---
res:
  bibo_abstract:
  - 'Background: Blood-based markers of cognitive functioning might provide an accessible
    way to track neurodegeneration years prior to clinical manifestation of cognitive
    impairment and dementia. Results: Using blood-based epigenome-wide analyses of
    general cognitive function, we show that individual differences in DNA methylation
    (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm
    predictor explains ~4% of the variance, independently of a polygenic score, in
    two external cohorts. It also associates with circulating levels of neurology-
    and inflammation-related proteins, global brain imaging metrics, and regional
    cortical volumes. Conclusions: As sample sizes increase, the ability to assess
    cognitive function from DNAm data may be informative in settings where cognitive
    testing is unreliable or unavailable.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Daniel L.
      foaf_name: McCartney, Daniel L.
      foaf_surname: McCartney
  - foaf_Person:
      foaf_givenName: Robert F.
      foaf_name: Hillary, Robert F.
      foaf_surname: Hillary
  - foaf_Person:
      foaf_givenName: Eleanor L.S.
      foaf_name: Conole, Eleanor L.S.
      foaf_surname: Conole
  - foaf_Person:
      foaf_givenName: Daniel Trejo
      foaf_name: Banos, Daniel Trejo
      foaf_surname: Banos
  - foaf_Person:
      foaf_givenName: Danni A.
      foaf_name: Gadd, Danni A.
      foaf_surname: Gadd
  - foaf_Person:
      foaf_givenName: Rosie M.
      foaf_name: Walker, Rosie M.
      foaf_surname: Walker
  - foaf_Person:
      foaf_givenName: Cliff
      foaf_name: Nangle, Cliff
      foaf_surname: Nangle
  - foaf_Person:
      foaf_givenName: Robin
      foaf_name: Flaig, Robin
      foaf_surname: Flaig
  - foaf_Person:
      foaf_givenName: Archie
      foaf_name: Campbell, Archie
      foaf_surname: Campbell
  - foaf_Person:
      foaf_givenName: Alison D.
      foaf_name: Murray, Alison D.
      foaf_surname: Murray
  - foaf_Person:
      foaf_givenName: Susana Muñoz
      foaf_name: Maniega, Susana Muñoz
      foaf_surname: Maniega
  - foaf_Person:
      foaf_givenName: María Del C.
      foaf_name: Valdés-Hernández, María Del C.
      foaf_surname: Valdés-Hernández
  - foaf_Person:
      foaf_givenName: Mathew A.
      foaf_name: Harris, Mathew A.
      foaf_surname: Harris
  - foaf_Person:
      foaf_givenName: Mark E.
      foaf_name: Bastin, Mark E.
      foaf_surname: Bastin
  - foaf_Person:
      foaf_givenName: Joanna M.
      foaf_name: Wardlaw, Joanna M.
      foaf_surname: Wardlaw
  - foaf_Person:
      foaf_givenName: Sarah E.
      foaf_name: Harris, Sarah E.
      foaf_surname: Harris
  - foaf_Person:
      foaf_givenName: David J.
      foaf_name: Porteous, David J.
      foaf_surname: Porteous
  - foaf_Person:
      foaf_givenName: Elliot M.
      foaf_name: Tucker-Drob, Elliot M.
      foaf_surname: Tucker-Drob
  - foaf_Person:
      foaf_givenName: Andrew M.
      foaf_name: McIntosh, Andrew M.
      foaf_surname: McIntosh
  - foaf_Person:
      foaf_givenName: Kathryn L.
      foaf_name: Evans, Kathryn L.
      foaf_surname: Evans
  - foaf_Person:
      foaf_givenName: Ian J.
      foaf_name: Deary, Ian J.
      foaf_surname: Deary
  - foaf_Person:
      foaf_givenName: Simon R.
      foaf_name: Cox, Simon R.
      foaf_surname: Cox
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  - foaf_Person:
      foaf_givenName: Riccardo E.
      foaf_name: Marioni, Riccardo E.
      foaf_surname: Marioni
  bibo_doi: 10.1186/s13059-021-02596-5
  bibo_issue: '1'
  bibo_volume: 23
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000744358300002
  dct_isPartOf:
  - http://id.crossref.org/issn/1474-7596
  - http://id.crossref.org/issn/1474-760X
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Blood-based epigenome-wide analyses of cognitive abilities@
  fabio_hasPubmedId: '35039062'
...