---
res:
  bibo_abstract:
  - The infiltration of immune cells into tissues underlies the establishment of tissue-resident
    macrophages and responses to infections and tumors. Yet the mechanisms immune
    cells utilize to negotiate tissue barriers in living organisms are not well understood,
    and a role for cortical actin has not been examined. Here, we find that the tissue
    invasion of Drosophila macrophages, also known as plasmatocytes or hemocytes,
    utilizes enhanced cortical F-actin levels stimulated by the Drosophila member
    of the fos proto oncogene transcription factor family (Dfos, Kayak). RNA sequencing
    analysis and live imaging show that Dfos enhances F-actin levels around the entire
    macrophage surface by increasing mRNA levels of the membrane spanning molecular
    scaffold tetraspanin TM4SF, and the actin cross-linking filamin Cheerio, which
    are themselves required for invasion. Both the filamin and the tetraspanin enhance
    the cortical activity of Rho1 and the formin Diaphanous and thus the assembly
    of cortical actin, which is a critical function since expressing a dominant active
    form of Diaphanous can rescue the Dfos macrophage invasion defect. In vivo imaging
    shows that Dfos enhances the efficiency of the initial phases of macrophage tissue
    entry. Genetic evidence argues that this Dfos-induced program in macrophages counteracts
    the constraint produced by the tension of surrounding tissues and buffers the
    properties of the macrophage nucleus from affecting tissue entry. We thus identify
    strengthening the cortical actin cytoskeleton through Dfos as a key process allowing
    efficient forward movement of an immune cell into surrounding tissues. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Vera
      foaf_name: Belyaeva, Vera
      foaf_surname: Belyaeva
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F080FE-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Stephanie
      foaf_name: Wachner, Stephanie
      foaf_surname: Wachner
      foaf_workInfoHomepage: http://www.librecat.org/personId=2A95E7B0-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Attila
      foaf_name: György, Attila
      foaf_surname: György
      foaf_workInfoHomepage: http://www.librecat.org/personId=3BCEDBE0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1819-198X
  - foaf_Person:
      foaf_givenName: Shamsi
      foaf_name: Emtenani, Shamsi
      foaf_surname: Emtenani
      foaf_workInfoHomepage: http://www.librecat.org/personId=49D32318-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6981-6938
  - foaf_Person:
      foaf_givenName: Igor
      foaf_name: Gridchyn, Igor
      foaf_surname: Gridchyn
      foaf_workInfoHomepage: http://www.librecat.org/personId=4B60654C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1807-1929
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Akhmanova, Maria
      foaf_surname: Akhmanova
      foaf_workInfoHomepage: http://www.librecat.org/personId=3425EC26-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1522-3162
  - foaf_Person:
      foaf_givenName: M
      foaf_name: Linder, M
      foaf_surname: Linder
  - foaf_Person:
      foaf_givenName: Marko
      foaf_name: Roblek, Marko
      foaf_surname: Roblek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3047D808-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9588-1389
  - foaf_Person:
      foaf_givenName: M
      foaf_name: Sibilia, M
      foaf_surname: Sibilia
  - foaf_Person:
      foaf_givenName: Daria E
      foaf_name: Siekhaus, Daria E
      foaf_surname: Siekhaus
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D224B9E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8323-8353
  bibo_doi: 10.1371/journal.pbio.3001494
  bibo_issue: '1'
  bibo_volume: 20
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000971223700001
  dct_isPartOf:
  - http://id.crossref.org/issn/1544-9173
  - http://id.crossref.org/issn/1545-7885
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Fos regulates macrophage infiltration against surrounding tissue resistance
    by a cortical actin-based mechanism in Drosophila@
  fabio_hasPubmedId: '34990456'
...