--- res: bibo_abstract: - The t-haplotype of mice is a classical model for autosomal transmission distortion. A largely non-recombining variant of the proximal region of chromosome 17, it is transmitted to more than 90% of the progeny of heterozygous males through the disabling of sperm carrying a standard chromosome. While extensive genetic and functional work has shed light on individual genes involved in drive, much less is known about the evolution and function of the rest of its hundreds of genes. Here, we characterize the sequence and expression of dozens of t-specific transcripts and of their chromosome 17 homologues. Many genes showed reduced expression of the t-allele, but an equal number of genes showed increased expression of their t-copy, consistent with increased activity or a newly evolved function. Genes on the t-haplotype had a significantly higher non-synonymous substitution rate than their homologues on the standard chromosome, with several genes harbouring dN/dS ratios above 1. Finally, the t-haplotype has acquired at least two genes from other chromosomes, which show high and tissue-specific expression. These results provide a first overview of the gene content of this selfish element, and support a more dynamic evolutionary scenario than expected of a large genomic region with almost no recombination.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Réka K foaf_name: Kelemen, Réka K foaf_surname: Kelemen foaf_workInfoHomepage: http://www.librecat.org/personId=48D3F8DE-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Marwan N foaf_name: Elkrewi, Marwan N foaf_surname: Elkrewi foaf_workInfoHomepage: http://www.librecat.org/personId=0B46FACA-A8E1-11E9-9BD3-79D1E5697425 orcid: 0000-0002-5328-7231 - foaf_Person: foaf_givenName: Anna K. foaf_name: Lindholm, Anna K. foaf_surname: Lindholm - foaf_Person: foaf_givenName: Beatriz foaf_name: Vicoso, Beatriz foaf_surname: Vicoso foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4579-8306 bibo_doi: 10.1098/rspb.2021.1985 bibo_issue: '1968' bibo_volume: 289 dct_date: 2022^xs_gYear dct_identifier: - UT:000752812800012 dct_isPartOf: - http://id.crossref.org/issn/14712954 dct_language: eng dct_publisher: The Royal Society@ dct_title: Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome@ fabio_hasPubmedId: '35135349' ...