{"doi":"10.1021/acs.nanolett.8b00786","article_type":"original","page":"5350-5356","type":"journal_article","acknowledgement":"We acknowledge discussions with Giuseppe Battaglia as well as support from the Herchel Smith scholarship (T.C.), the CAS PIFI fellowship (T.C.), the UCL Institute for the Physics of Living Systems (T.C. and A.Š.), the Austrian Academy of Sciences through a DOC fellowship (P.W.), the European Union Horizon 2020 programme under ETN grant no. 674979-NANOTRANS and FET grant no. 766972-NANOPHLOW (J.D. and D.F.), the Engineering and Physical Sciences Research Council (D.F. and A.Š.), the Academy of Medical Sciences and Wellcome Trust (A.Š.), and the Royal Society (A.Š.). We thank Claudia Flandoli for help with Figure 1.","issue":"9","author":[{"full_name":"Curk, Tine","last_name":"Curk","first_name":"Tine"},{"first_name":"Peter","last_name":"Wirnsberger","full_name":"Wirnsberger, Peter"},{"last_name":"Dobnikar","first_name":"Jure","full_name":"Dobnikar, Jure"},{"full_name":"Frenkel, Daan","first_name":"Daan","last_name":"Frenkel"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","first_name":"Anđela"}],"status":"public","external_id":{"pmid":["29667410"]},"date_updated":"2021-11-26T15:14:08Z","oa_version":"Preprint","year":"2018","month":"04","publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1712.10147"}],"keyword":["mechanical engineering","condensed matter physics"],"title":"Controlling cargo trafficking in multicomponent membranes","quality_controlled":"1","extern":"1","date_published":"2018-04-18T00:00:00Z","citation":{"chicago":"Curk, Tine, Peter Wirnsberger, Jure Dobnikar, Daan Frenkel, and Anđela Šarić. “Controlling Cargo Trafficking in Multicomponent Membranes.” <i>Nano Letters</i>. American Chemical Society, 2018. <a href=\"https://doi.org/10.1021/acs.nanolett.8b00786\">https://doi.org/10.1021/acs.nanolett.8b00786</a>.","apa":"Curk, T., Wirnsberger, P., Dobnikar, J., Frenkel, D., &#38; Šarić, A. (2018). Controlling cargo trafficking in multicomponent membranes. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.8b00786\">https://doi.org/10.1021/acs.nanolett.8b00786</a>","ista":"Curk T, Wirnsberger P, Dobnikar J, Frenkel D, Šarić A. 2018. Controlling cargo trafficking in multicomponent membranes. Nano Letters. 18(9), 5350–5356.","mla":"Curk, Tine, et al. “Controlling Cargo Trafficking in Multicomponent Membranes.” <i>Nano Letters</i>, vol. 18, no. 9, American Chemical Society, 2018, pp. 5350–56, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.8b00786\">10.1021/acs.nanolett.8b00786</a>.","short":"T. Curk, P. Wirnsberger, J. Dobnikar, D. Frenkel, A. Šarić, Nano Letters 18 (2018) 5350–5356.","ieee":"T. Curk, P. Wirnsberger, J. Dobnikar, D. Frenkel, and A. Šarić, “Controlling cargo trafficking in multicomponent membranes,” <i>Nano Letters</i>, vol. 18, no. 9. American Chemical Society, pp. 5350–5356, 2018.","ama":"Curk T, Wirnsberger P, Dobnikar J, Frenkel D, Šarić A. Controlling cargo trafficking in multicomponent membranes. <i>Nano Letters</i>. 2018;18(9):5350-5356. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.8b00786\">10.1021/acs.nanolett.8b00786</a>"},"intvolume":"        18","oa":1,"_id":"10359","scopus_import":"1","publication":"Nano Letters","language":[{"iso":"eng"}],"publication_status":"published","date_created":"2021-11-26T12:15:47Z","abstract":[{"text":"Biological membranes typically contain a large number of different components dispersed in small concentrations in the main membrane phase, including proteins, sugars, and lipids of varying geometrical properties. Most of these components do not bind the cargo. Here, we show that such “inert” components can be crucial for the precise control of cross-membrane trafficking. Using a statistical mechanics model and molecular dynamics simulations, we demonstrate that the presence of inert membrane components of small isotropic curvatures dramatically influences cargo endocytosis, even if the total spontaneous curvature of such a membrane remains unchanged. Curved lipids, such as cholesterol, as well as asymmetrically included proteins and tethered sugars can, therefore, actively participate in the control of the membrane trafficking of nanoscopic cargo. We find that even a low-level expression of curved inert membrane components can determine the membrane selectivity toward the cargo size and can be used to selectively target membranes of certain compositions. Our results suggest a robust and general method of controlling cargo trafficking by adjusting the membrane composition without needing to alter the concentration of receptors or the average membrane curvature. This study indicates that cells can prepare for any trafficking event by incorporating curved inert components in either of the membrane leaflets.","lang":"eng"}],"volume":18,"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","day":"18","publisher":"American Chemical Society","pmid":1}