---
res:
  bibo_abstract:
  - Solute carriers are increasingly recognized as participating in a plethora of
    pathologies, including cancer. We describe here the involvement of the orphan
    solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1
    enabled higher levels of metastasis in a mouse model. We identified an increased
    migratory potential in MFSD1-/- tumor cells which was mediated by increased focal
    adhesion turn-over, reduced stability of mature inactive β1 integrin, and the
    resulting increased integrin activation index. We show that MFSD1 promoted recycling
    to the cell surface of endocytosed inactive β1 integrin and thereby protected
    β1 integrin from proteolytic degradation; this led to dampening of the integrin
    activation index. Furthermore, down-regulation of MFSD1 expression was observed
    during early steps of tumorigenesis and higher MFSD1 expression levels correlate
    with a better cancer patient prognosis. In sum, we describe a requirement for
    endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Marko
      foaf_name: Roblek, Marko
      foaf_surname: Roblek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3047D808-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9588-1389
  - foaf_Person:
      foaf_givenName: Julia
      foaf_name: Bicher, Julia
      foaf_surname: Bicher
      foaf_workInfoHomepage: http://www.librecat.org/personId=3CCBB46E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Merel
      foaf_name: van Gogh, Merel
      foaf_surname: van Gogh
  - foaf_Person:
      foaf_givenName: Attila
      foaf_name: György, Attila
      foaf_surname: György
      foaf_workInfoHomepage: http://www.librecat.org/personId=3BCEDBE0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1819-198X
  - foaf_Person:
      foaf_givenName: Rita
      foaf_name: Seeböck, Rita
      foaf_surname: Seeböck
  - foaf_Person:
      foaf_givenName: Bozena
      foaf_name: Szulc, Bozena
      foaf_surname: Szulc
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Damme, Markus
      foaf_surname: Damme
  - foaf_Person:
      foaf_givenName: Mariusz
      foaf_name: Olczak, Mariusz
      foaf_surname: Olczak
  - foaf_Person:
      foaf_givenName: Lubor
      foaf_name: Borsig, Lubor
      foaf_surname: Borsig
  - foaf_Person:
      foaf_givenName: Daria E
      foaf_name: Siekhaus, Daria E
      foaf_surname: Siekhaus
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D224B9E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8323-8353
  bibo_doi: 10.3389/fonc.2022.777634
  bibo_volume: 12
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000760618800001
  dct_isPartOf:
  - http://id.crossref.org/issn/2234-943X
  dct_language: eng
  dct_publisher: Frontiers@
  dct_title: The solute carrier MFSD1 decreases β1 integrin’s activation status and
    thus tumor metastasis@
  fabio_hasPubmedId: '35211397'
...