---
_id: '1074'
abstract:
- lang: eng
  text: Recently it has become feasible to detect long blocks of nearly identical
    sequence shared between pairs of genomes. These IBD blocks are direct traces of
    recent coalescence events and, as such, contain ample signal to infer recent demography.
    Here, we examine sharing of such blocks in two-dimensional populations with local
    migration. Using a diffusion approximation to trace genetic ancestry, we derive
    analytical formulae for patterns of isolation by distance of IBD blocks, which
    can also incorporate recent population density changes. We introduce an inference
    scheme that uses a composite likelihood approach to fit these formulae. We then
    extensively evaluate our theory and inference method on a range of scenarios using
    simulated data. We first validate the diffusion approximation by showing that
    the theoretical results closely match the simulated block sharing patterns. We
    then demonstrate that our inference scheme can accurately and robustly infer dispersal
    rate and effective density, as well as bounds on recent dynamics of population
    density. To demonstrate an application, we use our estimation scheme to explore
    the fit of a diffusion model to Eastern European samples in the POPRES data set.
    We show that ancestry diffusing with a rate of σ ≈ 50–100 km/√gen during the last
    centuries, combined with accelerating population growth, can explain the observed
    exponential decay of block sharing with increasing pairwise sample distance.
article_processing_charge: No
author:
- first_name: Harald
  full_name: Ringbauer, Harald
  id: 417FCFF4-F248-11E8-B48F-1D18A9856A87
  last_name: Ringbauer
  orcid: 0000-0002-4884-9682
- first_name: Graham
  full_name: Coop, Graham
  last_name: Coop
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Ringbauer H, Coop G, Barton NH. Inferring recent demography from isolation
    by distance of long shared sequence blocks. <i>Genetics</i>. 2017;205(3):1335-1351.
    doi:<a href="https://doi.org/10.1534/genetics.116.196220">10.1534/genetics.116.196220</a>
  apa: Ringbauer, H., Coop, G., &#38; Barton, N. H. (2017). Inferring recent demography
    from isolation by distance of long shared sequence blocks. <i>Genetics</i>. Genetics
    Society of America. <a href="https://doi.org/10.1534/genetics.116.196220">https://doi.org/10.1534/genetics.116.196220</a>
  chicago: Ringbauer, Harald, Graham Coop, and Nicholas H Barton. “Inferring Recent
    Demography from Isolation by Distance of Long Shared Sequence Blocks.” <i>Genetics</i>.
    Genetics Society of America, 2017. <a href="https://doi.org/10.1534/genetics.116.196220">https://doi.org/10.1534/genetics.116.196220</a>.
  ieee: H. Ringbauer, G. Coop, and N. H. Barton, “Inferring recent demography from
    isolation by distance of long shared sequence blocks,” <i>Genetics</i>, vol. 205,
    no. 3. Genetics Society of America, pp. 1335–1351, 2017.
  ista: Ringbauer H, Coop G, Barton NH. 2017. Inferring recent demography from isolation
    by distance of long shared sequence blocks. Genetics. 205(3), 1335–1351.
  mla: Ringbauer, Harald, et al. “Inferring Recent Demography from Isolation by Distance
    of Long Shared Sequence Blocks.” <i>Genetics</i>, vol. 205, no. 3, Genetics Society
    of America, 2017, pp. 1335–51, doi:<a href="https://doi.org/10.1534/genetics.116.196220">10.1534/genetics.116.196220</a>.
  short: H. Ringbauer, G. Coop, N.H. Barton, Genetics 205 (2017) 1335–1351.
date_created: 2018-12-11T11:50:00Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2026-04-08T14:06:35Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.116.196220
ec_funded: 1
external_id:
  isi:
  - '000395807200023'
fulldoi: https://doi.org/10.1534/genetics.116.196220
intvolume: '       205'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.biorxiv.org/content/early/2016/09/23/076810
month: '03'
oa: 1
oa_version: Preprint
page: 1335 - 1351
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '6307'
quality_controlled: '1'
related_material:
  record:
  - id: '200'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Inferring recent demography from isolation by distance of long shared sequence
  blocks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 205
year: '2017'
...