{"file":[{"file_size":6303227,"file_id":"10751","content_type":"application/pdf","access_level":"open_access","date_created":"2022-02-08T13:26:40Z","date_updated":"2022-02-08T13:26:40Z","relation":"main_file","checksum":"63dfecf30c5bbf9408b3512bd603f78c","creator":"cchlebak","file_name":"2022_FrontiersOncol_Roblek.pdf","success":1}],"ddc":["570"],"title":"The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis","article_number":"777634","date_created":"2022-02-01T10:33:50Z","has_accepted_license":"1","license":"https://creativecommons.org/licenses/by/4.0/","publisher":"Frontiers","publication_status":"published","language":[{"iso":"eng"}],"month":"02","quality_controlled":"1","acknowledgement":"We thank M. Sixt, A. Leithner, and J. Alanko for helpful advice and the BioImaging Facility at IST Austria for technical support and assistance. We thank the Siekhaus Lab for the careful review of the manuscript and their input. MR and DS were funded by the NO Forschungs- und Bildungsges.m.b.H. (LS16-021) and IST core funding. MD was funded by Deutsche Forschungsgemeinschaft (DA 1785-1).","citation":{"ieee":"M. Roblek <i>et al.</i>, “The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis,” <i>Frontiers in Oncology</i>, vol. 12. Frontiers, 2022.","ista":"Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. 2022. The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. Frontiers in Oncology. 12, 777634.","chicago":"Roblek, Marko, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, and Daria E Siekhaus. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor Metastasis.” <i>Frontiers in Oncology</i>. Frontiers, 2022. <a href=\"https://doi.org/10.3389/fonc.2022.777634\">https://doi.org/10.3389/fonc.2022.777634</a>.","apa":"Roblek, M., Bicher, J., van Gogh, M., György, A., Seeböck, R., Szulc, B., … Siekhaus, D. E. (2022). The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. <i>Frontiers in Oncology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fonc.2022.777634\">https://doi.org/10.3389/fonc.2022.777634</a>","ama":"Roblek M, Bicher J, van Gogh M, et al. The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. <i>Frontiers in Oncology</i>. 2022;12. doi:<a href=\"https://doi.org/10.3389/fonc.2022.777634\">10.3389/fonc.2022.777634</a>","short":"M. Roblek, J. Bicher, M. van Gogh, A. György, R. Seeböck, B. Szulc, M. Damme, M. Olczak, L. Borsig, D.E. Siekhaus, Frontiers in Oncology 12 (2022).","mla":"Roblek, Marko, et al. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor Metastasis.” <i>Frontiers in Oncology</i>, vol. 12, 777634, Frontiers, 2022, doi:<a href=\"https://doi.org/10.3389/fonc.2022.777634\">10.3389/fonc.2022.777634</a>."},"project":[{"grant_number":"LSC16-021 ","_id":"2637E9C0-B435-11E9-9278-68D0E5697425","name":"Investigating the role of the novel major superfamily facilitator transporter family member MFSD1 in metastasis"}],"file_date_updated":"2022-02-08T13:26:40Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2022","related_material":{"link":[{"relation":"confirmation","url":"https://ist.ac.at/en/news/suppressing-the-spread-of-tumors/","description":"News on IST Homepage"}]},"department":[{"_id":"DaSi"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledged_ssus":[{"_id":"Bio"}],"doi":"10.3389/fonc.2022.777634","date_updated":"2023-08-02T14:05:44Z","publication_identifier":{"issn":["2234-943X"]},"abstract":[{"text":"Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1 enabled higher levels of metastasis in a mouse model. We identified an increased migratory potential in MFSD1-/- tumor cells which was mediated by increased focal adhesion turn-over, reduced stability of mature inactive β1 integrin, and the resulting increased integrin activation index. We show that MFSD1 promoted recycling to the cell surface of endocytosed inactive β1 integrin and thereby protected β1 integrin from proteolytic degradation; this led to dampening of the integrin activation index. Furthermore, down-regulation of MFSD1 expression was observed during early steps of tumorigenesis and higher MFSD1 expression levels correlate with a better cancer patient prognosis. In sum, we describe a requirement for endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.","lang":"eng"}],"date_published":"2022-02-08T00:00:00Z","oa":1,"intvolume":"        12","article_processing_charge":"Yes (via OA deal)","author":[{"id":"3047D808-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9588-1389","first_name":"Marko","full_name":"Roblek, Marko","last_name":"Roblek"},{"id":"3CCBB46E-F248-11E8-B48F-1D18A9856A87","full_name":"Bicher, Julia","first_name":"Julia","last_name":"Bicher"},{"last_name":"van Gogh","full_name":"van Gogh, Merel","first_name":"Merel"},{"last_name":"György","full_name":"György, Attila","first_name":"Attila","orcid":"0000-0002-1819-198X","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Rita","full_name":"Seeböck, Rita","last_name":"Seeböck"},{"first_name":"Bozena","full_name":"Szulc, Bozena","last_name":"Szulc"},{"last_name":"Damme","first_name":"Markus","full_name":"Damme, Markus"},{"last_name":"Olczak","first_name":"Mariusz","full_name":"Olczak, Mariusz"},{"first_name":"Lubor","full_name":"Borsig, Lubor","last_name":"Borsig"},{"orcid":"0000-0001-8323-8353","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","last_name":"Siekhaus","full_name":"Siekhaus, Daria E","first_name":"Daria E"}],"oa_version":"Published Version","day":"08","isi":1,"scopus_import":"1","type":"journal_article","_id":"10712","external_id":{"isi":["000760618800001"]},"publication":"Frontiers in Oncology","status":"public","article_type":"original","volume":12}