---
res:
  bibo_abstract:
  - How tissues acquire complex shapes is a fundamental question in biology and regenerative
    medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium
    (buds) that extend and fuse to form the hubs of each canal. We find that conventional
    actomyosin-driven behaviors are not required. Instead, local secretion of hyaluronan,
    made by the enzymes uridine 5′-diphosphate dehydrogenase (ugdh) and hyaluronan
    synthase 3 (has3), drives canal morphogenesis. Charged hyaluronate polymers osmotically
    swell with water and generate isotropic extracellular pressure to deform the overlying
    epithelium into buds. The mechanical anisotropy needed to shape buds into tubes
    is conferred by a polarized distribution of actomyosin and E-cadherin-rich membrane
    tethers, which we term cytocinches. Most work on tissue morphogenesis ascribes
    actomyosin contractility as the driving force, while the extracellular matrix
    shapes tissues through differential stiffness. Our work inverts this expectation.
    Hyaluronate pressure shaped by anisotropic tissue stiffness may be a widespread
    mechanism for powering morphological change in organogenesis and tissue engineering.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Akankshi
      foaf_name: Munjal, Akankshi
      foaf_surname: Munjal
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Tony Y.C.
      foaf_name: Tsai, Tony Y.C.
      foaf_surname: Tsai
  - foaf_Person:
      foaf_givenName: Timothy J.
      foaf_name: Mitchison, Timothy J.
      foaf_surname: Mitchison
  - foaf_Person:
      foaf_givenName: Sean G.
      foaf_name: Megason, Sean G.
      foaf_surname: Megason
  bibo_doi: 10.1016/j.cell.2021.11.025
  bibo_issue: '26'
  bibo_volume: 184
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000735387500002
  dct_isPartOf:
  - http://id.crossref.org/issn/0092-8674
  - http://id.crossref.org/issn/1097-4172
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Extracellular hyaluronate pressure shaped by cellular tethers drives
    tissue morphogenesis@
...