article published yes Christian Vanhille-Campos author Anđela Šarić author bf63d406-f056-11eb-b41d-f263a6566d8b0000-0002-7854-2139 We study the effects of osmotic shocks on lipid vesicles via coarse-grained molecular dynamics simulations by explicitly considering the solute in the system. We find that depending on their nature (hypo- or hypertonic) such shocks can lead to bursting events or engulfing of external material into inner compartments, among other morphology transformations. We characterize the dynamics of these processes and observe a separation of time scales between the osmotic shock absorption and the shape relaxation. Our work consequently provides an insight into the dynamics of compartmentalization in vesicular systems as a result of osmotic shocks, which can be of interest in the context of early proto-cell development and proto-cell compartmentalisation. https://creativecommons.org/licenses/by-nc/3.0/ Royal Society of Chemistry2021 eng condensed matter physicsgeneral chemistry 1744-683X 1744-6848 3362908910.1039/d0sm02012e 17143798-3806 https://www.biorxiv.org/content/10.1101/2020.11.16.384602v2 yes Vanhille-Campos C, Šarić A. Modelling the dynamics of vesicle reshaping and scission under osmotic shocks. <i>Soft Matter</i>. 2021;17(14):3798-3806. doi:<a href="https://doi.org/10.1039/d0sm02012e">10.1039/d0sm02012e</a> Vanhille-Campos C, Šarić A. 2021. Modelling the dynamics of vesicle reshaping and scission under osmotic shocks. Soft Matter. 17(14), 3798–3806. Vanhille-Campos, Christian, and Anđela Šarić. “Modelling the Dynamics of Vesicle Reshaping and Scission under Osmotic Shocks.” <i>Soft Matter</i>, vol. 17, no. 14, Royal Society of Chemistry, 2021, pp. 3798–806, doi:<a href="https://doi.org/10.1039/d0sm02012e">10.1039/d0sm02012e</a>. C. Vanhille-Campos and A. Šarić, “Modelling the dynamics of vesicle reshaping and scission under osmotic shocks,” <i>Soft Matter</i>, vol. 17, no. 14. Royal Society of Chemistry, pp. 3798–3806, 2021. Vanhille-Campos, C., &#38; Šarić, A. (2021). Modelling the dynamics of vesicle reshaping and scission under osmotic shocks. <i>Soft Matter</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d0sm02012e">https://doi.org/10.1039/d0sm02012e</a> C. Vanhille-Campos, A. Šarić, Soft Matter 17 (2021) 3798–3806. Vanhille-Campos, Christian, and Anđela Šarić. “Modelling the Dynamics of Vesicle Reshaping and Scission under Osmotic Shocks.” <i>Soft Matter</i>. Royal Society of Chemistry, 2021. <a href="https://doi.org/10.1039/d0sm02012e">https://doi.org/10.1039/d0sm02012e</a>. 103392021-11-25T16:06:42Z2024-10-14T14:20:59Z