---
_id: '10713'
abstract:
- lang: eng
  text: Cells migrate through crowded microenvironments within tissues during normal
    development, immune response, and cancer metastasis. Although migration through
    pores and tracks in the extracellular matrix (ECM) has been well studied, little
    is known about cellular traversal into confining cell-dense tissues. We find that
    embryonic tissue invasion by Drosophila macrophages requires division of an epithelial
    ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM
    attachment formed by integrin-mediated focal adhesions next to mesodermal cells,
    allowing macrophages to move their nuclei ahead and invade between two immediately
    adjacent tissues. Invasion efficiency depends on division frequency, but reduction
    of adhesion strength allows macrophage entry independently of division. This work
    demonstrates that tissue dynamics can regulate cellular infiltration.
acknowledged_ssus:
- _id: Bio
acknowledgement: 'We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of
  the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria
  for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly
  strains. This work was supported by a grant from the Austrian Science Fund FWF:
  Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST
  Austria to D.S. and EMBL to S.D.R.'
article_processing_charge: No
article_type: original
author:
- first_name: Maria
  full_name: Akhmanova, Maria
  id: 3425EC26-F248-11E8-B48F-1D18A9856A87
  last_name: Akhmanova
  orcid: 0000-0003-1522-3162
- first_name: Shamsi
  full_name: Emtenani, Shamsi
  id: 49D32318-F248-11E8-B48F-1D18A9856A87
  last_name: Emtenani
  orcid: 0000-0001-6981-6938
- first_name: Daniel
  full_name: Krueger, Daniel
  last_name: Krueger
- first_name: Attila
  full_name: György, Attila
  id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
  last_name: György
  orcid: 0000-0002-1819-198X
- first_name: Mariana
  full_name: Pereira Guarda, Mariana
  id: 6de81d9d-e2f2-11eb-945a-af8bc2a60b26
  last_name: Pereira Guarda
  orcid: 0000-0001-8238-480X
- first_name: Mikhail
  full_name: Vlasov, Mikhail
  last_name: Vlasov
- first_name: Fedor
  full_name: Vlasov, Fedor
  last_name: Vlasov
- first_name: Andrei
  full_name: Akopian, Andrei
  last_name: Akopian
- first_name: Aparna
  full_name: Ratheesh, Aparna
  id: 2F064CFE-F248-11E8-B48F-1D18A9856A87
  last_name: Ratheesh
  orcid: 0000-0001-7190-0776
- first_name: Stefano
  full_name: De Renzis, Stefano
  last_name: De Renzis
- first_name: Daria E
  full_name: Siekhaus, Daria E
  id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
  last_name: Siekhaus
  orcid: 0000-0001-8323-8353
citation:
  ama: Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables
    macrophage infiltration. <i>Science</i>. 2022;376(6591):394-396. doi:<a href="https://doi.org/10.1126/science.abj0425">10.1126/science.abj0425</a>
  apa: Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov,
    M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration.
    <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.abj0425">https://doi.org/10.1126/science.abj0425</a>
  chicago: Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana
    Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues
    Enables Macrophage Infiltration.” <i>Science</i>. American Association for the
    Advancement of Science, 2022. <a href="https://doi.org/10.1126/science.abj0425">https://doi.org/10.1126/science.abj0425</a>.
  ieee: M. Akhmanova <i>et al.</i>, “Cell division in tissues enables macrophage infiltration,”
    <i>Science</i>, vol. 376, no. 6591. American Association for the Advancement of
    Science, pp. 394–396, 2022.
  ista: Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M,
    Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division
    in tissues enables macrophage infiltration. Science. 376(6591), 394–396.
  mla: Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.”
    <i>Science</i>, vol. 376, no. 6591, American Association for the Advancement of
    Science, 2022, pp. 394–96, doi:<a href="https://doi.org/10.1126/science.abj0425">10.1126/science.abj0425</a>.
  short: M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov,
    F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022)
    394–396.
corr_author: '1'
date_created: 2022-02-01T11:23:18Z
date_published: 2022-04-22T00:00:00Z
date_updated: 2025-04-15T07:25:41Z
day: '22'
department:
- _id: DaSi
doi: 10.1126/science.abj0425
external_id:
  isi:
  - '000788553700039'
  pmid:
  - '35446632'
intvolume: '       376'
isi: 1
issue: '6591'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2021.04.19.438995
month: '04'
oa: 1
oa_version: Preprint
page: 394-396
pmid: 1
project:
- _id: 264CBBAC-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02379
  name: Modeling epithelial tissue mechanics during cell invasion
publication: Science
publication_identifier:
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell division in tissues enables macrophage infiltration
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 376
year: '2022'
...