article published yes Anđela Šarić author bf63d406-f056-11eb-b41d-f263a6566d8b0000-0002-7854-2139 Angelo Cacciuto author Using computer simulations, we show that lipid membranes can mediate linear aggregation of spherical nanoparticles binding to it for a wide range of biologically relevant bending rigidities. This result is in net contrast with the isotropic aggregation of nanoparticles on fluid interfaces or the expected clustering of isotropic insertions in biological membranes. We present a phase diagram indicating where linear aggregation is expected and compute explicitly the free-energy barriers associated with linear and isotropic aggregation. Finally, we provide simple scaling arguments to explain this phenomenology. American Physical Society2012 eng general physics and astronomy 0031-9007 1079-7114 1201.0036 2254051310.1103/physrevlett.108.118101 10811 yes Šarić A, Cacciuto A. Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles. <i>Physical Review Letters</i>. 2012;108(11). doi:<a href="https://doi.org/10.1103/physrevlett.108.118101">10.1103/physrevlett.108.118101</a> A. Šarić, A. Cacciuto, Physical Review Letters 108 (2012). Šarić, Anđela, and Angelo Cacciuto. “Fluid Membranes Can Drive Linear Aggregation of Adsorbed Spherical Nanoparticles.” <i>Physical Review Letters</i>. American Physical Society, 2012. <a href="https://doi.org/10.1103/physrevlett.108.118101">https://doi.org/10.1103/physrevlett.108.118101</a>. A. Šarić and A. Cacciuto, “Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles,” <i>Physical Review Letters</i>, vol. 108, no. 11. American Physical Society, 2012. Šarić A, Cacciuto A. 2012. Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles. Physical Review Letters. 108(11), 118101. Šarić, Anđela, and Angelo Cacciuto. “Fluid Membranes Can Drive Linear Aggregation of Adsorbed Spherical Nanoparticles.” <i>Physical Review Letters</i>, vol. 108, no. 11, 118101, American Physical Society, 2012, doi:<a href="https://doi.org/10.1103/physrevlett.108.118101">10.1103/physrevlett.108.118101</a>. Šarić, A., &#38; Cacciuto, A. (2012). Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles. <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevlett.108.118101">https://doi.org/10.1103/physrevlett.108.118101</a> 103882021-11-29T14:30:05Z2021-11-29T15:12:13Z