---
_id: '10719'
abstract:
- lang: eng
  text: Auxin, one of the first identified and most widely studied phytohormones,
    has been and will remain a hot topic in plant biology. After more than a century
    of passionate exploration, the mysteries of its synthesis, transport, signaling,
    and metabolism have largely been unlocked. Due to the rapid development of new
    technologies, new methods, and new genetic materials, the study of auxin has entered
    the fast lane over the past 30 years. Here, we highlight advances in understanding
    auxin signaling, including auxin perception, rapid auxin responses, TRANSPORT
    INHIBITOR RESPONSE 1 and AUXIN SIGNALING F-boxes (TIR1/AFBs)-mediated transcriptional
    and non-transcriptional branches, and the epigenetic regulation of auxin signaling.
    We also focus on feedback inhibition mechanisms that prevent the over-amplification
    of auxin signals. In addition, we cover the TRANSMEMBRANE KINASEs (TMKs)-mediated
    non-canonical signaling, which converges with TIR1/AFBs-mediated transcriptional
    regulation to coordinate plant growth and development. The identification of additional
    auxin signaling components and their regulation will continue to open new avenues
    of research in this field, leading to an increasingly deeper, more comprehensive
    understanding of how auxin signals are interpreted at the cellular level to regulate
    plant growth and development.
acknowledgement: "This research was financially supported by the National Natural
  Science Foundation of China and the Israel Science Foundation (NSFC-ISF; 32061143005),
  National Natural Science Foundation of China (32000225), Natural Science Foundation
  of Shandong Province (ZR2020QC036), and China Postdoctoral Science Foundation (2020M682165).\r\n"
article_processing_charge: No
article_type: review
author:
- first_name: Z
  full_name: Yu, Z
  last_name: Yu
- first_name: F
  full_name: Zhang, F
  last_name: Zhang
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Z
  full_name: Ding, Z
  last_name: Ding
citation:
  ama: 'Yu Z, Zhang F, Friml J, Ding Z. Auxin signaling: Research advances over the
    past 30 years. <i>Journal of Integrative Plant Biology</i>. 2022;64(2):371-392.
    doi:<a href="https://doi.org/10.1111/jipb.13225">10.1111/jipb.13225</a>'
  apa: 'Yu, Z., Zhang, F., Friml, J., &#38; Ding, Z. (2022). Auxin signaling: Research
    advances over the past 30 years. <i>Journal of Integrative Plant Biology</i>.
    Wiley. <a href="https://doi.org/10.1111/jipb.13225">https://doi.org/10.1111/jipb.13225</a>'
  chicago: 'Yu, Z, F Zhang, Jiří Friml, and Z Ding. “Auxin Signaling: Research Advances
    over the Past 30 Years.” <i>Journal of Integrative Plant Biology</i>. Wiley, 2022.
    <a href="https://doi.org/10.1111/jipb.13225">https://doi.org/10.1111/jipb.13225</a>.'
  ieee: 'Z. Yu, F. Zhang, J. Friml, and Z. Ding, “Auxin signaling: Research advances
    over the past 30 years,” <i>Journal of Integrative Plant Biology</i>, vol. 64,
    no. 2. Wiley, pp. 371–392, 2022.'
  ista: 'Yu Z, Zhang F, Friml J, Ding Z. 2022. Auxin signaling: Research advances
    over the past 30 years. Journal of Integrative Plant Biology. 64(2), 371–392.'
  mla: 'Yu, Z., et al. “Auxin Signaling: Research Advances over the Past 30 Years.”
    <i>Journal of Integrative Plant Biology</i>, vol. 64, no. 2, Wiley, 2022, pp.
    371–92, doi:<a href="https://doi.org/10.1111/jipb.13225">10.1111/jipb.13225</a>.'
  short: Z. Yu, F. Zhang, J. Friml, Z. Ding, Journal of Integrative Plant Biology
    64 (2022) 371–392.
corr_author: '1'
date_created: 2022-02-03T09:52:59Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2026-06-18T08:47:21Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/jipb.13225
external_id:
  isi:
  - '000761281200011'
  pmid:
  - '35018726'
intvolume: '        64'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/jipb.13225
month: '02'
oa: 1
oa_version: Published Version
page: 371-392
pmid: 1
publication: Journal of Integrative Plant Biology
publication_identifier:
  eissn:
  - 1744-7909
  issn:
  - 1672-9072
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Auxin signaling: Research advances over the past 30 years'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 64
year: '2022'
...