--- res: bibo_abstract: - Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to such an inquiry in the future.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Nikhil foaf_name: Mishra, Nikhil foaf_surname: Mishra foaf_workInfoHomepage: http://www.librecat.org/personId=C4D70E82-1081-11EA-B3ED-9A4C3DDC885E orcid: 0000-0002-6425-5788 - foaf_Person: foaf_givenName: Carl-Philipp J foaf_name: Heisenberg, Carl-Philipp J foaf_surname: Heisenberg foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-0912-4566 bibo_doi: 10.1146/annurev-genet-071819-103748 bibo_volume: 55 dct_date: 2021^xs_gYear dct_identifier: - UT:000747220900010 dct_isPartOf: - http://id.crossref.org/issn/0066-4197 - http://id.crossref.org/issn/1545-2948 dct_language: eng dct_publisher: Annual Reviews@ dct_subject: - morphogenesis - forward genetics - high-resolution microscopy - biophysics - biochemistry - patterning dct_title: Dissecting organismal morphogenesis by bridging genetics and biophysics@ fabio_hasPubmedId: '34460295' ...