---
res:
  bibo_abstract:
  - Microglia cells are active players in regulating synaptic development and plasticity
    in the brain. However, how they influence the normal functioning of synapses is
    largely unknown. In this study, we characterized the effects of pharmacological
    microglia depletion, achieved by administration of PLX5622, on hippocampal CA3-CA1
    synapses of adult wild type mice. Following microglial depletion, we observed
    a reduction of spontaneous and evoked glutamatergic activity associated with a
    decrease of dendritic spine density. We also observed the appearance of immature
    synaptic features and higher levels of plasticity. Microglia depleted mice showed
    a deficit in the acquisition of the Novel Object Recognition task. These events
    were accompanied by hippocampal astrogliosis, although in the absence ofneuroinflammatory
    condition. PLX-induced synaptic changes were absent in Cx3cr1−/− mice, highlighting
    the role of CX3CL1/CX3CR1 axis in microglia control of synaptic functioning. Remarkably,
    microglia repopulation after PLX5622 withdrawal was associated with the recovery
    of hippocampal synapses and learning functions. Altogether, these data demonstrate
    that microglia contribute to normal synaptic functioning in the adult brain and
    that their removal induces reversible changes in organization and activity of
    glutamatergic synapses.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Bernadette
      foaf_name: Basilico, Bernadette
      foaf_surname: Basilico
      foaf_workInfoHomepage: http://www.librecat.org/personId=36035796-5ACA-11E9-A75E-7AF2E5697425
    orcid: 0000-0003-1843-3173
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Ferrucci, Laura
      foaf_surname: Ferrucci
  - foaf_Person:
      foaf_givenName: Patrizia
      foaf_name: Ratano, Patrizia
      foaf_surname: Ratano
  - foaf_Person:
      foaf_givenName: Maria T.
      foaf_name: Golia, Maria T.
      foaf_surname: Golia
  - foaf_Person:
      foaf_givenName: Alfonso
      foaf_name: Grimaldi, Alfonso
      foaf_surname: Grimaldi
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Rosito, Maria
      foaf_surname: Rosito
  - foaf_Person:
      foaf_givenName: Valentina
      foaf_name: Ferretti, Valentina
      foaf_surname: Ferretti
  - foaf_Person:
      foaf_givenName: Ingrid
      foaf_name: Reverte, Ingrid
      foaf_surname: Reverte
  - foaf_Person:
      foaf_givenName: Caterina
      foaf_name: Sanchini, Caterina
      foaf_surname: Sanchini
  - foaf_Person:
      foaf_givenName: Maria C.
      foaf_name: Marrone, Maria C.
      foaf_surname: Marrone
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Giubettini, Maria
      foaf_surname: Giubettini
  - foaf_Person:
      foaf_givenName: Valeria
      foaf_name: De Turris, Valeria
      foaf_surname: De Turris
  - foaf_Person:
      foaf_givenName: Debora
      foaf_name: Salerno, Debora
      foaf_surname: Salerno
  - foaf_Person:
      foaf_givenName: Stefano
      foaf_name: Garofalo, Stefano
      foaf_surname: Garofalo
  - foaf_Person:
      foaf_givenName: Marie‐Kim
      foaf_name: St‐Pierre, Marie‐Kim
      foaf_surname: St‐Pierre
  - foaf_Person:
      foaf_givenName: Micael
      foaf_name: Carrier, Micael
      foaf_surname: Carrier
  - foaf_Person:
      foaf_givenName: Massimiliano
      foaf_name: Renzi, Massimiliano
      foaf_surname: Renzi
  - foaf_Person:
      foaf_givenName: Francesca
      foaf_name: Pagani, Francesca
      foaf_surname: Pagani
  - foaf_Person:
      foaf_givenName: Brijesh
      foaf_name: Modi, Brijesh
      foaf_surname: Modi
  - foaf_Person:
      foaf_givenName: Marcello
      foaf_name: Raspa, Marcello
      foaf_surname: Raspa
  - foaf_Person:
      foaf_givenName: Ferdinando
      foaf_name: Scavizzi, Ferdinando
      foaf_surname: Scavizzi
  - foaf_Person:
      foaf_givenName: Cornelius T.
      foaf_name: Gross, Cornelius T.
      foaf_surname: Gross
  - foaf_Person:
      foaf_givenName: Silvia
      foaf_name: Marinelli, Silvia
      foaf_surname: Marinelli
  - foaf_Person:
      foaf_givenName: Marie‐Ève
      foaf_name: Tremblay, Marie‐Ève
      foaf_surname: Tremblay
  - foaf_Person:
      foaf_givenName: Daniele
      foaf_name: Caprioli, Daniele
      foaf_surname: Caprioli
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Maggi, Laura
      foaf_surname: Maggi
  - foaf_Person:
      foaf_givenName: Cristina
      foaf_name: Limatola, Cristina
      foaf_surname: Limatola
  - foaf_Person:
      foaf_givenName: Silvia
      foaf_name: Di Angelantonio, Silvia
      foaf_surname: Di Angelantonio
  - foaf_Person:
      foaf_givenName: Davide
      foaf_name: Ragozzino, Davide
      foaf_surname: Ragozzino
  bibo_doi: 10.1002/glia.24101
  bibo_issue: '1'
  bibo_volume: 70
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000708025800001
  dct_isPartOf:
  - http://id.crossref.org/issn/0894-1491
  - http://id.crossref.org/issn/1098-1136
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Cellular and Molecular Neuroscience
  - Neurology
  dct_title: Microglia control glutamatergic synapses in the adult mouse hippocampus@
  fabio_hasPubmedId: '34661306'
...