---
res:
  bibo_abstract:
  - "AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory\r\nsynapses
    in the brain. Glutamate binding to the receptor’s ligand-binding domains (LBDs)\r\nleads
    to ion channel activation and desensitization. Gating kinetics shape synaptic
    transmission\r\nand are strongly modulated by transmembrane AMPAR regulatory proteins
    (TARPs)\r\nthrough currently incompletely resolved mechanisms. Here, electron
    cryo-microscopy\r\nstructures of the GluA1/2 TARP-γ8 complex, in both open and
    desensitized states\r\n(at 3.5 Å), reveal state-selective engagement of the LBDs
    by the large TARP-γ8 loop (‘β1’),\r\nelucidating how this TARP stabilizes specific
    gating states. We further show how TARPs alter\r\nchannel rectification, by interacting
    with the pore helix of the selectivity filter. Lastly, we\r\nreveal that the Q/R-editing
    site couples the channel constriction at the filter entrance to the\r\ngate, and
    forms the major cation binding site in the conduction path. Our results provide
    a\r\nmechanistic framework of how TARPs modulate AMPAR gating and conductance.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Beatriz
      foaf_name: Herguedas, Beatriz
      foaf_surname: Herguedas
  - foaf_Person:
      foaf_givenName: Bianka K.
      foaf_name: Kohegyi, Bianka K.
      foaf_surname: Kohegyi
  - foaf_Person:
      foaf_givenName: Jan Niklas
      foaf_name: Dohrke, Jan Niklas
      foaf_surname: Dohrke
  - foaf_Person:
      foaf_givenName: Jake
      foaf_name: Watson, Jake
      foaf_surname: Watson
      foaf_workInfoHomepage: http://www.librecat.org/personId=63836096-4690-11EA-BD4E-32803DDC885E
    orcid: 0000-0002-8698-3823
  - foaf_Person:
      foaf_givenName: Danyang
      foaf_name: Zhang, Danyang
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Hinze
      foaf_name: Ho, Hinze
      foaf_surname: Ho
  - foaf_Person:
      foaf_givenName: Saher A.
      foaf_name: Shaikh, Saher A.
      foaf_surname: Shaikh
  - foaf_Person:
      foaf_givenName: Remigijus
      foaf_name: Lape, Remigijus
      foaf_surname: Lape
  - foaf_Person:
      foaf_givenName: James M.
      foaf_name: Krieger, James M.
      foaf_surname: Krieger
  - foaf_Person:
      foaf_givenName: Ingo H.
      foaf_name: Greger, Ingo H.
      foaf_surname: Greger
  bibo_doi: 10.1038/s41467-022-28404-7
  bibo_volume: 13
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000757297200008
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor@
  fabio_hasPubmedId: '35136046'
...