--- res: bibo_abstract: - Biological membranes typically contain a large number of different components dispersed in small concentrations in the main membrane phase, including proteins, sugars, and lipids of varying geometrical properties. Most of these components do not bind the cargo. Here, we show that such “inert” components can be crucial for the precise control of cross-membrane trafficking. Using a statistical mechanics model and molecular dynamics simulations, we demonstrate that the presence of inert membrane components of small isotropic curvatures dramatically influences cargo endocytosis, even if the total spontaneous curvature of such a membrane remains unchanged. Curved lipids, such as cholesterol, as well as asymmetrically included proteins and tethered sugars can, therefore, actively participate in the control of the membrane trafficking of nanoscopic cargo. We find that even a low-level expression of curved inert membrane components can determine the membrane selectivity toward the cargo size and can be used to selectively target membranes of certain compositions. Our results suggest a robust and general method of controlling cargo trafficking by adjusting the membrane composition without needing to alter the concentration of receptors or the average membrane curvature. This study indicates that cells can prepare for any trafficking event by incorporating curved inert components in either of the membrane leaflets.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Tine foaf_name: Curk, Tine foaf_surname: Curk - foaf_Person: foaf_givenName: Peter foaf_name: Wirnsberger, Peter foaf_surname: Wirnsberger - foaf_Person: foaf_givenName: Jure foaf_name: Dobnikar, Jure foaf_surname: Dobnikar - foaf_Person: foaf_givenName: Daan foaf_name: Frenkel, Daan foaf_surname: Frenkel - foaf_Person: foaf_givenName: Anđela foaf_name: Šarić, Anđela foaf_surname: Šarić foaf_workInfoHomepage: http://www.librecat.org/personId=bf63d406-f056-11eb-b41d-f263a6566d8b orcid: 0000-0002-7854-2139 bibo_doi: 10.1021/acs.nanolett.8b00786 bibo_issue: '9' bibo_volume: 18 dct_date: 2018^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/1530-6984 - http://id.crossref.org/issn/1530-6992 dct_language: eng dct_publisher: American Chemical Society@ dct_subject: - mechanical engineering - condensed matter physics dct_title: Controlling cargo trafficking in multicomponent membranes@ fabio_hasPubmedId: '29667410' ...