---
res:
  bibo_abstract:
  - Schistosomes, the human parasites responsible for snail fever, are female-heterogametic.
    Different parts of their ZW sex chromosomes have stopped recombining in distinct
    lineages, creating “evolutionary strata” of various ages. Although the Z-chromosome
    is well characterized at the genomic and molecular level, the W-chromosome has
    remained largely unstudied from an evolutionary perspective, as only a few W-linked
    genes have been detected outside of the model species Schistosoma mansoni. Here,
    we characterize the gene content and evolution of the W-chromosomes of S. mansoni
    and of the divergent species S. japonicum. We use a combined RNA/DNA k-mer based
    pipeline to assemble around 100 candidate W-specific transcripts in each of the
    species. About half of them map to known protein coding genes, the majority homologous
    to S. mansoni Z-linked genes. We perform an extended analysis of the evolutionary
    strata present in the two species (including characterizing a previously undetected
    young stratum in S. japonicum) to infer patterns of sequence and expression evolution
    of W-linked genes at different time points after recombination was lost. W-linked
    genes show evidence of degeneration, including high rates of protein evolution
    and reduced expression. Most are found in young lineage-specific strata, with
    only a few high expression ancestral W-genes remaining, consistent with the progressive
    erosion of nonrecombining regions. Among these, the splicing factor u2af2 stands
    out as a promising candidate for primary sex determination, opening new avenues
    for understanding the molecular basis of the reproductive biology of this group.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Marwan N
      foaf_name: Elkrewi, Marwan N
      foaf_surname: Elkrewi
      foaf_workInfoHomepage: http://www.librecat.org/personId=0B46FACA-A8E1-11E9-9BD3-79D1E5697425
    orcid: 0000-0002-5328-7231
  - foaf_Person:
      foaf_givenName: Mikhail A.
      foaf_name: Moldovan, Mikhail A.
      foaf_surname: Moldovan
      foaf_workInfoHomepage: http://www.librecat.org/personId=c8bb7f32-3315-11ec-b58b-e5950e6c14a0
    orcid: 0000-0002-8876-6494
  - foaf_Person:
      foaf_givenName: Marion A L
      foaf_name: Picard, Marion A L
      foaf_surname: Picard
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C921A7A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8101-2518
  - foaf_Person:
      foaf_givenName: Beatriz
      foaf_name: Vicoso, Beatriz
      foaf_surname: Vicoso
      foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4579-8306
  bibo_doi: 10.1093/molbev/msab178
  bibo_issue: '12'
  bibo_volume: 138
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000741368600009
  dct_isPartOf:
  - http://id.crossref.org/issn/0737-4038
  - http://id.crossref.org/issn/1537-1719
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_subject:
  - sex chromosomes
  - evolutionary strata
  - W-linked gene
  - sex determining gene
  - schistosome parasites
  dct_title: Schistosome W-linked genes inform temporal dynamics of sex chromosome
    evolution and suggest candidate for sex determination@
  fabio_hasPubmedId: '34146097'
...