---
_id: '10714'
abstract:
- lang: eng
  text: Ribosomal defects perturb stem cell differentiation, causing diseases called
    ribosomopathies. How ribosome levels control stem cell differentiation is not
    fully known. Here, we discovered three RNA helicases are required for ribosome
    biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named
    Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest
    and stalled GSC differentiation. Unexpectedly, Aramis is required for efficient
    translation of a cohort of mRNAs containing a 5’-Terminal-Oligo-Pyrimidine (TOP)-motif,
    including mRNAs that encode ribosomal proteins and a conserved p53 inhibitor,
    Novel Nucleolar protein 1 (Non1). The TOP-motif co-regulates the translation of
    growth-related mRNAs in mammals. As in mammals, the La-related protein co-regulates
    the translation of TOP-motif containing RNAs during Drosophila oogenesis. Thus,
    a previously unappreciated TOP-motif in Drosophila responds to reduced ribosome
    biogenesis to co-regulate the translation of ribosomal proteins and a p53 repressor,
    thus coupling ribosome biogenesis to GSC differentiation.
acknowledgement: We are grateful to all members of the Rangan and Fuchs labs for their
  discussion and comments on the manuscript. We also thanks Dr. Sammons, Dr. Marlow,
  Life Science Editors, for their thoughts and comments the manuscript Additionally,
  we thank the Bloomington Stock Center, the Vienna Drosophila Resource Center, the
  BDGP Gene Disruption Project, and Flybase for fly stocks, reagents, and other resources.
  P.R. is funded by the NIH/NIGMS (R01GM111779-06 and RO1GM135628-01), G.F. is funded
  by NSF MCB-2047629 and NIH RO3 AI144839, D.E.S. was funded by Marie Curie CIG 334077/IRTIM
  and the Austrian Science Fund (FWF) grant ASI_FWF01_P29638S, and A.B is funded by
  NIH R01GM116889 and American Cancer Society RSG-17-197-01-RMC.
article_processing_charge: No
article_type: original
author:
- first_name: Elliot T.
  full_name: Martin, Elliot T.
  last_name: Martin
- first_name: Patrick
  full_name: Blatt, Patrick
  last_name: Blatt
- first_name: Elaine
  full_name: Ngyuen, Elaine
  last_name: Ngyuen
- first_name: Roni
  full_name: Lahr, Roni
  last_name: Lahr
- first_name: Sangeetha
  full_name: Selvam, Sangeetha
  last_name: Selvam
- first_name: Hyun Ah M.
  full_name: Yoon, Hyun Ah M.
  last_name: Yoon
- first_name: Tyler
  full_name: Pocchiari, Tyler
  last_name: Pocchiari
- first_name: Shamsi
  full_name: Emtenani, Shamsi
  id: 49D32318-F248-11E8-B48F-1D18A9856A87
  last_name: Emtenani
  orcid: 0000-0001-6981-6938
- first_name: Daria E
  full_name: Siekhaus, Daria E
  id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
  last_name: Siekhaus
  orcid: 0000-0001-8323-8353
- first_name: Andrea
  full_name: Berman, Andrea
  last_name: Berman
- first_name: Gabriele
  full_name: Fuchs, Gabriele
  last_name: Fuchs
- first_name: Prashanth
  full_name: Rangan, Prashanth
  last_name: Rangan
citation:
  ama: Martin ET, Blatt P, Ngyuen E, et al. A translation control module coordinates
    germline stem cell differentiation with ribosome biogenesis during Drosophila
    oogenesis. <i>Developmental Cell</i>. 2022;57(7):883-900.e10. doi:<a href="https://doi.org/10.1016/j.devcel.2022.03.005">10.1016/j.devcel.2022.03.005</a>
  apa: Martin, E. T., Blatt, P., Ngyuen, E., Lahr, R., Selvam, S., Yoon, H. A. M.,
    … Rangan, P. (2022). A translation control module coordinates germline stem cell
    differentiation with ribosome biogenesis during Drosophila oogenesis. <i>Developmental
    Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2022.03.005">https://doi.org/10.1016/j.devcel.2022.03.005</a>
  chicago: Martin, Elliot T., Patrick Blatt, Elaine Ngyuen, Roni Lahr, Sangeetha Selvam,
    Hyun Ah M. Yoon, Tyler Pocchiari, et al. “A Translation Control Module Coordinates
    Germline Stem Cell Differentiation with Ribosome Biogenesis during Drosophila
    Oogenesis.” <i>Developmental Cell</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.devcel.2022.03.005">https://doi.org/10.1016/j.devcel.2022.03.005</a>.
  ieee: E. T. Martin <i>et al.</i>, “A translation control module coordinates germline
    stem cell differentiation with ribosome biogenesis during Drosophila oogenesis,”
    <i>Developmental Cell</i>, vol. 57, no. 7. Elsevier, p. 883–900.e10, 2022.
  ista: Martin ET, Blatt P, Ngyuen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani
    S, Siekhaus DE, Berman A, Fuchs G, Rangan P. 2022. A translation control module
    coordinates germline stem cell differentiation with ribosome biogenesis during
    Drosophila oogenesis. Developmental Cell. 57(7), 883–900.e10.
  mla: Martin, Elliot T., et al. “A Translation Control Module Coordinates Germline
    Stem Cell Differentiation with Ribosome Biogenesis during Drosophila Oogenesis.”
    <i>Developmental Cell</i>, vol. 57, no. 7, Elsevier, 2022, p. 883–900.e10, doi:<a
    href="https://doi.org/10.1016/j.devcel.2022.03.005">10.1016/j.devcel.2022.03.005</a>.
  short: E.T. Martin, P. Blatt, E. Ngyuen, R. Lahr, S. Selvam, H.A.M. Yoon, T. Pocchiari,
    S. Emtenani, D.E. Siekhaus, A. Berman, G. Fuchs, P. Rangan, Developmental Cell
    57 (2022) 883–900.e10.
date_created: 2022-02-01T13:15:05Z
date_published: 2022-04-11T00:00:00Z
date_updated: 2025-06-12T06:19:50Z
day: '11'
department:
- _id: DaSi
doi: 10.1016/j.devcel.2022.03.005
ec_funded: 1
external_id:
  isi:
  - '000789021800005'
  pmid:
  - '35413237'
intvolume: '        57'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2021.04.04.438367
month: '04'
oa: 1
oa_version: Preprint
page: 883-900.e10
pmid: 1
project:
- _id: 2536F660-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '334077'
  name: Investigating the role of transporters in invasive migration through junctions
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29638
  name: The role of Drosophila TNF alpha in immune cell invasion
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A translation control module coordinates germline stem cell differentiation
  with ribosome biogenesis during Drosophila oogenesis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2022'
...