---
_id: '10322'
abstract:
- lang: eng
  text: To survive elevated temperatures, ectotherms adjust the fluidity of membranes
    by fine-tuning lipid desaturation levels in a process previously described to
    be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal
    heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock
    response (HSR), causes extensive fat remodeling in peripheral tissues. These changes
    include a decrease in fat desaturase and acid lipase expression in the intestine
    and a global shift in the saturation levels of plasma membrane’s phospholipids.
    The observed remodeling of plasma membrane is in line with ectothermic adaptive
    responses and gives worms a cumulative advantage to warm temperatures. We have
    determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated
    channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone
    morphogenetic protein (BMP) are required for signaling across tissues to modulate
    fat desaturation. We also find neuronal hsf-1 is not only sufficient but also
    partially necessary to control the fat remodeling response and for survival at
    warm temperatures. This is the first study to show that a thermostat-based mechanism
    can cell nonautonomously coordinate membrane saturation and composition across
    tissues in a multicellular animal.
acknowledgement: We dedicate this work to the memory of Michael J.O. Wakelam. We would
  like to acknowledge Michael Fasseas (Invermis, Magnitude Biosciences) for plasmid
  injections and Sunny Biotech for transgenics; Catalina Vallejos and John Marioni
  for statistical advice at the beginning of the work; Simon Walker, Imaging, Bioinformatics
  and Lipidomics Facilities at Babraham Institute for technical support; and Cindy
  Voisine, Michael Witting, Jon Houseley, Len Stephens, Carmen Nussbaum Krammer, Rebeca
  Aldunate, Patricija van Oosten-Hawle, Jean-Louis Bessereau, and Jane Alfred for
  feedback on the manuscript. We thank Andy Dillin, Atsushi Kuhara, Amy Walker, Andrew
  Leifer, Yun Zhang, and Michalis Barkoulas for reagents and Julie Ahringer, Anne
  Ferguson-Smith, and Anne Corcoran for support and helpful discussions. We also acknowledge
  Babraham Institute Facilities.
article_number: e3001431
article_processing_charge: No
article_type: original
author:
- first_name: Laetitia
  full_name: Chauve, Laetitia
  last_name: Chauve
- first_name: Francesca
  full_name: Hodge, Francesca
  last_name: Hodge
- first_name: Sharlene
  full_name: Murdoch, Sharlene
  last_name: Murdoch
- first_name: Fatemah
  full_name: Masoudzadeh, Fatemah
  last_name: Masoudzadeh
- first_name: Harry Jack
  full_name: Mann, Harry Jack
  last_name: Mann
- first_name: Andrea
  full_name: Lopez-Clavijo, Andrea
  last_name: Lopez-Clavijo
- first_name: Hanneke
  full_name: Okkenhaug, Hanneke
  last_name: Okkenhaug
- first_name: Greg
  full_name: West, Greg
  last_name: West
- first_name: Bebiana C.
  full_name: Sousa, Bebiana C.
  last_name: Sousa
- first_name: Anne
  full_name: Segonds-Pichon, Anne
  last_name: Segonds-Pichon
- first_name: Cheryl
  full_name: Li, Cheryl
  last_name: Li
- first_name: Steven
  full_name: Wingett, Steven
  last_name: Wingett
- first_name: Hermine
  full_name: Kienberger, Hermine
  last_name: Kienberger
- first_name: Karin
  full_name: Kleigrewe, Karin
  last_name: Kleigrewe
- first_name: Mario
  full_name: De Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: De Bono
  orcid: 0000-0001-8347-0443
- first_name: Michael
  full_name: Wakelam, Michael
  last_name: Wakelam
- first_name: Olivia
  full_name: Casanueva, Olivia
  last_name: Casanueva
citation:
  ama: Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation
    of fat desaturation across tissues to enable adaptation to high temperatures in
    C. elegans. <i>PLoS Biology</i>. 2021;19(11). doi:<a href="https://doi.org/10.1371/journal.pbio.3001431">10.1371/journal.pbio.3001431</a>
  apa: Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H. J., Lopez-Clavijo,
    A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat
    desaturation across tissues to enable adaptation to high temperatures in C. elegans.
    <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.3001431">https://doi.org/10.1371/journal.pbio.3001431</a>
  chicago: Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh,
    Harry Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1
    Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation
    to High Temperatures in C. Elegans.” <i>PLoS Biology</i>. Public Library of Science,
    2021. <a href="https://doi.org/10.1371/journal.pbio.3001431">https://doi.org/10.1371/journal.pbio.3001431</a>.
  ieee: L. Chauve <i>et al.</i>, “Neuronal HSF-1 coordinates the propagation of fat
    desaturation across tissues to enable adaptation to high temperatures in C. elegans,”
    <i>PLoS Biology</i>, vol. 19, no. 11. Public Library of Science, 2021.
  ista: Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann HJ, Lopez-Clavijo A, Okkenhaug
    H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe
    K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation
    of fat desaturation across tissues to enable adaptation to high temperatures in
    C. elegans. PLoS Biology. 19(11), e3001431.
  mla: Chauve, Laetitia, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat
    Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.”
    <i>PLoS Biology</i>, vol. 19, no. 11, e3001431, Public Library of Science, 2021,
    doi:<a href="https://doi.org/10.1371/journal.pbio.3001431">10.1371/journal.pbio.3001431</a>.
  short: L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.J. Mann, A. Lopez-Clavijo,
    H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger,
    K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, PLoS Biology 19 (2021).
date_created: 2021-11-21T23:01:28Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:53:27Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1371/journal.pbio.3001431
external_id:
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publication: PLoS Biology
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publication_status: published
publisher: Public Library of Science
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scopus_import: '1'
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title: Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues
  to enable adaptation to high temperatures in C. elegans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2021'
...