---
_id: '10270'
abstract:
- lang: eng
  text: Plants develop new organs to adjust their bodies to dynamic changes in the
    environment. How independent organs achieve anisotropic shapes and polarities
    is poorly understood. To address this question, we constructed a mechano-biochemical
    model for Arabidopsis root meristem growth that integrates biologically plausible
    principles. Computer model simulations demonstrate how differential growth of
    neighboring tissues results in the initial symmetry-breaking leading to anisotropic
    root growth. Furthermore, the root growth feeds back on a polar transport network
    of the growth regulator auxin. Model, predictions are in close agreement with
    in vivo patterns of anisotropic growth, auxin distribution, and cell polarity,
    as well as several root phenotypes caused by chemical, mechanical, or genetic
    perturbations. Our study demonstrates that the combination of tissue mechanics
    and polar auxin transport organizes anisotropic root growth and cell polarities
    during organ outgrowth. Therefore, a mobile auxin signal transported through immobile
    cells drives polarity and growth mechanics to coordinate complex organ development.
acknowledgement: 'e are grateful Richard Smith, Anne-Lise Routier, Crisanto Gutierrez
  and Juergen Kleine-Vehn for providing critical comments on the manuscript. Funding:
  This work was supported by the Programa de Atraccion de Talento 2017 (Comunidad
  de Madrid, 2017-T1/BIO-5654 to KW), Severo Ochoa (SO) Programme for Centres of Excellence
  in R&D from the Agencia Estatal de Investigacion of Spain (grant SEV-2016–0672 (2017–2021)
  to KW via the CBGP). In the frame of SEV-2016–0672 funding MM is supported with
  a postdoctoral contract. KW was supported by Programa Estatal de Generacion del
  Conocimiento y Fortalecimiento Cientıfico y Tecnologico del Sistema de I + D + I
  2019 (PGC2018-093387-A-I00) from MICIU (to KW). MG is recipient of an IST Interdisciplinary
  Project (IC1022IPC03).'
article_number: '72132'
article_processing_charge: Yes
article_type: original
author:
- first_name: Marco
  full_name: Marconi, Marco
  last_name: Marconi
- first_name: Marçal
  full_name: Gallemi, Marçal
  id: 460C6802-F248-11E8-B48F-1D18A9856A87
  last_name: Gallemi
  orcid: 0000-0003-4675-6893
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Krzysztof
  full_name: Wabnik, Krzysztof
  last_name: Wabnik
citation:
  ama: Marconi M, Gallemi M, Benková E, Wabnik K. A coupled mechano-biochemical model
    for cell polarity guided anisotropic root growth. <i>eLife</i>. 2021;10. doi:<a
    href="https://doi.org/10.7554/elife.72132">10.7554/elife.72132</a>
  apa: Marconi, M., Gallemi, M., Benková, E., &#38; Wabnik, K. (2021). A coupled mechano-biochemical
    model for cell polarity guided anisotropic root growth. <i>ELife</i>. eLife Sciences
    Publications. <a href="https://doi.org/10.7554/elife.72132">https://doi.org/10.7554/elife.72132</a>
  chicago: Marconi, Marco, Marçal Gallemi, Eva Benková, and Krzysztof Wabnik. “A Coupled
    Mechano-Biochemical Model for Cell Polarity Guided Anisotropic Root Growth.” <i>ELife</i>.
    eLife Sciences Publications, 2021. <a href="https://doi.org/10.7554/elife.72132">https://doi.org/10.7554/elife.72132</a>.
  ieee: M. Marconi, M. Gallemi, E. Benková, and K. Wabnik, “A coupled mechano-biochemical
    model for cell polarity guided anisotropic root growth,” <i>eLife</i>, vol. 10.
    eLife Sciences Publications, 2021.
  ista: Marconi M, Gallemi M, Benková E, Wabnik K. 2021. A coupled mechano-biochemical
    model for cell polarity guided anisotropic root growth. eLife. 10, 72132.
  mla: Marconi, Marco, et al. “A Coupled Mechano-Biochemical Model for Cell Polarity
    Guided Anisotropic Root Growth.” <i>ELife</i>, vol. 10, 72132, eLife Sciences
    Publications, 2021, doi:<a href="https://doi.org/10.7554/elife.72132">10.7554/elife.72132</a>.
  short: M. Marconi, M. Gallemi, E. Benková, K. Wabnik, ELife 10 (2021).
date_created: 2021-11-11T10:05:18Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:49:23Z
day: '01'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.7554/elife.72132
external_id:
  isi:
  - '000734671200001'
  pmid:
  - '34723798'
file:
- access_level: open_access
  checksum: fad13c509b53bb7a2bef9c946a7ca60a
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-13T09:00:29Z
  date_updated: 2022-05-13T09:00:29Z
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  file_name: 2021_eLife_Marconi.pdf
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file_date_updated: 2022-05-13T09:00:29Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
  issn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: A coupled mechano-biochemical model for cell polarity guided anisotropic root
  growth
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...