformable membranes, resulting in the preferential accumulation of the macromolecules in regions of certain mechanical properties.","lang":"eng"}],"publication":"ACS Nano","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2021.04.01.438065"}],"pmid":1,"date_updated":"2021-10-12T09:50:19Z","quality_controlled":"1","acknowledgement":"We acknowledge support from the Engineering and Physical Sciences Research Council (A.P. and A.Š.), the Royal Society (A.Š.) and the European Research Council (I.P. and A.Š.).","author":[{"last_name":"Palaia","full_name":"Palaia, Ivan","first_name":"Ivan"},{"first_name":"Alexandru","full_name":"Paraschiv, Alexandru","last_name":"Paraschiv"},{"first_name":"Vincent","full_name":"Debets, Vincent","last_name":"Debets"},{"first_name":"Cornelis","full_name":"Storm, Cornelis","last_name":"Storm"},{"orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","last_name":"Šarić","full_name":"Šarić, Anđela"}],"citation":{"short":"I. Palaia, A. Paraschiv, V. Debets, C. Storm, A. Šarić, ACS Nano (2021).","ama":"Palaia I, Paraschiv A, Debets V, Storm C, Šarić A. Durotaxis of passive nanoparticles on elastic membranes. <i>ACS Nano</i>. 2021. doi:<a href=\"https://doi.org/10.1021/acsnano.1c02777 \">10.1021/acsnano.1c02777 </a>","ista":"Palaia I, Paraschiv A, Debets V, Storm C, Šarić A. 2021. Durotaxis of passive nanoparticles on elastic membranes. ACS Nano.","ieee":"I. Palaia, A. Paraschiv, V. Debets, C. Storm, and A. Šarić, “Durotaxis of passive nanoparticles on elastic membranes,” <i>ACS Nano</i>. American Chemical Society, 2021.","apa":"Palaia, I., Paraschiv, A., Debets, V., Storm, C., &#38; Šarić, A. (2021). Durotaxis of passive nanoparticles on elastic membranes. <i>ACS Nano</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsnano.1c02777 \">https://doi.org/10.1021/acsnano.1c02777 </a>","mla":"Palaia, Ivan, et al. “Durotaxis of Passive Nanoparticles on Elastic Membranes.” <i>ACS Nano</i>, American Chemical Society, 2021, doi:<a href=\"https://doi.org/10.1021/acsnano.1c02777 \">10.1021/acsnano.1c02777 </a>.","chicago":"Palaia, Ivan, Alexandru Paraschiv, Vincent Debets, Cornelis Storm, and Anđela Šarić. “Durotaxis of Passive Nanoparticles on Elastic Membranes.” <i>ACS Nano</i>. American Chemical Society, 2021. <a href=\"https://doi.org/10.1021/acsnano.1c02777 \">https://doi.org/10.1021/acsnano.1c02777 </a>."},"doi":"10.1021/acsnano.1c02777 ","external_id":{"pmid":["34550677 "]},"extern":"1","title":"Durotaxis of passive nanoparticles on elastic membranes","publication_status":"published","status":"public","article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_type":"original","oa":1,"date_created":"2021-10-12T07:31:21Z","language":[{"iso":"eng"}],"oa_version":"Preprint","date_published":"2021-09-22T00:00:00Z","month":"09","publisher":"American Chemical Society","year":"2021","type":"journal_article","day":"22"}