---
res:
  bibo_abstract:
  - To survive elevated temperatures, ectotherms adjust the fluidity of membranes
    by fine-tuning lipid desaturation levels in a process previously described to
    be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal
    heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock
    response (HSR), causes extensive fat remodeling in peripheral tissues. These changes
    include a decrease in fat desaturase and acid lipase expression in the intestine
    and a global shift in the saturation levels of plasma membrane’s phospholipids.
    The observed remodeling of plasma membrane is in line with ectothermic adaptive
    responses and gives worms a cumulative advantage to warm temperatures. We have
    determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated
    channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone
    morphogenetic protein (BMP) are required for signaling across tissues to modulate
    fat desaturation. We also find neuronal hsf-1 is not only sufficient but also
    partially necessary to control the fat remodeling response and for survival at
    warm temperatures. This is the first study to show that a thermostat-based mechanism
    can cell nonautonomously coordinate membrane saturation and composition across
    tissues in a multicellular animal.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Laetitia
      foaf_name: Chauve, Laetitia
      foaf_surname: Chauve
  - foaf_Person:
      foaf_givenName: Francesca
      foaf_name: Hodge, Francesca
      foaf_surname: Hodge
  - foaf_Person:
      foaf_givenName: Sharlene
      foaf_name: Murdoch, Sharlene
      foaf_surname: Murdoch
  - foaf_Person:
      foaf_givenName: Fatemah
      foaf_name: Masoudzadeh, Fatemah
      foaf_surname: Masoudzadeh
  - foaf_Person:
      foaf_givenName: Harry Jack
      foaf_name: Mann, Harry Jack
      foaf_surname: Mann
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Lopez-Clavijo, Andrea
      foaf_surname: Lopez-Clavijo
  - foaf_Person:
      foaf_givenName: Hanneke
      foaf_name: Okkenhaug, Hanneke
      foaf_surname: Okkenhaug
  - foaf_Person:
      foaf_givenName: Greg
      foaf_name: West, Greg
      foaf_surname: West
  - foaf_Person:
      foaf_givenName: Bebiana C.
      foaf_name: Sousa, Bebiana C.
      foaf_surname: Sousa
  - foaf_Person:
      foaf_givenName: Anne
      foaf_name: Segonds-Pichon, Anne
      foaf_surname: Segonds-Pichon
  - foaf_Person:
      foaf_givenName: Cheryl
      foaf_name: Li, Cheryl
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Steven
      foaf_name: Wingett, Steven
      foaf_surname: Wingett
  - foaf_Person:
      foaf_givenName: Hermine
      foaf_name: Kienberger, Hermine
      foaf_surname: Kienberger
  - foaf_Person:
      foaf_givenName: Karin
      foaf_name: Kleigrewe, Karin
      foaf_surname: Kleigrewe
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: De Bono, Mario
      foaf_surname: De Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Wakelam, Michael
      foaf_surname: Wakelam
  - foaf_Person:
      foaf_givenName: Olivia
      foaf_name: Casanueva, Olivia
      foaf_surname: Casanueva
  bibo_doi: 10.1371/journal.pbio.3001431
  bibo_issue: '11'
  bibo_volume: 19
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000715818400001
  dct_isPartOf:
  - http://id.crossref.org/issn/1544-9173
  - http://id.crossref.org/issn/1545-7885
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Neuronal HSF-1 coordinates the propagation of fat desaturation across
    tissues to enable adaptation to high temperatures in C. elegans@
  fabio_hasPubmedId: '34723964'
...